keyword
https://read.qxmd.com/read/38514060/shenmai-injection-alleviates-myocardial-ferroptosis-via-activating-the-akt1-mtor-pathway-in-rats-with-acute-myocardial-infarction
#21
JOURNAL ARTICLE
Ming Lu, Yeying Zhang, Xuhui Ma, Mingqiu Cen, Shidong Lin, Xiaolu Qian, Jia Yu, Xiaoying Huang, Zhuxiu Jiang
OBJECTIVE: Acute myocardial infarction (AMI) poses a serious burden on public health. Shenmai Injection (SMI) has been reported to have a cardioprotective effect and is used clinically attributed to its targeting of ferroptosis. This study aims to explore the underlying mechanisms of SMI in treating AMI through the application of network pharmacology analysis. METHODS: This study utilized network pharmacology to identify the bioactive ingredients and potential targets of SMI in treating AMI...
January 2024: Annals of Clinical and Laboratory Science
https://read.qxmd.com/read/38513595/maximakinin-reversed-h-2-o-2-induced-oxidative-damage-in-rat-cardiac-h9c2-cells-through-ampk-akt-and-ampk-erk1-2-signaling-pathways
#22
JOURNAL ARTICLE
Yang Yu, Fan-Fan Su, Cheng Xu
Maximakinin (MK), a homolog of bradykinin (BK), is extracted from skin venom of the Chinese toad Bombina maxima. Although MK has a good antihypertensive effect, its effect on myocardial cells is unclear. This study investigates the protective effect of MK on hydrogen peroxide (H2 O2 )-induced oxidative damage in rat cardiac H9c2 cells and explores its mechanism of action. A 3-(4,5-Dimethyl-2-Thiazolyl)-2,5-Diphenyl Tetrazolium Bromide (MTT) assay was selected to detect the effect of MK on H9c2 cell viability, while flow cytometry was used to investigate the influence of MK and H2 O2 on intracellular reactive oxygen species (ROS) levels...
March 20, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38511210/mechanisms-of-coronary-sinus-reducer-for-treatment-of-myocardial-ischemia-in-silico-study
#23
JOURNAL ARTICLE
Haifeng Wang, Lei Fan, Jenny S Choy, Ghassan S Kassab, Lik Chuan Lee
The coronary sinus reducer (CSR) is an emerging medical device for treating patients with refractory angina, often associated with myocardial ischemia. Patients implanted with CSR have shown positive outcomes, but the underlying mechanisms are unclear. This study sought to understand the mechanisms of CSR by investigating its effects on coronary microcirculation hemodynamics that may help explain the therapy's efficacy. We applied a validated computer model of the coronary microcirculation to investigate how CSR affects hemodynamics under different degrees of coronary artery stenosis...
March 21, 2024: Journal of Applied Physiology
https://read.qxmd.com/read/38507848/cumulative-epinephrine-dose-during-cardiac-arrest-and-neurologic-outcome-after-extracorporeal-cardiopulmonary-resuscitation
#24
JOURNAL ARTICLE
Samuel I Garcia, Troy G Seelhammer, Sahar A Saddoughi, Alexander S Finch, John G Park, Patrick M Wieruszewski
BACKGROUND: Epinephrine is recommended without an apparent ceiling dosage during cardiac arrest. However, excessive alpha- and beta-adrenergic stimulation may contribute to unnecessarily high aortic afterload, promote post-arrest myocardial dysfunction, and result in cerebral microvascular insufficiency in patients receiving extracorporeal cardiopulmonary resuscitation (ECPR). METHODS: This was a retrospective cohort study of adults (≥ 18 years) who received ECPR at large academic ECMO center from 2018 to 2022...
March 15, 2024: American Journal of Emergency Medicine
https://read.qxmd.com/read/38507311/emodin-ameliorates-myocardial-fibrosis-in-mice-by-inactivating-the-ros-pi3k-akt-mtor-axis
#25
JOURNAL ARTICLE
Wei Huang, Peiting Zhou, Xinyun Zou, Yunchuan Liu, Longfu Zhou, Yaolei Zhang
BACKGROUND: Emodin is a traditional medicine that has been shown to exert anti-inflammatory and anti-oxidative effects. Previous research has indicated that emodin can alleviate myocardial remodeling and inhibit myocardial hypertrophy and fibrosis. However, the mechanism by which emodin affects myocardial fibrosis (MF) has not yet been elucidated. METHODS: Fibroblasts were treated with ANGII, and a mouse model of MF was established by ligation of the left anterior descending coronary artery...
December 31, 2024: Clinical and Experimental Hypertension: CHE
https://read.qxmd.com/read/38505065/prognostic-implication-of-vasoactive-inotropic-score-in-adult-patients-with-cardiogenic-shock-on-veno-arterial-extracorporeal-membrane-oxygenation
#26
JOURNAL ARTICLE
Yao Hu, Liangshan Wang, Feng Yang, Xiaomeng Wang, Shuai Zhang, Xing Hao, Hong Wang, Xiaotong Hou
BACKGROUND: Vasopressors and inotropes are crucial in managing cardiogenic shock (CS) as they enhance microcirculation in patients. Numerous studies have demonstrated the adverse outcomes associated with excessive use of vasoactive drugs and the vasoactive drug scoring system has emerged as a valuable prognostic tool, particularly in pediatric patients. This study aimed to examine the prognostic significance of the Vasoactive Inotropic Score (VIS) in adult patients with CS receiving veno-arterial extracorporeal membrane oxygenation (VA-ECMO) treatment...
February 29, 2024: Journal of Thoracic Disease
https://read.qxmd.com/read/38502888/early-vs-delayed-mechanical-circulatory-support-in-patients-with-acute-myocardial-infarction-and-cardiogenic-shock
#27
JOURNAL ARTICLE
Kevin G Buda, Katarzyna Hryniewicz, Peter M Eckman, Mir B Basir, Jennifer A Cowger, Khaldoon Alaswad, Srini Mukundan, Yader Sandoval, Andrea Elliott, Emmanouil S Brilakis, Michael S Megaly
BACKGROUND: Despite increased temporary mechanical circulatory support (tMCS) utilization for acute myocardial infarction complicated by cardiogenic shock (AMI-CS), data regarding efficacy and optimal timing for tMCS support are limited. This study aimed to describe outcomes based on tMCS timing in AMI-CS and to identify predictors of 30-day mortality and readmission. METHODS: Patients with AMI-CS identified in the National Readmissions Database were grouped according to the use of tMCS and early (<24 hours) vs...
March 19, 2024: European Heart Journal. Acute Cardiovascular Care
https://read.qxmd.com/read/38499702/oxidation-reduction-imaging-of-myoglobin-reveals-two-phase-oxidation-in-the-reperfused-myocardium
#28
JOURNAL ARTICLE
Sally Badawi, Clémence Leboullenger, Matthieu Chourrout, Yves Gouriou, Alexandre Paccalet, Bruno Pillot, Lionel Augeul, Radu Bolbos, Antonino Bongiovani, Nathan Mewton, Thomas Bochaton, Michel Ovize, Meryem Tardivel, Mazen Kurdi, Emmanuelle Canet-Soulas, Claire Crola Da Silva, Gabriel Bidaux
Myocardial infarction (MI) is a serious acute cardiovascular syndrome that causes myocardial injury due to blood flow obstruction to a specific myocardial area. Under ischemic-reperfusion settings, a burst of reactive oxygen species is generated, leading to redox imbalance that could be attributed to several molecules, including myoglobin. Myoglobin is dynamic and exhibits various oxidation-reduction states that have been an early subject of attention in the food industry, specifically for meat consumers. However, rarely if ever have the myoglobin optical properties been used to measure the severity of MI...
March 18, 2024: Basic Research in Cardiology
https://read.qxmd.com/read/38494729/an-autopsy-case-of-fulminant-myocarditis-with-massive-left-ventricular-calcification
#29
JOURNAL ARTICLE
Satsuki Yagi-Nakajima, Masanobu Miura, Shun Sawada, Takahiro Funaki, Kumi Uchimura, Kai Susukita, Tsubasa Hatakeyama, Yuta Kagaya, Hiroki Saito, Kenjiro Sato, Masanori Kanazawa, Masateru Kondo, Hideaki Endo, Hiroshi Yaegashi, Akihiro Nakamura
Myocardial calcification in myocarditis is rare and may be linked to poor outcomes. We herein report a case of fulminant myocarditis with massive myocardial calcification and its pathological outcomes at autopsy. A 49-year-old man experienced chest pain and was diagnosed with acute myocarditis. His cardiac function did not recover despite mechanical circulatory support in combination with V-A extracorporeal membrane oxygenation and IMPELLA CP® . He eventually developed sepsis and gastrointestinal bleeding and died on day 27...
2024: Internal Medicine
https://read.qxmd.com/read/38492623/a-review-regarding-the-article-supervised-exercise-training-in-heart-failure-with-preserved-ejection-fraction-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#30
REVIEW
Ping Zhang, Yunfei Ling
Heart failure is a clinical syndrome with different etiologies and phenotypes. For all forms, supervised exercise training and individual physical activity are class IA recommendations in current guidelines. Over the past two decades it has become recognized that physical deconditioning may play a key role in the progression of symptoms and poor outcomes. A number of prior studies have assessed the ability of exercise training to improve functional capacity in patients with HF. Most of these previous studies showed positive effects of exercise training on exercise capacity, quality of life, and biomarkers and observed relatively few complications during training...
March 14, 2024: Current Problems in Cardiology
https://read.qxmd.com/read/38490981/plekhm2-deficiency-induces-impaired-mitochondrial-clearance-and-elevated-ros-levels-in-human-ipsc-derived-cardiomyocytes
#31
JOURNAL ARTICLE
Jianchao Zhang, Ying Peng, Wanrong Fu, Ruifei Wang, Jinhua Cao, Shuang Li, Xiaoxu Tian, Zhonggen Li, Chongpei Hua, Yafei Zhai, Yangyang Liu, Mengduan Liu, Jihong Sun, Xiaowei Li, Xiaoyan Zhao, Jianzeng Dong
Pleckstrin homology domain-containing family M member 2 (PLEKHM2) is an essential adaptor for lysosomal trafficking and its homozygous truncation have been reported to cause early onset dilated cardiomyopathy (DCM). However, the molecular mechanism of PLEKHM2 deficiency in DCM pathogenesis and progression is poorly understood. Here, we generated an in vitro model of PLEKHM2 knockout (KO) induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) to elucidate the potential pathogenic mechanism of PLEKHM2-deficient cardiomyopathy...
March 15, 2024: Cell Death Discovery
https://read.qxmd.com/read/38490254/temporary-extracorporeal-life-support-single-center-experience-with-a-new-concept
#32
JOURNAL ARTICLE
Gaik Nersesian, Daniel Lewin, Sascha Ott, Felix Schoenrath, Yuriy Hrytsyna, Christoph Starck, Frank Spillmann, Benjamin O'Brien, Volkmar Falk, Evgenij Potapov, Pia Lanmueller
OBJECTIVES: The combination of veno-arterial extracorporeal membrane oxygenation (va-ECMO) with a micro-axial flow pump (ECMELLA) is increasingly used for cardiogenic shock (CS) therapy. We report our experience with a novel single-artery access ECMELLA setup with either femoral (2.0) or jugular venous cannulation (2.1), respectively. METHODS: Data from 67 consecutive CS patients treated with ECMELLA 2.0 (n = 56) and 2.1 (n = 11) from 12/2020 and 12/2022 in a tertiary cardiac center were retrospectively analyzed...
March 15, 2024: Interdiscip Cardiovasc Thorac Surg
https://read.qxmd.com/read/38489253/upregulation-of-nrf2-in-myocardial-infarction-and-ischemia-reperfusion-injury-of-the-heart
#33
JOURNAL ARTICLE
Sahar Zuberi, Hira Rafi, Azhar Hussain, Satwat Hashmi
Myocardial infarction (MI) is a leading cause of morbidity and mortality in the world and is characterized by ischemic necrosis of an area of the myocardium permanently devoid of blood supply. During reperfusion, reactive oxygen species are released and this causes further insult to the myocardium, resulting in ischemia-reperfusion (IR) injury. Since Nrf2 is a key regulator of redox balance, it is essential to determine its contribution to these two disease processes. Conventionally Nrf2 levels have been shown to rise immediately after ischemia and reperfusion but its contribution to disease process a week after the injury remains uncertain...
2024: PloS One
https://read.qxmd.com/read/38485621/the-ecls-shock-trial-don-t-draw-hasty-conclusions-the-devil-is-in-the-details%C3%A2
#34
EDITORIAL
Guillaume Lebreton, Pascal Leprince
No abstract text is available yet for this article.
March 5, 2024: Archives of Cardiovascular Diseases
https://read.qxmd.com/read/38484033/circadian-clock-and-hypoxia
#35
REVIEW
Francesca Sartor, Borja Ferrero-Bordera, Jeffrey Haspel, Markus Sperandio, Paul M Holloway, Martha Merrow
The timing of life on Earth is remarkable: between individuals of the same species, a highly similar temporal pattern is observed, with shared periods of activity and inactivity each day. At the individual level, this means that over the course of a single day, a person alternates between two states. They are either upright, active, and communicative or they lie down in a state of (un)consciousness called sleep where even the characteristic of neuronal signals in the brain shows distinctive properties. The circadian clock governs both of these time stamps-activity and (apparent) inactivity-making them come and go consistently at the same approximate time each day...
March 15, 2024: Circulation Research
https://read.qxmd.com/read/38478872/mitochondrial-transplantation-combined-with-coenzyme-q-10-induces-cardioprotection-and-mitochondrial-improvement-in-aged-male-rats-with-reperfusion-injury
#36
JOURNAL ARTICLE
Soleyman Bafadam, Behnaz Mokhtari, Manoucheher Seyedi Vafaee, Zohreh Zavvari Oscuyi, Samira Nemati, Reza Badalzadeh
Ischaemic heart diseases (IHD) are among the major causes of mortality in the elderly population. Although timely reperfusion is a common treatment for IHD, it causes additional damage to the ischaemic myocardium known as ischaemia-reperfusion (IR) injury. Considering the importance of preventing reperfusion injuries, we aimed to examine the combination effect of mitochondrial transplantation (MT) and coenzyme Q10 (CoQ10 ) in myocardial IR injury of aged male rats. Seventy-two aged male Wistar rats were randomly divided into six groups: Sham, IR, CoQ10 , MT, combination therapy (MT + CoQ10 ) and vehicle...
March 13, 2024: Experimental Physiology
https://read.qxmd.com/read/38471822/research-progress-and-clinical-value-of-subendocardial-viability-ratio
#37
REVIEW
Haotai Xie, Lan Gao, Fangfang Fan, Yanjun Gong, Yan Zhang
Cardiovascular disease remains the leading cause of morbidity and mortality worldwide, with ischemic heart disease being a major contributor, either through coronary atherosclerotic plaque-related major vascular disease or coronary microvascular dysfunction. Obstruction of coronary blood flow impairs myocardial perfusion, which may lead to acute myocardial infarction in severe cases. The subendocardial viability ratio, also known as the Buckberg index, is a valuable tool for evaluation of myocardial perfusion because it reflects the balance between myocardial oxygen supply and oxygen demand...
March 12, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38471248/bleeding-complications-coagulation-disorders-and-their-management-in-acute-myocardial-infarction-related-cardiogenic-shock-rescued-by-veno-arterial-ecmo-a-retrospective-cohort-study
#38
JOURNAL ARTICLE
Paul Masi, Ségolène Gendreau, Quentin Moyon, Maxence Leguyader, Guillaume Lebreton, Jacques Ropers, Laurence Dangers, Samuel Sitruk, Nicolas Bréchot, Marc Pineton de Chambrun, Juliette Chommeloux, Matthieu Schmidt, Charles Edouard Luyt, Pascal Leprince, Alain Combes, Corinne Frere, Guillaume Hékimian
PURPOSE: Management of dual antiplatelet therapy (DAPT) in patients on venoarterial-extracorporeal membrane (VA-ECMO) after acute myocardial infarction (AMI) is challenging. Our objective was to describe the frequency, management and outcomes of severe bleeding complications and determine their occurrence risk factors. MATERIAL AND METHODS: We conducted a retrospective observational cohort study including post-AMI cardiogenic shock patients requiring VA-ECMO. Severe bleeding was defined based on the Bleeding Academic Research Consortium classification...
March 11, 2024: Journal of Critical Care
https://read.qxmd.com/read/38471194/postoperative-haemoglobin-and-anaemia-associated-ischaemic-events-after-major-noncardiac-surgery-a-sex-stratified-cohort-study
#39
JOURNAL ARTICLE
Bing-Cheng Zhao, Yi-Shan Xie, Wen-Chi Luo, Shao-Hui Lei, Jia-Ming Liu, Xiao Yang, Ye-Hong Dong, Wei-Feng Liu, Ke-Xuan Liu
STUDY OBJECTIVE: To determine the sex-specific associations between postoperative haemoglobin and mortality or complications reflecting ischaemia or inadequate oxygen supply after major noncardiac surgery. DESIGN: A retrospective cohort study with prospective validation. SETTING: A large university hospital health system in China. PATIENTS: Men and women undergoing elective major noncardiac surgery. INTERVENTIONS AND MEASUREMENTS: The primary exposure was nadir haemoglobin within 48 h after surgery...
March 11, 2024: Journal of Clinical Anesthesia
https://read.qxmd.com/read/38467329/scanning-the-imaging-horizon-for-hypertrophic-cardiomyopathy
#40
REVIEW
Andrew M Crean
This paper discusses some of the recent advances in the use of noninvasive imaging applied to patients with hypertrophic cardiomyopathy. Echocardiography and cardiac CT are briefly discussed with respect to their power to detect apical aneurysmal disease. Echo phenotype-genotype correlations and the ability of echo to characterize myocardial work are reviewed. Positron emission tomography (PET) is reviewed in the context of ischaemia imaging and also the use of a new tracer which may allow for recognition of early activation of the fibrosis pathway...
March 9, 2024: Canadian Journal of Cardiology
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