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Breast cancer and fertility

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https://www.readbyqxmd.com/read/28624978/preferences-for-breast-cancer-risk-reduction-among-brca1-brca2-mutation-carriers-a-discrete-choice-experiment
#1
Alexander Liede, Carol A Mansfield, Kelly A Metcalfe, Melanie A Price, Carrie Snyder, Henry T Lynch, Sue Friedman, Justyna Amelio, Joshua Posner, Steven A Narod, Geoffrey J Lindeman, D Gareth Evans
PURPOSE: Unaffected women who carry BRCA1 or BRCA2 mutations face difficult choices about reducing their breast cancer risk. Understanding their treatment preferences could help us improve patient counseling and inform drug trials. The objective was to explore preferences for various risk-reducing options among women with germline BRCA1/2 mutations using a discrete-choice experiment survey and to compare expressed preferences with actual behaviors. METHODS: A discrete-choice experiment survey was designed wherein women choose between hypothetical treatments to reduce breast cancer risk...
June 17, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28609273/knowledge-regarding-fertility-preservation-in-cancer-patients-a-population-based-survey-among-brazilian-people-during-the-pink-october-awareness-event
#2
Mauricio B Chehin, Tatiana Cs Bonetti, Paulo C Serafini, Eduardo LA Motta
OBJECTIVE: The aim of this study was to assess the knowledge about the risk of infertility in cancer patients after treatment, and the options for fertility preservation based on a survey carried out during the 2013 Pink October campaign. METHODS: This survey was carried out during the 2013 Pink October event in the most important public park of São Paulo, Brazil. Approximately 900 people expressed interest in learning about breast cancer prevention and fertility preservation by participating in workshops, and 242 people filled out a questionnaire...
June 1, 2017: JBRA Assisted Reproduction
https://www.readbyqxmd.com/read/28603643/assessing-the-usefulness-and-acceptability-of-a-low-health-literacy-online-decision-aid-about-reproductive-choices-for-younger-women-with-breast-cancer-the-alliance-pilot-study-protocol
#3
Michelle Peate, Sian Karen Smith, Victoria Pye, Alice Hucker, Catharyn Stern, Lesley Stafford, Catherine Oakman, Laura Chin-Lenn, Kerry Shanahan, Nipuni Ratnayake Gamage, Martha Hickey
BACKGROUND: Young women diagnosed with breast cancer may be confronted by many difficult decisions, especially around fertility preservation prior to commencing cancer treatment. The information to be conveyed is complex, and it may be difficult to weigh up the risks and benefits of the different fertility preservation options available. This complexity is compounded by the widespread low levels of literacy and health literacy in Australia, which may result in greater difficulties in understanding available health information and in decision-making...
2017: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/28600105/ovarian-stimulation-and-risk-of-breast-cancer-in-swedish-women
#4
Frida E Lundberg, Anastasia N Iliadou, Kenny Rodriguez-Wallberg, Christina Bergh, Kristina Gemzell-Danielsson, Anna L V Johansson
OBJECTIVE: To investigate whether ovarian stimulation for treating infertility is associated with the risk of breast cancer. DESIGN: Nationwide register-based cohort study. SETTING: Not applicable. PATIENT(S): In a cohort of 1,340,211 women who gave birth 1982-2012, we investigated the relationship between assisted reproductive technology (ART) and incidence of breast cancer. Associations between any ovarian stimulation since 2005 and breast cancer incidence were studied in a separate cohort of 1,877,140 women born 1960-92...
June 6, 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28591594/oleanolic-bioenhancer-coloaded-chitosan-modified-nanocarriers-attenuate-breast-cancer-cells-by-multimode-mechanism-and-preserve-female-fertility
#5
Monika Sharma, Shweta Sharma, Vikas Sharma, Komal Sharma, Santosh Kumar Yadav, Pankaj Dwivedi, Satish Agrawal, Sarvesh Kumar Paliwal, Anil Kumar Dwivedi, Jagdamba Prasad Maikhuri, Gopal Gupta, Prabhat Ranjan Mishra, Ajay Kumar Singh Rawat
Addressing multidrug resistant stage of breast cancer is an impediment for chemotherapy. Moreover, breast cancer chemotherapy has potential enduring confrontations i.e. related toxicity including effect on fertility of young female patients. The co-delivery of polyphenolic bio-enhancers with oleanolic acid in chitosan coated PLGA nanoparticles was designed for oral delivery with enhanced antitumor effect consecutively preserving the female fertility. The optimized oleanolic- bio-enhancer nano formulation CH-OA-B-PLGA with particle size was 342...
June 4, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28567743/the-use-of-selective-progestin-receptor-modulators-sprm-and-more-specifically-ulipristal-acetate-in-the-practice-of-gynaecology
#6
REVIEW
Serge Rozenberg, Julie Praet, Eliza Pazzaglia, Christine Gilles, Yannick Manigart, Jean Vandromme
This review discusses the development of selective progestin receptor modulators (SPRM) for use in women's health and specifically the use of ulipristal acetate (UPA) as emergency contraception (EC) and as a treatment for symptomatic fibroids in women who want to preserve their fertility or avoid a hysterectomy. As an EC, UPA 30 mg should be recommended for women, within 102 h of unprotected intercourse. As a treatment of fibroids, UPA (5 mg daily dose) should be administered for periods of three months as a pre-surgical strategy, reducing bleeding and fibroid size and facilitating surgery...
June 1, 2017: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/28538003/use-of-fertility-medications-and-cancer-risk-a-review-and-update
#7
Lindsay Kroener, Daniel Dumesic, Zain Al-Safi
PURPOSE OF REVIEW: There is increasing use of fertility medications for ovulation induction and ovarian stimulation for in-vitro fertilization in the treatment of female infertility. In this review, recent literature regarding the association between fertility medication and cancer risk is reviewed. RECENT FINDINGS: Several important publications have recently addressed the relationship between use of fertility medications and cancer risk. There are methodological limitations to many of these studies, including unique challenges in studying rare cancers that often develop several years after the time of fertility medication exposure...
May 22, 2017: Current Opinion in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28526012/the-pregnancy-and-fertility-prefer-study-an-italian-multicenter-prospective-cohort-study-on-fertility-preservation-and-pregnancy-issues-in-young-breast-cancer-patients
#8
Matteo Lambertini, Paola Anserini, Valeria Fontana, Francesca Poggio, Giuseppina Iacono, Annalisa Abate, Alessia Levaggi, Loredana Miglietta, Claudia Bighin, Sara Giraudi, Alessia D'Alonzo, Eva Blondeaux, Davide Buffi, Francesco Campone, Domenico F Merlo, Lucia Del Mastro
BACKGROUND: Fertility and pregnancy issues are of key importance for young breast cancer patients. Despite several advances in the field, there are still multiple unmet needs and barriers in discussing and dealing with these concerns. To address the significant challenges related to fertility and pregnancy issues, the PREgnancy and FERtility (PREFER) study was developed as a national comprehensive program aiming to optimize care and improve knowledge around these topics. METHODS: The PREFER study is a prospective cohort study conducted across several Italian institution affiliated with the Gruppo Italiano Mammella (GIM) group evaluating patterns of care and clinical outcomes of young breast cancer patients dealing with fertility and pregnancy issues...
May 19, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28521649/-am-i-really-gonna-go-sixty-years-without-getting-cancer-again-uncertainty-and-liminality-in-young-women-s-accounts-of-living-with-a-history-of-breast-cancer
#9
Sophie Rees
Although much research has examined the experience of breast cancer, the distinctive perspectives and lives of young women have been relatively neglected. Women diagnosed with breast cancer under the age of 45, and who had completed their initial treatment, were interviewed, and social constructionist grounded theory methods were used to analyse the data. The end of initial treatment was accompanied by a sense of unease and uncertainty in relation to recurrence and survival, and also fertility and menopausal status...
May 2017: Health (London)
https://www.readbyqxmd.com/read/28518096/invasive-behavior-of-human-breast-cancer-cells-in-embryonic-zebrafish
#10
Jiang Ren, Sijia Liu, Chao Cui, Peter Ten Dijke
In many cases, cancer patients do not die of a primary tumor, but rather because of metastasis. Although numerous rodent models are available for studying cancer metastasis in vivo, other efficient, reliable, low-cost models are needed to quickly access the potential effects of (epi)genetic changes or pharmacological compounds. As such, we illustrate and explain the feasibility of xenograft models using human breast cancer cells injected into zebrafish embryos to support this goal. Under the microscope, fluorescent proteins or chemically labeled human breast cancer cells are transplanted into transgenic zebrafish embryos, Tg (fli:EGFP), at the perivitelline space or duct of Cuvier (Doc) 48 h after fertilization...
April 25, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28514121/-shift-work-and-its-health-hazards
#11
David Rabinerson, Lizy Markovitch, Rinnat Gabbay-Ben-Ziv
Work in repeated changing shifts, in general, and night-shifts, in particular, is considered a necessity, encompassing many professions, among them physicians and nurses. This type of work has been shown to adversely affect the normal function of the human body circadian rhythm. This negative influence in turn, is considered to increase characteristic types of morbidity such as metabolic syndrome, type 2 diabetes and increased rate of cardiovascular morbidity. Women working in night-shifts in particular, have been found to face increased rates of breast cancer, as well as menstrual disturbances and decreased fertility...
July 2016: Harefuah
https://www.readbyqxmd.com/read/28510469/outer-dense-fiber-proteins-bridging-between-male-infertility-and-cancer
#12
Faezeh Azizi, Soudeh Ghafouri-Fard
BACKGROUND: The similarities between gametogenic and carcinogenesis processes have been noted for more than decades. Among prominent similarities between these two processes is expression of a group of antigens, namely cancer-testis antigens in both the testes and various cancer tissues. Outer dense fiber (ODF) proteins are testis-specific proteins localized to sperm tails and involved in sperm motility. METHODS: We performed a computerized search of the MEDLINE/PUBMED databases with keywords "outer dense fiber, ODF, cancer, testis, gametogenesis and infertility"...
May 2017: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/28503722/fertility-preservation-with-ovarian-stimulation-and-time-to-treatment-in-women-with-stage-ii-iii-breast-cancer-receiving-neoadjuvant-therapy
#13
A Jo Chien, Julia Chambers, Fiona Mcauley, Tessa Kaplan, Joseph Letourneau, Jimmy Hwang, Mi-Ok Kim, Michelle E Melisko, Hope S Rugo, Laura J Esserman, Mitchell P Rosen
PURPOSE: To determine whether fertility preservation with ovarian stimulation (OS) results in treatment delay in breast cancer (BC) patients receiving neoadjuvant therapy (NAT). METHODS: This is a retrospective study of women screened for the prospective neoadjuvant ISPY2 trial at the University of California San Francisco. All patients were <43, had stage II-III BC, and received neoadjuvant therapy. Time to initiation of NAT was compared between women who underwent OS (STIM) and women who did not (control)...
May 13, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28503254/management-of-potential-long-term-toxicities-in-breast-cancer-patients
#14
C C O'Sullivan, K J Ruddy
Breast cancer is the most common non-cutaneous malignancy among women, and there are over 3 million breast cancer survivors living in the United States today. Excellent cure rates with modern therapies are associated with substantial toxicities for many women; it is important that health care providers attend to the resulting symptoms and issues to optimize quality of life in this population. In this article, we review management options for potential long term toxicities in breast cancer survivors, with a particular focus on bone health, fertility preservation, premature menopause, cardiac dysfunction, and cognitive impairment...
December 2016: Current Breast Cancer Reports
https://www.readbyqxmd.com/read/28499912/cyclophosphamide-and-acrolein-induced-oxidative-stress-leading-to-deterioration-of-metaphase-ii-mouse-oocyte-quality
#15
Roohi Jeelani, Sana N Khan, Faten Shaeib, Hamid-Reza Kohan-Ghadr, Sarah R Aldhaheri, Tohid Najafi, Mili Thakur, Robert Morris, Husam M Abu-Soud
Cyclophosphamide (CTX) is a chemotherapeutic agent widely used to treat ovarian, breast, and hematological cancers as well as autoimmune disorders. Such chemotherapy is associated with reproductive failure and premature ovarian insufficiency. The mechanism by which CTX and/or its main metabolite, acrolein, affect female fertility remains unclear, but it is thought to be caused by an overproduction of reactive oxygen species (ROS). Here, we investigated the effect of CTX on metaphase II mouse oocytes obtained from treated animals (120mg/kg, 24h of single treatment), and oocytes directly exposed to increasing concentrations of CTX and acrolein (n=480; 0, 5, 10, 25, 50, and 100μM) with and without cumulus cells (CCs) for 45min which correlates to the time of maximum peak plasma concentrations after administration...
May 9, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28498013/disparities-in-counseling-female-cancer-patients-for-fertility-preservation
#16
Angela K Lawson, Jamie M McGuire, Edernst Noncent, John F Olivieri, Kristin N Smith, Erica E Marsh
BACKGROUND: Female cancer patients who are exposed to gonadotoxic chemotherapy are at risk of future infertility. Research suggests that disparities in fertility preservation counseling (FPC) may exist. Previous research is limited by recall bias; therefore, this study examined objective electronic medical chart data regarding FPC at an academic medical center. MATERIALS AND METHODS: This study included reproductive-aged women (18-45 years old) with a diagnosis of breast, gynecological, or hematological cancer and who were exposed to a gonadotoxic chemotherapeutic agent from 2009 to 2013...
May 12, 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/28473195/-does-fertility-treatment-increase-the-risk-of-breast-cancer-current-knowledge-and-meta-analysis
#17
V Gabriele, J-C Benabu, J Ohl, C Akladios Youssef, C Mathelin
OBJECTIVE: The objective of this review was to assess the level of risk of breast cancer for women exposed to ovulation-inducing therapy (OIT). METHODS: The 25 selected studies were extracted from the PUBMED database from January 2000 until March 2016 with the following key-words: "fertility agents", "infertility treatments", "clomiphene citrate", "buserelin", "ovarian stimulation", "assisted reproductive technology" and "breast cancer". Our meta-analysis was performed using Review Manager software, Cochrane Collaboration, 2014...
May 2017: Gynecologie, Obstetrique, Fertilite & Senologie
https://www.readbyqxmd.com/read/28463857/controversies-about-fertility-and-pregnancy-issues-in-young-breast-cancer-patients-current-state-of-the-art
#18
Matteo Lambertini, Oranite Goldrat, Florian Clatot, Isabelle Demeestere, Ahmad Awada
PURPOSE OF REVIEW: For trying to help physicians in counseling their young patients with breast cancer interested in fertility preservation and future reproductive plans, this manuscript aims to perform an overview of the main available data on 10 controversies in this field. RECENT FINDINGS: Thanks to the improvement in patients' prognosis, a growing attention towards fertility and pregnancy issues has been given over the past years and is currently provided to young breast cancer patients...
July 2017: Current Opinion in Oncology
https://www.readbyqxmd.com/read/28463758/prospective-evaluation-of-serum-anti-m%C3%A3-llerian-hormone-dynamics-in-250-women-of-reproductive-age-treated-with-chemotherapy-for-breast-cancer
#19
A Dezellus, P Barriere, M Campone, C Lemanski, L Vanlemmens, L Mignot, T Delozier, C Levy, C Bendavid, M Debled, T Bachelot, C Jouannaud, C Loustalot, M A Mouret-Reynier, A Gallais-Umbert, D Masson, T Freour
AIM: Women of reproductive age with breast cancer generally receive gonadotoxic chemotherapy. Fertility issues are of great concern for them. However, little is known on ovarian damage during chemotherapy and its evolution during long-term follow-up. The aim of this study was to provide a detailed description of serum anti-Müllerian hormone (AMH) evolution during chemotherapy and 24-month follow-up. METHODS: This prospective cohort study was conducted in 250 patients, aged 18-39 years, diagnosed with breast cancer and treated with adjuvant/neoadjuvant chemotherapy...
April 29, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28463728/binding-of-bisphenol-f-a-bisphenol-analogue-to-calf-thymus-dna-by-multi-spectroscopic-and-molecular-docking-studies
#20
Afia Usman, Masood Ahmad
BPF (Bisphenol-F), a member of the bisphenol family, having a wide range of industrial applications is gradually replacing Bisphenol-A. It is a recognized endocrine disrupting chemical (EDC). EDCs have been implicated in increased incidences of breast, prostate and testis cancers besides diabetes, obesity and decreased fertility. Due to the adverse effects of EDCs on human health, attempts have been directed towards their mechanism of toxicity especially at the molecular level. Hence, to understand the mechanism at the DNA level, interaction of BPF with calf thymus DNA was studied employing multi-spectroscopic, voltammetric and molecular docking techniques...
April 29, 2017: Chemosphere
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