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Osteoporosis in men

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https://www.readbyqxmd.com/read/28921820/systematic-review-and-network-meta-analysis-on-the-relative-efficacy-of-osteoporotic-medications-men-with-prostate-cancer-on-continuous-androgen-deprivation-therapy%C3%A2-to-reduce-risk-of-fragility-fractures
#1
REVIEW
Yeesha Poon, Petros Pechlivanoglou, Shabbir M H Alibhai, David Naimark, Jeffrey S Hoch, Emmanuel Papadimitropoulos, Mary-Ellen Hogan, Murray Krahn
BACKGROUND: Androgen deprivation therapy (ADT) is an effective treatment for men with advanced prostate cancer, but loss of bone mineral density (BMD) is a major risk factor for fractures. This analysis evaluated the relative effectiveness of osteoporosis treatments using BMD as a surrogate endpoint for fragility fractures in men on continuous ADT. METHOD: We included randomized controlled trials studying bisphosphonates, denosumab, toremifene, and raloxifene in patients with non-metastatic prostate cancer on ADT for review...
September 18, 2017: BJU International
https://www.readbyqxmd.com/read/28916544/muscle-deficits-in-rheumatoid-arthritis-contribute-to-inferior-cortical-bone-structure-and-trabecular-bone-mineral-density
#2
Joshua F Baker, Jin Long, Sogol Mostoufi-Moab, Michele Denburg, Erik Jorgenson, Prerna Sharma, Babette S Zemel, Elena Taratuta, Said Ibrahim, Mary B Leonard
OBJECTIVE: Rheumatoid arthritis (RA) is associated with muscle loss, osteoporosis, and fracture. We examined associations between skeletal muscle mass, strength, and quality and trabecular and cortical bone deficits in patients with RA and healthy controls. METHODS: Participants, ages 18-75 years, completed whole-body dual-energy x-ray absorptiometry and peripheral quantitative computed tomography (pQCT) of the tibia to quantify appendicular lean mass and fat mass indices (ALMI, FMI), muscle density at the lower leg, trabecular bone density, and cortical bone thickness...
September 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28913546/economic-burden-of-osteoporosis-in-south-korea-claim-data-of-the-national-health-insurance-service-from-2008-to-2011
#3
Yong-Chan Ha, Ha-Young Kim, Sunmee Jang, Young-Kyun Lee, Tae-Young Kim
The purpose of this study was to estimate the current economic burden of osteoporosis in South Korea using national claim data of the Korean National Health Insurance Service (KNHIS) from 2008 to 2011. Patients aged 50 years or older were identified from KNHIS nationwide database for all records of outpatient visits or hospital admissions. Healthcare costs for osteoporotic patients included direct medical costs for hospitalization, outpatient care, and prescription drugs for the year after discharge. Healthcare costs were estimated based on the perspective of KNHIS, and calculated using a bottom-up approach...
September 14, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/28912754/the-gambian-bone-and-muscle-ageing-study-baseline-data-from-a-prospective-observational-african-sub-saharan-study
#4
Ayse Zengin, Anthony J Fulford, Yankuba Sawo, Landing M Jarjou, Inez Schoenmakers, Gail Goldberg, Ann Prentice, Kate A Ward
The Gambian Bone and Muscle Ageing Study is a prospective observational study investigating bone and muscle ageing in men and women from a poor, subsistence farming community of The Gambia, West Africa. Musculoskeletal diseases, including osteoporosis and sarcopenia, form a major part of the current global non-communicable disease burden. By 2050, the vast majority of the world's ageing population will live in low- and middle-income countries with an estimated two-fold rise in osteoporotic fracture. The study design was to characterise change in bone and muscle outcomes and to identify possible preventative strategies for fracture and sarcopenia in the increasing ageing population...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28912391/-sarcopenia-frailty-and-osteoporosis
#5
Hidenori Arai
Skeletal muscle mass declines and muscular strength also weakens with age. This is sarcopenia. Bone shows similar age-dependent changes leading to osteoporosis. Thus, the aging change of muscle and bone shows a similar change. Anatomically, skeletal muscle and bone are closely related. Sarcopenia and osteoporosis are risks of falls and fractures, and the risk for disability is also high. In addition, it is considered that vitamin D is involved in all of its etiologies, and attention to vitamin D is necessary...
2017: Clinical Calcium
https://www.readbyqxmd.com/read/28905348/-a-rare-complication-of-transrectal-electrostimulation-for-sperm-retrieval
#6
Jürgen Pannek, Dirk Leuth, Jens Wöllner
In men who wish to have children after a spinal cord injury, assisted ejaculation is frequently needed for sperm retrieval. Transrectal electrostimulation (TES) is often used for this purpose. Typical side effects of TES are autonomic dysreflexia or pain. In a 33-year old man with complete tetraplegia below C6 since 2004, TES caused massive leg spasticity, leading to transcervical fracture of the femoral neck. This previously unreported complication of TES demonstrates that, in men with long-term chronic tetraplegia, spasticity and osteoporosis, TES in anesthesia should be taken into consideration...
September 13, 2017: Aktuelle Urologie
https://www.readbyqxmd.com/read/28891093/tocotrienols-for-bone-health-a-translational-approach
#7
REVIEW
Chwan-Li Shen, Annika Klein, Kok-Yong Chin, Huanbiao Mo, Peihsuan Tsai, Rong-Sen Yang, Ming-Chien Chyu, Soelaiman Ima-Nirwana
Osteoporosis, a degenerative bone disease, is characterized by low bone mass and microstructural deterioration of bone tissue resulting in aggravated bone fragility and susceptibility to fractures. The trend of extended life expectancy is accompanied by a rise in the prevalence of osteoporosis and concomitant complications in the elderly population. Epidemiological evidence has shown an association between vitamin E consumption and the prevention of age-related bone loss in elderly women and men. Animal studies show that ingestion of vitamin E, especially tocotrienols, may benefit bone health in terms of maintaining higher bone mineral density and improving bone microstructure and quality...
August 2017: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/28891035/equal-treatment-no-evidence-of-gender-inequity-in-osteoporosis-management-in-a-coordinator-based-fragility-fracture-screening-program
#8
H Ansari, D E Beaton, R Sujic, N K Rotondi, J D Cullen, M Slater, J E M Sale, R Jain, E R Bogoch
We evaluated gender imbalance in osteoporosis management in a provincial coordinator-based fracture prevention program and found no difference by gender in treatment of high-risk fragility fracture patients. This establishes that a systemic approach with interventions for all fragility fracture patients can eliminate the gender inequity that is often observed. INRODUCTION: The purpose of this study was to evaluate an Ontario-based fracture prevention program for its ability to address the well-documented gender imbalance in osteoporosis (OP) management, by incorporating its integrated fracture risk assessments within a needs-based evaluation of equity...
September 10, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28890137/secular-trends-of-use-of-anti-osteoporosis-treatments-in-spain-a-population-based-cohort-study-including-over-1-5million-people-and-more-than-12years-of-follow-up
#9
Elisa Martín-Merino, Consuelo Huerta-Álvarez, Daniel Prieto-Alhambra, Arturo Álvarez-Gutiérrez, Dolores Montero-Corominas
OBJECTIVE: Different regulatory actions for anti-osteoporosis medication (AOM) were taken during the last years, including marketing of new drugs, safety warnings, or restrictions on the indications. We aimed to characterise the secular trends of AOM use in Spain from 2001 to 2013. METHODS: A cohort study using the Spanish Database for Pharmacoepidemiological Research in Primary Care (BIFAP), was performed. BIFAP includes anonym records for 4million patients. Participants entered the study when aged ≥50years in 2001-2013 and after 1year of data available, and were followed to an AOM prescription (including alendronate, other bisphosphonates, SERM (selective estrogen receptor modulators), strontium ranelate, teriparatide or denosumab), death, lost or the end of December 2013...
September 7, 2017: Bone
https://www.readbyqxmd.com/read/28879445/validity-reliability-and-responsiveness-to-change-of-the-osteoporosis-and-you-knowledge-scale
#10
V T Nguyen, S W Edmonds, Y Lou, D W Roblin, K G Saag, P Cram, F D Wolinsky
We studied the Osteoporosis and You knowledge scale in 7749 participants enrolled in a clinical trial. Results confirmed its psychometric properties in a diverse audience. Baseline scores were associated with better recall of bone mineral density test results at follow-up; however, the scale was not responsive to knowledge change. INTRODUCTION: The goal of this study was to confirm the measurement properties of the Osteoporosis and You (O&Y) knowledge scale using classic test theory methods in the 7749 men and women participating in the Patient Activation After DXA Result Notification (PAADRN) randomized controlled trial...
September 7, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28879338/distribution-of-medical-status-and-medications-in-elderly-patients-treated-with-dental-implant-surgery-covered-by-national-healthcare-insurance-in-korea
#11
Kyungjin Lee, Chugeum Dam, Jisun Huh, Kyeong-Mee Park, Seo-Yul Kim, Wonse Park
BACKGROUND: The purpose of this study was to investigate the distribution of systemic diseases and medications in patients older than 65 years of age who visited the hospital for implant treatment, as well as to investigate basic information about surgical complications that may occur after insured implant treatment. METHODS: A total of 126 patients over 65 years of age were treated for implant surgery from October 1, 2013 to October 30, 2016. Electronic chart review was conducted to obtain medical records, which included sex, age, systemic diseases, medication(s) being taken, and control of the medications...
June 2017: J Dent Anesth Pain Med
https://www.readbyqxmd.com/read/28878136/old-age-causes-de-novo-intracortical-bone-remodeling-and-porosity-in-mice
#12
Marilina Piemontese, Maria Almeida, Alexander G Robling, Ha-Neui Kim, Jinhu Xiong, Jeff D Thostenson, Robert S Weinstein, Stavros C Manolagas, Charles A O'Brien, Robert L Jilka
Decreased cortical thickness and increased cortical porosity are the key anatomic changes responsible for osteoporotic fractures in elderly women and men. The cellular basis of these changes is unbalanced endosteal and intracortical osteonal remodeling by the osteoclasts and osteoblasts that comprise the basic multicellular units (BMUs). Like humans, mice lose cortical bone with age, but unlike humans, this loss occurs in the face of sex steroid sufficiency. Mice are therefore an ideal model to dissect age-specific osteoporotic mechanisms...
September 7, 2017: JCI Insight
https://www.readbyqxmd.com/read/28875313/hip-fracture-risk-in-patients-with-burn-injury-a-retrospective-cohort-study-in-taiwan
#13
O Kaewboonchoo, F C Sung, C L Lin, H C Hsu, C T Kuo
This work aimed to evaluate the hip fracture risk for patients with burn injury. A total of 16,430 patients with burn injury had an adjusted hazard ratio of 1.54 to encounter a hip fracture, compared with controls without the injury. These results encourage future studies focusing on mechanisms leading to fracture associated with burn injury. INTRODUCTION: The relationship between burn injury and hip fracture risk is unclear. We conducted a retrospective cohort study to investigate this relationship...
September 5, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28875157/sex-hormones-and-quantitative-ultrasound-parameters-at-the-heel-in-men-and-women-from-the-general-population
#14
Konrad Pätzug, Nele Friedrich, Hanna Kische, Anke Hannemann, Henry Völzke, Matthias Nauck, Brian G Keevil, Robin Haring
PURPOSE/INTRODUCTION: The present study investigates potential associations between liquid chromatography-mass spectrometry (LC-MS) measured sex hormones, dehydroepiandrosterone sulphate, sex hormone-binding globulin (SHBG) and bone ultrasound parameters at the heel in men and women from the general population. METHODS: Data from 502 women and 425 men from the population-based Study of Health in Pomerania (SHIP-TREND) were used. Cross-sectional associations of sex hormones including testosterone (TT), calculated free testosterone (FT), dehydroepiandrosterone sulphate (DHEAS), androstenedione (ASD), estrone (E1) and SHBG with quantitative ultrasound (QUS) parameters at the heel, including broadband ultrasound attenuation (BUA), speed of sound (SOS) and stiffness index (SI) were examined by analysis of variance (ANOVA) and multivariable quantile regression models...
December 2017: Bone Reports
https://www.readbyqxmd.com/read/28874254/-the-significance-of-hiv-to-bone-mineral-density
#15
Maria Wessman, Nina Weis, Terese L Katzenstein, Anne-Mette Lebech, Kristina Thorsteinsson, Ann-Brit Eg Hansen, Jens-Erik Beck Jensen
The life expectancy in well-treated HIV-infected persons approaches that of the general population, but HIV-infected persons have a greater incidence of fractures and osteoporosis. A decrease in bone mineral density is observed primarily during the first 1-2 years of antiretroviral therapy. Dual X-ray absorptiometry scan should be considered in HIV-infected men ≥ 50 years and postmenopausal women. In case of osteoporosis, bisphosphonate treatment should follow guidelines for the general population. Future research should focus on pathogenesis and prevention of bone density loss in HIV...
September 4, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/28857846/utility-of-trabecular-bone-score-in-the-evaluation-of-osteoporosis
#16
Patrick Martineau, Barbara C Silva, William D Leslie
PURPOSE OF REVIEW: Trabecular bone score (TBS) is a lumbar spine dual-energy absorptiometry texture index which provides information on skeletal quality partially independent of bone mineral density (BMD). A body of work has emerged demonstrating the relationship between TBS and fracture risk, with lower TBS values associated with increased risk for osteoporotic fracture in postmenopausal women and older men. TBS is derived from standard DXA images; however, the information provided by TBS is complementary to that provided by BMD...
August 28, 2017: Current Opinion in Endocrinology, Diabetes, and Obesity
https://www.readbyqxmd.com/read/28852407/the-association-between-bone-quality-and-atherosclerosis-results-from-two-large-population-based-studies
#17
V Lange, M Dörr, U Schminke, H Völzke, M Nauck, H Wallaschofski, A Hannemann
OBJECTIVE: It is highly debated whether associations between osteoporosis and atherosclerosis are independent of cardiovascular risk factors. We aimed to explore the associations between quantitative ultrasound (QUS) parameters at the heel with the carotid artery intima-media thickness (IMT), the presence of carotid artery plaques, and the ankle-brachial index (ABI). METHODS: The study population comprised 5680 men and women aged 20-93 years from two population-based cohort studies: Study of Health in Pomerania (SHIP) and SHIP-Trend...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28851429/development-of-prediction-equations-for-estimating-appendicular-skeletal-muscle-mass-in-japanese-men-and-women
#18
Taishi Furushima, Motohiko Miyachi, Motoyuki Iemitsu, Haruka Murakami, Hiroshi Kawano, Yuko Gando, Ryoko Kawakami, Kiyoshi Sanada
BACKGROUND: This study aimed to develop and cross-validate prediction equations for estimating appendicular skeletal muscle mass (ASM) and to examine the relationship between sarcopenia defined by the prediction equations and risk factors for cardiovascular diseases (CVD) or osteoporosis in Japanese men and women. METHODS: Subjects were healthy men and women aged 20-90 years, who were randomly allocated to the following two groups: the development group (D group; 257 men, 913 women) and the cross-validation group (V group; 119 men, 112 women)...
August 29, 2017: Journal of Physiological Anthropology
https://www.readbyqxmd.com/read/28844568/radiographic-measurements-of-the-hip-joint-and-their-associations-with-hip-pain-in-japanese-men-and-women-the-research-on-osteoarthritis-osteoporosis-against-disability-road-study
#19
T Iidaka, S Muraki, H Oka, R Kodama, S Tanaka, H Kawaguchi, K Nakamura, T Akune, N Yoshimura
OBJECTIVE: To investigate radiographic measurements of the hip joint and their associations with hip pain, and the prevalence of acetabular dysplasia defined by radiographic measurements of the hip joint in Japanese men and women using the large-scale population-based cohort of the Research on Osteoarthritis/osteoporosis Against Disability (ROAD) study. METHODS: From the baseline survey of the ROAD study (cross-sectional study), 2963 participants (1040 men, 1923 women; mean age, 70...
August 24, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28832241/gender-differences-and-socioeconomic-factors-related-to-osteoporosis-a-cross-sectional-analysis-of-nationally-representative-data
#20
Jin-Won Noh, Hyunchun Park, Minji Kim, Young Dae Kwon
BACKGROUND: Osteoporosis has been considered a disease that primarily affects women, but recently male osteoporosis is also attracting attention. This study aims to comparatively analyze socioeconomic and other factors that are related to the prevalence of osteoporosis in both men and women. MATERIALS AND METHODS: This study used data from the Korean Community Health Survey conducted in 2013. To determine factors related to osteoporosis prevalence, researchers applied a binary logistic regression model, first for all research participants, then separately for male and female participants...
August 23, 2017: Journal of Women's Health
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