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https://www.readbyqxmd.com/read/28514903/utility-of-the-central-motor-conduction-time-recorded-from-the-abductor-pollicis-brevis-and-the-abductor-digiti-minimi-muscles-in-patients-with-c6-7-myelopathy
#1
Yasuaki Imajo, Tsukasa Kanchiku, Hidenori Suzuki, Masahiro Funaba, Norihiro Nishida, Toshihiko Taguchi
OBJECTIVE: Central motor conduction time (CMCT) recorded from the abductor pollicis brevis (CMCT-APB) and abductor digiti minimi (CMCT-ADM) muscles may enable the evaluation of patients with C6-7 myelopathy. CMCT is more useful for the evaluation of the function of spinal cord than magnetic resonance imaging (MRI) findings. CMCT may be associated with age and height. However, there are few reports regarding CMCT-APB in normal subjects. This study aimed to investigate the relationships between age, height, and conduction parameters in normal subjects to assess the effectiveness of using CMCT-APB and CMCT-ADM for the evaluation of patients with C6-7 and C7-T1 myelopathy...
May 17, 2017: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/28443093/a-novel-cervical-spinal-cord-window-preparation-allows-for-two-photon-imaging-of-t-cell-interactions-with-the-cervical-spinal-cord-microvasculature-during-experimental-autoimmune-encephalomyelitis
#2
Neda Haghayegh Jahromi, Heidi Tardent, Gaby Enzmann, Urban Deutsch, Naoto Kawakami, Stefan Bittner, Dietmar Vestweber, Frauke Zipp, Jens V Stein, Britta Engelhardt
T-cell migration across the blood-brain barrier (BBB) is a crucial step in the pathogenesis of experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS). Two-photon intravital microscopy (2P-IVM) has been established as a powerful tool to study cell-cell interactions in inflammatory EAE lesions in living animals. In EAE, central nervous system inflammation is strongly pronounced in the spinal cord, an organ in which 2P-IVM imaging is technically very challenging and has been limited to the lumbar spinal cord...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28440978/methylation-status-of-p16ink4a-in-human-papillomavirus-associated-cancer-of-oral-cavity-and-oropharynx-in-northeastern-thailand
#3
Piyawut Swangphon, Chamsai Pientong, Ati Burassakarn, Patravoot Vatanasapt, Pilaiwan Kleebkaow, Natcha Patarapadungkit, Thanabut Treebupachatsakul, Supannee Promthet, Bunkerd Kongyingyoes, Tipaya Ekalaksananan
Background: Over-expression of p16INK4a protein is a biomarker for human papillomavirus (HPV)-associated cervical cancer. However, absence of p16INK4a protein expression in HPV-associated cancer of the oral cavity and oropharynx has been reported. Among a number of possible reasons for this is methylation, which is frequently noted in the promoter region of p16INK4a and is associated with silencing of the gene and disease severity. Methods: We investigated the relationships between p16INK4a protein expression, HPV infection and methylation status of the p16INK4a promoter in cancers of the oral cavity and oropharynx...
March 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28328841/increased-hpv-l1-gene-methylation-and-multiple-infection-status-lead-to-the-difference-of-cervical-epithelial-cell-lesion-in-different-ethnic-women-of-xinjiang-china
#4
Feng Yang-Chun, Zhang Yuan, Liu Cheng-Ming, Huang Yan-Chun, Ma Xiu-Min
Human papillomavirus (HPV) L1 gene methylation deeply involved in the progression and heterogeneity of cervical cell epithelial lesions. The DNA ploidy also represented the early lesions of cervical cell, and it was associated with different HPV infection status in different ethnic women. So, the research was to explore whether it was possible that HPV L1 gene methylation and HPV infection status as the risk factors to lead to the differences of cervical epithelial cells' lesions in different ethnics women...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28327094/finger-tapping-impairments-are-highly-sensitive-for-evaluating-upper-motor-neuron-lesions
#5
Afsaneh Shirani, Braeden D Newton, Darin T Okuda
BACKGROUND: Identifying highly sensitive and reliable neurological exam components are crucial in recognizing clinical deficiencies. This study aimed to investigate finger tapping performance differences between patients with CNS demyelinating lesions and healthy control subjects. METHODS: Twenty-three patients with multiple sclerosis or clinically isolated syndrome with infratentorial and/or cervical cord lesions on MRI, and 12 healthy controls were videotaped while tapping the tip of the index finger against the tip and distal crease of the thumb using both the dominant and non-dominant hand...
March 21, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28261936/characterizing-clinical-and-mri-dissociation-in-patients-with-multiple-sclerosis
#6
Brian C Healy, Guy J Buckle, Eman N Ali, Svetlana Egorova, Fariha Khalid, Shahamat Tauhid, Bonnie I Glanz, Tanuja Chitnis, Charles R G Guttmann, Howard L Weiner, Rohit Bakshi
BACKGROUND AND PURPOSE: Two common approaches for measuring disease severity in multiple sclerosis (MS) are the clinical exam and brain magnetic resonance imaging (MRI) scan. Although most patients show similar disease severity on both measures, some patients have clinical/MRI dissociation. METHODS: Subjects from a comprehensive care MS center who had a concurrent brain MRI, spinal cord MRI, clinical examination, and patient reported outcomes were classified into three groups based on the Expanded Disability Status Scale (EDSS) and cerebral T2 hyperintense lesion volume (T2LV)...
March 6, 2017: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://www.readbyqxmd.com/read/28174513/cervical-mucus-proteome-in-endometriosis
#7
Giuseppe Grande, Federica Vincenzoni, Domenico Milardi, Giuseppina Pompa, Domenico Ricciardi, Erika Fruscella, Francesca Mancini, Alfredo Pontecorvi, Massimo Castagnola, Riccardo Marana
BACKGROUND: Endometriosis is a chronic gynecological inflammatory disease characterized by the presence of functional endometrial glands and stroma outside of the uterine cavity. It affects 7-10% of women of reproductive age and up to 50% of women with infertility. The current gold standard for the diagnosis combines laparoscopic evaluation and biopsy of the visualized lesions. However, laparoscopy requires general anesthesia and developed surgical skills and it has a high procedural cost...
2017: Clinical Proteomics
https://www.readbyqxmd.com/read/28114622/association-between-serum-micrornas-and-magnetic-resonance-imaging-measures-of-multiple-sclerosis-severity
#8
Keren Regev, Brian C Healy, Fariha Khalid, Anu Paul, Renxin Chu, Shahamat Tauhid, Subhash Tummala, Camilo Diaz-Cruz, Radhika Raheja, Maria A Mazzola, Felipe von Glehn, Pia Kivisakk, Sheena L Dupuy, Gloria Kim, Tanuja Chitnis, Howard L Weiner, Roopali Gandhi, Rohit Bakshi
Importance: MicroRNAs (miRNAs) are promising multiple sclerosis (MS) biomarkers. Establishing the association between miRNAs and magnetic resonance imaging (MRI) measures of disease severity will help define their significance and potential impact. Objective: To correlate circulating miRNAs in the serum of patients with MS to brain and spinal MRI. Design, Setting, and Participants: A cross-sectional study comparing serum miRNA samples with MRI metrics was conducted at a tertiary MS referral center...
March 1, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28038775/spinal-cord-lesions-in-children-and-adolescents-with-multiple-sclerosis-magnetic-resonance-imaging
#9
Joanna Dębska, Katarzyna Kotulska-Józwiak, Piotr Pawliszak, Małgorzata Bilska, Dariusz Chmielewski, Iwona Puzio, Elżbieta Jurkiewicz
PURPOSE: The purpose of our study was to determine the prevalence of spinal cord lesions revealed by magnetic resonance (MR) imaging in children and adolescents with clinically definite multiple sclerosis (MS). MATERIAL AND METHODS: We retrospectively evaluated the spinal cord magnetic resonance examinations in a group of MS patients consisting of 58 children (37 girls and 21 boys) aged from 7 to 17.8 years (mean 13.7 years). All children met the criteria of clinically definite MS and had typical MS lesions revealed in the brain imaging...
January 2017: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/28017229/vestibular-evoked-myogenic-potentials-and-mri-in-early-multiple-sclerosis-validation-of-the-vemp-score
#10
Luka Crnošija, Magdalena Krbot Skorić, Tereza Gabelić, Ivan Adamec, Mario Habek
BACKGROUND: To validate the VEMP score as a measure of brainstem dysfunction in patients with the first symptom of multiple sclerosis (MS) (clinically isolated syndrome (CIS)) and to investigate the correlation between VEMP and brainstem MRI results. METHODS: 121 consecutive CIS patients were enrolled and brainstem functional system score (BSFS) was determined. Ocular VEMP (oVEMP) and cervical VEMP (cVEMP) were analyzed for latencies, conduction block and amplitude asymmetry ratio and the VEMP score was calculated...
January 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28017200/the-characteristics-of-spinal-imaging-in-different-types-of-demyelinating-diseases
#11
Chaisak Dumrikarnlert, Sasitorn Siritho, Pimwalai Chulapimphan, Chanon Ngamsombat, Chanjira Satukijchai, Naraporn Prayoonwiwat
BACKGROUND: Transverse myelitis is the common presentation in demyelinating conditions. OBJECTIVE: To determine the characteristics of spinal lesions among each type of demyelinating diseases. METHODS: Medical records and spinal imaging of patients who were [1] older than 18years, [2] had at least one attack of TM, [3] had available spinal MRI data and [4] were tested for aquaporin-4 antibody were included. RESULTS: One hundred and fifty-eight patients were eligible (27 clinically isolated syndrome [CIS], 38 MS, 55 seropositive neuromyelitis optica spectrum disorders [NMOSD], 9 seronegative NMOSD, and 29 idiopathic transverse myelitis [IDD-TM])...
January 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/27830953/radiologically-isolated-syndrome-watchful-waiting-vs-active-treatment
#12
Foziah Alshamrani, Hind Alnajashi, M Freedman
Neurologists are frequently consulted for patients who have white matter lesions discovered incidentally on their brain MRI, performed for reasons other than suspecting a demyelinating disease. The referring physician will question if the person has multiple sclerosis (MS). If the MRI is typical for MS but there are no clinical symptoms or signs suggestive of a demyelinating disorder, patients are diagnosed as having a Radiologically Isolated Syndrome (RIS). Areas covered: This is a timely review on RIS with a focus on treatment considerations...
May 2017: Expert Review of Neurotherapeutics
https://www.readbyqxmd.com/read/27651644/reproductive-tract-infections-and-premalignant-lesions-of-cervix-evidence-from-women-presenting-at-the-cancer-detection-centre-of-the-indian-cancer-society-delhi-2000-2012
#13
Subhojit Dey, Parika Pahwa, Arti Mishra, Jyotsna Govil, Preet K Dhillon
OBJECTIVES: Burden of cervical cancer (CC) is highest for women in low- and middle-income countries (LMICs). Human papillomavirus (HPV) is implicated as the necessary cause of CC although a number of other factors aid the long process of CC development. One among them is the presence of reproductive tract infections (RTIs). This study investigated the associations between RTIs and CC from India. METHODS: This study utilized secondary data from the Cancer Detection Centre of the ICS, Delhi...
October 2016: Journal of Obstetrics and Gynaecology of India
https://www.readbyqxmd.com/read/27638926/progressive-solitary-sclerosis-gradual-motor-impairment-from-a-single-cns-demyelinating-lesion
#14
B Mark Keegan, Timothy J Kaufmann, Brian G Weinshenker, Orhun H Kantarci, William F Schmalstieg, M Mateo Paz Soldan, Eoin P Flanagan
OBJECTIVE: To report patients with progressive motor impairment resulting from an isolated CNS demyelinating lesion in cerebral, brainstem, or spinal cord white matter that we call progressive solitary sclerosis. METHODS: Thirty patients were identified with (1) progressive motor impairment for over 1 year with a single radiologically identified CNS demyelinating lesion along corticospinal tracts, (2) absence of other demyelinating CNS lesions, and (3) no history of relapses affecting other CNS pathways...
October 18, 2016: Neurology
https://www.readbyqxmd.com/read/27625006/vertebral-hemangiomas-in-the-thoracic-spine-of-multiple-sclerosis-patients-are-connected-with-fewer-demyelinating-lesions-at-the-same-level-possible-impact-on-pathophysiology-and-clinical-course
#15
Maria Anagnostouli, Serafeim Katsavos, Andreas Kyrozis, Maria Gontika, Konstantinos I Voumvourakis, Elisabeth Kapaki
OBJECTIVES: Mechanisms of angiogenesis regulate multiple sclerosis (MS) lesions' evolution, displaying both neuroprotective and harmful effects. Factors traditionally considered as purely angiogenic, like vascular endothelial growth factor (VEGF), exert complex heterogenous actions on both neural and vascular malformation-derived tissues. Aim of this retrospective study was to examine, for the first time, potential associations between the presence of common vascular malformations, like vertebral hemangiomas (VHs), and several clinico-radiological MS parameters...
August 2016: Neurological Research
https://www.readbyqxmd.com/read/27491693/a-comparison-of-magnetization-transfer-methods-to-assess-brain-and-cervical-cord-microstructure-in-multiple-sclerosis
#16
Alfonso Lema, Courtney Bishop, Omar Malik, Miriam Mattoscio, Rehiana Ali, Richard Nicholas, Paolo A Muraro, Paul M Matthews, Adam D Waldman, Rexford D Newbould
BACKGROUND: Demyelination is a core pathological feature of multiple sclerosis (MS) and spontaneous remyelination appears to be an important mechanism for repair in the disease. Magnetization transfer ratio imaging (MTR) has been used extensively to evaluate demyelination, although limitations to its specificity are recognized. MT saturation imaging (MTsat) removes some of the T1 dependence of MTR. We have performed a comparative evaluation of MTR and MTsat imaging in a mixed group of subjects with active MS, to explore their relative sensitivity to pathology relevant to explaining clinical outcomes...
August 5, 2016: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://www.readbyqxmd.com/read/27459342/chemical-exchange-saturation-transfer-of-the-cervical-spinal-cord-at-7-t
#17
Adrienne N Dula, Siddharama Pawate, Lindsey M Dethrage, Benjamin N Conrad, Blake E Dewey, Robert L Barry, Seth A Smith
High-magnetic-field (7 T) chemical exchange saturation transfer (CEST) MRI provides information on the tissue biochemical environment. Multiple sclerosis (MS) affects the entire central nervous system, including the spinal cord. Optimal CEST saturation parameters found via simulation were implemented for CEST MRI in 10 healthy controls and 10 patients with MS, and the results were examined using traditional asymmetry analysis and a Lorentzian fitting method. In addition, T1 - and T2 *-weighted images were acquired for lesion localization and the transmitted B1 (+) field was evaluated to guide imaging parameters...
September 2016: NMR in Biomedicine
https://www.readbyqxmd.com/read/27448576/sympathetic-cardiovascular-and-sudomotor-functions-are-frequently-affected-in-early-multiple-sclerosis
#18
Mario Habek, Luka Crnošija, Mila Lovrić, Anamari Junaković, Magdalena Krbot Skorić, Ivan Adamec
OBJECTIVE: The aim of this study was to determine the prevalence of autonomic dysfunction using the composite autonomic scoring scale (CASS) and heart rate variability (HRV) in patients with clinically isolated syndrome (CIS) and to correlate autonomic dysfunction with other measures of MS disease activity. METHODS: CASS, HRV and plasma catecholamines during supine and tilted phase were performed in 104 CIS patients. MRI findings were analyzed for total number of lesions and the presence of brainstem and cervical spinal cord lesions...
July 22, 2016: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/27445966/the-contribution-of-cortical-lesions-to-a-composite-mri-scale-of-disease-severity-in-multiple-sclerosis
#19
Fawad Yousuf, Gloria Kim, Shahamat Tauhid, Bonnie I Glanz, Renxin Chu, Subhash Tummala, Brian C Healy, Rohit Bakshi
OBJECTIVE: To test a new version of the Magnetic Resonance Disease Severity Scale (v.3 = MRDSS3) for multiple sclerosis (MS), incorporating cortical gray matter lesions (CLs) from 3T magnetic resonance imaging (MRI). BACKGROUND: MRDSS1 was a cerebral MRI-defined composite scale of MS disease severity combining T2 lesion volume (T2LV), the ratio of T1 to T2LV (T1/T2), and whole brain atrophy [brain parenchymal fraction (BPF)]. MRDSS2 expanded the scale to include cerebral gray matter fraction (GMF) and upper cervical spinal cord area (UCCA)...
2016: Frontiers in Neurology
https://www.readbyqxmd.com/read/27244296/association-of-hla-genetic-risk-burden-with-disease-phenotypes-in-multiple-sclerosis
#20
Noriko Isobe, Anisha Keshavan, Pierre-Antoine Gourraud, Alyssa H Zhu, Esha Datta, Regina Schlaeger, Stacy J Caillier, Adam Santaniello, Antoine Lizée, Daniel S Himmelstein, Sergio E Baranzini, Jill Hollenbach, Bruce A C Cree, Stephen L Hauser, Jorge R Oksenberg, Roland G Henry
IMPORTANCE: Although multiple HLA alleles associated with multiple sclerosis (MS) risk have been identified, genotype-phenotype studies in the HLA region remain scarce and inconclusive. OBJECTIVES: To investigate whether MS risk-associated HLA alleles also affect disease phenotypes. DESIGN, SETTING, AND PARTICIPANTS: A cross-sectional, case-control study comprising 652 patients with MS who had comprehensive phenotypic information and 455 individuals of European origin serving as controls was conducted at a single academic research site...
July 1, 2016: JAMA Neurology
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