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STIP1

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https://www.readbyqxmd.com/read/29596884/stip1-is-over-expressed-in-hepatocellular-carcinoma-and-promotes-the-growth-and-migration-of-cancer-cells
#1
Xiaoling Luo, Yuting Liu, Shijie Ma, Lei Liu, Rui Xie, Miaomiao Li, Peng Shen, Shaochuang Wang
Wnt/beta-catenin signaling is frequently activated in hepatocellular carcinoma (HCC). Better understanding the mechanism for its over-activation would help the therapy. In this study, we have shown that the stress-induced phosphoprotein 1 (STIP1) is up-regulated in the HCC tissues. Functional studies showed that STIP1 promoted the growth, colony formation and migration of cancer cells. However, knocking down the expression of STIP1 inhibited the growth, colony formation and migration of cancer cells. Molecular mechanism study showed that STIP1 interacted with Axin, enhanced the interaction between Axin and DVL2, thus activated beta-catenin/TCF signaling...
March 26, 2018: Gene
https://www.readbyqxmd.com/read/29593255/stress-induced-phosphoprotein-1-acts-as-a-scaffold-protein-for-glycogen-synthase-kinase-3-beta-mediated-phosphorylation-of-lysine-specific-demethylase-1
#2
Chia-Lung Tsai, An-Shine Chao, Shih-Ming Jung, Chiao-Yun Lin, Angel Chao, Tzu-Hao Wang
Stress-induced phosphoprotein 1 (STIP1)-a co-chaperone of heat shock proteins-promotes cell proliferation and may act as an oncogenic factor. Similarly, glycogen synthase kinase-3 beta (GSK3β)-mediated phosphorylation of lysine-specific demethylase 1 (LSD1)-an epigenetic regulator-can contribute to the development of an aggressive cell phenotype. Owing to their ability to tether different molecules into functional complexes, scaffold proteins have a key role in the regulation of different signaling pathways in tumorigenesis...
March 29, 2018: Oncogenesis
https://www.readbyqxmd.com/read/29578315/genes-involved-in-stress-response-influence-lithium-efficacy-in-bipolar-patients
#3
Aleksandra Szczepankiewicz, Beata Narozna, Janusz K Rybakowski, Sebastian Kliwicki, Piotr Czerski, Monika Dmitrzak-Węglarz, Maria Skibińska, Joanna Twarowska-Hauser, Joanna Pawlak
OBJECTIVES: In mood disorders, chronic stimulation with stress results in aberrant regulation of the hypothalamic-pituitary-adrenal (HPA) axis. Lithium was shown to influence HPA axis function. The underlying genetic background as well as environmental context may influence the stress response, and therefore lithium efficacy. The aim of the present study was to analyze if genetic variants located in genes involved in HPA axis regulation affect the response to long-term lithium treatment in bipolar patients...
March 26, 2018: Bipolar Disorders
https://www.readbyqxmd.com/read/29559743/stress-induced-phosphoprotein-1-mediates-hepatocellular-carcinoma-metastasis-after-insufficient-radiofrequency-ablation
#4
Tianhong Su, Junbin Liao, Zihao Dai, Lixia Xu, Shuling Chen, Yifei Wang, Zhenwei Peng, Qiuyang Zhang, Sui Peng, Ming Kuang
Recent studies indicated that insufficient radiofrequency ablation (RFA) could endow hepatocellular carcinoma (HCC) with higher aggressive potential. Stress-induced phosphoprotein 1 (STIP1), which was found highly expressed in HCC, is a chaperone molecule mediating cell homeostasis under thermal stress. We aimed to explore the role of STIP1 on the metastasis of residual HCC after RFA. Mice model with orthotopic HCC implants or caudal vein injection were employed to assess potential of lung metastasis and/or intrahepatic metastasis (IHM) of HCC cells...
March 21, 2018: Oncogene
https://www.readbyqxmd.com/read/29411462/delayed-gastric-emptying-and-altered-antrum-protein-metabolism-during-activity-based-anorexia
#5
S Nobis, A Morin, N Achamrah, L Belmonte, R Legrand, P Chan, J-L do Rego, D Vaudry, G Gourcerol, P Déchelotte, A Goichon, M Coëffier
BACKGROUND: Anorexia nervosa, a restrictive eating disorder, is often associated with gastrointestinal disorders, particularly a delayed gastric emptying. However, the mechanisms remained poorly documented. Thus, we aimed to evaluate gastric emptying and antrum protein metabolism in the Activity-Based Anorexia model (ABA). METHODS: Females C57Bl/6 mice were randomized into 3 groups: Control, ABA, and Limited Food Access (LFA). Food access has been progressively limited from 6 h/day at day 6 to 3 h/day at day 9 and until day 17...
February 6, 2018: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/29335007/stress-inducible-protein-1-promotes-metastasis-of-gastric-cancer-via-wnt-%C3%AE-catenin-signaling-pathway
#6
Linlin Huang, Ertao Zhai, Shirong Cai, Yi Lin, Junbin Liao, Huilin Jin, Sui Peng, Lixia Xu, Minhu Chen, Zhirong Zeng
BACKGROUND: Stress-Inducible Protein-1 (STIP1) is a co-chaperone that associates directly with heat shock proteins, and regulates motility of various types of cancer. In the present study, we investigated the role of STIP1 on metastasis of gastric cancer (GC). METHODS: In vivo metastatic experimental model was employed to investigate the effect of STIP1 on metastasis of GC cells. Loss-of-function and gain-of-function experiments were performed to examine the role of STIP1 on metastasis of GC cells...
January 15, 2018: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/29304094/positive-associations-between-upregulated-levels-of-stress-induced-phosphoprotein-1-and-matrix-metalloproteinase-9-in-endometriosis-adenomyosis
#7
Hsin-Shih Wang, Chia-Lung Tsai, Pi-Yueh Chang, Angel Chao, Ren-Chin Wu, Shun-Hua Chen, Chin-Jung Wang, Chih-Feng Yen, Yun-Shien Lee, Tzu-Hao Wang
Stress-induced phosphoprotein-1 (STIP1), an adaptor protein that coordinates the functions of HSP70 and HSP90 in protein folding, has been implicated in the development of human gynecologic malignancies. This case-control study investigates STIP1 serum levels and tissue expression in relation to endometriosis/adenomyosis in Taiwanese population. Female patients with surgically confirmed endometriosis/adenomyosis were compared with women free of endometriosis/adenomyosis. Serum STIP1 levels were measured using an enzyme-linked immunosorbent assay and surgical tissues were analyzed by immunohistochemistry...
2018: PloS One
https://www.readbyqxmd.com/read/29251255/effects-of-genetic-factors-to-inhaled-corticosteroid-response-in-children-with-asthma-a-literature-review
#8
Huong Duong-Thi-Ly, Ha Nguyen-Thi-Thu, Long Nguyen-Hoang, Hanh Nguyen-Thi-Bich, Timothy J Craig, Sy Duong-Quy
Numerous studies have examined the association between pharmacogenetic effects and the response to inhaled corticosteroids (ICS) in patients with asthma. In fact, several single nucleotide polymorphisms of a number of candidate genes have been identified that might influence the clinical response to ICS in children with asthma. Their direct or indirect effects depend on their role in the inflammatory process in asthma or the anti-inflammatory action of corticosteroids, respectively. Among the genes identified, variants in T-box 21 ( TBX21) and Fc fragment of IgE receptor II ( FCER2) contribute indirectly to the variability in the response to ICS by altering the inflammatory mechanisms in asthma, while other genes such as corticotropin releasing hormone receptor 1 ( CRHR1), nuclear receptor subfamily 3 group C member 1 ( NR3C1), stress induced phosphoprotein 1 ( STIP1), dual specificity phosphatase 1 (DUSP1), glucocorticoid induced 1 (GLCCI1), histone deacetylase 1 (HDAC), ORMDL sphingolipid biosynthesis regulator 3 (ORMDL3), and vascular endothelial growth factors (VEGF) directly affect this variability through the anti-inflammatory mechanisms of ICS...
December 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/29167396/targeting-stub1-tissue-factor-axis-normalizes-hyperthrombotic-uremic-phenotype-without-increasing-bleeding-risk
#9
Moshe Shashar, Mostafa E Belghasem, Shinobu Matsuura, Joshua Walker, Sean Richards, Faisal Alousi, Keshab Rijal, Vijaya B Kolachalama, Mercedes Balcells, Minami Odagi, Kazuo Nagasawa, Joel M Henderson, Amitabh Gautam, Richard Rushmore, Jean Francis, Daniel Kirchhofer, Kumaran Kolandaivelu, David H Sherr, Elazer R Edelman, Katya Ravid, Vipul C Chitalia
Chronic kidney disease (CKD/uremia) remains vexing because it increases the risk of atherothrombosis and is also associated with bleeding complications on standard antithrombotic/antiplatelet therapies. Although the associations of indolic uremic solutes and vascular wall proteins [such as tissue factor (TF) and aryl hydrocarbon receptor (AHR)] are being defined, the specific mechanisms that drive the thrombotic and bleeding risks are not fully understood. We now present an indolic solute-specific animal model, which focuses on solute-protein interactions and shows that indolic solutes mediate the hyperthrombotic phenotype across all CKD stages in an AHR- and TF-dependent manner...
November 22, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28887036/autocrine-stip1-signaling-promotes-tumor-growth-and-is-associated-with-disease-outcome-in-hepatocellular-carcinoma
#10
Zebin Chen, Lixia Xu, Tianhong Su, Zunfu Ke, Zhenwei Peng, Ning Zhang, Sui Peng, Qiuyang Zhang, Gengxun Liu, Guangyan Wei, Yu Guo, Minghui He, Ming Kuang
Stress-induced phosphoprotein 1 (STIP1) is an adaptor protein that bridges between HSP70 and HSP90 folding and a secretory protein which regulates malignant cell growth. However, the role of STIP1 in hepatocellular carcinoma (HCC) remains unknown. Here, we found high expression of STIP1 in tumors was associated with worse overall survival (41.3 vs 62.7 months, P < 0.001) in 231 HCC patients. STIP1 was overexpressed in HCC tissues compared to adjacent non-tumor liver tissue (64.9% vs 4.0% P < 0.001), and serum STIP1 levels of HCC patients were elevated compared to healthy controls (P < 0...
November 4, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28852266/serum-autoantibodies-against-stip1-as-a-potential-biomarker-in-the-diagnosis-of-esophageal-squamous-cell-carcinoma
#11
Yi-Wei Xu, Can-Tong Liu, Xin-Yi Huang, Li-Sheng Huang, Yu-Hao Luo, Chao-Qun Hong, Hai-Peng Guo, Li-Yan Xu, Yu-Hui Peng, En-Min Li
Esophageal squamous cell carcinoma (ESCC) remains one of the leading causes of cancer-related mortality around the world. The identification of novel serum biomarkers is required for early detection of ESCC. This study was designed to elucidate whether autoantibodies against STIP1 could be a diagnostic biomarker in ESCC. An enzyme-linked immunosorbent assay was performed to detect serum levels of STIP1 autoantibodies in a training cohort (148 ESCC patients and 111 controls) and a validation cohort (60 ESCC patients and 40 controls)...
2017: Disease Markers
https://www.readbyqxmd.com/read/28820892/maternal-autoimmune-antibodies-alter-the-dendritic-arbor-and-spine-numbers-in-the-infragranular-layers-of-the-cortex
#12
Jeanelle Ariza, Jesus Hurtado, Haille Rogers, Raymond Ikeda, Michael Dill, Craig Steward, Donnay Creary, Judy Van de Water, Verónica Martínez-Cerdeño
An association between maternal IgG antibodies reactive against proteins in fetal brain and an outcome of autism in the child has been identified. Using a mouse model of prenatal intraventricular administration of autism-specific maternal IgG, we demonstrated that these antibodies produce behavioral alterations similar to those in children with ASD. We previously demonstrated that these antibodies bind to radial glial stem cells (RG) and observed an increase in the number of divisions of translocating RG in the developing cortex...
2017: PloS One
https://www.readbyqxmd.com/read/28819010/new-insight-on-the-s100a1-stip1-complex-highlights-the-important-relationship-between-allostery-and-entropy-in-protein-function
#13
REVIEW
Nathaniel V Nucci
Calcium signaling serves as a nexus of many vital cellular processes. Of particular importance is the role the calcium signaling plays in the prevention of protein misfolding, and the S100 family of calcium-binding proteins is a key player in this pathway. While the S100 proteins carry out a range of roles, the interaction of S100A1 and the stress-inducible phosphoprotein 1 (STIP1) has been shown to be particularly important. A recent study by Maciejewski et al. in Biochemical Journal ( Biochemical Journal (2017) 474 , 1853-1866) revealed new insights into the nature of the S100A1-STIP1 interaction...
August 17, 2017: Biochemical Journal
https://www.readbyqxmd.com/read/28719655/protein-analysis-and-gene-expression-indicate-differential-vulnerability-of-iberian-fish-species-under-a-climate-change-scenario
#14
Tiago F Jesus, João M Moreno, Tiago Repolho, Alekos Athanasiadis, Rui Rosa, Vera M F Almeida-Val, Maria M Coelho
Current knowledge on the biological responses of freshwater fish under projected scenarios of climate change remains limited. Here, we examine differences in the protein configuration of two endemic Iberian freshwater fish species, Squalius carolitertii and the critically endangered S. torgalensis that inhabit in the Atlantic-type northern and in the Mediterranean-type southwestern regions, respectively. We performed protein structure modeling of fourteen genes linked to protein folding, energy metabolism, circadian rhythms and immune responses...
2017: PloS One
https://www.readbyqxmd.com/read/28613983/azithromycin-attenuates-myofibroblast-differentiation-and-lung-fibrosis-development-through-proteasomal-degradation-of-nox4
#15
Kazuya Tsubouchi, Jun Araya, Shunsuke Minagawa, Hiromichi Hara, Akihiro Ichikawa, Nayuta Saito, Tsukasa Kadota, Nahoko Sato, Masahiro Yoshida, Yusuke Kurita, Kenji Kobayashi, Saburo Ito, Yu Fujita, Hirofumi Utsumi, Haruhiko Yanagisawa, Mitsuo Hashimoto, Hiroshi Wakui, Yutaka Yoshii, Takeo Ishikawa, Takanori Numata, Yumi Kaneko, Hisatoshi Asano, Makoto Yamashita, Makoto Odaka, Toshiaki Morikawa, Katsutoshi Nakayama, Yoichi Nakanishi, Kazuyoshi Kuwano
Accumulation of profibrotic myofibroblasts is involved in the process of fibrosis development during idiopathic pulmonary fibrosis (IPF) pathogenesis. TGFB (transforming growth factor β) is one of the major profibrotic cytokines for myofibroblast differentiation and NOX4 (NADPH oxidase 4) has an essential role in TGFB-mediated cell signaling. Azithromycin (AZM), a second-generation antibacterial macrolide, has a pleiotropic effect on cellular processes including proteostasis. Hence, we hypothesized that AZM may regulate NOX4 levels by modulating proteostasis machineries, resulting in inhibition of TGFB-associated lung fibrosis development...
August 3, 2017: Autophagy
https://www.readbyqxmd.com/read/28408431/molecular-basis-for-the-interaction-between-stress-inducible-phosphoprotein-1-stip1-and-s100a1
#16
COMPARATIVE STUDY
Andrzej Maciejewski, Vania F Prado, Marco A M Prado, Wing-Yiu Choy
Stress-inducible phosphoprotein 1 (STIP1) is a cellular co-chaperone, which regulates heat-shock protein 70 (Hsp70) and Hsp90 activity during client protein folding. Members of the S100 family of dimeric calcium-binding proteins have been found to inhibit Hsp association with STIP1 through binding of STIP1 tetratricopeptide repeat (TPR) domains, possibly regulating the chaperone cycle. Here, we investigated the molecular basis of S100A1 binding to STIP1. We show that three S100A1 dimers associate with one molecule of STIP1 in a calcium-dependent manner...
May 16, 2017: Biochemical Journal
https://www.readbyqxmd.com/read/28199984/autocrine-and-paracrine-stip1-signaling-promote-osteolytic-bone-metastasis-in-renal-cell-carcinoma
#17
Jiang Wang, Hongbo You, Jun Qi, Caihong Yang, Ye Ren, Hao Cheng
Bone metastases are responsible for some of the most devastating complications of renal cell carcinoma (RCC). However, pro-metastatic factors leading to the highly osteolytic characteristics of RCC bone metastasis have barely been explored. We previously developed novel bone-seeking RCC cell lines by the in vivo selection strategy and performed a comparative proteome analysis on their total cell lysate. Here, we focused on STIP1 (stress-induced phosphoprotein 1), the high up-regulated protein in the bone-seeking cells, and explored its clinical relevance and functions in RCC bone metastasis...
March 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28186972/recurrent-fusion-transcripts-in-squamous-cell-carcinomas-of-the-vulva
#18
Marta Brunetti, Antonio Agostini, Ben Davidson, Claes G Tropé, Sverre Heim, Ioannis Panagopoulos, Francesca Micci
Juxtaposition of two different genes or gene parts due to chromosomal rearrangement is a well-known neoplasia-associated pathogenetic mechanism. The detection and characterization of such tumorigenic fusions is of great importance both research-wise, diagnostically because they may be specific for distinct tumor entities, and because they may serve as therapeutic targets for antioncogenic drugs that interact directly with the molecular changes responsible for neoplastic transformation.At present, more than 10,000 fusion transcripts have been reported in different types of neoplasia, with one tenth of them being identified in squamous cell carcinomas (SCC) of different locations...
March 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/27681499/highly-sensitive-protein-detection-based-on-smart-hybrid-nanocomposite-controlled-switch-of-dna-polymerase-activity
#19
Yue Huang, Hao Li, Lei Wang, Xiaoxia Mao, Genxi Li
In this work, we have successfully designed a smart and flexible signal amplification method based on a newly synthesized hybrid nanocomposite with switchable enzyme activity for specific and sensitive protein detection. The smart hybrid nanocomposite synthesized here is initially loaded with quenched fluorophore and a unique aptamer-inhibited DNA polymerase. It then undergoes target protein-triggered release of the fluorophore and activation of the DNA polymerase, which can thereby promote multiple catalytic reactions and recycled use of the target protein, resulting in the generation of highly amplified signals...
October 4, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27409672/stress-induced-phosphoprotein-1-maintains-the-stability-of-jak2-in-cancer-cells
#20
Chia-Lung Tsai, Angel Chao, Shih-Ming Jung, Chi-Neu Tsai, Chiao-Yun Lin, Shun-Hua Chen, Shih-Che Sue, Tzu-Hao Wang, Hsin-Shih Wang, Chyong-Huey Lai
Overexpression of stress-induced phosphoprotein 1 (STIP1) - a co-chaperone of heat shock protein (HSP) 70/HSP90 - and activation of the JAK2-STAT3 pathway occur in several tumors. Combined treatment with a HSP90 inhibitor and a JAK2 inhibitor exert synergistic anti-cancer effects. Here, we show that STIP1 stabilizes JAK2 protein in ovarian and endometrial cancer cells. Knock-down of endogenous STIP1 decreased JAK2 and phospho-STAT3 protein levels. The N-terminal fragment of STIP1 interacts with the N-terminus of JAK2, whereas the C-terminal DP2 domain of STIP1 mediates the interaction with HSP90 and STAT3...
August 2, 2016: Oncotarget
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