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https://www.readbyqxmd.com/read/28226527/3d-detection-of-periodic-limb-movements-in-sleep
#1
Heinrich Garn, Bernhard Kohn, Klaus Dittrich, Christoph Wiesmeyr, Gerhard Kloesch, Robert Stepansky, Markus Wimmer, Osman Ipsiroglu, Dieter Grossegger, Manuel Kemethofer, Stefan Seidel, Heinrich Garn, Bernhard Kohn, Klaus Dittrich, Christoph Wiesmeyr, Gerhard Kloesch, Robert Stepansky, Markus Wimmer, Osman Ipsiroglu, Dieter Grossegger, Manuel Kemethofer, Stefan Seidel, Christoph Wiesmeyr, Gerhard Kloesch, Heinrich Garn, Osman Ipsiroglu, Manuel Kemethofer, Robert Stepansky, Dieter Grossegger, Klaus Dittrich, Markus Wimmer, Bernhard Kohn, Stefan Seidel
The standard polysomnographic method for detecting periodic limb movements in sleep (PLMS) includes measuring the electromyography (EMG) signals from electrodes at the left and right tibialis anterior muscles. This procedure has disadvantages as the cabling affects the patients quality of sleep and the electrodes tend to come off during the night, deteriorating data quality. We used contactless monitoring of body movements by a 3D time-of-flight camera mounted above the bed. Changes in the 3D silhouette indicate motion...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226522/investigating-mechanical-properties-of-a-fabric-based-affective-haptic-display-through-electrodermal-activity-analysis
#2
Alberto Greco, Gaetano Valenza, Enzo Pasquale Scilingo, Alberto Greco, Gaetano Valenza, Enzo Pasquale Scilingo, Gaetano Valenza, Enzo Pasquale Scilingo, Alberto Greco
The aim of this study is the development of a classification system able to discern between two levels of velocity of a caress-like haptic stimulus, through information gathered from the analysis of the Electrodermal Activity (EDA) dynamics. We designed and performed an experiment where EDA signals were acquired during caress-like stimuli conveyed to 32 healthy volunteers (16 females) by means of four different fabrics (hemp, burlap, velvet and silk) and at two velocity levels (9.4 mm/s and 65 mm/s). CvxEDA model was used to process the EDA signal and extract features from both tonic and phasic components...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226520/gender-specific-automatic-valence-recognition-of-affective-olfactory-stimulation-through-the-analysis-of-the-electrodermal-activity
#3
Alberto Greco, Antonio Lanata, Gaetano Valenza, Fabio Di Francesco, Enzo Pasquale Scilingo, Alberto Greco, Antonio Lanata, Gaetano Valenza, Fabio Di Francesco, Enzo Pasquale Scilingo, Antonio Lanata, Fabio Di Francesco, Enzo Pasquale Scilingo, Alberto Greco, Gaetano Valenza
This study reports on the development of a gender-specific classification system able to discern between two valence levels of smell, through information gathered from electrodermal activity (EDA) dynamics. Specifically, two odorants were administered to 32 healthy volunteers (16 males) while monitoring EDA. CvxEDA model was used to process the EDA signal and extract features from both tonic and phasic components. The feature set was used as input to a K-NN classifier implementing a leave-one-subject-out procedure...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28225754/targeting-a-car-to-the-trac-locus-with-crispr-cas9-enhances-tumour-rejection
#4
Justin Eyquem, Jorge Mansilla-Soto, Theodoros Giavridis, Sjoukje J C van der Stegen, Mohamad Hamieh, Kristen M Cunanan, Ashlesha Odak, Mithat Gönen, Michel Sadelain
Chimeric antigen receptors (CARs) are synthetic receptors that redirect and reprogram T cells to mediate tumour rejection. The most successful CARs used to date are those targeting CD19 (ref. 2), which offer the prospect of complete remission in patients with chemorefractory or relapsed B-cell malignancies. CARs are typically transduced into the T cells of a patient using γ-retroviral vectors or other randomly integrating vectors, which may result in clonal expansion, oncogenic transformation, variegated transgene expression and transcriptional silencing...
February 22, 2017: Nature
https://www.readbyqxmd.com/read/28223092/obestatin-improves-oxidative-brain-damage-and-memory-dysfunction-in-rats-induced-with-an-epileptic-seizure
#5
Türkan Koyuncuoğlu, Caner Vızdıklar, Doğan Üren, Hakan Yılmaz, Çağan Yıldırım, Sefa Semih Atal, Dilek Akakın, Elif Kervancıoğlu-Demirci, Meral Yüksel, Berrak Ç Yeğen
Obestatin was shown to alleviate renal, gastrointestinal and haemorrhage-induced brain injury in rats. In order to investigate the neuroprotective effects of obestatin on seizure-induced oxidative brain injury, an epileptic seizure was induced with a single intraperitoneal (i.p.) dose of pentylenetetrazole (PTZ, 45mg/kg) in male Wistar rats. Thirty minutes before the PTZ injection, rats were treated with either saline or obestatin (1μg/kg, i.p.). Seizure was video-taped and then evaluated by using Racine's scoring (0-5)...
February 18, 2017: Peptides
https://www.readbyqxmd.com/read/28222100/development-of-topical-ophthalmic-in-situ-gel-forming-estradiol-delivery-system-intended-for-the-prevention-of-age-related-cataracts
#6
Udaya K Kotreka, Vicki L Davis, Moji C Adeyeye
The goal of this study was to develop and characterize an ion-activated in situ gel-forming estradiol (E2) solution eye drops intended for the prevention of age-related cataracts. Accordingly, in situ gelling eye drops were made using gellan gum as an ion-activated gel-forming polymer, polysorbate-80 as drug solubilizing agent, mannitol as tonicity agent, and combination of potassium sorbate and edetate disodium dihydrate (EDTA) as preservatives. The formulations were tested for the following characteristics: pH, clarity, osmolality, antimicrobial efficacy, rheological behavior, and in vitro drug release...
2017: PloS One
https://www.readbyqxmd.com/read/28220103/hippocampal-damage-and-atrophy-secondary-to-status-epilepticus-in-a-patient-with-schizophrenia
#7
Elaine Keiko Fujisao, Nathalia Raquel Cristaldo, Aline Marques da Silva Braga, Paulina Rodrigues Cunha, Seizo Yamashita, Luiz Eduardo Betting
A 59-year-old man was admitted with respiratory tract infection, compromised conscience and generalized tonic-clonic seizures. His medical history included schizophrenia diagnosis, for which he had been being treated since he was 27 years old. EEG disclosed non-convulsive status epilepticus. A magnetic resonance image (MRI) acquired 3 days later showed increased left hippocampal volume with hyperintensity on T2-weighted and FLAIR sequences. After being treated with antibiotics and antiepileptic medications, the patient's condition improved...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28218460/oculogyric-crises-a-review-of-phenomenology-etiology-pathogenesis-and-treatment
#8
REVIEW
Elizabeth J Slow, Anthony E Lang
Oculogyric crises are a rare movement disorder characterized by paroxysmal, conjugate, tonic, usually upwards, deviation of the eyes. Causes for oculogyric crises are limited and include complications of dopamine-receptor blocking medications and neurometabolic disorders affecting dopamine metabolism, suggesting that an underlying hypodopaminergic state is important to the pathogenesis. Mimickers of oculogyric crises exist, and we propose diagnostic criteria to distinguish true oculogyric crises. Recognition of oculogyric crises is important for the diagnosis and appropriate treatment of rare disorders, and an approach to investigations in oculogyric crises is proposed...
February 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28218416/physiology-of-midbrain-head-movement-neurons-in-cervical-dystonia
#9
Alexey Sedov, Valentin Popov, Vladimir Shabalov, Svetlana Raeva, H A Jinnah, Aasef G Shaikh
BACKGROUND: Early theories for cervical dystonia, as promoted by Hassler, emphasized the role of the midbrain interstitial nucleus of Cajal. Focus then shifted to the basal ganglia, and it was further supported with the success of deep brain stimulation. Contemporary theories suggested the role of the cerebellum, but even more recent hypotheses renewed interest in the midbrain. Although the pretectum was visited on several occasions, we still do not know about the physiology of midbrain neurons in cervical dystonia...
February 20, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28216392/nitrergic-cardiovascular-regulation-in-the-african-lungfish-protopterus-aethiopicus
#10
Renato Filogonio, William Joyce, Tobias Wang
As a ubiquitous signaling molecule, nitric oxide (NO) exerts various important effects on the cardiovascular system and is involved in the regulation of vascular tone and myocardial metabolism in vertebrates. Lungfishes are closely related to tetrapods and provide an interesting possibility to understand the transition from water to land. Lungfishes are endowed with both systemic and pulmonary circulations, and their incompletely divided ventricle allows for blood to bypass either circuit. Lungfishes inhabit ephemeral waterbodies that may enforce prolonged aestivation during drought, throughout which nitric oxide synthase (NOS) expression is upregulated...
February 16, 2017: Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
https://www.readbyqxmd.com/read/28215998/photosensitivity-in-generalized-epilepsies
#11
REVIEW
Shervonne Poleon, Jerzy P Szaflarski
Photosensitivity, which is the hallmark of photosensitive epilepsy (PSE), is described as an abnormal EEG response to visual stimuli known as a photoparoxysmal response (PPR). The PPR is a well-recognized phenomenon, occurring in 2-14% of patients with epilepsy but its pathophysiology is not clearly understood. PPR is electrographically described as 2-5Hz spike, spike-wave, or slow wave complexes with frontal and paracentral prevalence. Diagnosis of PPR is confirmed using intermittent photic stimulation (IPS) as well as video monitoring...
February 16, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28215749/steady-state-centrifugal-input-via-the-lateral-olfactory-tract-modulates-spontaneous-activity-in-the-rat-main-olfactory-bulb
#12
Neil C Ford, Edwin R Griff
Mitral and tufted cells in the main olfactory bulb (MOB) of anesthetized rats exhibit vigorous spontaneous activity, action potentials produced in the absence of odor stimuli. The central hypothesis of this paper is that tonic activity of centrifugal input to the MOB modulates the spontaneous activity of MOB neurons. The spontaneous activity of centrifugal fibers causes a baseline of steady-state neurotransmitter release, and odor stimulation produces transient changes in the resulting spontaneous activity...
February 16, 2017: Neuroscience
https://www.readbyqxmd.com/read/28210513/seizure-following-the-use-of-the-cox-2-inhibitor-etoricoxib
#13
Valentina Arnao, Marianna Riolo, Brigida Fierro, Paolo Aridon
We describe a case of epileptic seizures occurring after the use of a COX-2 inhibitor. A 61-year-old man was admitted to our department because of a generalized tonic-clonic seizure. EEG showed generalized slowdown of the activity. Neuroimaging and blood samples studies did not evidence alterations, but a careful pharmacological history revealed that the patient had taken the COX-2 inhibitor etoricoxib to treat lumbago few days before the onset of clinical symptoms. No seizures were reported after etoricoxib discontinuation and an EEG resulted to be normal two months after this...
2017: Case Reports in Neurological Medicine
https://www.readbyqxmd.com/read/28209305/initial-vasodilatation-in-a-child-with-reversible-cerebral-vasoconstriction-syndrome
#14
Yoshitsugu Oikawa, Yukimune Okubo, Yurika Numata-Uematsu, Yu Aihara, Taro Kitamura, Masaru Takayanagi, Yukitoshi Takahashi, Shigeo Kure, Mitsugu Uematsu
We describe the case of a 10-year-old boy who developed reversible cerebral vasoconstriction syndrome (RCVS) after cerebellitis. He received intravenous immunoglobulin and methylprednisolone to treat the cerebellitis. However, he then presented with a sudden severe headache, vomiting, and generalized tonic-clonic seizure. Brain magnetic resonance angiography (MRA) initially revealed diffuse cerebral vasodilatations, and diffuse multifocal segmental vasoconstrictions developed several days later. His clinical symptoms gradually resolved after several days, in the absence of any specific therapy...
February 10, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28203564/neurotoxicity-following-the-ingestion-of-bilimbi-fruit-averrhoa-bilimbi-in-an-end-stage-renal-disease-patient-on-hemodialysis
#15
Camille Pereira Caetano, Cinara Barros de Sá, Bruno Antônio Paixão Faleiros, Marcelo Fonseca Coutinho Fernandes Gomes, Edna Regina Silva Pereira
INTRODUCTION: The toxic effects of the ingestion of star fruit (Averrhoa carambola) in chronic kidney disease patients are well described in the literature. Recently, the compound caramboxin has been isolated, explaining the mechanisms of its neurotoxicity. Bilimbi fruit belongs to the family Oxalidaceae, Averrhoa bilimbi species, and exhibits similar biochemical characteristics to star fruit. OBJECTIVE: To report the case of a patient with chronic kidney disease who developed a seizure disorder after the ingestion of bilimbi fruit...
January 2017: Case Reports in Nephrology and Dialysis
https://www.readbyqxmd.com/read/28203147/astrocyte-dependent-slow-inward-currents-sics-participate-in-neuromodulatory-mechanisms-in-the-pedunculopontine-nucleus-ppn
#16
Adrienn Kovács, Balázs Pál
Slow inward currents (SICs) are known as excitatory events of neurons caused by astrocytic glutamate release and consequential activation of neuronal extrasynaptic NMDA receptors. In the present article we investigate the role of these astrocyte-dependent excitatory events on a cholinergic nucleus of the reticular activating system (RAS), the pedunculopontine nucleus (PPN). It is well known about this and other elements of the RAS, that they do not only give rise to neuromodulatory innervation of several areas, but also targets neuromodulatory actions from other members of the RAS or factors providing the homeostatic drive for sleep...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28202953/fully-human-cd19-specific-chimeric-antigen-receptors-for-t-cell-therapy
#17
D Sommermeyer, T Hill, S M Shamah, A I Salter, Y Chen, K M Mohler, S R Riddell
Impressive results have been achieved by adoptively transferring T-cells expressing CD19-specific CARs with binding domains from murine mAbs to treat B-cell malignancies. T-cell mediated immune responses specific for peptides from the murine scFv antigen-binding domain of the CAR can develop in patients and result in premature elimination of CAR-T-cells increasing the risk of tumor relapse. As fully human scFv might reduce immunogenicity, we generated CD19-specific human scFvs with similar binding characteristics as the murine FMC63-derived scFv using human Ab/DNA-libraries...
February 16, 2017: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/28199993/intraoperative-thresholds-for-capsular-stimulation-are-reliable-for-chronic-pallidal-deep-brain-stimulation-in-dystonia
#18
René Reese, Martin M Reich, Daniela Falk, Günther Deuschl, H Maximilian Mehdorn, Jens Volkmann
BACKGROUND: The threshold current for inducing muscle contractions by stimulation of pyramidal tract fibres adjacent to the globus pallidus internus (GPi) is, besides microelectrode recordings for the determination of nuclear boundaries, currently the only neurophysiological marker for intraoperative refinement of the anatomically planned target point for pallidal deep brain stimulation (GPi-DBS) in dystonia. OBJECTIVES: To determine the relationship between intraoperative thresholds for muscle contractions under general anaesthesia and postoperative thresholds in GPi-DBS...
February 16, 2017: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/28199906/aucubin-and-its-hydrolytic-derivative-attenuate-activation-of-hepatic-stellate-cells-via-modulation-of-tgf-%C3%AE-stimulation
#19
Pei-Yu Lv, Han Feng, Wei-Hua Huang, Ying-Ying Tian, Ya-Qin Wang, Yu-Hua Qin, Xiao-Hui Li, Kai Hu, Hong-Hao Zhou, Dong-Sheng Ouyang
Eucommia ulmoides is an important traditional Chinese medicine and has been used as a tonic with a long history. Aucubin is an active component extracted from Eucommia ulmoides, which has liver-protection effects. However the mechanisms are still unclear. To investigate the inhibitory effects and the underlying mechanisms of aucubin on TGF-β1-induced activation of hepatic stellate cells and ECM deposition, Human hepatic stellate cells (LX-2 cells) were incubated with TGF-β1 to evaluate the anti-fibrotic effect of aucubin...
February 8, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28197544/plasticity-in-brainstem-mechanisms-of-pain-modulation-by-nicotinic-acetylcholine-receptors-in-the-rat
#20
Francis J Jareczek, Stephanie R White, Donna L Hammond
Individuals with chronic pain may be driven to smoke more because the analgesic efficacy of nicotine diminishes. To determine whether persistent pain diminishes the actions of a nicotinic acetylcholine receptor (nAChR) agonist in pain modulatory pathways, we examined the effects of epibatidine in the rostral ventromedial medulla (RVM) of rats with and without inflammatory injury induced by intraplantar injection of complete Freund's adjuvant (CFA). In uninjured rats, epibatidine produced a dose-dependent antinociception that was completely blocked by dihydro-β-erythroidine (DHβE; α4β2 antagonist) and partially blocked by methyllycaconitine (MLA; α7 antagonist)...
January 2017: ENeuro
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