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https://www.readbyqxmd.com/read/29349488/one-step-synthesis-of-an-18f-labeled-boron-derived-methionine-analog-a-substitute-for-11c-methionine
#1
EDITORIAL
Zhen Liu, Emily B Ehlerding, Weibo Cai, Xiaoli Lan
Amino acid-based tracers have been extensively investigated for positron emission tomography (PET) imaging of brain tumors, and 11C-methionine (11C-MET) is one of the most extensively investigated. However, widespread clinical use of 11C-MET is challenging due to the short half-life of 11C and low radiolabeling yield. In this issue of the European Journal of Nuclear Medicine and Molecular Imaging, Yang and colleagues report an 18F-labeled boron-derived methionine analog, 18F-B-MET, as a potential substitute for 11C-MET in PET imaging of glioma...
January 18, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29330810/correlation-of-glioma-proliferation-and-hypoxia-by-luciferase-magnetic-resonance-and-positron-emission-tomography-imaging
#2
Michael Karsy, David L Gillespie, Kevin P Horn, Lance D Burrell, Jeffery T Yap, Randy L Jensen
Gliomas are the most common type of primary, malignant brain tumor and significantly impact patients, who have a median survival of ~1 year depending on mutational background. Novel imaging modalities such as luciferase bioluminescence, micro-magnetic resonance imaging (micro-MRI), micro-computerized tomography (micro-CT), and micro-positron emission tomography (micro-PET) have expanded the portfolio of tools available to study this disease. Hypoxia, a key oncogenic driver of glioma and mechanism of resistance, can be studied in vivo by the concomitant use of noninvasive MRI and PET imaging...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29301781/addition-of-amide-proton-transfer-imaging-to-fdg-pet-ct-improves-diagnostic-accuracy-in-glioma-grading-a-preliminary-study-using-the-continuous-net-reclassification-analysis
#3
A Sakata, T Okada, Y Yamamoto, Y Fushimi, T Dodo, Y Arakawa, Y Mineharu, B Schmitt, S Miyamoto, K Togashi
BACKGROUND AND PURPOSE: Amide proton transfer imaging has been successfully applied to brain tumors, however, the relationships between amide proton transfer and other quantitative imaging values have yet to be investigated. The aim was to examine the additive value of amide proton transfer imaging alongside [18F] FDG-PET and DWI for preoperative grading of gliomas. MATERIALS AND METHODS: Forty-nine patients with newly diagnosed gliomas were included in this retrospective study...
January 4, 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29285548/preclinical-evaluation-of-an-18f-trifluoroborate-methionine-derivative-for-glioma-imaging
#4
Xiangyu Yang, Zhibo Liu, Huimin Zhang, Zhu Li, Jeeva P Munasinghe, Gang Niu, Gaojun Teng, Xiaoyuan Chen
PURPOSE: 11C-methionine (MET) is one of the most commonly used amino acid tracers for PET imaging of brain tumors. In this study, we report an 18F-labeled boron-derived methionine analogue, denoted as 18F-B-MET, as a potential substitute of 11C-MET for glioma PET imaging. METHODS: 19F-B-MET was synthesized from readily available chemicals according to our previous publication. For kit development, 19F-B-MET was aliquoted in quantities of 10 nmol for on-demand one-step labeling...
December 29, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29282517/11c-met-pet-mri-for-detection-of-recurrent-glioma
#5
C Deuschl, J Kirchner, T D Poeppel, B Schaarschmidt, S Kebir, N El Hindy, J Hense, H H Quick, M Glas, K Herrmann, L Umutlu, C Moenninghoff, A Radbruch, M Forsting, M Schlamann
INTRODUCTION: Radiological assessment of brain tumors is widely based on the Radiology Assessment of Neuro-Oncology (RANO) criteria that consider non-specific T1 and T2 weighted images. Limitation of the RANO criteria is that they do not include metabolic imaging techniques that have been reported to be helpful to differentiate treatment related changes from true tumor progression. In the current study, we assessed if the combined use of MRI and PET with hybrid 11C-MET PET/MRI can improve diagnostic accuracy and diagnostic confidence of the readers to differentiate treatment related changes from true progression in recurrent glioma...
December 28, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29280066/diagnostic-accuracy-of-11c-methionine-pet-in-detecting-neuropathologically-confirmed-recurrent-brain-tumor-after-radiation-therapy
#6
Annika Kits, Heather Martin, Alejandro Sanchez-Crespo, Anna F Delgado
OBJECTIVE: This study aims to determine the diagnostic test accuracy (DTA) of 11C-methionine (MET) PET in the discrimination between recurrent tumor and radiation-induced injury in neuropathologically confirmed cases. METHODS: A retrospective cohort of 30 patients with previously irradiated intracranial tumors (23 gliomas, 6 metastases, and 1 meningioma) was included. All patients underwent a preoperative MET PET and postoperative neuropathological analysis. Maximum and mean standardized uptake values (SUV) were obtained in the lesion, in the contralateral mirror region, and in the contralateral frontal cortex...
December 26, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/29279695/undiagnosed-esophageal-adenocarcinoma-presenting-as-multiple-brain-metastases
#7
Vincent Grzywacz, Ernie Balcueva
Brain metastases from gastrointestinal malignancies are exceedingly rare occurrences that carry a very poor prognosis. This holds especially true in cases where brain metastases from esophageal primaries are the initial presentation of a previously unidentified gastrointestinal malignancy. Our patient, a 60-year-old male with a past history of a right temporal teratoma, family history of breast cancer, and no smoking history, presented with a chief complaint of recurrent headaches. His history of present illness and physical examination included a two-month history of frontal headache, progressive fatigue, and unintentional weight loss...
September 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/29275040/radiosynthesis-and-modified-quality-control-of-o-2-18f-fluoroethyl-l-tyrosine-18f-fet-for-brain-tumor-imaging
#8
Ibrahim Saber Siddiq, Shoukar Tawfik Atwa, Sayed Ahmed Shama, Magdy Hafez Eltaoudy, Walid Mohamed Omar
O-(2-[18F]fluoroethyl)-L-tyrosine ([18F]FET) is the most promising radio-labeled amino acid tracer for brain tumor imaging due to the limitation of 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) and L-methyl-[11C]methionine (11C-MET). However, it has some limitations in radiosynthesis and related quality control that make it less frequently used in many PET centers, in this study, we report a new modification of [18F]FET production using a commercially available fully automated GRP SCINTOMICS module overcoming some of the existing limitations along with a suggestion of a simplified quality control procedure with special focus placed on enantiomeric and radiochemical purity...
December 13, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/29261628/subacute-cerebellar-infarction-with-uptake-on-68ga-prostate-specific-membrane-antigen-pet-ct
#9
Geon Oh, Kenneth Miles
We report a case of subacute cerebellar infarction mimicking metastasis on prostate-specific membrane antigen (PSMA) PET/CT. A 77-year-old man with prostate cancer treated with androgen deprivation therapy and radiotherapy with rising prostate-specific antigen was referred for Ga-PSMA PET/CT. Apart from PSMA-expressing tumor of the left prostate, PSMA PET/CT demonstrated radiotracer uptake in the right cerebellar hemisphere, corresponding to a site of subacute infarction demonstrated on an MRI of the brain performed 35 days previously...
December 19, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29250326/palliative-treatment-efficacy-of-glucose-inhibition-combined-with-chemotherapy-for-non-small-cell-lung-cancer-with-widespread-bone-and-brain-metastases-a-case-report
#10
Yongping Liu, Yaping Zhang, Xibao Mao, Qiufeng Qi, Ming Zhu, Changsong Zhang, Xuefeng Pan, Yang Ling
Otto Warburg observed in 1924 that cancer cells were dependent exclusively on glycolysis for the production of energy even in the presence of oxygen (the 'Warburg effect'). Consequently, cancer cells require ~19 times more glucose uptake to obtain equivalent amounts of energy as normal cells. The Warburg effect is the scientific basis for positron emission tomography (PET), which has markedly improved cancer detection. During chemotherapy, cancer cells may upregulate their expression of multi-drug resistance proteins and ultimately cause treatment failure...
December 2017: Biomedical Reports
https://www.readbyqxmd.com/read/29245258/primary-atrial-fibromyxosarcoma-with-multiple-system-metastases-a-case-report
#11
Jingping Qiu, Lingrong Tang, Yang Han, Chun Wang, Tianxiang Gu, Guang Li
RATIONALE: Fibromyxosarcoma is common in head and neck, vessel, omentum, and reproductive system, with low-grade malignant behavior. However, primary atrial fibromyxosarcoma with highly malignant behavior is extremely rare. PATIENT CONCERNS: A 34-year-old female presented with oppression in the chest, short breath, and onset of headache as initial symptoms. The preoperative echocardiogram showed a medium-size echogenic mass close to the posterior leaflet of the mitral valve in the left atrium...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29242363/diagnostic-accuracy-of-amino-acid-and-fdg-pet-in-differentiating-brain-metastasis-recurrence-from-radionecrosis-after-radiotherapy-a-systematic-review-and-meta-analysis
#12
H Li, L Deng, H X Bai, J Sun, Y Cao, Y Tao, L J States, M D Farwell, P Zhang, B Xiao, L Yang
BACKGROUND: Current studies that analyze the usefulness of amino acid and FDG-PET in distinguishing brain metastasis recurrence and radionecrosis after radiation therapy are limited by small cohort size. PURPOSE: Our aim was to assess the diagnostic accuracy of amino acid and FDG-PET in differentiating brain metastasis recurrence from radionecrosis after radiation therapy. DATA SOURCES: Studies were retrieved from PubMed, Embase, and the Cochrane Library...
December 14, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29217875/deep-auto-context-convolutional-neural-networks-for-standard-dose-pet-image-estimation-from-low-dose-pet-mri
#13
Lei Xiang, Yu Qiao, Dong Nie, Le An, Qian Wang, Dinggang Shen
Positron emission tomography (PET) is an essential technique in many clinical applications such as tumor detection and brain disorder diagnosis. In order to obtain high-quality PET images, a standard-dose radioactive tracer is needed, which inevitably causes the risk of radiation exposure damage. For reducing the patient's exposure to radiation and maintaining the high quality of PET images, in this paper, we propose a deep learning architecture to estimate the high-quality standard-dose PET (SPET) image from the combination of the low-quality low-dose PET (LPET) image and the accompanying T1-weighted acquisition from magnetic resonance imaging (MRI)...
December 6, 2017: Neurocomputing
https://www.readbyqxmd.com/read/29215406/focal-18f-dopa-uptake-in-brain-parenchyma-surrounding-developmental-venous-anomalies
#14
Lee Condon, John Blazak
We report the finding of increased F-DOPA uptake within parenchyma surrounding a developmental venous anomaly, found incidentally in a 64-year-old woman undergoing PET scan to assess for Parkinson's disease. Not identified on previous T1/T2 MRI, susceptibility-weighted imaging MRI performed post-PET scan demonstrated the presence of developmental venous anomaly within the left cerebellar hemisphere. Focal uptake of F-DOPA may suggest the presence of a brain tumor and prompt invasive diagnostic investigations...
December 5, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29175983/molecular-imaging-of-abcb1-abcg2-inhibition-at-the-human-blood-brain-barrier-using-elacridar-and-11c-erlotinib-pet
#15
Remy B Verheijen, Maqsood M Yaqub, Emilia Sawicki, Olaf van Tellingen, Adriaan A Lammertsma, Bastiaan Nuijen, Jan H M Schellens, Jos H Beijnen, Alwin D R Huitema, N Harry Hendrikse, Neeltje Steeghs
Transporters such as ABCB1 and ABCG2 limit the exposure of several anti-cancer drugs to the brain, leading to suboptimal treatment in the central nervous system. The purpose of this study was to investigate the effects of the ABCB1/ABCG2 inhibitor elacridar on erlotinib brain uptake using 11C-erlotinib PET. Methods: Elacridar and cold erlotinib were administered orally to wild type (WT) and Abcb1a/b;Abcg2 knockout mice. In addition, brain uptake was measured using 11C-erlotinib imaging and ex vivo scintillation counting in knockout and WT mice...
November 24, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29175980/glioma-survival-prediction-with-the-combined-analysis-of-in-vivo-11c-met-pet-ex-vivo-and-patient-features-by-supervised-machine-learning
#16
Laszlo Papp, Nina Poetsch, Marko Grahovac, Victor Schmidbauer, Adelheid Woehrer, Matthias Preusser, Markus Mitterhauser, Barbara Kiesel, Wolfgang Wadsak, Thomas Beyer, Marcus Hacker, Tatjana Traub-Weidinger
Gliomas are the most common types of tumors in the brain. While the definite diagnosis is routinely made ex vivo by histopathologic and molecular examination, diagnostic work-up of patients with suspected glioma is mainly done by using magnetic resonance imaging (MRI). Nevertheless, L-S-methyl-11C-methionine (11C-MET) Positron Emission Tomography (PET) holds a great potential in characterization of gliomas. The aim of this study was to establish machine learning (ML) driven survival models for glioma built on 11C-MET-PET, ex vivo and patient characteristics...
November 24, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29172209/-clinical-applications-of-positron-emission-tomography-for-neurosurgery-4-applications-of-positron-emission-tomography-for-assessing-brain-tumors
#17
Shigeru Yamaguchi
No abstract text is available yet for this article.
November 2017: No Shinkei Geka. Neurological Surgery
https://www.readbyqxmd.com/read/29168082/a-pilot-study-of-neuropsychological-functions-apoe-and-amyloid-imaging-in-patients-with-gliomas
#18
D D Correa, M Kryza-Lacombe, X Zhou, R E Baser, B J Beattie, Z Beiene, J Humm, L M DeAngelis, I Orlow, W Weber, J Osborne
Brain tumor patients treated with radiotherapy (RT) often develop cognitive dysfunction, and recent studies suggest that the APOE ε-4 allele may influence cognitive outcome. The ε-4 allele is known to promote beta (β) amyloid deposition in the cortex, and preliminary evidence suggests that RT may be associated with this process. However, it is unknown whether β-amyloid accumulation contributes to treatment neurotoxicity. In this pilot study, we assessed neuropsychological functions and β-amyloid retention using (18)F-florbetaben (FBB) PET in a subset of brain tumor patients who participated in our study of APOE polymorphisms and cognitive functions...
November 22, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29164057/diagnostic-and-prognostic-significance-of-methionine-uptake-and-methionine-positron-emission-tomography-imaging-in-gliomas
#19
REVIEW
Kamalakannan Palanichamy, Arnab Chakravarti
The present most common image diagnostic tracer in clinical practice for glioma is (18)F-fluorodeoxyglucose (FDG) positron emission tomography (PET) for brain tumors diagnosis and prognosis. PET is a promising molecular imaging technique, which provides real-time information on the metabolic behavior of the tracer. The diffusive nature of glioblastoma (GBM) and heterogeneity often make the radiographic detection by FDG-PET inaccurate, and there is no gold standard. FDG-PET often leads to several controversies in making clinical decisions due to their uptake by normal surrounding tissues, and pose a challenge in delineating treatment-induced necrosis, edema, inflammation, and pseudoprogression...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/29162527/usefulness-of-fdg-pet-in-comparison-with-methionine-pet-in-differentiating-solid-hemangioblastoma-from-adult-cerebellar-tumors
#20
Yoshinobu Takahashi, Akimasa Nishio, Daisuke Yamamoto, Hajime Kamada, Naoya Hashimoto
BACK GROUND AND PURPOSE: Among adults with posterior fossa tumors, intraaxial location of the tumors is less common than extraaxial. Moreover, the differential diagnosis of a single cerebellar tumor in adult is sometimes difficult by conventional MRI. We aimed to report the findings of PET using FDG and methionine in adult patients with intraaxial and solitary metastatic brain tumors. MATERIALS AND METHODS: FDG-PET was performed on 12 patients with posterior fossa tumors: four had solid hemangioblastoma (HB), three had primary central nervous system lymphomas, one had a glioblastoma, and four had single metastatic brain tumors (METs)...
November 18, 2017: World Neurosurgery
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