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Saraschandra Vallabhajosyula, Arun Kanmanthareddy, Patricia J Erwin, Dennis J Esterbrooks, Lee E Morrow
BACKGROUND: The data evaluating the role of statins in delirium prevention in the intensive care unit are conflicting and limited. METHODS: We performed a systematic review and meta-analysis of literature from 1975 to 2015. All English-language adult studies evaluating delirium incidence in statin and statin nonusers were included and studies without a control group were excluded. Mantel-Haenszel model was used to calculate pooled risk ratios (RRs) and 95% confidence intervals (CIs)...
October 8, 2016: Journal of Critical Care
Florian Matt, Tom Cole-Hunter, David Donaire-Gonzalez, Nadine Kubesch, David Martínez, Glòria Carrasco-Turigas, Mark Nieuwenhuijsen
BACKGROUND: Physical activity (PA) has beneficial, whereas exposure to traffic related air pollution (TRAP) has adverse, respiratory effects. Few studies, however, have examined if the acute effects of TRAP upon respiratory outcomes are modified depending on the level of PA. OBJECTIVES: The aim of our study was to disentangle acute effects of TRAP and PA upon respiratory outcomes and assess the impact of participants TRAP pre-exposure. METHODS: We conducted a real-world crossover study with repeated measures of 30 healthy adults...
October 20, 2016: Environment International
Mohammadhossein Hajiebrahimi, Scott Montgomery, Sarah Burkill, Shahram Bahmanyar
OBJECTIVE: To investigate risk of premenopausal and postmenopausal breast cancer among Multiple Sclerosis (MS) patients, considering tumor stage. METHODS: The Swedish Patient Register identified 19,330 women with MS between 1968 and 2012, matched individually with a cohort of 193,458 without MS. Matching variables were year of birth, sex, region of residence and vital status at the time of diagnosis. The cancer register identified 471 and 5,753 breast cancer cases among the MS and non-MS cohorts, respectively...
2016: PloS One
Robert Froud, Shilpa Patel, Dévan Rajendran, Philip Bright, Tom Bjørkli, Rachelle Buchbinder, Sandra Eldridge, Martin Underwood
BACKGROUND: Increasing patient-reported outcome measures in the 1980s and 1990s led to the development of recommendations at the turn of the millennium for standardising outcome measures in non-specific low back pain (LBP) trials. Whether these recommendations impacted use is unclear. Previous work has examined citation counts, but actual use and change over time, has not been explored. Since 2011, there has been some consensus on the optimal methods for reporting back pain trial outcomes...
2016: PloS One
Lise Løvereide, Peter Hagell
The 5-item Satisfaction With Life Scale (SWLS) was designed to measure general life satisfaction (LS). Here we examined the psychometric properties of the SWLS in a cohort of persons with Parkinson`s disease (PwPD) and age and gender matched individuals without PD. The SWLS was administered to PwPD and controls from the Norwegian ParkWest study at 5 and 7 years after the time of diagnosis. Data were analysed according to classical test theory (CTT) and Rasch measurement theory. CTT scaling assumptions for computation of a SWLS total score were met (corrected item-total correlations >0...
2016: PloS One
Yiqian Cui, Junyou Shi, Zili Wang
The centers and radii of radial basis functions (RBFs) greatly affect the approximation capability of RBF networks (RBFNs). Traditional statistics-based approaches are widely used, but they may lack adaptivity to different data structures. Quantum clustering (QC), derived from quantum mechanics and the Schrödinger equation, demonstrates excellent capability in finding the structure and conformity toward data distribution. In this paper, a novel neural networks model called quantum local potential function networks (QLPFNs) is proposed...
October 20, 2016: IEEE Transactions on Neural Networks and Learning Systems
Y-F Wang, S Zhang, X-Q Li, Y Wang
OBJECTIVE: To investigate Long non-coding RNA HULC (HULC) expression in cervical cancer and to evaluate its clinical significance. PATIENTS AND METHODS: HULC expression in 244 pairs of human cervical cancer and adjacent normal tissues was detected by real-time quantitative RT-PCR assay. The correlation between HULC and clinicopathological factors was also evaluated. The clinical and prognostic significance of HULC expression was analyzed statistically by Kaplan-Meier estimate and Cox regression model...
October 2016: European Review for Medical and Pharmacological Sciences
Ricardo Dias de Castro, Marianne de Lucena Rangel, Marcos André Azevedo da Silva, Brunna Thaís Lucwu de Lucena, Alessandro Leite Cavalcanti, Paulo Rogério Ferreti Bonan, Julyana de Araújo Oliveira
The Specialized Dental Clinics (SDCs) represent the first government initiative in Latin America aimed at providing specialized oral health services. This study sought to evaluate the organizational accessibility to specialized oral health care services in Brazil and to understand the factors that may be associated with accessibility from the user's perspective. This epidemiological, cross-sectional and quantitative study was conducted by means of interviews with individuals who sought specialized public oral health services in the city of João Pessoa, Paraíba, Brazil, and consisted of a sample of 590 individuals...
October 19, 2016: International Journal of Environmental Research and Public Health
Ali Fatih Demir, Qammer Abbasi, Zekeriyya Esat Ankarali, Akram Alomainy, Khalid Qaraqe, Erchin Serpedin, Huseyin Arslan
In vivo wireless body area networks (WBANs) and their associated technologies are shaping the future of healthcare by providing continuous health monitoring and noninvasive surgical capabilities, in addition to remote diagnostic and treatment of diseases. To fully exploit the potential of such devices, it is necessary to characterize the communication channel which will help to build reliable and high-performance communication systems. This paper presents an in vivo wireless communication channel characterization for male torso both numerically and experimentally (on a human cadaver) considering various organs at 915 MHz and 2...
October 19, 2016: IEEE Journal of Biomedical and Health Informatics
Jian Zhang, Haiting Chai, Bo Gao, Guifu Yang, Zhiqiang Ma
Heme is an essential biomolecule that widely exists in numerous extant organisms. Accurately identifying heme binding residues (HEMEs) is of great importance in disease progression and drug development. In this study, a novel predictor named HEMEsPred was proposed for predicting HEMEs. First, several sequence- and structure-based features, including amino acid composition, motifs, surface preferences and secondary structure, were collected to construct feature matrices. Second, a novel fast-adaptive ensemble learning scheme was designed to overcome the serious class-imbalance problem as well as to enhance the prediction performance...
October 4, 2016: IEEE/ACM Transactions on Computational Biology and Bioinformatics
Jessica M Andriolo, Richard J Rossi, Casey A McConnell, Baili I Connors, Kevin Trout, M K Hailer, Marisa L Pedulla, Jack L Skinner
The Centers for Disease Control and Prevention have estimated that each year, two million people in the United States become infected with antibiotic-resistant bacteria, of which, approximately 23 000 die as a direct result of these infections. Phage therapy, or the treatment of bacterial infection by specific, antagonistic viruses, provides one alternative to traditional antibiotics. Bacteriophages, or phages, are bacteriaspecific viruses that possess biological traits that allow for not only the removal of bacterial infection, but also the evasion of bacterial resistance which renders antibiotics ineffective...
October 19, 2016: IEEE Transactions on Nanobioscience
Joseph Lucisano, Timothy Routh, Joe Lin, David Gough
OBJECTIVE: The use of a fully implanted, first-generation prototype sensor/telemetry system is described for long-term monitoring of subcutaneous tissue glucose in a small cohort of people with diabetes. METHODS: Sensors are based on a membrane containing immobilized glucose oxidase and catalase coupled to electrochemical oxygen detection and telemetry systems, integrated as an implant. The devices remained implanted for up to 180 days, with signals transmitted every 2 minutes to external receivers...
October 19, 2016: IEEE Transactions on Bio-medical Engineering
César González-Ramírez, Jesús Montanero-Fernández, Diego Peral-Pacheco
BACKGROUND: The extreme variability of Temporary disability duration causes a deep impact in Public Health. We try to understand what factors does duration of disability depend on. METHODS: Through cohort study with data of temporal disabilities collected by Ibermutuamur from 2008 to 2012, we use statistical multivariate methods. RESULTS: The most reliable and convenient algorithm to predict duration was a categorical classification tree that distinguished between brief and long disabilities, taking into account both medical-biological and socioeconomic factors...
October 24, 2016: Archives of Environmental & Occupational Health
Meghan K Edwards, Paul D Loprinzi
OBJECTIVE: Examine the independent association of sedentary behavior and cognitive function in older adults, as well as whether or not physical activity attenuates this potential association. METHODS: Data from the 1999-2002 National Health and Nutrition Examination Survey were used (N=2,472 adults 60-85 yrs). Sedentary behavior was subjectively assessed and the Digit Symbol Substitution Test (DSST) was employed to assess cognitive function. RESULTS: Among an unadjusted and an adjusted model not accounting for physical activity, only 5+ hrs/day (vs...
October 24, 2016: Journal of Physical Activity & Health
Alexander Rozental, Kristoffer Magnusson, Johanna Boettcher, Gerhard Andersson, Per Carlbring
Objective: Psychological treatments can relieve mental distress and improve well-being, and the dissemination of evidence-based methods can help patients gain access to the right type of aid. Meanwhile, Internet-based cognitive-behavioral therapy (ICBT) has shown promising results for many psychiatric disorders. However, research on the potential for negative effects of psychological treatments has been lacking. Method: An individual patient data meta-analysis of 29 clinical trials of ICBT (N = 2,866) was performed using the Reliable Change Index for each primary outcome measures to distinguish deterioration rates among patients in treatment and control conditions...
October 24, 2016: Journal of Consulting and Clinical Psychology
Gregory P Beehler, Kaitlin R Lilienthal
The Primary Care Behavioral Health (PCBH) model of integrated primary care is challenging to implement with high fidelity. The Primary Care Behavioral Health Provider Adherence Questionnaire (PPAQ) was designed to assess provider adherence to essential model components and has recently been adapted into a quality improvement toolkit. The aim of this pilot project was to gather preliminary feedback on providers' perceptions of the acceptability and utility of the PPAQ toolkit for making beneficial practice changes...
October 24, 2016: Psychological Services
H T Banks, John E Banks, R A Everett, John D Stark
We develop statistical and mathematical based methodologies for determining (as the experiment progresses) the amount of information required to complete the estimation of stable population parameters with pre-specified levels of confidence. We do this in the context of life table models and data for growth/death for three species of Daphniids as investigated by J. Stark and J. Banks [17]. The ideas developed here also have wide application in the health and social sciences where experimental data are often expensive as well as difficult to obtain...
August 1, 2016: Mathematical Biosciences and Engineering: MBE
Dohee Lim, Won Kyung Lee, Hyesook Park
The purpose of this study was to estimate the national burden of mental substance disorders on medical care utilization in Korea using National Health Insurance System (NHIS) data and updated disability weight, in terms of disability-adjusted life years (DALYs). For each of the 24 disorders, the incident years lived with disability (YLDs) was calculated, using NHIS data to estimate prevalence and incidence rates. The DisMod-II software program was used to model duration and remission. The years of life lost (YLLs) due to premature death were calculated from causes of death statistics...
November 2016: Journal of Korean Medical Science
Maureen Le Danseur, Sonja E Stutzman, Jennifer Wilson, Isabelle Sislak, DaiWai M Olson
PURPOSE: This study examined the effectiveness of the consensus model (Clinical Advisory Board for Intermittent Catheterization [CABIC] method) for teaching clean intermittent self-catheterization (ISC). The primary hypothesis was that the CABIC method of teaching ISC would result in higher ISC knowledge and performance scores. DESIGN: Prospective, non-randomized, pre-post study of an educational intervention of ISC education with nursing students. METHODS: Nursing students completed a self-report pre/posttest, education of the CABIC method, and video recording of the CABIC method using same-gendered manikins...
October 24, 2016: Rehabilitation Nursing: the Official Journal of the Association of Rehabilitation Nurses
Abra Jeffers, Vanessa Sochat, Michael W Kattan, Changhong Yu, Erin Melcon, Kosi Yamoah, Timothy R Rebbeck, Alice S Whittemore
BACKGROUND: Prostate cancer prognosis is variable, and management decisions involve balancing patients' risks of recurrence and recurrence-free death. Moreover, the roles of body mass index (BMI) and race in risk of recurrence are controversial [1,2]. To address these issues, we developed and cross-validated RAPS (Risks After Prostate Surgery), a personal prediction model for biochemical recurrence (BCR) within 10 years of radical prostatectomy (RP) that includes BMI and race as possible predictors, and recurrence-free death as a competing risk...
October 24, 2016: Prostate
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