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https://www.readbyqxmd.com/read/27910162/effects-of-sample-size-and-distributional-assumptions-on-competing-models-of-the-factor-structure-of-the-panss-and-bprs
#1
Stephen J Tueller, Kiersten L Johnson, Kevin J Grimm, Sarah L Desmarais, Brian G Sellers, Richard A Van Dorn
Factor analytic work on the Positive and Negative Syndrome Scale (PANSS) and Brief Psychiatric Rating Scale (BPRS) has yielded varied and conflicting results. The current study explored potential causes of these discrepancies. Prior research has been limited by small sample sizes and an incorrect assumption that the items are normally distributed when in practice responses are highly skewed ordinal variables. Using simulation methodology, we examined the effects of sample size, (in)correctly specifying item distributions, collapsing rarely endorsed response categories, and four factor analytic models...
December 2, 2016: International Journal of Methods in Psychiatric Research
https://www.readbyqxmd.com/read/27893018/effect-of-%C3%AF-3-polyunsaturated-fatty-acids-in-young-people-at-ultrahigh-risk-for-psychotic-disorders-the-neurapro-randomized-clinical-trial
#2
Patrick D McGorry, Barnaby Nelson, Connie Markulev, Hok Pan Yuen, Miriam R Schäfer, Nilufar Mossaheb, Monika Schlögelhofer, Stephan Smesny, Ian B Hickie, Gregor Emanuel Berger, Eric Y H Chen, Lieuwe de Haan, Dorien H Nieman, Merete Nordentoft, Anita Riecher-Rössler, Swapna Verma, Andrew Thompson, Alison Ruth Yung, G Paul Amminger
Importance: A promising treatment to prevent onset and improve outcomes in patients at ultrahigh risk for psychosis is dietary supplementation with long-chain ω-3 polyunsaturated fatty acids (PUFAs). Objective: To determine whether treatment with ω-3 PUFAs in combination with a high-quality psychosocial intervention (cognitive behavioral case management [CBCM]) is more effective than placebo plus CBCM. Design, Setting, and Participants: NEURAPRO, a double-blind, placebo-controlled, randomized clinical trial, was conducted from March 1, 2010, to September 30, 2014, in 10 specialized early psychosis treatment services in Australia, Asia, and Europe...
November 23, 2016: JAMA Psychiatry
https://www.readbyqxmd.com/read/27879426/the-successful-concurrent-use-of-two-long-acting-depot-antipsychotics-in-a-patient-with-treatment-resistant-schizophrenia-and-history-of-serious-violence-a-case-report
#3
Anna Lenardon, Mona Ahmed, Katie-Lynn Harfield, Mrigendra Das
OBJECTIVE: This case report describes a forensic psychiatric patient presenting with treatment-resistant schizophrenia and serious interpersonal violence complicated by poor adherence to oral medication who was treated successfully with two concurrent long-acting depot antipsychotics. METHOD: Treatment response was measured for a 6-month period at 6-weekly intervals, post-initiation using the Positive and Negative Symptoms of Schizophrenia with Excited Component score (PANSS-EC), Brief Psychiatric Rating Scale (BPRS) and Clinical Global Impression Scale (CGI)...
November 22, 2016: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
https://www.readbyqxmd.com/read/27837572/clinical-and-cognitive-factors-affecting-psychosocial-functioning-in-remitted-patients-with-bipolar-disorder
#4
G Konstantakopoulos, N Ioannidi, M Typaldou, D Sakkas, P Oulis
Impaired interpersonal, social, and occupational functioning is very often observed in patients with bipolar disorder, not only at the acute stages of the illness but in remission as well. This finding raises the question of multiple factors that might affect psychosocial functioning in bipolar patients, such as residual subsyndromal symptoms and neuropsychological deficits. Social cognition impairment, especially impaired Theory of Mind (ToM), might also play an important role in bipolar patients' every-day functioning, similarly to what was found in patients with schizophrenia...
July 2016: Psychiatrikē, Psychiatriki
https://www.readbyqxmd.com/read/27835719/adjunctive-taurine-in-first-episode-psychosis-a-phase-2-double-blind-randomized-placebo-controlled-study
#5
Colin P O'Donnell, Kelly A Allott, Brendan P Murphy, Hok Pan Yuen, Tina-Marie Proffitt, Alicia Papas, Jennifer Moral, Tee Pham, Michaela K O'Regan, Christina Phassouliotis, Raelene Simpson, Patrick D McGorry
OBJECTIVE: Taurine is an inhibitory neuromodulatory amino acid in the central nervous system that activates the GABA- and glycine-insensitive chloride channel and inhibits the N-methyl-d-aspartate receptor. It also functions as a neuroprotective agent and has a role in neural development and neurogenesis. The aim of this study was to determine the efficacy of adjunctive taurine in improving symptomatology and cognition among patients with a DSM-IV first-episode psychotic disorder. METHODS: 121 patients with first-episode psychosis, aged 18-25 years, attending early intervention services consented to participate in this randomized, double-blind, placebo-controlled trial conducted from January 2007 to May 2009...
November 8, 2016: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/27833222/a-study-of-soft-neurological-signs-and-its-correlates-in-drug-naive-patients-with-first-episode-psychosis
#6
Vanishree Gunasekaran, V Mathan Kumar Venkatesh, T V Asokan
BACKGROUND: Soft neurological signs are minor, non localizing, objective abnormalities, thought to reflect damage in cortical and sub-cortical connections or connections within different cortical regions. Regional structural grey matter anomalies have already been observed and correlated with the presence of cognitive deficits and presence of soft neurological signs in schizophrenic patients. MATERIALS AND METHODS: Drug naive patients presenting with first episode of psychosis (FEP)were clinically evaluated for soft neurological signs using the Cambridge Neurological Inventory...
September 2016: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/27809822/primary-psychosis-and-borna-disease-virus-infection-in-lithuania-a-case-control-study
#7
Violeta Zaliunaite, Vesta Steibliene, Liv Bode, Aurelija Podlipskyte, Robertas Bunevicius, Hanns Ludwig
BACKGROUND: The hypothesis that microbial infections may be linked to mental disorders has long been addressed for Borna disease virus (BDV), but clinical and epidemiological evidence remained inconsistent due to non-conformities in detection methods. BDV circulating immune complexes (CIC) were shown to exceed the prevalence of serum antibodies alone and to comparably screen for infection in Europe (DE, CZ, IT), the Middle East (IR) and Asia (CN), still seeking general acceptance. METHODS: We used CIC and antigen (Ag) tests to investigate BDV infection in Lithuania through a case-control study design comparing in-patients suffering of primary psychosis with blood donors...
November 3, 2016: BMC Psychiatry
https://www.readbyqxmd.com/read/27776390/amisulpride-switching-in-schizophrenic-patients-who-showed-suboptimal-effect-and-or-tolerability-to-current-antipsychotics-in-a-naturalistic-setting-an-explorative-study
#8
Yongmin Kim, Sheng-Min Wang, Kyung-Phil Kwak, Ho-Kyoung Yoon, Chi-Un Pae, Jung-Jin Kim, Won-Myong Bahk
Objective: Despite numerous atypical antipsychotics (AAP) available, many patients with schizophrenia still experience lack of efficacy and persistent side-effects. Switching from one AAP to another with a different side-effect profile has become a common clinical strategy. We aimed to investigate effect of switching to amisulpride in patients who showed suboptimal effect and /or tolerability to current antipsychotics treatment. Methods: This was a 6-week, prospective, multicenter, open-label, flexible-dose study in patients with schizophrenia...
November 30, 2016: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27770713/facial-emotion-recognition-and-alexithymia-in-chinese-male-patients-with-deficit-schizophrenia
#9
Xiao Wei Tang, Miao Yu, Wei Wei Duan, Xiang Rong Zhang, Wei Wei Sha, Xiang Wang, Xiao Bin Zhang
Deficit schizophrenia (DS) has been proposed as a pathophysiologically distinct schizophrenia subtype. This study investigated facial emotion recognition deficits and alexithymia in DS and non-deficit schizophrenia patients (NDS) and their relationships with other clinical variables. The Brief Psychiatric Rating Scale (BPRS), Scale for the Assessment of Negative Symptoms (SANS), and Scale for the Assessment of Positive Symptoms (SAPS) were employed to evaluate the psychiatric symptoms in patients with schizophrenia...
September 29, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/27711937/il-4-tgf-%C3%AF-nf-%C3%AF-b-and-mpo-levels-in-patients-with-treatment-resistant-schizophrenia
#10
Şükrü Kartalcı, Lale Gönenir Erbay, Esra Porgalı Zayman, Önder Otlu, Aysun Bay Karabulut, Gülşen Kartalcı
OBJECTIVE: Schizophrenia is a chronic psychotic disorder in which genetics and environmental factors such as infection and the corresponding immune response play a role in the etiopathogenesis. The aim of this study was to compare some immune factors such as nuclear factor-B (NF-B) activation, myeloperoxidase (MPO), the anti-inflammatory cytokine interleukin-4 (IL-4), and regulatory cytokine transforming growth factor- (TGF-) in schizophrenia patients and an age- and gender-matched control group...
2016: Türk Psikiyatri Dergisi, Turkish Journal of Psychiatry
https://www.readbyqxmd.com/read/27676420/a-52-week-study-of-olanzapine-with-a-randomized-behavioral-weight-counseling-intervention-in-adolescents-with-schizophrenia-or-bipolar-i-disorder
#11
Holland C Detke, Melissa P DelBello, John Landry, Vicki Poole Hoffmann, Alexandra Heinloth, Ralf W Dittmann
OBJECTIVES: To evaluate the 52-week safety/tolerability of oral olanzapine for adolescents with schizophrenia or bipolar mania and compare effectiveness of a standard versus intense behavioral weight intervention in mitigating risk of weight gain. METHODS: Patients 13-17 years old with schizophrenia (Brief Psychiatric Rating Scale for Children [BPRS-C] total score >30; item score ≥3 for hallucinations, delusions, or peculiar fantasies) or bipolar I disorder (manic or mixed episode; Young Mania Rating Scale [YMRS] total score ≥15) received open-label olanzapine (2...
September 27, 2016: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/27663803/psychopathological-characteristics-of-patients-with-first-episode-psychosis-and-chronic-schizophrenia-a-descriptive-comparison
#12
Valentina Del Bello, Giulia Menculini, Patrizia Moretti, Alfonso Tortorella
Only few studies have compared the psychopathological features in first episode psychosis (FEP) and chronic schizophrenia (CS) patients. The aim of our study was to compare sociodemographic and clinical aspects of FEP and CS inpatients using the Positive and Negative Syndrome Scale (PANSS) and the Brief Psychiatric Rating Scale (BPRS) in order to better characterize FEP. We did not find significant socio-demographic differences between the two groups apart from age and nationality. About PANSS we found that conceptual disorganization, poor rapport and lack of insight items scores were significantly higher in patients with FEP...
September 2016: Psychiatria Danubina
https://www.readbyqxmd.com/read/27631410/plasma-levels-and-estimated-dopamine-d2-receptor-occupancy-of-long-acting-injectable-risperidone-during-maintenance-treatment-of-schizophrenia-a-3-year-follow-up-study
#13
Saeko Ikai, Takefumi Suzuki, Masaru Mimura, Hiroyuki Uchida
INTRODUCTION: Dopamine D2 receptor occupancy levels needed for the maintenance treatment of schizophrenia remain to be elucidated. We examined 3-year clinical outcomes of patients with schizophrenia who received long-acting injectable risperidone (LAI risperidone) at baseline and investigated their dopamine D2 receptor occupancy levels, estimated from plasma drug concentrations. METHODS: A chart review of 52 outpatients with schizophrenia who participated in the original cross-sectional study was conducted to examine their 3-year clinical outcomes between April and September 2015...
September 8, 2016: Psychopharmacology
https://www.readbyqxmd.com/read/27604273/development-and-validation-of-a-contextual-measure-of-functioning-for-people-living-with-severe-mental-disorders-in-rural-africa
#14
Kassahun Habtamu, Atalay Alem, Girmay Medhin, Abebaw Fekadu, Martin Prince, Charlotte Hanlon
BACKGROUND: Most measures of functioning in people with severe mental disorders (SMD) have been developed in Western societies. Many of the questions in these scales are culture-bound, fail to capture differentiation of tasks by gender and are difficult to adapt to other contexts. The aim of this study was to develop a measure of functioning for people with SMD which is contextually appropriate for a rural African setting. METHODS: A review of existing scales, a qualitative study, free listing and pile sorting exercises, and expert consensus were used to establish a pool of items...
2016: BMC Psychiatry
https://www.readbyqxmd.com/read/27573055/toxoplasma-gondii-infection-in-schizophrenia-and-associated-clinical-features
#15
Awatef Esshili, Sihem Thabet, Achraf Jemli, Fatma Trifa, Anouar Mechri, Ferid Zaafrane, Lotfi Gaha, Georg Juckel, Hamouda Babba, Besma Bel Hadj Jrad
The belief that latent toxoplasmosis is asymptomatic has been questioned, in particular due to the repeated highlighted link between the Toxoplasma gondii infection and an increased incidence of schizophrenia. However, to understand this relationship, the effect of infection with Toxoplasma gondii on the severity of schizophrenia has been poorly studied. Our work focused on comparing the prevalence of Toxoplasma infection between schizophrenic patients and healthy controls, as well as comparing the clinical features and the demographic characteristics between Toxoplasma-seronegative and Toxoplasma-seropositive patients with schizophrenia...
November 30, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/27557395/mixed-methods-analysis-of-internalized-stigma-correlates-in-poorly-adherent-individuals-with-bipolar-disorder
#16
Molly Howland, Jennifer Levin, Carol Blixen, Curtis Tatsuoka, Martha Sajatovic
BACKGROUND: Internalized stigma, which occurs when stigmatized individuals accept society's assessment and incorporate this assessment into their sense of self, is prevalent in individuals with bipolar disorder (BD). This study explored the correlates of internalized stigma in a research sample of patients with BD who were poorly adherent to their medications. METHODS: Both quantitative and qualitative analyses were performed. Scores of 115 individuals with BD on the Internalized Stigma of Mental Illness (ISMI) scale were correlated with scores on the General Self-Efficacy (GSE) Scale, Brief Psychiatric Rating Scale (BPRS), Montgomery-Asberg Depression Rating Scale (MADRS), and Young Mania Rating Scale (YMRS)...
October 2016: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/27536110/clinical-characteristics-of-synthetic-cannabinoid-induced-psychosis-in-relation-to-schizophrenia-a-single-center-cross-sectional-analysis-of-concurrently-hospitalized-patients
#17
Merih Altintas, Leman Inanc, Gamze Akcay Oruc, Selim Arpacioglu, Huseyin Gulec
BACKGROUND: This study aimed to evaluate synthetic cannabinoid (SC)-induced psychosis in terms of patient profile and clinical characteristics with reference to concurrently hospitalized schizophrenic patients. METHODS: A total of 81 male patients diagnosed with psychotic disorder induced by the use of SCs (n=50; mean (standard deviation [SD]) age: 25.9 (5.5) years) or with schizophrenia (n=31, mean (SD) age: 42.9 (11.6) years) based on the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, diagnosis criteria who were concurrently hospitalized at Erenköy Mental and Neurological Diseases Training and Research Hospital were included in this cross-sectional study...
2016: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/27529666/the-latent-structure-of-psychiatric-symptoms-across-mental-disorders-as-measured-with-the-panss-and-bprs-18
#18
Richard A Van Dorn, Sarah L Desmarais, Kevin J Grimm, Stephen J Tueller, Kiersten L Johnson, Brian G Sellers, Marvin S Swartz
Raw data were used from five studies of adults with mental illnesses (N=4,480) in an attempt to identify a psychiatric symptoms factor structure, as measured by the Positive and Negative Syndrome Scale or the Brief Psychiatric Rating Scale, that was generalizable across participant characteristics. First, the fit of four extant models was tested via confirmatory factor analysis (CFA), then exploratory factor analyses (EFA) were conducted with a 50% random sample, followed by a CFA with the remaining 50% to confirm the EFA factor structure...
November 30, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/27451107/meta-analysis-of-the-brief-psychiatric-rating-scale-expanded-bprs-e-structure-and-arguments-for-a-new-version
#19
REVIEW
Federico Dazzi, Alan Shafer, Marco Lauriola
The factor structure of the 24 item BPRS-E was examined to determine the effect of additional items on consensus scales derived primarily from the 18 item BPRS. A meta-analysis (k = 32, n = 10,084) of previous factor analyses of the BPRS-E was conducted using both a co-occurrence similarity matrix and reproduced correlations. Components generally supporting the consensus scales were found suggesting four relatively invariant subscales: Affect (defined by the core items: anxiety, guilt, depression, suicidality), Positive Symptoms (hallucinations, unusual thought content, suspiciousness, grandiosity), Negative Symptoms (blunted affect, emotional withdrawal, motor retardation) and Activation (excitement, motor hyperactivity, elevated mood, distractibility)...
October 2016: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/27450743/reducing-smoking-reduces-suicidality-among-individuals-with-psychosis-complementary-outcomes-from-a-healthy-lifestyles-intervention-study
#20
Anoop Sankaranarayanan, Vanessa Clark, Amanda Baker, Kerrin Palazzi, Terry J Lewin, Robyn Richmond, Frances J Kay-Lambkin, Sacha Filia, David Castle, Jill M Williams
This study sought to explore the impact of smoking reduction on suicidality (suicide ideation and behaviour) among people with a psychotic disorder (n=235) who participated in a randomized trial of a healthy lifestyle intervention trial. Suicidality, measured by item -4 of the Brief Psychiatric Rating Scale (BPRS) was the main variable of interest. Measures were collected by research assistants blind to treatment allocation at baseline, at 15 weeks (mid-intervention) and 12 months after baseline. Mediation analysis, adjusted for confounders, was used to determine the relationship between smoking reduction and suicidality and to explore whether this was mediated through depression...
September 30, 2016: Psychiatry Research
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