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https://www.readbyqxmd.com/read/28943569/intrahepatic-cholangiolocellular-and-cholangiocellular-carcinoma-differences-in-the-18f-fdg-pet-ct-findings
#1
Yoshiko Takahashi, Shuichi Sato, Hitomi Ishitobi, Makoto Nagaoka, Yoshiya Kobayashi, Hiroyuki Fukuhara, Mika Yuki, Yoshinori Komazawa, Hiroyuki Kuroda, Toshihiro Shizuku
Cholangiolocellular carcinoma is a minor primary cancerous tumor of the liver and its coexistence with intrahepatic cholangiocarcinoma in the liver is rare. We herein report a case of concurrent cholangiolocellular carcinoma and intrahepatic cholangiocarcinoma in the liver, in addition to a rectal G1 neuroendocrine tumor, a so-called carcinoid. The intrahepatic tumors showed a different uptake in the 18-fluoro-2-deoxyglucose (FDG) positron-emission tomography (PET)/computed tomography (CT) findings. In addition to conventional dynamic contrast-enhanced CT, we concluded that FDG PET/CT could therefore be a helpful modality to identify the properties of both cholangiolocellular carcinoma and intrahepatic cholangiocarcinoma...
September 25, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28943046/radical-radiation-therapy-for-oligometastatic-breast-cancer-results-of-a-prospective-phase-ii-trial
#2
Marco Trovo, Carlo Furlan, Jerry Polesel, Francesco Fiorica, Stefano Arcangeli, Niccolò Giaj-Levra, Filippo Alongi, Alessandro Del Conte, Loredana Militello, Elena Muraro, Debora Martorelli, Simon Spazzapan, Massimiliano Berretta
BACKGROUND AND PURPOSE: We conducted a prospective phase II multicentric trial to determine if radical radiation therapy to all metastatic sites might improve the progression-free survival (PFS) in oligometastatic breast cancer patients. Secondary endpoints were local control (LC), overall survival (OS) and toxicity. METHODS AND MATERIALS: Inclusion criteria were the following: oligometastatic breast cancer with ≤5 metastatic sites, FDG-PET/CT staging, no brain metastases, primary tumor controlled...
September 21, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28941755/the-diagnostic-value-of-fdg-and-amyloid-pet-in-alzheimer-s-disease-a-systematic-review
#3
REVIEW
Louise Rice, Sotirios Bisdas
PURPOSE: By 2050 it is projected that 115 million people worldwide will have Alzheimer's Disease (AD) [1]. Recent attempts have been made to redefine the diagnostic criteria of AD to include markers of neurodegeneration - measurable by FDG-PET - and markers of amyloid accumulation - measurable by amyloid-PET. MATERIALS AND METHODS: A systematic review of the literature was performed to examine the current diagnostic use of amyloid and FDG PET. MEDLINE and EMBASE databases and the Cochrane Database were searched for relevant papers RESULTS AND DISCUSSION: This search resulted in twenty-nine papers on amyloid imaging, twenty-three papers on FDG-PET and eight papers which utilized both techniques...
September 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28941158/prognostic-and-predictive-role-of-18-f-fluorodeoxyglucose-positron-emission-tomography-fdg-pet-in-patients-with-unresectable-malignant-pleural-mesothelioma-mpm-treated-with-up-front-pemetrexed-based-chemotherapy
#4
Paolo Andrea Zucali, Egesta Lopci, Giovanni Luca Ceresoli, Laura Giordano, Matteo Perrino, Gianluigi Ciocia, Letizia Gianoncelli, Elena Lorenzi, Matteo Simonelli, Fabio De Vincenzo, Lucia Rebecca Setti, Cristiana Bonifacio, Maria Bonomi, Emilio Bombardieri, Arturo Chiti, Armando Santoro
The aim of this study was to evaluate the role of metabolic parameters analyzed at baseline and at interim FDG-PET in predicting disease outcome in unresectable MPM patients receiving pemetrexed-based chemotherapy. A consecutive series of MPM patients treated between February 2004 and July 2013 with first-line pemetrexed-based chemotherapy, and evaluated by FDG-PET and CT scan at baseline and after two cycles of chemotherapy, was reviewed. Best CT scan response was assessed according to modified RECIST criteria...
September 21, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28940101/the-role-of-interim-fdg-pet-ct-after-induction-chemotherapy-as-a-predictor-of-concurrent-chemoradiotherapy-efficacy-and-prognosis-for-head-and-neck-cancer
#5
Ka-Rham Kim, Hyun-Jeong Shim, Jun-Eul Hwang, Sang-Hee Cho, Ik-Joo Chung, Ki Seong Park, Sae-Ryung Kang, Seong Young Kwon, Woong-Ki Chung, Woo Kyun Bae
PURPOSE: Induction chemotherapy (ICT) with docetaxel, cisplatin, and 5-fluorouracil (TPF) followed by concurrent chemoradiotherapy (CCRT) has the advantages of organ preservation and systemic control in head and neck cancer (HNC). Early prediction of CCRT efficacy may help identify patients who will benefit more from surgery than from CCRT. We investigated the role of interim 18-fluoro-2-deoxy-glucose positron emission tomography computed tomography (FDG PET-CT) after ICT to predict the efficacy of CCRT and clinical outcomes...
September 22, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28939071/intraindividual-homogeneity-of-18-f-fdg-pet-ct-parameters-in-hpv-positive-opscc
#6
Shachi Jenny Sharma, Claus Wittekindt, Jennifer Knuth, Dagmar Steiner, Nora Wuerdemann, Maren Laur, Tobias Kroll, Steffen Wagner, Jens Peter Klussmann
OBJECTIVES: (18)F-FDG PET/CT is widely used in clinical oncology. Human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (OPSCC) represents an emerging disease that differs from HPV-negative OPSCC in clinical behavior and tumour biology. In these tumours, HPV-oncogenes might lead to distinct alterations in metabolic pathways. Therefore, we compared metabolic parameters using (18)F-FDG PET/CT in HPV-positive and HPV-negative OPSCC in relation to histopathological findings...
October 2017: Oral Oncology
https://www.readbyqxmd.com/read/28938677/comparison-of-18-fdg-pet-pet-ct-and-bone-scintigraphy-for-detecting-bone-metastases-in-patients-with-nasopharyngeal-cancer-a-meta-analysis
#7
Chuanhui Xu, Ruiming Zhang, Huanlei Zhang, Zhenyan Zhang
OBJECTIVE: We performed a meta-analysis to compare the diagnostic efficacy of (18)FDG PET/PET-CT and bone scintigraphy (BS) for diagnosing bone metastatic cancers in nasopharyngeal cancer patients. RESULTS: 6 studies (1238 patients) fulfilled the inclusion criteria. The pooled sensitivities for (18)FDG PET/PET-CT and BS were 0.81 (95% confidence interval [CI] = 0.70 to 0.98) and 0.39 (95% CI = 0.26 to 0.54), specificities were 0.99 (95% CI = 0.98 to 0.99) and 0...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938220/metabolic-correlate-of-memory-deficit-awareness-in-dementia-with-lewy-bodies-implication-in-cortical-midline-structure
#8
Tomomichi Iizuka, Masashi Kameyama
The neural substrate of memory-deficit awareness has been studied in mild cognitive impairment and Alzheimer's disease (AD). However, little is known about that in dementia with Lewy bodies (DLB). To determine the neural substrates of memory-deficit awareness in DLB, we investigated the relationship between awareness of memory-deficit and glucose metabolism in DLB. Thirty-four patients with DLB were assessed by (18)F-FDG-PET and dopamine transporter (DAT)-SPECT. The awareness was evaluated using an awareness index that represents the discrepancy between objective and subjective memory scores...
September 13, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28937297/clinical-outcome-of-patients-with-early-stage-favorable-hodgkin-lymphoma-treated-with-abvd%C3%A2-%C3%A3-%C3%A2-two-cycles-followed-by-fdg-pet-ct-restaging-and-20%C3%A2-gy-of-involved-site-radiotherapy
#9
Sophia C Kamran, Heather A Jacene, Yu-Hui Chen, Peter M Mauch, Andrea K Ng
Our purpose was to assess outcome of patients with early-stage, favorable (per GHSG criteria) Hodgkin Lymphoma (HL) staged with FDG-PET/CT and treated with two cycles of adriamycin, bleomycin, vincristine, and dacarbazine (ABVD) followed by PET/CT assessment and involved-site radiotherapy (ISRT) to 20 Gy. Records of 23 patients who met eligibility criteria, treated between 2008 and 2016, were reviewed. PET response after two cycles of ABVD was independently assessed by a nuclear medicine physician. After two cycles of ABVD, 91...
September 22, 2017: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/28937268/real-time-intra-procedural-18f-fdg-pet-ct-guided-biopsy-using-automated-robotic-biopsy-arm-ara-in-the-evaluation-of-thoracic-lesions-with-prior-inconclusive-biopsy-results
#10
Renjith Kalathoorakathu Radhakrishnan, Bhagwant Rai Mittal, Arun Kumar Reddy Gorla, Rajender Kumar Basher, Ashwani Sood, Amanjit Bal, Naveen Kalra, Niranjan Khandelwal, Navneet Singh, Digambar Behera
OBJECTIVE: The aim of this study was to assess the feasibility and appraise the diagnostic utility of real time 18F-FDG PET/CT guided biopsy under automated robotic biopsy arm (ARA) guidance for the evaluation of thoracic lesions with prior inconclusive biopsy results. METHODS: PET/CT guided biopsy of thoracic lesions was performed in patients who had at least one previous inconclusive biopsy. A total of 25 patients (Male: Female- 18 males, 7 females; Age: Range- 13-75; mean- 53...
September 20, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28936601/texture-analysis-of-high-resolution-dedicated-breast-18-f-fdg-pet-images-correlates-with-immunohistochemical-factors-and-subtype-of-breast-cancer
#11
Alexis Moscoso, Álvaro Ruibal, Inés Domínguez-Prado, Anxo Fernández-Ferreiro, Míchel Herranz, Luis Albaina, Sonia Argibay, Jesús Silva-Rodríguez, Juan Pardo-Montero, Pablo Aguiar
PURPOSE: This study aims to determine whether PET textural features measured with a new dedicated breast PET scanner reflect biological characteristics of breast tumors. METHODS: One hundred and thirty-nine breast tumors from 127 consecutive patients were included in this analysis. All of them underwent a (18)F-FDG PET scan before treatment. Well-known PET quantitative parameters such as SUV m a x , SUV m e a n , metabolically active tumor volume (MATV) and total lesion glycolysis (TLG) were extracted...
September 21, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28936404/-18-f-fdg-pet-for-assessing-biological-viability-and-prognosis-in-liver-transplant-patients-with-hepatocellular-carcinoma
#12
REVIEW
Arno Kornberg, Martina Schernhammer, Helmut Friess
Liver transplantation (LT) has become standard of care in patients with non-resectable early stage hepatocellular carcinoma (HCC) in liver cirrhosis. Currently, patient selection for LT is strictly based on tumor size and number, provided by the Milan criteria. This may, however, exclude patients with advanced tumor load but favourable biology from a possibly curative treatment option. It became clear in recent years that biological tumor viability rather than tumor macromorphology determines posttransplant outcome...
September 28, 2017: Journal of Clinical and Translational Hepatology
https://www.readbyqxmd.com/read/28935243/fdg-pet-mr-imaging-in-alveolar-echinococcosis
#13
Felix Lötsch, Fredrik Waneck, Herbert Auer, Klaus Kaczirek, Georgios Karanikas, Michael Ramharter
No abstract text is available yet for this article.
September 18, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28934176/positron-emission-tomographic-imaging-elucidates-the-complex-relationship-between-glucose-uptake-and-tissue-blood-flow-mechanism-in-squamous-cell-oral-cancer-patients
#14
Ping Xu, Yan Li, Shuyong Yang, Mingzhe Li, Chenjun Li
BACKGROUND Through the clinical use of positron emission tomography, we aimed to elucidate the complex relationship between glucose uptake and squamous cell oral cancer (ScOC) growth, along with its mechanism with respect to tissue blood flow (tBF). MATERIAL AND METHODS We retrospectively reviewed a total of 69 newly diagnosed ScOC patients by Fluorine-18 fluorodeoxyglucose (18F-FDG) positron emission tomography (PET). Maximum and mean standard uptake values (SUV↑ and SUV) were recorded to assess glucose uptake...
September 21, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28932894/additive-value-of-amyloid-pet-in-routine-cases-of-clinical-dementia-work-up-after-fdg-pet
#15
Matthias Brendel, Jonas Schnabel, Sonja Schönecker, Leonie Wagner, Eva Brendel, Johanna Meyer-Wilmes, Marcus Unterrainer, Andreas Schildan, Marianne Patt, Catharina Prix, Nibal Ackl, Cihan Catak, Oliver Pogarell, Johannes Levin, Adrian Danek, Katharina Buerger, Peter Bartenstein, Henryk Barthel, Osama Sabri, Axel Rominger
PURPOSE: In recent years, several [(18)F]-labeled amyloid-PET tracers have been developed and have obtained clinical approval. Despite their widespread scientific use, studies in routine clinical settings are limited. We therefore investigated the impact of [(18)F]-florbetaben (FBB)-PET on the diagnostic management of patients with suspected dementia that was still unclarified after [(18)F]-fluordeoxyglucose (FDG)-PET. METHODS: All subjects were referred in-house with a suspected dementia syndrome due to neurodegenerative disease...
September 20, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28932562/standardized-uptake-value-and-radiological-density-attenuation-as-predictive-and-prognostic-factors-in-patients-with-solitary-pulmonary-nodules-our-experience-on-1-592-patients
#16
Duilio Divisi, Mirko Barone, Luca Bertolaccini, Gaetano Rocco, Piergiorgio Solli, Roberto Crisci
BACKGROUND: Multislice computed tomography (MSCT) increased detection of solitary pulmonary nodules (SPNs), changing the management based on radiological and clinical factors. When 18-fluorine fluorodeoxyglucose positron emission tomography combined with computed tomography ((18)F-FDG-PET/CT) was considered for the evaluation of nodules, the maximum standardized uptake value (SUVmax) more than 2.5 is used frequently as a cut off for malignancy. The purpose of this study is to evaluate SUVmax PET/CT and pulmonary attenuation patterns at MSCT in patients with SPN according to morphological and pathological characteristics of the lesion...
August 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28932548/predictors-of-conversion-to-thoracotomy-during-video-assisted-thoracoscopic-surgery-lobectomy-in-lung-cancer-additional-predictive-value-of-fdg-pet-ct-in-a-tuberculosis-endemic-region
#17
Chun Geun Lim, Kyung Min Shin, Ji Seun Lim, Jae Kwang Lim, Hye Jung Kim, Won Hwa Kim, Seung Hyun Cho, Seung Ick Cha, Eung Bae Lee, Yangki Seock, Shin Young Jeong
BACKGROUND: To evaluate the added clinical value of (18)F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) scans to chest CT imaging in predicting the conversion to thoracotomy during video-assisted thoracoscopic surgery (VATS) lobectomy in patients with lung cancer. METHODS: This is a retrospective study of 235 consecutive patients who underwent planned VATS lobectomy for primary lung cancer between 2011 and 2015. CT images were interpreted in terms of the presence and the attenuation of peribronchial lymph nodes (PLN) and peribronchial cuffs of soft (PCS) tissue, pleural calcification, and parenchymal calcified nodule...
August 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28931302/learning-metabolic-brain-networks-in-mci-and-ad-by-robustness-and-leave-one-out-analysis-an-fdg-pet-study
#18
Zhijun Yao, Bin Hu, Xuejiao Chen, Yuanwei Xie, Jürg Gutknecht, Dennis Majoe
This study attempted to better understand the properties associated with the metabolic brain network in mild cognitive impairment (MCI) and Alzheimer's disease (AD). Graph theory was employed to investigate the topological organization of metabolic brain network among 86 patients with MCI, 89 patients with AD, and 97 normal controls (NCs) using 18F fluoro-deoxy-glucose positron emission tomography (FDG-PET) data. The whole brain was divided into 82 areas by Brodmann atlas to construct networks. We found that MCI and AD showed a loss of small-world properties and topological aberrations, and MCI showed an intermediate measurement between NC and AD...
January 1, 2017: American Journal of Alzheimer's Disease and Other Dementias
https://www.readbyqxmd.com/read/28930979/analysis-of-18fdg-pet-ct-imaging-as-a-tool-for-studying-mycobacterium-tuberculosis-infection-and-treatment-in-non-human-primates
#19
Alexander G White, Pauline Maiello, M Teresa Coleman, Jaime A Tomko, L James Frye, Charles A Scanga, Philana Ling Lin, JoAnne L Flynn
Mycobacterium tuberculosis remains the number one infectious agent in the world today. With the emergence of antibiotic resistant strains, new clinically relevant methods are needed that evaluate the disease process and screen for potential antibiotic and vaccine treatments. Positron Emission Tomography/Computed Tomography (PET/CT) has been established as a valuable tool for studying a number of afflictions such as cancer, Alzheimer's disease, and inflammation/infection. Outlined here are a number of strategies that have been employed to evaluate PET/CT images in cynomolgus macaques that are infected intrabronchially with low doses of M...
September 5, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28930828/18f-fdg-pet-ct-in-preoperative-staging-of-vulvar-cancer-patients-is-it-really-effective
#20
Cinzia Crivellaro, Priscilla Guglielmo, Elena De Ponti, Federica Elisei, Luca Guerra, Sonia Magni, Maria La Manna, Giampaolo Di Martino, Claudio Landoni, Alessandro Buda
The aim of this study was to assess the role of 18F-FDG PET/CT in preoperative staging of vulvar cancer patients.29 pts (69 years, range 51-88) with vulvar cancer (clinical apparent stage I-II), underwent preoperative FDG-PET/CT scan followed by radical vulvectomy and bilateral (or monolateral in case of tumor >2 cm from midline) inguinal lymphadenectomy ± sentinel node biopsy. PET/CT images were analyzed in consensus and correlated to histological findings according to a pt-based and a groin-based analyses...
September 2017: Medicine (Baltimore)
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