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JOURNAL ARTICLE
Jonathan Z Pan, Zhanqiang Wang, Wei Sun, Peipei Pan, Wei Li, Yongtao Sun, Shoulin Chen, Amity Lin, Wulin Tan, Liangliang He, Jacob Greene, Virginia Yao, Lijun An, Rich Liang, Qifeng Li, Jessica Yu, Lingyi Zhang, Nikolaos Kyritsis, Xuan Duong Fernandez, Sara Moncivais, Esmeralda Mendoza, Pamela Fung, Gongming Wang, Xinhuan Niu, Qihang Du, Zhaoyang Xiao, Yuwen Chang, Peiyuan Lv, J Russell Huie, Abel Torres-Espin, Adam R Ferguson, Debra D Hemmerle, Jason F Talbott, Philip R Weinstein, Lisa U Pascual, Vineeta Singh, Anthony M DiGiorgio, Rajiv Saigal, William D Whetstone, Geoffrey T Manley, Sanjay S Dhall, Jacqueline C Bresnahan, Mervyn Maze, Xiangning Jiang, Neel S Singhal, Michael S Beattie, Hua Su, Zhonghui Guan
BACKGROUND: Although many molecules have been investigated as biomarkers for spinal cord injury (SCI) or ischemic stroke, none of them are specifically induced in central nervous system (CNS) neurons following injuries with low baseline expression. However, neuronal injury constitutes a major pathology associated with SCI or stroke and strongly correlates with neurological outcomes. Biomarkers characterized by low baseline expression and specific induction in neurons post-injury are likely to better correlate with injury severity and recovery, demonstrating higher sensitivity and specificity for CNS injuries compared to non-neuronal markers or pan-neuronal markers with constitutive expressions...
April 2024: Clinical and Translational Medicine
#2
JOURNAL ARTICLE
Virginia Pascual-Ramos, Irazú Contreras-Yáñez, Maximiliano Cuevas-Montoya, Guillermo Arturo Guaracha-Basañez, Mario García-Alanis, Oscar Rodríguez-Mayoral, Harvey Max Chochinov
BACKGROUND: The loss of perceived dignity is an existential source of human suffering, described in patients with cancer and chronic diseases and hospitalized patients but rarely explored among patients with rheumatic diseases (RMDs). We recently observed that distress related to perceived dignity (DPD) was present in 26.9% of Mexican patients with different RMDs. The study aimed to investigate the factors associated with DPD. METHODS: This cross-sectional study was performed between February and September 2022...
April 10, 2024: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
#3
JOURNAL ARTICLE
Raúl Velamazán, Pablo López-Guillén, Samuel J Martínez-Domínguez, Daniel Abad Baroja, Daniel Oyón, Anna Arnau, Lara M Ruiz-Belmonte, Javier Tejedor-Tejada, Raul Zapater, Noelia Martín-Vicente, Pedro José Fernández-Esparcia, Ana Belén Julián Gomara, Violeta Sastre Lozano, Juan José Manzanares García, Irene Chivato Martín-Falquina, Laura Andrés Pascual, Nuria Torres Monclus, Natividad Zaragoza Velasco, Eukene Rojo, Berta Lapeña-Muñoz, Virginia Flores, Arantxa Díaz Gómez, Pablo Cañamares-Orbís, Isabel Vinzo Abizanda, Natalia Marcos Carrasco, Laura Pardo Grau, Guillermo García-Rayado, Judith Millastre Bocos, Ana Garcia Garcia de Paredes, María Vaamonde Lorenzo, Arantzazu Izagirre Arostegi, Edgard Efrén Lozada-Hernández, José Antonio Velarde-Ruiz Velasco, Enrique de-Madaria
BACKGROUND: Delayed cholecystectomy in patients with symptomatic gallstone disease is associated with recurrence. Limited data on the recurrence patterns and the factors that determine them are available. OBJECTIVE: We aimed to determine the pattern of relapse in each symptomatic gallstone disease (acute pancreatitis, cholecystitis, cholangitis, symptomatic choledocholithiasis, and biliary colic) and determine the associated factors. METHODS: RELAPSTONE was an international multicenter retrospective cohort study...
February 20, 2024: United European Gastroenterology Journal
#4
JOURNAL ARTICLE
Elizabeth E Sloan, Katarina Kmetova, Somanathapura K NaveenKumar, Lyndsay Kluge, Emily Chong, Claire K Hoy, Srilakshmi Yalavarthi, Cyrus Sarosh, Jeanine Baisch, Lynnette Walters, Lorien Nassi, Julie Fuller, Jessica L Turnier, Virginia Pascual, Tracey B Wright, Jacqueline A Madison, Jason S Knight, Ayesha Zia, Yu Zuo
Our study aimed to evaluate the presence, clinical associations, and potential mechanistic roles of non-criteria antiphospholipid antibodies (aPL) and circulating calprotectin, a highly stable marker of neutrophil extracellular trap release (NETosis), in pediatric APS patients. We found that 79% of pediatric APS patients had at least one non-criteria aPL at moderate-to-high titer. Univariate logistic regression demonstrated that positive anti-beta-2 glycoprotein I domain 1 (anti-D1) IgG (p = 0...
February 12, 2024: Clinical Immunology: the Official Journal of the Clinical Immunology Society
#5
JOURNAL ARTICLE
Romina Nieto, Rosana Quintana, Ernesto Zavala-Flores, Rosa Serrano, Karen Roberts, Luis J Catoggio, Mercedes A García, Guillermo A Berbotto, Verónica Saurit, Eloisa Bonfa, Eduardo F Borba, Lilian T Lavras Costallat, Nilzio A Da Silva, Emilia I Sato, Joao C Tavares Brenol, Loreto Massardo, Oscar J Neira, Gloria Vázquez, Marlene Guibert Toledano, Virginia Pascual-Ramos, María J Sauza Del Pozo, Leonor A Barile-Fabris, Mary-Carmen Amigo, Ignacio García De La Torre, Eduardo M Acevedo-Vásquez, María I Segami, Rosa Chacón-Díaz, María H Esteva-Spinetti, Graciela S Alarcón, Bernardo A Pons-Estel, Guillermo J Pons-Estel
BACKGROUND: Systemic lupus erythematosus (SLE) often mimics symptoms of other diseases, and the interval between symptom onset and diagnosis may be long in some of these patients. Aims: To describe the characteristics associated with the time to SLE diagnosis and its impact on damage accrual and mortality in patients with SLE from a Latin American inception cohort. METHODS: Patients were from a multi-ethnic, multi-national Latin-American SLE inception cohort. All participating centers had specialized lupus clinics...
February 9, 2024: Lupus
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JOURNAL ARTICLE
Sathyabaarathi Ravichandran, Fernando Erra-Diaz, Onur E Karakaslar, Radu Marches, Lisa Kenyon-Pesce, Robert Rossi, Damien Chaussabel, Djamel Nehar-Belaid, David C LaFon, Virginia Pascual, Karolina Palucka, Silke Paust, Moon H Nahm, George A Kuchel, Jacques Banchereau, Duygu Ucar
Pneumococcal infections cause serious illness and death among older adults. The capsular polysaccharide vaccine PPSV23 and conjugated alternative PCV13 can prevent these infections; yet, underlying immunological responses and baseline predictors remain unknown. We vaccinated 39 older adults (>60 years) with PPSV23 or PCV13 and observed comparable antibody responses (day 28) and plasmablast transcriptional responses (day 10); however, the baseline predictors were distinct. Analyses of baseline flow cytometry and bulk and single-cell RNA-sequencing data revealed a baseline phenotype specifically associated with weaker PCV13 responses, which was characterized by increased expression of cytotoxicity-associated genes, increased frequencies of CD16+ natural killer cells and interleukin-17-producing helper T cells and a decreased frequency of type 1 helper T cells...
January 5, 2024: Nature Immunology
#7
JOURNAL ARTICLE
Estefanía Chamorro-Aguirre, Virginia L Gaveglio, Ana C Pascual, Susana J Pasquaré
We previously reported that 2-arachidonoylglycerol (2-AG) synthesis by diacylglycerol lipase (DAGL) and lysophosphatidate phosphohydrolase (LPAP) and hydrolysis by monoacylglycerol lipase (MAGL) in rod outer segments (ROS) from bovine retina were differently modified by light applied to the retina. Based on these findings, the aim of the present research was to evaluate whether 2-AG metabolism could be modulated by proteins involved in the visual process. To this end, ROS kept in darkness (DROS) or obtained in darkness and then subjected to light (BROS) were treated with GTPγS and GDPβS, or with low and moderate ionic strength buffers for detaching soluble and peripheral proteins, or soluble proteins, respectively...
December 18, 2023: Molecular Neurobiology
#8
JOURNAL ARTICLE
Nima Nouri, Raquel Giacomelli Cao, Eleonora Bunsow, Djamel Nehar-Belaid, Radu Marches, Zhaohui Xu, Bennett Smith, Santtu Heinonen, Sara Mertz, Amy Leber, Gaby Smits, Fiona van der Klis, Asunción Mejías, Jacques Banchereau, Virginia Pascual, Octavio Ramilo
Infants necessitate vaccinations to prevent life-threatening infections. Our understanding of the infant immune responses to routine vaccines remains limited. We analyzed two cohorts of 2-month-old infants before vaccination, one week, and one-month post-vaccination. We report remarkable heterogeneity but limited antibody responses to the different antigens. Whole-blood transcriptome analysis in an initial cohort showed marked overexpression of interferon-stimulated genes (ISGs) and to a lesser extent of inflammation-genes at day 7, which normalized one month post-vaccination...
December 2, 2023: Nature Communications
#9
REVIEW
Maria T Vassileva, Jason S Kim, Alejandro Gonzalez Della Valle, Michael D Harris, Valentina Pedoia, Riccardo Lattanzi, Virginia Byers Kraus, Cecilia Pascual-Garrido, Mathias P Bostrom
Far more publications are available for osteoarthritis of the knee than of the hip. Recognizing this research gap, the Arthritis Foundation (AF), in partnership with the Hospital for Special Surgery (HSS), convened an in-person meeting of thought leaders to review the state of the science of and clinical approaches to hip osteoarthritis. This article summarizes the recommendations gleaned from 5 presentations given in the "early hip osteoarthritis" session of the 2023 Hip Osteoarthritis Clinical Studies Conference, which took place on February 17 and 18, 2023, in New York City...
November 2023: HSS Journal: the Musculoskeletal Journal of Hospital for Special Surgery
#10
JOURNAL ARTICLE
Ainize Peña-Cearra, Janire Castelo, Jose Luis Lavín, Monika Gonzalez-Lopez, Miguel Angel Pascual-Itoiz, Miguel Fuertes, Virginia Gutiérrez de Juan, Laura Bárcena, Itziar Martín-Ruiz, Aize Pellón, Iratxe Seoane, Diego Barriales, Ainhoa Palacios, Asier Fullaondo, Iago Rodríguez-Lago, María L Martinez-Chantar, Ana Mª Aransay, Hector Rodriguez, Juan Anguita, Leticia Abecia
Anti-TNF therapy can induce and maintain a remission status during intestinal bowel disease. However, up to 30% of patients do not respond to this therapy by mechanisms that are unknown. Here, we show that the absence of MCJ, a natural inhibitor of the respiratory chain Complex I, induces gut microbiota changes that are critical determinants of the lack of response in a murine model of DSS-induced inflammation. First, we found that MCJ expression is restricted to macrophages in human colonic tissue. Therefore, we demonstrate by transcriptomic analysis of colon macrophages from DSS-induced mice that MCJ-deficiency is linked to the expression of genes belonging to the FcγR signaling pathway and contains an anti-TNF refractory gene signature identified in ulcerative colitis patients...
December 2023: Gut Microbes
#11
REVIEW
César Serrano, Javier Martín-Broto, José Manuel Asencio-Pascual, José Antonio López-Guerrero, Jordi Rubió-Casadevall, Silvia Bagué, Xavier García-Del-Muro, Juan Ángel Fernández-Hernández, Luís Herrero, Antonio López-Pousa, Andrés Poveda, Virginia Martínez-Marín
Gastrointestinal stromal tumor (GIST) is the most common malignant neoplasm of mesenchymal origin. GIST spans a wide clinical spectrum that ranges from tumors with essentially no metastatic potential to malignant and life-threatening spread diseases. Gain-of-function mutations in KIT or PDGFRA receptor tyrosine kinases are the crucial drivers of most GISTs, responsible for tumor initiation and evolution throughout the entire course of the disease. The introduction of tyrosine kinase inhibitors targeting these receptors has substantially improved the outcomes in this formerly chemoresistant cancer...
2023: Therapeutic Advances in Medical Oncology
#12
JOURNAL ARTICLE
Jin-Gyu Cheong, Arjun Ravishankar, Siddhartha Sharma, Christopher N Parkhurst, Simon A Grassmann, Claire K Wingert, Paoline Laurent, Sai Ma, Lucinda Paddock, Isabella C Miranda, Emin Onur Karakaslar, Djamel Nehar-Belaid, Asa Thibodeau, Michael J Bale, Vinay K Kartha, Jim K Yee, Minh Y Mays, Chenyang Jiang, Andrew W Daman, Alexia Martinez de Paz, Dughan Ahimovic, Victor Ramos, Alexander Lercher, Erik Nielsen, Sergio Alvarez-Mulett, Ling Zheng, Andrew Earl, Alisha Yallowitz, Lexi Robbins, Elyse LaFond, Karissa L Weidman, Sabrina Racine-Brzostek, He S Yang, David R Price, Louise Leyre, André F Rendeiro, Hiranmayi Ravichandran, Junbum Kim, Alain C Borczuk, Charles M Rice, R Brad Jones, Edward J Schenck, Robert J Kaner, Amy Chadburn, Zhen Zhao, Virginia Pascual, Olivier Elemento, Robert E Schwartz, Jason D Buenrostro, Rachel E Niec, Franck J Barrat, Lindsay Lief, Joseph C Sun, Duygu Ucar, Steven Z Josefowicz
Inflammation can trigger lasting phenotypes in immune and non-immune cells. Whether and how human infections and associated inflammation can form innate immune memory in hematopoietic stem and progenitor cells (HSPC) has remained unclear. We found that circulating HSPC, enriched from peripheral blood, captured the diversity of bone marrow HSPC, enabling investigation of their epigenomic reprogramming following coronavirus disease 2019 (COVID-19). Alterations in innate immune phenotypes and epigenetic programs of HSPC persisted for months to 1 year following severe COVID-19 and were associated with distinct transcription factor (TF) activities, altered regulation of inflammatory programs, and durable increases in myelopoiesis...
August 31, 2023: Cell
#13
JOURNAL ARTICLE
Pablo Salinas, Tamara García-Camarero, Marcelo Jimenez-Kockar, Ander Regueiro, Sergio García-Blas, Antonio E Gomez-Menchero, Soledad Ojeda, Jean Paul Vilchez-Tschischke, Ignacio Amat-Santos, Jose Luis Díez-Gil, Juan Rondán, Fernando Lozano Ruiz-Poveda, Antonio de Miguel Castro, Maria C Manzano, Virginia Pascual-Tejerina, Ignacio Cruz-González, Javier García Perez-Velasco, Jose A Fernández-Diaz, Javier Escaned
BACKGROUND: Myocardial revascularization failure (MRF) and Secondary revascularization (SR) are contemporary interventional cardiology challenges. AIM: To investigate the characteristics, management, and prognosis of patients with myocardial revascularization failure (MRF) and need for secondary revascularization (SR) in contemporary practice. METHODS: The REVASEC study is a prospective registry (NCT03349385), which recruited patients with prior revascularization referred for coronary angiography at 19 centers...
August 15, 2023: Catheterization and Cardiovascular Interventions
#14
Simone Caielli, Preetha Balasubramanian, Juan Rodriguez-Alcazar, Uthra Balaji, Zurong Wan, Jeanine Baisch, Cynthia Smitherman, Lynnette Walters, Paola Sparagana, Djamel Nehar-Belaid, Radu Marches, Lorien Nassi, Katie Stewart, Julie Fuller, Jacques F Banchereau, Jinghua Gu, Tracey Wright, Virginia Pascual
Systemic Lupus Erythematosus (SLE) is characterized by autoreactive B cell activation, upregulation of Type I Interferon (IFN) and widespread inflammation. Mitochondrial nucleic acids (NAs) are increasingly recognized as triggers of IFN 1 . Thus, defective removal of mitochondria from mature red blood cells (Mito + RBCs), a feature of SLE, contributes to IFN production by myeloid cells 2 . Here we identify blood monocytes (Mo) that have internalized RBCs and co-express IFN-stimulated genes (ISGs) and interleukin-1β (IL-1β) in SLE patients with active disease...
August 3, 2023: bioRxiv
#15
JOURNAL ARTICLE
Virginia Pascual-Ramos, Irazú Contreras-Yáñez, Maximiliano Cuevas-Montoya, Guillermo A Guaracha-Basáñez, Cesar Mario García-Alanís, Oscar Rodríguez-Mayoral, Harvey Max Chochinov
INTRODUCTION: Dignity has rarely been explored in patients with rheumatic diseases (RMDs), which contrasts with patients´ observations that dignity is a relevant area for research focus. The study's primary objective was to adapt and validate the Mexican version of the Patient Dignity Inventory (PDI-Mx) in patients with RMDs, and to estimate the proportion of patients with distress related to perceived dignity (DPD) assessed with the PDI-Mx. METHODS: This cross-sectional study was developed in 2 phases...
2023: PloS One
#16
JOURNAL ARTICLE
Guillermo A Guaracha-Basáñez, Irazú Contreras-Yáñez, Luis E Bautista-Torres, Ana B Ortiz-Haro, Virginia Pascual-Ramos
OBJECTIVES: Sleep disorders are part of the symptomatology of rheumatoid arthritis (RA) patients and are related to disease characteristics and comorbidities. The study describes sleep quality among RA patients and identifies predictors of optimal sleep. METHODS: Patients whose data were analysed were identified from the recent-onset RA cohort initiated in 2004. In 2010, the Medical Outcome Study Sleep Scale (MOS-SS) was incorporated into the patients' assessments...
June 6, 2023: Clinical and Experimental Rheumatology
#17
JOURNAL ARTICLE
María Sánchez-Campillo, Antonio Gázquez, Ana Serrano-Munera, Marino B Arnao, Francisco Avilés-Plaza, Azahara M Garcia-Serna, José A Noguera-Velasco, Ana Martínez-López de Castro, Carmen Martínez-Graciá, Clara Suárez-Martínez, Marina Santaella-Pascual, Jesús Vioque, Carmen Montoya-Hernández, Carmen Ballesteros-Meseguer, Marisa Sánchez-Ferrer, Virginia Perez-Fernandez, Eva Morales, Luis García-Marcos, Elvira Larqué
INTRODUCTION: Most of pregnant women do not achieve the recommended dietary intake of vitamins A and E. These vitamins may counteract oxidative stress involved in some adverse perinatal outcomes. We aimed to assess the associations between maternal vitamin A and E at mid-pregnancy with both maternal and fetal outcomes and to identify possible early biomarkers during pregnancy to predict and prevent oxidative stress in the offspring. METHODS: Data on dietary and serum levels of vitamins A and E were collected from 544 pregnant women from the Nutrition in Early Life and Asthma (NELA) study, a prospective mother-child cohort set up in Spain...
June 2, 2023: Annals of Nutrition & Metabolism
#18
RANDOMIZED CONTROLLED TRIAL
Jesús Sojo-Dorado, Inmaculada López-Hernández, Alicia Hernández-Torres, Pilar Retamar-Gentil, Esperanza Merino de Lucas, Laura Escolà-Vergé, Elena Bereciartua, Elisa García-Vázquez, Vicente Pintado, Lucía Boix-Palop, Clara Natera-Kindelán, Luisa Sorlí, Nuria Borrell, Concha Amador-Prous, Evelyn Shaw, Alfredo Jover-Saenz, Jose Molina, Rosa M Martínez-Álvarez, Carlos J Dueñas, Jorge Calvo-Montes, María Lecuona, Virginia Pomar, Irene Borreguero, Virginia Palomo-Jiménez, Fernando Docobo-Pérez, Álvaro Pascual, Jesús Rodríguez-Baño
BACKGROUND: Fosfomycin is a potentially attractive option as step-down therapy for bacteraemic urinary tract infections (BUTI), but available data are scarce. Our objective was to compare the effectiveness and safety of fosfomycin trometamol and other oral drugs as step-down therapy in patients with BUTI due to MDR Escherichia coli (MDR-Ec). METHODS: Participants in the FOREST trial (comparing IV fosfomycin with ceftriaxone or meropenem for BUTI caused by MDR-Ec in 22 Spanish hospitals from June 2014 to December 2018) who were stepped-down to oral fosfomycin (3 g q48h) or other drugs were included...
July 5, 2023: Journal of Antimicrobial Chemotherapy
#19
JOURNAL ARTICLE
Oscar Rodríguez-Mayoral, Oscar Galindo-Vázquez, Marcos Espinoza-Bello, Silvia Allende-Pérez, Virginia Pascual-Ramos, Cristina Monforte-Royo
OBJECTIVES: The Schedule of Attitudes Toward Hastened Death (SAHD) has emerged as a valid and reliable tool to assess the wish to hasten death (WTHD) among patients diagnosed with advanced cancer; however, the instrument has never been culturally adapted and validated for patients in Mexico. This study sought to validate and abbreviate the SAHD tool for use among patients attending the Palliative Care Service of the Instituto Nacional de Cancerología in Mexico. METHODS: The SAHD was culturally adapted from a previously published validation in patients from Spain...
May 18, 2023: Palliative & Supportive Care
#20
Sathyabaarathi Ravichandran, Fernando Erra-Diaz, Onur E Karakaslar, Radu Marches, Lisa Kenyon-Pesce, Robert Rossi, Damien Chaussabel, Virginia Pascual, Karolina Palucka, Silke Paust, Moon H Nahm, George A Kuchel, Jacques Banchereau, Duygu Ucar
Pneumococcal infections cause serious illness and death among older adults. A capsular polysaccharide vaccine PPSV23 (Pneumovax®) and a conjugated polysaccharide vaccine PCV13 (Prevnar®) are used to prevent these infections, yet underlying responses, and baseline predictors remain unknown. We recruited and vaccinated 39 older adults (>60 years) with PPSV23 or PCV13. Both vaccines induced strong antibody responses at day 28 and similar plasmablast transcriptional signatures at day 10, however, their baseline predictors were distinct...
April 19, 2023: medRxiv
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