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complication of infant of diabetic mother

Lucilla Poston, Rishi Caleyachetty, Sven Cnattingius, Camila Corvalán, Ricardo Uauy, Sharron Herring, Matthew W Gillman
Obesity in women of reproductive age is increasing in prevelance worldwide. Obesity reduces fertility and increases time taken to conceive, and obesity-related comorbidities (such as type 2 diabetes and chronic hypertension) heighten the risk of adverse outcomes for mother and child if the woman becomes pregnant. Pregnant women who are obese are more likely to have early pregnancy loss, and have increased risk of congenital fetal malformations, delivery of large for gestational age infants, shoulder dystocia, spontaneous and medically indicated premature birth, and stillbirth...
October 10, 2016: Lancet Diabetes & Endocrinology
Sofie Ingdam Halkjaer, Lisbeth Nilas, Emma Malchau Carlsen, Dina Cortes, Thórhallur Ingi Halldórsson, Sjúrdur Frodi Olsen, Anders Elm Pedersen, Karen Angeliki Krogfelt, Andreas Munk Petersen
BACKGROUND: Maternal obesity is associated with increased risks of adverse pregnancy-related complications and outcomes for both mothers and infants. Overweight and obese women have an increased risk of pregnancy-induced hypertension, preeclampsia and gestational diabetes mellitus (GDM). Infant Body Mass index (BMI) and the risk of obesity in adulthood are related to maternal gestational weight gain (GWG). Preventive lifestyle and dietary interventions are time-consuming and do not always reduce GWG or the risk of maternal pregnancy complications...
October 11, 2016: Trials
M B Azad, B L Moyce, L Guillemette, C D Pascoe, B Wicklow, J M McGavock, A J Halayko, V W Dolinsky
Diabetes is an increasingly common complication of pregnancy. In parallel with this trend, a rise in chronic lung disease in children has been observed in recent decades. While several adverse health outcomes associated with exposure to diabetes in utero have been documented in epidemiological and experimental studies, few have examined the impact of diabetes in pregnancy on offspring lung health and respiratory disease. We provide a comprehensive overview of current literature on this topic, finding suggestive evidence that exposure to diabetes in utero may have adverse effects on lung development...
August 19, 2016: Paediatric Respiratory Reviews
Fauzia Mohsin, Shareen Khan, Md Abdul Baki, Bedowra Zabeen, Kiswhar Azad
Women with diabetes in pregnancy, either pre-gestational Diabetes Mellitus (Type 1 & Type 2) or Gestational Diabetes, are at increased risk for adverse pregnancy outcomes, including preterm labour and increased foetal mortality rate. Adequate glycaemic control before and during pregnancy is crucial for improving foetal and perinatal outcomes in these babies. Perinatal and neonatal morbidities and mortality rates have declined since the development of specialized maternal, foetal, and neonatal care for women with diabetes and their offspring...
September 2016: JPMA. the Journal of the Pakistan Medical Association
Fauzia Mohsin, Shareen Khan, Md Abdul Baki, Bedowra Zabeen, Kiswhar Azad
Women with diabetes in pregnancy, either pre-gestational Diabetes Mellitus (Type 1 & Type 2) or Gestational Diabetes, are at increased risk for adverse pregnancy outcomes, including preterm labour and increased foetal mortality rate. Adequate glycaemic control before and during pregnancy is crucial for improving foetal and perinatal outcomes in these babies. Perinatal and neonatal morbidities and mortality rates have declined since the development of specialized maternal, foetal, and neonatal care for women with diabetes and their offspring...
September 2016: JPMA. the Journal of the Pakistan Medical Association
Joice Monaliza Vernini, Jusciele Brogin Moreli, Claudia Garcia Magalhães, Roberto Antônio Araújo Costa, Marilza Vieira Cunha Rudge, Iracema Mattos Paranhos Calderon
BACKGROUND: Overweight and obesity are associated with pregnancy complications and adverse perinatal outcomes, posing short and long-term risks for maternal and child health. This study evaluated maternal, delivery and neonatal outcomes in pregnancies complicated by overweight and obesity. METHODS: This prospective cross-sectional study included 258 pregnant women. According to prepregnancy body mass index (BMI), participants were classified as normal weight, overweight, or obese...
2016: Reproductive Health
Anthea Gibbons, Christopher Flatley, Sailesh Kumar
OBJECTIVE: This study aimed to assess the relationship between the cerebroplacental ratio (CPR) and intrapartum and perinatal outcomes in pregnancies complicated by gestational diabetes mellitus. METHODS: This was a retrospective cohort study of women diagnosed with gestational diabetes mellitus (GDM) birthing at the Mater Mothers' Hospital in Brisbane between 2007 and 2015. The CPR in 1089 non-anomalous singleton fetuses measured between 34 + 0 and 36 + 6 weeks gestation was compared between types of GDM treatment groups and correlated with intrapartum and perinatal outcomes...
August 22, 2016: Ultrasound in Obstetrics & Gynecology
Mitra Behrashi, Mansooreh Samimi, Tayyebeh Ghasemi, Farzaneh Saberi, Fatemeh Atoof
BACKGROUND: Untreated or poorly controlled gestational diabetes can cause serious complications for mother and newborn. Glibenclamide is rarely used in treating mothers with this disease. This study aimed at comparing the effect of glibenclamide and insulin on neonatal outcomes in women with gestational diabetes mellitus. METHODS: In this randomized controlled clinical trial, 249 pregnant women aged 18-45 years within the 11(th)-33(rd) weeks of gestation with gestational diabetes, single fetus pregnancy, and in need of hyperglycemia treatment were entered and grouped randomly as either glibenclamide or insulin...
2016: International Journal of Preventive Medicine
Prosper Kakudji Luhete, Olivier Mukuku, Patrick Mubinda Kiopin, Albert Mwembo Tambwe, Prosper Kalenga Muenze Kayamba
INTRODUCTION: Fetal macrosomia is usually defined when the estimated fetal weight is greater than or equal to 4000 grams. The aim of this study was to determine the incidence of macrosomia, to identify its etiological factors and to evaluate maternal and perinatal prognosis. METHODS: This is a case-control study conducted in maternity units of 10 general referral hospitals in the city of Lubumbashi in Democratic Republic of Congo between 1 December 2013 and 31 March 2014...
2016: Pan African Medical Journal
Jose Maria Lloreda-García, Sandra Sevilla-Denia, Alba Rodríguez-Sánchez, Pablo Muñoz-Martínez, Marta Díaz-Ruiz
OBJECTIVE: To assess the incidence and perinatal complications of macrosomic infants born to diabetic and non-diabetic mothers. PATIENTS AND METHODS: A six-year retrospective study of newborns at our hospital. A total of 996 macrosomic newborns were found. Maternal characteristics, mode of delivery, and perinatal outcomes were studied. RESULTS: Of 18005 newborns, 996 were macrosomic infants (5.53%). Of these, 103 (10.3%) were born to diabetic mothers...
October 2016: Endocrinología y Nutrición: órgano de la Sociedad Española de Endocrinología y Nutrición
Daisuke Sugawara, Asami Maruyama, Toshiyuki Imanishi, Yohei Sugiyama, Ko Ichihashi
BACKGROUND: This study was conducted to investigate whether glycated albumin is a useful glycemic marker from the point of view of infant complications for monitoring glycemic control in pregnant women with diabetes or gestational diabetes mellitus. METHODS: We retrospectively studied 42 Japanese infants of diabetic mothers and their mothers at our facility between May 2010 and July 2013. The mean glycated albumin and glycated hemoglobin levels were compared between mothers of infants with complications and those without complications...
April 2, 2016: Pediatrics and Neonatology
S Danieli-Gruber, A Maayan-Metzger, I Schushan-Eisen, T Strauss, L Leibovitch
OBJECTIVES: To evaluate perinatal morbidity and mortality among preterm neonates who were born to overweight and obese mothers compared to preterm neonates who were born to mothers with normal pre-pregnancy body mass index (BMI). METHODS: Retrospective recordings of medical charts of 110 preterm infants born to overweight (n = 68) and obese (n = 42) mothers at gestational age (GA) 28-34 weeks, as well as 110 controls matched for GA and birth weight. All infants were born at the Sheba Medical Center between 2007 and 2014...
May 5, 2016: Journal of Maternal-fetal & Neonatal Medicine
Wen-Yuan Jin, Sheng-Liang Lin, Ruo-Lin Hou, Xiao-Yang Chen, Ting Han, Yan Jin, Li Tang, Zhi-Wei Zhu, Zheng-Yan Zhao
BACKGROUND: Dyslipidemia in pregnancy are associated with gestational diabetes mellitus (GDM), preeclampsia, preterm birth and other adverse outcomes, which has been extensively studied in western countries. However, similar studies have rarely been conducted in Asian countries. Our study was aimed at investigating the associations between maternal dyslipidemia and adverse pregnancy outcomes among Chinese population. METHODS: Data were derived from 934 pairs of non-diabetic mothers and neonates between 2010 and 2011...
2016: BMC Pregnancy and Childbirth
Jeddú Cruz, Raiden Grandía, Liset Padilla, Suilbert Rodríguez, Pilar Hernández García, Jacinto Lang Prieto, Antonio Márquez-Guillén
INTRODUCTION Fetal macrosomia is the most important complication in infants of women with diabetes, whether preconceptional or gestational. Its occurrence is related to certain maternal and fetal conditions and negatively affects maternal and perinatal outcomes. The definitive diagnosis is made at birth if a newborn weighs >4000 g. OBJECTIVE Identify which maternal and fetal conditions could be macrosomia predictors in infants born to Cuban mothers with gestational diabetes. METHODS A case-control study comprising 236 women with gestational diabetes who bore live infants (118 with macrosomia and 118 without) was conducted in the América Arias University Maternity Hospital, Havana, Cuba, during 2002-2012...
July 2015: MEDICC Review
Trecia A Wouldes, Malcolm Battin, Suzette Coat, Elaine C Rush, William M Hague, Janet A Rowan
OBJECTIVE: Gestational diabetes mellitus (GDM) is a common complication of pregnancy and is increasingly being treated with metformin that crosses the placenta rather than insulin, which does not. This study seeks to examine the neurodevelopment of offspring of women treated with metformin or insulin for GDM. DESIGN: We performed a prospective follow-up study of children whose mothers had been randomly assigned at 20-33 weeks gestation to treatment with metformin or insulin for GDM...
February 24, 2016: Archives of Disease in Childhood. Fetal and Neonatal Edition
D Aled Rees, Sara Jenkins-Jones, Christopher L Morgan
This study aimed to determine the effect of PCOS upon fertility, pregnancy, and neonatal outcomes. Fertility rates may be restored to those of the background population after diagnosis. Adverse pregnancy and neonatal outcomes are more prevalent for women with PCOS independently of obesity.
April 2016: Journal of Clinical Endocrinology and Metabolism
You-Lin Tain, Hsing Luh, Ching-Yuang Lin, Chien-Ning Hsu
Congenital anomalies of the kidney and urinary tract (CAKUT) are 1 of the major factors in young adults needing renal replacement therapy, but there is little extensive assessment of their incidence and risk factors. This study aimed to evaluate trends in the incidence of and risk factors for CAKUT among all births in Taiwan.This population-based case-control study design was conducted using the Taiwan national births registry, which contains detailed information about maternal health and characteristics of newborns, supplied by health professionals...
February 2016: Medicine (Baltimore)
Cheryl Pui Yan Au, Camille H Raynes-Greenow, Robin M Turner, Angela E Carberry, Heather E Jeffery
OBJECTIVE: Pregnancies complicated with gestational diabetes mellitus (GDM) are at a higher risk for caesarean and instrumental deliveries as well as adverse neonatal outcomes such as fetal overgrowth, hypoglycaemia and neonatal intensive care admission. Our primary objective was to describe neonatal outcomes in a sample that included term infants of both GDM mothers and mothers with normal glucose tolerance (NGT). DESIGN AND SETTING: this cross-sectional study included 599 term babies born between September and October 2010 at Royal Prince Alfred Hospital, Sydney, Australia...
March 2016: Midwifery
S Ponrartana, F Goodarzian, S Emadi, P C Aggabao, C L Fisher, V Gilsanz
OBJECTIVE: To examine whether the presence of intra-abdominal fat (IAF) in newborns is diagnostic of infants of diabetic mothers (IDMs), and determine whether IAF is merely the consequence of increased body size. STUDY DESIGN: Abdominal radiographs of 277 neonates >34 weeks gestational age (147 male and 130 female) were reviewed to determine the presence of IAF. Unpaired t-test and regression analyses were used to examine the influence of gestational age, birth weight, birth length and maternal diabetes on the prevalence and thickness of IAF...
May 2016: Journal of Perinatology: Official Journal of the California Perinatal Association
Joanne Darke, Svetlana V Glinianaia, Philippa Marsden, Ruth Bell
INTRODUCTION: The incidence of pregnancies complicated by twinning and diabetes is increasing in the UK. This is a worrying trend as both diabetes and twin gestations are associated with a high risk of adverse pregnancy outcomes. The few studies that have specifically addressed how twinning and pregestational diabetes in the same pregnancy may affect outcome have reported conflicting results. MATERIAL AND METHODS: We analyzed data on 27 women with a twin pregnancy and pregestational diabetes (54 babies) and 6407 women with a twin pregnancy without diabetes (12 814 babies) from the Northern Survey of Twin and Multiple Pregnancy during 1998-2010...
March 2016: Acta Obstetricia et Gynecologica Scandinavica
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