Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#1
JOURNAL ARTICLE
Lin Lin, Peilin Huang, Yingzhe Cheng, Shaofan Jiang, Jiejun Zhang, Man Li, Jiahao Zheng, Xiaodong Pan, Yanping Wang
BACKGROUND: The specific non-motor symptoms associated with α-synucleinopathies, including orthostatic hypotension (OH), cognitive impairment, and emotional abnormalities, have been a subject of ongoing controversy over the mechanisms underlying the development of a vicious cycle among them. The distinct structural alterations in white matter (WM) in patients with α-synucleinopathies experiencing OH, alongside their association with other non-motor symptoms, remain unexplored...
April 2024: CNS Neuroscience & Therapeutics
#2
JOURNAL ARTICLE
Adaptive promising zone design for cancer immunotherapy with heterogeneous delayed treatment effect.
Bosheng Li, Fangrong Yan, Depeng Jiang
Indirect mechanisms of cancer immunotherapies result in delayed treatment effects that vary among patients. Consequently, the use of the log-rank test in trial design and analysis can lead to significant power loss and pose additional challenges for interim decisions in adaptive designs. In this paper, we describe patients' survival using a piecewise proportional hazard model with random lag time and propose an adaptive promising zone design for cancer immunotherapy with heterogeneous delayed effects. We provide solutions for calculating conditional power and adjusting the critical value for the log-rank test with interim data...
April 14, 2024: Journal of Biopharmaceutical Statistics
#3
JOURNAL ARTICLE
F Camacho-Alonso, M Pérez-Sayáns, J Pato-Mourelo, J-E Martínez-Martínez
BACKGROUND: This study aimed to evaluate the surgical accuracy of a new universal disposable stop system for implant drills (FCA Universal Drill Stop). MATERIAL AND METHODS: A total of 60 bovine ribs were included in this in vitro study. The ribs were randomized into three study groups (n=20 ribs per group). In each study group (Group1: drills without stop or control group, Group 2: prefabricated drills with stop or gold standard group, and Group 3: drills with FCA Universal Drill Stop) a total of 100 osteotomies were performed with implant drills in each group, following the drilling sequence for the placement of a dental implant of 10 mm length and 4 mm diameter...
April 14, 2024: Medicina Oral, Patología Oral y Cirugía Bucal
#4
JOURNAL ARTICLE
Abera Gezume, Ermias Wabeto, Helen Alemayehu
BACKGROUND: The occurrence of pregnancy in the postpartum period poses a risk to women and their infants, and it also has increased risks of adverse health outcomes if a pregnancy happens less than two years after the preceding birth. Utilization of immediate postpartum family planning is a possible and simple way to reduce these unfavourable outcomes. However, only a small proportion of mothers use the service; but the reasons appear unclear. Thus, this study aimed to determine the level and factors associated with the utilization of immediate postpartum family planning in Bole sub-city, Addis Ababa, Ethiopia...
April 13, 2024: BMC Women's Health
#5
JOURNAL ARTICLE
Qing Duan, Yao Wang, Xiaolin Jiang, Shujun Ding, Yuwei Zhang, Mingxiao Yao, Bo Pang, Xueying Tian, Wei Ma, Zengqiang Kou, Hongling Wen
BACKGROUND: Hemorrhagic fever with renal syndrome (HFRS) signals a recurring risk in Eurasia in recent years owing to its continued rise in case notifications and the extension of geographical distribution. This study was undertaken to investigate the spatiotemporal drivers and incidence heterogeneity of HFRS transmission in Shandong Province. METHODS: The epidemiological data for HFRS, meteorological data and socioeconomic data were obtained from China Information System for Disease Control and Prevention, China Meteorological Data Sharing Service System, and Shandong Statistical Yearbook, respectively...
April 13, 2024: BMC Public Health
#6
JOURNAL ARTICLE
Han Shi, Kais Hyasat, Tejas Deshmukh, Cuneyt Ada, Joseph Chiha, Kaleab Asrress, Kevin Liou
BACKGROUND: The optimal management strategy for significant unprotected ostial left anterior descending artery (LAD) disease remains undefined. Merits of the two most common percutaneous approaches are considered in this quantitative synthesis. METHOD: A meta-analysis was performed to compare ostial stenting (OS) and crossover stenting (CS) in the treatment of unprotected ostial LAD stenosis. The primary outcome is the disparity in target lesion revascularisation (TLR)...
April 12, 2024: Heart, Lung & Circulation
#7
JOURNAL ARTICLE
Soyeon Kim, Chang-Ha Lee, Sunyoung Ma, Young-Seok Park
AIM: This study aimed to identify the optimal toothpaste for removing coffee-induced stains while also evaluating its impact on tooth enamel through roughness and abraded depth parameters, providing a comprehensive understanding of their effects. MATERIALS AND METHODS: Three whitening toothpastes and 2 conventional toothpastes were prepared for a simulated brushing procedure on coffee-stained bovine enamel tooth specimens. Using a toothbrushing machine, up to 10,000 brushstrokes were completed, while spectrophotometric readings were taken at designated intervals...
April 13, 2024: International Dental Journal
#8
JOURNAL ARTICLE
Asanthi M Ratnasekera, Sirivan S Seng, Daniel Kim, Wenyan Ji, Christina L Jacovides, Elinore J Kaufman, Hannah M Sadek, Lindsey L Perea, Christina Monaco Poloni, Ilya Shnaydman, Alexandra Jeongyoon Lee, Victoria Sharp, Angela Miciura, Eric Trevizo, Martin G Rosenthal, Lawrence Lottenberg, William Zhao, Alicia Keininger, Michele Hunt, John Cull, Chassidy Balentine, Tanya Egodage, Aleem T Mohamed, Michelle Kincaid, Stephanie Doris, Robert Cotterman, Sara Seegert, Lewis E Jacobson, Jamie Williams, Melissa Moncrief, Brandi Palmer, Caleb Mentzer, Nichole Tackett, Tjasa Hranjec, Thomas Dougherty, Shawna Morrissey, Lauren Donatelli-Seyler, Amy Rushing, Leah C Tatebe, Tiffany J Nevill, Michel B Aboutanos, David Hamilton, Diane Redmond, Daniel C Cullinane, Carolyne Falank, Mark McMellen, Chris Duran, Jennifer Daniels, Shana Ballow, Kevin M Schuster, Paula Ferrada
BACKGROUND: In patients with severe traumatic brain injury (TBI), clinicians must balance preventing venous thromboembolism (VTE) with the risk of intracranial hemorrhagic expansion (ICHE). We hypothesized that low molecular weight heparin (LMWH) would not increase risk of ICHE or VTE as compared to unfractionated heparin (UH) in patients with severe TBI. METHODS: Patients ≥ 18 years of age with isolated severe TBI (AIS ≥ 3), admitted to 24 level I and II trauma centers between January 1, 2014 to December 31, 2020 and who received subcutaneous UH and LMWH injections for chemical venous thromboembolism prophylaxis (VTEP) were included...
April 9, 2024: Injury
#9
REVIEW
Xinpeng Dai, Bingxin Zhao, Jiangnan Zang, Xinying Wang, Zongjie Liu, Tao Sun, Hong Yu, Xin Sui
RATIONALE AND OBJECTIVES: To systematically evaluate the application value of radiomics and deep learning (DL) in the differential diagnosis of benign and malignant soft tissue tumors (STTs). MATERIALS AND METHODS: A systematic review was conducted on studies published up to December 11, 2023, that utilized radiomics and DL methods for the diagnosis of STTs. The methodological quality and risk of bias were evaluated using the Radiomics Quality Score (RQS) 2.0 system and Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2) tool, respectively...
April 13, 2024: Academic Radiology
#10
JOURNAL ARTICLE
F Fernández-Valverde, M P Bautista-Bárcena, E Roldán-Romero, J Solivera-Vela, F Bravo-Rodríguez, M J Ramos-Gómez
OBJECTIVES: To evaluate if the tumour perfusion at the initial MRI scan is a marker of prognosis for survival in patients diagnosed with High Grade Gliomas (HGG). To analyse the risk factors which influence on the mortality from HGG to quantify the overall survival to be expected in patients. PATIENTS AND METHODS: The patients diagnosed with HGG through a MRI scan in a third-level hospital between 2017 and 2019 were selected. Clinical and tumour variables were collected...
2024: Radiología
#11
JOURNAL ARTICLE
Xianlin Zhu, Ya Yue, Lin Li, Liying Zhu, Yuexi Cai, Yanping Shu
BACKGROUND: Relative fat mass (RFM) is a novel indicator for measuring body fat. The relationship between RFM and depression was explored using National Health and Nutrition Examination Survey (NHANES) data from 2005 to 2018. METHODS: A general statistical description of the population included in the study was performed, and logistic analyses were used to explore the association between body mass index (BMI), waist circumference (WC), RFM and depression. Sensitivity analyses and restricted cubic spline (RCS) were also conducted to investigate the association between RFM and depression...
April 11, 2024: Journal of Affective Disorders
#12
JOURNAL ARTICLE
Haixu Ma, Zhuoyu Shi, Minjeong Kim, Bin Liu, Patrick J Smith, Yufeng Liu, Guorong Wu
Current diagnostic systems for Alzheimer's disease (AD) rely upon clinical signs and symptoms, despite the fact that the multiplicity of clinical symptoms renders various neuropsychological assessments inadequate to reflect the underlying pathophysiological mechanisms. Since putative neuroimaging biomarkers play a crucial role in understanding the etiology of AD, we sought to stratify the diverse relationships between AD biomarkers and cognitive decline in the aging population and uncover risk factors contributing to the diversities in AD...
April 11, 2024: NeuroImage
#13
JOURNAL ARTICLE
Mathiyazhagan Narayanan, K Suresh, Sami Al Obaid, Parameswari Alagarsamy, Cong-Kinh Nguyen
This investigation was performed to obtain a promising phytase enzyme producing yeast. In this regard, the PSM was used to isolate the phytase-producing Hanseniaspora guilliermondii S1 (MG663578) from sugarcane juice. The SSF optimum conditions for phytase generation were optimized using (OVAT) one-variable-at-a-time strategy using both Box-Behnken design and shake flask method (g/100ml: 0.05 yeast extract, 0.15 Peptone, 0.05 malt extract 0.50 dextrose, pH 5.8 and 28ᵒC). The protein model developed was shown to be adequate for phytase production (91% accuracy), with the greatest phytase productivity in shake flask with substrate jack fruit seed powder being 395± 0...
April 11, 2024: Environmental Research
#14
JOURNAL ARTICLE
Mehmood Yaqoob Janjua, Azaam Azfar, Zaheer Asghar, Khurrum Shehzad
This study explores bioremediation's effectiveness in reducing carbon emissions through the use of microalgae Chlorella vulgaris, known for capturing carbon dioxide and producing biomass. The impact of temperature and light intensity on productivity and carbon dioxide capture was investigated, and cultivation conditions were optimized in a photobioreactor using response surface methodology (RSM), analysis of variance (ANOVA), and deep neural networks (DNN). The optimal conditions determined were 28.74 °C and 225 μmol/m2 /s with RSM, and 29...
April 11, 2024: Bioresource Technology
#15
REVIEW
Hsin-Yen Yen, Chih Wei Huang, Huei-Ling Chiu, Grace Jin
OBJECTIVES: Depression and loneliness are challenges facing older residents living in long-term care facilities. Social robots might be a solution as nonpharmacologic interventions. The purpose of this study was to explore the effects of concrete forms of social robots on depression and loneliness in older residents in long-term care facilities by a systematic review and meta-analysis of randomized controlled trials. DESIGN: This is a systematic review and meta-analysis...
April 10, 2024: Journal of the American Medical Directors Association
#16
JOURNAL ARTICLE
Vanessa Mhanna, Pierre Barennes, Hélène Vantomme, Gwladys Fourcade, Nicolas Coatnoan, Adrien Six, David Klatzmann, Encarnita Mariotti-Ferrandiz
Accurate characterization and comparison of T cell receptor (TCR) repertoires from small biological samples present significant challenges. The main challenge is the low material input, which compromises the quality of bulk sequencing and hinders the recovery of sufficient TCR sequences for robust analyses. We aimed to address this limitation by implementing a strategic approach to pool homologous biological samples. Our findings demonstrate that such pooling indeed enhances the TCR repertoire coverage, particularly for cell subsets of constrained sizes, and enables accurate comparisons of TCR repertoires at different levels of complexity across T cell subsets with different sizes...
April 5, 2024: Cell Rep Methods
#17
JOURNAL ARTICLE
Joseph H Breeyear, Brian S Mautz, Jacob M Keaton, Jacklyn N Hellwege, Eric S Torstenson, Jingjing Liang, Michael J Bray, Ayush Giri, Helen R Warren, Patricia B Munroe, Digna R Velez Edwards, Xiaofeng Zhu, Chun Li, Todd L Edwards
Variability in quantitative traits has clinical, ecological, and evolutionary significance. Most genetic variants identified for complex quantitative traits have only a detectable effect on the mean of trait. We have developed the mean-variance test (MVtest) to simultaneously model the mean and log-variance of a quantitative trait as functions of genotypes and covariates by using estimating equations. The advantages of MVtest include the facts that it can detect effect modification, that multiple testing can follow conventional thresholds, that it is robust to non-normal outcomes, and that association statistics can be meta-analyzed...
April 9, 2024: American Journal of Human Genetics
#18
JOURNAL ARTICLE
Gregory R Roytman, Motasem Salameh, Sarah E Rizzo, Meera M Dhodapkar, Steven M Tommasini, Daniel H Wiznia, Brad J Yoo
BACKGROUND: Fixation of sustentaculum tali fractures is important to maintain the biomechanical function of the subtalar joint. A common method of fixation is securing the sustentacular fragment by way of a laterally based locking plate (LP). A medial approach with a single screw (MS) has been proposed as an alternative method of fixation. METHODS: Five pairs of formalin-preserved cadaveric ankles with the subtalar joint and interosseous ligaments intact ("osseous cadavers") and four pairs of fresh-frozen cadaveric ankles with soft-tissue preserved dissected from mid-tibia down ("soft tissue cadavers") were used in the study...
April 9, 2024: Injury
#19
JOURNAL ARTICLE
Yu Guo, Rui Bai, Tao Hong
Political conflicts or geopolitical tensions can create uncertainty in addressing climate change and environmental management in the Arctic. Dissecting how actors interact with each other and form networks is important for understanding ecological and environmental management challenges during geopolitical tensions, as well as promoting better governance. We construct transboundary networks for Arctic climate change governance (ACCG) from 2013 to 2021 based on the Global Database of Events, Language, and Tone (GDELT)...
April 12, 2024: Journal of Environmental Management
#20
JOURNAL ARTICLE
Renata Lumena Altruda Pucci, Anderson Martins da Silva, Rosimeire Simprini Padula
BACKGROUND: The Work Ability Index (WAI) assesses work demands, health status, and physical and mental resources. OBJECTIVES: To evaluate the measurement properties of the WAI, single-item work ability score (WAS), and short version for online applications. METHODS: One hundred three workers completed the 3 versions of the WAI and the Perceived Stress Scale (PSS-10) questionnaire. The reproducibility and construct validity of the 3 versions of the WAI and their concurrent validity with the PSS-10 were tested...
March 29, 2024: Brazilian Journal of Physical Therapy
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
