Wanze Ni, Xuping Gao, Xin Su, Jun Cai, Shiwen Zhang, Lu Zheng, Jiazi Liu, Yonghui Feng, Shiyun Chen, Junrong Ma, Wenting Cao, Fangfang Zeng
INTRODUCTION: The association between extreme birth spacing and adverse outcomes is controversial, and available evidence is fragmented into different classifications of birth spacing. MATERIAL AND METHODS: We conducted a systematic review of observational studies to evaluate the association between birth spacing (i.e., interpregnancy interval and interoutcome interval) and adverse outcomes (i.e., pregnancy complications, adverse birth outcomes). Pooled odds ratios (ORs) with 95% confidence intervals (CI) were calculated using a random-effects model, and the dose-response relationships were evaluated using generalized least squares trend estimation...
December 2023: Acta Obstetricia et Gynecologica Scandinavica