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JOURNAL ARTICLE
Xiaohong Sun, Xiaojing Sun
OBJECTIVE: The objective of this study was to assess the prevalence of high-risk HPV infection in married women in Longgang District, Shenzhen, and to analyze the distribution of HPV subtypes across different age groups while identifying risk factors associated with HPV infection. METHODS: 1. From January 2018 to December 2020, 209,627 married women in Longgang District were selected as study subjects, using high-risk HPV testing as the primary screening means. HPV 16 or 18 positive directly referred to colposcopy, other types positive continued liquid-based thin-layer cytology (TCT) examination, if ≥ ASCUS, referred to colposcopy, and biopsy if necessary...
April 5, 2024: Alternative Therapies in Health and Medicine
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JOURNAL ARTICLE
Naosuke Kamei, Toshio Nakamae, Toshiaki Maruyama, Kazuto Nakao, Fadlyansyah Farid, Hiroki Fukui, Nobuo Adachi
STUDY DESIGN: A retrospective case-control study. OBJECTIVE: To characterize the motor evoked potential (MEP) when the epiconus or conus medullaris is compressed by a fracture of the T12 or L1 vertebra. SUMMARY OF BACKGROUND DATA: Although the characteristics of compressive cervical and thoracic myelopathy with transcranial magnetic stimulation MEP have been reported, the MEP parameters in compressive disorders of the epiconus and conus medullaris have not yet been characterized...
March 20, 2024: Spine
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JOURNAL ARTICLE
Alex D Waldman, Cecilia Catania, Marco Pisa, Mark Jenkinson, Michael J Lenardo, Gabriele C DeLuca
Spinal cord pathology is a major determinant of irreversible disability in progressive multiple sclerosis. The demyelinated lesion is a cardinal feature. The well-characterised anatomy of the spinal cord and new analytic approaches allows the systematic study of lesion topography and its extent of inflammatory activity unveiling new insights into disease pathogenesis. We studied cervical, thoracic, and lumbar spinal cord tissue from 119 pathologically confirmed multiple sclerosis cases. Immunohistochemistry was used to detect demyelination (PLP) and classify lesional inflammatory activity (CD68)...
March 9, 2024: Acta Neuropathologica
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JOURNAL ARTICLE
Timothy Reynold U Lim, Sunitha P Kumaran, Suradech Suthiphosuwan, Adrian I Espiritu, Ashley Jones, Amy Wei Lin, Jiwon Oh, Aditya Bharatha
BACKGROUND: Performing routine brain magnetic resonance imaging (MRI) is widely accepted as the standard of care for disease monitoring in multiple sclerosis (MS), but the utility of performing routine spinal cord (SC) MRI for this purpose is still debatable. OBJECTIVE: This study aimed to measure the frequency of new isolated cervical spinal cord lesions (CSLs) in people with MS (pwMS) undergoing routine brain and cervical SC-MRI for disease monitoring and determine the factors associated with the development of new CSLs and their prognostic value...
February 28, 2024: Multiple Sclerosis: Clinical and Laboratory Research
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JOURNAL ARTICLE
B Yagdiran, B T Cakir, H Cetin
BACKGROUND: Multiple Sclerosis (MS) is the most common cause of non-traumatic disability in young adults. Spinal cord involvement is observed in 55-75% of patients with MS. AIM: To identify the strengths and shortcomings of sagittal phase-sensitive inversion recovery (PSIR), sagittal proton density/T2-weighted (PD/T2W), and axial turbo inversion recovery magnitude (TIRM) sequences in the detection of cervical MS plaques by comparing with routine sequences (axial and sagittal T2W, sagittal T1W, sagittal TIRM, fat-suppressed contrast T1W) and therefore determine their diagnostic contributions...
February 1, 2024: Nigerian Journal of Clinical Practice
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JOURNAL ARTICLE
Carmen Tur, Marco Battiston, Marios C Yiannakas, Sara Collorone, Alberto Calvi, Ferran Prados, Baris Kanber, Francesco Grussu, Antonio Ricciardi, Patrizia Pajak, Daniele Martinelli, Torben Schneider, Olga Ciccarelli, Rebecca S Samson, Claudia Am Gandini Wheeler-Kingshott
BACKGROUND: We assessed the ability of a brain-and-cord-matched quantitative magnetic resonance imaging (qMRI) protocol to differentiate patients with progressive multiple sclerosis (PMS) from controls, in terms of normal-appearing (NA) tissue abnormalities, and explain disability. METHODS: A total of 27 patients and 16 controls were assessed on the Expanded Disability Status Scale (EDSS), 25-foot timed walk (TWT), 9-hole peg (9HPT) and symbol digit modalities (SDMT) tests...
February 19, 2024: Multiple Sclerosis: Clinical and Laboratory Research
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JOURNAL ARTICLE
Wei Hsiung, Han-Ying Lin, Hsi-Hsien Lin, Yu-Cheng Yao, Shih-Tien Wang, Ming-Chau Chang, Po-Hsin Chou
BACKGROUND CONTEXT: No method currently exists for MRI-based determination of ossification of the posterior longitudinal ligament (OPLL) of the cervical spine using objective criteria. PURPOSE: The purpose of this study was to develop an MRI-based score to determine whether a lesion represents a cervical OPLL lesion and to establish the objective diagnostic value. STUDY DESIGN: Retrospective cohort in a single medical institution. PATIENT SAMPLE: Thirty-five patients undergoing surgery for OPLL (Group A) and 99 patients undergoing cervical disc arthroplasty for soft disc herniation (Group B) between 2011 and 2020 were retrospectively included...
February 14, 2024: Spine Journal: Official Journal of the North American Spine Society
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JOURNAL ARTICLE
Huiying Ouyang, Xiaojun Li, Haoyou Xu, Yibo Zhan, Zequan Zheng, Guixian Chen, Zhenzhen Lou, Haoxuan Chen, Jiahui Zhang, Hui Mao, Changlin Zhang, Lulu Qin, Yuanqi Zhao, Min Zhao
BACKGROUND: Pain is a common symptom in multiple sclerosis (MS), especially neuropathic pain, which has a significant impact on patients' mental and physical health and quality of life. However, risk factors that related to neuropathic pain, still remain unclear. OBJECTIVE: The study aimed to explore the risk factors of neuropathic pain among MS patients. MATERIALS AND METHODS: This retrospective study examined the consecutive patients diagnosed with MS in the Department of Neurology of Guangdong Provincial Hospital of Chinese Medicine between August 2011 and October 2022...
2024: Frontiers in Immunology
#9
REVIEW
Aishwarya Nagarajan, Sujeet Kumar Sinha
PURPOSE: This review article provides the readers with an in-depth insight in understanding and interpreting various research literatures on the masseter vestibular evoked myogenic potentials (mVEMP). The article also reviews the contemporary researches involving the clinical applications of the mVEMP. CONCLUSIONS: Masseter VEMP is an evolving yet clinically promising neuro-otology test tool that has recently gained more research interest and is considered an additional tool to diagnose various vestibular disorders...
January 2024: Journal of Otology
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JOURNAL ARTICLE
Sönke Peters, Fernando Bueno Neves, Monika Huhndorf, Friederike Gärtner, Klarissa Stürner, Olav Jansen, Mona Salehi Ravesh
PURPOSE: Multiple sclerosis (MS) is a prevalent autoimmune inflammatory disease. Besides cerebral manifestations, an affection of the spinal cord is typical; however, imaging of the spinal cord is difficult due to its anatomy. The aim of this study was to assess the diagnostic value of a 3D PSIR pulse sequencing at a 1.5 T magnetic field strength for both the cervical and thoracic spinal cord. METHODS: Phase sensitive inversion recovery (PSIR), short tau inversion recovery (STIR) and T2 -weighted (T2 -w) images of the spinal cord of 50 patients were separately evaluated by three radiologists concerning the number and location of MS lesions...
January 30, 2024: Clinical Neuroradiology
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JOURNAL ARTICLE
Erik H Middlebrooks, Vishal Patel, Xiangzhi Zhou, Sina Straub, John V Murray, Amit K Agarwal, Lela Okromelidze, Rahul B Singh, Alfonso S Lopez Chiriboga, Erin M Westerhold, Vivek Gupta, Sukhwinder Johnny Singh Sandhu, Iris V Marin Collazo, Shengzhen Tao
OBJECTIVES: Detection of infratentorial demyelinating lesions in multiple sclerosis (MS) presents a challenge in magnetic resonance imaging (MRI), a difficulty that is further heightened in 7 T MRI. This study aimed to assess the efficacy of a novel MRI approach, lesion-attenuated magnetization-prepared gradient echo acquisition (LAMA), for detecting demyelinating lesions within the posterior fossa and upper cervical spine on 7 T MRI and contrast its performance with conventional double-inversion recovery (DIR) and T2-weighted turbo spin echo sequences...
January 9, 2024: Investigative Radiology
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JOURNAL ARTICLE
Alessandro Cagol, Pascal Benkert, Lester Melie-Garcia, Sabine A Schaedelin, Selina Leber, Charidimos Tsagkas, Muhamed Barakovic, Riccardo Galbusera, Po-Jui Lu, Matthias Weigel, Esther Ruberte, Ernst-Wilhelm Radue, Özgür Yaldizli, Johanna Oechtering, Johannes Lorscheider, Marcus D'Souza, Bettina Fischer-Barnicol, Stefanie Müller, Lutz Achtnichts, Jochen Vehoff, Giulio Disanto, Oliver Findling, Andrew Chan, Anke Salmen, Caroline Pot, Claire Bridel, Chiara Zecca, Tobias Derfuss, Johanna M Lieb, Luca Remonda, Franca Wagner, Maria Isabel Vargas, Renaud A Du Pasquier, Patrice H Lalive, Emanuele Pravatà, Johannes Weber, Philippe C Cattin, Martina Absinta, Claudio Gobbi, David Leppert, Ludwig Kappos, Jens Kuhle, Cristina Granziera
BACKGROUND AND OBJECTIVES: Progression independent of relapse activity (PIRA) is a crucial determinant of overall disability accumulation in multiple sclerosis (MS). Accelerated brain atrophy has been shown in patients experiencing PIRA. In this study, we assessed the relation between PIRA and neurodegenerative processes reflected by (1) longitudinal spinal cord atrophy and (2) brain paramagnetic rim lesions (PRLs). Besides, the same relationship was investigated in progressive MS (PMS)...
January 9, 2024: Neurology
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JOURNAL ARTICLE
Raphael Schneider, Koroboshka Brand-Arzamendi, Timothy Reynold Lim, Lisa Eunyoung Lee, Melanie Guenette, Suradech Suthiphosuwan, Aditya Bharatha, Jiwon Oh
BACKGROUND: There are no specific, evidence-based recommendations for the management of individuals with radiologically isolated syndrome. Imaging and blood biomarkers may have prognostic utility. OBJECTIVE: To determine whether plasma neurofilament light protein (NfL) or glial fibrillary acidic protein (GFAP) levels in people with radiologically isolated syndrome correlate with imaging measures that have been shown to be associated with negative clinical outcomes in people with multiple sclerosis...
February 2024: Multiple Sclerosis: Clinical and Laboratory Research
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JOURNAL ARTICLE
Haider N Al-Tameemi, Hayder K Hassoun, Israa Q Mohammed, Zuhair Allebban
OBJECTIVES: Spinal cord abnormalities including cervical cord atrophy are common in multiple sclerosis (MS). This study aimed to assess the cervical spinal cord cross-sectional area (CSA) using magnetic resonance imaging (MRI) in MS patients. MATERIALS AND METHODS: Sixty participants were enrolled in this study (16 male and 44 female), 30 patients with MS, diagnosed according to the revised McDonald criteria, and 30 apparently healthy individuals as the control group...
2023: Journal of Neurosciences in Rural Practice
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JOURNAL ARTICLE
Margareta A Clarke, Rachael Cheek, Habeeb F Kazimuddin, Bryan Hernandez, Reece Clarke, Colin D McKnight, Joy Derwenskus, James Eaton, Rebecca Irlmeier, Fei Ye, Kristin P O'Grady, Baxter Rogers, Seth A Smith, Francesca Bagnato
BACKGROUND AND PURPOSE: Paramagnetic rims and the central vein sign (CVS) are proposed imaging markers of multiple sclerosis (MS) lesions. Using 7 tesla magnetic resonance imaging, we aimed to: (1) characterize the appearance of paramagnetic rim lesions (PRLs); (2) assess whether PRLs and the CVS are associated with higher levels of MS pathology; and (3) compare the characteristics between subjects with and without PRLs in early MS. METHODS: Prospective study of 32 treatment-naïve subjects around the time of diagnosis who were assessed for the presence of PRLs and the CVS...
November 29, 2023: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
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JOURNAL ARTICLE
Ivana Vrca, Blaž Jug, Željana Fredotović, Elma Vuko, Valentina Brkan, Loriana Šestić, Lea Juretić, Valerija Dunkić, Marija Nazlić, Dina Ramić, Sonja Smole Možina, Dario Kremer
Tropaeolum majus L. is a traditional medicinal plant with a wide range of biological activities due to the degradation products of the glucosinolate glucotropaeolin. Therefore, the goals of this study were to identify volatiles using gas chromatography-mass spectrometry analysis (GC-MS) of the hydrosols (HYs) isolated using microwave-assisted extraction (MAE) and microwave hydrodiffusion and gravity (MHG). Cytotoxic activity was tested against a cervical cancer cell line (HeLa), human colon cancer cell line (HCT116), human osteosarcoma cell line (U2OS), and healthy cell line (RPE1)...
November 18, 2023: Plants (Basel, Switzerland)
#17
JOURNAL ARTICLE
Margareta A Clarke, Atlee A Witt, Ryan K Robison, Sawyer Fleishman, Anna J E Combes, Delaney Houston, Logan E Prock, Grace Sweeney, Kristin P O'Grady, Colin D McKnight, Seth A Smith
BACKGROUND: Susceptibility-weighted imaging (SWI) has been extensively studied in the brain and in diseases of the central nervous system such as multiple sclerosis (MS) providing unique opportunities to visualize cerebral vasculature and disease-related pathology, including the central vein sign (CVS) and paramagnetic rim lesions (PRLs). However, similar studies evaluating SWI in the spinal cord of patients with MS remains severely limited. PURPOSE: Based on our previous findings of enlarged spinal vessels in MS compared to healthy controls (HCs), we developed high-field SWI acquisition and processing methods for the cervical spinal cord with application in people with MS (pwMS) and HCs...
November 16, 2023: NeuroImage
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JOURNAL ARTICLE
Maja Rogić Vidaković, Ana Ćurković Katić, Sanda Pavelin, Antonia Bralić, Una Mikac, Joško Šoda, Ana Jerković, Angela Mastelić, Krešimir Dolić, Anita Markotić, Zoran Đogaš, Nikolina Režić Mužinić
Probing the cortic ospinal tract integrity by transcranial magnetic stimulation (TMS) could help to understand the neurophysiological correlations of multiple sclerosis (MS) symptoms. Therefore, the study objective was, first, to investigate TMS measures (resting motor threshold-RMT, motor evoked potential (MEP) latency, and amplitude) of corticospinal tract integrity in people with relapsing-remitting MS (pwMS). Then, the study examined the conformity of TMS measures with clinical disease-related (Expanded Disability Status Scale-EDSS) and magnetic resonance imaging (MRI) results (lesion count) in pwMS...
September 24, 2023: Bioengineering
#19
JOURNAL ARTICLE
Lili Geiger, Gergely Orsi, Tamás Cseh, Katalin Gombos, Zsolt Illés, Boldizsár Czéh
INTRODUCTION: Circulating microRNAs are promising biomarkers for multiple sclerosis (MS). Our aim was to correlate serum microRNA levels with various magnetic resonance imaging (MRI) parameters. METHODS: We recruited 50 MS patients and measured cervical spine and cerebral white matter lesions together with regional brain volumes. Microstructural changes in the white matter were investigated with diffusion tensor imaging. Magnetic resonance spectroscopy was performed to measure cerebral metabolites...
2023: Frontiers in Molecular Neuroscience
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JOURNAL ARTICLE
Haykel Snoussi, Julien Cohen-Adad, Benoît Combès, Élise Bannier, Slimane Tounekti, Anne Kerbrat, Christian Barillot, Emmanuel Caruyer
INTRODUCTION: Multiple sclerosis (MS) is an inflammatory disorder of the central nervous system. Although conventional magnetic resonance imaging (MRI) is widely used for MS diagnosis and clinical follow-up, quantitative MRI has the potential to provide valuable intrinsic values of tissue properties that can enhance accuracy. In this study, we investigate the efficacy of diffusion MRI in distinguishing MS lesions within the cervical spinal cord, using a combination of metrics extracted from diffusion tensor imaging and Ball-and-Stick models...
September 29, 2023: Brain and Behavior
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