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https://www.readbyqxmd.com/read/28934127/removal-of-phenolic-compounds-from-water-using-sewage-sludge-based-activated-carbon-adsorption-a-review
#1
REVIEW
Nuhu Dalhat Mu'azu, Nabeel Jarrah, Mukarram Zubair, Omar Alagha
Due to their industrial relevance, phenolic compounds (PC) are amongst the most common organic pollutants found in many industrial wastewater effluents. The potential detrimental health and environmental impacts of PC necessitate their removal from wastewater to meet regulatory discharge standards to ensure meeting sustainable development goals. In recent decades, one of the promising, cost-effective and environmentally benign techniques for removal of PC from water streams has been adsorption onto sewage sludge (SS)-based activated carbon (SBAC)...
September 21, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28926600/publication-trends-of-research-on-diabetes-mellitus-and-t-cells-1997-2016-a-20-year-bibliometric-study
#2
Ye Gao, Yiran Wang, Xiao Zhai, Yifei He, Rong Chen, Jingjing Zhou, Ming Li, Qijin Wang
INTRODUCTION: Diabetes Mellitus (DM) is a huge burden for human health. Recent studies show the close relationship between DM and T cells. We investigated the trend in DM and T cells research. METHODS: Using the Web of Science database, we searched the publications on DM and T cells in 1997-2016, and studied the source data using bibliometric methodology. Excel 2016, GraphPad Prism 5, and VOSviewer software were used to analyze the publication trend in DM and T cells research...
2017: PloS One
https://www.readbyqxmd.com/read/28922704/direct-acting-antivirals-for-chronic-hepatitis-c
#3
REVIEW
Janus C Jakobsen, Emil Eik Nielsen, Joshua Feinberg, Kiran Kumar Katakam, Kristina Fobian, Goran Hauser, Goran Poropat, Snezana Djurisic, Karl Heinz Weiss, Milica Bjelakovic, Goran Bjelakovic, Sarah Louise Klingenberg, Jian Ping Liu, Dimitrinka Nikolova, Ronald L Koretz, Christian Gluud
BACKGROUND: Millions of people worldwide suffer from hepatitis C, which can lead to severe liver disease, liver cancer, and death. Direct-acting antivirals (DAAs), e.g. sofosbuvir, are relatively new and expensive interventions for chronic hepatitis C, and preliminary results suggest that DAAs may eradicate hepatitis C virus (HCV) from the blood (sustained virological response). Sustained virological response (SVR) is used by investigators and regulatory agencies as a surrogate outcome for morbidity and mortality, based solely on observational evidence...
September 18, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28922617/training-the-next-generation-of-biobankers-a-two-year-master-s-course-in-the-management-of-biobanks
#4
Emmanuelle Gormally, Isabelle Hardy, Elodie Caboux, Jeanne-Hélène di Donato, Pierre Hainaut, Paul Hofman
The growing complexity of biobanking requires dedicated professional staff who are trained in multiple aspects of the biobanking process, including technical, managerial, regulatory, and ethical aspects, and who have a good understanding of the challenges of biospecimen research, but also of the challenges related to the sustainability of future biobanks. Up to the present, biobanking staff have been trained in an ad-hoc manner, usually through specific short duration courses, for example, summer schools. In this article, we describe the development/establishment of a systematic 2-year training program at the Master level intended for students with a background in life sciences and providing them with a professional qualification as a "Biobank Manager...
September 18, 2017: Biopreservation and Biobanking
https://www.readbyqxmd.com/read/28922039/teaching-and-learning-activities-to-educate-nursing-students-for-interprofessional-collaboration-a-scoping-review
#5
Natalie L Murdoch, Sheila Epp, Jeanette Vinek
To prepare new graduates with the knowledge, skills, and attitudes to engage in effective interprofessional collaboration (IPC) in practice, healthcare professional programmes need to ensure their curriculum provides opportunities for interprofessional education (IPE) and IPC. To strengthen IPE within an undergraduate curriculum and meet the professional requirements set out by regulatory bodies to prepare new graduate nurses to achieve IPC competencies, a curriculum initiative was developed to expand IPE across the four years of the Baccalaureate of Science in Nursing (BSN) programme...
September 18, 2017: Journal of Interprofessional Care
https://www.readbyqxmd.com/read/28919174/new-nih-regulations-say-most-basic-human-brain-research-is-a-clinical-trial
#6
Adina L Roskies
New NIH definitions classify virtually all human brain and behavioral research as clinical trials. The new definitions will change regulatory, reporting, and funding schemes for noninvasive studies such as neuroimaging. Resulting burdens threaten the viability of basic biobehavioral science research.
September 13, 2017: Neuron
https://www.readbyqxmd.com/read/28916234/regulatory-capture-and-financial-crisis-comment-on-modeling-human-behavior-in-economics-and-social-science-by-marina-dolfin-leone-leonida-and-nisrina-outada
#7
George Kapetanios, Eleonora Muzzupappa
No abstract text is available yet for this article.
September 8, 2017: Physics of Life Reviews
https://www.readbyqxmd.com/read/28915215/mechanisms-involved-in-secondary-cardiac-dysfunction-in-animal-models-of-trauma-and-hemorrhagic-shock
#8
Nick M Wilson, Johanna Wall, Veena Naganathar, Karim Brohi, Henry D De'Ath
Clinical evidence reveals the existence of a trauma-induced secondary cardiac injury (TISCI) that is associated with poor patient outcomes. The mechanisms leading to TISCI in injured patients are uncertain. Conversely, animal models of trauma hemorrhage have repeatedly demonstrated significant cardiac dysfunction following injury, and highlighted mechanisms through which this might occur. The aim of this review was to provide an overview of the animal studies describing TISCI and its pathophysiology.Basic science models of trauma show evidence of innate immune system activation via Toll-like receptors, the exact protagonists of which remain unclear...
October 2017: Shock
https://www.readbyqxmd.com/read/28911604/nanotechnology-in-food-science-functionality-applicability-and-safety-assessment
#9
REVIEW
Xiaojia He, Huey-Min Hwang
Rapid development of nanotechnology is expected to transform many areas of food science and food industry with increasing investment and market share. In this article, current applications of nanotechnology in food systems are briefly reviewed. Functionality and applicability of food-related nanotechnology are highlighted in order to provide a comprehensive view on the development and safety assessment of nanotechnology in the food industry. While food nanotechnology offers great potential benefits, there are emerging concerns arising from its novel physicochemical properties...
October 2016: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/28903896/the-regulatory-functions-of-pirna-piwi-in-spermatogenesis
#10
Zhi-Heng Yuan, Yan-Mei Zhao
A class of 24-32 nt PIWI-binding small noncoding RNAs (sncRNAs) termed as PIWI-interacting RNAs (piRNAs) have been identified in animal germline. Recent studies suggest that piRNA/PIWI pathway plays a critical role in both silencing of transposons and posttranscriptional regulation of mRNAs in animal germline. A study from Dr. Mofang Liu's lab in Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, reveals the physiological and pathological importance of PIWI metabolism (mouse PIWI as known as MIWI; human PIWI as HIWI) in mammalian spermatogenesis...
August 20, 2017: Yi Chuan, Hereditas
https://www.readbyqxmd.com/read/28903820/considerations-when-writing-and-reviewing-a-higher-education-teaching-protocol-involving-animals
#11
Tracy H Vemulapalli, Shawn S Donkin, Timothy B Lescun, Peggy A O'Neil, Patrick A Zollner
The targeted use of animals in teaching at institutions of higher learning is fundamental to educating the next generation of professionals in the biologic and animal sciences. As with animal research, universities and colleges that use animals in teaching are subject to regulatory oversight. Instructors must receive approval from their IACUC before using animals in their teaching. However, the questions asked on many institutions' animal care and use protocol (ACUP) are often geared more toward the use of animals for research...
September 1, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28898589/science-of-biosimilars
#12
R Donald Harvey
Biosimilar therapeutic proteins in oncology offer the potential to decrease costs while providing safety and efficacy profiles consistent with their respective reference or originator products. Biosimilars have a number of important differences from generic small-molecule drugs, including manufacturing processes that are unique from their reference products. These differences may affect biosimilars through posttranslational modifications that can occur in specific cellular production lines, and these modifications have potential effects on protein structure, function, clinical pharmacology, and immunogenicity...
September 2017: Journal of Oncology Practice
https://www.readbyqxmd.com/read/28888213/occurrence-fate-and-transformation-of-emerging-contaminants-in-water-an-overarching-review-of-the-field
#13
REVIEW
John Wilkinson, Peter S Hooda, James Barker, Stephen Barton, Julian Swinden
Many of the products and drugs used commonly contain chemical components which may persist through sewage treatment works (STW) and eventually enter the aquatic environment as parent compounds, metabolites, or transformation products. Pharmaceuticals and personal care products (PPCPs) and other emerging contaminants (ECs) have been detected in waters (typically ng/L) as well as more recently bound to sediment and plastic particles (typically ng/g). Despite significant advancement of knowledge since the late 1990s, the fate of these contaminants/transformation products once introduced into the aquatic environment remains relatively unresolved...
September 6, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28882904/frontline-science-proliferation-of-ly6c-monocytes-during-urinary-tract-infections-is-regulated-by-il-6-trans-signaling
#14
Akanksha Dixit, Jenny Bottek, Anna-Lena Beerlage, Jana Schuettpelz, Stephanie Thiebes, Alexandra Brenzel, Christoph Garbers, Stefan Rose-John, Hans-Willi Mittrücker, Anthony Squire, Daniel R Engel
Ly6C(+) monocytes are important components of the innate immune defense against infections. These cells have been shown to proliferate in the bone marrow of mice with systemic infections. However, the proliferative capacity of Ly6C(+) monocytes in infected peripheral tissues as well as the associated regulatory mechanisms remain unclear. In this study, we analyzed the proliferative capacity of Ly6C(+) monocytes in the urinary bladder after infection with uropathogenic E. coli, one of the most prevalent pathogen worldwide, and in LPS-induced peritonitis...
September 7, 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/28878023/maximal-aggregation-of-polynomial-dynamical-systems
#15
Luca Cardelli, Mirco Tribastone, Max Tschaikowski, Andrea Vandin
Ordinary differential equations (ODEs) with polynomial derivatives are a fundamental tool for understanding the dynamics of systems across many branches of science, but our ability to gain mechanistic insight and effectively conduct numerical evaluations is critically hindered when dealing with large models. Here we propose an aggregation technique that rests on two notions of equivalence relating ODE variables whenever they have the same solution (backward criterion) or if a self-consistent system can be written for describing the evolution of sums of variables in the same equivalence class (forward criterion)...
September 6, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28877430/non-target-screening-with-high-resolution-mass-spectrometry-in-the-environment-ready-to-go
#16
Juliane Hollender, Emma Louise Schymanski, Heinz Singer, P Lee Ferguson
The vast, diverse universe of organic pollutants is a formidable challenge for environmental sciences, engineering, and regulation. Non-target screening (NTS) based on high resolution mass spectrometry (HRMS) has enormous potential to help characterize this universe - but is it ready to go for real world applications? In this Feature article we argue that development of mass spectrometers with increasingly high resolution and novel couplings to both liquid and gas chromatography, combined with the integration of high performance computing, have significantly widened our analytical window and have enabled increasingly sophisticated data processing strategies, indicating a bright future for NTS...
September 6, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28876538/mikl%C3%A3-s-bodanszky-award-lecture-advances-in-the-selective-targeting-of-protein-phosphatase-1-and-phosphatase-2a-with-peptides
#17
REVIEW
Maja Köhn
Protein phosphatase-1 and phosphatase-2A are two ubiquitously expressed enzymes known to catalyze the majority of dephosphorylation reactions on serine and threonine inside cells. They play roles in most cellular processes and are tightly regulated by regulatory subunits in holoenzymes. Their misregulation and malfunction contribute to disease development and progression, such as in cancer, diabetes, viral infections, and neurological as well as heart diseases. Therefore, targeting these phosphatases for therapeutic use would be highly desirable; however, their complex regulation and high conservation of the active site have been major hurdles for selectively targeting them in the past...
October 2017: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://www.readbyqxmd.com/read/28876358/animal-models-in-biological-and-biomedical-research-experimental-and-ethical-concerns
#18
Monica L Andersen, Lucile M F Winter
Animal models have been used in experimental research to increase human knowledge and contribute to finding solutions to biological and biomedical questions. However, increased concern for the welfare of the animals used, and a growing awareness of the concept of animal rights, has brought a greater focus on the related ethical issues. In this review, we intend to give examples on how animals are used in the health research related to some major health problems in Brazil, as well as to stimulate discussion about the application of ethics in the use of animals in research and education, highlighting the role of National Council for the Control of Animal Experimentation (Conselho Nacional de Controle de Experimentação Animal - CONCEA) in these areas...
September 4, 2017: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/28875839/repositioning-drugs-for-rare-immune-diseases-hopes-and-challenges-for-a-precision-medicine
#19
Erica Valencic, Alenka Smid, Ziga Jakopin, Alberto Tommasini, Irena Mlinaric-Rascan
Human primary immunodeficiency diseases (PIDs) are a large group of rare diseases and are characterized by a great genetic and phenotypic heterogeneity. A large subset of PIDs is genetically defined, which has a crucial impact for the understanding of the molecular basis of disease and the development of precision medicine. Discovery and development of new therapies for rare diseases has long been de-privileged due to the length and cost of the processes involved. Interest has increased due to stimulatory regulatory and supportive reimbursement environments enabling viable business models...
August 29, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28873717/herbal-products-containing-hibiscus-sabdariffa-l-crataegus-spp-and-panax-spp-labeling-and-safety-concerns
#20
Maria Antónia Nunes, Francisca Rodrigues, Rita C Alves, Maria Beatriz P P Oliveira
Herbs have been used from ancient times for infusion preparation based on their potential health effects. In particular, the consumption of Hibiscus sabdariffa L., Crataegus spp. and Panax spp. has been largely associated to cardiovascular benefits. In this work, the label information of 52 herbal products for infusion preparation containing the referred herbs was analyzed and discussed, taking into consideration the European Union regulation for herbal products, which intends to protect public health and harmonize the legal framework in Member States...
October 2017: Food Research International
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