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diabetic nephropathy and retinopathy

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https://www.readbyqxmd.com/read/28073426/the-prevention-and-treatment-of-retinal-complications-in-diabetes
#1
Susanne Gabriele Schorr, Hans-Peter Hammes, Ulrich Alfons Müller, Heinz-Harald Abholz, Rüdiger Landgraf, Bernd Bertram
BACKGROUND: Microvascular complications of diabetes mellitus can cause retino pathy and maculopathy, which can irreversibly damage vision and lead to blindness. The prevalence of retinopathy is 9-16% in patients with type 2 diabetes and 24-27% in patients with type 1 diabetes. 0.2-0.5% of diabetics are blind. METHODS: The National Disease Management Guideline on the prevention and treatment of retinal complications in diabetes was updated according to recommendations developed by seven scientific medical societies and organizations and by patient representatives and then approved in a formal consensus process...
December 2, 2016: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/28055075/oral-pharmacologic-treatment-of-type-2-diabetes-mellitus-a-clinical-practice-guideline-update-from-the-american-college-of-physicians
#2
Amir Qaseem, Michael J Barry, Linda L Humphrey, Mary Ann Forciea
Description: The American College of Physicians (ACP) developed this guideline to present the evidence and provide clinical recommendations on oral pharmacologic treatment of type 2 diabetes in adults. This guideline serves as an update to the 2012 ACP guideline on the same topic. This guideline is endorsed by the American Academy of Family Physicians. Methods: This guideline is based on a systematic review of randomized, controlled trials and observational studies published through December 2015 on the comparative effectiveness of oral medications for type 2 diabetes...
January 3, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28052873/path-of-translational-discovery-of-urological-complications-of-obesity-and-diabetes-ucod
#3
Firouz Daneshgari, Guiming Liu, Ann T Hanna-Mitchell
Diabetes Mellitus (DM) is a prevalent chronic disease. Type 1 diabetes mellitus (T1DM) is a metabolic disorder that is characterized by hyperglycemia in the context of absolute lack of insulin; whereas type 2 diabetes mellitus (T2DM) is due to insulin resistance-related relative insulin deficiency. Obesity is an established risk factor for T2DM. In comparison with T1DM, T2DM is more complex. The natural history of T2DM in most patients typically involves a course of obesity to impaired glucose tolerance, to insulin resistance and hyperglycemia...
January 4, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28052647/the-modulative-effects-of-microcurrent-electrical-nerve-stimulation-on-diabetic-mice
#4
Wen-Ching Huang, Wen-Chieh Chang, Yi-Ju Hsu, Chun-Feng Huang, Chi-Chang Huang, Cheng-Yan Kao, Che-Li Lin
Diabetes (one of non-communicable diseases) is serious due to its complications, such like, cardiovascular ailments, neuropathy, nephropathy, retinopathy, wound gangrene and sexual impotence. Diabetes and associated chronic conditions are rapidly emerging as major health problems. In clinical, there were different drugs for diabetes treatment on different mechanisms. However, there were limited studies on the efficacy of electric stimulations on diabetes therapeutic application. In current study, we try to evaluate the effect of microcurrent electrical nerve stimulator (MENS) on diabetes modulation as an alternative medicine...
28, 2017: Chinese Journal of Physiology
https://www.readbyqxmd.com/read/28050765/association-of-periodontal-disease-with-glycemic-control-in-patients-with-type-2-diabetes-in-indian-population
#5
Palka Kaur Khanuja, Satish Chander Narula, Rajesh Rajput, Rajinder Kumar Sharma, Shikha Tewari
This study aims to investigate the link between glycated hemoglobin and diabetic complications with chronic periodontitis. A total of 207 patients with type 2 diabetes and chronic periodontitis (CP) were divided according to tertiles of mean PISA (periodontal inflamed surface area) scores as low, middle and high PISA groups. Simultaneously a group of 67 periodontally healthy individuals (PH) was recruited. Periodontal examinations, including full-mouth assessment of probing depths (PPD), bleeding on probing, clinical attachment level and plaque scores were determined...
January 3, 2017: Frontiers of Medicine
https://www.readbyqxmd.com/read/28039584/association-between-microfibrillar-associated-protein-4-mfap4-and-micro-and-macrovascular-complications-in-long-term-type-1-diabetes-mellitus
#6
S L Blindbæk, A Schlosser, A Green, U Holmskov, G L Sorensen, J Grauslund
AIMS: To evaluate microfibrillar-associated protein 4 (MFAP4) as a marker of micro- and macrovascular complications in patients with type 1 diabetes. METHODS: This cross-sectional study included 203 persons with a long duration of type 1 diabetes from a population-based cohort ascertained in the former Funen County, Denmark. Detection of plasma-MFAP4 (pMFAP4) was performed by the AlphaLISA Technique. Diabetic retinopathy (DR) was graded in accordance with the Early Treatment Diabetic Retinopathy Study adaptation of the modified Airlie House classification...
December 30, 2016: Acta Diabetologica
https://www.readbyqxmd.com/read/28034290/marine-algae-as-a-prospective-source-for-antidiabetic-compounds-a-brief-review
#7
S P Unnikrishnan, A M Jayasri
Diabetes mellitus (DM) is a metabolic disorder characterized by chronic hyperglycaemia, which is attributed by several life threatening complications including atherosclerosis, nephropathy, and retinopathy. The current therapies available for the management of DM mainly include oral antidiabetic drugs and insulin injections. However, continuous use of synthetic drugs provides lower healing with many side effects. Therefore, there is an urge for safe and efficient antidiabetic drugs for the management of DM...
December 29, 2016: Current Diabetes Reviews
https://www.readbyqxmd.com/read/28026096/interarm-blood-pressure-differences-predict-target-organ-damage-in-type-2-diabetes
#8
Francesco Spannella, Federico Giulietti, Massimiliano Fedecostante, Maddalena Ricci, Paolo Balietti, Guido Cocci, Laura Landi, Anna Rita Bonfigli, Massimo Boemi, Emma Espinosa, Riccardo Sarzani
Patients with type 2 diabetes mellitus are at high risk for atherosclerotic disease, and proper blood pressure measurement is mandatory. The authors examined the prevalence of an interarm difference (IAD) in blood pressure and its association with cardiovascular risk factors and organ damage (nephropathy, retinopathy, left ventricular hypertrophy, and vascular damage) in a large diabetic population. A total of 800 consecutive patients with type 2 diabetes mellitus were evaluated with an automated simultaneous bilateral device (men: 422 [52...
December 27, 2016: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/28009969/the-role-of-connexin43-in-diabetic-microvascular-complications
#9
Hui Li, Fang Wang
Diabetes mellitus is one of the largest global healthcare problems. People with diabetes have high risk of developing any of the microvascularcomplications, including retinopathy, nephropathy, and neuropathy, which can bring much more serious psychological and economic burden for the diabetic patients. As a consequence of its microvascular complications, diabetes has become the leading cause of blindness, end-stage renal disease, and a variety of debilitating neuropathies. Although the mechanisms involved in the development and progression of these three diabetic microvascular complications are different and have not been completely elucidated, some common histopathological features like increased vascular permeability and apoptosis of specific vascular cells are shared in retinopathy and nephropathy...
November 2016: Discovery Medicine
https://www.readbyqxmd.com/read/28008597/physician-participation-in-meaningful-use-and-quality-of-care-for-medicare-fee-for-service-enrollees
#10
Hye-Young Jung, Mark Aaron Unruh, Joshua R Vest, Lawrence P Casalino, Lisa M Kern, Zachary M Grinspan, Yuhua Bao, Rainu Kaushal
OBJECTIVES: The Meaningful Use initiative has made nearly $30 billion available through incentive programs to encourage provider adoption and use of electronic health records. The objective of this study was to evaluate the impact of outpatient physicians' participation in Meaningful Use on the quality of care provided to Medicare fee-for-service (FFS) enrollees. DESIGN: Retrospective cohort study. SETTING: One hundred percent inpatient and outpatient Medicare FFS claims covering the period January 2010 through December 2012...
December 23, 2016: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28008584/changes-in-quality-of-diabetes-care-and-morbidity-over-20-years-in-people-with-type-1-diabetes-and-long-diabetes-duration-the-jevin-trial
#11
T Heller, K Reise, J Roth, T Lehmann, R Schiel, S Lorkowski, U A Müller, N Müller
Background: The JEVIN trial started as a cross-sectional study in 1989/90 in Jena, a city of the former German Democratic Republic. At that time, the centralized diabetes care system was broken down and restarted 10 years later; structured treatment and teaching programs were implemented, blood glucose self-monitoring, insulin pump-systems and analogue insulin were introduced. We surveyed people with type-1-diabetes of the baseline JEVIN trial in a 20-year follow-up. Methods: 131 patients with type-1-diabetes were analyzed in 1989/90...
December 22, 2016: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/27994108/prevalence-of-and-factors-associated-with-nephropathy-in-diabetic-patients-attending-an-outpatient-clinic-in-harare-zimbabwe
#12
Pasipanodya Ian Machingura, Vasco Chikwasha, Parmenas Nelson Okwanga, Exnevia Gomo
There is limited information on the burden of diabetic nephropathy in developing countries. This study aimed to determine the prevalence of and factors associated with nephropathy among diabetic patients attending an outpatient clinic in Harare, Zimbabwe. In an analytical cross-sectional study, diabetic patients were consecutively enrolled and a questionnaire administered, clinical assessment conducted, and blood samples collected for human immunodeficiency virus testing and measurement of lipids, creatinine, fructosamine, and glycosylated hemoglobin levels...
December 19, 2016: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/27993541/diabetes-microvascular-complications-a-clinical-update
#13
REVIEW
H Khalil
BACKGROUND: The purpose of this study is to summarise the empirical evidence addressing diabetes microvascular complications and management. The effects of diabetes mellitus include long-term damage, dysfunction and failure of various organs. Microvascular disease tends to occur predominantly in tissues where glucose uptake is independent of insulin activity because these tissues are exposed to glucose levels that correlate very closely with blood glucose levels. These metabolic injuries cause altered blood flow and changes in endothelial permeability, extravascular protein deposition and coagulation resulting in organ dysfunction which in turn lead to microvascular complications...
December 13, 2016: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/27941053/patient-characteristics-related-to-metabolic-disorders-and-chronic-complications-in-type-2-diabetes-mellitus-patients-hospitalized-at-the-qingdao-endocrine-and-diabetes-hospital-from-2006-to-2012-in-china
#14
Yanhu Dong, Weiguo Gao, Lei Zhang, Jia Wei, Niklas Hammar, Claudia S Cabrera, Xiaoli Wu, Qing Qiao
OBJECTIVE: To study the clinical characteristics related to metabolic disorders and complications in type 2 diabetes mellitus patients hospitalized in the Qingdao Endocrine and Diabetes Hospital from 2006 to 2012 in Qingdao, China. PATIENT POPULATION AND METHODS: Data from 14,289 (51% males) type 2 diabetes mellitus patients hospitalized between 2006 and 2012 were collected and analysed. Information on patients' demographic, anthropometric, laboratory and disease histories were extracted from electronic medical records...
January 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/27940390/impact-of-nonadherence-on-complication-risks-and-healthcare-costs-in-patients-newly-diagnosed-with-diabetes
#15
Haruhisa Fukuda, Miki Mizobe
AIMS: To investigate the association between nonadherence to diabetes treatment and the occurrence of diabetes complications. METHODS: Our study retrospectively identified adherence and nonadherence to diabetes treatment in patients during the first year of observation after new diagnoses of type 2 diabetes enrolled in commercial database from 52 health insurers in Japan. Participants were insurance enrollees with type 2 diabetes who received healthcare between 2005 and 2013, and who could be tracked for more than 12months from the initiation of diabetes treatment...
November 19, 2016: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/27939359/a-story-of-metformin-butyrate-synergism-to-control-various-pathological-conditions-as-a-consequence-of-gut-microbiome-modification-genesis-of-a-wonder-drug
#16
REVIEW
Kunal Maniar, Amal Moideen, Ankur Mittal, Amol Patil, Amitava Chakrabarti, Dibyajyoti Banerjee
The most widely prescribed oral anti-diabetic agent today in the world today is a member of the biguanide class of drugs called metformin. Apart from its use in diabetes, it is currently being investigated for its potential use in many diseases such as cancer, cardiovascular diseases, Alzheimer's disease, obesity, comorbidities of diabetes such as retinopathy, nephropathy to name a few. Numerous in-vitro and in-vivo studies as well as clinical trials have been and are being conducted with a vast amount of literature being published every day...
December 8, 2016: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/27930591/weight-loss-before-a-diagnosis-of-type-2-diabetes-mellitus-is-a-risk-factor-for-diabetes-complications
#17
Shanshan Yang, Shuang Wang, Bo Yang, Jinliang Zheng, Yuping Cai, Zhengguo Yang
Our goal was to investigate the relationship between weight loss before a diagnosis of type 2 diabetes mellitus (T2DM) and diabetic complications among hospitalized patients with T2DM.We conducted a cross-sectional study and evaluated 347 and 642 hospitalized patients with T2DM who experienced and did not experienced weight loss before T2DM diagnosis, respectively. We used propensity score matching to reduce the confounding bias between the groups. In addition, a logistic regression analysis of the matched data was performed to evaluate the risk of diabetic complications...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27923630/association-of-glycated-albumin-to-hba1c-ratio-with-diabetic-retinopathy-but-not-diabetic-nephropathy-in-patients-with-type-2-diabetes
#18
Yutaka Umayahara, Yohei Fujita, Hirotaka Watanabe, Noriko Kasai, Noritaka Fujiki, Masahiro Hatazaki, Masafumi Koga
OBJECTIVES: The ratio of glycated albumin to HbA1c (GA/HbA1c ratio) is a known indicator that reflects fluctuations in plasma glucose. In this study, the association of the GA/HbA1c ratio to diabetic nephropathy and diabetic retinopathy in patients with type 2 diabetes was investigated. DESIGN AND METHODS: Among patients with type 2 diabetes, 613 patients (364 males and 249 females, aged 63.2±12.5, body mass index (BMI) 25.4±4.8kg/m(2)) were enrolled. Patients with overt proteinuria, reduced renal function, or anemia were excluded...
December 5, 2016: Clinical Biochemistry
https://www.readbyqxmd.com/read/27921431/-short-term-and-long-term-glycemic-variability-and-its-relationship-to-microvascular-complications-of-diabetes
#19
Martin Prázný, Jan Škrha, Jan Šoupal, Jan Škrha Jr
Vascular complications of diabetes result from long lasting unsatisfactory glycemic control. We usually assess glycemic control based on the value of glycated hemoglobin HbA1c. The glycated hemoglobin test, however, says nothing about short-term glycemic fluctuations. Recently, continuous monitoring of glycemia has enabled us an in-depth assessment of changes in glucose concentrations, called glycemic variability. In connection with the research into short-term glycemic variability, also the study of long-term fluctuations in glycemic control based on HbA1c variability has now intensified...
2016: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/27921026/a-study-on-the-association-of-diabetic-dermopathy-with-nephropathy-and-retinopathy-in-patients-with-type-2-diabetes-mellitus
#20
Mahmoud Mirhoseini, Nasrin Saleh, Ali Momeni, Fatemeh Deris, Majid Asadi-Samani
BACKGROUND: Diabetic dermopathy is one of the most prevalent skin complications in diabetes patients. Some studies have pointed to association of diabetic dermopathy with retinopathy and nephropathy in patients with type 2 diabetes as microangiopathy presentations, but no rigorous study has been conducted to confirm this association. OBJECTIVES: This study investigated association of diabetic dermopathy with nephropathy and retinopathy in patients with type 2 diabetes referring specialty clinic of Shahrekord...
October 2016: Journal of Nephropathology
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