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Pioglitazon

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https://www.readbyqxmd.com/read/29786570/combination-of-metformin-and-pioglitazone-and-its-effect-in-treatment-of-comorbid-pathology
#1
Zlatoslava O Shaienko, Lyudmila Ye Bobyreva
OBJECTIVE: Introduction: The early development and high incidence of cardiovascular lesion in patients with type 2 diabetes mellitus is one of the most serious challenges for the diabetology worldwide. The aim: The purpose of the paper is to determine the dynamics of the insulin resistance indices in patients with type 2 diabetes mellitus concomitant with coronary heart disease in the combination therapy with metformin and pioglitazone during 3 and 6 months. PATIENTS AND METHODS: Materials and methods: 95 patients with type 2 diabetes mellitus and coronary heart disease have been treated and randomized into two groups: the comparison group (n=37), treated with metformin and sulfonylureas, and the study group (n=58), treated with metformin in combination with pioglitazone...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29780260/efficacy-and-safety-profile-of-once-weekly-dulaglutide-in-type-2-diabetes-a-report-on-the-emerging-new-data
#2
REVIEW
Anne J Kugler, Michael L Thiman
Dulaglutide is a once-weekly glucagon-like peptide-1 receptor agonist, which has been on the market in the USA since 2014. Dulaglutide has performed well in head-to-head studies against metformin, glargine, and sitagliptin, where its A1c lowering ranged from -0.78% to -1.64% over 52-104 weeks, and it consistently outperformed each of these agents. As an add-on therapy, dulaglutide provided additional A1c lowering of -1.4% to -1.44% over monotherapy with glimepiride or glargine at 24 and 28 weeks, respectively...
2018: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
https://www.readbyqxmd.com/read/29775878/repositioning-of-diabetes-treatments-for-depressive-symptoms-a-systematic-review-and-meta-analysis-of-clinical-trials
#3
REVIEW
Calum D Moulton, Christopher W P Hopkins, Khalida Ismail, Daniel Stahl
Depression is a common comorbidity in diabetes but conventional antidepressant treatments do not consistently improve outcomes. We tested whether established diabetes treatments can also improve depressive symptoms and examined biological correlates of response. We performed a multi-database systematic search of all clinical trials, which measured the effect of licensed diabetes treatments on depressive symptoms using a validated questionnaire. Results of randomised controlled trials (RCT's) were pooled for meta-analysis...
May 7, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29772284/effect-of-excipient-properties-water-activity-and-water-content-on-the-disproportionation-of-a-pharmaceutical-salt
#4
Mitulkumar A Patel, Suman Luthra, Sheri L Shamblin, Kapildev K Arora, Joseph F Krzyzaniak, Lynne S Taylor
Excipients are crucial components of most pharmaceutical formulations. In the case of a solid oral dosage formulation containing the salt form of a weakly ionizable drug, excipient selection is critical, as some excipients are known to cause salt disproportionation (conversion of salt to the free form). Therefore, robust formulation design necessitates an in-depth understanding of the factors impacting salt disproportionation during processing or storage as this can negatively impact product quality and performance...
May 14, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29764544/-effects-of-peroxisome-proliferator-activated-receptor-%C3%AE-toll-like-receptor-4-tumor-necrosis-factor-%C3%AE-targeted-pathway-on-hyperglycemia-induced-myocardium-inflammation-and-oxidative-stress
#5
Changle Liu, Ruimeng Liu, Xiaohan Wu, Peize Tan, Huaying Fu, Xinghua Wang, Tong Liu, Guangping Li
OBJECTIVE: To investigate the potential effects and mechanism on peroxisome proliferator-activated receptor γ-toll-like receptor 4-tumor necrosis factor-α (PPARγ-TLR4-TNF-α) targeted pathway on hyperglycemia induced myocardium inflammation and oxidative stress. METHODS: Thirty-two Japanese healthy adult rabbits were randomly divided into four groups with 8 rabbits in each group: normal control group (NC group), diabetes mellitus group (DM group), diabetes mellitus + pioglitazone 4 mg×kg-1 ×d-1 and 8 mg×kg-1 ×d-1 groups (DM+PGZ 4 mg and 8 mg groups)...
May 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29749987/the-preventive-role-of-pioglitazone-in-glycerol-induced-acute-kidney-injury-in-rats-during-two-different-treatment-periods
#6
Rama Mousleh, Shaza Al Laham, Ahmad Al-Manadili
Background: Acute kidney injury is the most life-threatening complication of rhabdomyolysis. Glycerol is commonly used to induce this injury. The aim was to investigate the renoprotective effects of pioglitazone and the possible advantage of administering the drug for a longer period. Methods: Twenty-four male Albino Wistar rats were randomly divided into 4 groups (n=6/group): (A) control, (B) glycerol (50%, 10 mL/kg intramuscularly), (C) glycerol+pioglitazone (10 mg/kg orally for 3 days), and (D) glycerol+pioglitazone (for 6 days)...
March 2018: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29744368/identification-of-potential-therapeutic-targets-in-the-liver-of-pioglitazone-treated-type-2-diabetes-sprague-dawley-rats-via-expression-profile-chip-and-itraq-assay
#7
Zhong-Xia Lu, Wen-Jun Xu, Yang-Sheng Wu, Chang-Yu Li, Yi-Tao Chen
The aim of the present study was to identify key antidiabetic nodes in the livers of pioglitazone-treated type 2 diabetes mellitus Sprague-Dawley rats by transcriptomic and proteomic analysis. Rats were randomly divided into the control, the diabetes model, and the pioglitazone-treated groups. After treatment with pioglitazone for 11 weeks, the effects on fasting blood glucose, body weight, and blood biochemistry parameters were evaluated. Microarray and iTRAQ analysis were used to determine the differentially expressed genes/proteins in rat livers...
2018: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29734669/co-administration-of-melatonin-effectively-enhances-the-therapeutic-effects-of-pioglitazone-on-mesenchymal-stem-cells-undergoing-indoxyl-sulfate-induced-senescence-through-modulation-of-cellular-prion-protein-expression
#8
Yong Seok Han, Sang Min Kim, Jun Hee Lee, Sang Hun Lee
BACKGROUND: Mesenchymal stem cells (MSCs) are a promising source for regenerative medicine. However, their therapeutic potential in patients with chronic kidney disease (CKD) is restricted by the presence of uremic toxins. To address this limitation, we explored the protective effect of melatonin and pioglitazone on MSCs undergoing senescence induced by the uremic toxin, indoxyl sulfate (IS). METHODS: MSC senescence was induced by IS, and the therapeutic effects of melatonin and pioglitazone were identified...
May 4, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29732719/evaluation-of-visceral-adipose-tissue-oxygenation-by-blood-oxygen-level-dependent-mri-in-zucker-diabetic-fatty-rats
#9
Hong-Jian Shi, Yan-Feng Li, Wen-Jie Ji, Zhi-Chun Lin, Wei Cai, Tao Chen, Bin Yuan, Xiu-Long Niu, Han-Ying Li, Wen Shu, Yu-Ming Li, Fei Yuan, Xin Zhou, Zhuoli Zhang
OBJECTIVE: This study aimed to investigate the feasibility of blood oxygen level-dependent magnetic resonance imaging (BOLD-MRI) to evaluate visceral adipose tissue (VAT) oxygenation in Zucker diabetic fatty (ZDF) rats and its associations with systemic metaflammation. METHODS: Five-week-old ZDF rats and Zucker lean (ZL) rats were fed a high-fat diet (HFD) for 18 weeks. A baseline BOLD-MRI scan of perirenal adipose tissue was performed after 8 weeks of HFD feeding, and then the rats were randomized to receive pioglitazone or a vehicle for the following 10 weeks...
May 7, 2018: Obesity
https://www.readbyqxmd.com/read/29732718/impact-of-treatment-with-pioglitazone-on-stroke-outcomes-a-real-world-database-analysis
#10
Christopher Ll Morgan, Silvio E Inzucchi, Jorge Puelles, Sara Jenkins-Jones, Craig J Currie
AIMS: Randomised controlled trials have reported an association between pioglitazone and reduced incidence of stroke in type 2 diabetic (T2DM) and insulin-resistant populations. We investigated this association within a real-world database. MATERIALS AND METHODS: T2DM patients initiating pioglitazone between 2000-2012 were extracted from the Clinical Practice Research Datalink (CPRD); a UK routine. Two non-exposed control cohorts were matched on age, gender, HbA1c, diabetes duration, stroke history, co-morbidities and prior T2DM regimen...
May 7, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29731435/ethanolic-seeds-extract-of-centratherum-anthelminticum-reduces-oxidative-stress-in-type-2-diabetes
#11
Hina Akram Mudassir, Shamim Akhter Qureshi, Muhammad Bilal Azmi, Muhammad Ahsan
This work was accomplished to assess the in-vitro antiglycation and antioxidant activities of ethanolic seeds extract of Centratherum anthelminticum (CSEt), followed by its in-vivo examination in type 2 diabetes. Overnight fasted rabbits were divided into control and diabetic groups. Rabbits in diabetic group were fed with 35% fructose solution to develop hyperglycemia that was well-monitored by glucometer. These were divided into diabetic control (distilled water 1ml/kg), positive control group (pioglitazone 15mg/kg) and two test groups (CSEt 400 and 600mg treated)...
May 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29731242/therapeutic-effects-of-the-allosteric-protein-tyrosine-phosphatase-1b-inhibitor-ky-226-on-experimental-diabetes-and-obesity-via-enhancements-in-insulin-and-leptin-signaling-in-mice
#12
Yuma Ito, Masaki Fukui, Mamoru Kanda, Ko Morishita, Yoshimichi Shoji, Tatsuya Kitao, Eiichi Hinoi, Hiroaki Shirahase
The anti-diabetic and anti-obesity effects of the allosteric protein tyrosine phosphatase 1B (PTP1B) inhibitor 4-(biphenyl-4-ylmethylsulfanylmethyl)-N-(hexane-1-sulfonyl)benzoylamide (KY-226) were pharmacologically evaluated. KY-226 inhibited human PTP1B activity (IC50  = 0.28 μM), but did not exhibit peroxisome proliferator-activated receptor γ (PPARγ) agonist activity. In rodent preadipocytes (3T3-L1), KY-226 up to 10 μM had no effects on adipocyte differentiation, whereas pioglitazone, a PPARγ agonist, markedly promoted it...
March 6, 2018: Journal of Pharmacological Sciences
https://www.readbyqxmd.com/read/29727638/additive-effects-of-evogliptin-in-combination-with-pioglitazone-on-fasting-glucose-control-through-direct-and-indirect-hepatic-effects-in-diabetic-mice
#13
Tae-Hyoung Kim, Jeong-Ha Lee, Yu Na Chae, Il-Hoon Jung, Mi-Kyung Kim
Due to very limited preclinical reports, pharmacodynamic interactions between dipeptidyl peptidase 4 (DPP4) inhibitors and peroxisome proliferator-activated receptor γ (PPARγ) agonists are not conclusive yet. This study aimed to evaluate the pharmacological responses from adding evogliptin, a DPP4 inhibitor, to pioglitazone, a PPARγ agonist, in diabetic db/db mice after a 2-week treatment. This combination led to further decrease in both fasting and fed blood glucose levels compared to evogliptin alone (P < 0...
May 1, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29716851/effect-of-pioglitazone-on-vasopressor-responses-to-adrenergic-agonists-and-angiotensin-ii-in-diabetic-and-non-diabetic-spontaneously-hypertensive-rats
#14
Sheryar Afzal, Munavvar Abdul Sattar, Safia Akhtar, Nor Azizan Binti Abdullah, Olorunfemi A Eseyin, Mohammed H Abdulla, Edward James Johns
Pioglitazone, peroxisome proliferator-activated receptor (PPAR-γ) agonist, is a therapeutic drug for diabetes. Present study investigated the interaction between PPAR-γ and alpha adrenoceptors in modulating vasopressor responses to Angiotensin II (Ang II) and adrenergic agonists, in diabetic & non-diabetic Spontaneously Hypertensive Rats (SHRs). Diabetes was induced with an i.p injection of streptozotocin (40 mg/kg) in two groups (STZ-CON, STZ-PIO), whereas two groups remained non diabetic (ND-CO, ND-PIO)...
May 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29715453/role-of-wnt4-%C3%AE-catenin-ang-ii-tgf%C3%AE-ace2-nf-%C3%AE%C2%BAb-and-il-18-in-attenuating-renal-ischemia-reperfusion-induced-injury-in-rats-treated-with-vit-d-and-pioglitazone
#15
Rabab M Ali, Muhammad Y Al-Shorbagy, Maged W Helmy, Hanan S El-Abhar
Renal ischemia-reperfusion injury (I/RI) remains a critical clinical situation. Several evidence revealed the potential reno-protective effects of Vitamin D and/or pioglitazone, on renal I/RI. This study addresses the possible involvement of the Wnt4/β-catenin signaling, p-S536NF-κBp65, PPARγ, Ang II/TGF-β, and ACE2 as potential effectors to vitamin D and pioglitazone-mediated renoprotective effects. Two sets of Sprague-Dawley rats (n=30 rat each), were randomized into sham, I/R, Vit D "alfacalcidol" (5ng/kg/day), pioglitazone (5mg/kg/day), and Vit D + pioglitazone groups...
April 28, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29712716/regulation-of-the-metabolism-of-apolipoprotein-m-and-sphingosine-1-phosphate-by-hepatic-ppar%C3%AE-activity
#16
Makoto Kurano, Hitoshi Ikeda, Naoyuki Iso-O, Masumi Hara, Kazuhisa Tsukamoto, Yutaka Yatomi
Apolipoprotein M (apoM) is a carrier and a modulator of sphingosine 1-phosphate (S1P), an important multi-functional bioactive lipid. Since PPARγ is reportedly associated with the function and metabolism of S1P, we investigated the modulation of apoM/S1P homeostasis by PPARγ. First, we investigated the modulation of apoM and S1P homeostasis by the overexpression or knockdown of PPARγ in HepG2 cells and found that both the overexpression and the knockdown of PPARγ decreased apoM expression and S1P synthesis...
April 30, 2018: Biochemical Journal
https://www.readbyqxmd.com/read/29712510/modulation-of-brain-insulin-signaling-in-alzheimer-s-disease-new-insight-on-the-protective-role-of-green-coffee-bean-extract
#17
Hoda E Mohamed, Mervat E Asker, Nahla N Younis, Mohamed A Shaheen, Rana G Eissa
OBJECTIVE: Alzheimer's disease (AD), a neurodegenerative disorder, involves brain insulin signaling cascades and insulin resistance (IR). Because of limited treatment options, new treatment strategies are mandatory. Green coffee bean extract (GCBE) was reported to attenuate IR and improve brain energy metabolism. We aimed to investigate the possible use of GCBE as a prophylactic strategy to delay the onset of AD or combined with pioglitazone (PIO) as a strategy to retard the progression of AD...
May 1, 2018: Nutritional Neuroscience
https://www.readbyqxmd.com/read/29706617/effect-of-hexadecyl-azelaoyl-phosphatidylcholine-on-cardiomyocyte-apoptosis-in-myocardial-ischemia-reperfusion-injury-a-hypothesis
#18
Limin Feng, Wennan Liu, Jianzhou Yang, Qing Wang, Shiwu Wen
Reperfusion after myocardial ischemia can induce cardiomyocyte death, known as myocardial reperfusion injury. The pathophysiology of the process of reperfusion suggests the confluence multiple pathways. Recent studies have focused on the inflammatory response, which is considered to be the main mechanism during the process of myocardial ischemia-reperfusion injury and can cause cardiomyocyte apoptosis. Peroxisome proliferator-activated receptors gamma activated by endogenous ligands and exogenous ligand can decrease the inflammatory response in cardiomyocytes...
April 30, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29695452/ppar%C3%AE-agonist-pioglitazone-reverses-pulmonary-hypertension-and-prevents-right-heart-failure-via-fatty-acid-oxidation
#19
Ekaterina Legchenko, Philippe Chouvarine, Paul Borchert, Angeles Fernandez-Gonzalez, Erin Snay, Martin Meier, Lavinia Maegel, S Alex Mitsialis, Eva A Rog-Zielinska, Stella Kourembanas, Danny Jonigk, Georg Hansmann
Right ventricular (RV) heart failure is the leading cause of death in pulmonary arterial hypertension (PAH). Peroxisome proliferator-activated receptor γ (PPARγ) acts as a vasoprotective metabolic regulator in smooth muscle and endothelial cells; however, its role in the heart is unclear. We report that deletion of PPARγ in cardiomyocytes leads to biventricular systolic dysfunction and intramyocellular lipid accumulation in mice. In the SU5416/hypoxia (SuHx) rat model, oral treatment with the PPARγ agonist pioglitazone completely reverses severe PAH and vascular remodeling and prevents RV failure...
April 25, 2018: Science Translational Medicine
https://www.readbyqxmd.com/read/29683100/pioglitazone-therapy-and-fractures-systematic-review-and-meta-analysis
#20
Velichka Pavlova, Elena Filipova, Katya Uzunova, Krassimir Kalinov, Toni Vekov
INTRODUCTION: Thiazolidinediones are group of synthetic medications used in type 2 diabetes treatment. Among available thiazolidinediones pioglitazone is gaining increased attention due to its lower cardiovascular risk in type 2 diabetes mellitus sufferers and seems a promising future therapy. Accumulating evidence suggests that diabetic patients may exert bone fractures due to such treatments. Simultaneously, female population is thought to be at greater risk. Still the safety outcomes of pioglitazone treatment especially in terms of fractures are questionable and need to be clarified...
April 23, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
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