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https://www.readbyqxmd.com/read/29166756/use-of-imaging-techniques-in-large-vessel-vasculitis-and-related-conditions
#1
Annibale Versari, Nicolò Pipitone, Massimiliano Casali, Francois Jamar, Giulia Pazzola
Giant Cell Arteritis (GCA) and Takayasu's arteritis (TA) are large vessel vasculitis (LVV) primarily affecting the aorta and its major branches, mainly differentiated by the onset age (>50 years GCA and <40 years TA). In addition, temporal artery involvement and polymyalgia rheumatic are typical features of GCA, but not TA. Imaging techniques are required to secure the diagnosis of large-vessel vasculitides, and to monitor the disease course. Both morphological and metabolic imaging are involved. Morphological imaging is represented mainly by Computerized Tomography (CT), CT angiography, Magnetic Resonance (MR), MR angiography, Color-Doppler Sonography (CDS) and high-resolution CDS...
November 22, 2017: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29166753/interventional-locoregional-treatment-and-metabolic-response-advantages-of-using-pet-ct-in-the-evaluation-of-response-to-treatment
#2
Monica Finessi, Marilena Bellò, Francesca P Giunta, Andrea Veltri, Désirée Deandreis
INTRODUCTION: Interventional oncology locoregional therapies are validated treatment modalities for primary and secondary tumors in liver, lung, kidney and bone. At this time, there is no accordance in the choice of imaging modality to assess treatment response. Morphological imaging and RECIST 1.1 criteria based on size variation are limited by several critical points. On the other hand the role of functional imaging, in particular by [18F]-fluorodeoxyglucose ([18F]-FDG) positron emission tomography (PET), in both staging and response evaluation of locoregional treatments remains unclear because of the heterogeneous nature of available data...
November 22, 2017: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29166751/is-there-a-glucose-metabolic-signature-of-spreading-tdp-43-pathology-in-amyotrophic-lateral-sclerosis
#3
Donatienne van Weehaeghe, Jenny Ceccarini, Stefanie M Willekens, Joke de Vocht, Philip van Damme, Koen van Laere
BACKGROUND: Recently, four neuropathological stages of amyotrophic lateral sclerosis (ALS) with spreading of transactive response DNA-Binding Protein-43 pathology were described. Although 18F-FDG PET has been useful in diagnosis and prognosis of ALS patients, in vivo disease staging using glucose metabolic patterns across the different ALS stages have not been attempted so far. In this study, we investigated whether the discriminant brain regions of the neuropathological stage model can be translated to metabolic patterns for in vivo staging of ALS...
November 22, 2017: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29166452/is-the-18f-fdg-pet-ct-the-definite-resource-to-detect-the-recurrence-on-high-risk-thyroid-cancer-patients
#4
EDITORIAL
Carlos Alberto Buchpiguel
No abstract text is available yet for this article.
October 2017: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29166335/multiple-hypermetabolic-subcutaneous-lesions-from-hidradenitis-suppurativa-mimicking-metastases-on-18f-fdg-pet-ct
#5
Philip Asamoah, Daniel J Wale, Benjamin L Viglianti, Ka Kit Wong, Milton Gross
Hidradenitis suppurativa is an inflammatory disease associated with subcutaneous nodules/abscesses that occur commonly in the axillary, inguinal, and perineal regions. We describe a case of a 64-year-old man presenting for F-FDG PET/CT for staging of a left vocal cord squamous cell carcinoma. The scan showed uptake in the left vocal cord malignancy and multiple hypermetabolic subcutaneous foci in the right axilla, right buttocks, and scalp in known locations of skin lesions related to hidradenitis suppurativa...
November 22, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29166334/gastrointestinal-stromal-tumor-of-the-prostate-staging-and-evaluation-of-response-to-therapy-with-18f-fdg-pet-ct
#6
Yazan Z Alabed
A 49-year-old man presented for routine general physical examination was found with an enlarged prostate gland without associated symptoms. Ultrasound followed by computed tomography (CT) of abdomen and pelvis confirmed a markedly enlarged heterogeneous prostate gland. Subsequently, a staging flourine-18 fluorodeoxyglucose (F-FDG) positron emission tomography (PET/CT) scan revealed intensely FDG-avid mass involving the prostate, which was biopsied as gastrointestinal stromal tumor (GIST). The patient was treated with imatinib and a follow-up PET/CT scan showed complete metabolic response...
November 22, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29166332/testicular-estrogen-secreting-leydig-cell-tumor-in-18f-fdg-pet-ct-an-incidental-detection-in-a-patient-treated-by-chemotherapy-for-hodgkin-lymphoma
#7
Axel Van Der Gucht, Zaher Maged, Rodolfo Burruni, Jean-Luc Barras, Niklaus Schaefer
We present images of a 50-year-old man who referred for treatment of a classic Hodgkin lymphoma. While F-FDG PET/CT demonstrated a complete metabolic remission after chemotherapy, an increased F-FDG uptake of a right testicular lesion in F-FDG PET/CT and an unexplained bilateral gynecomastia were observed. A benign Leydig cell tumor was histopathologically proved after a right radical orchiectomy. The serum estradiol level was abnormally elevated reflecting the estrogen-secreting profile. This report highlights that a focal F-FDG uptake in the testicular region with unexplained gynecomastia should suggest the diagnosis of an estrogen-secreting Leydig cell tumor on F-FDG PET/CT...
November 22, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29166329/pseudolesions-impersonating-osseous-tumor-involvement-on-both-contrast-enhanced-ct-and-fdg-pet-ct
#8
Jessica K Peterson, Rustain L Morgan, Joseph S Donald, Mark A Perry
A 27-year-old man with stage IV-B Hodgkin's lymphoma status post autologous peripheral stem cell transplant in 2015 with complete response, presented in 2017 with increasing back pain. Restaging contrast enhanced CT demonstrated left brachiocephalic vein occlusion with peripheral nodular high density areas within C7-T2 vertebral bodies with corresponding radiotracer uptake on same day PET/CT. No matching lesion was seen on noncontrast CT. Findings were consistent with pooling of contrast and radiotracer within vertebral venous plexus collaterals at the cervicothoracic junction secondary to brachiocephalic vein occlusion...
November 22, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29166328/18f-fdg-pet-ct-imaging-of-hidradenocarcinoma-arising-from-preexisting-hidradenoma-of-the-knee
#9
Tirth V Patel, Jorge Oldan
Malignant tumors of the sweat glands are exceedingly rare and aggressive tumors. We present here a case of a 60-year-old man with a malignant hidradenocarcinoma that developed in a background of preexisting benign hidradenoma on the lateral aspect of the knee that was initially resected, but rapidly recurred with associated inguinal lymphadenopathy. F-FDG PET/CT was performed as part of preoperative staging, which demonstrated abnormal inguinal lymph nodes and metastatic disease to the lungs. FDG PET/CT can play an invaluable role in the initial staging and follow-up of this rare malignancy...
November 22, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29164423/successful-radical-surgical-resection-of-initially-unresectable-intrahepatic-cholangiocarcinoma-by-downsizing-chemotherapy-with-gemcitabine-plus-cisplatin-a-case-report
#10
Ryosuke Takayanagi, Shigetsugu Takano, Kensuke Sugiura, Hideyuki Yoshitomi, Katsunori Furukawa, Tsukasa Takayashiki, Satoshi Kuboki, Atsushi Kato, Masaru Miyazaki, Masayuki Ohtsuka
BACKGROUND: Intrahepatic cholangiocarcinoma (ICC) is a subtype of biliary tract cancer (BTC). Recently, downsizing chemotherapy has been applied to initially unresectable BTCs, including ICC. CASE PRESENTATION: We report a case of liver resection in a 23-year-old woman who was diagnosed with initially unresectable ICC attached to the inferior vena cava, with portal vein (PV) cavernous transformation. Positron emission tomography (PET) showed fluorodeoxyglucose (FDG) uptake in the para-aortic lymph nodes...
November 21, 2017: Surgical Case Reports
https://www.readbyqxmd.com/read/29164301/changes-in-multimodality-functional-imaging-parameters-early-during-chemoradiation-predict-treatment-response-in-patients-with-locally-advanced-head-and-neck-cancer
#11
Kee H Wong, Rafal Panek, Alex Dunlop, Dualta Mcquaid, Angela Riddell, Liam C Welsh, Iain Murray, Dow-Mu Koh, Martin O Leach, Shreerang A Bhide, Christopher M Nutting, Wim J Oyen, Kevin J Harrington, Kate L Newbold
OBJECTIVE: To assess the optimal timing and predictive value of early intra-treatment changes in multimodality functional and molecular imaging (FMI) parameters as biomarkers for clinical remission in patients receiving chemoradiation for head and neck squamous cell carcinoma (HNSCC). METHODS: Thirty-five patients with stage III-IVb (AJCC 7th edition) HNSCC prospectively underwent (18)F-FDG-PET/CT, and diffusion-weighted (DW), dynamic contrast-enhanced (DCE) and susceptibility-weighted MRI at baseline, week 1 and week 2 of chemoradiation...
November 21, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29164299/comparison-of-18-f-fdg-pet-mri-and-mri-alone-for-whole-body-staging-and-potential-impact-on-therapeutic-management-of-women-with-suspected-recurrent-pelvic-cancer-a-follow-up-study
#12
Lino M Sawicki, Julian Kirchner, Johannes Grueneisen, Verena Ruhlmann, Bahriye Aktas, Benedikt M Schaarschmidt, Michael Forsting, Ken Herrmann, Gerald Antoch, Lale Umutlu
PURPOSE: To evaluate the diagnostic performance of (18)F-FDG PET/MRI for whole-body staging and potential changes in therapeutic management of women with suspected recurrent pelvic cancer in comparison with MRI alone. METHODS: Seventy-one consecutive women (54 ± 13 years, range: 25-80 years) with suspected recurrence of cervical (32), ovarian (26), endometrial (7), vulvar (4), and vaginal (2) cancer underwent PET/MRI including a diagnostic contrast-enhanced MRI protocol...
November 21, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29164298/value-of-18-f-fdg-pet-ct-for-predicting-egfr-mutations-and-positive-alk-expression-in-patients-with-non-small-cell-lung-cancer-a-retrospective-analysis-of-849-chinese-patients
#13
Zhilei Lv, Jinshuo Fan, Juanjuan Xu, Feng Wu, Qi Huang, Mengfei Guo, Tingting Liao, Shuqing Liu, Xiaoli Lan, Shanshan Liao, Wei Geng, Yang Jin
PURPOSE: Epidermal growth factor receptor (EGFR) mutations and the anaplastic lymphoma kinase (ALK) rearrangement are the two most common druggable targets in non-small cell lung cancer (NSCLC). However, genetic testing is sometimes unavailable. Previous studies regarding the predictive role of (18)F-FDG PET/CT for EGFR mutations in NSCLC patients are conflicting. We investigated whether or not (18)F-FDG PET could be a valuable noninvasive method to predict EGFR mutations and ALK positivity in NSCLC using the largest patient cohort to date...
November 21, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29164208/-unknown-title
#14
Jia Wang, Philip H Chao, Sebastian Hanet, R Michael van Dam
Despite the increasing importance of positron emission tomography (PET) imaging in research and clinical management of disease, access to myriad new radioactive tracers is severely limited due to their short half-lives (which requires daily production) and the high cost and complexity of tracer production. The application of droplet microfluidics based on electrowetting-on-dielectric (EWOD) to the field of radiochemistry can significantly reduce the amount of radiation shielding necessary for safety and the amount of precursor and other reagents needed for the synthesis...
November 22, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/29164057/diagnostic-and-prognostic-significance-of-methionine-uptake-and-methionine-positron-emission-tomography-imaging-in-gliomas
#15
REVIEW
Kamalakannan Palanichamy, Arnab Chakravarti
The present most common image diagnostic tracer in clinical practice for glioma is (18)F-fluorodeoxyglucose (FDG) positron emission tomography (PET) for brain tumors diagnosis and prognosis. PET is a promising molecular imaging technique, which provides real-time information on the metabolic behavior of the tracer. The diffusive nature of glioblastoma (GBM) and heterogeneity often make the radiographic detection by FDG-PET inaccurate, and there is no gold standard. FDG-PET often leads to several controversies in making clinical decisions due to their uptake by normal surrounding tissues, and pose a challenge in delineating treatment-induced necrosis, edema, inflammation, and pseudoprogression...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/29164005/study-of-systemic-disease-igg4-usefulness-of-2-18f-fluoro-2-deoxy-d-glucose-positron-emission-tomography-computed-tomography-for-staging-selection-of-biopsy-site-evaluation-of-treatment-response-and-follow-up
#16
Guillermo Martinez-Pimienta, Edel Noriega-Álvarez, Marc Simó-Perdigó
Immunoglobulin G4-related systemic disease (IgG4-RSD) is a recently emerging disorder characterized by swelling lesions with storiform fibrosis and lymphoplasmacytic infiltration enriched with IgG4-positive plasma cells. IgG4-RSD has been found in multiple organs/tissues. The diagnosis requires the integration of clinical, serological, imaging, histopathological, and immunohistological features. The 2-[18F]-fluoro-2-deoxy-D-glucose-positron emission tomography/computed tomography (18F-FDG PET/CT) enables the acquisition of whole-body images and provides functional information about disease activity...
September 2017: European Journal of Rheumatology
https://www.readbyqxmd.com/read/29163839/prognostic-value-of-intratumoral-metabolic-heterogeneity-on-f-18-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-in-locally-advanced-cervical-cancer-patients-treated-with-concurrent-chemoradiotherapy
#17
Gun Oh Chong, Won Kee Lee, Shin Young Jeong, Shin-Hyung Park, Yoon Hee Lee, Sang-Woo Lee, Dae Gy Hong, Jae-Chul Kim, Yoon Soon Lee
Objective: To evaluate the prognostic value for predicting tumor recurrence of intratumoral metabolic heterogeneity and traditional quantitative metabolic parameters on pre-treatment F-18-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) in patients with locally advanced cervical cancer treated with concurrent chemoradiotherapy (CCRT). Materials and Methods: Ninety-three patients with biopsy-proven cervical cancer and treated with CCRT (FIGO stage IIB-IV) were enrolled in this study...
October 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/29163237/-18f-fluorodeoxyglucose-positron-emission-tomography-in-rats-with-prolonged-cocaine-self-administration-suggests-potential-brain-biomarkers-for-addictive-behavior
#18
Nazzareno Cannella, Alejandro Cosa-Linan, Mareike Roscher, Tatiane T Takahashi, Nils Vogler, Björn Wängler, Rainer Spanagel
The DSM5-based dimensional diagnostic approach defines substance use disorders on a continuum from recreational drug use to habitual and ultimately addicted behavior. Biomarkers that are indicative of recreational drug use and addicted behavior are lacking. We performed a translational [18F]-fluorodeoxyglucose-positron emission tomography (FDG-PET) study in the multi-dimensional 0/3crit model of cocaine addiction. Addict-like (3crit) and non-addict-like (0crit) rats, which shared identical life conditions and levels of cocaine self-administration, were acquired for FDG-PET under baseline conditions and following cocaine and yohimbine challenges...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29163207/a-new-personalized-cooling-protocol-to-activate-brown-adipose-tissue-in-young-adults
#19
Borja Martinez-Tellez, Guillermo Sanchez-Delgado, Yolanda Garcia-Rivero, Juan M A Alcantara, Wendy D Martinez-Avila, Maria V Muñoz-Hernandez, Josune Olza, Mariëtte R Boon, Patrick C N Rensen, Jose M Llamas-Elvira, Jonatan R Ruiz
Brown adipose tissue (BAT) activity is induced when humans are exposed to cold. Therefore, cold exposure prior to the (18)F-FDG-PET/CT scan is used as a tool to quantify BAT. Several cooling protocols, including fixed and personalized ones are currently in use. The aim of the present study was to determine the effect of a new personalized cooling protocol where the shivering threshold was measured on a separate day, on BAT volume and activity in young adults. A total of 47 adults (n = 28 women) aged 22 ± 2 years participated in the study...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29162527/usefulness-of-fdg-pet-in-comparison-with-methionine-pet-in-differentiating-solid-hemangioblastoma-from-adult-cerebellar-tumors
#20
Yoshinobu Takahashi, Akimasa Nishio, Daisuke Yamamoto, Hajime Kamada, Naoya Hashimoto
BACK GROUND AND PURPOSE: Among adults with posterior fossa tumors, intraaxial location of the tumors is less common than extraaxial. Moreover, the differential diagnosis of a single cerebellar tumor in adult is sometimes difficult by conventional MRI. We aimed to report the findings of PET using FDG and methionine in adult patients with intraaxial and solitary metastatic brain tumors. MATERIALS AND METHODS: FDG-PET was performed on 12 patients with posterior fossa tumors: four had solid hemangioblastoma (HB), three had primary central nervous system lymphomas, one had a glioblastoma, and four had single metastatic brain tumors (METs)...
November 18, 2017: World Neurosurgery
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