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https://www.readbyqxmd.com/read/29785287/lymph-node-dissection-during-sublobar-resection-why-when-and-how
#1
REVIEW
Pascal-Alexandre Thomas
Appropriate lymph node (LN) assessment is a hallmark of surgical quality of curative intent operations for non-small cell lung cancer (NSCLC). Even in the era of extensive pre-treatment work-up including routine PET-scanning and brain imaging, and selective invasive LN evaluation, unexpected LN metastases are found at surgery in more than 10% of patients with a cT1aN0 tumor. Systematic lymphadenectomy minimizes the risk of leaving tumor-LN behind and thus the risk of an incomplete resection, and provides the most truthful pTNM, which is decisive in directing adjuvant chemotherapy...
April 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29781194/paraneoplastic-autoimmune-encephalitis-associated-with-pleomorphic-lung-carcinoma-an-autopsy-case-report
#2
Takashi Ando, Yoji Goto, Kazuo Mano, Fumio Nomura, Masako Kurashige, Masafumi Ito, Maya Mimuro, Yasushi Iwasaki, Masahisa Katsuno, Mari Yoshida
A 64-year-old man was admitted with acute onset disturbed consciousness. Cerebrospinal fluid analysis revealed pleocytosis and elevated protein, with negative cultures and PCR. Serum antibodies for autoimmune encephalitis were also negative. Brain magnetic resonance imaging (MRI) was unremarkable, but whole-body CT scan showed a tumor in the left lower lung lobe. Bronchial brush cytology demonstrated clusters of malignant cells, and 18 F-fluorodeoxyglucose positron emission tomography showed multiple lesions and increased uptake in the lung tumor...
May 20, 2018: Neuropathology: Official Journal of the Japanese Society of Neuropathology
https://www.readbyqxmd.com/read/29775768/canine-pet-dog-tumor-microsurgery-and-intratumoral-concentration-and-safety-of-metronomic-chlorambucil-for-spontaneous-glioma-a-phase-i-clinical-trial
#3
R Timothy Bentley, Stephanie A Thomovsky, Margaret A Miller, Deborah W Knapp, Aaron A Cohen-Gadol
INTRODUCTION: Metronomic (daily low-dose) chlorambucil requires further study before implementation in human glioma. OBJECTIVE: Investigate the distribution and safety of metronomic chlorambucil in naturally occurring canine glioma. METHODS: Eight client-owned (pet) dogs with newly diagnosed spontaneous glioma were prospectively enrolled. Chlorambucil was administered preoperatively at 4 mg/m2 q 24hr for ≥ 3 days, and continued postoperatively until death or dose-limiting adverse events...
May 15, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29770486/direct-estimation-of-17-o-mr-images-diesis-for-quantification-of-oxygen-metabolism-in-the-human-brain-with-partial-volume-correction
#4
Dmitry Kurzhunov, Robert Borowiak, Marco Reisert, Ali Caglar Özen, Michael Bock
PURPOSE: To provide a data post-processing method that corrects for partial volume effects (PVE) and fast T2* decay in dynamic 17 O MRI for the mapping of cerebral metabolic rates of oxygen consumption (CMRO2 ). METHODS: CMRO2 is altered in neurodegenerative diseases and tumors and can be measured after 17 O gas inhalation using dynamic 17 O MRI. CMRO2 quantification is difficult because of PVE. To correct for PVE, a direct estimation of the MR images (DIESIS) method is proposed and used in 4 dynamic 17 O MRI data sets of a healthy volunteer acquired on a 3T MRI system...
May 16, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29769199/metabolic-imaging-of-the-human-brain-with-hyperpolarized-13c-pyruvate-demonstrates-13c-lactate-production-in-brain-tumor-patients
#5
Vesselin Z Miloushev, Kristin L Granlund, Rostislav Boltyanskiy, Serge K Lyashchenko, Lisa M DeAngelis, Ingo K Mellinghoff, Cameron W Brennan, Viviane Tabar, T Jonathan Yang, Andrei I Holodny, Ramon E Sosa, YanWei W Guo, Albert P Chen, James Tropp, Fraser Robb, Kayvan R Keshari
Hyperpolarized (HP) magnetic resonance imaging using [1-13C] pyruvate is a novel method that can characterize energy metabolism in the human brain and brain tumors. Here we present the first dynamically acquired human brain HP 13C metabolic spectra and spatial metabolite maps in cases of both untreated and recurrent tumors. In vivo production of HP lactate from HP pyruvate by tumors was indicative of altered cancer metabolism, while production of HP lactate in the entire brain was likely due to baseline metabolism...
May 16, 2018: Cancer Research
https://www.readbyqxmd.com/read/29747315/-value-of-pet-ct-in-the-prognosis-of-extranodal-nk-t-cell-lymphoma
#6
G H Dong, Y Li, H F Wan, C Y He, L Yang, J W Wang, L P Gong, Y H Zhao, Z F Gao, H G Liu
Objective: To explore the value of Positron-Emission Tomography/Computed Tomography (PET/CT) in the prognosis of extranodal NK/T cell lymphoma. Methods: The patients of NK/T cell lymphoma diagnosed from January 2007 to July 2016 in Department of Pathology of Beijing Tongren Hospital were enrolled in this study. Seventy-two in-hospital patients were examined on the invasion of adjecent tissue or organ by PET/CT. The PET/CT results were analyzed retrospectively. Kaplan-Meier method was used to analyze the prognostic value of the positive results by PET/CT on overall survival (OS)...
April 24, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29742600/incidental-detection-of-meningioma-by-18f-fmau-pet-ct-in-a-patient-with-suspected-prostate-cancer
#7
Bino Varghese, Erik Velez, Bhushan Desai, Hossein Jadvar
We report on an incidental detection of a meningioma on [F]-2'-fluoro-5-methyl-1-beta-D-arabinofuranosyluracil (F-FMAU) PET/CT scan that was performed during a prospective investigation of F-FMAU PET/CT for targeted biopsy of potential sites of tumor in men with suspected prostate cancer based on elevated prostate-specific antigen level. Neither prostate multiparamteric MRI nor F-FMAU PET/CT localized small volume Gleason 3 + 3 tumor deposits. However, an incidental focal high accumulation of F-FMAU was observed in high right parietal lobe that displayed characteristics of a meningioma on a subsequent brain MRI...
May 7, 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29728514/positron-emission-tomography-of-adoptively-transferred-chimeric-antigen-receptor-t-cells-with-zirconium-89-oxine
#8
Michael Ryan Weist, Renate Starr, Brenda Aguilar, Junie Chea, Joshua Miles, Erasmus Poku, Ethan Gerdts, Xin Yang, Saul Priceman, Stephen Forman, David Colcher, Christine Brown, John Shively
CAR T cell therapy is a promising clinical approach for reducing tumor progression and prolonging patient survival. However, improvements in both the safety and potency of CAR T cell therapy demand quantitative imaging techniques to determine the distribution of cells following adoptive transfer. The purpose of this study is to optimize zirconium-89-oxine (89 Zr-oxine) labeling of chimeric antigen receptor (CAR) T cells and evaluate positron emission tomography (PET) as a platform for imaging adoptively transferred CAR T cells...
May 4, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29721096/first-in-human-study-of-pet-and-optical-dual-modality-image-guided-surgery-in-glioblastoma-using-68-ga-irdye800cw-bbn
#9
Deling Li, Jingjing Zhang, Chongwei Chi, Xiong Xiao, Junmei Wang, Lixin Lang, Iqbal Ali, Gang Niu, Liwei Zhang, Jie Tian, Nan Ji, Zhaohui Zhu, Xiaoyuan Chen
Purpose : Despite the use of fluorescence-guided surgery (FGS), maximum safe resection of glioblastoma multiforme (GBM) remains a major challenge. It has restricted surgeons between preoperative diagnosis and intraoperative treatment. Currently, an integrated approach combining preoperative assessment with intraoperative guidance would be a significant step in this direction. Experimental design : We developed a novel 68 Ga-IRDye800CW-BBN PET/near-infrared fluorescence (NIRF) dual-modality imaging probe targeting gastrin-releasing peptide receptor (GRPR) in GBM...
2018: Theranostics
https://www.readbyqxmd.com/read/29713958/noise-induced-variability-of-immuno-pet-with-zirconium-89-labeled-antibodies-an-analysis-based-on-count-reduced-clinical-images
#10
Yvonne W S Jauw, Dennis F Heijtel, Josée M Zijlstra, Otto S Hoekstra, Henrica C W de Vet, Danielle J Vugts, Henk M Verheul, Ronald Boellaard, Sonja Zweegman, Guus A M S van Dongen, C Willemien Menke-van der Houven van Oordt, Adriaan A Lammertsma, Marc C Huisman
PURPOSE: Positron emission tomography (PET) with Zirconium-89 (Zr-89)-labeled antibodies can be used for in vivo quantification of antibody uptake. Knowledge about measurement variability is required to ensure correct interpretation. However, no clinical studies have been reported on measurement variability of Zr-89 immuno-PET. As variability due to low signal-to-noise is part of the total measurement variability, the aim of this study was to assess noise-induced variability of Zr-89 -immuno-PET using count-reduced clinical images...
April 30, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/29713762/prolonged-survival-in-secondary-glioblastoma-following-local-injection-of-targeted-alpha-therapy-with-213-bi-substance-p-analogue
#11
Leszek Krolicki, Frank Bruchertseifer, Jolanta Kunikowska, Henryk Koziara, Bartosz Królicki, Maciej Jakuciński, Dariusz Pawlak, Christos Apostolidis, Saed Mirzadeh, Rafał Rola, Adrian Merlo, Alfred Morgenstern
BACKGROUND: Glioblastoma multiforme (GBM), the most common malignant brain tumor, mainly manifests as a primary de novo and less frequently as a secondary glial neoplasm. GBM has been demonstrated to overexpress the NK-1 receptor and substance P can be used as a ligand for targeted therapy. Alpha emitters, e.g. 213 Bi, that deposit their high energy within a short range allow the selective irradiation of tumor cells while sparing adjacent neuronal structures. MATERIAL AND METHODS: Among 50 glioma patients of different subtypes that have to date been treated with targeted alpha therapy at the Medical University Warsaw, we report here the data on nine patients with secondary GBM...
April 30, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29708403/detection-of-unknown-primary-tumor-in-patients-presented-with-brain-metastasis-by-f-18-fluorodeoxyglucose-positron-emission-tomography-computed-tomography
#12
Zehra Pınar Koç, Pelin Özcan Kara, Ahmet Dağtekin
AIM:  F-18 fluorodeoxyglucose (FDG) PET/CT has several advantages in diagnosis of cancer of unknown primary with reported incremental diagnostic value. In this study, we evaluated the patients who were presented with multiple brain metastasis and unknown primary tumor. MATERIALS & METHODS: 31 patients (17 males, 14 females; mean: 56.1 ± 14.22 years old) with diagnosis of brain metastasis according to histopathology and/or MRI were included into this retrospective study...
April 30, 2018: CNS Oncology
https://www.readbyqxmd.com/read/29702548/the-effect-of-pet-therapy-and-artist-interactions-on-quality-of-life-in-brain-tumor-patients-a-cross-section-of-art-and-medicine-in-dialog
#13
Stefan Petranek, Jennifer Pencek, Mahua Dey
With the evolution of modern medical treatment strategies, there also comes the realization that many times we reach a point where traditional goals of medical care, such as overall survival or disease-free survival, are not realistic goals for many patients facing devastating illnesses. One such disease is malignant primary brain tumors, known as malignant glioma (MG). With median survival of only 20.9 months following best available standard of care treatment strategies, including surgery, chemotherapy, radiation, and tumor treating fields, MG is one of the deadliest malignancies of the modern era...
April 27, 2018: Behavioral Sciences
https://www.readbyqxmd.com/read/29696947/the-role-of-amino-acid-pet-in-the-light-of-the-new-who-classification-2016-for-brain-tumors
#14
Bogdana Suchorska, Nathalie L Albert, Elena K Bauer, Jörg-Christian Tonn, Norbert Galldiks
INTRODUCTION: Since its introduction in 2016, the revision of the World Health Organization (WHO) classification of central nervous system tumours has already changed the diagnostic and therapeutic approach in glial tumors. Blurring the lines between entities formerly labelled as "high-grade" or "low-grade", molecular markers define distinct biological subtypes with different clinical course. This new classification raises the demand for non-invasive imaging methods focussing on depicting metabolic processes...
April 26, 2018: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29692922/-18-f-fdopa-pet-mri-for-monitoring-early-response-to-bevacizumab-in-children-with-recurrent-brain-tumors
#15
Karen Gauvain, Maria Rosana Ponisio, Amy Barone, Michael Grimaldi, Ephraim Parent, Hayden Leeds, Manu Goyal, Joshua Rubin, Jonathan McConathy
Background: Noninvasively predicting early response to therapy in recurrent pediatric brain tumors provides a challenge. 3,4-dihydroxy-6-[18 F]fluoro-L-phenylalanine (18 F-FDOPA) PET/MRI has not been previously studied as a tool to evaluate early response to antiangiogenic therapy in children. The purpose of this study was to evaluate the safety and feasibility of using 18 F-FDOPA PET/MRI to assess response to bevacizumab in children with relapsed brain tumors. Materials and Methods: Six patients with recurrent gliomas (5 low-grade, 1 high-grade) planned to undergo treatment with bevacizumab were enrolled...
March 2018: Neuro-oncology Practice
https://www.readbyqxmd.com/read/29687323/investigation-of-cis-4-18-f-fluoro-d-proline-uptake-in-human-brain-tumors-after-multimodal-treatment
#16
Antoine Verger, Gabriele Stoffels, Norbert Galldiks, Philipp Lohmann, Antje Willuweit, Bernd Neumaier, Stefanie Geisler, Karl-Josef Langen
PURPOSE: Cis-4-[18 F]fluoro-D-proline (D-cis-[18 F]FPro) has been shown to pass the intact blood-brain barrier and to accumulate in areas of secondary neurodegeneration and necrosis in the rat brain while uptake in experimental brain tumors is low. This pilot study explores the uptake behavior of D-cis-[18 F]FPro in human brain tumors after multimodal treatment. PROCEDURES: In a prospective study, 27 patients with suspected recurrent brain tumor after treatment with surgery, radiotherapy, and/or chemotherapy (SRC) were investigated by dynamic positron emission tomography (PET) using D-cis-[18 F]FPro (22 high-grade gliomas, one unspecified glioma, and 4 metastases)...
April 23, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/29670367/pet-ct-evaluation-of-the-curative-effect-of-crizotinib-on-malignant-myofibroblastoma-with-rare-mutation-of-alk-r401-a-case-report-and-literature-review
#17
Li Yang, Yufeng Wu, Hong Tang, Jiuzhou Zhao, Dongdong Zhao, Sen Yang, Qiming Wang
Objective: The purpose of this article is to explore the targeted treatment of malignant myofibroblastoma and evaluate the role of neoplasm metabolite markers in the evaluation of efficacy after targeted therapy. Method: This report described a case of myofibroblastic sarcoma with rare mutation of ALK R401 in a 58-year-old man prescribed with crizotinib, to evaluate its curative effect by positron emission tomography coupled with computed tomography (PET-CT). After the progressive disease in the brain, bevacizumab combined with crizotinib was administered...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29660639/elevated-tumor-necrosis-factor-alpha-receptor-subtype-1-and-the-association-with-abnormal-brain-function-in-treatment-resistant-depression
#18
Mao-Hsuan Huang, Mu-Hong Chen, Pei-Chi Tu, Ya Mei Bai, Tung-Ping Su, Bang-Hung Yang, Ren-Shyan Liu, Cheng-Ta Li
BACKGROUND: Major depressive disorder (MDD) patients have shown elevated plasma levels of pro-inflammatory biomarkers compared to healthy controls. We hypothesized increased serum tumor necrosis factor-alpha receptor subtype 1 (TNF-α R1) is more associated with impaired brain function in patients with treatment-resistant depression (TRD) than those without TRD. METHODS: 34 MDD patients and 34 healthy subjects were recruited and we separated MDD patients to TRD group (n = 20) and non-TRD (n = 14) group...
April 6, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29652908/automatic-lesion-detection-and-segmentation-of-18f-fet-pet-in-gliomas-a-full-3d-u-net-convolutional-neural-network-study
#19
Paul Blanc-Durand, Axel Van Der Gucht, Niklaus Schaefer, Emmanuel Itti, John O Prior
INTRODUCTION: Amino-acids positron emission tomography (PET) is increasingly used in the diagnostic workup of patients with gliomas, including differential diagnosis, evaluation of tumor extension, treatment planning and follow-up. Recently, progresses of computer vision and machine learning have been translated for medical imaging. Aim was to demonstrate the feasibility of an automated 18F-fluoro-ethyl-tyrosine (18F-FET) PET lesion detection and segmentation relying on a full 3D U-Net Convolutional Neural Network (CNN)...
2018: PloS One
https://www.readbyqxmd.com/read/29650831/-four-cases-of-resected-cn2-stage-iii-a-non-small-cell-lung-cancer-after-induction-chemotherapy
#20
Hideoki Yokouchi, Masaki Miyazaki, Takeaki Miyamoto, Takafumi Minami, Fumio Tsuji, Kazuhito Oishi, Chikara Ebisui
Four patients with non-small-cell lung cancer(NSCLC), diagnosed with cN2 stage III A disease, by using CT and FDG-PET/ CT imaging, received 2 or 3 courses of platinum-based combination chemotherapy.The patients achieved partial response after chemotherapy and underwent surgery.Complete tumor resection was performed via upper lobectomy for 3 patients, but in 1 patient, interlobar metastatic lymph nodes remained after middle and lower bilobectomy.Two courses of postoperative chemotherapy were administered to 3 patients, but 1 patient could not receive postoperative chemotherapy due to complications...
April 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
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