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https://www.readbyqxmd.com/read/29045981/renal-ewing-s-sarcoma-primitive-neuroectodermal-tumor-a-case-report-and-literature-review
#1
C Liu, L G Cui, H L Wang
Ewing's sarcoma/primitive neuroectodermal tumor (EWS/PNET) in the kidney is a rare but high-grade malignant tumor that affects predominantly elder children and adolescents. Patients mostly present with nonspecific symptoms such as abdominal pain and gross hematuria. Since EWS/PNET has a rapid clinical progression with early metastasis and death, it is essential to make an accurate and early diagnosis. Once diagnosed, multimodality treatment, including radical surgery combined with adjuvant chemotherapy, and radiotherapy if necessary, is recommended...
October 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/29045340/cause-of-renal-infarction-a-retrospective-analysis-of-186-consecutive-cases
#2
Anne-Laure Faucon, Guillaume Bobrie, Anne-Sophie Jannot, Arshid Azarine, Pierre-François Plouin, Michel Azizi, Laurence Amar
BACKGROUND: Renal infarction can cause abrupt and severe hypertension and less frequently renal failure. Renal infarction results from disruption of renal blood flow in the main ipsilateral renal artery or in a segmental branch. Underlying mechanism is either general, 'embolic' or 'thrombophilic', or local related to primary 'renal artery lesion'. It depends on various causes. In absence of an identified cause, renal infarction is classified as 'idiopathic'. Previous studies report a significant number of 'idiopathic' renal infarction...
October 16, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/29041878/-influence-of-sympathetic-denervation-of-the-renal-artery-on-the-level-of-arterial-blood-pressure-cerebral-blood-flow-and-cognitive-function-in-patients-with-resistant-arterial-hypertension
#3
Y N Efimova, A V Lichikaki, B Y Lishmanov
PURPOSE: To study the effect of radiofrequency ablation of renal arteries on regional cerebral blood flow and cognitive function in patients with resistant arterial hypertension (AH). MATERIAL AND METHODS: Transcatheter renal denervation (TRD) was performed in 17 patients with resistant AH. Examination before and after TRD included SPECT with mTc-HMPAO, 24-hours blood pressure (BP) monitoring, and comprehensive neuropsychological testing. Fifteen patients without angiographic signs of carotid atherosclerosis, coronary artery disease and AH, neurological and psychiatric disorders were investigated as control group...
July 2017: Kardiologiia
https://www.readbyqxmd.com/read/29040297/decreased-nk-cell-immunity-in-kidney-transplant-recipients-late-post-transplant-and-increased-nk-cell-immunity-in-patients-with-recurrent-miscarriage
#4
Li Zhu, Mostafa Aly, Haihao Wang, Hristos Karakizlis, Rolf Weimer, Christian Morath, Ruben Jeremias Kuon, Bettina Toth, Gerhard Opelz, Volker Daniel
BACKGROUND: There is evidence that NK-cell reactivity might affect graft outcome in transplant recipients and pregnancy in women. METHOD: NK-cell subsets were determined in whole blood using eight-colour-fluorescence flow cytometry in patients before and after renal transplantation, patients with recurrent miscarriage (RM) and healthy controls (HC). RESULTS: Patients late post-transplant (late-Tx) with functioning renal transplants showed abnormally low CD56dimCD16+ NK-cells containing both perforin and granzyme (vs HC p = 0...
2017: PloS One
https://www.readbyqxmd.com/read/29032314/remodeling-of-arterial-wall-response-to-changes-in-both-blood-flow-and-blood-pressure
#5
Kozaburo Hayashi, Akihisa Makino, Daichi Kakoi
Many studies have been performed on arterial responses to chronic changes in blood flow (BF) and blood pressure (BP). However, little is known about the effects of simultaneous changes in BF and BP. The present study was carried out to know biomechanical responses of arterial wall to the combination of increased BP, i.e. hypertension (HT), with lower or higher BF than normal, and the results were compared with those observed under normal BP, i.e. normotension (NT), combined with these BF conditions. Eight weeks old rats were subjected to BF and/or BP changes for 8 weeks until 16 weeks of age...
October 7, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29023893/analysis-of-renal-blood-flow-and-renal-volume-in-normal-fetuses-and-in-fetuses-with-a-solitary-functioning-kidney
#6
An Hindryckx, Anke Raaijmakers, Elena Levtchenko, Karel Allegaert, Luc De Catte
OBJECTIVE: To evaluate renal blood flow and renal volume for the prediction of postnatal renal function in fetuses with solitary functioning kidney (SFK). METHODS: 74 SFK fetuses (unilateral renal agenesis (12), multicystic dysplastic kidney (36) and severe renal dysplasia (26)) were compared with 58 healthy fetuses. Peak systolic velocity (PSV), Pulsatility Index (PI ) and Resistance Index (RI) of the renal artery (RA) were measured; 2- and 3D (VOCAL) volumes were calculated...
October 10, 2017: Prenatal Diagnosis
https://www.readbyqxmd.com/read/29023738/klf2-mediates-enhanced-chemoreflex-sensitivity-disordered-breathing-and-autonomic-dysregulation-in-heart-failure
#7
Noah J Marcus, Rodrigo Del Rio, Yanfeng Ding, Harold D Schultz
KEY POINTS: Enhanced carotid body chemoreflex activity contributes to development of disordered breathing patterns, autonomic dysregulation and increases in incidence of arrhythmia in animal models of reduced ejection fraction heart failure. Chronic reductions in carotid artery blood flow are associated with increased carotid body chemoreceptor activity. Krüppel-like Factor 2 (KLF2) is a shear stress-sensitive transcription factor that regulates the expression of enzymes which have previously been shown to play a role in increased chemoreflex sensitivity...
September 6, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/29018183/a-case-of-left-renal-vein-ligation-in-a-patient-with-solitary-left-kidney-undergoing-liver-transplantation-to-control-splenorenal-shunt-and-improve-portal-venous-flow
#8
Rodrigo B Martino, Eserval Rocha Júnior, Valdano Manuel, Vinicius Rocha-Santos, Luis Augusto C D'Albuquerque, Wellington Andraus
BACKGROUND Adequate portal venous flow is required for successful liver transplantation. Reduced venous flow and blood flow 'steal' by collateral vessels are a concern, and when there is a prominent splenorenal shunt present, ligation of the left renal vein has been recommended to improve portal venous blood flow. CASE REPORT A 51-year-old man who had undergone right nephrectomy in childhood required liver transplantation for liver cirrhosis and hepatocellular carcinoma due to hepatitis C virus (HCV) infection...
October 11, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28991824/the-%C3%AE-blocker-esmolol-restores-the-vascular-waterfall-phenomenon-after-acute-endotoxemia
#9
Wei Du, Dawei Liu, Yun Long, Xiaoting Wang
BACKGROUND: A vascular waterfall occurs when the critical closing pressure is greater than the mean systemic filling pressure. Because the waterfall phenomenon likely exists in the microcirculation, β1-receptor blockers such as esmolol could have some effect on microcirculation and vascular waterfall. OBJECTIVES: To determine whether a vascular waterfall exists during septic shock and to assess the effects of vasopressors and β-blockers on vascular waterfall. DESIGN: Sixteen mongrel dogs were mounted with ultrasonic flow probes to measure renal blood flow...
October 6, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28986330/renal-and-femoral-venous-blood-flows-are-regulated-by-different-mechanisms-dependent-on-%C3%AE-adrenergic-receptor-subtypes-and-nitric-oxide-in-anesthetized-rats
#10
Alexandre C Fioretti, Cristiana A Ogihara, Eduardo M Cafarchio, Daniel P Venancio, Roberto Lopes de Almeida, Bruno B Antonio, Monica A Sato
Venous and arterial walls are responsive to sympathetic system and circulating substances, nevertheless, very few is known about the venous blood flow regulation simultaneously to arterial vascular beds. In this study, we compared the venous and arterial blood flow regulation in visceral and muscular beds upon injection of different doses of vasoactive drugs which act in arterial vascular beds. Anesthetized adult male Wistar rats underwent to right femoral artery and vein cannulation for hemodynamic recordings and infusion of drugs...
October 3, 2017: Vascular Pharmacology
https://www.readbyqxmd.com/read/28985850/the-administration-of-argon-during-ex-vivo-normothermic-perfusion-in-an-experimental-model-of-kidney-ischemia-reperfusion-injury
#11
Stephanie F Smith, Thomas Adams, Sarah A Hosgood, Michael L Nicholson
BACKGROUND: Argon has shown potential as an organoprotective agent in numerous models of ischemia-reperfusion injury (IRI). The aim of this study was to evaluate the effects of argon gas during ex vivo normothermic perfusion (EVNP) in an experimental porcine model of kidney IRI. MATERIALS AND METHODS: After a warm ischemia time of 15 min and 17 h of static cold storage, porcine kidneys underwent 1 h of EVNP using leukocyte-depleted blood. During EVNP, kidneys were perfused with a gas composition either of 70% argon (n = 6), 70% nitrogen control (n = 6), or standard 95% oxygen (n = 6) balanced with 5% carbon dioxide...
October 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28985335/current-concepts-in-the-treatment-of-renovascular-hypertension
#12
Sandra M Herrmann, Stephen C Textor
Renovascular disease remains a major cause of secondary and treatment-resistant hypertension. Most cases are related either to fibromuscular or atherosclerotic lesions, but a variety of other causes including arterial dissection, stent occlusion and embolic disease can produce the same syndrome. Recent studies emphasize the kidney's tolerance to moderate flow reduction during antihypertensive drug therapy and the relative safety of medical therapy to control blood pressure. Several prospective trials in moderate renovascular disease fail to identify major benefits from endovascular revascularization for moderate atherosclerotic disease...
August 16, 2017: American Journal of Hypertension
https://www.readbyqxmd.com/read/28982622/retroperitoneal-compartment-syndrome-in-renal-transplantation-how-to-salvage-the-graft
#13
Karen Pineda-Solís, Wen Yan Xie, Vivian McAlister, Alp Sener, Patrick P Luke
OBJECTIVE: Early allograft dysfunction may be caused by several technical factors including vascular complications such as thrombosis, kinking, or extrinsic compression. Renal allograft compartment syndrome (RACS) is an unrecognized cause of early allograft dysfunction. This complication is characterized by increased pressure of the iliac fossa that reduces the blood supply to the graft with a potentially devastating consequence. The main objective when recognizing this condition is to create a tension-free muscle closure...
September 2017: Urology
https://www.readbyqxmd.com/read/28980339/prorenin-receptor-mediates-inflammation-in-renal-ischemia
#14
Syed S Quadri, Silas Culver, Helmy M Siragy
We hypothesized that PRR contributes to renal inflammation in the 2-kidney, 1-clip (2K1C) renal ischemia model. Male Sprague-Dawley rats were fed normal sodium diet. BP was obtained on day 0 and 28 after left renal artery clipping that reduced renal blood flow by 40%. Renal expression of TNF-α, COX-2, NF-κB, IL-1β, MCP-1 and collagen type I were assessed in sham and 2K1C rats with or without left renal administration of scramble or PRR shRNA. At baseline, there were no differences in BP. Compared to sham, MAP significantly increased in clipped animals (sham: 102± 1...
October 5, 2017: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/28978536/the-role-of-tlr4-signaling-in-the-nephrotoxicity-of-heme-and-heme-proteins
#15
Karl A Nath, John D Belcher, Meryl C Nath, Joseph P Grande, Anthony J Croatt, Allan W Ackerman, Zvonimir S Katusic, Gregory M Vercellotti
Destabilized heme proteins release heme, and free heme is toxic. Heme is now recognized as an agonist for the TLR4 receptor. This study examined whether the TLR4 receptor mediates the nephrotoxicity of heme, specifically, the effects of heme on renal blood flow and inflammatory responses. We blocked TLR4 signaling by the specific antagonist TAK-242. Intravenous administration of heme to mice promptly reduced renal blood flow, an effect attenuated by TAK-242. In vitro, TAK-242 reduced heme-elicited activation of NF-κB and its downstream gene MCP-1; in contrast, TAK-242 failed to reduce heme-induced activation of the anti-inflammatory transcription factor, Nrf2, and its downstream gene HO-1...
October 4, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28978533/non-invasive-measurement-of-renal-blood-flow-by-magnetic-resonance-imaging-mri-in-rats
#16
Cesar A Romero, Glauber Cabral, Robert A Knight, Guangliang Ding, Edward L Peterson, Oscar A Carretero
Renal blood flow (RBF) provides important information regarding renal physiology and nephropathies. Arterial spin labeling-magnetic resonance imaging (ASL-MRI) is a non-invasive method of measuring blood flow without exogenous contrast media. However, low signal/noise ratio and respiratory motion artifacts are challenges for RBF measurements in small animals. Our objective was to evaluate the feasibility and reproducibility of RBF measures by ASL-MRI using respiratory-gating and navigator correction methods to reduce motion artifacts...
October 4, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28978531/effects-of-serelaxin-on-renal-microcirculation-in-rats-under-control-and-high-angiotensin-environments
#17
Weijian Shao, Carla B Rosales, Camila Gonzalez, Minolfa C Prieto, L Gabriel Navar
Serelaxin is a novel recombinant human relaxin-2 that has been investigated for the treatment of acute heart failure. However, its effects on renal function, especially on the renal microcirculation remain incompletely characterized. Our immunoexpression studies localized RXFP1 receptors on vascular smooth muscle cells and endothelial cells of afferent arterioles and on principal cells of collecting ducts. Clearance experiments were performed in male and female normotensive rats and Ang II infused male rats...
October 4, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28967060/original-flow-chart-for-the-management-of-hydroureteronephrosis-caused-by-pessary-placement
#18
Matteo Balzarro, Emanuele Rubilotta, Antonio B Porcaro, Nicolò Trabacchin, Antonio D'Amico, Maria Angela Cerruto, Walter Artibani
INTRODUCTION: The use of a pessary to treat a pelvic organ prolapse (POP) is a valid non-invasive option. Severe complications are usually associated with neglected, oversized, or misplaced pessaries. Major complications include fistulas, bowel or bladder erosion, and hydroureteronephrosis (HUN). MATERIALS AND METHODS: We reviewed the literature and our experience in the management of HUN in the last decade, as a consequence of pessary placement. RESULTS: We used flow charts to take an accurate medical history of each patient...
September 9, 2017: Urologia
https://www.readbyqxmd.com/read/28963441/pathological-significance-and-regulatory-mechanism-of-lymphotoxin-%C3%AE-receptor-overexpression-in-t-cells-of-patients-with-systemic-lupus-erythematosus
#19
Cheng Yin, Xu-Bing Cai, Hui-Juan Wang, Bing-Jie Gu, Xiao-Fan Yang, Rong Zhang, Xiao-Hui Ji
Systemic lupus erythematosus (SLE) is a typical autoimmune disease. Lymphotoxin β receptor (LTβR) signaling plays an important role in autoimmune inflammations. LTβR-Ig fusion protein, LTβR blocking agent, has been used to treat SLE, while its mechanism remains to be fully elucidated. In this study, to investigate the expression of LTβR in the T cells of SLE patients and its roles in the pathogenesis of SLE, we isolated the peripheral blood T cells of SLE patients and normal controls to detect expression of LTβR by flow cytometry and RNA assay...
September 30, 2017: Journal of Biomedical Research
https://www.readbyqxmd.com/read/28959212/multiparametric-renal-magnetic-resonance-imaging-validation-interventions-and-alterations-in-chronic-kidney-disease
#20
Eleanor F Cox, Charlotte E Buchanan, Christopher R Bradley, Benjamin Prestwich, Huda Mahmoud, Maarten Taal, Nicholas M Selby, Susan T Francis
Background: This paper outlines a multiparametric renal MRI acquisition and analysis protocol to allow non-invasive assessment of hemodynamics (renal artery blood flow and perfusion), oxygenation (BOLD T2(*)), and microstructure (diffusion, T1 mapping). Methods: We use our multiparametric renal MRI protocol to provide (1) a comprehensive set of MRI parameters [renal artery and vein blood flow, perfusion, T1, T2(*), diffusion (ADC, D, D(*), fp), and total kidney volume] in a large cohort of healthy participants (127 participants with mean age of 41 ± 19 years) and show the MR field strength (1...
2017: Frontiers in Physiology
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