keyword
https://read.qxmd.com/read/38542375/chaperones-a-new-class-of-potential-therapeutic-targets-in-alzheimer-s-disease
#1
REVIEW
Joanna Batko, Katarzyna Antosz, Weronika Miśków, Magdalena Pszczołowska, Kamil Walczak, Jerzy Leszek
The review describes correlations between impaired functioning of chaperones and co-chaperones in Alzheimer's disease (AD) pathogenesis. The study aims to highlight significant lines of research in this field. Chaperones like Hsp90 or Hsp70 are critical agents in regulating cell homeostasis. Due to some conditions, like aging, their activity is damaged, resulting in β-amyloid and tau aggregation. This leads to the development of neurocognitive impairment. Dysregulation of co-chaperones is one of the causes of this condition...
March 17, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38492099/polymorphism-in-genes-encoding-adaptor-proteins-st13-and-stip1-and-the-risk-of-ischemic-stroke-a-pilot-study
#2
JOURNAL ARTICLE
T A Stetskaya, A B Krapiva, K A Kobzeva, D E Gurtovoy, G V Komkova, A V Polonikov, O Yu Bushueva
Adaptor proteins stress induced phosphoprotein 1 (STIP1) and ST13 Hsp70 interacting protein (ST13) may play a crucial role in the pathophysiology of ischemic stroke through controlling protein folding, neuronal survival, and regulation of HSP70/HSP90. The present pilot study investigated whether tagSNPs in genes encoding ST13 (rs138335, rs138344, rs7290793, and rs138344) and STIP1 (rs4980524) are associated with ischemic stroke. DNA samples from 721 ischemic stroke patients and 471 healthy controls were genotyped using the MassArray-4...
March 16, 2024: Bulletin of Experimental Biology and Medicine
https://read.qxmd.com/read/38471267/stub1-increases-adiponectin-expression-by-inducing-ubiquitination-and-degradation-of-nr2f2-thereby-reducing-hepatic-stellate-cell-activation-and-alleviating-non-alcoholic-fatty-liver-disease
#3
JOURNAL ARTICLE
Zheng Mao, Jindong Zhao, Fan Cui, Zhen Li, Jinjin Cao, Jingjing Zhou, Mingliang Hou, Zengkun Qian
BACKGROUND: Adiponectin (APN) has exhibited ameliorating effects on non-alcoholic fatty liver disease (NAFLD). This study investigates the roles of APN and its regulatory molecules in hepatic stellate cell (HSC) activation and the progression of NAFLD. METHODS: Mice were subjected to a high-fat diet (HFD) to establish NAFLD models. Liver tissue was examined for lipid metabolism, fibrosis, and inflammation. Mouse 3T3-L1 adipocytes were exposed to palmitic acid (PA) to mimic a high-fat environment...
March 2, 2024: Tissue & Cell
https://read.qxmd.com/read/38460155/phosphorylated-shmt2-regulates-oncogenesis-through-m-6-a-modification-in-lung-adenocarcinoma
#4
JOURNAL ARTICLE
Tianyu Han, Yanan Wang, Minzhang Cheng, Qifan Hu, Xiaorui Wan, Menglin Huang, Yuhan Liu, Wenze Xun, Jin Xu, Lei Wang, Ruiguang Luo, Yi Yuan, Keru Wang, Jianbin Wang
Targeting cancer-specific metabolic processes is a promising therapeutic strategy. Here, this work uses a compound library that directly inhibits metabolic enzymes to screen the potential metabolic targets in lung adenocarcinoma (LUAD). SHIN1, the specific inhibitor of serine hydroxymethyltransferase 1/2 (SHMT1/2), has a highly specific inhibitory effect on LUAD cells, and this effect depends mainly on the overexpression of SHMT2. This work clarifies that mitogen-activated protein kinase 1 (MAPK1)-mediated phosphorylation at Ser90 is the key mechanism underlying SHMT2 upregulation in LUAD and that this phosphorylation stabilizes SHMT2 by reducing STIP1 homology and U-box containing protein 1 (STUB1)-mediated ubiquitination and degradation...
March 9, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/38342844/a-chinese-family-with-digenic-tbp-stub1-spinocerebellar-ataxia
#5
JOURNAL ARTICLE
Lili Liu, Juanjuan Chen, Guogao Zhang, Zhijian Lin, Di Chen, Jun Hu
Spinocerebellar ataxias (SCAs) are inherited neurodegenerative diseases characterized by loss of balance, coordination, and slurred speech. Recently, a digenic mode of inheritance of TBP/STUB1 contributing to SCA was demonstrated. The clinical manifestations of SCATBP/STUB1 include not only ataxia but also obvious cognitive and behavioral impairment. Here, we describe a Chinese family with SCATBP/STUB1 and performed a literature search for similar cases. We identified a Chinese family with SCATBP/STUB1 and compare our clinical findings with other cases described in the literature so far...
February 12, 2024: Cerebellum
https://read.qxmd.com/read/38012811/an-aptamer-based-nanoflow-cytometry-method-for-the-molecular-detection-and-classification-of-ovarian-cancers-through-profiling-of-tumor-markers-on-small-extracellular-vesicles
#6
JOURNAL ARTICLE
Jin Li, Yingying Li, Qin Li, Lu Sun, Qingqing Tan, Liyan Zheng, Ye Lu, Jianqing Zhu, Fengli Qu, Weihong Tan
Molecular profiling of protein markers on small extracellular vesicles (sEVs) is a promising strategy for the precise detection and classification of ovarian cancers. However, this strategy is challenging owing to the lack of simple and practical detection methods. In this work, using an aptamer-based nanoflow cytometry (nFCM) detection strategy, a simple and rapid method for the molecular profiling of multiple protein markers on sEVs was developed. The protein markers can be easily labeled with aptamer probes and then rapidly profiled by nFCM...
November 27, 2023: Angewandte Chemie
https://read.qxmd.com/read/37950051/usf2-promotes-autophagy-and-proliferation-in-chronic-lymphocytic-leukemia-by-inhibiting-stub1-induced-nfat5-ubiquitination
#7
JOURNAL ARTICLE
Beili Chen, Yanyi Zhao, Shujuan Xu, Fang Jiang, Yuwei Nie, Ailin Tang, Qin Zhou
Chronic lymphocytic leukemia (CLL) mainly affects the health of older adults and is difficult to cure. Upstream stimulatory factor 2 (USF2) has been implicated in several diseases and conditions including cancers. However, the effect of USF2 on CLL has not been elucidated. To investigate the effect of USP2 on proliferation and autophagy of CLL, and to explore the underlying mechanism. The mRNA of USF2 and STIP1 homology and U-Box containing protein 1 (STUB1) was analyzed using qRT-PCR. Western blots were used to evaluate the expression level of USF2, LC3II, Beclin-1, P62, STUB1, and NFAT5...
November 10, 2023: Annals of Hematology
https://read.qxmd.com/read/37904692/the-potential-roles-of-stress-induced-phosphoprotein-1-and-connexin-43-in-rats-with-reperfusion-arrhythmia
#8
JOURNAL ARTICLE
Li An, Hong Gao, Yi Zhong, Yanqiu Liu, Ying Cao, Jing Yi, Xiang Huang, Chunlei Wen, Rui Tong, Zhijun Pan, Xu Yan, Meiyan Liu, Shengzhao Wang, Hao Wu, Tingju Hu
OBJECTIVE: Connexin 43 (Cx43) is a critical gene for maintaining myocardial homeostasis. Interestingly, Cx43 and stress-induced phosphoprotein 1 (STIP1) were recorded to be lowly expressed in ischemia/reperfusion (I/R). However, their impacts on reperfusion arrhythmia (RA) remain to be explored. Our study aimed to find out the related underlying mechanisms. METHODS: After the establishment of an isolated heart model through Langendorff perfusion, the heart rate, conduction activation time, conduction velocity, and conduction direction of the left ventricle were evaluated, along with the apoptotic rate detection in the collected myocardial tissues...
October 2023: Immunity, Inflammation and Disease
https://read.qxmd.com/read/37830762/elp2-nlrp3-gsdmd-gsdme-mediated-pyroptosis-is-induced-by-tnf-%C3%AE-in-mc3t3-e1-cells-during-osteogenic-differentiation
#9
JOURNAL ARTICLE
Changliang Xia, Shuanji Ou, Yang Yang, Wei Zhang, Wenjiao Wu, Qi Chen, Wenjun Li, Hanyu Lu, Yeyang Wang, Yong Qi, Changpeng Xu
Tumour necrosis factor-α (TNF-α) is a cytokine involved in systemic inflammation. TNF-α slows down osteogenic differentiation, which may contribute to poor bone development in the inflammatory microenvironment. TNF-α inhibits osteogenic differentiation by activating the JAK-STAT3 pathway, of which Signal transducer and activator of transcription 3 (STAT3)-interacting protein 1 (StIP1, also known as elongator complex protein 2, ELP2) is a key protein in the JAK-STAT3 pathway. We investigated whether and how ELP2 activation mediates the TNF-α-induced pyroptosis during osteoblastic differentiation...
October 13, 2023: Journal of Cellular and Molecular Medicine
https://read.qxmd.com/read/37806517/linc01226-promotes-gastric-cancer-progression-through-enhancing-cytoplasm-to-nucleus-translocation-of-stip1-and-stabilizing-%C3%AE-catenin-protein
#10
JOURNAL ARTICLE
Hui Hua, Tao Su, Linyu Han, Long Zhang, Yizhou Huang, Nasha Zhang, Ming Yang
Gastric cancer (GC) remains one of the most common malignances and the leading cause of cancer-related mortality worldwide. Although the critical role of several long non-coding RNAs (lncRNAs) transcribed from a small number of GC-risk loci has been established, we still know little about the biological significance of these lncRNAs at most gene loci and how they play in cell signaling. In the present study, we identified a novel GC oncogenic lncRNA LINC01226 transcribed from the 1p35.2 risk locus. LINC01226 shows markedly higher expression levels in GC specimens compared with those in normal tissues...
October 6, 2023: Cancer Letters
https://read.qxmd.com/read/37732200/causal-genetic-loci-for-a-motivated-behavior-spectrum-harbor-psychiatric-risk-genes
#11
Jiale Xu, Romelo Casanave, Apurva S Chitre, Qiyang Wang, Khai-Minh Nguyen, Chiara Blake, Mahendra Wagle, Riyan Cheng, Oksana Polesskaya, Abraham A Palmer, Su Guo
Behavioral diversity is critical for population fitness. Individual differences in risk-taking are observed across species, but underlying genetic mechanisms and conservation are largely unknown. We examined dark avoidance in larval zebrafish, a motivated behavior reflecting an approach-avoidance conflict. Brain-wide calcium imaging revealed significant neural activity differences between approach-inclined versus avoidance-inclined individuals. We used a population of ∼6,000 to perform the first genome-wide association study (GWAS) in zebrafish, which identified 34 genomic regions harboring many genes that are involved in synaptic transmission and human psychiatric diseases...
September 6, 2023: bioRxiv
https://read.qxmd.com/read/37717354/extremely-low-frequency-electromagnetic-field-induces-acetylation-of-heat-shock-proteins-and-enhances-protein-folding
#12
JOURNAL ARTICLE
Zhizhou Huang, Mikako Ito, Shaochuan Zhang, Takuro Toda, Jun-Ichi Takeda, Tomoo Ogi, Kinji Ohno
The pervasive weak electromagnetic fields (EMF) inundate the industrialized society, but the biological effects of EMF as weak as 10 µT have been scarcely analyzed. Heat shock proteins (HSPs) are molecular chaperones that mediate a sequential stress response. HSP70 and HSP90 provide cells under undesirable situations with either assisting covalent folding of proteins or degrading improperly folded proteins in an ATP-dependent manner. Here we examined the effect of extremely low-frequency (ELF)-EMF on AML12 and HEK293 cells...
September 15, 2023: Ecotoxicology and Environmental Safety
https://read.qxmd.com/read/37577231/roles-and-molecular-mechanisms-of-biomarkers-in-hepatocellular-carcinoma-with-microvascular-invasion-a-review
#13
REVIEW
Xudong Zhao, Yudan Wang, Haoming Xia, Shuqiang Liu, Ziyue Huang, Risheng He, Liang Yu, Nanfeng Meng, Hang Wang, Junqi You, Jinglin Li, Judy Wai Ping Yam, Yi Xu, Yunfu Cui
Hepatocellular carcinoma (HCC) being a leading cause of cancer-related death, has high associated mortality and recurrence rates. It has been of great necessity and urgency to find effective HCC diagnosis and treatment measures. Studies have shown that microvascular invasion (MVI) is an independent risk factor for poor prognosis after hepatectomy. The abnormal expression of biomacromolecules such as circ-RNAs, lncRNAs, STIP1, and PD-L1 in HCC patients is strongly correlated with MVI. Deregulation of several markers mentioned in this review affects the proliferation, invasion, metastasis, EMT, and anti-apoptotic processes of HCC cells through multiple complex mechanisms...
October 28, 2023: Journal of Clinical and Translational Hepatology
https://read.qxmd.com/read/37515378/hsp90%C3%AE-impedes-stub1-induced-ubiquitination-of-ythdf2-to-drive-sorafenib-resistance-in-hepatocellular-carcinoma
#14
JOURNAL ARTICLE
Yuning Liao, Yuan Liu, Cuifu Yu, Qiucheng Lei, Ji Cheng, Weiyao Kong, Yuanhui Yu, Xuefen Zhuang, Wenshuang Sun, Shusha Yin, Gengxi Cai, Hongbiao Huang
YTH domain family 2 (YTHDF2) is the first identified N6-methyladenosine (m6 A) reader that regulates the status of mRNA. It has been reported that overexpressed YTHDF2 promotes carcinogenesis; yet, its role in hepatocellular carcinoma (HCC) is elusive. Herein, it is demonstrated that YTHDF2 is upregulated and can predict poor outcomes in HCC. Decreased ubiquitination levels of YTHDF2 contribute to the upregulation of YTHDF2. Furthermore, heat shock protein 90 beta (HSP90β) and STIP1 homology and U-box-containing protein 1 (STUB1) physically interact with YTHDF2 in the cytoplasm...
July 28, 2023: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/37506582/stub1-chip-new-insights-in-cancer-and-immunity
#15
REVIEW
Yongshuo Liu, Honghong Zhou, Xiaolong Tang
The STUB1 gene (STIP1 homology and U-box-containing protein 1), located at 16q13.3, encodes the CHIP (carboxyl terminus of Hsc70-interacting protein), an essential E3 ligase involved in protein quality control. CHIP comprises three domains: an N-terminal tetratricopeptide repeat (TPR) domain, a middle coiled-coil domain, and a C-terminal U-box domain. It functions as a co-chaperone for heat shock protein (HSP) via the TPR domain and as an E3 ligase, ubiquitinating substrates through its U-box domain. Numerous studies suggest that STUB1 plays a crucial role in various physiological process, such as aging, autophagy, and bone remodeling...
July 26, 2023: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/37488801/-stip1-correlates-with-tumor-immune-infiltration-and-prognosis-as-a-potential-immunotherapy-target-a-pan-cancer-bioinformatics-analysis
#16
JOURNAL ARTICLE
S Guan, Z Shen, M Lin, H Deng, Y Fang
OBJECTIVE: To investigate the correlation of stress-inducible phosphoprotein 1 (STIP1) expression level with prognosis of different cancers and its potential role in immunotherapy. METHODS: TCGA, TARGET and GTEx databases were used for bioinformatic analysis of STIP1 expression level and its prognostic value in different cancers. We also detected STIP1 expression immunohistochemically in 10 pairs of colorectal cancer and adjacent tissues. We further analyzed the correlation of STIP1 expression level with tumor mutational burden, microsatellite instability, immune cell infiltration, immune regulators and outcomes of different cancers...
July 20, 2023: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://read.qxmd.com/read/37442266/tumor-promoting-action-of-ubiquitin-protease-43-in-gastric-cancer-progression-through-deubiquitination-and-stabilization-of-stress-inducible-phosphoprotein-1
#17
JOURNAL ARTICLE
Zijun Guo, Lin Guo
Gastric cancer (GC) is the 5th most common cancer over the world. Ubiquitin protease 43 (UBP43) is a multifunctional protein with deubiquitinase activities. Abnormal expression of UBP43 has been reported in numerous types of malignancies. Bioinformatic analysis was performed to identify the differentially expressed genes (Fold change ≥2 or ≤ -2 and p < 0.01) in GC from the datasets downloaded from Gene Expression Omnibus and Gene Expression Profiling Interactive Analysis databases, which showed that UBP43 and stress-inducible phosphoprotein 1 (STIP1) were up-regulated in both datasets...
July 11, 2023: Experimental Cell Research
https://read.qxmd.com/read/37416474/stub1-mediated-ubiquitination-regulates-the-stability-of-glud1-in-lung-adenocarcinoma
#18
JOURNAL ARTICLE
Qifan Hu, Jiapeng Lei, Zhujun Cheng, Jing Xu, Lei Wang, Yi Yuan, Mingxi Gan, Yanan Wang, Yilin Xie, Lu Yao, Keru Wang, Yuhan Liu, Wenze Xun, Jian-Bin Wang, Tianyu Han
The dysregulation of glutamine metabolism provides survival advantages for tumors by supplementing tricarboxylic acid cycle. Glutamate dehydrogenase 1 (GLUD1) is one of the key enzymes in glutamine catabolism. Here, we found that enhanced protein stability was the key factor for the upregulation of GLUD1 in lung adenocarcinoma. We discovered that GLUD1 showed a high protein expression in lung adenocarcinoma cells or tissues. We elucidated that STIP1 homology and U-box-containing protein 1 (STUB1) was the key E3 ligase responsible for ubiquitin-mediated proteasomal degradation of GLUD1...
July 21, 2023: IScience
https://read.qxmd.com/read/37187948/molecular-chaperones-hsp40-hsp70-stip1-and-hsp90-are-involved-in-stabilization-of-cx43
#19
JOURNAL ARTICLE
Li An, Hong Gao, Yi Zhong, Yanqiu Liu, Ying Cao, Jing Yi, Xiang Huang, Chunlei Wen, Rui Tong, Zhijun Pan, Xu Yan, Meiyan Liu, Shengzhao Wang, Xue Bai, Hao Wu, Tingju Hu
To investigate the involvement of stress induced phosphoprotein 1 (STIP1), heat shock protein (HSP) 70, and HSP90 in ubiquitination of connexin 43 (Cx43) in rat H9c2 cardiomyocytes. Co-immunoprecipitation was used to detect protein-protein interactions and Cx43 ubiquitination. Immunofluorescence was used for protein co-localization. The protein binding, Cx43 protein expression, and Cx43 ubiquitination were reanalyzed in H9c2 cells with modified STIP1 and/or HSP90 expression. STIP1 bound to HSP70 and HSP90, and Cx43 bound to HSP40, HSP70, and HSP90 in normal H9c2 cardiomyocytes...
June 2023: Cytotechnology
https://read.qxmd.com/read/37182691/elucidating-cellular-interactome-of-chikungunya-virus-identifies-host-dependency-factors
#20
JOURNAL ARTICLE
Peiqi Yin, Xia Jian, Yihan Liu, Yuwen Liu, Lu Lv, Haoran Cui, Leiliang Zhang
Chikungunya virus (CHIKV) is a re-emerging mosquito-transmitted RNA virus causing joint and muscle pain. To better understand how CHIKV rewires the host cell and usurps host cell functions, we generated a systematic CHIKV-human protein-protein interaction map and revealed several novel connections that will inform further mechanistic studies. One of these novel interactions, between the viral protein E1 and STIP1 homology and U-box containing protein 1 (STUB1), was found to mediate ubiquitination of E1 and degrade E1 through the proteasome...
May 12, 2023: Virologica Sinica
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