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cornea and anterior segment

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https://www.readbyqxmd.com/read/28097917/repeatability-of-whole-cornea-measurements-using-an-anterior-segment-imaging-device-based-on-oct-and-placido-disk
#1
Noelia Martínez-Albert, José J Esteve-Taboada, Robert Montés-Micó
AIM: To evaluate the repeatability of topographic measurements using an integrated Placido disk - OCT device. METHODS: Thirty right eyes of thirty healthy subjects aged between 20 and 30 years were included. The topographic parameters of simulated keratometry, asphericity, minimum pachymetry, white-to-white distance, spherical aberration and corneal elevation were studied. Three measurements were taken by the same observer using the Visante omni device. The coefficient of repeatability (CoR), coefficient of variation (CoV) and intraclass correlation coefficient (ICC) were calculated to assess the repeatability...
January 18, 2017: Expert Review of Medical Devices
https://www.readbyqxmd.com/read/28076560/evaluation-of-anterior-segment-parameters-using-scheimpflug-technology-during-the-valsalva-maneuver-in-patients-with-keratoconus
#2
Yusuf Koçluk, Emine Alyamaç Sukgen, Selim Cevher
Purpose: This study aimed to explore the effects of the Valsalva maneuver (VM) on ectatic corneas during anterior segment tomography scans using a Scheimpflug camera. Methods: This prospective observational study included 100 eyes of 50 patients with bilateral keratoconus (KC). Anterior segment tomography was first performed when the patients were in a resting position and immediately repeated as the participant performed VM. Scheimpflug images were taken using a Pentacam®...
November 2016: Arquivos Brasileiros de Oftalmologia
https://www.readbyqxmd.com/read/28068442/oct-study-of-the-femtosecond-laser-opaque-bubble-layer
#3
Gustavo K Marino, Marcony R Santhiago, Steven E Wilson
PURPOSE: To characterize the location and regularity of the opaque bubble layer (OBL) in the corneal stroma after femtosecond laser-assisted LASIK (FS-LASIK) flap generation. METHODS: In this prospective study, 30 eyes of 15 patients who had FS-LASIK surgery for myopia, astigmatism, and/or hyperopia were included. Screen captures were obtained at the end of the flap creation and the eyes with hard type OBL were immediately imaged with anterior segment optical coherence tomography...
January 1, 2017: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/28062421/intraoperative-oct-assisted-descemetopexy-with-stromal-vent-incisions-and-intracameral-gas-injection-for-case-of-non-resolving-descemet-s-membrane-detachment
#4
Archita Singh, Murugesan Vanathi, Suman Sahu, Saranya Devi
Descemet's membrane detachment (DMD) though uncommon in the present day scenario of advancing surgical techniques is a significant complication that requires prompt diagnosis and management. A middle-aged man presented to our hospital with poor gain of vision following cataract surgery. There was significant corneal oedema with DMD which was confirmed on anterior segment optical coherence tomography. We describe a modified continuous intraoperative-guided approach for the management of DMD in cases with oedematous hazy corneas...
January 6, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28061513/angiopoietin-2-blockade-promotes-survival-of-corneal-transplants
#5
Liwei Zhang, Guangyu Li, Roberto Sessa, Gyeong Jin Kang, Meng Shi, Shaokui Ge, Anna Jiang Gong, Ying Wen, Sudhakar Chintharlapalli, Lu Chen
Purpose: Corneal transplantation remains the last hope for vision restoration, and lymphangiogenesis (LG) is a primary mediator of transplant rejection. This study was to investigate the specific role of angiopoietin-2 (Ang-2) in transplantation-associated LG and graft rejection. Methods: Orthotopic corneal transplantation was performed between fully mismatched C57BL/6 (donor) and BALB/c (recipient) mice to assess the effects of Ang-2 blockade via neutralizing antibody...
January 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28060027/advantages-of-anterior-segment-optical-coherence-tomography-evaluation-of-the-kayser-fleischer-ring-in-wilson-disease
#6
Mittanamalli S Sridhar
PURPOSE: To present anterior segment optical coherence tomography (AS-OCT) findings of the Kayser-Fleischer (KF) ring in Wilson disease (WD) and to discuss the potential advantages of evaluating the KF ring by AS-OCT. METHODS: This is a retrospective case series of 7 patients with WD with KF rings seen in our institute during the study period (August 2015 to June 2016). All patients underwent slit-lamp examination of the cornea and AS-OCT (Optovue RTVue Premier)...
January 4, 2017: Cornea
https://www.readbyqxmd.com/read/28040524/corneal-higher-order-aberrations-in-infectious-keratitis
#7
Eisuke Shimizu, Takefumi Yamaguchi, Yukari Yaguchi, Murat Dogru, Yoshiyuki Satake, Kazuo Tsubota, Jun Shimazaki
PURPOSE: To characterize the corneal higher-order aberrations (HOAs) in eyes with acanthoamoeba keratitis (AK), bacterial keratitis (BK), and fungal keratitis (FK). DESIGN: Retrospective consecutive case series. METHODS: This retrospective study includes 18 normal subjects and 63 eyes of 62 consecutive patients with corneal scarring due to AK (20 eyes), BK (35 eyes) and FK (8 eyes) from 2010 to 2016. HOAs of the anterior and posterior surfaces and the total cornea were analyzed by anterior segment optical coherence tomography (AS-OCT)...
December 28, 2016: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28018671/accelerated-corneal-collagen-cross-linking-using-topography-guided-uv-a-energy-emission-preliminary-clinical-and-morphological-outcomes
#8
Cosimo Mazzotta, Antonio Moramarco, Claudio Traversi, Stefano Baiocchi, Alfonso Iovieno, Luigi Fontana
Purpose. To assess the clinical and morphological outcomes of topography-guided accelerated corneal cross-linking. Design. Retrospective case series. Methods. 21 eyes of 20 patients with progressive keratoconus were enrolled. All patients underwent accelerated cross-linking using an ultraviolet-A (UVA) exposure with an energy release varying from 7.2 J/cm(2) up to 15 J/cm(2), according to the topographic corneal curvature. Uncorrected (UDVA) and corrected (CDVA) distance visual acuity, topography, in vivo confocal microscopy (IVCM), and anterior segment optic coherence tomography (AS-OCT) were evaluated preoperatively and at the 1, 3, 6, and 12 months postoperatively...
2016: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28008920/acoustic-micro-tapping-for-non-contact-4d-imaging-of-tissue-elasticity
#9
Łukasz Ambroziński, Shaozhen Song, Soon Joon Yoon, Ivan Pelivanov, David Li, Liang Gao, Tueng T Shen, Ruikang K Wang, Matthew O'Donnell
Elastography plays a key role in characterizing soft media such as biological tissue. Although this technology has found widespread use in both clinical diagnostics and basic science research, nearly all methods require direct physical contact with the object of interest and can even be invasive. For a number of applications, such as diagnostic measurements on the anterior segment of the eye, physical contact is not desired and may even be prohibited. Here we present a fundamentally new approach to dynamic elastography using non-contact mechanical stimulation of soft media with precise spatial and temporal shaping...
December 23, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27993459/corneal-epithelial-bullae-after-short-term-wear-of-small-diameter-scleral-lenses
#10
Alex D Nixon, Joseph T Barr, Dean A VanNasdale
Complications of scleral lens wear are not well documented or understood. While multiple studies focus on oxygen transmission during scleral lens wear and associated corneal swelling, little is known about the effects of varying scleral lens fitting relationships, especially when there is corneal interaction. Scleral lenses, by convention, are designed to completely clear the corneal surface and rest on the conjunctival and scleral tissue. However, some designs maximize oxygen transmission by reducing the lens diameter, thickness, and recommended corneal clearance...
December 16, 2016: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/27987671/role-of-solvent-mediated-carbodiimide-cross-linking-in-fabrication-of-electrospun-gelatin-nanofibrous-membranes-as-ophthalmic-biomaterials
#11
Shih-Feng Chou, Li-Jyuan Luo, Jui-Yang Lai, David Hui-Kang Ma
Due to their ability to mimic the structure of extracellular matrix, electrospun gelatin nanofibers are promising cell scaffolding materials for tissue engineering applications. However, the hydrophilic gelatin molecules usually need stabilization before use in aqueous physiological environment. Considering that biomaterials cross-linked via film immersion technique may have a more homogeneous cross-linked structure than vapor phase cross-linking, this work aims to investigate the chemical modification of electrospun gelatin nanofibrous membranes by liquid phase carbodiimide in the presence of ethanol/water co-solvents with varying ethanol concentrations ranging from 80 to 99...
February 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27984365/mid-term-results-of-a-single-intrastromal-corneal-ring-segment-for-mild-to-moderate-progressive-keratoconus
#12
Mohammad Miraftab, Hassan Hashemi, Farhad Hafezi, Soheila Asgari
PURPOSE: To study the mid-term effects of implanting a single intracorneal ring segment (ICRS) for treatment of mild to moderate progressive keratoconus. METHODS: This retrospective study was conducted on patients with progressive keratoconus treated with ICRS. The mean follow-up time was 15.2 ± 8.8 (range, 7-26) months before and 27.8 ± 7.5 (range, 18-35) months after surgery. Patients received no other treatment during this time. Of the cases studied, 59.1% had inferior keratoconus...
December 14, 2016: Cornea
https://www.readbyqxmd.com/read/27982215/toxic-anterior-segment-syndrome-following-deep-anterior-lamellar-keratoplasty
#13
Neslihan Sevimli, Remzi Karadag, Ozgur Cakici, Huseyin Bayramlar, Seydi Okumus, Unsal Sari
We present the case of a 31-year-old patient with toxic anterior segment syndrome (TASS) that developed after undergoing deep anterior lamellar keratoplasty (DALK). She had keratoconus, and despite wearing hard contact lenses for many years in the left eye, her vision had deteriorated; therefore, DALK was performed on this eye. The preoperative visual acuity (VA) was finger counting at 3 m. Routine DALK was performed using the "big-bubble" technique. The corneal entry incision was hydrated at the end of the surgery, which was terminated by air injection into the anterior chamber...
September 2016: Arquivos Brasileiros de Oftalmologia
https://www.readbyqxmd.com/read/27941387/clinical-findings-of-anterior-segment-spectral-domain-optical-coherence-tomography-images-in-cytomegalovirus-corneal-endotheliitis
#14
Reiko Kobayashi, Noriyasu Hashida, Takeshi Soma, Shizuka Koh, Atsuya Miki, Shinichi Usui, Naoyuki Maeda, Kohji Nishida
PURPOSE: To evaluate the morphological characteristics of posterior corneal regions including keratic precipitates in eyes with cytomegalovirus (CMV) corneal endotheliitis using anterior segment spectral domain optical coherence tomography (SD-OCT). METHODS: Thirteen eyes of 13 patients with polymerase chain reaction-proven CMV corneal endotheliitis were included in this study. Slit-lamp images and anterior segment SD-OCT images of the posterior cornea were obtained to analyze the clinical characteristics of corneal structures and keratic precipitates...
December 8, 2016: Cornea
https://www.readbyqxmd.com/read/27929720/unclassified-axenfeld-rieger-syndrome-a-case-series-and-review-of-literature
#15
Aparna Rao, Debananda Padhy, Sarada Sarangi, Gopinath Das
PURPOSE: To report anterior segment features in unclassified anterior segment dysgenesis with overlapping features of Axenfeld-Rieger syndrome and other developmental anomalies. METHODS: This retrospective study included those with atypical or overlapping features in one or both eyes, which were identified as unclassified ASD. Typical ARS was defined as the presence of posterior embryotoxon with or without iris changes like stromal hypoplasia, corectopia, polycoria, or ectropion uvea with or without systemic features...
December 8, 2016: Seminars in Ophthalmology
https://www.readbyqxmd.com/read/27911424/-effectiveness-of-soft-contact-lenses-in-severe-keratoconjunctivitis-sicca-treated-with-local-immunosuppressive-therapy
#16
T N Safonova, O V Gladkova, V I Boev, A A Fedorov
AIM: To study the effectiveness of soft contact lenses in severe keratoconjunctivitis sicca (KCS) treated with local immunosuppressive therapy. MATERIAL AND METHODS: We have examined 41 patients (60 eyes) with severe KCS, including 3 men (4 eyes) and 38 women (56 eyes) aged from 27 to 76 years. Group 1 consisted of 22 persons (30 eyes) who were prescribed cyclosporine А 0.05% instillations 2 times daily, artificial tears, and soft contact lenses. Group 2 consisted of 19 patients (30 eyes) who received instillations of cyclosporine А 0...
2016: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/27896533/characteristics-of-higher-order-aberrations-and-anterior-segment-tomography-in-patients-with-pathologic-myopia
#17
Kaori Kasahara, Naoyuki Maeda, Takashi Fujikado, Makoto Tomita, Muka Moriyama, Mutsumi Fuchihata, Kyoko Ohno-Matsui
PURPOSE: To investigate prospectively the characteristics in the higher-order aberrations and anterior segment tomography in patients with pathologic myopia. METHODS: One hundred and twelve consecutive highly myopic patients (mean age 43.4 ± 9.3 years, spherical equivalent of refractive error ≥8 D and an axial length ≥26.5 mm) were studied. Thirty-seven emmetropic individuals (mean age 37.0 ± 14.5 years, spherical equivalent of refractive error ≤ ±1 D) were analyzed as controls...
November 28, 2016: International Ophthalmology
https://www.readbyqxmd.com/read/27860529/a-comparison-of-central-corneal-thicknesses-measured-with-two-different-methods-in-cases-of-primary-open-angle-glaucoma
#18
Fatih Mehmet Adibelli, Halit Oğuz, Tuğba Göncü, Omer Faruk Yilmaz, Funda Yuksekyayla
Accurate and repeatable measurement of the central cornea thickness (CCT) is important in terms of follow-up of glaucoma patients. The aim of this study was to compare CCT measurements made with an ultrasonic pachymeter (USP) and with the Spectralis Anterior Segment Module optical coherence tomography (OCT) device. The study included 52 eyes of 26 primary open-angle glaucoma patients. CCT measurements were taken with the USP device and then with the OCT by imaging cornea slices. The mean CCT was measured as 555...
November 18, 2016: Seminars in Ophthalmology
https://www.readbyqxmd.com/read/27793755/topical-ophthalmic-lipid-nanoparticle-formulations-sln-nlc-of-indomethacin-for-delivery-to-the-posterior-segment-ocular-tissues
#19
Sai Prachetan Balguri, Goutham R Adelli, Soumyajit Majumdar
PURPOSE: The objective of the present study was to formulate indomethacin (IN)-loaded solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) and to investigate their potential use in topical ocular delivery. METHODS: IN SLNs (0.1% w/v) and NLCs (0.8% w/v) were prepared, characterized and evaluated. Their in vitro release and flux profiles across the cornea and sclera-choroid-RPE (trans-SCR) tissues and in vivo ocular tissue distribution were assessed...
December 2016: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/27789975/peters-plus-anomaly-in-a-cameroonian-child-a-case-report
#20
Giles Kagmeni, Yannick Bilong, Cedric Mbogos, Lucienne Bella Assumpta
BACKGROUND: Peters' anomaly (PA) is a rare form of anterior segment dysgenesis characterized by corneal opacity with varied degree of anterior chamber affection with associated defects in the posterior layers of the cornea. CASE PRESENTATION: We report the case of a 3-month-old male infant with bilateral corneal opacity since birth who was transferred from the pediatric unit for further ophthalmic care. He was diagnosed with PA with subsequent systemic-associated malformations including craniofacial defects and skeletal defects...
2016: International Medical Case Reports Journal
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