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cornea and anterior segment

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https://www.readbyqxmd.com/read/28801092/anterior-segment-optical-coherence-tomography-for-the-diagnosis-of-corneal-dystrophies-according-to-the-ic3d-classification
#1
REVIEW
Sebastian Siebelmann, Paula Scholz, Simon Sonnenschein, Björn Bachmann, Mario Matthaei, Claus Cursiefen, Ludwig M Heindl
Corneal dystrophies are categorized according to the International Committee for Classification of Corneal Dystrophies (IC3D) classification, and their treatment depends on the affected structures and layer of the cornea. Therefore, estimating the depth and extent of the morphological changes due to the specific dystrophy is crucial when deciding between different treatment options. Besides superficial laser treatments and penetrating keratoplasty, minimal invasive lamellar keratoplasties such as Descemet membrane endothelial keratoplasty), deep anterior lamellar keratoplasty, or Descemet stripping automated keratoplasty have become increasingly popular to exchange the specific opaque layers in dystrophic eyes...
August 8, 2017: Survey of Ophthalmology
https://www.readbyqxmd.com/read/28799565/modified-technique-of-endocapsular-lens-aspiration-for-severely-subluxated-lenses
#2
S Khokhar, N Aron, N Yadav, G Pillay, E Agarwal
PurposeSeverely subluxated crystalline lenses pose a difficult situation to anterior segment surgeons and can only be managed surgically by removal of the lens as well as the capsular bag. Several techniques have been described in literature for the management of such cases. We describe a modified technique of endocapsular lens aspiration by the limbal route for lens extraction through small incisions on the cornea.Patients and methodsThirty-two eyes of 16 consecutive patients with severely subluxated crystalline lenses were recruited in the study...
August 11, 2017: Eye
https://www.readbyqxmd.com/read/28777100/scleral-pneumatonometry-in-penetrating-keratoplasty-a-clinical-study
#3
Otavio A Magalhaes, Anthony J Aldave
PURPOSE: To evaluate the reliability between pneumatonometry intraocular pressure (IOP) measurement in different scleral locations and corneal IOP in a penetrating keratoplasty (PK) setting. Our aim is to validate a method that can potentially be used for patients with keratoprostheses. METHODS: This is a prospective observational study of 40 patients who underwent monocular PK by a single surgeon and had no significant anterior segment condition in the contralateral eye...
August 2, 2017: Cornea
https://www.readbyqxmd.com/read/28772298/measurement-of-gamma-irradiated-corneal-patch-graft-thickness-after-aqueous-drainage-device-surgery
#4
Regina A de Luna, Ameera Moledina, Jiangxia Wang, Henry D Jampel
Importance: Exposure of the tube of an aqueous drainage device (ADD) through the conjunctiva is a serious complication of ADD surgery. Although placement of gamma-irradiated sterile cornea (GISC) as a patch graft over the tube is commonly performed, exposures still occur. Objectives: To measure GISC patch graft thickness as a function of time after surgery, estimate the rate of graft thinning, and determine risk factors for graft thinning. Design, Setting, and Participants: Cross-sectional study of graft thickness using anterior segment optic coherence tomography (AS-OCT) was conducted at the Wilmer Eye Institute at Johns Hopkins Hospital...
August 3, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28763501/single-stranded-adeno-associated-virus-achieves-efficient-gene-transfer-to-anterior-segment-in-the-mouse-eye
#5
Li Wang, Ru Xiao, Eva Andres-Mateos, Luk H Vandenberghe
Adeno-associated viruses (AAVs) are used extensively as a gene delivery vehicle for retinal gene therapy, yet its ability to target the anterior segment of the eye, critical to unlocking therapeutic opportunities, is less characterized. Previously, self-complimentary (sc) AAV was shown to be necessary for transduction of the cornea and trabecular meshwork (TM), limiting the size of the gene transfer cassette, likely due to a block in second strand synthesis thought to be required for functional transduction...
2017: PloS One
https://www.readbyqxmd.com/read/28761328/training-time-and-quality-of-smartphone-based-anterior-segment-screening-in-rural-india
#6
Cassie A Ludwig, Megan R Newsom, Alexandre Jais, David J Myung, Somasheila I Murthy, Robert T Chang
OBJECTIVE: We aimed at evaluating the ability of individuals without ophthalmologic training to quickly capture high-quality images of the cornea by using a smartphone and low-cost anterior segment imaging adapter (the "EyeGo" prototype). METHODS: Seven volunteers photographed 1,502 anterior segments from 751 high school students in Varni, India, by using an iPhone 5S with an attached EyeGo adapter. Primary outcome measures were median photograph quality of the cornea and anterior segment of the eye (validated Fundus Photography vs Ophthalmoscopy Trial Outcomes in the Emergency Department [FOTO-ED] study; 1-5 scale; 5, best) and the time required to take each photograph...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28752695/changes-in-tear-volume-after-3-diquafosol-treatment-in-patients-with-dry-eye-syndrome-an-anterior-segment-spectral-domain-optical-coherence-tomography-study
#7
Kwan Bok Lee, Kyung Min Koh, Young A Kwon, Sang Wroul Song, Byoung Yeop Kim, Jae Lim Chung
PURPOSE: To evaluate changes in the tear meniscus area and tear meniscus height over time in patients with dry eye syndrome, using anterior segment spectral-domain optical coherence tomography after the instillation of 3% diquafosol ophthalmic solution. METHODS: Sixty eyes from 30 patients with mild to moderate dry eye syndrome were included. Tear meniscus images acquired by anterior segment spectral-domain optical coherence tomography were analyzed using National Institutes of Health's image-analysis software (ImageJ 1...
August 2017: Korean Journal of Ophthalmology: KJO
https://www.readbyqxmd.com/read/28747621/evaluation-of-biomechanical-changes-in-myopia-patients-with-unsatisfactory-corneas-after-femto-second-laser-in-situ-keratomileusis-fs-lasik-concurrent-with-accelerated-corneal-collagen-cross-linking-using-corvis-st-two-year-follow-up-results
#8
Weiwei Xu, Ye Tao, Liqiang Wang, Yifei Huang
BACKGROUND Some myopia patients with unsatisfactory corneas consider corneal refractive surgery for different reasons. Accelerated corneal collagen crosslinking (ACXL) is an effective method to enhance the resistance of the cornea. The present investigation was designed to evaluate the changes of biomechanical properties in patients with myopia and thin corneas after femtosecond-laser in situ keratomileusis (FS-LASIK) concurrent with ACXL. MATERIAL AND METHODS A prospective study was designed. A total of 22 eyes of 11 myopia astigmatism patients with unsatisfactory corneas were enrolled...
July 27, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28746174/traumatic-cataract-in-patient-with-anterior-megalophthalmos-case-report
#9
Edyta Chlasta-Twardzik, Anna Nowińska, Paweł Wąs, Agnieszka Jakubowska, Edward Wylęgała
RATIONALE: Megalophthalmos anterior is a rare, bilateral, nonprogressive, hereditary, congenital disorder, characterized by the enlargement of all anterior segment structures of the eye, with megalocornea, iris atrophy, and zonular abnormalities commonly found. Usually almost asymptomatic in young patients, with most complaints concerning blurred vision due to the common corneal astigmatism, it might in time lead to several complications including premature cataract formation and pigmentary glaucoma...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28736046/the-optical-imaging-of-tarantula-hair-corneal-injury-one-case-report-and-review-of-the-literature
#10
Yuedong Hu, Yuanyuan Xu
INTRODUCTION: Tarantulas belonging to the Theraphosidae family are more and more popular as family pets. Ocular injuries caused by tarantulas are reported in several articles. We hereby report the first known case of ocular injury caused by a tarantula in China. CASE: A 22-year-old girl was referred to our hospital with one-week history of red and irritated left eye after she grabbed her molting Chilean Rose Tarantula. Her best-corrected visual acuity was 20/20 on both eyes...
July 20, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28728288/-descemet-s-membrane-endothelial-keratoplasty-for-treatment-of-patients-with-corneal-endothelial-decompensation
#11
T Huang, C Ouyang, J Zhan, L Jiang
Objective: To evaluate the clinical outcomes of Descemet's membrane endothelial keratoplasty (DMEK) for treatment of patients with corneal endothelial decompensation in China. Methods: Interventional case series. Ten patients (10 eyes) with the diagnosis of corneal endothelial decompensation received DMEK during July 2016 and September 2016 in Zhongshan Ophthalmic Center. Descemet's membrane of the donor tissue was carefully stripped from the underlying stroma manually and cut with a 7.75- or 8.0-mm-diameter donor punch...
July 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28724820/a-rare-case-of-cleft-number-nine-associated-with-atypical-cleft-number-two
#12
Shivanand Chanabasu Bubanale, Santosh B Kurbet, Linda Maria Genoveva De Piedade Sequeira
The incidence of the craniofacial cleft is rare ranging between 1.43 and 4.85/100,000 births. Tessier number nine cleft being the rarest, there are a few reports of detailed ophthalmologic examinations performed in them. In this study, 1-day-old female neonate delivered by normal vaginal delivery at term, weighing 1480 g presented with right eye dystopia, cleft extending through the lateral third of the upper eyelid, brow ending at the temporal region, conjunctival congestion, clear cornea 10 mm in diameter, normal anterior chamber, pupil 2 mm reactive to light, clear lens, and normal fundus...
July 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28704321/observation-of-retrocorneal-plaques-in-patients-with-infectious-keratitis-using-anterior-segment-optical-coherence-tomography
#13
Yuki Takezawa, Takashi Suzuki, Atsushi Shiraishi
PURPOSE: Endothelial plaques are a typical characteristic in patients with fungal keratitis. However, bacterial keratitis and herpetic keratouveitis are rarely associated with fibrin formation on the retrocorneal surface. This study was conducted to examine plaques attached to the endothelium in patients with infectious keratitis using anterior segment optical coherence tomography (AS-OCT). METHODS: Seventeen patients (10 women and 7 men; mean age, 75 ± 15.5 years) suspected to have infectious keratitis with retrocorneal plaques were included...
July 11, 2017: Cornea
https://www.readbyqxmd.com/read/28698011/clinical-and-morphological-manifestations-of-aniridia-associated-keratopathy-on-anterior-segment-optical-coherence-tomography-and-in-vivo-confocal-microscopy
#14
Anna Voskresenskaya, Nadezhda Pozdeyeva, Tatyana Vasilyeva, Yevgeniy Batkov, Aleksandr Shipunov, Boris Gagloev, Rena Zinchenko
PURPOSE: The study aimed to evaluate clinical and morphological changes in the limbal palisades of Vogt (POV) at different stages of aniridia-associated keratopathy (AAK) and to assess possible utility of anterior segment optical coherence tomography (AS-OCT) for the visualization of limbal progenitor structures as it correlates to laser scanning confocal microscopy (LSCM) data. METHODS: The study involved 32 patients (59 eyes) with congenital aniridia. AAK stage was defined based on biomicroscopy...
July 8, 2017: Ocular Surface
https://www.readbyqxmd.com/read/28687847/silk-fibroin-films-for-corneal-endothelial-regeneration-transplant-in-a-rabbit-descemet-membrane-endothelial-keratoplasty
#15
Natalia Vázquez, Carlos A Rodríguez-Barrientos, Salvador D Aznar-Cervantes, Manuel Chacón, José L Cenis, Ana C Riestra, Ronald M Sánchez-Avila, Mairobi Persinal, Agustín Brea-Pastor, Luis Fernández-Vega Cueto, Álvaro Meana, Jesús Merayo-Lloves
Purpose: Develop a silk fibroin (SF)-based artificial endothelial graft for its use in a rabbit Descemet membrane endothelial keratoplasty (DMEK). Methods: Human and rabbit artificial corneal endothelial grafts were developed through the culture of human and rabbit corneal endothelial cells (CECs) on SF films. Rabbit artificial SF endothelial grafts were transplanted in a DMEK surgery into a rabbit in vivo model. Results: SF artificial endothelial grafts showed the characteristic endothelial markers: zonula occludens (ZO-1) and Na+/K+ ATPase...
July 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28674834/intraocular-silicone-implant-to-treat-chronic-ocular-hypotony-an-in-vivo-trial
#16
Wesal Bayoudh, Dörthe Carstesen, Peter Walter, Andreas W A Weinberger
PURPOSE: The management of chronic ocular hypotony and complicated proliferative vitreoretinopathy-related retinal detachment represents a challenge. Being non-absorbable and non-biodegradable, a silicone oil implant is expected to restore the volume and the intraocular pressure of the globe, as well as to approximate the detached retina. Further advantages could be a long-term tamponade potential, absence of toxicity, and prevention of silicone oil emulsification or anterior chamber oil-prolapse...
July 3, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28664236/alterations-in-biomechanical-properties-of-the-cornea-among-patients-with-polycystic-kidney-disease
#17
Kubra Serefoglu Cabuk, Bennur Esen, Kursat Atalay, Ahmet Kirgiz, Rukiye Aydin
PURPOSE: The aim of this study was to evaluate the corneal biomechanical features in polycystic kidney disease (PKD) patients and compare them with the healthy individuals. METHODS: Totally 81 patients with a mean age of 48.46 ± 14.51 years and 60 control cases with a mean age of 44.68 ± 12.69 years were included in the study. All of the subjects underwent a complete ophthalmological examination, including visual acuity testing, biomicroscopic anterior and posterior segment examinations...
June 29, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28644236/cyp1b1-cytopathy-uncommon-phenotype-of-a-homozygous-cyp1b1-deletion-as-internal-corneal-ulcer-of-von-hippel
#18
Valeria Oliva-Biénzobas, Alejandro Navas, Mirena C Astiazarán, Oscar Francisco Chacón-Camacho, Jose A Bermúdez-Magner, Mariana Takane, Enrique Graue-Hernández, Juan Carlos Zenteno
PURPOSE: To report a mutation of CYP1B1 in a newborn with a rare phenotype without the classic features of anterior segment dysgenesis or congenital glaucoma. METHODS: The newborn presented with diffuse corneal edema and bilaterally elevated intraocular pressure (IOP). Ophthalmological examination, ultrasound, and ultrasound biomicroscopy were performed; congenital infections were ruled out. Genetic analysis was performed. The patient underwent penetrating keratoplasty and goniotomy in a single surgical time...
June 21, 2017: Cornea
https://www.readbyqxmd.com/read/28632845/iris-malformation-and-anterior-segment-dysgenesis-in-mice-and-humans-with-a-mutation-in-pi-3-kinase
#19
Marie H Solheim, Allen C Clermont, Jonathon N Winnay, Erlend Hallstensen, Anders Molven, Pål R Njølstad, Eyvind Rødahl, C Ronald Kahn
Purpose: To determine the ocular consequences of a dominant-negative mutation in the p85α subunit of phosphatidylinositol 3-kinase (PIK3R1) using a knock-in mouse model of SHORT syndrome, a syndrome associated with short stature, lipodystrophy, diabetes, and Rieger anomaly in humans. Methods: We investigated knock-in mice heterozygous for the SHORT syndrome mutation changing arginine 649 to tryptophan in p85α (PIK3R1) using physical examination, optical coherence tomography (OCT), tonometry, and histopathologic sections from paraffin-embedded eyes, and compared the findings to similar investigations in two human subjects with SHORT syndrome heterozygous for the same mutation...
June 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28630786/ophthoselfie-detailed-self-imaging-of-cornea-and-anterior-segment-by-smartphone
#20
Abdullah Kaya
OBJECTIVES: To describe the ophthoselfie, a method by which everyone can take detailed self-images of the cornea and anterior segment with a smartphone. MATERIALS AND METHODS: A 90-diopter non-contact double aspheric lens was attached to posterior camera of the smartphone by clear tape. Images of one eye on the screen of the smartphone could be seen with the other eye in the mirror and images were taken. RESULTS: Accurate and detailed images of the cornea and anterior segment of the eye could be taken...
June 2017: Turkish Journal of Ophthalmology
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