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JOURNAL ARTICLE
Alfonso Gastelum-Strozzi, Diana Elsa Flores-Alvarado, Virginia Pascual-Ramos, Everardo Álvarez-Hernández, César Francisco Pacheco-Tena, Guillermo Arturo Guaracha-Basáñez, Conrado García García, Susana Aideé González-Chávez, José Francisco Moctezuma-Ríos, Amaranta Manrique de Lara, Jorge Antonio Esquivel-Valerio, Irazú Contreras-Yáñez, Dionicio Ángel Galarza-Delgado, Janitzia Vázquez-Mellado, Ingris Peláez-Ballestas, Greta Cristina Reyes-Cordero
The attitudes toward emerging COVID-19 vaccines have been of great interest worldwide, especially among vulnerable populations such as patients with rheumatic and musculoskeletal diseases (RMDs). The aim of this study was to analyze the relationship between the nationwide number of COVID-19 cases and deaths, and vaccine acceptance or hesitancy of patients with RMDs from four patient care centers in Mexico. Furthermore, we explored differences in acceptance according to specific diagnoses: rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE)...
May 2, 2023: Rheumatology International
#22
JOURNAL ARTICLE
Luis Alonso González, Graciela S Alarcón, Guillermina B Harvey, Rosana Quintana, Guillermo J Pons-Estel, Manuel F Ugarte-Gil, Gloria Vásquez, Luis J Catoggio, Mercedes A García, Eduardo F Borba, Nilzio A Da Silva, João C Tavares Brenol, Marlene Guibert Toledano, Loreto Massardo, Oscar Neira, Virginia Pascual-Ramos, Mary-Carmen Amigo, Leonor A Barile-Fabris, Ignacio García De La Torre, José Alfaro-Lozano, María I Segami, Rosa Chacón-Díaz, María H Esteva-Spinetti, Antonio Iglesias-Gamarra, Bernardo A Pons-Estel
OBJECTIVE: To determine the predictors of the occurrence of severe autoimmune hemolytic anemia (AIHA) and its impact on damage accrual and mortality in SLE patients. METHODS: Factors associated with time to severe AIHA (hemoglobin level ≤7 g/dL) occurring from the onset of SLE symptoms were examined by Cox proportional hazards regressions. The association of severe AIHA with mortality was examined by logistic regression analyses while its impact on damage was by negative binomial regression...
April 2023: Lupus
#23
Rodrigo Sabio, Pascual Valdez, María Natalia Nachón, Claudia Arias, Carlos Nitsch Montiel, Eduardo Penny, Felipe Melgar Cuellar, Carlos Araya Fonseca, Ruben Montúfar Guardado, Águeda Cotignola, Andrea Odzak, Jorge Franchella, Aland Bisso, Maritza Duran, Rodolfo Palencia Vizcarra, Ricardo Gómez Huelgas, Wesley Rodríguez, Hugo Milione, Roberto Parodi, Emilio Buchaca Faxas, Luis Rojas Orellana, María Lucía Fortuna Peralta, Cinthia Coral Cristaldo, José Ortellado, Jesús Diez Manglano, Juan Barrios, María Cristina Jiménez, James Gutiérrez Tudela, Gustavo Bruno, Jorge Contreras Mónchez, Silvio Payaslián, Javier Pollán, Helí Hernández, Andrea Vaucher, Isis Betancourt, Helga Codina, Hugo Celauro, Silvia Cortese, Marina Risso, Homero Puello, Emilio Casariego, Lorenzo Díaz Salazar, Rosalía García Peña, Sonia Indacochea-Cáceda, Luis García-Carrión, Evelyn Murillo Salvatierra, Matías Mirofsky, Gabriela Andrade, Adolfo Savia, Paula Canda, Alejandro Cárdenas, Diana Rodríguez Hurtado, Monserrat Chimeno Viñas, Mario Patiño, Rubén Gómez Mendoza, Gustavo Arbo, Horacio J Romano, Alejandra Sánchez Cabezas, Yazmín Abuabara Turbay, Roxana Hiza, Luis Campos, María Do Patrocinio Tenorio Nunes, Lelita Santos, Virginia Salazar Matos, Tatiana Espinosa, Jorge González Ruiz Díaz, Santiago Carrasco, Adriana Romani, Lourdes Escalera, Rodolfo Palencia Díaz, Gabriela Giaccaglia, Jose Galarza Nuñez, Pilar Román Sánchez, Mariana Costanzo, Sandra Garay Tamara, Jorge Rodriguez García, Oscar Bellini, Alberto Ruiz Cantero, Luis Cámera, Miguel Serra Valdés, Raul Ledesma, Miguel Blanco Aspiazu, Altagracia Mejía Terrero, José Javier Arango Álvarez, Karen Elizabeth Cárcamo De Villatoro, Omar Castillo Fernández, Raquel Monteghirfo, Carlos Galarza, Federico Somoza, Alejandro Schejtman, Bismarck Perez, Agustina Marconi, Alfredo Cabrera Rayo
Cardiovascular diseases (CVD), mainly ischemic heart disease and stroke, is the main cause of death worldwide and each year more people die from CVD than from any other cause. These data call for a paradigm shift, where health promotion and cardiovascular prevention will acquire a central role in health policies. From this perspective, dedicating time during the consultation to promoting the acquisition of heart-healthy habits would be indicated in all individuals, regardless of cardiovascular risk classification, the role of the internist being fundamental...
January 10, 2023: Medicina
#24
JOURNAL ARTICLE
Jacqueline Gofshteyn, Leanne Mansfield, Jacob Spitznagle, Preetha Balasubramanian, Jacob Cardenas, Thomas Miller, Jinghua Gu, Xuan Wang, Marilynn Punaro, Julie Fuller, Lorien Nassi, Katie Stewart, Marina Ohouo, Cristy Stagnar, Jeanine Baisch, Lynnette Walters, Yuanyuan Wang, Helena Yan, Darawan Rinchai, Damien Chaussabel, Simone Caielli, Seunghee Hong, Karen Onel, Tracey Wright, Virginia Pascual
OBJECTIVES: To identify markers of Juvenile Dermatomyositis (JDM) disease activity (DA), which are needed to improve disease management. METHODS: 123 JDM patients and 53 healthy controls (HC) were included in the study. Laboratory tests (aldolase, CK, LDH, AST) and clinical measures of DA, including the Manual Muscle Testing (MMT-8), Childhood Myositis Assessment Scale (CMAS), and Disease Activity Scores (DAS), were recorded when available. Surface phenotype of peripheral blood mononuclear cells (PBMCs) was assessed using flow cytometry...
January 17, 2023: Arthritis & Rheumatology
#25
JOURNAL ARTICLE
José R Galindo-Donaire, Gabriela Hernández-Molina, Ana Fresán Orellana, Irazú Contreras-Yáñez, Guillermo Guaracha-Basáñez, Oswaldo Briseño-González, Virginia Pascual-Ramos
BACKGROUND: Rheumatoid arthritis (RA) patients commonly report medicinal cannabis use (MCU). Personality has been independently associated with both RA-related outcomes and MCU, but there is no information available on how they interact in RA patients. This study aimed to investigate a potential association between personality traits and MCU in RA outpatients, as well as to identify additional factors associated with its use. METHODS: This cross-sectional study was performed between June 2020 and August 2021...
2023: PloS One
#26
JOURNAL ARTICLE
Ana Belén Ortiz-Haro, Irazú Contreras-Yáñez, Guillermo Guaracha-Basáñez, Virginia Pascual-Ramos
BACKGROUND: Little attention has been given to the impact of rheumatoid arthritis (RA) on domestic work, which remains the domain of women, particularly in the Latin American region. The study identified factors associated with RA-related household work limitations (HOWL) in Mexican for women with long-standing disease. METHODS: This cross-sectional study was performed between September 2020 and April 2022, in patients from the recent-onset RA cohort (initiated in 2004)...
January 10, 2023: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
#27
JOURNAL ARTICLE
mTORC1 links pathology in experimental models of Still's disease and macrophage activation syndrome.
Zhengping Huang, Xiaomeng You, Liang Chen, Yan Du, Kailey Brodeur, Hyuk Jee, Qiang Wang, Grace Linder, Roxane Darbousset, Pierre Cunin, Margaret H Chang, Alexandra Wactor, Brian M Wauford, Marc J C Todd, Kevin Wei, Ying Li, Anais Levescot, Yoichiro Iwakura, Virginia Pascual, Nicole E Baldwin, Pierre Quartier, Tianwang Li, Maria T Gianatasio, Robert P Hasserjian, Lauren A Henderson, David B Sykes, Elizabeth D Mellins, Scott W Canna, Julia F Charles, Peter A Nigrovic, Pui Y Lee
Still's disease is a severe inflammatory syndrome characterized by fever, skin rash and arthritis affecting children and adults. Patients with Still's disease may also develop macrophage activation syndrome, a potentially fatal complication of immune dysregulation resulting in cytokine storm. Here we show that mTORC1 (mechanistic target of rapamycin complex 1) underpins the pathology of Still's disease and macrophage activation syndrome. Single-cell RNA sequencing in a murine model of Still's disease shows preferential activation of mTORC1 in monocytes; both mTOR inhibition and monocyte depletion attenuate disease severity...
November 28, 2022: Nature Communications
#28
JOURNAL ARTICLE
Jessica Cuartero, Jose Antonio Pascual, Juana-María Vivo, Onurcan Özbolat, Virginia Sánchez-Navarro, Julia Weiss, Raúl Zornoza, María Martínez-Mena, Eloisa García, Margarita Ros
The high use of pesticides, herbicides, and unsustainable farming practices resulted in losses of soil quality. Sustainable farming practices such as intercropping could be a good alternative to traditional monocrop, especially using legumes such as cowpea ( Vigna unguiculata L. Walp ). In this study, different melon and cowpea intercropping patterns (melon mixed with cowpea in the same row (MC1); alternating one melon row and one cowpea row (MC2); alternating two melon rows and one cowpea row (MC3)) were assayed to study the intercropping effect on soil bacterial community through 16S rRNA region in a 3-year experiment...
2022: Frontiers in Microbiology
#29
JOURNAL ARTICLE
[Recommendations For The Management Of Spontaneous Intracerebral Hemorrhage During Hospitalization].
Santiago G Pigretti, Matías Mirofsky, Darío E García, Cristian Issac, Pascual Valdez, Gabriel G Persi, Carlos E Mamani, Jorgelina Guyon, Héctor Álvarez, Mariana Montes, José M Daza Aramayo, Pablo Iturrieta, Hernán Chaves, Verónica Sarmiento, Leandro Tumino, Gustavo Domeniconi, Rosa Castagna, Rodrigo Sabio, Walter Videtta, Nicolás Ciarrocchi, Damián Lerman, Daiana E Dossi, Natalia R Balian, Gonzalo Rufino Saravia, Matías J Alet, Federico Rodríguez Lucci, Celina Ciardi, Virginia Pujol Lereis, Santiago Claverie, Matías Casanova, Leonardo González, Juan Manuel Mónaco, Rolando E Cárdenas, Juan José Cirio, Jessica Arturi, Flavio Requejo, Pedro L Plou, Gabriela Orzuza, Pablo Bonardo, María Fernanda Díaz, Silvio Payaslian, María Gabriela Andrade, Maia M Gomez Schneider, Marina Romano, Pedro Colla Machado, José Arroyo, María Florencia Arcondo, Silvana Svampa, Cristian Armenteros, Virginia Tejada Jacob, María Cristina Zurrú
Stroke is the leading cause of neurological disability in people over 40 years of age and the fourth leading cause of death in Argentina. In the last ten years, the indexed publications related to the treatment of ischemic stroke were more numerous than those of hemorrhagic stroke. The objective of this material is to provide local and updated recommendations for the management of patients with spontaneous intracerebral hemorrhage during hospitalization. For the writing of this manuscript, diferent specialists were convened to form working groups...
2022: Medicina
#30
MULTICENTER STUDY
Asya Agulnik, Alejandra Gonzalez Ruiz, Hilmarie Muniz-Talavera, Angela K Carrillo, Adolfo Cárdenas, Maria F Puerto-Torres, Marcela Garza, Tania Conde, Dora J Soberanis Vasquez, Alejandra Méndez Aceituno, Carlos Acuña Aguirre, Yvania Alfonso, Shillel Yahamy Álvarez Arellano, Deiby Argüello Vargas, Rosario Batista, Erika Esther Blasco Arriaga, Mayra Chávez Rios, María Elena Cuencio Rodríguez, Ever Amilcar Fing Soto, Wendy Gómez-García, Rafael H Guillén Villatoro, María de Lourdes Gutiérrez Rivera, Martha Herrera Almanza, Yajaira V Jimenez Antolinez, Maria Susana Juárez Tobias, Norma Araceli López Facundo, Ruth Angélica Martínez Soria, Kenia Miller, Scheybi Miralda, Roxana Morales, Natalia Negroe Ocampo, Alejandra Osuna, Claudia Pascual Morales, Clara Krystal Pérez Fermin, Carlos M Pérez Alvarado, Estuardo Pineda, Carlos Andrés Portilla, Ligia Estefanía Rios López, Jocelyn Rivera, Arely Saraí Sagaón Olivares, Mélida Cristina Saguay Tacuri, Beatriz T Salas Mendoza, Ivel Solano Picado, Verónica Soto Chávez, Isidoro Tejocote Romero, Daniel Tatay, Juliana Teixeira Costa, Erika Villanueva, Marielba Villegas Pacheco, Virginia R McKay, Monika L Metzger, Paola Friedrich, Carlos Rodriguez-Galindo
BACKGROUND: Pediatric early warning systems (PEWS) aid in the early identification of deterioration in hospitalized children with cancer; however, they are under-used in resource-limited settings. The authors use the knowledge-to-action framework to describe the implementation strategy for Proyecto Escala de Valoracion de Alerta Temprana (EVAT), a multicenter quality-improvement collaborative, to scale-up PEWS in pediatric oncology centers in Latin America. METHODS: Proyecto EVAT mentored participating centers through an adaptable implementation strategy to: (1) monitor clinical deterioration in children with cancer, (2) contextually adapt PEWS, (3) assess barriers to using PEWS, (4) pilot and implement PEWS, (5) monitor the use of PEWS, (6) evaluate outcomes, and (7) sustain PEWS...
November 15, 2022: Cancer
#31
JOURNAL ARTICLE
A Differential Profile of Biomarkers between Patients with Atrial Fibrillation and Healthy Controls.
Ana Merino-Merino, Ruth Saez-Maleta, Ricardo Salgado-Aranda, Daniel AlKassam-Martinez, Virginia Pascual-Tejerina, Javier Martin-Gonzalez, Javier Garcia-Fernandez, Jose-Angel Perez-Rivera
Atrial fibrillation (AF) is explained by anatomical and electrophysiological changes in the atria determined by high pressure, dilatation, infiltration and inflammation in the myocardium. There are some biomarkers implicated in these processes, namely, NT-proBNP, high sensitivity troponin (Hs-Tn), urate, galectin-3, ST2, C reactive protein and fibrinogen. The aim of this study was to assess differences in these biomarkers between patients with AF and healthy controls. We designed a cross-sectional study consecutively including all patients undergoing electrical cardioversion in our hospital for persistent AF and matched healthy controls...
August 30, 2022: Journal of Personalized Medicine
#32
JOURNAL ARTICLE
Yevgeniya Svyryd, Virginia Pascual-Ramos, Irazú Contreras-Yañez, Luís A Muñoz-Tellez, Leonora Luna-Muñoz, María A López-Hernández, Adolfo Aguayo-Gómez, Osvaldo M Mutchinick
Background: Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic synovial joint inflammation, progressive disability, premature immune aging, and telomere length (TL) shortening. Objectives: The objective of the study was to study TL changes in patients at early disease onset and after follow-up. Methods: Relative leukocyte TL (rLTL) was measured by quantitative polymerase chain reaction (qPCR) in 88 at-admission patients (AAP) with < 1 year of symptoms onset, self-compared after follow-up, and a reference group of sex- and age-matched healthy individuals...
2022: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
#33
JOURNAL ARTICLE
Virginia Meca-Lallana, José M García Domínguez, Rocío López Ruiz, Jesús Martín-Martínez, Adrián Arés Luque, Miguel A Hernández Pérez, José M Prieto González, Lamberto Landete Pascual, Jaume Sastre-Garriga
Cladribine is a disease-modifying selective immune reconstitution oral therapy for adult patients with highly active relapsing multiple sclerosis (RMS). It was approved in the USA in 2019 and in Europe in 2017, thus there are still gaps in existing guidelines for using cladribine tablets in clinical practice. Nine experts with extensive experience in managing patients with multiple sclerosis in Spain identified some of the unanswered questions related to the real-life use of cladribine tablets. They reviewed the available clinical trial data and real-world evidence, including their own experiences of using cladribine, over the course of three virtual meetings held between November 2020 and January 2021...
December 2022: Neurology and Therapy
#34
JOURNAL ARTICLE
Virginia Pascual-Tejerina, Pedro Beneyto, Tomás Cantón, Luis Manuel Hernando, Luis F Pajín, José Moreu-Burgos, Luis F López-Almodóvar, Luis Rodríguez-Padial
INTRODUCTION: Untreated, severe, symptomatic aortic stenosis is associated with an ominous diagnosis without intervention. This study aims to determine the impact of the COVID-19 pandemic on the mortality of patients with severe stenosis during the first wave and compare it with the same period last year. METHODS: All patients who went to the hospitals in a spanish region during the first wave, and in the same period of previous year, were analysed using Artificial Intelligence-based software, evaluating the mortality of patients with severe aortic stenosis with and without COVID-19 during the pandemic and the pre-COVID era...
December 2022: Cirugia española
#35
JOURNAL ARTICLE
Guillermo A Guaracha-Basáñez, Irazú Contreras-Yáñez, Vivian A Estrada González, Lexli D Pacheco-Santiago, Salvador S Valverde-Hernández, Virginia Pascual-Ramos
OBJECTIVE: Patients and physicians can naturally adopt hybrid healthcare models that combine face-to-face consultations with telemedicine. The study's objective was to compare the impact of two healthcare interventions, hybrid care modality and face-to-face consultation, on the patient-reported outcomes of rheumatoid arthritis patients, during the COVID-19 pandemic. METHODS: Consecutive outpatients reincorporated to a clinic previously in lockdown were invited to a non-inferiority, randomized study (October 2020--May 2022)...
August 31, 2022: Journal of Telemedicine and Telecare
#36
JOURNAL ARTICLE
Ariadna Munté-Pascual, Gisela Redondo-Sama, Irene De Vicente, Virginia Matulic
The scientific literature has already shown that health information is a factor that contributes to reduce health disparities, improving the situation of vulnerable groups, such as homeless people. However, less is known about the ways that health information has been spread by social workers and related professionals to homeless people in the first moments of the COVID-19 pandemic. This work analyses some social work actions related to health information addressed to homeless people and to identify its impact during the lockdown in Barcelona...
August 15, 2022: International Journal of Environmental Research and Public Health
#37
JOURNAL ARTICLE
Irazú Contreras-Yáñez, Guillermo Arturo Guaracha-Basáñez, Maximiliano Cuevas-Montoya, José de Jesús Hernández-Bautista, Virginia Pascual-Ramos
BACKGROUND: Medication adherence is suboptimal in rheumatoid arthritis (RA) patients and impacts outcomes. DMARD-free remission (DFR) is a sustainable and achievable outcome in a minority of RA patients. Different factors have been associated with DFR, although persistence in therapy (PT), a component of the adherence construct, has never been examined. The study's primary aim was to investigate the impact of PT's characteristics on DFR in a cohort of Hispanic patients with recent-onset RA...
August 12, 2022: Arthritis Research & Therapy
#38
RANDOMIZED CONTROLLED TRIAL
Andra-Rodica Balanescu, Gustavo Citera, Virginia Pascual-Ramos, Deepak L Bhatt, Carol A Connell, David Gold, All-Shine Chen, Gosford Sawyerr, Andrea B Shapiro, Janet E Pope, Hendrik Schulze-Koops
OBJECTIVES: To characterise infections in patients with rheumatoid arthritis (RA) in ORAL Surveillance. METHODS: In this open-label, randomised controlled trial, patients with RA aged≥50 years with ≥1 additional cardiovascular risk factor received tofacitinib 5 or 10 mg two times per day or a tumour necrosis factor inhibitor (TNFi). Incidence rates (IRs; patients with first events/100 patient-years) and hazard ratios (HRs) were calculated for infections, overall and by age (50-<65 years; ≥65 years)...
November 2022: Annals of the Rheumatic Diseases
#39
JOURNAL ARTICLE
Alfonso Gastelum-Strozzi, Virginia Pascual, Adolfo Hernández-Garduño, José Francisco Moctezuma-Rios, Guillermo Arturo Guaracha-Basañez, Thalya Sotelo, Conrado Garcia-Garcia, Irazú Contreras-Yañez, Everardo Álvarez-Hernández, Claudia Infante-Castañeda, Ingris Peláez-Ballestas
OBJECTIVES: Risk perception of the COVID-19 pandemic may affect chronic disease outcomes among patients with rheumatic diseases (RD). To describe and compare the perception of risk and effects of the COVID-19 pandemic on patients with RD from two health care centers compared with a control group. METHODS: A retrospective case-control study was conducted. Patient respondents completed an online survey to measure risk perception and effects of the COVID-19 pandemic...
October 2022: Clinical Rheumatology
#40
JOURNAL ARTICLE
Raquel Cruz, Silvia Diz-de Almeida, Miguel López de Heredia, Inés Quintela, Francisco C Ceballos, Guillermo Pita, José M Lorenzo-Salazar, Rafaela González-Montelongo, Manuela Gago-Domínguez, Marta Sevilla Porras, Jair Antonio Tenorio Castaño, Julian Nevado, Jose María Aguado, Carlos Aguilar, Sergio Aguilera-Albesa, Virginia Almadana, Berta Almoguera, Nuria Alvarez, Álvaro Andreu-Bernabeu, Eunate Arana-Arri, Celso Arango, María J Arranz, Maria-Jesus Artiga, Raúl C Baptista-Rosas, María Barreda-Sánchez, Moncef Belhassen-Garcia, Joao F Bezerra, Marcos A C Bezerra, Lucía Boix-Palop, María Brion, Ramón Brugada, Matilde Bustos, Enrique J Calderón, Cristina Carbonell, Luis Castano, Jose E Castelao, Rosa Conde-Vicente, M Lourdes Cordero-Lorenzana, Jose L Cortes-Sanchez, Marta Corton, M Teresa Darnaude, Alba De Martino-Rodríguez, Victor Del Campo-Pérez, Aranzazu Diaz de Bustamante, Elena Domínguez-Garrido, Andre D Luchessi, Rocío Eiros, Gladys Mercedes Estigarribia Sanabria, María Carmen Fariñas, Uxía Fernández-Robelo, Amanda Fernández-Rodríguez, Tania Fernández-Villa, Belén Gil-Fournier, Javier Gómez-Arrue, Beatriz González Álvarez, Fernan Gonzalez Bernaldo de Quirós, Javier González-Peñas, Juan F Gutiérrez-Bautista, María José Herrero, Antonio Herrero-Gonzalez, María A Jimenez-Sousa, María Claudia Lattig, Anabel Liger Borja, Rosario Lopez-Rodriguez, Esther Mancebo, Caridad Martín-López, Vicente Martín, Oscar Martinez-Nieto, Iciar Martinez-Lopez, Michel F Martinez-Resendez, Angel Martinez-Perez, Juliana F Mazzeu, Eleuterio Merayo Macías, Pablo Minguez, Victor Moreno Cuerda, Vivian N Silbiger, Silviene F Oliveira, Eva Ortega-Paino, Mara Parellada, Estela Paz-Artal, Ney P C Santos, Patricia Pérez-Matute, Patricia Perez, M Elena Pérez-Tomás, Teresa Perucho, Mel Lina Pinsach-Abuin, Ericka N Pompa-Mera, Gloria L Porras-Hurtado, Aurora Pujol, Soraya Ramiro León, Salvador Resino, Marianne R Fernandes, Emilio Rodríguez-Ruiz, Fernando Rodriguez-Artalejo, José A Rodriguez-Garcia, Francisco Ruiz Cabello, Javier Ruiz-Hornillos, Pablo Ryan, José Manuel Soria, Juan Carlos Souto, Eduardo Tamayo, Alvaro Tamayo-Velasco, Juan Carlos Taracido-Fernandez, Alejandro Teper, Lilian Torres-Tobar, Miguel Urioste, Juan Valencia-Ramos, Zuleima Yáñez, Ruth Zarate, Tomoko Nakanishi, Sara Pigazzini, Frauke Degenhardt, Guillaume Butler-Laporte, Douglas Maya-Miles, Luis Bujanda, Youssef Bouysran, Adriana Palom, David Ellinghaus, Manuel Martínez-Bueno, Selina Rolker, Sara Amitrano, Luisa Roade, Francesca Fava, Christoph D Spinner, Daniele Prati, David Bernardo, Federico Garcia, Gilles Darcis, Israel Fernández-Cadenas, Jan Cato Holter, Jesus M Banales, Robert Frithiof, Stefano Duga, Rosanna Asselta, Alexandre C Pereira, Manuel Romero-Gómez, Beatriz Nafría-Jiménez, Johannes R Hov, Isabelle Migeotte, Alessandra Renieri, Anna M Planas, Kerstin U Ludwig, Maria Buti, Souad Rahmouni, Marta E Alarcón-Riquelme, Eva C Schulte, Andre Franke, Tom H Karlsen, Luca Valenti, Hugo Zeberg, Brent Richards, Andrea Ganna, Mercè Boada, Itziar de Rojas, Agustín Ruiz, Pascual Sánchez-Juan, Luis Miguel Real, Encarna Guillen-Navarro, Carmen Ayuso, Anna González-Neira, José A Riancho, Augusto Rojas-Martinez, Carlos Flores, Pablo Lapunzina, Angel Carracedo
Here, we describe the results of a genome-wide study conducted in 11 939 coronavirus disease 2019 (COVID-19) positive cases with an extensive clinical information that were recruited from 34 hospitals across Spain (SCOURGE consortium). In sex-disaggregated genome-wide association studies for COVID-19 hospitalization, genome-wide significance (P < 5 × 10-8) was crossed for variants in 3p21.31 and 21q22.11 loci only among males (P = 1.3 × 10-22 and P = 8...
November 10, 2022: Human Molecular Genetics
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