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cervical MS lesions

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https://www.readbyqxmd.com/read/29909771/focal-and-diffuse-cervical-spinal-cord-damage-in-patients-with-early-relapsing-remitting-ms-a-multicentre-magnetisation-transfer-ratio-study
#1
Benoît Combès, Anne Kerbrat, Jean Christophe Ferré, Virginie Callot, Josefina Maranzano, Atef Badji, Emmanuelle Le Page, Pierre Labauge, Xavier Ayrignac, Clarisse Carra Dallière, Nicolas Menjot de Champfleur, Jean Pelletier, Adil Maarouf, Jérôme de Seze, Nicolas Collongues, David Brassat, Françoise Durand-Dubief, Christian Barillot, Elise Bannier, Gilles Edan
BACKGROUND: Studies including patients with well-established multiple sclerosis (MS) have shown a significant and disability-related reduction in the cervical spinal cord (SC) magnetisation transfer ratio (MTR). OBJECTIVES: The objectives are to (1) assess whether MTR reduction is already measurable in the SC of patients with early relapsing-remitting multiple sclerosis (RRMS) and (2) describe its spatial distribution. METHODS: We included 60 patients with RRMS <12  months and 34 age-matched controls at five centres...
June 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29781383/preferential-spinal-cord-volume-loss-in-primary-progressive-multiple-sclerosis
#2
Charidimos Tsagkas, Stefano Magon, Laura Gaetano, Simon Pezold, Yvonne Naegelin, Michael Amann, Christoph Stippich, Philippe Cattin, Jens Wuerfel, Oliver Bieri, Till Sprenger, Ludwig Kappos, Katrin Parmar
BACKGROUND: Little is known on longer term changes of spinal cord volume (SCV) in primary progressive multiple sclerosis (PPMS). OBJECTIVE: Longitudinal evaluation of SCV loss in PPMS and its correlation to clinical outcomes, compared to relapse-onset multiple sclerosis (MS) subtypes. METHODS: A total of 60 MS age-, sex- and disease duration-matched patients (12 PPMS, each 24 relapsing-remitting (RRMS) and secondary progressive MS (SPMS)) were analysed annually over 6 years of follow-up...
May 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29730588/phase-sensitive-reconstruction-of-t1-weighted-inversion-recovery-in-the-evaluation-of-the-cervical-cord-lesions-in-multiple-sclerosis-is-it-similarly-eligible-in-1-5-t-magnet-fields
#3
A Shayganfar, A H Sarrami, S Fathi, V Shaygannejad, S Shamsian
BACKGROUND: In primary studies with 3 T Magnets, phase sensitive reconstruction of T1-weighted inversion recovery (PSIR) have showed ability to depict the cervical multiple sclerosis (MS) lesions some of which may not be detected by short tau inversion recovery (STIR). Regarding to more availability of 1.5 T MRI, this study was designed to evaluate the eligibility of PSIR in 1.5 T for detection of spinal cord MS lesions. METHOD: In a study between September 2016 till March 2017 the patients with proven diagnosis of MS enrolled to the study...
April 22, 2018: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29724765/imaging-differences-between-neuromyelitis-optica-spectrum-disorders-and-multiple-sclerosis-a-multi-institutional-study-in-japan
#4
H Tatekawa, S Sakamoto, M Hori, Y Kaichi, A Kunimatsu, K Akazawa, T Miyasaka, H Oba, T Okubo, K Hasuo, K Yamada, T Taoka, S Doishita, T Shimono, Y Miki
BACKGROUND AND PURPOSE: Both clinical and imaging criteria must be met to diagnose neuromyelitis optica spectrum disorders and multiple sclerosis. However, neuromyelitis optica spectrum disorders are often misdiagnosed as MS because of an overlap in MR imaging features. The purpose of this study was to confirm imaging differences between neuromyelitis optica spectrum disorders and MS with visually detailed quantitative analyses of large-sample data. MATERIALS AND METHODS: We retrospectively examined 89 consecutive patients with neuromyelitis optica spectrum disorders (median age, 51 years; range, 16-85 years; females, 77; aquaporin 4 immunoglobulin G-positive, 93%) and 89 with MS (median age, 36 years; range, 18-67 years; females, 68; relapsing-remitting MS, 89%; primary-progressive MS, 7%; secondary-progressive MS, 2%) from 9 institutions across Japan (April 2008 to December 2012)...
May 3, 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29707519/molecular-signatures-of-high-grade-cervical-lesions
#5
Andreia M Porcari, Fernanda Negrão, Guilherme Lucas Tripodi, Denise Rocha Pitta, Elisabete Aparecida Campos, Douglas Munhoz Montis, Aline M A Martins, Marcos N Eberlin, Sophie F M Derchain
Cervical cancer is the fourth most common neoplasia in women and the infection with human papilloma virus (HPV) is its necessary cause. Screening methods, currently based on cytology and HPV DNA tests, display low specificity/sensitivity, reducing the efficacy of cervical cancer screening programs. Herein, molecular signatures of cervical cytologic specimens revealed by liquid chromatography-mass spectrometry (LC-MS), were tested in their ability to provide a metabolomic screening for cervical cancer. These molecules were tested whether they could clinically differentiate insignificant HPV infections from precancerous lesions...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29664341/cervical-cord-t1-weighted-hypointense-lesions-at-mr-imaging-in-multiple-sclerosis-relationship-to-cord-atrophy-and-disability
#6
Paola Valsasina, Mohammed Aboulwafa, Paolo Preziosa, Roberta Messina, Andrea Falini, Giancarlo Comi, Massimo Filippi, Maria A Rocca
Purpose To characterize the spatial distribution of cervical cord T1-weighted hypointense lesions in patients with multiple sclerosis (MS) and analyze their association with cord atrophy and disability. Materials and Methods For this prospective study that took place between 2014 and 2016, 3.0-T high-resolution T1-weighted cervical cord magnetic resonance (MR) images and clinical evaluations were obtained from 82 patients with relapsing-remitting MS (RRMS), 33 patients with secondary progressive MS (SPMS), 25 patients with primary progressive MS (PPMS), and 35 sex-matched healthy control participants...
April 17, 2018: Radiology
https://www.readbyqxmd.com/read/29609231/-characteristics-of-invisible-cervical-intraepithelial-neoplasia-%C3%A2-under-colposcopy
#7
Q Chen, H Du, C Wang, J L Tang, R F Wu
Objective: To explore the human papilomavirus (HPV) genotypes and epithelial thickness of invisible cervical intraepithelial neoplasia Ⅲ (CIN Ⅲ) under colposcopy. Methods: One hundred and sixty-nine biopsies from 93 patients with a final diagnosis of CIN Ⅲ were extracted from the Shenzhen cervical cancer screening trial Ⅱ (SHENCCAST Ⅱ) . The SHENCCAST Ⅱ was conducted from 2009 to 2010. All the cervical blocks from these patients were re-cut and placed on 6 slides, i.e. sandwich model, with the top and bottom sections being stained with HE, the top second be processed for other studies, 3 sections for HPV genotypes by matrix-assisted laser desorption ionization-time of flight-mass spectrometry (MALDI-TOF-MS) assay...
March 25, 2018: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/29523171/clinical-feasibility-of-umbilical-cord-tissue-derived-mesenchymal-stem-cells-in-the-treatment-of-multiple-sclerosis
#8
Neil H Riordan, Isabela Morales, Giselle Fernández, Nicole Allen, Neal E Fearnot, Michael E Leckrone, Dedra Jones Markovich, Darla Mansfield, Dorita Avila, Amit N Patel, Santosh Kesari, Jorge Paz Rodriguez
BACKGROUND: Multiple sclerosis (MS) is a progressively debilitating neurological condition in which the immune system abnormally erodes the myelin sheath insulating the nerves. Mesenchymal stem cells (MSC) have been used in the last decade to safely treat certain immune and inflammatory conditions. METHODS: A safety and feasibility study was completed on the use of umbilical cord MSC (UCMSC) as a treatment for MS. In this 1-year study, consenting subjects received seven intravenous infusions of 20 × 106 UCMSC over 7 days...
March 9, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29503547/pediatric-onset-multiple-sclerosis-in-egypt-a-multi-center-registry-of-186-patients
#9
Sherif M Hamdy, Maged Abdel-Naseer, Nevin M Shalaby, Alaa Elmazny, Marian Girgis, Mona A Nada, Amr Hassan, Husam S Mourad, Mohamed I Hegazy, Ahmed Abdelalim, Nirmeen A Kishk, Noha T Abokrysha, Shaimaa A Genedy, Ehab A Essawy, Hatem S Shehata
Introduction: Although the frequency of pediatric-onset multiple sclerosis (POMS) has increased in recent decades, it is still highly uncommon, which creates a need for the involvement of more registries from various clinical centers. Objective: To characterize the demographic, clinical, and paraclinical features of Egyptian patients with POMS. Patients and methods: A retrospective chart review study was undertaken on 237 Egyptian patients with demyelinating events which started before the age of 18 years who attended one of five tertiary referral centers in Cairo, Egypt...
2018: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29501083/the-clinical-features-of-combined-central-and-peripheral-demyelination-in-chinese-patients
#10
Yan-Qin Wang, Han Chen, Wu-Ping Zhuang, Hong-Lei Li
BACKGROUND: Combined central and peripheral demyelination (CCPD) is rare and has never been reported as a spectrum disease in Han Chinese population. OBJECTIVES: To study the clinical features of CCPD in Han Chinese patients. METHODS: Twenty-two CCPD patients were selected from 788 demyelination cases. We reviewed and compared the clinical manifestation, laboratory data, electrophysiological examination, MRI and the prognosis. RESULTS: CCPD patients presented with sensory disturbance (86...
April 15, 2018: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/29435472/cervical-spinal-cord-atrophy-an-early-marker-of-progressive-ms-onset
#11
Burcu Zeydan, Xinyi Gu, Elizabeth J Atkinson, B Mark Keegan, Brian G Weinshenker, Jan-Mendelt Tillema, Daniel Pelletier, Christina J Azevedo, Christine Lebrun-Frenay, Aksel Siva, Darin T Okuda, Kejal Kantarci, Orhun H Kantarci
Objective: To assess whether cervical spinal cord atrophy heralds the onset of progressive MS. Methods: We studied 34 individuals with radiologically isolated syndrome (RIS) and 31 patients with relapsing-remitting MS (RRMS) age matched to 25 patients within a year of onset of secondary progressive MS (SPMS). Two raters independently measured (twice per rater) the cervical spinal cord average segmental area (CASA) (mm2 ) of axial T2-weighted images between C2 and C7 landmarks...
March 2018: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/29402285/-18-f-vc701-pet-and-mri-in-the-in-vivo-neuroinflammation-assessment-of-a-mouse-model-of-multiple-sclerosis
#12
Sara Belloli, Lucia Zanotti, Valentina Murtaj, Cristina Mazzon, Giuseppe Di Grigoli, Cristina Monterisi, Valeria Masiello, Leonardo Iaccarino, Andrea Cappelli, Pietro Luigi Poliani, Letterio Salvatore Politi, Rosa Maria Moresco
BACKGROUND: Positron emission tomography (PET) using translocator protein (TSPO) ligands has been used to detect neuroinflammatory processes in neurological disorders, including multiple sclerosis (MS). The aim of this study was to evaluate neuroinflammation in a mouse MS model (EAE) using TSPO-PET with 18 F-VC701, in combination with magnetic resonance imaging (MRI). METHODS: MOG35-55 /CFA and pertussis toxin protocol was used to induce EAE in C57BL/6 mice. Disease progression was monitored daily, whereas MRI evaluation was performed at 1, 2, and 4 weeks post-induction...
February 5, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29388719/multi-compartmental-diffusion-characterization-of-the-human-cervical-spinal-cord-in-vivo-using-the-spherical-mean-technique
#13
Samantha By, Junzhong Xu, Bailey A Box, Francesca R Bagnato, Seth A Smith
The purpose of this work was to evaluate the feasibility and reproducibility of the spherical mean technique (SMT), a multi-compartmental diffusion model, in the spinal cord of healthy controls, and to assess its ability to improve spinal cord characterization in multiple sclerosis (MS) patients at 3 T. SMT was applied in the cervical spinal cord of eight controls and six relapsing-remitting MS patients. SMT provides an elegant framework to model the apparent axonal volume fraction vax , intrinsic diffusivity Dax , and extra-axonal transverse diffusivity Dex_perp (which is estimated as a function of vax and Dax ) without confounds related to complex fiber orientation distribution that reside in diffusion MRI modeling...
April 2018: NMR in Biomedicine
https://www.readbyqxmd.com/read/29359174/quantitative-spinal-cord-mri-in-radiologically-isolated-syndrome
#14
Paula Alcaide-Leon, Kateryna Cybulsky, Stephanie Sankar, Courtney Casserly, General Leung, Marika Hohol, Daniel Selchen, Xavier Montalban, Aditya Bharatha, Jiwon Oh
Objectives: To assess whether quantitative spinal cord MRI (SC-MRI) measures, including atrophy, and diffusion tensor imaging (DTI) and magnetization transfer imaging metrics were different in radiologically isolated syndrome (RIS) vs healthy controls (HCs). Methods: Twenty-four participants with RIS and 14 HCs underwent cervical SC-MRI on a 3T magnet. Manually segmented regions of interest circumscribing the spinal cord cross-sectional area (SC-CSA) between C3 and C4 were used to extract SC-CSA, fractional anisotropy, mean, perpendicular, and parallel diffusivity (MD, λ⊥ , and λ|| ) and magnetization transfer ratio (MTR)...
March 2018: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/29247360/cervical-vestibular-evoked-myogenic-potentials-in-patients-with-multiple-sclerosis-sensitive-in-detecting-brainstem-involvement
#15
Gökçe Kavasoğlu, Figen Gökçay, Nur Yüceyar, Neşe Çelebisoy
Cervical vestibular-evoked myogenic potentials (cVEMPs) are accepted to demonstrate the vestibulo-collic reflex. However, the brainstem pathway is still not fully understood. The aim of the study was to evaluate the contribution of cVEMPs to detection of brainstem involvement in multiple sclerosis (MS). Thirty patients fulfilling the criteria for definite MS were included in the study. All were newly diagnosed cases, admitted due to an attack with active lesions on MRI. Thirty-one age- and sex-matched healthy controls constituted the control group...
February 2018: Neurological Sciences
https://www.readbyqxmd.com/read/29237964/myeloid-sarcoma-a-clinicopathological-study-with-emphasis-on-diagnostic-difficulties
#16
Ranjini Kudva, Vidya Monappa, Girish Solanke, Manna Valiathan, Anuradha C K Rao, V Geetha
BACKGROUND: Myeloid sarcoma (MS) is a rare tumor composed of proliferation of myeloid precursors at extramedullary sites. They can arise de-novo or in association with hematological malignancies, most commonly acute myeloid leukemia. Clinically, it can masquerade as an abscess, cutaneous ulcer, or mass lesion. Morphologically, MS can mimic a variety of small round cell tumors including lymphomas and rhabdomyosarcoma. AIMS: (1) To study the clinical presentations and laboratory findings in patients with MS; (2) to revisit the histomorphological findings and the differential diagnosis of MS; (3) to evaluate the diagnostic role of immunohistochemistry (IHC) and determine the useful markers for accurate diagnosis of MS...
October 2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/29157955/development-of-a-goat-model-for-evaluation-of-withaferin-a-cervical-implants-for-the-treatment-of-cervical-intraepithelial-neoplasia
#17
Leslie C Sherwood, Farrukh Aqil, Manicka V Vadhanam, Jeyaprakash Jeyabalan, Radha Munagala, David Hoetker, Sanjay Srivastava, Inder P Singh, Scott Cambron, Martin O'Toole, Wendy Spencer, Lynn P Parker, Ramesh C Gupta
Cervical cancer is caused by human papillomavirus (HPV). The disease develops over many years through a series of precancerous lesions. Cervical cancer can be prevented by HPV-vaccination, screening and treatment of precancer before development of cervical cancer. The treatment of high-grade cervical dysplasia (CIN2+ ) has traditionally been by cervical conization. Surgical procedures are associated with increased risk of undesirable side effects including bleeding, infection, scarring (stenosis), infertility and complications in later pregnancies...
December 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/28951942/proton-density-fat-suppressed-mri-in-3t-increases-the-sensitivity-of-multiple-sclerosis-lesion-detection-in-the-cervical-spinal-cord
#18
Efstratios Karavasilis, George Velonakis, George Argiropoulos, Athanasios Athanasakos, Loukia S Poulou, Panagiotis Toulas, Nikolaos L Kelekis, Efstathios P Efstathopoulos
PURPOSE: Considering the number of multiple sclerosis (MS) patients referred for clinical spinal cord imaging, the optimization of imaging protocols plays a crucial role. We aimed to evaluate the use of proton density (PD) turbo spin-echo (TSE) with spectral attenuated inversion recovery (SPAIR) fat suppression and compare it with the currently recommended T2-TSE-SPAIR in sagittal plane in cervical spinal cord imaging. METHODS: In this study 35 MS patients with clinically suspected or known spinal cord lesions were scanned on a 3...
September 26, 2017: Clinical Neuroradiology
https://www.readbyqxmd.com/read/28761809/evaluating-single-point-quantitative-magnetization-transfer-in-the-cervical-spinal-cord-application-to-multiple-sclerosis
#19
Alex K Smith, Samantha By, Bailey D Lyttle, Richard D Dortch, Bailey A Box, Lydia J Mckeithan, Saakshi Thukral, Francesca Bagnato, Siddharama Pawate, Seth A Smith
Spinal cord (SC) damage is linked to clinical deficits in patients with multiple sclerosis (MS), however, conventional MRI methods are not specific to the underlying macromolecular tissue changes that may precede overt lesion detection. Single-point quantitative magnetization transfer (qMT) is a method that can provide high-resolution indices sensitive to underlying macromolecular composition in a clinically feasible scan time by reducing the number of MT-weighted acquisitions and utilizing a two-pool model constrained by empirically determined constants...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28725551/cervical-cord-myelin-water-imaging-shows-degenerative-changes-over-one-year-in-multiple-sclerosis-but-not-neuromyelitis-optica-spectrum-disorder
#20
Anna J E Combes, Lucy Matthews, Jimmy S Lee, David K B Li, Robert Carruthers, Anthony L Traboulsee, Gareth J Barker, Jacqueline Palace, Shannon Kolind
Spinal cord pathology is a feature of both neuromyelitis optica spectrum disorder (NMOSD) and relapsing-remitting multiple sclerosis (MS). While subclinical disease activity has been described in MS using quantitative magnetic resonance imaging measures, current evidence suggests that neurodegeneration is absent between relapses in NMOSD, although most evidence comes from brain studies. We aimed to assess cross-sectional differences and longitudinal changes in myelin integrity in relapse-free MS and NMOSD subjects over one year...
2017: NeuroImage: Clinical
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