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https://www.readbyqxmd.com/read/29234355/treatment-of-community-acquired-pneumonia-are-all-countries-treating-children-in-the-same-way-a-literature-review
#1
REVIEW
Daniele Donà, Dora Luise, Liviana Da Dalt, Carlo Giaquinto
Background: Pneumonia represents an important threat to children's health in both developed and developing countries. In the last 10 years, many national and international guidelines on the treatment of pediatric CAP have been published, in order to optimize the prescription of antibiotics and limit their cost and side effects. However, the practical implementation of these guidelines is still limited. Main Text: We analyzed the current recommendations for the therapy of pediatric community-acquired pneumonia (CAP) that all converge on the identification of aminopenicillins and beta-lactams as the optimal treatment for CAP...
2017: International Journal of Pediatrics
https://www.readbyqxmd.com/read/29232664/vaccination-practices-in-pediatric-dialysis-patients-across-europe-a-european-pediatric-dialysis-working-group-and-european-society-for-pediatric-nephrology-dialysis-working-group-study
#2
Sevcan A Bakkaloğlu, Yesim Özdemir Atikel, Fabio Paglialonga, Constantinos J Stefanidis, Varvara Askiti, Enrico Vidal, Gema Ariceta, Engin Melek, Enrico Verrina, Nikoleta Printza, Karel Vondrak, Aleksandra Zurowska, Ilona Zagozdzon, Mesiha Ekim, Elif Nursel Özmert, Stephanie Dufek, Augustina Jankauskiene, Claus Peter Schmitt, Eszter Lévai, Johan Vande Walle, Nur Canpolat, Tuula Holtta, Michel Fischbach, Guenter Klaus, Christoph Aufricht, Rukshana Shroff, Alberto Edefonti
BACKGROUND: Data on the immunization practices in pediatric chronic kidney disease (CKD) patients are scarce. The purpose of this study was to evaluate current vaccination practices for children on dialysis across European pediatric nephrology centers. METHODS: A total of 18 tertiary pediatric nephrology centers from 12 European countries were included in the study. The data on universal national immunization programs and immunization practices for children with chronic disease or risk were recorded from European Center for Disease Prevention and Control and the World Health Organization...
December 12, 2017: Nephron
https://www.readbyqxmd.com/read/29227466/morbidity-and-mortality-of-a-cohort-of-peruvian-hiv-infected-children-2003-2012
#3
Amira N Baker, Angela M Bayer, Rolando M Viani, Lenka Kolevic, Myung-Shin Sim, Jaime G Deville
BACKGROUND: Data on pediatric HIV in Peru is limited. The National Institute of Child Health (Instituto Nacional de Salud del Niño: INSN) cares for the most HIV-infected children under age 18 in the country. We describe the outcomes of children seen at INSN's HIV clinic over the 10 years when antiretroviral therapy (ART) and prevention of mother-to-child transmission (PMTCT) interventions became available in 2004. METHODS: We conducted a retrospective review of INSN HIV clinic patients between 2003-2012...
December 8, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29227265/-peculiarities-of-the-analysis-of-the-level-of-proinflammatory-cytokins-in-the-community-acquired-pneumonia-in-children
#4
A Akhaeyva, D Zhupenova, T Kenzhetaeva, A Kysabekova, S Dzhabaeva
The high specific gravity in the structure of morbidity in children of all age groups, complicated course, determines the urgency of studying the clinical and diagnostic aspects of community-acquired pneumonia. In recent years, interest has been growing in the study of the child's cytokine status. A number of studies indicate that cytokines regulate the severity and duration of the inflammatory process. In this regard, the study of the possibility of determining the level of proinflammatory cytokines (IL-6 , TNF-α) is of great practical importance for assessing the prognosis of community-acquired pneumonia in children...
November 2017: Georgian Medical News
https://www.readbyqxmd.com/read/29217961/clinical-profile-and-outcome-of-pediatrics-tetanus-the-experience-of-a-tertiary-hospital-in-ethiopia
#5
Henok Tadele
Background: Tetanus is an acute vaccine preventable illness manifested by neuromuscular dysfunction due to a potent exotoxin, tetanospasmin produced by Clostridium tetani. It is a common health problem in developing countries like Ethiopia. The aim of this study was to assess clinical profile and outcome of Pediatrics tetanus in a referral hospital, South Ethiopia. Methods: This is a retrospective cross-sectional study of medical records of 24 Pediatric tetanus patients who were admitted from July 2014 to June 2016 to the Pediatrics Department of Hawassa University Comprehensive Specialized Hospital, Hawassa-Ethiopia...
September 2017: Ethiopian Journal of Health Sciences
https://www.readbyqxmd.com/read/29217880/renal-manifestation-in-scrub-typhus-during-a-major-outbreak-in-central-nepal
#6
A Sedhain, G R Bhattarai
Renal involvement and acute kidney injury (AKI) are common clinical manifestations seen in scrub typhus, a vector-borne tropical disease. There are no data on renal manifestation in scrub typhus in Nepal. We conducted a prospective study to analyze the incidence, urinary abnormalities, course, severity, outcome, and the predictors of AKI in patients with scrub typhus during a major outbreak in Central Nepal. Total 1398 patients admitted with acute febrile illness were subjected for Scrub Typhus Detect™ Immunoglobulin M (IgM) enzyme-linked immunosorbent assay (ELISA) test, of which 502 (35...
November 2017: Indian Journal of Nephrology
https://www.readbyqxmd.com/read/29214503/epidemiology-and-clinical-characteristics-of-human-coronaviruses-oc43-229e-nl63-and-hku1-a-study-of-hospitalized-children-with-acute-respiratory-tract-infection-in-guangzhou-china
#7
Zhi-Qi Zeng, De-Hui Chen, Wei-Ping Tan, Shu-Yan Qiu, Duo Xu, Huan-Xi Liang, Mei-Xin Chen, Xiao Li, Zheng-Shi Lin, Wen-Kuan Liu, Rong Zhou
Human coronaviruses (HCoV) OC43, 229E, NL63, and HKU1 are common respiratory viruses which cause various respiratory diseases, including pneumonia. There is a paucity of evidence on the epidemiology and clinical manifestations of these four HCoV strains worldwide. We collected 11,399 throat swabs from hospitalized children with acute respiratory tract infection from July 2009 to June 2016 in Guangzhou, China. These were tested for four strains of HCoV infection using real-time polymerase chain reaction (PCR)...
December 6, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29210350/rotavirus-vaccine-will-improve-child-survival-by-more-than-just-preventing-diarrhea-evidence-from-bangladesh
#8
Senjuti Saha, Mathuram Santosham, Manzoor Hussain, Robert E Black, Samir K Saha
Despite the high burden of rotavirus diarrhea, uptake of rotavirus vaccines in Asia remains low. This primarily stems from a perception of rotavirus as a non-life-threatening pathogen amidst a background of competing health priorities and limited resources. In the largest pediatric hospital of Bangladesh, where there is a fierce competition for beds, we found that between November 2015 and October 2016, 12% of 23,064 admissions were due to gastrointestinal infections, 54% of which were caused by rotavirus. One in four cases requiring hospitalization, or 5,879 cases, was refused because of unavailability of beds...
December 4, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29206750/ceftazidime-avibactam-antimicrobial-activity-and-spectrum-when-tested-against-gram-negative-organisms-from-pediatric-patients-results-from-the-inform-surveillance-program-united-states-2011-2015
#9
Helio S Sader, Michael D Huband, Leonard R Duncan, Robert K Flamm
BACKGROUND: Ceftazidime-avibactam was approved by the US Food and Drug Administration in 2015 to treat complicated intra-abdominal and urinary tract infections in adults, and is under clinical development for treating pediatric patients. METHODS: Among 53,381 gram-negative organisms (1 per patient) collected in 2011-2015, 8,461 (15.9%) were from pediatric (≤17 years-old [yo]) patients. The isolates were collected from 82 US medical centers and susceptibility tested against ceftazidime-avibactam (avibactam at fixed 4 µg/mL) and comparators by reference broth microdilution methods...
December 4, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29206639/electrical-impedance-tomography-in-children-with-community-acquired-pneumonia-preliminary-data
#10
Marta B Mazzoni, Alessandra Perri, Anna M Plebani, Silvia Ferrari, Giacomo Amelio, Alessia Rocchi, Dario Consonni, Gregorio P Milani, Emilio F Fossali
BACKGROUND: Electrical impedance tomography (EIT) is a noninvasive pulmonary function test that provides spatial and temporal information of changes in regional lung ventilation. We aimed to assess the feasibility of EIT as a supplementary tool in the evaluation of community acquired pneumonia in children. Furthermore, we performed a prospective evaluation of regional lung ventilation changes during a six-month follow-up period. METHODS: We enrolled otherwise healthy children aged 2-15 years with radiological diagnosis of community acquired pneumonia on admission at pediatric emergency department...
September 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/29198542/kawasaki-disease-substantially-impacts-health-related-quality-of-life
#11
Soultana Kourtidou, April E Slee, Margaret E Bruce, Haaland Wren, Rita M Mangione-Smith, Michael A Portman
OBJECTIVE: To prospectively evaluate the acute impact of Kawasaki disease (KD) on health-related quality of life (HRQoL) and to assess deterioration in the HRQoL experienced by children with KD compared with other childhood diseases. STUDY DESIGN: We merged the Outcomes Assessment Program database obtained prospectively with the existing KD database and queried for KD admissions between 1 month and 13 years of age. HRQoL was evaluated with the parent-proxy Pediatric Quality of Life Inventory (PedsQL) 4...
November 30, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/29190798/human-pleural-fluid-is-a-potent-growth-medium-for-streptococcus-pneumoniae
#12
Natalia D Popowicz, Sally M Lansley, Hui M Cheah, Ian D Kay, Christine F Carson, Grant W Waterer, James C Paton, Jeremy S Brown, Y C Gary Lee
Empyema is defined by the presence of bacteria and/or pus in pleural effusions. However, the biology of bacteria within human pleural fluid has not been studied. Streptococcus pneumoniae is the most common cause of pediatric and frequent cause of adult empyema. We investigated whether S. pneumoniae can proliferate within human pleural fluid and if growth is affected by the cellular content of the fluid and/or characteristics of pneumococcal surface proteins. Invasive S. pneumoniae isolates (n = 24) and reference strain recovered from human blood or empyema were inoculated (1...
2017: PloS One
https://www.readbyqxmd.com/read/29189614/acquired-infection-and-antimicrobial-utilization-during-initial-nicu-hospitalization-in-infants-with-congenital-diaphragmatic-hernia
#13
Sarah Keene, Karna Murthy, Eugenia Pallotto, Beverly Brozanski, Jason Gien, Isabella Zaniletti, Cheryl Hulbert, Ruth Seabrook, Natalie Rintoul, Louis Chicoine, Nicolas Porta, Theresa R Grover
BACKGROUND: In addition to substantial medical and surgical intervention, neonates with congenital diaphragmatic hernia (CDH) often have concurrent concerns for acquired infection. However, few studies focus on infection and corresponding antimicrobial utilization in this population. METHODS: The Children's Hospital Neonatal Database was queried for CDH infants hospitalized from Jan 2010- Feb 2016. Patient charts were linked to the Pediatric Health Information Systems (PHIS) database...
November 16, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29184760/rhabdomyolysis-with-different-etiologies-in-childhood
#14
Demet Alaygut, Meral Torun Bayram, Belde Kasap, Alper Soylu, Mehmet Türkmen, Salih Kavukcu
AIM: To investigate different etiologies and management of the rhabdomyolysis in children. METHODS: Eight pediatric rhabdomyolysis cases who applied to the Dokuz Eylul University Faculty of Medicine Department of Pediatric Nephrology with different etiologies between January 2004 and January 2012 were evaluated in terms of age, gender, admission symptoms, physical examination findings, factors provoking rhabdomyolysis, number of rhabdomyolysis attacks, laboratory results, family history and the final diagnosis received after the treatment...
November 8, 2017: World Journal of Clinical Pediatrics
https://www.readbyqxmd.com/read/29181890/acute-kidney-injury-induced-by-concomitant-use-of-vancomycin-and-piperacillin-tazobactam-in-pediatrics
#15
Manal Abouelkheir, Sarah Alsubaie
BACKGROUND: Vancomycin is very commonly used in combination with piperacillin-tazobactam (PTZ) as an initial empiric therapy for moderate to severe infections, whenever coverage for both methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa is required. The combination of vancomycin and PTZ in adults has recently been reported to significantly increase the risk of developing acute kidney injury (AKI) relative to vancomycin monotherapy; such reports in pediatrics are sparse...
November 27, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29165755/research-on-the-correlation-between-the-fibrinogen-%C3%AE-and-attack-of-pediatric-pneumonia
#16
G Liu, H-W Wu, Z-G Li
OBJECTIVE: To investigate the correlation of the gene polymorphism of β-148C/T of fibrinogen with the expression of fibrinogen and the attack of pediatric pneumonia. PATIENTS AND METHODS: We employed polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) to detect the gene polymorphism of beta-fibrinogen gene-148C/T (β-148C/T). The expression level of fibrinogen in plasma was measured using enzyme-linked immunosorbent assay (ELISA), and the expression level of fibrinogen β protein was determined using Western-blot method...
October 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29165513/-a-five-year-experience-with-zoonotic-salmonella-at-a-pediatric-reference-centre
#17
Patricia Barrios, Federica Badía, Valentina Misa, M Inés Mota, Arací Martínez, Hebert Mariño, Gabriela Algorta, Javier Prego, M Catalina Pírez
BACKGROUND: Salmonella can cause asymptomatic infections, diarrhea, bacteremia and focal infections such as meningitis and osteomyelitis. AIM: To describe clinical and microbiological aspects of infections by Salmonella spp. in children in a pediatric referral hospital: Centro Hospitalario Pereira Rossell, in Montevideo, Uruguay. MATERIALS AND METHODS: Descriptive and retrospective study of 46 patients, from which Salmonella spp was isolated between January 1, 2005 and December 31, 2010...
August 2017: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/29164080/the-incidence-and-short-term-outcomes-of-acute-respiratory-illness-with-cough-in-children-from-a-socioeconomically-disadvantaged-urban-community-in-australia-a-community-based-prospective-cohort-study
#18
Kerry K Hall, Anne B Chang, Jennie Anderson, Daniel Arnold, Vikas Goyal, Melissa Dunbar, Michael Otim, Kerry-Ann F O'Grady
Background: Acute respiratory illnesses with cough (ARIwC) are predominant causes of morbidity in Australian Indigenous children; however, data on disease burden in urban communities are scarce. This study aimed to determine the incidence of ARIwC, the predictors of recurrent (≥4 episodes) ARIwC, and development of chronic cough following an ARIwC in urban, predominantly Indigenous, children aged <5 years from northern Brisbane, Australia. Methods: Prospective cohort study of children aged <5 years registered with a primary healthcare center...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29162982/future-directions-and-molecular-basis-of-ventilator-associated-pneumonia
#19
REVIEW
Kubra Aykac, Yasemin Ozsurekci, Sevgen Tanir Basaranoglu
Mechanical ventilation is a lifesaving treatment and has complications such as ventilator associated pneumonia (VAP) that lead to high morbidity and mortality. Moreover VAP is the second most common hospital-acquired infection in pediatric intensive care units. Although it is still not well understood, understanding molecular pathogenesis is essential for preventing and treating pneumonia. A lot of microbes are detected as a causative agent of VAP. The most common isolated VAP pathogens in pediatric patients are Staphylococcus aureus, Pseudomonas aeruginosa, and other gram negative bacteria...
2017: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://www.readbyqxmd.com/read/29159658/lung-necrosectomy-in-pediatric-patients-with-necrotizing-pneumonia
#20
Francina V Bolaños-Morales, Emmanuel Peña Gómez-Portugal, María E Aguilar-Mena, Patricio J Santillán-Doherty, Avelina Sotres-Vega, J Alfredo Santibáñez-Salgado
INTRODUCTION: Necrotizing pneumonia is the consolidation of lung parenchyma with destruction and necrosis, forming solitary or multiloculated radiolucent foci. When antibiotic treatment fails and clinical course does not improve, patients might need lung tissue resection: segmentectomy, lobectomy or bilobectomy. We have performed a more conservative surgical approach in pediatric patients with necrotizing pneumonia, lung necrosectomy: resection of unviable necrotic tissue, to preserve more healthy and potentially recoverable lung parenchyma...
November 20, 2017: General Thoracic and Cardiovascular Surgery
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