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Coronary microcirculation

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https://www.readbyqxmd.com/read/28191873/orbital-atherectomy-treatment-of-severely-calcified-coronary-lesions-in-patients-with-impaired-left-ventricular-ejection-fraction-one-year-outcomes-from-the-orbit-ii-study
#1
Michael S Lee, Brad J Martinsen, Richard Shlofmitz, Evan Shlofmitz, Arthur C Lee, Jeffrey Chambers
AIMS: Percutaneous coronary intervention (PCI) of severe coronary artery calcification (CAC) is challenging. The ORBIT II study demonstrated the safety and efficacy of orbital atherectomy (OA) in patients with severe CAC. Microparticulate liberated during OA may disturb coronary microcirculation. We evaluated OA treatment in patients with left ventricular systolic dysfunction. METHODS AND RESULTS: Patients were grouped by left ventricular ejection fraction (LVEF): 26-40% (n=33), 41-50% (n=90), and >50% (n=314)...
February 14, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28180196/serial-transthoracic-coronary-doppler-shows-complete-reversibility-of-microvascular-obstruction-pattern-at-one-month-after-reperfused-acute-myocardial-infarction
#2
Camelia Diana Ober, Mihai Claudiu Ober, Adrian Corneliu Iancu
: "No reflow" phenomenon is a common complication with significant prognostic repercussions after reperfused acute myocardial infarction. Previous studies have shown the feasibility and prognostic significance of coronary microcirculation assessment by transthoracic Doppler of left anterior descending artery (LAD). The aim of the study was to evaluate the time course of the coronary microcirculation status after acute anterior myocardial infarction reperfused by primary angioplasty with stent on LAD...
January 31, 2017: Medical Ultrasonography
https://www.readbyqxmd.com/read/28094311/evidence-of-microvascular-changes-in-the-retina-following-kawasaki-disease
#3
Katherine Y H Chen, David P Burgner, Tien Y Wong, Seang Mei Saw, Swee Chye Quek, Audrey Y C Pang, Seo Wei Leo, Inez B Wong, Diana Zannino, Nigel Curtis, Michael Cheung, Carol Y Cheung, Terence C W Lim
It is unclear whether all children with Kawasaki disease (KD) have increased later cardiovascular risk. The retinal microvasculature reflects changes in the microcirculation and is associated with traditional cardiovascular risk factors and events. The aim of this study was to investigate retinal microvascular parameters in two populations of patients with previous KD and control participants. We performed case-control studies of 116 (57 patients and 59 control participants) Australian and 156 (78 patients and 78 control participants) Singaporean individuals, at least two years since their acute illness...
January 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28028974/myocardial-ischaemia-coronary-atherosclerosis-and-pulmonary-pressure-elevation-in-antiphospholipid-syndrome-patients
#4
Agnieszka Padjas, Wojciech Płazak, Magdalena Celińska-Lowenhoff, Adam Mazurek, Carlo Perricone, Piotr Podolec, Jacek Musiał
BACKGROUND: Thrombotic events in antiphospholipid syndrome (APS) involve venous and arterial circulation with the possible involvement of coronary or pulmonary microcirculation. OBJECTIVES: To evaluate the influence of antiphospholipid antibodies (aPL) and on myocardial ischaemia assessed by single-photon emission computerized tomography (SPECT), coronary atherosclerosis assessed by multidetector computerized tomography (MDCT) and pulmonary pressure assessed by transthoracic echocardiography (TTE) in patients with primary antiphospholipid syndrome (PAPS)...
November 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/27983545/comparison-of-the-simple-red-blood-cell-adhesiveness-aggregation-test-with-the-laser-assisted-optical-rotational-cell-analyzer-red-blood-cell-aggregation-in-patients-with-coronary-artery-disease-and-a-healthy-control-group
#5
Heike Preibsch, Stefanie Keymel, Malte Kelm, Theodor Baars, Petra Kleinbongard
BACKGROUND: Red blood cell (RBC) aggregation influences blood flow properties, impacts blood microcirculation and consequently oxygen delivery. Different methods are established to determine RBC aggregation: under static conditions (i.e. the RBC adhesiveness/aggregation test (EAAT)) or under shear conditions (i.e. the laser-assisted optical rotational cell analyzer (LORCA)). OBJECTIVE: Comparison of these two different methods in detecting the RBC aggregation of patients with coronary artery disease (CAD) and of healthy controls...
December 14, 2016: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/27976459/current-perspectives-in-coronary-microvascular-dysfunction
#6
REVIEW
Joy S Shome, Divaka Perera, Sven Plein, Amedeo Chiribiri
The coronary arterial system consists of large epicardial coronary arteries, pre-arterioles, and arterioles, which together closely regulate CBF. Structural, functional, and extravascular abnormalities of the microcirculation lead to CMD. CMD can present with symptoms suggestive of CAD, often in the absence of significant obstructive epicardial CAD. Conventional invasive angiography does not allow direct visualization of the microcirculation. Invasive indices, such as CBF and CFR, and non-invasive imaging modalities, such as CMR and PET, can be used to quantify absolute MBF and enable a direct and accurate assessment of coronary microvascular function...
January 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/27970411/tct-236-effects-of-orbital-versus-rotational-atherectomy-facilitated-pci-on-the-coronary-microcirculation
#7
Keyvan Karimi Galougahi, Navdeep Bhatti, Richard Shlofmitz, Philippe Généreux, Jeffrey Moses, Ajay Kirtane, Gregg Stone, Gary Mintz, Dimitri Karmpaliotis, Akiko Maehara, Martin Leon, Ziad Ali
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27930353/bimodal-pattern-of-coronary-microvascular-involvement-in-diabetes-mellitus
#8
Murat Sezer, Mehmet Kocaaga, Emre Aslanger, Adem Atici, Ahmet Demirkiran, Zehra Bugra, Sabahattin Umman, Berrin Umman
BACKGROUND: The contribution of functionally disturbed coronary autoregulation and structurally impaired microvascular vasodilatory function to reduced coronary flow velocity reserve, reflecting impaired coronary microcirculation in diabetes mellitus (DM), has not been clearly elucidated. The objective of this study was to identify the mechanism of coronary microvascular impairment in DM in relation to duration of disease. METHODS AND RESULTS: Coronary flow velocities in the anterior descending coronary artery were assessed by transthoracic echocardiography following angiography revealing normal epicardial coronary arteries in 55 diabetic and 47 nondiabetic patients...
November 14, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27926994/microvessels-of-the-heart-formation-regeneration-and-dysfunction
#9
EDITORIAL
Ioakim Spyridopoulos, Helen M Arthur
This issue of microcirculation focusses on the special topic of "microvessels of the heart" and contains five state-of-the-art reviews and one expert article that reflect current efforts to address the major gaps in our understanding of these key microvessels. In the adult heart, most attention until recently (especially among the clinical cardiology community) has been given to the main coronary arteries, which are the culprit vessels in patients with coronary artery disease, including its most serious manifestation, acute MI...
January 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/27872049/contribution-of-kv1-5-channel-to-hydrogen-peroxide-induced-human-arteriolar-dilation-and-its-modulation-by-coronary-artery-disease
#10
Yoshinori Nishijima, Sheng Cao, Dawid S Chabowski, Ankush Korishettar, Alyce Ge, Xiaodong Zheng, Rodney Sparapani, David D Gutterman, David X Zhang
RATIONALE: Hydrogen peroxide (H2O2) regulates vascular tone in the human microcirculation under physiological and pathophysiological conditions. It dilates arterioles by activating large-conductance Ca(2+)-activated K(+) channels in subjects with coronary artery disease (CAD), but its mechanisms of action in subjects without CAD (non-CAD) when compared with those with CAD remain unknown. OBJECTIVE: We hypothesize that H2O2-elicited dilation involves different K(+) channels in non-CAD versus CAD, resulting in an altered capacity for vasodilation during disease...
February 17, 2017: Circulation Research
https://www.readbyqxmd.com/read/27846269/correction-dissecting-the-effects-of-ischemia-and-reperfusion-on-the-coronary-microcirculation-in-a-rat-model-of-acute-myocardial-infarction
#11
Maurits R Hollander, Guus A de Waard, Lara S F Konijnenberg, Rosalie M E Meijer-van Putten, Charissa E van den Brom, Nanne Paauw, Helga E de Vries, Peter M van de Ven, Jurjan Aman, Geerten P Van Nieuw Amerongen, Peter L Hordijk, Hans W M Niessen, Anton J G Horrevoets, Niels Van Royen
[This corrects the article DOI: 10.1371/journal.pone.0157233.].
2016: PloS One
https://www.readbyqxmd.com/read/27753880/ish-ada-01-critical-role-of-telomerase-in-regulating-cerebral-vascular-function-and-redox-environment
#12
Karima Ait-Aissa, Joseph Hockenberry, David Gutterman, Aron Geurts, Andreas Beyer
OBJECTIVE: Flow mediated dilation (FMD) is the most physiological relevant form of endothelial-mediated vasodilation. Our laboratory has previously shown that telomerase, a ribo-nucleoprotein that counteracts telomere shortening, has a protective effect on endothelial function under conditions of oxidative stress in the human microcirculation. In the presence of coronary artery disease, decreased telomerase activity contributes to a shift in the mediator of FMD from atheroprotective nitric oxide (NO) to pro-inflammatory and atherogenic hydrogen peroxide (H2O2)...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27716639/depth-resolved-3d-visualization-of-coronary-microvasculature-with-optical-microangiography
#13
Wan Qin, Meredith A Roberts, Xiaoli Qi, Charles E Murry, Ying Zheng, Ruikang K Wang
In this study, we propose a novel implementation of optical coherence tomography-based angiography combined with ex vivo perfusion of fixed hearts to visualize coronary microvascular structure and function. The extracorporeal perfusion of Intralipid solution allows depth-resolved angiographic imaging, control of perfusion pressure, and high-resolution optical microangiography. The imaging technique offers new opportunities for microcirculation research in the heart, which has been challenging due to motion artifacts and the lack of independent control of pressure and flow...
November 7, 2016: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/27693512/cutaneous-microvascular-reactivity-and-aortic-elasticity-in-coronary-artery-disease-comparison-of-the-laser-doppler-flowmetry-and-echocardiography
#14
Edip Güvenç Çekiç, Özcan Başaran, Nesrin Filiz Başaran, Onur Elmas, Volkan Doğan, Gurbet Özge Mert, Kadir Uğur Mert, Ibrahim Altun, Fatih Akın, Murat Biteker
BACKGROUND AND AIM: Decreased vascular reactivity in atherosclerosis was previously shown. In our study, it was aimed to demonstrate the decreased vascular functions in both microvascular and macrovascular tissues and to estimate any correlation between them. METHODS: Twenty-five control outpatients with no coronary artery disease (CAD) history and 26 outpatients with CAD history were enrolled in the study. Local cutaneous post-occlusive reactive hyperemia (PORH) responses after three minutes of brachial occlusion with a pneumatic cuff were recorded noninvasively by a Perimed Periflux 5010 laser Doppler flow system...
January 2017: Microvascular Research
https://www.readbyqxmd.com/read/27666136/microvascular-reactivity-and-endothelial-glycocalyx-degradation-when-administering-hydroxyethyl-starch-or-crystalloid-during-off-pump-coronary-artery-bypass-graft-surgery-a-randomised-trial
#15
T K Kim, K Nam, Y J Cho, J J Min, Y J Hong, K U Park, D M Hong, Y Jeon
The infusion of fluids to patients may affect tissue microcirculation and the endothelial glycocalyx. However, the effects of hydroxyethyl starch and crystalloid on endothelial glycocalyx degradation and microvascular reactivity have not been evaluated in detail. We hypothesised that hydroxyethyl starch may cause less endothelial glycocalyx degradation and better microvascular reactivity than that caused by crystalloid. We randomly allocated 120 patients undergoing off-pump coronary artery bypass graft surgery to receive up to 20 ml...
September 26, 2016: Anaesthesia
https://www.readbyqxmd.com/read/27643173/ish-ada-01-critical-role-of-telomerase-in-regulating-cerebral-vascular-function-and-redox-environment
#16
Karima Ait-Aissa, Joseph Hockenberry, David Gutterman, Aron Geurts, Andreas Beyer
OBJECTIVE: Flow mediated dilation (FMD) is the most physiological relevant form of endothelial-mediated vasodilation. Our laboratory has previously shown that telomerase, a ribo-nucleoprotein that counteracts telomere shortening, has a protective effect on endothelial function under conditions of oxidative stress in the human microcirculation. In the presence of coronary artery disease, decreased telomerase activity contributes to a shift in the mediator of FMD from atheroprotective nitric oxide (NO) to pro-inflammatory and atherogenic hydrogen peroxide (H2O2)...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27600462/relation-between-neutrophil-to-lymphocyte-ratio-and-index-of-microcirculatory-resistance-in-patients-with-st-segment-elevation-myocardial-infarction-undergoing-primary-percutaneous-coronary-intervention
#17
Man-Jong Lee, Sang-Don Park, Sung Woo Kwon, Seong-Ill Woo, Myung-Dong Lee, Sung-Hee Shin, Dae-Hyeok Kim, Jun Kwan, Keum-Soo Park
The neutrophil-to-lymphocyte ratio (NLR) has been proved as a reliable inflammatory marker for the atherosclerotic process and as a predictor for clinical outcomes in patients with various cardiovascular diseases. A recent study reported that elevated NLR is associated with impaired myocardial perfusion in patients with ST-segment elevation myocardial infarction (STEMI). We investigated whether NLR is associated with coronary microcirculation as assessed by the index of microcirculatory resistance (IMR) in patients with STEMI who had undergone primary percutaneous coronary intervention (PCI)...
November 1, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/27574736/tanshinol-suppresses-cardiac-allograft-rejection-in-a-murine-model
#18
Chuanjian Lu, Yu-Qun Zeng, Huazhen Liu, Qingfeng Xie, Shengmei Xu, Kangsheng Tu, Changwei Dou, Zhenhua Dai
BACKGROUND: Achieving long-term cardiac allograft survival without continuous immunosuppression is highly desired in organ transplantation. Studies have shown that Salvia miltiorrhiza, an herb also known as danshen, improves microcirculation and is highly effective in treating coronary heart disease. Our objective is to determine whether tanshinol, an ingredient of danshen, improves cardiac allograft survival. METHODS: Fully vascularized heterotopic heart transplantation was performed using BALB/c mice as donors and C57BL/6 mice as recipients, which were then treated with tanshinol and rapamycin...
July 27, 2016: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/27542781/novel-monorail-infusion-catheter-for-volumetric-coronary-blood-flow-measurement-in-humans-in-vitro-validation
#19
Marcel van 't Veer, Julien Adjedj, Inge Wijnbergen, Gabor G Tóth, Marcel C M Rutten, Emanuele Barbato, Lokien X van Nunen, Nico H J Pijls, Bernard De Bruyne
AIMS: The aim of this study is to validate a novel monorail infusion catheter for thermodilution-based quantitative coronary flow measurements. METHODS AND RESULTS: Based on the principles of thermodilution, volumetric coronary flow can be determined from the flow rate of a continuous saline infusion, the temperature of saline when it enters the coronary artery, and the temperature of the blood mixed with the saline in the distal part of the coronary artery. In an in vitro set-up of the systemic and coronary circulation at body temperature, coronary flow values were varied from 50-300 ml/min in steps of 50 ml/min...
August 20, 2016: EuroIntervention
https://www.readbyqxmd.com/read/27541650/is-activation-in-inflammatory-bowel-diseases-associated-with-further-impairment-of-coronary-microcirculation
#20
Zuhal Caliskan, Nursen Keles, Huseyin Savas Gokturk, Kamil Ozdil, Feyza Aksu, Oguzhan Ozturk, Resul Kahraman, Osman Kostek, Ahmet S Tekin, Gulsum Teke Ozgur, Mustafa Caliskan
BACKGROUND: Inflammatory bowel disease [IBD] includes a number of chronic relapsing diseases. In IBD intestinal microvascular endothelial cells are damaged by an abnormal immune response. Several studies have shown that IBD may cause increment in risk of developing atherosclerosis. IBD in activation was related to enhanced risks of worse cardiovascular [CV] outcome, on the other hand no risk increment was seen in remission comparing to control group in those studies. Coronary Flow Reserve [CFR] reflects coronary microvascular circulation...
November 15, 2016: International Journal of Cardiology
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