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https://www.readbyqxmd.com/read/28870646/psychopathological-dimensions-and-the-clinician-s-subjective-experience
#1
Angelo Picardi, Mauro Pallagrosi, Laura Fonzi, Massimo Biondi
Classical psychopathology highly valued the interaction between clinician and patient, and recent findings have provided preliminary evidence of an association between categorical psychiatric diagnosis and the clinician's subjective experience during the first clinical assessment. To extend these findings, the present study examined the relationship between psychopathological dimensions and clinicians' subjective experiences. The study involved 45 clinicians and 783 patients in several psychiatric inpatient and outpatient units...
August 30, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28845167/validation-of-the-korean-version-of-the-clinical-assessment-interview-for-negative-symptoms
#2
Seon-Kyeong Jang, Seon-Cheol Park, Kee-Hong Choi, Jung-Seo Yi, Joong-Kyu Park, Jung Suk Lee, Seung-Hwan Lee
OBJECTIVE: Clinical Assessment Interview for Negative Symptoms (CAINS) has recently been developed to improve measurement of negative symptoms in schizophrenia. We performed a multi-center study to validate the Korean version of the CAINS (CAINS-K) and explore potential cultural variation. METHODS: One hundred eighty schizophrenia patients diverse in demographic and illness profile were recruited from four centers in Korea. Along with the CAINS-K, the Scale for the Assessment of Negative Symptoms (SANS), Brief Psychiatric Rating Scale (BPRS), Calgary Depression Scale for Schizophrenia (CDSS), a self-report measure of behavioral inhibition and activation (BIS/BAS) and neurocognitive tasks were administered to verify external validities...
July 2017: Psychiatry Investigation
https://www.readbyqxmd.com/read/28844639/rapid-vs-slow-antipsychotic-initiation-in-schizophrenia-a-systematic-review-and-meta-analysis
#3
Hiroyoshi Takeuchi, Sadhana Thiyanavadivel, Ofer Agid, Gary Remington
BACKGROUND: How antipsychotics should be initiated/titrated in patients with acute schizophrenia as well as patients undergoing an antipsychotic switch remains a question. METHODS: MEDLINE, Embase, and Cochrane Central Register of Controlled Trials were systematically searched. Randomized controlled trials examining rapid vs. slow antipsychotic initiation in patients with schizophrenia were selected. Data on study discontinuation, psychopathology, extrapyramidal symptoms (EPS), and treatment-emergent adverse events (TEAEs) were extracted and synthesized in studies including clinically different populations of acute patients and stable patients undergoing an antipsychotic switch...
August 22, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28841275/neuropsychiatric-manifestations-of-pediatric-nmda-receptor-autoimmune-encephalitis-a-case-series-from-a-tertiary-care-center-in-india
#4
Salah Basheer, Madhu Nagappa, Anita Mahadevan, Parayil Sankaran Bindu, Arun B Taly, Satish Chandra Girimaji
Objective: Although psychiatric manifestations are one of the most common presentations of pediatric N-methyl-D-aspartate receptor (NMDAR) encephalitis, there is a lack of studies that characterize psychiatric aspects of this disorder. This study was designed to address this gap. Methods: Initial clinical presentations including psychiatric symptoms, treatment details, and outcome with respect to psychiatric symptoms were collected from medical case records of children aged less than 18 years with seropositive NMDAR encephalitis from a single tertiary care center (May 2010-November 2016)...
August 17, 2017: Primary Care Companion to CNS Disorders
https://www.readbyqxmd.com/read/28827867/a-factor-analytical-study-report-on-mania-from-nepal
#5
Sanjeev Shah, Tapas Kumar Aich, Sandip Subedi
BACKGROUND AND OBJECTIVES: Phenomenological studies on mood disorder are rare in Nepal which prompted us to undertake the current factor analytical study of mania. MATERIALS AND METHODS: It was a cross-sectional descriptive study for which we did purposive sampling technique according to certain inclusion and exclusion criteria. The study sample consists of fifty patients, who fulfilled the International Classification of Diseases, Tenth Edition (ICD-10) diagnostic criteria for Manic Episode and/or Bipolar Affective Disorder-current episode mania...
April 2017: Indian Journal of Psychiatry
https://www.readbyqxmd.com/read/28826267/inpatient-psychiatric-treatment-is-not-always-effective-in-adolescent-sample
#6
Barbara Remberk, Anna Katarzyna Bażyńska, Joanna Brągoszewska, Piotr Niwiński, Agnieszka Piróg-Balcerzak, Lidia Popek, Filip Rybakowski
OBJECTIVE: Numerous studies confirm efficacy of psychiatric treatment as well as psychiatric placebo. The aim of the current study was the assessment of improvement rate and factors associated with treatment response in naturalistic group of adolescent inpatients. METHODS: Eighty two consecutive adolescent inpatients were recruited. Each patient at the admission and discharge was assessed with brief psychiatric rating scale (BPRS), eating attitude test (EAT-26), clinical global impression scale (CGI-S) and children global assessment scale (CGAS)...
August 21, 2017: International Journal of Psychiatry in Clinical Practice
https://www.readbyqxmd.com/read/28802523/development-of-a-split-flow-system-for-high-precision-variable-sample-introduction-in-supercritical-fluid-chromatography
#7
Miho Sakai, Yoshihiro Hayakawa, Yasuhiro Funada, Takashi Ando, Eiichiro Fukusaki, Takeshi Bamba
In this study, we propose a novel variable sample injection system based on full-loop injection, named the split-flow sample introduction system, for application in supercritical fluid chromatography (SFC). In this system, the mobile phase is split by the differential pressure between two back pressure regulators (BPRs) after full-loop injection suitable for SFC, and this differential pressure determines the introduction rate. Nine compounds with a wide range of characteristics were introduced with high reproducibility and universality, confirming that a robust variable sample injection system was achieved...
July 25, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28800334/baseline-predictors-of-antipsychotic-treatment-continuation-and-response-at-week-8-in-patients-with-alzheimer-s-disease-with-psychosis-or-aggressive-symptoms-an-analysis-of-the-catie-ad-study
#8
Tomoyuki Nagata, Shinichiro Nakajima, Shunichiro Shinagawa, Eric Plitman, Kazuhiko Nakayama, Ariel Graff-Guerrero, Masaru Mimura
BACKGROUND/OBJECTIVE: The aim of the present study was to investigate predictors of atypical antipsychotic (AAP) treatment continuation and response by week 8 in patients with Alzheimer's disease (AD) who have psychotic/aggressive symptoms using the Clinical Antipsychotic Trials of Intervention Effectiveness-Alzheimer's Disease (CATIE-AD) dataset. METHODS: Clinical data was utilized from 421 AD outpatients with psychotic/aggressive symptoms who needed interventional treatment...
August 9, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28783576/association-of-serum-bdnf-levels-with-psychotic-symptom-in-chronic-patients-with-treatment-resistant-depression-in-a-chinese-han-population
#9
Xingbing Huang, Xiong Huang, Yanling Zhou, Hongbo He, Fang Mei, Bin Sun, Jair C Soares, Xiang Yang Zhang
The neurotrophic hypothesis of depression is supported by consistent findings of lower serum BDNF levels in depressed patients. Increasing evidence shows different clinical characteristics of patients with psychotic major depression versus nonpsychotic major depression. However, the possible association between BDNF and psychotic symptoms in depression has not been investigated. We recruited 90 treatment-resistant depression (TRD) patients and 90 gender- and age-matched healthy control subjects and examined serum BDNF in both groups...
July 31, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28748850/correlation-between-electroencephalogram-alterations-and-frontal-cognitive-impairment-in-esophageal-cancer-patients-complicated-with-depression
#10
Yin Cao, Xia Chen, Hui Xie, Ling Zou, Li-Jun Hu, Xian-Ju Zhou
BACKGROUND: Some esophageal cancer patients complicated with depression exhibit cognitive impairments. Frontal electroencephalogram (EEG) may be used as a reliable biomarker for prefrontal-mediated cognitive functions. This study was to investigate alterations of EEG and frontal cognitive impairment in esophageal cancer patients complicated with depression and to assess their correlation. METHODS: Sixty-five esophageal cancer patients with depression (study group) and 62 healthy controls (control group) were included in this study...
August 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28713080/clinical-and-psychopathological-characteristics-of-the-autoagressive-behavior-in-patients-with-the-first-psychotic-episode-with-considering-circadian-rhythms
#11
Dmytro I Boiko, Lilia V Zhyvotovska, Grigorij T Sonnik, Andrij M Skrypnіkov
INTRODUCTION: The high rate of autoagressive action in patients with psychotic symptoms manifested during the beginning of active psychopharmatherapy, and they are often the reason for psychiatric help. The continuous growth of autoagressive behavior indicates the number of unsolved problems in clinical suicidology. AIM: The aim of this research was to explore the clinical and psychopathological characteristics of the autoagressive behavior in patients with the first psychotic episode with considering circadian rhythms...
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28708736/mifepristone-plasma-level-and-glucocorticoid-receptor-antagonism-associated-with-response-in-patients-with-psychotic-depression
#12
Thaddeus Block, Georgios Petrides, Harvey Kushner, Ned Kalin, Joseph Belanoff, Alan Schatzberg
BACKGROUND: Psychotic depression has no Food and Drug Administration-approved treatment. Patients demonstrate significant dysregulation of the hypothalamic-pituitary-adrenal axis providing a biologically targeted treatment opportunity. The purpose of this study was to explore the clinical and biological effects of short-duration (7-day) glucocorticoid receptor antagonism with mifepristone and the role of mifepristone plasma levels in patients with psychotic depression. METHODS: This double-blind, randomized study took place at 34 US clinical research centers and included patients with a diagnosis of Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, major depressive disorder, severe, with psychotic features...
July 13, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28698921/serum-galectin-3-but-not-galectin-1-levels-are-elevated-in-schizophrenia-implications-for-the-role-of-inflammation
#13
Kosuke Kajitani, Kazuyuki Yanagimoto, Yusaku Nakabeppu
BACKGROUND: Previous studies have reported that galectin-3 is involved in inflammatory processes in the central nervous system and that neuroinflammation may play a role in the pathogenesis of schizophrenia. However, the link between schizophrenia and various galectins is unclear. OBJECTIVE: The objective of the present study is to determine whether galectin, a well-known lectin protein that binds to μ-galactoside, is associated with chronic schizophrenia. METHODS: Thirty-six patients with schizophrenia and 36 healthy controls participated in this study...
July 11, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28682596/formation-of-highly-oxidized-radicals-and-multifunctional-products-from-the-atmospheric-oxidation-of-alkylbenzenes
#14
Sainan Wang, Runrun Wu, Torsten Berndt, Mikael Ehn, Liming Wang
Aromatic hydrocarbons contribute significantly to tropospheric ozone and secondary organic aerosols (SOA). Despite large efforts in elucidating the formation mechanism of aromatic-derived SOA, current models still substantially underestimate the SOA yields when comparing to field measurements. Here we present a new, up to now undiscovered pathway for the formation of highly oxidized products from the OH-initiated oxidation of alkyl benzenes based on theoretical and experimental investigations. We propose that unimolecular H-migration followed by O2-addition, a so-called autoxidation step, can take place in bicyclic peroxy radicals (BPRs), which are important intermediates of the OH-initiated oxidation of aromatic compounds...
July 18, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28669774/how-well-do-patients-with-a-first-episode-of-schizophrenia-respond-to-antipsychotics-a-systematic-review-and-meta-analysis
#15
REVIEW
Yikang Zhu, Chunbo Li, Maximilian Huhn, Philipp Rothe, Marc Krause, Irene Bighelli, Johannes Schneider-Thoma, Stefan Leucht
It is often stated that first-episode patients tend to respond better to antipsychotics than chronic patients, but the exact numbers and moderators of response in this population are unclear. We, therefore, present the first systematic review on response rates of first episode patients with schizophrenia in randomized trials. We searched multiple databases for randomized-controlled trials of antipsychotics in acutely ill patients with a first episode of schizophrenia (last search: November 17, 2016). The outcomes were response rate based on two criteria, at least 50% PANSS or BPRS total score reduction from baseline and at least 20% reduction...
September 2017: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28641816/-association-between-the-violence-in-the-community-and-the-aggressive-behaviors-of-psychotics-during-their-hospitalizations
#16
M Rothärmel, M-F Poirier, G Levacon, F Kazour, S Bleher, D Gastal, S Lazareth, P Lebain, M Olari, R Oukebdane, C-E Rengade, J Themines, M Abbar, S Dollfus, A Gassiot, S Haouzir, D Januel, B Millet, J-P Olié, L Stamatiadis, J-L Terra, J Bénichou, D Campion, O Guillin
BACKGROUND: Violence is a common issue in psychiatry and has multiple determiners. The aim of this study is to assess the psychotic inpatients' violence in association with the violence of the neighborhood from which the patients are drawn and to estimate the impact of this environmental factor with regard to other factors. METHOD: A prospective multicenter study was led in nine French cities. Eligible patients were psychotic involuntary patients hospitalized in the cities' psychiatric wards...
June 19, 2017: L'Encéphale
https://www.readbyqxmd.com/read/28640170/effectiveness-of-electroconvulsive-therapy-and-associated-cognitive-change-in-schizophrenia-a-naturalistic-comparative-study-of-treating-schizophrenia-with-electroconvulsive-therapy
#17
Phern-Chern Tor, Jiangbo Ying, New Fei Ho, Mingyuan Wang, Donel Martin, Chai Pin Ang, Chunzhen Tan, Lee Shen Yap, Vincent John Magat Lu, Brett Simpson, Yee Ming Mok, Colleen Loo
OBJECTIVE: There is limited evidence regarding the relative treatment effectiveness and cognitive effects of different types of electroconvulsive therapy (ECT) in schizophrenia. In this study, we sought to determine the overall effectiveness and compare the symptomatic and cognitive outcomes of patients with schizophrenia who received different modalities of ECT treatment. METHODS: Patients received 1 of 4 of the following ECT modalities: bitemporal ECT with age-based dosing, right unilateral ECT with seizure threshold-based dosing, bitemporal ECT with seizure threshold-based dosing, and bifrontal ECT with seizure threshold-based dosing ECT...
June 15, 2017: Journal of ECT
https://www.readbyqxmd.com/read/28613973/the-association-of-cannabis-use-on-inpatient-psychiatric-hospital-outcomes
#18
Melanie Rylander, Helena R Winston, Haley Medlin, Madelyne Hull, Abraham Nussbaum
BACKGROUND: The associations between cannabis use and psychosis are well documented in numerous studies. There is a need to evaluate the impact of cannabis use on inpatient psychiatric utilization and outcomes. OBJECTIVES: To evaluate the impact of cannabis use on psychiatric hospital outcomes. METHODS: This study was conducted between April 20, 2015 and October 20, 2015. All patients (n = 120) admitted to Denver Health with psychotic symptoms were administered a urine toxicology screening testing for the presence of 11-nor-9-carboxy-Δ(9)-tetrahydrocannabinol (THC-COOH, the active metabolite of cannabis)...
June 14, 2017: American Journal of Drug and Alcohol Abuse
https://www.readbyqxmd.com/read/28613395/clozapine-dose-for-schizophrenia
#19
REVIEW
Selvizhi Subramanian, Birgit A Völlm, Nick Huband
BACKGROUND: Schizophrenia and related disorders such as schizophreniform and schizoaffective disorder are serious mental illnesses characterised by profound disruptions in thinking and speech, emotional processes, behaviour and sense of self. Clozapine is useful in the treatment of schizophrenia and related disorders, particularly when other antipsychotic medications have failed. It improves positive symptoms (such as delusions and hallucinations) and negative symptoms (such as withdrawal and poverty of speech)...
June 14, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28605626/factor-structure-of-the-brief-psychiatric-rating-scale-expanded-bprs-e-in-a-large-hospitalized-sample
#20
Alan Shafer, Federico Dazzi, Joseph Ventura
Meta-analytically derived models of the BPRS-E factor structure were tested on a large (n = 33,903) hospitalized sample using confirmatory factor analysis. A modified four factor model (Positive symptoms, Negative symptoms, Affect, and Activation) containing 12 core BPRS-E symptoms based on the meta-analytic models had excellent model fit. An additional five factor, 15 core symptom model, which added a Disorganization factor consistent with the pentagonal model of schizophrenic symptoms also had support with generally good fit...
October 2017: Journal of Psychiatric Research
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