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https://www.readbyqxmd.com/read/29749607/increasing-antipsychotic-dose-versus-switching-antipsychotic-for-non-response-in-schizophrenia
#1
REVIEW
Myrto T Samara, Elisabeth Klupp, Bartosz Helfer, Philipp H Rothe, Johannes Schneider-Thoma, Stefan Leucht
BACKGROUND: Many people with schizophrenia do not respond to an initially prescribed antipsychotic drug. In such cases, one treatment strategy could be to increase the antipsychotic dose; and another strategy could be to switch to a different antipsychotic drug. OBJECTIVES: To examine the efficacy of increasing the antipsychotic dose versus switching the antipsychotic drug in the treatment of non-responsive people with schizophrenia. SEARCH METHODS: We searched the Cochrane Schizophrenia Group Trials Register (10 June 2014, 6 October 2015, and 30 March 2017)...
May 11, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29713371/association-between-uncooperativeness-and-the-glucose-metabolism-of-patients-with-chronic-behavioral-disorders-after-severe-traumatic-brain-injury-a-cross-sectional-retrospective-study
#2
Tomohiro Yamaki, Kosuke Suzuki, Yusuke Sudo, Tomihisa Niitsu, Masahiko Okai, Nobuo Oka, Masaru Odaki
Bakground: Patients with behavioral disorders following severe traumatic brain injury (sTBI) often have disorders of consciousness that make expressing their emotional distress difficult. However, no standard method for assessing the unsettled and unforeseen responses that are associated with behavioral disorders has yet to be established. Because the thalamus is known to play a role in maintaining consciousness and cognition, we used 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG-PET/CT) to examine the association between brain glucose metabolism in the thalamus and behavioral disorders...
2018: BioPsychoSocial Medicine
https://www.readbyqxmd.com/read/29695941/a-naturalistic-study-on-the-relationship-among-resilient-factors-psychiatric-symptoms-and-psychosocial-functioning-in-a-sample-of-residential-patients-with-psychosis
#3
Nicola Poloni, Daniele Zizolfi, Marta Ielmini, Roberto Pagani, Ivano Caselli, Marcello Diurni, Anna Milano, Camilla Callegari
Objective: Resilience is a multidimensional process of adaptation aimed to overcome stressful or traumatic life experiences; only in the last few years it has been considered as a personal resource in psychosis and schizophrenia. This study aimed to assess the relationship between intrapersonal and interpersonal resilience factors and schizophrenia, particularly whether and how resilience can improve the course of psychotic illness. Patients and methods: In this observational study, all patients recruited had to fulfill the following inclusion criteria: diagnosis of schizophrenia spectrum disorder ( Diagnostic and Statistical Manual of Mental Disorders-5 ); aged between 18 and 65 years; provided written informed consent; to be clinically stable (Clinical Global Impression Scale <3); history of illness ≥5 years; to be compliant with antipsychotic therapy over the last year; and regular submission to periodic monthly psychiatric visits...
2018: Psychology Research and Behavior Management
https://www.readbyqxmd.com/read/29682692/the-relationship-between-fine-particulate-matter-pm-2-5-and-schizophrenia-severity
#4
Rika Eguchi, Daisuke Onozuka, Kouji Ikeda, Kenji Kuroda, Ichiro Ieiri, Akihito Hagihara
PURPOSE: Although particulate matter (PM) is reported to affect the rate of emergency admissions for schizophrenia, no study has examined the relationship between particulate matter less than 2.5 μm in diameter (PM2.5 ) and the severity of schizophrenia. METHODS: We obtained data on patients with schizophrenia at a psychiatric hospital, and on air pollution in Sakai, Japan between Feb 1, 2013 and April 30, 2016. Multivariate logistic regression analyses were used to estimate the relationship between PM2...
April 23, 2018: International Archives of Occupational and Environmental Health
https://www.readbyqxmd.com/read/29680512/involuntary-psychiatric-hospitalization-and-its-relationship-to-psychopathology-and-aggression
#5
Pedro Henrique Canova Mosele, Guillierme Chervenski Figueira, Amadeu Antônio Bertuol Filho, José Antônio Reis Ferreira de Lima, Vitor Crestani Calegaro
The current study investigates the relationship between involuntary hospitalization, severity of psychopathology, and aggression. Adult psychiatric inpatients hospitalized from August, 2012 to January, 2013 were evaluated via the Brief Psychiatric Rating Scale (BPRS) and the Overt Aggression Scale (OAS). Individuals were compared regarding voluntariness of hospitalization. Of the 137 hospitalizations in the period, 71 were involuntary (INV). The variables associated with involuntariness were being brought to hospital by ambulance or police, and aggression in the first 24 h of admission...
April 12, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29675276/effect-of-olanzapine-on-clinical-and-polysomnography-profiles-in-patients-with-schizophrenia
#6
Mohammad Zia Ul Haq Katshu, Sukanto Sarkar, S Haque Nizamie
Acute and short-term administration of olanzapine has a favorable effect on sleep in schizophrenia patients. This study aimed to clarify the effect of olanzapine on polysomnographic profiles of schizophrenia patients during the acute phase of illness after controlling for previous drug exposure. Twenty-five drug-naïve or drug-free schizophrenia patients were assessed at baseline and after six weeks of olanzapine treatment on Brief Psychiatric Rating Scale (BPRS), Positive and Negative Syndrome Scale (PANSS), and Udvalg for Kliniske Undersogelser (UKU) side-effect rating scale and a whole-night polysomnography; fifteen patients completed the study...
2018: Schizophrenia Research and Treatment
https://www.readbyqxmd.com/read/29674982/delusional-themes-across-affective-and-non-affective-psychoses
#7
Angelo Picardi, Laura Fonzi, Mauro Pallagrosi, Antonella Gigantesco, Massimo Biondi
The current debate about the diagnostic significance of delusion revolves around two positions. The neurocognitive position conceives delusion as a non-specific, though polymorphic, symptom. The psychopathological position views features of delusion such as content and structure as having meaningful connections with diagnostic entities. This study aims at contributing to this debate by examining the association between delusional themes and diagnosis in a sample of 830 adult psychotic patients. All diagnoses were made by experienced psychiatrists according to DSM-IV or ICD-10 criteria, and in 348 patients were established with the SCID-I...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29671056/progressive-symptom-associated-prefrontal-volume-loss-occurs-in-first-episode-schizophrenia-but-not-in-affective-psychosis
#8
Toshiyuki Ohtani, Elisabetta Del Re, James J Levitt, Margaret Niznikiewicz, Jun Konishi, Takeshi Asami, Toshiro Kawashima, Tomohide Roppongi, Paul G Nestor, Martha E Shenton, Dean F Salisbury, Robert W McCarley
Although smaller gray matter volumes (GMV) in the prefrontal cortex (PFC) in schizophrenia and bipolar disorder have been reported cross-sectionally, there are, to our knowledge, no reports of longitudinal comparisons using manually drawn, gyrally based ROI, and their associations with symptoms. The object of this study was to determine whether first-episode schizophrenia (FESZ) and first-episode affective psychosis (FEAFF) patients show initial and progressive PFC GMV reduction in bilateral frontal pole, superior frontal gyrus (SFG), middle frontal gyrus (MFG), and inferior frontal gyrus (IFG) and examine their symptom associations...
April 18, 2018: Brain Structure & Function
https://www.readbyqxmd.com/read/29670200/effectiveness-of-traditional-chinese-medicineas-as-an-adjunct-therapy-for-refractory-schizophrenia-a-systematic-review-and-meta-analysis
#9
Yan-Yan Wei, Wan-Fu Lin, Tian-Hong Zhang, Yun-Xiang Tang, Ji-Jun Wang, Mao-Feng Zhong
Although recent studies focused on traditional Chinese medicine (TCM) for the treatment of refractory schizophrenia have reported that it may be beneficial, there is still lack of convincing evidence and critical meta-analytic work regarding its effectiveness as an adjunctive therapy. Therefore, we performed a meta-analysis to investigate the effectiveness of TCM in combination with antipsychotics for refractory schizophrenia. Fourteen articles involving 1725 patients published as of December 2016 were included which compared antipsychotic therapies to either TCM alone, or TCM as an adjunctive therapy...
April 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29627721/community-based-comprehensive-intervention-for-people-with-schizophrenia-in-guangzhou-china-effects-on-clinical-symptoms-social-functioning-internalized-stigma-and-discrimination
#10
Jie Li, Yuan-Guang Huang, Mao-Sheng Ran, Yu Fan, Wen Chen, Sara Evans-Lacko, Graham Thornicroft
Comprehensive interventions including components of stigma and discrimination reduction in schizophrenia in low- and middle-income countries (LMICs) are lacking. We developed a community-based comprehensive intervention to evaluate its effects on clinical symptoms, social functioning, internalized stigma and discrimination among patients with schizophrenia. A randomized controlled trial including an intervention group (n = 169) and a control group (n = 158) was performed. The intervention group received comprehensive intervention (strategies against stigma and discrimination, psycho-education, social skills training and cognitive behavioral therapy) and the control group received face to face interview...
April 3, 2018: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/29614389/duration-of-active-psychosis-and-functional-outcomes-in-first-episode-non-affective-psychosis
#11
José María Pelayo-Terán, Virginia Gajardo-Galán, Marcos Gómez-Revuelta, Victor Ortiz-García de la Foz, Rosa Ayesa-Arriola, Rafael Tabarés-Seisdedos, Benedicto Crespo-Facorro
BACKGROUND: The duration of untreated psychosis (DUP) has been associated with negative outcomes in psychosis; however, few studies have focused on the duration of active psychotic symptoms after commencing treatment (DAT). In this study, we aimed to evaluate the effect of DUP and DAT on functional long-term outcomes (3 years) in patients with early psychosis. METHODS: We evaluated the Scale for the Assessment of Positive Symptoms (SAPS) at frequent intervals for 3 years after presentation to determine the DAT for 307 individuals with first-episode psychosis together with DUP and clinical variables...
March 31, 2018: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/29565512/observation-and-analysis-of-clinical-efficacy-of-melatonin-on-aopp-induced-delirium-patients
#12
L-B Zhao, G-D Zhen, Y Zhang, Y-Y Pan, G-H Du, S-Z Zhou, Z-F Li
OBJECTIVE: To observe the clinical efficacy of melatonin on acute organophosphorus pesticide poisoning (AOPP). PATIENTS AND METHODS: In this randomized control trial, a total of 59 AOPP patients with subsequent delirium were randomly divided into two groups, the melatonin group (n=29) and the placebo-controlled group (n=30). Patients in the melatonin group (n=29) underwent oral administration of melatonin in addition to the symptomatic treatment, while those in the placebo-controlled group took a placebo in addition to the symptomatic treatment...
March 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29564636/help-seeking-patterns-in-women-with-postpartum-severe-mental-illness-a-report-from-southern-india
#13
Harish Thippeswamy, Geetha Desai, Prabha Chandra
Postpartum severe mental illness (SMI) often presents with risks to mother-infant dyad and requires early assessment and interventions. The access to psychiatric care in low and middle income countries is complex. Help-seeking patterns in women with postpartum SMI has not been studied adequately. Hence, the present study was undertaken to examine the help-seeking pattern and reasons for delay in seeking psychiatry services among postpartum women with SMI. Successive patients with a diagnosis of postpartum SMI were recruited over a period of 2 years...
March 21, 2018: Archives of Women's Mental Health
https://www.readbyqxmd.com/read/29559890/blood-gene-expression-profile-predicts-response-to-antipsychotics
#14
Jesus Sainz, Carlos Prieto, Fulgencio Ruso-Julve, Benedicto Crespo-Facorro
Antipsychotic drugs are one of the largest types of prescribed drugs and have large inter-individual differences in efficacy, but there is no methodology to predict their clinical effect. Here we show a four-gene blood expression profile to predict the response to antipsychotics in schizophrenia patients before treatment. We sequenced total mRNA from blood samples of antipsychotic naïve patients who, after 3 months of treatment, were in the top 40% with the best response (15 patients) and in the bottom 40% with the worst response (15 patients) according to the Brief Psychiatric Rating Scale (BPRS)...
2018: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29559628/neighbourhood-interactions-drive-overyielding-in-mixed-species-tree-communities
#15
Andreas Fichtner, Werner Härdtle, Helge Bruelheide, Matthias Kunz, Ying Li, Goddert von Oheimb
Theory suggests that plant interactions at the neighbourhood scale play a fundamental role in regulating biodiversity-productivity relationships (BPRs) in tree communities. However, empirical evidence of this prediction is rare, as little is known about how neighbourhood interactions scale up to influence community BPRs. Here, using a biodiversity-ecosystem functioning experiment, we provide insights into processes underlying BPRs by demonstrating that diversity-mediated interactions among local neighbours are a strong regulator of productivity in species mixtures...
March 20, 2018: Nature Communications
https://www.readbyqxmd.com/read/29502981/sexual-activity-sexual-dysfunction-and-sexual-life-quality-among-psychiatric-hospital-inpatients-with-schizophrenia
#16
Mi-Chia Ma, Jian-Kang Chao, Jia-Yi Hung, Su-Ching Sung, I-Hsin Candy Chao
BACKGROUND: Sexual dysfunction occurs commonly in patients with psychiatric illness and may be related to the primary mental disorder, comorbidity with sexual disorders or medical illness, or medications used for mental disorders treatment, but the magnitude of this problem is unknown. AIM: To estimate the prevalence of current sexual activity, sexual dysfunction, and sexual attitude and influence of factors on patients with schizophrenia. METHODS: This study used a cross-sectional design with a total of 317 patients diagnosed with schizophrenia...
March 2018: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29482712/bipolar-affective-disorder-in-a-patient-of-profound-deafness
#17
Usama Bin Zubair, Humza Mumtaz, Sawera Mansoor
Profound deafness is a lifelong impairment, leading to the physical disability as well as poor psychological adjustment. We herein present a mental health disorder rarely seen among the patients of profound deafness. A 16-year deaf and dumb girl, previously treated for depression, presented with unusual laughter, irritability, flight of ideas, decreased sleep, ideas of self importance, and decreased social functioning and educational performance. These problems were understood by the parents via sign language, who interpreted them to the interviewer...
March 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/29465560/olanzapine-and-haloperidol-for-the-treatment-of-acute-symptoms-of-mental-disorders-induced-by-amphetamine-type-stimulants-a-randomized-controlled-trial
#18
RANDOMIZED CONTROLLED TRIAL
Xiaobin Xue, Yun Song, Xiaojie Yu, Qiang Fan, Jiyou Tang, Xu Chen
BACKGROUND: This study aimed to compare olanzapine and haloperidol efficacies in the treatment of acute psychiatric symptoms due to amphetamine-type stimulants (ATSs). METHODS: The Zelen II design method was used; 124 patients with acute mental disorders due to amphetamine were randomly divided into olanzapine group (n = 63) and haloperidol group (n = 61). Then, a 4-week open-label medical therapy was performed. Clinical Global Impression Scale Item 2 was employed to evaluate the onset time; meanwhile, Brief Psychiatric Rating Scale (BPRS) was used at baseline and at posttreatment weeks 1, 2, and 4...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29461932/clinical-outcomes-from-a-10-week-follow-up-psychoeducational-program-for-dual-diagnosis
#19
J Chilton, D Crone, P J Tyson
BACKGROUND: Dual diagnosis covers a broad spectrum of mental health and substance misuse conditions occurring concurrently (NICE, 2016 ). Its manifestation is complex and, as such, the disorder is recognized as influencing adherence to prescribed medication and service engagement and has a worse prognosis than substance use and mental health conditions occurring independently. AIMS: To determine the effectiveness of psychoeducational group therapy in a sample of dual diagnosis patients...
February 20, 2018: Journal of Dual Diagnosis
https://www.readbyqxmd.com/read/29458931/assessment-of-the-psychopathological-effects-of-a-horticultural-therapy-program-in-patients-with-schizophrenia
#20
Yun-Ah Oh, Sin-Ae Park, Byung-Eun Ahn
OBJECTIVES: This study assessed the psychopathological effects of participation in a 10-session horticultural therapy program in patients with schizophrenia. DESIGN: The study design was pre and post test design of experimental and control groups. SETTING: Twenty-eight Korean patients with schizophrenia, recruited from a mental health clinic and two mental health rehabilitation centers in Suwon, South Korea, were voluntarily assigned to either a control group (average age: 33...
February 2018: Complementary Therapies in Medicine
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