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Coronary microcirculation

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https://www.readbyqxmd.com/read/29344840/design-and-rationale-for-comparison-between-ticagrelor-and-clopidogrel-on-microcirculation-in-patients-with-acute-coronary-syndrome-undergoing-percutaneous-coronary-intervention-pleio-trial
#1
Kyungil Park, Young-Rak Cho, Jong-Sung Park, Tae-Ho Park, Moo-Hyun Kim, Young-Dae Kim
It has been previously demonstrated that ticagrelor can reduce mortality compared to clopidogrel in acute coronary syndrome (ACS) patients. However, the mechanism for this mortality reduction remains uncertain. The objective of the present study is to assess the impact of chronic ticagrelor treatment on microvascular circulation. A total of 120 participants aged 20-85 years with clinical diagnosis of ACS will be randomized in a 1:1 fashion to the following two groups: ticagrelor 90 mg twice daily; clopidogrel 75 mg once daily...
January 17, 2018: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/29339697/the-value-of-real-time-myocardial-contrast-echocardiography-for-detecting-coronary-microcirculation-function-in-coronary-artery-disease-patients
#2
Lulu Sun, Zilong Wang, Tongda Xu, Defeng Pan, Li Liang, Ji Hao, Xiaoping Wang, Dongye Li
OBJECTIVE: The aim of this study was to evaluate the value of real-time myocardial contrast echocardiography (RT-MCE) for detecting coronary microcirculation (CM) function in coronary artery disease (CAD) patients. METHODS: Sixty-five consecutive patients were divided into CAD (n=52) and no-CAD (n=13) groups using coronary angiography (CAG). All patients underwent RT-MCE at rest and CAG within 1 week after RT-MCE. The ventricular segments in CAD patients were divided semi-quantitatively into ischemic and non-ischemic myocardial groups based on RT-MCE images...
January 2018: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/29327562/development-of-a-porcine-beating-heart-model-of-self-myocardial-retroperfusion-evaluation-of-hemodynamic-and-cardiac-responses-to-ischemia-and-clinical-applications
#3
Daniel Grandmougin, Jean-Mathieu Casse, Antoine Chalon, Yun Luo, Aude Falanga, Vanessa Marie, Fréderique Groubatch-Joineau, Brice Mourer, Marie Grandmougin, David Grandmougin, Guillaume Gauchotte, Juan-Pablo Maureira, Nguyen Tran
BACKGROUND: Retrograde perfusion into the coronary sinus is used to deliver cardioplegia. We developed an in-vivo porcine beating-heart model of self-myocardial retroperfusion (SMR) using the venous route to supply myocardial oxygenation and sought to assess hemodynamic and cardiac responses triggered by SMR before and after a prolonged occlusion of the LAD. METHODS: A bypass-line between the ascending aorta and the coronary sinus was made to perform a selective retrograde perfusion of the great cardiac vein with oxygenated blood (SMR)...
January 9, 2018: Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/29312775/case-report-improvement-of-cardiac-remodeling-with-shock-wave-therapy-of-a-patient-with-ischemic-cardiomyopathy
#4
Yingnan Bai, Xiaoyan Wang, Xin Deng, Hongyi Wu, Abdel Hamid Fathy, Yan Xi, Yunzeng Zou, Jie Cui, Junbo Ge
Percutaneous coronary intervention (PCI) and coronary-artery bypass grafting (CABG) are two major preferred reperfusion strategies to restore the ischemic-related artery patency, but PCI and CABG do not necessarily guarantee the recovery of post-procedure left ventricular (LV) dysfunction and release of symptoms. Moreover, there is no definitive effective way to enhance microcirculations. Theoretically, shock wave therapy (SWT) is an option. We report here a case of patient who received SWT. The patient's medical history was characterized by chest pain for 20 years, having received CABG 13 years ago...
December 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29258572/effects-of-four-antiplatelet-statin-combined-strategies-on-immune-and-inflammatory-responses-in-patients-with-acute-myocardial-infarction-undergoing-pharmacoinvasive-strategy-design-and-rationale-of-the-b-and-t-types-of-lymphocytes-evaluation-in-acute-myocardial
#5
Francisco A H Fonseca, Maria Cristina Izar, Ieda M L Maugeri, Otavio Berwanger, Lucas P Damiani, Ibraim M Pinto, Gilberto Szarf, Carolina N França, Henrique T Bianco, Flavio T Moreira, Adriano Caixeta, Claudia M R Alves, Aline Soriano Lopes, Aline Klassen, Marina F M Tavares, Henrique A Fonseca, Antonio C C Carvalho
BACKGROUND: Early reperfusion of the occluded coronary artery during acute myocardial infarction is considered crucial for reduction of infarcted mass and recovery of ventricular function. Effective microcirculation and the balance between protective and harmful lymphocytes may have roles in reperfusion injury and may affect final ventricular remodeling. METHODS/DESIGN: BATTLE-AMI is an open-label, randomized trial comparing the effects of four therapeutic strategies (rosuvastatin/ticagrelor, rosuvastatin/clopidogrel, simvastatin plus ezetimibe/ticagrelor, or simvastatin plus ezetimibe/clopidogrel) on infarcted mass and left ventricular ejection fraction (LVEF) (blinded endpoints) in patients with ST-segment elevation myocardial infarction submitted to fibrinolytic therapy before coronary angiogram (pharmacoinvasive strategy)...
December 19, 2017: Trials
https://www.readbyqxmd.com/read/29232032/erosive-pustular-dermatosis-of-the-scalp-reappraisal-of-an-underrecognized-entity
#6
REVIEW
Michael Wilk, Bettina G Zelger, Undine Hauser, Reinhard Höpfl, Bernhard Zelger
Erosive pustular dermatosis of the scalp (EPDS) is an inflammatory dermatosis of unknown etiology. Herein, we present a review of the disease and report our own clinical and histopathological experience in eleven patients. EPDS tends to spontaneously affect bald areas of the scalp in elderly individuals. A history of previous surgery at the same site - as observed in four of our patients - is common. Coronary artery disease, cerebrovascular insult, arterial hypertension, diabetes mellitus, and severe cases of cancer were frequent comorbidities...
December 12, 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/29228159/patients-with-acute-myocardial-infarction-and-non-obstructive-coronary-arteries-safety-and-prognostic-relevance-of-invasive-coronary-provocative-tests
#7
Rocco A Montone, Giampaolo Niccoli, Francesco Fracassi, Michele Russo, Filippo Gurgoglione, Giulia Cammà, Gaetano A Lanza, Filippo Crea
Aims: Functional alterations of epicardial coronary arteries or coronary microcirculation represent a frequent cause of myocardial infarction and non-obstructive coronary arteries (MINOCA). We aimed at assessing the prognostic value of intracoronary provocative tests in patients presenting with MINOCA and in which other causes of MINOCA have been excluded. Methods and results: We prospectively evaluated patients with a diagnosis of MINOCA, excluding patients with aetiologies other than suspected coronary vasomotor abnormalities...
December 8, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29198139/evaluation-of-the-coronary-flow-by-the-coronary-clearance-time-in-patients-with-cardiac-syndrome-x
#8
Erkan Yildirim, Uygar Cagdas Yuksel, Murat Celik, Baris Bugan, Mutlu Gungor, Yalcin Gokoglan, Mustafa Koklu, Suat Gormel, Salim Yasar, Cem Barcin
Objective The vessels involved in the microcirculation are too small to be visualized by conventional angiography and no tools are currently available that can directly evaluate the coronary microcirculation. This study evaluated the coronary clearance frame count (CCFC) in patients with cardiac syndrome X (CSX). Methods The retrospective study enrolled patients with angina, who had a positive nuclear imaging test and normal coronary angiography; and a control group consisting of patients who underwent an angiogram to exclude coronary artery disease...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/29192067/effect-of-myostatin-deletion-on-cardiac-and-microvascular-function
#9
Joshua T Butcher, M Irfan Ali, Merry W Ma, Cameron G McCarthy, Bianca N Islam, Lauren G Fox, James D Mintz, Sebastian Larion, David J Fulton, David W Stepp
The objective of this study is to test the hypothesis that increased muscle mass has positive effects on cardiovascular function. Specifically, we tested the hypothesis that increases in lean body mass caused by deletion of myostatin improves cardiac performance and vascular function. Echocardiography was used to quantify left ventricular function at baseline and after acute administration of propranolol and isoproterenol to assess β-adrenergic reactivity. Additionally, resistance vessels in several beds were removed, cannulated, pressurized to 60 mmHg and reactivity to vasoactive stimuli was assessed...
December 2017: Physiological Reports
https://www.readbyqxmd.com/read/29191384/the-effect-of-bioresorbable-vascular-scaffold-implantation-on-distal-coronary-endothelial-function-in-dyslipidemic-swine-with-and-without-diabetes
#10
Mieke van den Heuvel, Oana Sorop, Nienke S van Ditzhuijzen, René de Vries, Richard W B van Duin, Ilona Krabbendam-Peters, Janine E van Loon, Moniek P de Maat, Heleen M van Beusekom, Wim J van der Giessen, A H Jan Danser, Dirk J Duncker
BACKGROUND: We studied the effect of bioresorbable vascular scaffold (BVS) implantation on distal coronary endothelial function, in swine on a high fat diet without (HFD) or with diabetes (DM+HFD). METHODS: Five DM+HFD and five HFD swine underwent BVS implantation on top of coronary plaques, and were studied six months later. Conduit artery segments >5mm proximal and distal to the scaffold and corresponding control segments of non-scaffolded coronary arteries, as well as segments of small arteries within the flow-territories of scaffolded and non-scaffolded arteries were harvested for in vitro vasoreactivity studies...
November 20, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/29189827/-coronary-microvascular-dysfunction-past-present-and-future-of-an-evolving-disease
#11
Vincenzo Sucato, Salvatore Evola, Giuseppina Novo, Nicolò Bellante, Giuseppe Andolina, Salvatore Novo
Coronary atherosclerosis is the main cause of myocardial ischemia. Nevertheless 10-30% of patients with angina has angiographically normal coronary arteries. In the last 30 years, several studies showed that in these patients the symptoms can be caused by dysfunction of the coronary microcirculation. Coronary microvascular dysfunction (CMVD) occurring in patients affected by specific cardiac or systemic diseases may be due to mechanisms of the underlying disease. On the other hand, in several patients affected by angina with angiographically normal coronary arteries, there is no specific disease, and CMVD only is responsible for the clinical picture...
December 2017: Giornale Italiano di Cardiologia
https://www.readbyqxmd.com/read/29178250/sublingual-functional-capillary-rarefaction-in-chronic-heart-failure
#12
Patricia P Wadowski, Martin Hülsmann, Christian Schörgenhofer, Irene M Lang, Raphael Wurm, Thomas Gremmel, Renate Koppensteiner, Barbara Steinlechner, Michael Schwameis, Bernd Jilma
BACKGROUND AND OBJECTIVE: Microcirculatory changes contribute to clinical symptoms and disease progression in chronic heart failure (CHF). A depression of coronary flow reserve is associated with a lower myocardial capillary density in biopsies. We hypothesized that changes in cardiac microcirculation might also be reflected by a systemic reduction of capillaries and visualized by sublingual videomicroscopy. The aim was to study in vivo capillary density and glycocalyx dimensions in patients with CHF vs...
November 25, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29147131/transcriptional-activity-of-tumor-necrosis-factor-alpha-gene-in-peripheral-blood-mononuclear-cells-in-patients-with-coronary-slow-flow
#13
Yousef Rasmi, Morteza Bagheri, Sanaz Faramarz-Gaznagh, Mohadeseh Nemati, Mohammad Hasan Khadem-Ansari, Ehsan Saboory, Mir Hossein Seyed-Mohamadzad, Alireza Shirpoor
BACKGROUND: Coronary slow flow (CSF), an angiographic phenomenon that is characterized by a delayed coronary blood flow in the absence of obstructive coronary artery stenosis, is known as a disorder of the coronary microcirculation. Inflammation has an important role in the vascular hemostasis and endothelial dysfunction especially regarding monocyte adhesion and infiltration. Pro-inflammatory cytokines released by inflammatory cells result in endothelial cell dysfunction and cardiovascular diseases...
July 2017: ARYA Atherosclerosis
https://www.readbyqxmd.com/read/29108788/peri-procedural-st-segment-resolution-during-primary-percutaneous-coronary-intervention-ppci-for-acute-myocardial-infarction-predictors-and-clinical-consequences
#14
Grigoris V Karamasis, Paul Russhard, Firas Al Janabi, Michael Parker, John R Davies, Thomas R Keeble, Gerald J Clesham
OBJECTIVE: ECG ST segment resolution (STR) has been used to assess myocardial perfusion in STEMI patients undergoing PPCI. However, in most of the studies ECGs recorded at different time points after the actual procedure have been used, limiting the options of therapeutic interventions while the patient is still in the catheterisation laboratory. The aim of this study was to investigate the presence and clinical consequences of intra-procedural STR during PPCI. METHODS: We analysed 12 lead ECGs recorded at the onset and the end of the PPCI procedure, measuring STR in the lead with maximum ST elevation on the initial recording...
October 5, 2017: Journal of Electrocardiology
https://www.readbyqxmd.com/read/29105473/-effect-of-electroacupuncture-at-neiguan-pc-6-on-skin-microcirculation-blood-perfusion-volume-of-heart-related-acupoints-and-heart-irrelevant-acupoints-in-myocardial-ischemia-rats
#15
Jian Dai, Bo Ji, Ya-Wen Lu, Guo-Zhen Zhao, Dan Wang, Ming-Na Yan, Hong-Xin Bai, Xiao-Min Sun, Min You, Jiao-Juan Wu, Meng-Wei Guo, Zhi-Gang Li, Kai Cheng
OBJECTIVE: To observe the effect of low-frequency or high-frequency electroacupuncture (EA) stimulation of "Neiguan" (PC 6) on changes of skin blood perfusion volume of heart-related and heart-irrelevant acupoints in rats with normal or ischemic myocardium. METHODS: Wistar rats were randomly divided into the control, sham-operation, model, low-frequency EA and high-frequency EA groups (n=8 in each group). The myocardial ischemic (MI) model was established by occlusion of the anterior descending branch of the left coronary artery...
October 25, 2017: Zhen Ci Yan Jiu, Acupuncture Research
https://www.readbyqxmd.com/read/29096829/ldl-apheresis-improves-coronary-flow-reserve-on-the-left-anterior-descending-artery-in-patients-with-familial-hypercholesterolemia-and-chronic-ischemic-heart-disease
#16
Tiziana Sampietro, Francesco Sbrana, Emilio Maria Pasanisi, Federico Bigazzi, Christina Petersen, Michele Coceani, Beatrice Dal Pino, Andrea Ripoli, Mascia Pianelli, Roberta Luciani
BACKGROUND: LDL apheresis (LA) influences the microcirculation, endothelial function and cardiovascular homeostasis. The aim of our study was to analyze temporal variations of coronary flow reserve (CFR) on the left anterior descending artery, obtained during dipyridamole stress echocardiography (DSE), in patients with severe familial hypercholesterolemia on LA (LA group) or not (not LA group) and ischemic heart disease (IHD). METHODS: The LA group consisted in 10 patients (mean age 65 ± 7 years, male 70%) with Familial Hypercholesterolemia and chronic IHD on maximally tolerated lipid lowering therapy and chronic LA treatment (median 7 years, interquartile range 6-14 years)...
November 2017: Atherosclerosis. Supplements
https://www.readbyqxmd.com/read/29095792/important-role-of-endothelial-caveolin-1-in-the-protective-role-of-edh-against-no-mediated-nitrative-stress-in-microcirculation-in-mice
#17
Hiroki Saito, Shigeo Godo, Saori Sato, Akiyo Ito, Yosuke Ikumi, Shuhei Tanaka, Tomoaki Ida, Shigemoto Fujii, Takaaki Akaike, Hiroaki Shimokawa
AIMS: Nitric oxide (NO) and endothelium-dependent hyperpolarization (EDH) play important roles in maintaining cardiovascular homeostasis. We have previously demonstrated that endothelial NO synthase (eNOS) plays diverse roles depending on vessel size, as a NO generating system in conduit arteries and an EDH-mediated system in resistance arteries, for which caveolin-1(Cav-1) is involved. However, the physiological role of endothelial Cav-1 in microvessels remains to be elucidated. METHODS AND RESULTS: We newly generated endothelium-specific Cav-1-knockout (eCav-1-KO) mice...
October 27, 2017: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/29073930/functional-evaluation-of-sublingual-microcirculation-indicates-successful-weaning-from-va-ecmo-in-cardiogenic-shock
#18
Sakir Akin, Dinis Dos Reis Miranda, Kadir Caliskan, Osama I Soliman, Goksel Guven, Ard Struijs, Robert J van Thiel, Lucia S Jewbali, Alexandre Lima, Diederik Gommers, Felix Zijlstra, Can Ince
BACKGROUND: Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is increasingly adopted for the treatment of cardiogenic shock (CS). However, a marker of successful weaning remains largely unknown. Our hypothesis was that successful weaning is associated with sustained microcirculatory function during ECMO flow reduction. Therefore, we sought to test the usefulness of microcirculatory imaging in the same sublingual spot, using incident dark field (IDF) imaging in assessing successful weaning from VA-ECMO and compare IDF imaging with echocardiographic parameters...
October 26, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29059651/-the-features-of-a-functional-state-of-the-coronary-circulation-in-women-smokers-with-non-st-elevation-acute-coronary-syndrome
#19
Тетяна М Соломенчук, Артем О Бедзай, Василь В Процько
INTRODUCTION: Acute coronary syndrome is one of the most adverse prognostic clinical forms of ischemic heart disease. In recent years, attention of researchers and cardiologists practical attract female patients due to a substantial increase in the prevalence including acute coronary syndrome, differences in the causes and features of its course. Women often diagnosed myocardial infarction without ST elevation and nonobstructive coronary heart disease associated with coronary spasm or stratification of coronary artery...
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29051126/resistance-to-flow-in-the-coronary-microcirculation-we-can-measure-it-but-what-does-it-mean
#20
Amrit Bajrangee, Damien Collison, Keith G Oldroyd
No abstract text is available yet for this article.
October 20, 2017: EuroIntervention
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