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https://www.readbyqxmd.com/read/29661668/no-association-between-metoclopramide-treatment-in-ed-and-reduced-risk-of-post-concussion-headache
#1
Natalie Bresee, Mary Aglipay, Alexander Sasha Dubrovsky, Andrée-Anne Ledoux, Franco Momoli, Jocelyn Gravel, Stephen B Freedman, Karen Barlow, Lawrence Richer, Nicholas J Barrowman, Roger Zemek
OBJECTIVE: There is a lack of definitive pediatric literature on effective pharmacotherapy for persistent post-concussion headache symptoms. This study assessed whether acute metoclopramide treatment in the Emergency Department (ED) was associated with a reduction in persistent headache in children at 1- and 4-weeks post-concussion. METHODS: Children aged 8-17years with acute concussion presenting to 9-Canadian Pediatric EDs were enrolled in a prospective cohort study, from August 2013-June 2015...
April 7, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29602299/identification-of-human-skeletal-muscle-mirna-related-to-strength-by-high-throughput-sequencing
#2
Cameron J Mitchell, Randall F D'Souza, William Schierding, Nina Zeng, Farha Ramzan, Justin M O'Sullivan, Sally D Poppitt, David Cameron-Smith
The loss of muscle size, strength and quality with ageing is a major determinant of morbidity and mortality in the elderly. The regulatory pathways that impact on the muscle phenotype include the translational regulation maintained by microRNAs (miRNA). Yet the miRNAs that are expressed in human skeletal muscle and relationship to muscle size, strength and quality are unknown. Using next-generation sequencing, the 50 most abundantly expressed miRNAs were selected and then analysed in m. vastus lateralis, obtained by biopsy from middle-aged males (n=48; 50...
March 30, 2018: Physiological Genomics
https://www.readbyqxmd.com/read/24785862/noninvasive-prenatal-testing-for-microdeletion-syndromes-and-expanded-trisomies-proceed-with-caution
#3
Neeta L Vora, Barbara M OʼBrien
The identification of circulating cell-free fetal DNA in maternal plasma has led to the introduction of noninvasive prenatal tests with high sensitivity and high specificity for common aneuploidies (trisomy 13, trisomy 18, trisomy 21). A new expanded noninvasive prenatal testing panel that includes five microdeletion syndromes (22q11 deletion syndrome, cri-du-chat [5p minus], Prader Willi or Angelman syndrome, 1p36 deletion syndrome) and two aneuploidies usually associated with nonviable pregnancies (trisomy 16 and trisomy 22) is now available...
May 2014: Obstetrics and Gynecology
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