Xiuli Zhang, Gyu Seong Heo, Alexandria Li, Divangana Lahad, Lisa Detering, Joan Tao, Xuefeng Gao, Xiaohui Zhang, Hannah Luehmann, Deborah Sultan, Lanlan Lou, Rajiu Venkatesan, Ran Li, Jie Zheng, Junedh Amrute, Chieh-Yu Lin, Benjamin J Kopecky, Robert J Gropler, Andrea Bredemeyer, Kory Lavine, Yongjian Liu
Tissue-resident macrophages are complementary to proinflammatory macrophages to promote the progression of atherosclerosis. The noninvasive detection of their presence and dynamic variation will be important to the understanding of their role in the pathogenesis of atherosclerosis. The goal of this study was to develop a targeted PET radiotracer for imaging CD163-positive (CD163+) macrophages in multiple mouse atherosclerosis models and assess the potential of CD163 as a biomarker for atherosclerosis in humans...
March 28, 2024: Journal of Nuclear Medicine