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Osteoporosis in men

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https://www.readbyqxmd.com/read/29150298/spontaneous-osteoclastogenesis-hypothesis-for-gender-unrelated-osteoporosis-screening-and-diagnosis
#1
F Salamanna, R Giardino, M Fini
Women are at greater risk of developing osteoporosis (OP). However, in the past few years it has become more widely recognized that OP is a significant problem also in men although OP is frequently under-diagnosed and, consequently, under treated in men. Most guidelines, screening and fracture risk evaluation methods as well as pharmacologic agents have been developed for women and then adapted to men. Bone Mineral Density (BMD) measurement by Dual X-ray Absorptiometry (DEXA) is reported as T score and the capability of DEXA to diagnose OP and predict fracture risk is still debated...
November 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/29143531/the-population-mean-mood-predicts-the-prevalence-of-depression-in-an-australian-context
#2
Aaron D Sia, Lana J Williams, Julie A Pasco, Felice N Jacka, Sharon L Brennan-Olsen, J Lennert Veerman
BACKGROUND: The mean population mood has been demonstrated to strongly correlate with the prevalence of depression in European populations. Mean population mood has, therefore, been proposed as both a metric to measure the impact of population-level interventions to prevent depression and a target for public health policy. AIM: To demonstrate the relationship between mean population mood and the prevalence of depression using Australian data in order to broaden the applicability of this finding to the Australian population...
November 1, 2017: Australian and New Zealand Journal of Psychiatry
https://www.readbyqxmd.com/read/29129217/screening-for-geriatric-syndromes-falls-urinary-fecal-incontinence-and-osteoporosis
#3
REVIEW
Erin M Smith, Amit A Shah
The geriatric syndromes of falls, incontinence, and osteoporosis are concerns in older adults because of their potential impact on quality of life. Asking about history of falls or a fear of falling should prompt a multifactorial assessment of fall risk and targeted interventions to reduce falls. Urinary and fecal incontinence should be screened because they are common conditions that are underreported due to embarrassment and general perception that incontinence is a normal part of aging. Women over age 65, men over age 70, and younger patients with high-risk characteristics should be screened with bone mineral density testing with dual-energy x-ray absorptiometry...
February 2018: Clinics in Geriatric Medicine
https://www.readbyqxmd.com/read/29124881/the-implications-of-baseline-bone-health-assessment-at-initiation-of-androgen-deprivation-therapy-for-prostate-cancer
#4
Peter S Kirk, Tudor Borza, Vahakn B Shahinian, Megan E V Caram, Danil V Makarov, Jeremy B Shelton, John T Leppert, Ryan M Blake, Jennifer A Davis, Brent K Hollenbeck, Anne Sales, Ted A Skolarus
OBJECTIVES: To assess bone density testing (BDT) use among prostate cancer survivors receiving ADT, and downstream implications for osteoporosis and fracture diagnoses as well as pharmacologic osteoporosis treatment in a national integrated delivery system. METHODS: We identified 17,017 men with prostate cancer who received any ADT between 2005 and 2014 using Veterans Health Administration cancer registry and administrative data. We identified claims for BDT within a 3-year period of ADT initiation...
November 10, 2017: BJU International
https://www.readbyqxmd.com/read/29115721/loss-of-skeletal-muscle-mass-in-patients-with-chronic-liver-disease-is-related-to-decrease-in-bone-mineral-density-and-exercise-tolerance
#5
Fumikazu Hayashi, Masaki Kaibori, Tatsuma Sakaguchi, Kosuke Matsui, Morihiko Ishizaki, A-Hon Kwon, Junji Iwasaka, Yutaka Kimura, Daiki Habu
AIM: This study aimed to identify the relationship between loss of skeletal muscle mass and clinical factors such as osteoporosis in patients with chronic liver disease. METHODS: The subjects were 112 patients (85 men, 27 women) with hepatocellular carcinoma who were scheduled to undergo hepatectomy. Skeletal muscle reduction was diagnosed according to the cutoff level of the skeletal mass index (SMI) for Asians (men <7.0 kg/m(2) , women <5.4 kg/m(2) ). Osteoporosis was diagnosed according to T-score ≤-2...
November 8, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29112101/thoracolumbar-intervertebral-disc-area-morphometry-in-elderly-chinese-men-and-women-radiographic-quantifications-at-baseline-and-changes-at-year-4-follow-up
#6
Jùn-Qīng Wáng, Zoltán Káplár, Min Deng, James F Griffith, Jason C S Leung, Anthony Wl Kwok, Timothy Kwok, Ping Chung Leung, Yì Xiáng J Wáng
STUDY DESIGN: A population-based radiographic study with longitudinal follow-up. OBJECTIVE: To develop a quantitative index for lumbar disc space narrowing (DSN) evaluation in elderly subjects; to determine how DSN in the elderly is influenced by osteoporosis and gender. SUMMARY OF BACKGROUND DATA: There is paucity of research on quantitative classification of lumbar DSN based on disc areal morphometry. METHODS: With the database of Osteoporotic Fractures in Men (Hong Kong) and Osteoporotic Fractures in Women (Hong Kong) Studies and those who attended the year-4 follow-up (n = 1519 for men and n = 1546 for women), data of 491 women and 592 men were randomly selected...
November 3, 2017: Spine
https://www.readbyqxmd.com/read/29106028/association-of-high-anti-cyclic-citrullinated-peptide-seropositivity-and%C3%A2-lean-mass-index-with-low-bone-mineral-density-in-rheumatoid-arthritis
#7
Katherine D Wysham, Dolores M Shoback, John B Imboden, Patricia P Katz
OBJECTIVE: Osteoporotic fractures are associated with high morbidity and mortality. Persons with rheumatoid arthritis (RA) have twice the risk of osteoporosis-related fracture than age-matched controls, the causes for which remain unknown. We investigated contributions of RA characteristics, medication use, and body composition to low bone mineral density (BMD) in patients with RA. METHODS: Data were from the Arthritis, Body Composition, and Disability Study (n=138; 82 women, 56 men)...
November 5, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/29084183/dietary-magnesium-may-be-protective-for-aging-of-bone-and-skeletal-muscle-in-middle-and-younger-older-age-men-and-women-cross-sectional-findings-from-the-uk-biobank-cohort
#8
Ailsa A Welch, Jane Skinner, Mary Hickson
Although fragility fractures, osteoporosis, sarcopenia, and frailty are becoming more prevalent in our aging society the treatment options are limited and preventative strategies are needed. Despite magnesium being integral to bone and muscle physiology, the relationship between dietary magnesium and skeletal muscle and bone health has not been investigated concurrently to date. We analysed cross-sectional associations between dietary magnesium and skeletal muscle mass (as fat free mass-FFM), grip strength, and bone density (BMD) in 156,575 men and women aged 39-72 years from the UK Biobank cohort...
October 30, 2017: Nutrients
https://www.readbyqxmd.com/read/29070951/agreement-between-calcaneal-quantitative-ultrasound-and-osteoporosis-self-assessment-tool-for-asians-in-identifying-individuals-at-risk-of-osteoporosis
#9
Kok-Yong Chin, Nie Yen Low, Alia Annessa Ain Kamaruddin, Wan Ilma Dewiputri, Ima-Nirwana Soelaiman
BACKGROUND: Calcaneal quantitative ultrasound (QUS) is a useful tool in osteoporosis screening. However, QUS device may not be available at all primary health care settings. Osteoporosis self-assessment tool for Asians (OSTA) is a simple algorithm for osteoporosis screening that does not require any sophisticated instruments. This study explored the possibility of replacing QUS with OSTA by determining their agreement in identifying individuals at risk of osteoporosis. METHODS: A cross-sectional study was conducted to recruit Malaysian men and women aged ≥50 years...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29069393/sclerostin-antibody-reverses-bone-loss-by-increasing-bone-formation-and-decreasing-bone-resorption-in-a-rat-model-of-male-osteoporosis
#10
Xiaodong Li, Michael S Ominsky, Kelly S Villasenor, Qing-Tian Niu, Frank J Asuncion, Xuechun Xia, Mario Grisanti, Thomas J Wronski, W Scott Simonet, Hua Zhu Ke
Sclerostin antibody (Scl-Ab) restored bone mass and strength in the ovariectomized rat model of postmenopausal osteoporosis. Increased bone mineral density (BMD) and decreased skeletal fragility fracture risk have been reported in postmenopausal osteoporotic women receiving Scl-Ab. In males, loss of androgen leads to rapid decreases in BMD and increased risk for fragility fractures. We hypothesized that Scl-Ab could reverse the loss of bone mass and strength caused by androgen ablation in the orchiectomized (ORX) rat model of male osteoporosis...
October 20, 2017: Endocrinology
https://www.readbyqxmd.com/read/29068999/prevalence-of-osteoporosis-and-related-lifestyle-and-metabolic-factors-of-postmenopausal-women-and-elderly-men-a-cross-sectional-study-in-gansu-province-northwestern-of-china
#11
Limin Tian, Ruifei Yang, Lianhua Wei, Jing Liu, Yan Yang, Feifei Shao, Wenjuan Ma, Tingting Li, Yu Wang, Tiankang Guo
The aim of this study was to investigate the osteoporosis prevalence and the risks of postmenopausal women and elderly men in Gansu province.This cross-sectional study involved 3359 postmenopausal women and 3205 elderly males who were randomly selected from 7 areas in Gansu province. Areal bone mineral density (BMD) (g/cm) was measured at the distal one-third radius of the nonstressed forearm using dual-energy X-ray absorptiometry (DXA: Osteometer MediTech). Factors related to osteoporosis were analyzed.The prevalence of osteoporosis in the entire study population was 9...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29068756/long-term-effect-of-pulsed-nd-yag-laser-combined-with-exercise-on-bone-mineral-density-in-men-with-osteopenia-or-osteoporosis-1-year-of-follow-up
#12
Mohamed Salaheldien Mohamed Alayat, Ehab Mohamed Abdel-Kafy, Ali Abdel Monsif Thabet, Ahmed Salman Abdel-Malek, Tariq Helmi Ali, Eslam A Header
BACKGROUND: A pulsed Nd-YAG laser is an effective physiotherapy modality used as a class IV high-intensity laser therapy (HILT). PURPOSE: The aim of this study is to investigate the efficacy of HILT alone or combined with exercise (HILT+EX) on bone mineral density (BMD) after 24 weeks and at 1 year of follow-up in men with osteopenia or osteoporosis. METHODS: One hundred men with osteopenia or osteoporosis (mean age, 53.78 [2.89] years; weight, 80...
October 25, 2017: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/29068496/effectiveness-of-oral-bisphosphonates-in-reducing-fracture-risk-among-oral-glucocorticoid-users-three-matched-cohort-analyses
#13
M Amine Amiche, Linda E Lévesque, Tara Gomes, Jonathan D Adachi, Suzanne M Cadarette
The benefit of oral bisphosphonates in reducing fracture risk among in glucocorticoid-induced osteoporosis is controversial. We aimed to estimate the effectiveness of oral bisphosphonates in reducing fracture risk in a cohort of new chronic oral glucocorticoid users. We created three matched cohorts using healthcare administrative data from Ontario, Canada. We included residents aged 66 years and older initiating chronic oral glucocorticoids (≥450 mg prednisone equivalent and ≥ 2 GC prescriptions within a 6-month window) between January 1998 and September 2014...
October 25, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29067572/age-and-gender-specific-epidemiology-treatment-patterns-and-economic-burden-of-osteoporosis-and-associated-fracture-in-taiwan-between-2009-and-2013
#14
Chen-Yu Wang, Shau-Huai Fu, Rong-Sen Yang, Li-Jiuan Shen, Fe-Lin Lin Wu, Fei-Yuan Hsiao
This nationwide study investigated the epidemiology, treatment patterns, and economic burden of osteoporosis and associated fracture in Taiwan. The treatment of osteoporosis is alarmingly suboptimal, considering the significantly increased economic burden of major osteoporotic fracture. Osteoporosis men received lesser anti-osteoporosis drugs but had higher incremental costs attributable to osteoporotic fractures. PURPOSE: This nationwide study investigated the epidemiology, treatment patterns, and economic burden of osteoporosis and associated fracture between 2009 and 2013 in Taiwan...
October 25, 2017: Archives of Osteoporosis
https://www.readbyqxmd.com/read/29063216/older-men-who-sustain-a-hip-fracture-experience-greater-declines-in-bone-mineral-density-at-the-contralateral-hip-than-non-fractured-comparators
#15
A M Rathbun, J Magaziner, M D Shardell, L M Yerges-Armstrong, D Orwig, G E Hicks, M C Hochberg
Men experience declining bone mineral density (BMD) after hip fracture; however, changes attributable to fracture are unknown. This study evaluated the excess BMD decline attributable to hip fracture among older men. Older men with hip fracture experienced accelerated BMD declines and are at an increased risk of secondary fractures. INTRODUCTION: The objective was to determine whether bone mineral density (BMD) changes in men after hip fracture exceed that expected with aging. METHODS: Two cohorts were used: Baltimore Hip Studies 7th cohort (BHS-7) and Baltimore Men's Osteoporosis Study (MOST)...
October 24, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/29063213/high-dairy-protein-intake-is-associated-with-greater-bone-strength-parameters-at-the-distal-radius-and-tibia-in-older-men-a-cross-sectional-study
#16
L Langsetmo, J M Shikany, A J Burghardt, P M Cawthon, E S Orwoll, J A Cauley, B C Taylor, J T Schousboe, D C Bauer, T N Vo, K E Ensrud
Dairy protein but not plant protein was associated with bone strength of the radius and tibia in older men. These results are consistent with previous results in women and support similar findings related to fracture outcomes. Bone strength differences were largely due to thickness and area of the bone cortex. INTRODUCTION: Our objective was to determine the association of protein intake by source (dairy, non-dairy animal, plant) with bone strength and bone microarchitecture among older men...
October 23, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/29052745/role-of-fat-and-bone-biomarkers-in-the-relationship-between-ethnicity-and-bone-mineral-density-in-older-men
#17
Grace M F Chan, Tessa Riandini, Sheryl Hui Xian Ng, Su Yen Goh, Chuen Seng Tan, E Shyong Tai, Gustavo Duque, Alvin Choon-Meng Ng, Kavita Venkataraman
Osteoporosis is an important health issue for older adults, and has been relatively understudied in older men. This study aimed to examine ethnic differences in bone mineral density (BMD), and elucidate the role of bone turnover markers (BTMs), fat and fat biomarkers on these ethnic differences. BMD at the lumbar spine and femoral neck, marrow fat at femoral neck, visceral adipose tissue (VAT) and subcutaneous adipose tissue, bone and fat biomarkers were evaluated in 120 healthy men aged ≥ 60 years. Indians had higher BMD values compared to Chinese at the lumbar spine (β = 20...
October 20, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/29051986/the-relationship-between-fatty-liver-index-and-bone-mineral-density-in-koreans-knhanes-2010-2011
#18
S H Ahn, D H Seo, S H Kim, M-S Nam, S Hong
Analyses using a nationally representative cohort have revealed that high fatty liver index (FLI) is associated with low bone mineral density (BMD) regardless of insulin resistance in men, thereby supporting the deteriorated bone metabolism in nonalcoholic fatty liver disease (NAFLD). INTRODUCTION: NAFLD is linked to deteriorated bone health. We investigated the association of FLI, a scoring model for NAFLD, with BMD. METHODS: This was a population-based, cross-sectional study from the Korea National Health and Nutrition Examination Surveys including 4264 Koreans (1908 men and 2356 women)...
October 19, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/29049519/association-of-bone-mineral-density-with-the-risk-of-intracranial-aneurysm
#19
Yong-Won Shin, Kyung-Il Park, Jangsup Moon, Soon-Tae Lee, Kon Chu, Sang Kun Lee, Jae-Kyu Roh, Keun-Hwa Jung
Importance: Disruption of extracellular matrix integrity is critically involved in both intracranial aneurysm and bone fragility. Furthermore, both intracranial aneurysm and osteoporosis have a female predominance, and sex hormones are considered to affect this discrepancy. Objective: To evaluate the association between bone mineral density and intracranial aneurysm. Design, Setting, and Participants: A cross-sectional study conducted with 14 328 patients who underwent brain magnetic resonance angiography and bone mineral densitometry as a part of a health examination at a specialized center for comprehensive health examination in Seoul, the largest metropolitan area in the Republic of Korea, between December 2004 and November 2015...
October 16, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/29044768/prevalence-of-osteoporosis-and-low-bone-mass-among-puerto-rican-older-adults
#20
Sabrina E Noel, Kelsey M Mangano, John L Griffith, Nicole C Wright, Bess Dawson-Hughes, Katherine L Tucker
Historically, osteoporosis has not been considered a public health priority for the Hispanic population. However, recent data indicate that Mexican Americans are at increased risk for this chronic condition. Although it is well established that there is heterogeneity in social, lifestyle, and health-related factors among Hispanic subgroups, there are currently few studies on bone health among Hispanic subgroups other than Mexican Americans. The current study aimed to determine the prevalence of osteoporosis and low bone mass (LBM) among 953 Puerto Rican adults, aged 47 to 79 yr and living on the U...
October 17, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
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