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gregory lewis

Kayle Shapero, James Deluca, Miranda Contursi, Meagan Wasfy, Rory B Weiner, Gregory D Lewis, Adolph Hutter, Aaron L Baggish
BACKGROUND: Masters athletes (MAs), people over the age of 35 that participate in competitive sports, are a rapidly growing population that may be uniquely at risk for cardiovascular (CV) disease. The objective of this study was to develop a comprehensive clinical CV profile of MA. METHODS: An electronic Internet-based survey (survey response rate = 66 %) was used to characterize a community cohort of MAs residing in Eastern Massachusetts, USA. Clinical and lifestyle factors associated with prevalent CV disease were determined using logistic regression...
December 2016: Sports Medicine—Open
H Mike Kim, Colin R Andrews, Evan P Roush, Gregory I Pace, Gregory S Lewis
BACKGROUND: Double-strand lateral ulnar collateral ligament (LUCL) reconstruction is an effective treatment for posterolateral rotatory instability (PLRI) of the elbow, but anatomic landmarks for ulnar tunnel placement are often difficult to identify intraoperatively, which potentially can result in a nonanatomic LUCL reconstruction. This study investigated the effect of ulnar tunnel location on joint stability in double-strand LUCL reconstruction. METHODS: PLRI was artificially created in 7 cadaveric elbows, and double-strand LUCL reconstruction was performed...
October 10, 2016: Journal of Shoulder and Elbow Surgery
Alexander E Weber, Benjamin D Kuhns, Gregory L Cvetanovich, Paul B Lewis, Richard C Mather, Michael J Salata, Shane J Nho
PURPOSE: The purpose of this study was to examine the hip capsule in a subset of symptomatic patients who underwent capsular closure during hip arthroscopy. METHODS: All patients undergoing primary hip arthroscopy for femoroacetabular impingement (FAI) with routine capsular closure between January 1, 2012, and December 31, 2015, were eligible. Only patients with unilateral surgery and a postoperative magnetic resonance imaging (MRI; ordered for persistent symptoms) were included...
October 5, 2016: Arthroscopy: the Journal of Arthroscopic & related Surgery
Michael G Stanford, Kyle Mahady, Brett B Lewis, Jason D Fowlkes, Shida Tan, Richard H Livengood, Gregory A Magel, Thomas M Moore, Philip D Rack
Focused helium ion (He+) milling has been demonstrated as a high-resolution nanopatterning technique, however it can be limited by its low sputter yield as well as the introduction of undesired sub-surface damage. Here, we introduce pulsed laser and gas assisted processes to enhance the material removal rate and patterning fidelity. A pulsed laser-assisted He+ milling process is shown to enable high resolution milling of titanium while reducing sub-surface damage in situ. Gas-assisted focused ion beam induced etching (FIBIE) of Ti is also demonstrated in which the XeF2 precursor provides a chemical assist for enhanced material removal rate...
October 4, 2016: ACS Applied Materials & Interfaces
Hani Bagheri, Chansonette Badduke, Ying Qiao, Rita Colnaghi, Iga Abramowicz, Diana Alcantara, Christopher Dunham, Jiadi Wen, Robert S Wildin, Malgorzata J M Nowaczyk, Jennifer Eichmeyer, Anna Lehman, Bruno Maranda, Sally Martell, Xianghong Shan, Suzanne M E Lewis, Mark O'Driscoll, Cheryl Y Gregory-Evans, Evica Rajcan-Separovic
The 2p15p16.1 microdeletion syndrome has a core phenotype consisting of intellectual disability, microcephaly, hypotonia, delayed growth, common craniofacial features, and digital anomalies. So far, more than 20 cases of 2p15p16.1 microdeletion syndrome have been reported in the literature; however, the size of the deletions and their breakpoints vary, making it difficult to identify the candidate genes. Recent reports pointed to 4 genes (XPO1, USP34, BCL11A, and REL) that were included, alone or in combination, in the smallest deletions causing the syndrome...
March 17, 2016: JCI Insight
Kelly A Mills, Zoltan Mari, Catherine Bakker, Vanessa Johnson, Gregory M Pontone, Alexander Pantelyat, Juan C Troncoso, Olga Pletnikova, Ted M Dawson, Liana S Rosenthal
INTRODUCTION: Gait impairment in Parkinson's Disease (PD) is often severely disabling, yet frequently remains refractory to treatment. The locus coeruleus (LC) has diffuse noradrenergic projections that are thought to play a role in gait function. Enhancement of norepinephrine transmission may improve gait in some PD patients. We hypothesized that the severity of PD pathology, and more specifically, Lewy bodies and neuronal loss in the LC, would correlate with the severity of gait dysfunction in PD...
September 25, 2016: Parkinsonism & related Disorders
Scott A Stout, Shahrokh Rouhani, Bo Liu, Jacob Oehrig, Robert W Ricker, Gregory Baker, Christopher Lewis
The lateral and vertical extents of Macondo oil in deep-sea sediments resulting from the 2010 Deepwater Horizon oil spill were determined using chemical forensics and geostatistical kriging of data from 2397 sediment samples from 875 cores collected in 2010/2011 and 2014. The total mass of Macondo-derived hopane on the seafloor in 2010/2011 was conservatively estimated between 2.00 and 2.26metric tons, derived from 219,000 to 247,000barrels of oil; or 6.9 to 7.7% of the 3.19millionbarrels spilled. Macondo-derived hopane was deposited over 1030 to 1910km(2) of the seafloor, mostly (>97%) in surface (0-1cm) and near-surface (1-3cm) sediments, which is consistent with short-term oil deposition...
September 24, 2016: Marine Pollution Bulletin
Gregory M Freisinger, Erin E Hutter, Jacqueline Lewis, Jeffrey F Granger, Andrew H Glassman, Matthew D Beal, Xueliang Pan, Laura C Schmitt, Robert A Siston, Ajit M W Chaudhari
Increased varus-valgus laxity has been reported in individuals with knee osteoarthritis (OA) compared to controls. However, the majority of previous investigations may not report truly passive joint laxity, as their tests have been performed on conscious participants who could be guarding against motion with muscle contraction during laxity evaluation. The purpose of this study was to investigate how a measure of passive knee laxity, recorded when the participant is under anesthesia, is related to varus-valgus excursion during gait, clinical measures of performance, perceived instability, and self-reported function in participants with severe knee OA...
September 24, 2016: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
Lena M Napolitano, Thomas W Biester, Gregory J Jurkovich, Jo Buyske, Mark A Malangoni, Frank R Lewis
BACKGROUND: There are no specific Accreditation Council for Graduate Medical Education General Surgery Residency Program Requirements for rotations in surgical critical care (SCC), trauma, and burn. We sought to determine the experience of general surgery residents in SCC, trauma, and burn rotations. METHODS: Data analysis of surgical rotations of American Board of Surgery general surgery resident applicants (n = 7,299) for the last 8 years (2006 to 2013, inclusive) was performed through electronic applications to the American Board of Surgery Qualifying Examination...
October 2016: American Journal of Surgery
B Kettle, T Dzelzainis, S White, L Li, B Dromey, M Zepf, C L S Lewis, G Williams, S Künzel, M Fajardo, H Dacasa, Ph Zeitoun, A Rigby, G Gregori, C Spindloe, R Heathcote, D Riley
The collisional (or free-free) absorption of soft x rays in warm dense aluminium remains an unsolved problem. Competing descriptions of the process exist, two of which we compare to our experimental data here. One of these is based on a weak scattering model, another uses a corrected classical approach. These two models show distinctly different behaviors with temperature. Here we describe experimental evidence for the absorption of 26-eV photons in solid density warm aluminium (T_{e}≈1 eV). Radiative x-ray heating from palladium-coated CH foils was used to create the warm dense aluminium samples and a laser-driven high-harmonic beam from an argon gas jet provided the probe...
August 2016: Physical Review. E
Hau-Tieng Wu, Gregory F Lewis, Maria I Davila, Ingrid Daubechies, Stephen W Porges
BACKGROUND: With recent advances in sensor and computer technologies, the ability to monitor peripheral pulse activity is no longer limited to the laboratory and clinic. Now inexpensive sensors, which interface with smartphones or other computer-based devices, are expanding into the consumer market. When appropriate algorithms are applied, these new technologies enable ambulatory monitoring of dynamic physiological responses outside the clinic in a variety of applications including monitoring fatigue, health, workload, fitness, and rehabilitation...
October 17, 2016: Methods of Information in Medicine
Gregory A Fabiano, Nicole K Schatz, Karen L Morris, Michael T Willoughby, Rebecca K Vujnovic, Kevin F Hulme, Jessica Riordan, Marlana Howard, Dwight Hennessy, Kemper Lewis, Larry Hawk, Amanda Wylie, William E Pelham
Objective: Teenage drivers diagnosed with attention-deficit/hyperactivity disorder (ADHD) are at significant risk for negative driving outcomes related to morbidity and mortality. However, there are few viable psychosocial treatments for teens with ADHD and none focus on the key functional area of driving. The Supporting the Effective Entry to the Roadway (STEER) program was evaluated in a clinical trial to investigate whether it improved family functioning as a proximal outcome and driving behavior as a distal outcome...
September 12, 2016: Journal of Consulting and Clinical Psychology
Oana L Klein, Larissa Aviles-Santa, Jianwen Cai, Harold R Collard, Alka M Kanaya, Robert C Kaplan, Gregory L Kinney, Eliana Mendes, Lewis Smith, Gregory Talavera, Donghong Wu, Martha Daviglus
OBJECTIVE: Type 2 diabetes mellitus (DM) has been associated with lung dysfunction, but this association has not been explored in Hispanics/Latinos. The relation between diabetic nephropathy and lung function and symptoms has not been explored. RESEARCH DESIGN AND METHODS: The Hispanic Community Health Study/Study of Latinos, a large, multicenter, observational study, recruited 16,415 participants aged 18-74 years (14,455 with complete data on variables of interest), between 2008 and 2011 from four U...
September 9, 2016: Diabetes Care
Laurel Hourani, Stephen Tueller, Paul Kizakevich, Gregory Lewis, Laura Strange, Belinda Weimer, Stephanie Bryant, Ellen Bishop, Robert Hubal, James Spira
The objective of this pilot study was to design, develop, and evaluate a predeployment stress inoculation training (PRESIT) preventive intervention to enable deploying personnel to cope better with combat-related stressors and mitigate the negative effects of trauma exposure. The PRESIT program consisted of three predeployment training modules: (1) educational materials on combat and operational stress control, (2) coping skills training involving focused and relaxation breathing exercises with biofeedback, and (3) exposure to a video multimedia stressor environment to practice knowledge and skills learned in the first two modules...
September 2016: Military Medicine
Susana Izquierdo, Stéphanie Essafi, Iker Del Rosal, Pietro Vidossich, Roser Pleixats, Adelina Vallribera, Gregori Ujaque, Agustí Lledós, Alexandr Shafir
The use of the hypervalent iodine reagents in oxidative processes has become a staple in modern organic synthesis. Frequently, the reactivity of λ(3) iodanes is further enhanced by acids (Lewis or Brønsted). The origin of such activation, however, has remained elusive. Here, we use the common combination of PhI(OAc)2 with BF3·Et2O as a model to fully explore this activation phenomenon. In addition to the spectroscopic assessment of the dynamic acid-base interaction, for the first time the putative PIDA·BF3 complex has been isolated and its structure determined by X-ray diffraction...
October 5, 2016: Journal of the American Chemical Society
Kathleen R Bell, Jesse R Fann, Jo Ann Brockway, Wesley R Cole, Nigel E Bush, Sureyya Dikmen, Tessa Hart, Ariel J Lang, Gerald Grant, Gregory Gahm, Mark A Reger, Jef St De Lore, Joan Machamer, Karin Ernstrom, Rema Raman, Sonia Jain, Murray B Stein, Nancy Temkin
Mild traumatic brain injury (mTBI) is a common injury for service members in recent military conflicts. There is insufficient evidence of how best to treat the consequences of mTBI. In a randomized, clinical trial, we evaluated the efficacy of telephone-delivered problem-solving treatment (PST) on psychological and physical symptoms in 356 post-deployment active duty service members from Joint Base Lewis McChord, Washington, and Fort Bragg, North Carolina. Members with medically confirmed mTBI sustained during deployment to Iraq and Afghanistan within the previous 24 months received PST or education-only (EO) interventions...
October 13, 2016: Journal of Neurotrauma
Ju Dong Yang, Sean F Altekruse, Mindie H Nguyen, Gregory J Gores, Lewis R Roberts
BACKGROUND: There is global variation in the onset of hepatocellular carcinoma (HCC). The objective of the current study was to investigate the impact of country of birth on age at the time of HCC diagnosis in the United States. METHODS: Incident HCC cases diagnosed between 2000 and 2012 in the Surveillance, Epidemiology, and End Results program 18 registry were included. Factors associated with very early onset (age at diagnosis < 40 years) and early onset (age at diagnosis < 50 years) were identified by logistic regression...
August 29, 2016: Cancer
Klemens Hoegenauer, Nicolas Soldermann, Frédéric Stauffer, Pascal Furet, Nadege Graveleau, Alexander B Smith, Christina Hebach, Gregory J Hollingworth, Ian Lewis, Sascha Gutmann, Gabriele Rummel, Mark Knapp, Romain M Wolf, Joachim Blanz, Roland Feifel, Christoph Burkhart, Frédéric Zécri
Inhibition of the lipid kinase PI3Kδ is a promising principle to treat B and T cell driven inflammatory diseases. Using a scaffold deconstruction-reconstruction strategy, we identified 4-aryl quinazolines that were optimized into potent PI3Kδ isoform selective analogues with good pharmacokinetic properties. With compound 11, we illustrate that biochemical PI3Kδ inhibition translates into modulation of isoform-dependent immune cell function (human, rat, and mouse). After oral administration of compound 11 to rats, proximal PD markers are inhibited, and dose-dependent efficacy in a mechanistic plaque forming cell assay could be demonstrated...
August 11, 2016: ACS Medicinal Chemistry Letters
Ian R H Rockett, Christa L Lilly, Haomiao Jia, Gregory L Larkin, Ted R Miller, Lewis S Nelson, Kurt B Nolte, Sandra L Putnam, Gordon S Smith, Eric D Caine
Importance: Fatal self-injury in the United States associated with deliberate behaviors is seriously underestimated owing to misclassification of poisoning suicides and mischaracterization of most drug poisoning deaths as "accidents" on death certificates. Objective: To compare national trends and patterns of self-injury mortality (SIM) with mortality from 3 proximally ranked top 10 causes of death: diabetes, influenza and pneumonia, and kidney disease. Data, Setting, and Participants: Underlying cause-of-death data from 1999 to 2014 were extracted for this observational study from death certificate data in the US Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research online databases...
October 1, 2016: JAMA Psychiatry
Hwabok Wee, J Spence Reid, Vernon M Chinchilli, Gregory S Lewis
Internal fixation of bone fractures using plates and screws involves many choices-implant type, material, sizes, and geometric configuration-made by the surgeon. These decisions can be important for providing adequate stability to promote healing and prevent implant mechanical failure. The purpose of this study was to develop mathematical models of the relationships between fracture fixation construct parameters and resulting 3D biomechanics, based on parametric computer simulations. Finite element models of hundreds of different locked plate fixation constructs for midshaft diaphyseal fractures were systematically assembled using custom algorithms, and axial, torsional, and bending loadings were simulated...
August 23, 2016: Annals of Biomedical Engineering
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