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Julia I Ellyard, Rebekka Jerjen, Jaime L Martin, Adrian Lee, Matthew A Field, Simon H Jiang, Jean Cappello, Svenja K Naumann, T Daniel Andrews, Hamish S Scott, Marco G Casarotto, Christopher C Goodnow, Jeffrey Chaitow, Virginia Pascual, Paul Hertzog, Stephen I Alexander, Matthew C Cook, Carola G Vinuesa
No abstract text is available yet for this article.
February 2016: Pathology
Simon Blankley, Christine M Graham, Jacob Turner, Matthew P R Berry, Chloe I Bloom, Zhaohui Xu, Virginia Pascual, Jacques Banchereau, Damien Chaussabel, Ronan Breen, George Santis, Derek M Blankenship, Marc Lipman, Anne O'Garra
BACKGROUND: Mycobacterium tuberculosis infection is a leading cause of infectious death worldwide. Gene-expression microarray studies profiling the blood transcriptional response of tuberculosis (TB) patients have been undertaken in order to better understand the host immune response as well as to identify potential biomarkers of disease. To date most of these studies have focused on pulmonary TB patients with gene-expression profiles of extra-pulmonary TB patients yet to be compared to those of patients with pulmonary TB or sarcoidosis...
2016: PloS One
Tae Whan Kim, Seunghee Hong, Yin Lin, Elise Murat, HyeMee Joo, Taeil Kim, Virginia Pascual, Yong-Jun Liu
Type I IFNs are crucial mediators of human innate and adaptive immunity and are massively produced from plasmacytoid dendritic cells (pDCs). IFN regulatory factor (IRF)7 is a critical regulator of type I IFN production when pathogens are detected by TLR 7/9 in pDC. However, hyperactivation of pDC can cause life-threatening autoimmune diseases. To avoid the deleterious effects of aberrant pDC activation, tight regulation of IRF7 is required. Nonetheless, the detailed mechanisms of how IRF7 transcription is regulated in pDC are still elusive...
September 14, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
Ana K Romero-Guzmán, Víctor M Menchaca-Tapia, Irazú Contreras-Yáñez, Virginia Pascual-Ramos
BACKGROUND: In 2004, we initiated an inception cohort of patients with recent-onset rheumatoid arthritis (RA). Hand function was incorporated into evaluations from 2014 onward. The objectives were to examine hand function in our cohort, compare hand function with function in healthy controls and determine the factors associated with impaired function. METHODS: From February 2014 to June 2015, 139 patients (97.2 % of the cohort) had disease activity scored (28 joints, [DAS28]); the Michigan Hand Outcome Questionnaire (MHQ) and Disabilities of the Arm, Shoulder and Hand Outcome Measure (DASH) were completed, and the tip-, key- and palmar-pinch and grip strengths were measured...
2016: BMC Musculoskeletal Disorders
Juan Manuel Castro, Virginia Angélica Bianchi, Mariano Pascual, Andrés Venturino, Carlos Marcelo Luquet
The aim of this work was to characterize the immune response (total hemocyte number, cell type proportion, hemocyte viability, lysosomal membrane stability, phagocytic activity, cellular acid and alkaline phosphatase activity, and humoral bacteriolytic and phenoloxidase activity) in Diplodon chilensis exposed to 0.2 mg/L of azinphos-methyl (AZM), using Escherichia coli as immunological and prooxidant challenge. Additionally, glutathione-S-transferase (GST) and lipid peroxidation (TBARS) were analyzed in gill tissue...
September 7, 2016: Environmental Toxicology and Chemistry
Yemil Atisha-Fregoso, Guadalupe Lima, Virginia Pascual-Ramos, Miguel Baños-Peláez, Hilda Fragoso-Loyo, Juan Jakez-Ocampo, Irazú Contreras-Yáñez, Luis Llorente
OBJECTIVE: To compare drug efflux function of ABCB1 and ABCG2 transporters in rheumatoid arthritis (RA) patients with active disease and in remission. METHODS: Twenty two active RA patients (DAS28 ≥3.2) and 22 patients in remission (DAS28<2.6) were selected from an early RA clinic. All patients were evaluated at study inclusion and six months later. ABCB1 and ABCG2 functional activity was measured in peripheral lymphocytes by flow cytometry. The percentage of cells able to extrude substrates for ABCB1 and ABCG2 was recorded...
2016: PloS One
Victor M Menchaca-Tapia, Elizabeth M Rodríguez, Irazú Contreras-Yáñez, Martin Iglesias-Morales, Virginia Pascual-Ramos
BACKGROUND: Up to 70% of patients with long-standing rheumatoid arthritis (RA) may present with rheumatic hand disease and benefit from hand surgical procedures (HSPs). OBJECTIVE: Through retrospective review, the present study aimed to report HSPs in RA patients at a tertiary care centre to identify patient adverse outcomes (AOs) and their predictors. METHODS: From 1989 to 2013, 96 patients who underwent ≥1 HSP(s) were identified from two local registries; their clinical records were independently reviewed by two trained physicians (surgeon and clinical) who used a standardized format...
2016: Plastic Surgery
Ma Blanca Pascual, Virginia Echevarria, Ma José Gonzalo, Lourdes Hernández-Apaolaza
It is well established the beneficial role of silicon (Si) in alleviating abiotic stress. However, it remains poorly understood the mechanisms of the Si-mediated protection against metal deficiency, especially the zinc (Zn) one. Recently, it has been proposed that Si may act by an interaction with this biometal in the root apoplast contributing to its movement through the plant, as in the case of Fe deficiency. In the present work, the effect of initial or continuous Si doses in soybean Zn deficient plants has been studied...
July 11, 2016: Plant Physiology and Biochemistry: PPB
Virginia L Gaveglio, Ana C Pascual, Norma M Giusto, Susana J Pasquaré
The aim of this work was to study how age-related changes could modify several enzymatic activities that regulate lipid mediator levels in nuclei from rat cerebellum and how these changes are modulated by all-trans retinoic acid (RA), docosahexaenoic acid (DHA) and arachidonic acid (AA). The higher phosphatidate phosphohydrolase activity and lower diacylglycerol lipase (DAGL) activity observed in aged animals compared with adults could augment diacylglycerol (DAG) availability in the former. Additionally, monoacylglycerol (MAG) availability could be high due to an increase in lysophosphatidate phosphohydrolase (LPAPase) activity and a decrease in monocylglycerol lipase activity...
August 15, 2016: Archives of Biochemistry and Biophysics
Romain Banchereau, Seunghee Hong, Brandi Cantarel, Nicole Baldwin, Jeanine Baisch, Michelle Edens, Alma-Martina Cepika, Peter Acs, Jacob Turner, Esperanza Anguiano, Parvathi Vinod, Shaheen Khan, Gerlinde Obermoser, Derek Blankenship, Edward Wakeland, Lorien Nassi, Alisa Gotte, Marilynn Punaro, Yong-Jun Liu, Jacques Banchereau, Jose Rossello-Urgell, Tracey Wright, Virginia Pascual
No abstract text is available yet for this article.
June 2, 2016: Cell
José Antonio Allué, Leticia Sarasa, María Izco, Virginia Pérez-Grijalba, Noelia Fandos, María Pascual-Lucas, Samuel Ogueta, Pedro Pesini, Manuel Sarasa
APPswe/PS1dE9 and Tg2576 are very common transgenic mouse models of Alzheimer's disease (AD), used in many laboratories as tools to research the mechanistic process leading to the disease. In order to augment our knowledge about the amyloid-β (Aβ) isoforms present in both transgenic mouse models, we have developed two chromatographic methods, one acidic and the other basic, for the characterization of the Aβ species produced in the brains of the two transgenic mouse models. After immunoprecipitation and micro-liquid chromatography-electrospray ionization mass spectrometry/mass spectrometry, 10 species of Aβ, surprisingly all of human origin, were detected in the brain of Tg2576 mouse, whereas 39 species, of both murine and human origin, were detected in the brain of the APP/PS1 mouse...
May 30, 2016: Journal of Alzheimer's Disease: JAD
Gene V Wallenstein, Keith S Kanik, Bethanie Wilkinson, Stanley Cohen, Maurizio Cutolo, Roy Fleishmann, Mark C Genovese, Juan Gomez Reino, David Gruben, Joel Kremer, Sriram Krishnaswami, Eun Bong Lee, Virginia Pascual-Ramos, Vibeke Strand, Samuel H Zwillich
OBJECTIVES: Tofacitinib is an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis (RA). Here we investigated the effects of tofacitinib on patient-reported outcomes (PRO) in patients with active RA. METHODS: Two, 6-month, double-blind, placebo-controlled Phase 2b studies were performed. The combination study evaluated patients with inadequate response to methotrexate who received tofacitinib 1-15 mg twice daily (BID), 20 mg once daily or placebo, on background methotrexate...
May 2016: Clinical and Experimental Rheumatology
Sabina Herrera, Luisa Sorlí, Maria Jose Pérez-Sáez, Patricia Ruiz-Garbajosa, Clara Barrios, Virginia Plasencia, Milagro Montero, Roser Terradas, Marta Crespo, Xavier Castells, Rafael Cantón, Julio Pascual, Juan Pablo Horcajada
OBJECTIVE: To describe a clonal outbreak due to vancomycin-resistant Enterococcus faecium (VREF) in the nephrology and renal transplant unit of a tertiary teaching hospital in Barcelona, Spain, and to highlight how active patient and environment surveillance cultures, as well as prompt and directed intervention strategies, mainly environmental, helped to successfully bring it under control. PATIENTS AND METHODS: A study was conducted on patients admitted to the nephrology ward with any culture positive for VREF over a 6-month period (August 2012-January 2013)...
May 4, 2016: Enfermedades Infecciosas y Microbiología Clínica
Simone Caielli, Shruti Athale, Bojana Domic, Elise Murat, Manjari Chandra, Romain Banchereau, Jeanine Baisch, Kate Phelps, Sandra Clayton, Mei Gong, Tracey Wright, Marilynn Punaro, Karolina Palucka, Cristiana Guiducci, Jacques Banchereau, Virginia Pascual
Autoantibodies against nucleic acids and excessive type I interferon (IFN) are hallmarks of human systemic lupus erythematosus (SLE). We previously reported that SLE neutrophils exposed to TLR7 agonist autoantibodies release interferogenic DNA, which we now demonstrate to be of mitochondrial origin. We further show that healthy human neutrophils do not complete mitophagy upon induction of mitochondrial damage. Rather, they extrude mitochondrial components, including DNA (mtDNA), devoid of oxidized (Ox) residues...
May 2, 2016: Journal of Experimental Medicine
Romain Banchereau, Seunghee Hong, Brandi Cantarel, Nicole Baldwin, Jeanine Baisch, Michelle Edens, Alma-Martina Cepika, Peter Acs, Jacob Turner, Esperanza Anguiano, Parvathi Vinod, Shaheen Kahn, Gerlinde Obermoser, Derek Blankenship, Edward Wakeland, Lorien Nassi, Alisa Gotte, Marilynn Punaro, Yong-Jun Liu, Jacques Banchereau, Jose Rossello-Urgell, Tracey Wright, Virginia Pascual
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by loss of tolerance to nucleic acids and highly diverse clinical manifestations. To assess its molecular heterogeneity, we longitudinally profiled the blood transcriptome of 158 pediatric patients. Using mixed models accounting for repeated measurements, demographics, treatment, disease activity (DA), and nephritis class, we confirmed a prevalent IFN signature and identified a plasmablast signature as the most robust biomarker of DA...
April 21, 2016: Cell
Gretel Galicia-Hernández, Federico Parra-Salcedo, Paulina Ugarte-Martínez, Irazú Contreras-Yáñez, Alfredo Ponce-de-León, Virginia Pascual-Ramos
OBJECTIVES: Rheumatoid arthritis (RA) guidelines have moved toward intensive treatment aimed at remission. Treatment and disease activity are predictors of infections; patients from developing countries have additional predictors that may further impact the infection spectrum. Our aim was to describe serious infection events (SIEs), predictors and impact on RA outcomes, in a cohort of Mexican Mestizo patients. METHODS: Up to February 2015, charts from 176 early RA patients were reviewed by a single data abstracter...
March 2016: Clinical and Experimental Rheumatology
Jonathan M Pitt, Simon Blankley, Krzysztof Potempa, Christine M Graham, Lucia Moreira-Teixeira, Finlay W McNab, Ashleigh Howes, Evangelos Stavropoulos, Virginia Pascual, Jacques Banchereau, Damien Chaussabel, Anne O'Garra
Analysis of the mouse transcriptional response to Listeria monocytogenes infection reveals that a large set of genes are perturbed in both blood and tissue and that these transcriptional responses are enriched for pathways of the immune response. Further we identified enrichment for both type I and type II interferon (IFN) signaling molecules in the blood and tissues upon infection. Since type I IFN signaling has been reported widely to impair bacterial clearance we examined gene expression from blood and tissues of wild type (WT) and type I IFNαβ receptor-deficient (Ifnar1-/-) mice at the basal level and upon infection with L...
2016: PloS One
Virginia A Bianchi, Juan M Castro, Iara Rocchetta, Visitación Conforti, Mariano Pascual, Carlos M Luquet
In order to test if orally supplied Euglena sp. cells modulate the physiological status of bivalves during bioremediation procedures, we evaluated the effect of Euglena gracilis diet on the immune response, oxidative balance and metabolic condition of Diplodon chilensis exposed to sewage water pollution. Mussels were fed for 90 days with E. gracilis (EG) or Scenedesmus vacuolatus (SV, control diet), and then exposed for 10 days at three sites along the Pocahullo river basin: 1) an unpolluted site, upstream of the city (control, C); 2) upstream (UpS) and 3) downstream (DoS) from the main tertiary-treated sewage discharge, in the city of San Martín de los Andes, Northwest Patagonia, Argentina...
April 2016: Fish & Shellfish Immunology
Greg Finak, Marc Langweiler, Maria Jaimes, Mehrnoush Malek, Jafar Taghiyar, Yael Korin, Khadir Raddassi, Lesley Devine, Gerlinde Obermoser, Marcin L Pekalski, Nikolas Pontikos, Alain Diaz, Susanne Heck, Federica Villanova, Nadia Terrazzini, Florian Kern, Yu Qian, Rick Stanton, Kui Wang, Aaron Brandes, John Ramey, Nima Aghaeepour, Tim Mosmann, Richard H Scheuermann, Elaine Reed, Karolina Palucka, Virginia Pascual, Bonnie B Blomberg, Frank Nestle, Robert B Nussenblatt, Ryan Remy Brinkman, Raphael Gottardo, Holden Maecker, J Philip McCoy
Standardization of immunophenotyping requires careful attention to reagents, sample handling, instrument setup, and data analysis, and is essential for successful cross-study and cross-center comparison of data. Experts developed five standardized, eight-color panels for identification of major immune cell subsets in peripheral blood. These were produced as pre-configured, lyophilized, reagents in 96-well plates. We present the results of a coordinated analysis of samples across nine laboratories using these panels with standardized operating procedures (SOPs)...
2016: Scientific Reports
Luis A González-Naranjo, Octavio Martínez Betancur, Graciela S Alarcón, Manuel F Ugarte-Gil, Daniel Jaramillo-Arroyave, Daniel Wojdyla, Guillermo J Pons-Estel, Federico Rondón-Herrera, Gloria M Vásquez-Duque, Gerardo Quintana-López, Nilzio A Da Silva, João C Tavares Brenol, Gil Reyes-Llerena, Virginia Pascual-Ramos, Mary C Amigo, Loreto Massardo, José Alfaro-Lozano, María I Segami, María H Esteva-Spinetti, Antonio Iglesias-Gamarra, Bernardo A Pons-Estel
OBJECTIVE: To examine hematological manifestations' correlates and their impact on damage accrual and mortality in SLE patients from the multiethnic, Latin American, GLADEL cohort. METHODS: In patients with recent SLE diagnosis (≤2 years), the association between follow-up hematological manifestations (per ACR criteria) and socio-demographic and clinical variables was examined by univariable and multivariable logistic regressions; their impact on damage accrual and mortality was examined by Poisson and Cox proportional-hazards regression analyses, respectively...
June 2016: Seminars in Arthritis and Rheumatism
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