Rahim Badrfam, Atefeh Zandifar, Amirhossein Hajialigol, Maryam Rashidian, Norman Brad Schmidt, Danielle Morabito, Mostafa Qorbani, Ehsan Shahrestanaki, Mahboobeh Mehrabani Natanzi
RATIONALE: Changes in the density and diversity of gut microbiota in chronic use of methamphetamine have been mentioned as contributors to psychotic and anxiety symptoms, sleep problems, and loss of appetite. OBJECTIVE: In this placebo-controlled clinical trial, we investigated the effect of the probiotic Lactobacillus Acidophilus in improving psychiatric symptoms among hospitalized patients with chronic methamphetamine use along with psychotic symptoms. METHODS: 60 inpatients with a history of more than 3 years of methamphetamine use, were randomly assigned to one of two groups receiving either a probiotic capsule or placebo along with risperidone for 8 weeks based on a simple randomization method...
March 21, 2024: Psychopharmacology