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https://www.readbyqxmd.com/read/28643395/catalase-ameliorates-diabetes-induced-cardiac-injury-through-reduced-p65-rela-mediated-transcription-of-becn1
#1
Xu Wang, Youli Tao, Yewei Huang, Kungao Zhan, Mei Xue, Ying Wang, Dandan Ruan, Yangzhi Liang, Xiaozhong Huang, Jianjun Lin, Zhiwei Chen, Lingchun Lv, Santie Li, Gen Chen, Yang Wang, Ruijie Chen, Weitao Cong, Litai Jin
Catalase is an antioxidative enzyme that converts hydrogen peroxide (H2 O2 ) produced by superoxide dismutase from highly reactive superoxide (O2(-) ) to water and oxygen molecules. Although recent findings demonstrate that catalase, autophagy and the nuclear factor κB (NF-κB) signalling pathway are centrally involved in diabetic cardiomyopathy (DCM), the interplay between the three has not been fully characterized. Thus, the mechanism responsible for catalase-mediated protection against heart injury in diabetic mice was investigated in this study, as well as the role of NF-κB-p65 in the regulation of autophagic flux was investigated in this study...
June 23, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28642302/residual-erythropoiesis-protects-against-myocardial-hemosiderosis-in-transfusion-dependent-thalassemia-by-lowering-labile-plasma-iron-via-transient-generation-of-apotransferrin
#2
Maciej W Garbowski, Patricia Evans, Evangelia Vlachodimitropoulou, Robert Hider, John B Porter
Cardiosiderosis is a leading cause of mortality in transfusion-dependent thalassemias. Plasma non-transferrin-bound iron and its redox-active component, labile plasma iron, are key sources of iron loading in cardiosiderosis. Risk factors were identified in 73 patients with or without cardiosiderosis. Soluble transferrin receptor-1 levels were significantly lower in patients with cardiosiderosis (odds ratio 21). This risk increased when transfusion-iron loading rates exceeded the erythroid transferrin uptake rate (derived from soluble transferrin receptor-1) by >0...
June 22, 2017: Haematologica
https://www.readbyqxmd.com/read/28642043/mitochondrial-cx43-an-important-component-of-cardiac-preconditioning
#3
REVIEW
Antonio Rodríguez-Sinovas, Marisol Ruiz-Meana, Amanda Denuc, David García-Dorado
Connexin 43 (Cx43) forms gap junction channels that are essential for the propagation of electrical depolarization in cardiomyocytes, but also with important roles in the pathophysiology of reperfusion injury. However, more recent studies have shown that Cx43 has also important functions independent from intercellular communication between adjacent cardiomyocytes. Some of these actions have been related to the presence of Cx43 in the mitochondria of these cells (mitoCx43). The functions of mitoCx43 have not been completely elucidated, but there is strong evidence indicating that mitoCx43 modulates mitochondrial respiration at respiratory complex I, production of radical oxygen species and ATP synthesis...
June 19, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28641323/ischaemia-reperfusion-injury-and-hyperbaric-oxygen-pathways-a-review-of-cellular-mechanisms
#4
REVIEW
Ashish Francis, Richard Baynosa
Ischaemia-induced tissue injury has wide-ranging clinical implications including myocardial infarction, stroke, compartment syndrome, ischaemic renal failure and replantation and revascularization. However, the restoration of blood flow produces a 'second hit' phenomenon, the effect of which is greater than the initial ischaemic event and characterizes ischaemia-reperfusion (IR) injury. Some examples of potential settings of IR injury include: following thrombolytic therapy for stroke, invasive cardiovascular procedures, solid organ transplantation, and major trauma resuscitation...
June 2017: Diving and Hyperbaric Medicine: the Journal of the South Pacific Underwater Medicine Society
https://www.readbyqxmd.com/read/28638482/implantable-and-biodegradable-macroporous-iron-oxide-frameworks-for-efficient-regeneration-and-repair-of-infracted-heart
#5
Wenshuo Wang, Hongyue Tao, Yun Zhao, Xiaotian Sun, Jing Tang, Cordelia Selomulya, Jia Tang, Tianchan Chen, Yang Wang, Minglei Shu, Lei Wei, Guanyu Yi, Jixue Zhou, Lai Wei, Chunsheng Wang, Biao Kong
The construction, characterization and surgical application of a multilayered iron oxide-based macroporous composite framework were reported in this study. The framework consisted of a highly porous iron oxide core, a gelatin-based hydrogel intermediary layer and a matrigel outer cover, which conferred a multitude of desirable properties including excellent biocompatibility, improved mechanical strength and controlled biodegradability. The large pore sizes and high extent of pore interconnectivity of the framework stimulated robust neovascularization and resulted in substantially better cell viability and proliferation as a result of improved transport efficiency for oxygen and nutrients...
2017: Theranostics
https://www.readbyqxmd.com/read/28638422/cognitive-impairment-among-patients-with-chronic-obstructive-pulmonary-disease-compared-to-normal-individuals
#6
Mitra Samareh Fekri, Seyed-Mehdi Hashemi-Bajgani, Ahmad Naghibzadeh-Tahami, Fateme Arabnejad
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is one of the most important causes of morbidity and mortality worldwide. The complications of COPD are numerous, and cognitive impairment is one of the most common complications that relates to mortality and morbidity directly. The present study was conducted with the aim of evaluating the prevalence of cognitive impairment in patients with COPD in comparison to normal individuals. MATERIALS AND METHODS: In this case-control study, 87 patients with COPD, whose diagnoses were confirmed by a pulmonologist based on the spirometry test findings, were included...
2017: Tanaffos
https://www.readbyqxmd.com/read/28636634/cardiomyopathy-development-protection-after-myocardial-infarction-in-rats-successful-competition-for-major-dihydropyridines-common-metabolite-against-captopril
#7
Katarzyna A Mitręga, Adrianna M Spałek, Jerzy Nożyński, Maurycy Porc, Magdalena Stankiewicz, Tadeusz F Krzemiński
During the last 25 years angiotensin-converting enzyme inhibitors spectacularly conquered the field of cardiovascular diseases therapy. Nevertheless, lack of new studies concerning side effects associated with their chronic administration seems to be rather confusing. In our previous research, we proved that the main furnidipines' metabolite (M-2) possess multiple cardioprotective actions. Currently, we compared effects of post-infarction long-term oral treatment with M-2 and captopril on hemodynamic parameters and "ischemic cardiomyopathy" development in rats...
2017: PloS One
https://www.readbyqxmd.com/read/28634219/early-use-of-n-acetylcysteine-nac-with-nitrate-therapy-in-patients-undergoing-primary-percutaneous-coronary-intervention-for-st-segment-elevation-myocardial-infarction-reduces-myocardial-infarct-size-the-naciam-trial
#8
Sivabaskari Pasupathy, Rosanna Tavella, Suchi Grover, Betty Raman, Nathan E K Procter, Yang T Du, Gnanadevan Mahadavan, Irene Stafford, Tamila Heresztyn, Andrew Holmes, Christopher Zeitz, Margaret Arstall, Joseph B Selvanayagam, John D Horowitz, John F Beltrame
Background -Contemporary ST-elevation myocardial infarction (STEMI) management involves primary percutaneous coronary intervention (PCI) with on-going studies focusing on infarct size reduction utilizing ancillary therapies. N-acetylcysteine (NAC) is an antioxidant with reactive oxygen species scavenging properties that also potentiates the effects of nitroglycerin (NTG) and thus represents a potentially beneficial ancillary therapy in primary PCI. The NACIAM (NACIn Acute Myocardial infarction) trial examined the effects of NAC on infarct size in STEMI patients undergoing PCI...
June 20, 2017: Circulation
https://www.readbyqxmd.com/read/28633867/review-of-a-causal-role-of-fructose-containing-sugars-in-myocardial-susceptibility-to-ischemia-reperfusion-injury
#9
REVIEW
Gerald J Maarman, Amy E Mendham, Kim Lamont, Cindy George
In 2012, the World Health Organization Global Status Report on noncommunicable diseases showed that 7.4 million deaths were due to ischemic heart disease. Consequently, cardiovascular disease is a significant health burden, especially when partnered with comorbidities such as obesity, metabolic syndrome, and type 2 diabetes mellitus. Of note, these diseases can all be induced or exacerbated by diet. Carbohydrates, in particular, fructose and glucose, generally form the largest part of the human diet. Accumulating evidence from animal studies suggests that if large amounts of fructose are consumed either in isolation or in combination with glucose (fructose-containing sugars), myocardial susceptibility to ischemia/reperfusion (I/R) injury increases...
June 2017: Nutrition Research
https://www.readbyqxmd.com/read/28630913/an-innovative-biologic-system-for-photon-powered-myocardium-in-the-ischemic-heart
#10
Jeffrey E Cohen, Andrew B Goldstone, Michael J Paulsen, Yasuhiro Shudo, Amanda N Steele, Bryan B Edwards, Jay B Patel, John W MacArthur, Michael S Hopkins, Casey E Burnett, Kevin J Jaatinen, Akshara D Thakore, Justin M Farry, Vi N Truong, Alexandra T Bourdillon, Lyndsay M Stapleton, Anahita Eskandari, Alexander S Fairman, William Hiesinger, Tatiana V Esipova, William L Patrick, Keven Ji, Judith A Shizuru, Y Joseph Woo
Coronary artery disease is one of the most common causes of death and disability, afflicting more than 15 million Americans. Although pharmacological advances and revascularization techniques have decreased mortality, many survivors will eventually succumb to heart failure secondary to the residual microvascular perfusion deficit that remains after revascularization. We present a novel system that rescues the myocardium from acute ischemia, using photosynthesis through intramyocardial delivery of the cyanobacterium Synechococcus elongatus...
June 2017: Science Advances
https://www.readbyqxmd.com/read/28629836/opposite-effects-of-catalase-and-mnsod-ectopic-expression-on-stress-induced-defects-and-mortality-in-the-desmin-deficient-cardiomyopathy-model
#11
Kleopatra Rapti, Antigoni Diokmetzidou, Ismini Kloukina, Derek J Milner, Aimilia Varela, Constantinos H Davos, Yassemi Capetanaki
Oxidative stress has been linked strongly to cell death and cardiac remodeling processes, all hallmarks of heart failure. Mice deficient for desmin (des-/-), the major muscle specific intermediate filament protein, develop dilated cardiomyopathy and heart failure characterized by mitochondrial defects and cardiomyocyte death. The cellular and biochemical alterations in the hearts of these mice strongly suggest that oxidative stress is one of the mechanisms contributing to the pathogenesis of the phenotype. Recently, we showed that indeed the desmin deficient cardiomyocytes are under increased oxidative stress...
June 16, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28629086/enhancing-internalization-of-silica-particles-in-myocardial-cells-through-surface-modification
#12
Nancy Ornelas-Soto, Rodrigo Rubio-Govea, Carlos E Guerrero-Beltrán, Eduardo Vázquez-Garza, Judith Bernal-Ramírez, Alejandra García-García, Yuriana Oropeza-Almazán, Gerardo García-Rivas, Flavio F Contreras-Torres
Surface modification in nanostructured mesoporous silica particles (MSNs) can significantly increase the uptake in myocardial cells. Herein, MSNs particles were synthesized and chemically functionalized to further assess their biocompatibility in rat myocardial cell line H9c2. The surface modification resulted in particles with an enhanced cellular internallization (3-fold increase) with respect to pristine particles. Apoptosis events were not evident at all, while necrosis incidence was significant only at a higher doses (>500μg/mL)...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28622359/aerobic-exercise-protects-against-pressure-overload-induced-cardiac-dysfunction-and-hypertrophy-via-%C3%AE-3-ar-nnos-no-activation
#13
Bin Wang, Ming Xu, Wenju Li, Xiaoli Li, Qiangsun Zheng, Xiaolin Niu
Aerobic exercise confers sustainable protection against cardiac hypertrophy and heart failure (HF). Nitric oxide synthase (NOS) and nitric oxide (NO) are known to play an important role in exercise-mediated cardioprotection, but the mechanism of NOS/NO stimulation during exercise remains unclear. The aim of this study is to determine the role of β3-adrenergic receptors (β3-ARs), NOS activation, and NO metabolites (nitrite and nitrosothiols) in the sustained cardioprotective effects of aerobic exercise. An HF model was constructed by transverse aortic constriction (TAC)...
2017: PloS One
https://www.readbyqxmd.com/read/28618428/the-impact-of-circulating-mitochondrial-dna-on-cardiomyocyte-apoptosis-and-myocardial-injury-after-tlr4-activation-in-experimental-autoimmune-myocarditis
#14
Bangwei Wu, Huanchun Ni, Jian Li, Xinyu Zhuang, Jinjin Zhang, Zhiyong Qi, Qiying Chen, Zhichao Wen, Haiming Shi, Xinping Luo, Bo Jin
BACKGROUND/AIMS: Mitochondrial DNA (mtDNA), acting as a newly found 'danger-associated molecular patterns' (DAMPs), is released into circulation upon tissue injury and performs as a considerable activator of inflammation and immune response. However, the role of circulating mtDNA in experimental autoimmune myocarditis (EAM) as well as Toll like receptor4 (TLR4) mediated cardiac inflammation and injury remains unknown. METHODS: A model of EAM was established in BALB/c mice by immunization with porcine cardiac myosin...
June 15, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28617869/statins-are-related-to-impaired-exercise-capacity-in-males-but-not-females
#15
Martin Bahls, Stefan Groß, Till Ittermann, Raila Busch, Sven Gläser, Ralf Ewert, Henry Völzke, Stephan B Felix, Marcus Dörr
BACKGROUND: Exercise and statins reduce cardiovascular disease (CVD). Exercise capacity may be assessed using cardiopulmonary exercise testing (CPET). Whether statin medication is associated with CPET parameters is unclear. We investigated if statins are related with exercise capacity during CPET in the general population. METHODS: Cross-sectional data of two independent cohorts of the Study of Health in Pomerania (SHIP) were merged (n = 3,500; 50% males). Oxygen consumption (VO2) at peak exercise (VO2peak) and anaerobic threshold (VO2@AT) was assessed during symptom-limited CPET...
2017: PloS One
https://www.readbyqxmd.com/read/28617849/protective-effect-of-hdl-on-nadph-oxidase-derived-super-oxide-anion-mediates-hypoxia-induced-cardiomyocyte-apoptosis
#16
Su-Ying Wen, Shanmugam Tamilselvi, Chia-Yao Shen, Cecilia Hsuan Day, Li-Chin Chun, Li-Yi Cheng, Hsiu-Chung Ou, Ray-Jade Chen, Vijaya Padma Viswanadha, Wei-Wen Kuo, Chih-Yang Huang
Cardiovascular diseases are the leading cause of death of death in Taiwan. Atherosclerosis can lead to serious problems, including heart attack, stroke, or even death. Coronary heart disease (CHD) occurs when plaque builds up in the coronary arteries to cause the ischemic heart disease which will enhance myocardial remodeling and also induce myocardial hypoxia. High density lipoprotein (HDL) has been proposed to have cardio-protective effects. Under hypoxic conditions (1%O2 for 24hr), in H9c2 cells, reactive oxygen species (ROS) is induced which leads to cardiomyocyte apoptosis and cardiac dysfunction...
2017: PloS One
https://www.readbyqxmd.com/read/28616565/lactated-ringer-s-solution-for-preventing-myocardial-reperfusion-injury
#17
Takashi Koyama
Reperfusion of ischemic myocardium is crucial for salvaging myocardial cells from ischemic cell death. However, reperfusion itself induces various deleterious effects on the ischemic myocardium. These effects, known collectively as reperfusion injury, comprise stunned myocardium, reperfusion-induced arrhythmia, microvascular reperfusion injury, and lethal reperfusion injury. No approach has proven successful in preventing any of these injuries in the clinical setting. My colleagues and I recently proposed a new postconditioning protocol, postconditioning with lactate-enriched blood (PCLeB), for the prevention of reperfusion injury...
June 2017: IJC Heart & Vasculature
https://www.readbyqxmd.com/read/28614093/central-diastolic-pressure-decay-mediates-the-relationship-between-aortic-stiffness-and-myocardial-viability-potential-implications-for-aortosclerosis-induced-myocardial-ischemia
#18
Junichiro Hashimoto, Sadayoshi Ito
OBJECTIVE: Stiffening of the aorta often precedes coronary events, but little is known about the aetiological mechanism. We hypothesized that the predisposition to myocardial ischemia could be attributable to aortosclerosis-induced alterations in the central haemodynamics during diastole. METHODS: Using noninvasive tonometry and ultrasonography, we investigated the arterial pressure pulse waveforms, pulse wave velocities (PWVs) and compliance in 222 patients with hypertension...
June 16, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28611032/genome-wide-dynamics-of-nascent-noncoding-rna-transcription-in-porcine-heart-after-myocardial-infarction
#19
Minna U Kaikkonen, Paavo Halonen, Oscar Hsin-Fu Liu, Tiia A Turunen, Juho Pajula, Pierre Moreau, Ilakya Selvarajan, Tomi Tuomainen, Einari Aavik, Pasi Tavi, Seppo Ylä-Herttuala
BACKGROUND: Microarrays and RNA sequencing are widely used to profile transcriptome remodeling during myocardial ischemia. However, the steady-state RNA analysis lacks in sensitivity to detect all noncoding RNA species and does not provide separation between transcriptional and post-transcriptional regulations. Here, we provide the first comprehensive analysis of nascent RNA profiles of mRNAs, primary micro-RNAs, long noncoding RNAs, and enhancer RNAs in a large animal model of acute infarction...
June 2017: Circulation. Cardiovascular Genetics
https://www.readbyqxmd.com/read/28610437/a-new-ferulic-acid-ester-from-rhodiola-wallichiana-var-cholaensis-crassulaceae
#20
Yaling Song, Jianming Zhou, Xuejing Wang, Xue Xie, Yiwu Zhao, Fuyong Ni, Wenzhe Huang, Zhenzhong Wang, Wei Xiao
A new ferulic acid ester, 6-feruloyloxyhexanoic acid (1), was isolated along with 10 known ones (2-11), from the concentrated water extract of Rhodiola wallichiana var. cholaensis. Their chemical structures were elucidated on the basis of extensive spectroscopic methods including Two-dimensional nuclear magnetic resonance (2D NMR) experiments. Compound 3 was isolated from this plant for the first time. The protective effects against H2O2-induced myocardial cell injury in cultured H9c2 cells were also evaluated...
June 14, 2017: Natural Product Research
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