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Osteoporosis in men

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https://www.readbyqxmd.com/read/29777162/hiv-and-vertebral-fractures-a-systematic-review-and-metanalysis
#1
Thales A S H Ilha, Fabio V Comim, Rafaela M Copes, Juliet E Compston, Melissa O Premaor
The survival of HIV-infected patients has increased with the advent of antiretroviral therapy with the emergence of new comorbidities. Vertebral fracture is a manifestation of reduced bone strength and osteoporosis. This study aims to assess the frequency of spine fractures in HIV-positive men and women aged over 18 years. We performed a systematic review of randomized controlled trials, cohort studies, cross-sectional studies, and case-control studies. Studies that evaluated morphometric and/or clinical vertebral fracture were included...
May 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29774403/anti-osteoporosis-drug-use-too-little-too-much-or-just-right-the-hunt-study-norway
#2
M Hoff, S Skurtveit, H E Meyer, A Langhammer, A J Søgaard, U Syversen, E Skovlund, B Abrahamsen, S Forsmo, B Schei
Use of anti-osteoporotic drugs (AODs) was examined in a Norwegian population 50-85 years. Among them with Fracture Risk Assessment Tool (FRAX) score for major osteoporotic fracture ≥ 20, 25% of the women and 17% of the men received AODs. The strongest predictors for AODs were high age in women and use of glucocorticoids among men. INTRODUCTION: To examine the use of anti-osteoporotic drugs (AODs) and to identify predictors for prescriptions. METHODS: Data were obtained from the Nord-Trøndelag Health Study (HUNT3) performed in 2006-2008 and the Norwegian Prescription Database, including 15,075 women and 13,386 men aged 50-85 years...
May 17, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29762165/improved-fracture-prediction-using-different-frax-adjustments-in-hiv-infected-women
#3
Jingyan Yang, Anjali Sharma, Qiuhu Shi, Kathryn Anastos, Mardge H Cohen, Elizabeth T Golub, Deborah Gustafson, Daniel Merenstein, Wendy J Mack, Phyllis C Tien, Jeri Nieves, Michael T Yin
OBJECTIVES: A Fracture risk assessment tool (FRAX®) using clinical risk factors (CRFs) alone underestimates fracture risk in HIV-infected men. Our objective was to determine whether accuracy of FRAX would be improved by considering HIV as a cause of secondary osteoporosis, and further improved with addition of DXA parameters in HIV-infected women. DESIGN: Subgroup analysis of Women's Interagency HIV Study. METHODS: We included 1148 women (900 HIV-infected and 248 uninfected) over age 40 with data to approximate FRAX CRFs and 10-year observational data for incident fragility fractures; 181 (20%) HIV-infected women had DXA data...
May 11, 2018: AIDS
https://www.readbyqxmd.com/read/29759066/prevalence-and-comorbidity-of-osteoporosis-a-cross-sectional-analysis-on-10-660-adults-aged-50-years-and-older-in-germany
#4
Marie-Therese Puth, Manuela Klaschik, Matthias Schmid, Klaus Weckbecker, Eva Münster
BACKGROUND: Knowledge on prevalence of osteoporosis stratifying for socioeconomic background is insufficient in Germany. Little is known in Europe about other diseases that go along with it although these aspects are important for implementing effective public health strategies. METHODS: This cross-sectional analysis was based on the national telephone survey "German Health Update" (GEDA 2012) performed in 2012/2013. GEDA 2012 provides information on self-reported diseases and sociodemographic characteristics for nearly 20,000 adults...
May 14, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29738949/associations-of-urinary-polycyclic-aromatic-hydrocarbons-with-bone-mass-density-and-osteoporosis-in-u-s-adults-nhanes-2005-2010
#5
Jing Guo, Yun Huang, Suchen Bian, Chuning Zhao, Yumin Jin, Dongdong Yu, Xinkai Wu, Dan Zhang, Weiming Cao, Fangyuan Jing, Guangdi Chen
Polycyclic aromatic hydrocarbons (PAHs) are environmental endocrine disruptors, which may modify the bone mineralization. However, epidemiological evidences on this issue were scant. We aimed to investigate the associations of PAHs with bone mass density (BMD) and osteoporosis based on a nationally-representative sample from general U.S. POPULATION: Data utilized were extracted from the 2005-2010 National Health and Nutrition Examination Survey (NHANES). Nine urinary PAHs (U-PAHs) metabolites were measured as exposure biomarkers...
May 5, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29725863/persistence-of-and-switches-from-teriparatide-treatment-among-women-and-men-with-osteoporosis-in-the-real-world-a-claims-database-analysis
#6
Tomoko Usui, Masaru Funagoshi, Kahori Seto, Kazuki Ide, Shiro Tanaka, Koji Kawakami
This study investigated the real-world persistence rate and switches of teriparatide-treated patients using a claims database in Japan. The persistence rate of teriparatide at 12 months was 34.9%, and approximately one-third of the patients were not treated with any osteoporosis drugs after teriparatide. Improvement in persistence and switches are desired. PURPOSE: We aimed to elucidate the persistence rates and switches before and after teriparatide treatment in real-world osteoporosis patients based on data from a medical claims database in Japan...
May 3, 2018: Archives of Osteoporosis
https://www.readbyqxmd.com/read/29721240/mexican-patients-with-hiv-have-a-high-prevalence-of-vertebral-fractures
#7
José Antonio Mata-Marín, Carla I Arroyo-Anduiza, María de Los Ángeles Berrospe-Silva, Alberto Chaparro-Sánchez, Ana Gil-Avila, Jesús Gaytán-Martínez
Low bone mineral density (BMD) and fragility fractures are common in individuals infected with HIV, who are undergoing antiretroviral therapy (ART). In high-income countries, dual energy X-ray absorptiometrry is typically used to evaluate osteopenia or osteoporosis in HIV infected individuals. However, this technology is unavailable in low andmiddle income countries, so a different approach is needed. The aim of this study was to use X-ray scans of the spine to determine the prevalence of and associated risk factors for vertebral fractures in HIVinfected patients in a tertiary-care hospital in Mexico...
March 29, 2018: Infectious Disease Reports
https://www.readbyqxmd.com/read/29720722/development-of-comorbidities-in-men-with-prostate-cancer-treated-with-androgen-deprivation-therapy-an-australian-population-based-cohort-study
#8
Huah Shin Ng, Bogda Koczwara, David Roder, Agnes Vitry
BACKGROUND: The increasing use of androgen deprivation therapy has prompted further evaluation of its potential adverse effects as the treatment may exacerbate or increase the risk of developing new comorbid diseases. This study aims to assess the patterns of comorbidities among Australian men with prostate cancer treated with androgen deprivation therapy. METHODS: Pharmaceutical Benefits Scheme (PBS) 10% data between 1 January 2003 and 31 December 2014 was utilised in this retrospective cohort study...
May 2, 2018: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/29720299/effects-of-denosumab-after-treatment-discontinuation-a-review-of-the-literature
#9
Maryam Iranikhah, Crystal Deas, Pilar Murphy, Maisha Kelly Freeman
OBJECTIVE: To review and summarize studies on the effects of denosumab on bone mineral density following the discontinuation of therapy. DATA SOURCES: A search of PubMed (1966-July 2017) and International Pharmaceutical Abstracts (1970-July 2017) was conducted using the Medical Subject Headings (MeSH) terms denosumab, osteoporosis, and withholding treatment in combination with free term searches including the words drug holiday, discontinue, discontin*, and drug discontinuation...
March 1, 2018: Consultant Pharmacist: the Journal of the American Society of Consultant Pharmacists
https://www.readbyqxmd.com/read/29705875/association-between-metabolic-syndrome-and-osteoporosis-in-taiwanese-middle-aged-and-elderly-participants
#10
Hsin-Hui Lin, Chun-Yuan Huang, Lee-Ching Hwang
This study examined the association between metabolic syndrome and osteoporosis among middle-aged and elderly Taiwanese participants. After controlling for body mass index, age, liver and renal functions, and nutrition and exercise statuses, we found no significant association between MS and osteoporosis in either gender. PURPOSE: The term metabolic syndrome (MS) encompasses different abnormalities with independent effects on bone metabolism, which has led to inconsistencies in the association between MS and osteoporosis...
April 28, 2018: Archives of Osteoporosis
https://www.readbyqxmd.com/read/29701911/dysmobility-syndrome-independently-increases-fracture-risk-in-the-osteoporotic-fractures-in-men-mros-prospective-cohort-study
#11
Bjoern Buehring, Karen E Hansen, Brian L Lewis, Steven R Cummings, Nancy E Lane, Neil Binkley, Kristine E Ensrud, Peggy M Cawthon
We proposed the term "dysmobility syndrome" (DS) to identify individuals with impaired musculoskeletal health, a risk factor for falls and fractures. Whether DS is associated with increased risk of incident fracture is unknown. The "Osteoporotic Fractures in Men" study enrolled 5994 men ages ≥65 years, between March 2000 and April 2002. We used baseline data to determine whether DS increased fracture risk, independent of FRAX. Men met DS criteria at baseline if they had ≥3 of the following: appendicular lean mass/height2 <7...
April 27, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29696513/association-between-alcohol-consumption-and-bone-mineral-density-in-elderly-korean-men-and-women
#12
Yoosun Cho, Seulggie Choi, Kyuwoong Kim, Gyeongsil Lee, Sang Min Park
In this cross-sectional study based on Korean elderly men and women, heavy alcohol intake for men was related to low whole-body BMD and light alcohol intake for women was associated with high whole-body, lumbar, and total femur BMD. PURPOSE: Alcohol is a risk factor of osteoporosis but previous studies on its effect on bone health has been controversial. The aim of this study was to evaluate the association between alcohol intake and bone mineral density in Korean elderly men and women...
April 25, 2018: Archives of Osteoporosis
https://www.readbyqxmd.com/read/29691686/-becoming-older-with-axial-spondyloarthritis
#13
REVIEW
U Kiltz, X Baraliakos, B Buehring, J Braun
The combination of physiological age-related changes (e. g. reduction in muscle mass and function, reduction in organ function and degenerative changes in joints) and disease-specific changes of ankylosing spondylitis (AS), make older AS patients vulnerable for additional diseases. In this patient population various processes lead to a reduction in physical function, changes in posture, osteoporosis and sarcopenia, which then can result in falls and fractures, especially vertebral fractures. Mortality is increased in patients with AS, particularly in men due to an increase in cardiovascular mortality...
April 24, 2018: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/29689767/effects-of-standardized-quassinoid-rich-eurycoma-longifolia-extract-in-a-rat-model-of-osteoporosis-due-to-testosterone-deficiency-a-densitometric-morphometric-and-biomechanical-study
#14
Putri Ayu Jayusman, Isa Naina Mohamed, Ekram Alias, Sulaiman Md Dom, Ahmad Nazrun Shuid
BACKGROUND: Eurycoma longifolia (EL) is a well-known aphrodisiac herb for men. Recently, the crude extract of EL was reported to possess anti-osteoporotic activities. OBJECTIVE: This study aims to determine the bone protective effects of the standardized quassinoid-rich EL extract in testosterone-deficient rat model. METHODS: Ninety-six intact male Sprague-Dawley rats were randomized into baseline, sham, orchidectomized, and chemically castrated groups...
April 18, 2018: Journal of X-ray Science and Technology
https://www.readbyqxmd.com/read/29677309/vitamin-d-calcium-or-combined-supplementation-for-the-primary-prevention-of-fractures-in-community-dwelling-adults-us-preventive-services-task-force-recommendation-statement
#15
David C Grossman, Susan J Curry, Douglas K Owens, Michael J Barry, Aaron B Caughey, Karina W Davidson, Chyke A Doubeni, John W Epling, Alex R Kemper, Alex H Krist, Martha Kubik, Seth Landefeld, Carol M Mangione, Michael Silverstein, Melissa A Simon, Chien-Wen Tseng
Importance: Because of the aging population, osteoporotic fractures are an increasingly important cause of morbidity and mortality in the United States. Approximately 2 million osteoporotic fractures occurred in the United States in 2005, and annual incidence is projected to increase to more than 3 million fractures by 2025. Within 1 year of experiencing a hip fracture, many patients are unable to walk independently, more than half require assistance with activities of daily living, and 20% to 30% of patients will die...
April 17, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29675770/sports-participation-and-fracture-in-older-australian-men
#16
Kara L Holloway-Kew, David J Moloney, Gosia Bucki-Smith, Natalie K Hyde, Sharon L Brennan-Olsen, Elizabeth N Timney, Amelia G Dobbins, Julie A Pasco
Older men who participated in a sporting activity were less likely to sustain any fracture or major osteoporotic fracture over a 6-year follow-up period. PURPOSE: Regular weight-bearing physical activity can reduce fracture risk through an increase in bone strength, as well as reducing falls risk by improving muscle strength and balance. In this study, we aimed to determine whether a specific type of physical activity, sports participation, reduces fracture risk in older Australian men...
April 19, 2018: Archives of Osteoporosis
https://www.readbyqxmd.com/read/29674281/effects-of-tocotrienol-from-bixa-orellana-annatto-on-bone-histomorphometry-in-a-male-osteoporosis-model-induced-by-buserelin
#17
Nur-Vaizura Mohamad, Ima-Nirwana Soelaiman, Kok-Yong Chin
INTRODUCTION: Osteoporosis is a debilitating skeletal side effect of androgen deprivation therapy based on gonadotropin-releasing hormone (GnRH) agonist in men. Tocotrienol from Bixa orellana (annatto) has been demonstrated to offer protection against osteoporosis by exerting anabolic effects on bone. Thus, it may prevent osteoporosis among GnRH agonist users. OBJECTIVE: This study aimed to determine the effectiveness of annatto-tocotrienol on the bone turnover markers and bone histomorphometry in a model of male osteoporosis induced by buserelin (a GnRH agonist)...
April 16, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29670577/anatomical-variation-of-age-related-changes-in-vertebral-bone-marrow-composition-using-chemical-shift-encoding-based-water-fat-magnetic-resonance-imaging
#18
Thomas Baum, Alexander Rohrmeier, Jan Syväri, Maximilian N Diefenbach, Daniela Franz, Michael Dieckmeyer, Andreas Scharr, Hans Hauner, Stefan Ruschke, Jan S Kirschke, Dimitrios C Karampinos
Assessment of vertebral bone marrow composition has been proposed as imaging biomarker for osteoporosis, hematopoietic, and metabolic disorders. We investigated the anatomical variation of age-related changes of vertebral proton density fat fraction (PDFF) using chemical shift encoding-based water-fat magnetic resonance imaging (MRI). 156 healthy subjects were recruited (age range 20-29 years: 12/30 males/females; 30-39: 15/9; 40-49: 4/14; 50-59: 9/27; 60-69: 5/19; 70-79: 4/8). An eight-echo 3D spoiled gradient-echo sequence at 3T MRI was used for chemical shift-encoding based water-fat separation at the lumbar spine...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29667007/failure-in-diagnosis-and-under-treatment-of-osteoporosis-in-elderly-patients-with-fragility-fractures
#19
Sofia Bougioukli, Panagoula Κollia, Theodora Koromila, Sokratis Varitimidis, Michael Hantes, Theofilos Karachalios, Κonstantinos Ν Malizos, Zoe H Dailiana
We evaluated whether osteoporosis is adequately managed and treated in patients suffering from fragility fractures. Factors that influenced osteoporosis diagnosis and treatment rates were also assessed. To this end, patients with the principal diagnosis of low-energy hip, vertebral, or distal radius fractures were recruited for the study. Collected data included risk factors for osteoporosis, history of previous fractures, known history of osteoporosis, and osteoporosis treatment at the time of admission. The patients' prefracture risk profile was also assessed to determine whether osteoporosis could have been identified prior to the index fracture...
April 17, 2018: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/29665068/osteoporosis-and-hip-fracture-risk-from-routine-computed-tomography-scans-the-fracture-osteoporosis-and-ct-utilization-study-focus
#20
Annette L Adams, Heidi Fischer, David L Kopperdahl, David C Lee, Dennis M Black, Mary L Bouxsein, Shireen Fatemi, Sundeep Khosla, Eric S Orwoll, Ethel S Siris, Tony M Keaveny
Methods now exist for analyzing previously taken clinical computed tomography (CT) scans to measure a dual-energy X-ray absorptiometry (DXA)-equivalent bone mineral density (BMD) at the hip and a finite element analysis-derived femoral strength. We assessed the efficacy of this "biomechanical CT" (BCT) approach for identifying patients at high risk of incident hip fracture in a large clinical setting. Using a case-cohort design sampled from 111,694 women and men aged 65 or older who had a prior hip CT scan, a DXA within 3 years of the CT, and no prior hip fracture, we compared those with subsequent hip fracture (n = 1959) with randomly selected sex-stratified controls (n = 1979) and analyzed their CT scans blinded to all other data...
April 17, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
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