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diabetic nephropathy and retinopathy

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https://www.readbyqxmd.com/read/28722798/angptl8-betatrophin-role-in-diabetes-and-metabolic-diseases
#1
REVIEW
Mohamed Abu-Farha, Jehad Abubaker, Jaakko Tuomilehto
Diabetes is a major disease worldwide that is reaching epidemic stage. Its increased prevalence as well as its association with a high number of complications such as cardiovascular diseases, nephropathy and retinopathy makes it an important disease for investigation. ANGPTL8 is a recently identified hormone that has been associated with two functionally important processes in the development of type 2 diabetes, insulin resistance as well as lipid metabolism. Initial work has showed that ANGPTL8 was expressed in liver, white adipose and brown adipose tissues...
July 19, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28712629/the-prime-diabetes-model-novel-methods-for-estimating-long-term-clinical-and-cost-outcomes-in-type-1-diabetes-mellitus
#2
William J Valentine, Richard F Pollock, Rhodri Saunders, Jay Bae, Kirsi Norrbacka, Kristina Boye
BACKGROUND: Recent publications describing long-term follow-up from landmark trials and diabetes registries represent an opportunity to revisit modeling options in type 1 diabetes mellitus (T1DM). OBJECTIVES: To develop a new product-independent model capable of predicting long-term clinical and cost outcomes. METHODS: After a systematic literature review to identify clinical trial and registry data, a model was developed (the PRIME Diabetes Model) to simulate T1DM progression and complication onset...
July 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/28710207/comorbidities-complications-and-mortality-in-people-of-south-asian-ethnicity-with-type-1-diabetes-compared-with-other-ethnic-groups-a-systematic-review
#3
Komil N Sarwar, Phoebe Cliff, Ponnusamy Saravanan, Kamlesh Khunti, Krishnarajah Nirantharakumar, Parth Narendran
OBJECTIVE: The aim of this systematic review is to explore the association of South Asian (SA) ethnicity on comorbidities, microvascular and macrovascular complications and mortality compared with other ethnic groups in people with type 1 diabetes mellitus (T1DM). DESIGN: Systematic review. METHOD: A systematic literature search strategy was designed and carried out using Medline and Embase for full-text and abstract studies published in English from 1946 to February 2016...
July 13, 2017: BMJ Open
https://www.readbyqxmd.com/read/28700893/coronary-microvascular-disease-as-an-early-culprit-in-the-pathophysiology-of-diabetes-and-metabolic-syndrome
#4
REVIEW
Hicham Labazi, Aaron J Trask
Metabolic syndrome (MetS) is a group of cardio-metabolic risk factors that includes obesity, insulin resistance, hypertension, and dyslipidemia; these are also a combination of independent coronary artery disease (CAD) risk factors. Alarmingly, the prevalence of MetS risk factors are increasing and a leading cause for mortality. In the vasculature, complications from MetS and type 2 diabetes (T2D) can be divided into microvascular (retinopathy and nephropathy) and macrovascular (cardiovascular diseases and erectile dysfunction)...
July 9, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28670541/occurrence-and-predictors-of-depression-and-poor-quality-of-life-among-patients-with-type-2-diabetes-a-northern-india-perspective
#5
Prerna Bahety, Gunjan Agarwal, Deepak Khandelwal, Deep Dutta, Sanjay Kalra, Pankaj Taparia, Vikas Singhal
BACKGROUND AND AIMS: Globally, depression has been linked to Type-2 diabetes mellitus (T2DM). However, similar data from India are scant. This study evaluated the occurrence and predictors of depression and health-related quality of life (QOL) in patients with T2DM as compared to healthy controls. MATERIALS AND METHODS: One hundred adults with T2DM without prior diagnosis of depression and 100 matched controls were evaluated. Depression was assessed using Patient Health Questionnaire-9...
July 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28667795/dietary-intake-habits-and-prevalence-of-nocturia-in-japanese-patients-with-type-2-diabetes-mellitus
#6
Shinya Furukawa, Takenori Sakai, Tetsuji Niiya, Hiroaki Miyaoka, Teruki Miyake, Shin Yamamoto, Koutatsu Maruyama, Keiko Tanaka, Teruhisa Ueda, Hidenori Senba, Masamoto Torisu, Hisaka Minami, Takeshi Tanigawa, Bunzo Matsuura, Yoichi Hiasa, Yoshihiro Miyake
AIMS/INTRODUCTION: No reports have been published on the association between dietary intake habits and nocturia in the diabetes population. We therefore estimate this issue among Japanese patients with diabetes mellitus. MATERIALS AND METHODS: Study subjects in the present study were 785 Japanese patients with type 2 diabetes mellitus. Self-administrated questionnaires were used to assess each type of dietary intake habits. Vegetable intake habit was assessed by the following question: Do you have vegetables or seaweed every day?" We used the following two outcomes: 1) nocturia: ≥ 2 voids per night and 2) severe nocturia: ≥ 3 voids per night...
July 1, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28662688/ethnic-differences-in-the-405-and-460-vascular-endothelial-growth-factor-polymorphisms-and-peripheral-neuropathy-in-patients-with-diabetes-residing-in-a-north-london-community-in-the-united-kingdom
#7
Karima Zitouni, Lorna Tinworth, Kenneth Anthony Earle
BACKGROUND: There are marked ethnic differences in the susceptibility to the long-term diabetic vascular complications including sensory neuropathy. The vascular endothelial growth factor (VEGF) +405 (C/G) and -460 (T/C) polymorphisms are associated with retinopathy and possibly with nephropathy, however no information is available on their relationship with peripheral neuropathy. Therefore, we examined the prevalence of these VEGF genotypes in a multi-ethnic cohort of patients with diabetes and their relationship with evident peripheral diabetic neuropathy...
June 29, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28649285/introduction-of-the-diagene-study-clinical-characteristics-pathophysiology-and-determinants-of-vascular-complications-of-type-2-diabetes
#8
Thijs T W van Herpt, Roosmarijn F H Lemmers, Mandy van Hoek, Janneke G Langendonk, Ronald J Erdtsieck, Bert Bravenboer, Annelies Lucas, Monique T Mulder, Harm R Haak, Aloysius G Lieverse, Eric J G Sijbrands
BACKGROUND: Type 2 diabetes is a major healthcare problem. Glucose-, lipid-, and blood pressure-lowering strategies decrease the risk of micro- and macrovascular complications. However, a substantial residual risk remains. To unravel the etiology of type 2 diabetes and its complications, large-scale, well-phenotyped studies with prospective follow-up are needed. This is the goal of the DiaGene study. In this manuscript, we describe the design and baseline characteristics of the study...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/28637729/incidence-of-diabetes-related-complications-in-chinese-patients-with-type-1-diabetes-a-population-based-longitudinal-cohort-study-in-taiwan
#9
Huang-Tz Ou, Tsung-Ying Lee, Chung-Yi Li, Jin-Shang Wu, Zih-Jie Sun
OBJECTIVE: To estimate the incidence densities and cumulative incidence of diabetes-related complications in patients with type 1 diabetes for a maximum of 15-year follow-up. The estimations were further stratified by gender and age at diagnosis (ie, early onset: 0-12 years, late onset:≥13 years). DESIGN: A population-based retrospective longitudinal cohort study. SETTING: Taiwan's National Health Insurance medical claims. PARTICIPANTS: 4007 patients newly diagnosed with type 1 diabetes were identified during 1999-2012...
June 21, 2017: BMJ Open
https://www.readbyqxmd.com/read/28618325/early-short-term-intensive-multidisciplinary-diabetes-care-a-ten-year-follow-up-of-outcomes
#10
Zhong Zhi Shen, Yu Yao Huang, Ching Jung Hsieh
OBJECTIVES: To evaluate the outcome of an early short-term intensive diabetic care program followed by a regular out-patient shared-care education program. METHODS: We retrospectively reviewed the medical charts of 196 patients newly diagnosed with type 2 diabetes mellitus (DM) who were admitted to the hospital for intensive multidisciplinary interventions. For comparison, we also enrolled 206 patients with type 2 DM newly diagnosed but not receiving short-term intensive program...
June 2, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28611649/a-case-of-diabetic-macular-edema-with-prominent-chorioretinal-folds
#11
Takaki Sato, Ryohsuke Kohmoto, Masanori Fukumoto, Seita Morishita, Daisaku Kimura, Kensuke Tajiri, Takatoshi Kobayashi, Teruyo Kida, Shota Kojima, Tsunehiko Ikeda
PURPOSE: To report a case of diabetic macular edema with prominent chorioretinal folds. CASE REPORT: This study involved a 55-year-old male with untreated bilateral diabetic retinopathy who had undergone cataract surgery at another clinic. Following that surgery, diabetic macular edema rapidly exacerbated, accentuating marked cystoid macular edema and radial chorioretinal folds in the macula. Investigation of his medical history revealed that in addition to diabetes, he had uncontrolled hypertension and severe diabetic nephropathy...
January 2017: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/28601068/prevalence-of-autoantibodies-against-3-dg-glycated-h2a-protein-in-type-2-diabetes
#12
J M Ashraf, S M S Abdullah, S Ahmad, S Fatma, M H Baig, J Iqbal, A M Madkhali, A B A Jerah
Advanced glycation end-products (AGEs) have been found to be critically involved in initiation or progression of diabetes secondary complications (nephropathy, retinopathy, neuropathy, and angiopathy). Various hyper-glycating carbonyl compounds such as 3-deoxyglucosone (3-DG) are produced in pathophysiological conditions that form AGEs in high quantity both in vivo and in vitro. In the first stage of this study, we glycated histone H2A protein by 3-DG, and the results showed the formation of various intermediates and AGEs as well as structural changes in the protein...
May 2017: Biochemistry. Biokhimii︠a︡
https://www.readbyqxmd.com/read/28599823/neuropathy-and-presence-of-emotional-distress-and-depression-in-longstanding-diabetes-results-from-the-canadian-study-of-longevity-in-type-1-diabetes
#13
Johnny-Wei Bai, Leif E Lovblom, Marina Cardinez, Alanna Weisman, Mohammed A Farooqi, Elise M Halpern, Genevieve Boulet, Devrim Eldelekli, Julie A Lovshin, Yuliya Lytvyn, Hillary A Keenan, Michael H Brent, Narinder Paul, Vera Bril, David Z I Cherney, Bruce A Perkins
AIM: To determine the association of neuropathy and other complications with emotional distress and depression among patients with longstanding type 1 diabetes (T1DM). METHODS: Canadians with ≥50years of T1DM completed a questionnaire including assessment of distress and depression by the Problem Areas in Diabetes Scale (PAID) and Geriatric Depression Scale (GDS), respectively. Complications were determined using the Michigan Neuropathy Screening Instrument (Questionnaire Component), fundoscopy reports, renal function tests, and self-reported peripheral-(PVD) and cardiovascular (CVD) disease...
May 10, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28598042/peripheral-vascular-disease-in-patients-with-diabetic-foot-ulcers-an-emerging-trend-a-prospective-study-from-north-india
#14
Supriya Bajaj, Amit Mahajan, Sumit Grover, Vijay Mahajan, Pankaj Goyal, Vikram Kumar Gupta
BACKGROUND: Diabetic foot ulcer is one of the chronic complications of diabetes mellitus (DM) with 25% of patients with diabetes developing a foot ulcer during their lifetime leading to amputation. Diabetic foot is classified into 2 main types: neuropathic ulcers (NPU) and neuro-ischemic ulcer (NIU) where in addition to neuropathy peripheral vascular disease (PVD) is also present. AIMS: We aimed to a) assess the prevalence of Peripheral vascular disease (PVD) in patients of type 2 diabetes mellitus (T2DM) presenting with New Diabetic Foot ulcers (DFU)...
May 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/28585130/factors-associated-with-peripheral-neuropathy-in-type-2-diabetes-subclinical-versus-confirmed-neuropathy
#15
Yogendranathsing Unmar, Mohammad Ishraq Zafar, Feng Gao
This study determined the prevalence of diabetic peripheral neuropathy (DPN) and subclinical DPN (sDPN) in patients with type 2 diabetes mellitus (T2DM) using nerve conduction study (NCS) as a diagnostic tool. We also investigated the factors associated with the development of sDPN and compared factors between the sDPN and confirmed DPN (cDPN). This cross-sectional study involved 240 T2DM patients who were successively admitted to the endocrinology wards of Wuhan Union Hospital over the period of January to December 2014...
June 2017: Journal of Huazhong University of Science and Technology. Medical Sciences
https://www.readbyqxmd.com/read/28579862/assessment-of-hypogonadism-in-men-with-type-2-diabetes-a-cross-sectional-study-from-saudi-arabia
#16
Ayman Abdullah Al Hayek, Asirvatham Alwin Robert, Ghazi Alshammari, Husain Hakami, Mohamed Abdulaziz Al Dawish
BACKGROUND/OBJECTIVES: A high incidence of hypogonadism in men with type 2 diabetes (T2D) has been globally reported. This study aimed to determining the frequency of hypogonadism and related risk factors among men with T2D in a single-site hospital in Saudi Arabia. DESIGN AND METHODS: A cross-sectional study was performed on 157 men with T2D (between 30 and 70 years of age). Using a prestructured questionnaire, the demographic features of these patients were gathered and their medical records were referred to gather information regarding the duration of the diabetes, smoking habits, and the presence of retinopathy, neuropathy, and nephropathy...
2017: Clinical Medicine Insights. Endocrinology and Diabetes
https://www.readbyqxmd.com/read/28574296/prediction-of-preeclampsia-in-type-1-diabetes-in-early-pregnancy-by-clinical-predictors-a-systematic-review
#17
Marianne Vestgaard, Miriam Colstrup Sommer, Lene Ringholm, Peter Damm, Elisabeth R Mathiesen
PURPOSE: The purpose of this study is to evaluate the prevalence and possible clinical predictors of preeclampsia present in early pregnancy among women with type 1 diabetes. METHODS: A systematic search of PubMed was conducted in April 2017. Inclusion criteria were largely unselected cohort, including at least 100 women with type 1 diabetes, dealing with either the prevalence of preeclampsia or possible clinical predictors of preeclampsia identified in early pregnancy...
June 2, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28559931/soluble-plasma-proteins-st2-and-cd163-as-early-biomarkers-of-nephropathy-in-swedish-patients-with-diabetes-15-34%C3%A2-years-of-age-a-prospective-cohort-study
#18
My Samuelsson, Jonatan Dereke, Maria K Svensson, Mona Landin-Olsson, Magnus Hillman
BACKGROUND: The aim of this study was to investigate plasma levels of sST2 and sCD163 to determine whether they at an early stage could predict development of diabetic nephropathy and/or diabetic retinopathy in patients at clinical onset. METHODS: Patients diagnosed with diabetes mellitus at age 15-34 years between 1987 and 1988 (n = 220) were included. Data such as BMI, smoking, HbA1c and islet cell antibodies were collected at time of diagnosis. Within the 10 year follow-up period, 112 patients (51%) developed following diabetes related complications; retinopathy (n = 91), nephropathy (n = 12) or both (n = 9)...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/28552652/blood-pressure-management-in-patients-with-diabetes-insights-from-the-diabetes-mellitus-status-in-canada-survey
#19
Jasmine Grenier, Shaun G Goodman, Lawrence A Leiter, Anatoly Langer, Hwee Teoh, Deepak L Bhatt, Alice Y Y Cheng, Mary K Tan, Thomas Ransom, Kim A Connelly, Andrew T Yan
OBJECTIVES: Optimal treatment of blood pressure (BP) and other cardiovascular risk factors, including hyperglycemia, is integral to diabetes management. There are limited data from the primary care setting concerning the contemporary and comprehensive management of type 2 diabetes and other cardiovascular risk factors in relation to guideline-recommended BP target achievement. METHODS: The Diabetes Mellitus Status in Canada (DM-SCAN) survey included 5172 ambulatory patients with type 2 diabetes...
May 25, 2017: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/28552218/epigenetics-and-type-1-diabetes-mechanisms-and-translational-applications
#20
REVIEW
Alberto Zullo, Linda Sommese, Gianfranco Nicoletti, Francesco Donatelli, Francesco P Mancini, Claudio Napoli
Type 1 diabetes (T1D) is an irreversible degenerative disease with severe complications such as heart disease, nephropathy, neuropathy, and retinopathy. Although exogenous insulin administration is a life-saving therapy, it does not cure the disease. This review addresses the epigenetic mechanisms responsible for the development of T1D and discusses epigenetic-based strategies for prevention and treatment of the disease. We describe novel epigenetic biomarkers for the identification of susceptible individuals and the establishment of innovative therapies with epidrugs and cell therapy to regenerate the lost β-cells...
July 2017: Translational Research: the Journal of Laboratory and Clinical Medicine
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