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https://www.readbyqxmd.com/read/28428238/complement-and-clot
#1
Vahid Afshar-Kharghan
No abstract text is available yet for this article.
April 20, 2017: Blood
https://www.readbyqxmd.com/read/28426392/design-and-validation-of-a-new-method-to-detect-and-quantify-residual-host-cell-dna-in-human-recombinant-erythropoietin-repo
#2
Shima Zamanian, Samira Mohammadi-Yeganeh, Vahid Kia, Hooman Kaghazian, Mahdi Paryan
During the purification of Human Recombinant EPO (rEPO) from host cells, residual DNA may remain in final products. This contamination is a risk factor for patients and may result in the inactivation of some tumor suppressor genes (TSG) or activation of oncogenes if its concentration is more than the standard defined by WHO. Based on WHO's criteria, acceptable level of residual DNA in biopharmaceuticals is less than 10-100 picograms/dose. In this study we have designed a sensitive and specific Quantitative Real-time PCR assay for detection of residual DNA in human rEPO products...
April 20, 2017: Preparative Biochemistry & Biotechnology
https://www.readbyqxmd.com/read/28425863/targeted-drug-delivery-based-on-gold-nanoparticle-derivatives
#3
Mazaher Gholipourmalekabadi, Mohammadmahdi Mobaraki, Maryam Ghaffari, Amir Zarebkohan, Vahid F Omrani, Aleksandra M Urbanska, Alexander Seifalian
Drug delivery systems are effective and attractive methods which allow therapeutic substances to be introduced into the body more effectively and safe by having tunable delivery rate and release target site. Gold nanoparticles (AuNPs) have a myriad of favorable physical, chemical, optical, thermal and biological properties that make them highly suitable candidates as non-toxic carriers for drug and gene delivery. The surface modifications of AuNPs profoundly improve their circulation, minimize aggregation rates, enhance attachment to therapeutic molecules and target agents due to their nano range size which further increases their ability to cross cell membranes and reduce overall cytotoxicity...
April 19, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28423950/hepatoprotective-and-free-radical-scavenging-actions-of-quercetin-nanoparticles-on-a%C3%AF-atoxin-b1-induced-liver-damage-in-vitro-in-vivo-studies
#4
Aziz Eftekhari, Elham Ahmadian, Vahid Panahi-Azar, Hedayat Hosseini, Mahnaz Tabibiazar, Solmaz Maleki Dizaj
The objective of present study was in vitro and in vivo evaluation of hepatoprotective and antioxidant activity of Quercetin nanoparticles (Q NPs) against toxicity induced by aflatoxin B1. The Q NPs were prepared using precipitation method. Hepatocytes were prepared by the method of collagenase enzyme perfusion via portal vein. The NPs were characterized in terms of size and morphology using dynamic light scattering (DLS) and transmission electron microscopy (TEM), respectively. The level of parameters, such as cell death, ROS formation, lipid peroxidation, mitochondrial membrane potential and cellular glutathione (GSH) content, in the aflatoxin B1-treated and non-treated hepatocytes were determined and the mentioned markers were assessed in the presence of Q NPs...
April 20, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28422264/rhodium-catalyzed-addition-of-sulfonyl-hydrazides-to-allenes-regioselective-synthesis-of-branched-allylic-sulfones
#5
Vahid Khakyzadeh, Yu-Hsuan Wang, Bernhard Breit
A rhodium-catalyzed regioselective addition of sulfonyl hydrazides to allenes is reported. With Rh(i)/DPEphos/benzoic acid as the catalyst system, branched allylic sulfones can be obtained, in good to excellent yields and regioselectivities.
April 19, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28418507/use-of-bayesian-decision-analysis-to-minimize-harm-in-patient-centered-randomized-clinical-trials-in-oncology
#6
Vahid Montazerhodjat, Shomesh E Chaudhuri, Daniel J Sargent, Andrew W Lo
Importance: Randomized clinical trials (RCTs) currently apply the same statistical threshold of alpha = 2.5% for controlling for false-positive results or type 1 error, regardless of the burden of disease or patient preferences. Is there an objective and systematic framework for designing RCTs that incorporates these considerations on a case-by-case basis? Objective: To apply Bayesian decision analysis (BDA) to cancer therapeutics to choose an alpha and sample size that minimize the potential harm to current and future patients under both null and alternative hypotheses...
April 13, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28415516/acceleration-of-bone-regeneration-in-bioactive-glass-gelatin-composite-scaffolds-seeded-with-bone-marrow-derived-mesenchymal-stem-cells-over-expressing-bone-morphogenetic-protein-7
#7
Saeid Kargozar, Seyed Jafar Hashemian, Mansooreh Soleimani, Peiman Brouki Milan, Mohammad Askari, Vahid Khalaj, Ali Samadikuchaksaraie, Sepideh Hamzehlou, Amir Reza Katebi, Noorahmad Latifi, Masoud Mozafari, Francesco Baino
In this research, the osteoinduction effect of a novel variant of bone morphogenetic protein-7 (BMP-7), delivered through bone marrow mesenchymal stem cells (BM-MSCs) seeded on bioactive glass/gelatin nanocomposite scaffolds, was evaluated in a calvarial critical size defect in rats. After being harvested and characterized in vitro, BM-MSCs were infected by a plasmid vector containing BMP-7 encoding gene enriched with a heparin-binding site (B2BMP-7) to assess its osteogenic effects in vivo. The animals were randomly categorized into three groups receiving the scaffold alone (group I), the scaffold seeded with BM-MSCs (group II), and the scaffold seeded with manipulated BM-MSCs (group III)...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28415460/poly-arginine-graphene-quantum-dots-as-a-biocompatible-and-non-toxic-nanocomposite-layer-by-layer-electrochemical-preparation-characterization-and-non-invasive-malondialdehyde-sensory-application-in-exhaled-breath-condensate
#8
Mohammad Hasanzadeh, Fozieh Mokhtari, Nasrin Shadjou, Aziz Eftekhari, Ahad Mokhtarzadeh, Vahid Jouyban-Gharamaleki, Soltanali Mahboob
This study reports on the electropolymerization of a low toxic and biocompatible polymer with entitle poly arginine-graphene quantum dots (PARG-GQDs) as a novel strategy for surface modification of glassy carbon (GC) surface and preparation a new interface for biomedical application. The fabrication of PARG-GQDs on GCE was performed using Layer-by-layer regime. Scanning electron microscopy (SEM) was confirmed dispersion of GQDs on the surface of PARG which lead to increase of surface coverage of PARG. The redox behavior of prepared sensor was then characterized by cyclic voltammetry (CV), differential pulse voltammetry (DPV) and chronoamperometry (CHA), square wave voltammetry (SWV), linear sweep voltammetry (LSV)...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28414112/binding-of-erucic-acid-with-human-serum-albumin-using-a-spectroscopic-and-molecular-docking-study
#9
Gulam Rabbani, Mohammad Hassan Baig, Arif Tasleem Jan, Eun Ju Lee, Mohsin Vahid Khan, Masihuz Zaman, Abd-ElAziem Farouk Gad, Rizwan Hasan Khan, Inho Choi
Erucic acid (EA) is one of the key fatty acids usually found in canola oil, mustard oil and rapeseed oil. Consumption of EA in primates was found to cause myocardial lipidosis and cardiac steatosis. To have an insight of the effect of EA in humans, we performed in vitro interaction studies of EA with the primary plasma protein, human serum albumin (HSA). Spectroscopic (UV-vis and fluorescence) analysis of the EA-HSA interaction revealed a static mode of quenching, with binding constant Kb ∼10(4) reflecting high affinity of EA for HSA...
April 13, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28412168/facilitating-translational-nanomedicine-via-predictive-safety-assessment
#10
REVIEW
Vahid Mirshafiee, Wen Jiang, Bingbing Sun, Xiang Wang, Tian Xia
Extensive research on engineered nanomaterials (ENMs) has led to the development of numerous nano-based formulations for theranostic purposes. Although some nano-based drug delivery systems already exist on the market, growing numbers of newly designed ENMs exhibit improved physicochemical properties and are being assessed in preclinical stages. While these ENMs are designed to improve the efficacy of current nano-based therapeutic or imaging systems, it is necessary to thoroughly determine their safety profiles for successful clinical applications...
April 13, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/28409897/boosting-the-lifetime-and-enhancing-the-efficiency-of-organic-solar-cell-by-applying-an-in-situ-synthesized-low-crystalline-amorphous-zno-layer-as-a-high-potential-buffer-layer
#11
Farzaneh Arabpour Roghabadi, Vahid Ahmadi, Bahram Abdollahi Nejand, Karim Oniy Aghmiuni
By introducing an in situ-synthesized low-crystalline ZnO (LC-ZnO) (amorphous) layer between the cathode and the active layer of PCPDTBT: CdSe solar cell, the device keeps more than 80% and 40% of its initial lifetime after 180 days and 360 days without any encapsulation, respectively. In this regard, 180 days is the highest lifetime achieved for polymer-based solar cells with direct configuration. In addition, the power conversion efficiency (PCE) is improved up to 70% in the presence of the LC-ZnO interfacial layer...
April 14, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28408290/automated-template-based-brain-localization-and-extraction-for-fetal-brain-mri-reconstruction
#12
Sébastien Tourbier, Clemente Velasco-Annis, Vahid Taimouri, Patric Hagmann, Reto Meuli, Simon K Warfield, Meritxell Bach Cuadra, Ali Gholipour
Most fetal brain MRI reconstruction algorithms rely only on brain tissue-relevant voxels of low-resolution (LR) images to enhance the quality of inter-slice motion correction and image reconstruction. Consequently the fetal brain needs to be localized and extracted as a first step, which is usually a laborious and time consuming manual or semi-automatic task. We have proposed in this work to use age-matched template images as prior knowledge to automatize brain localization and extraction. This has been achieved through a novel automatic brain localization and extraction method based on robust template-to-slice block matching and deformable slice-to-template registration...
April 10, 2017: NeuroImage
https://www.readbyqxmd.com/read/28402208/a-dynamic-approach-for-outpatient-scheduling
#13
James Creps, Vahid Lotfi
AIMS: Patient no-show is a recurrent problem in medical centers and, in conjunction with cancellation of appointments, often results in loss of productivity and excessive patient time to appointment. The purpose of this study was to develop a dynamic procedure for scheduling patients within an outpatient clinic where patients are expected to have multiple appointments, such as physical therapy, occupational therapy, primary care, and dentistry. METHODS: This retrospective study involved the year 2014 de-identified patient records from an outpatient clinic affiliated with a large university hospital...
April 12, 2017: Journal of Medical Economics
https://www.readbyqxmd.com/read/28401106/jak2-exon-12-mutation-positive-myeloproliferative-neoplasm-associated-with-recurrent-thromboembolism
#14
Vahid Tavakoli, Sundee Naing
No abstract text is available yet for this article.
March 2017: Blood Research
https://www.readbyqxmd.com/read/28400832/the-psychometric-properties-of-the-persian-version-of-interpersonal-sensitivity-measure
#15
Youkhabeh Mohammadian, Behzad Mahaki, Fahimeh Fathali Lavasani, Mahmoud Dehghani, Mohammadkazem Atef Vahid
BACKGROUND: Investigating the psychometric properties of existing psychometric scales in societies with differing dynamics can help with their external validity. This research specifically aimed at standardization and validation of Interpersonal Sensitivity Measure (IPSM) scale in Iran. MATERIALS AND METHODS: Persian version of the IPSM was produced through forward translation, reconciliation, and back translation. A total of 357, nonclinical students were selected through multistage sampling method and completed a set of questionnaires including IPSM...
2017: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/28399705/biophysical-insight-reveals-tannic-acid-as-amyloid-inducer-and-conformation-transformer-from-amorphous-to-amyloid-aggregates-in-concanavalin-a-cona
#16
Mohsin Vahid Khan, Mohd Ishtikhar, Mohammad Khursheed Siddiqui, Masihuz Zaman, Tajalli Ilm Chandel, Nabeela Majid, Mohd Rehan Ajmal, Ali Saber Abdelhameed, Yasser E Shahein, Rizwan Hasan Khan
The aggregation phenomenon (amyloid and amorphous) is associated with several pathological complications in human, such as Alzheimer's, Parkinson's, Huntington, Cataract diseases and Diabetes mellitus type 2. In the present study we are offering evidence and breaking the general belief with regard to the polyphenols action as protein aggregate inhibitors. Herein we confirm that tannic acid (TA) is not only an amyloid inducer, but also it switches one type of conformation, ultimately morphology, into another...
April 11, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/28397453/the-effect-of-curing-light-intensity-on-free-volume-size-in-some-dental-composites
#17
Mahdieh Shirazinia, Ali Akbar Mehmandoost-Khajeh-Dad, Vahid Dehghani, Jamshid Mehmandoost-Khajeh-Dad, Morteza Khaghani
BACKGROUND: Dental composite resins - reinforced polymers - are types of synthetic resins that are used in dentistry as restorative material or adhesives. The effect of curing-light intensity on free volume sizes of 4 commercial dental composites has been studied by means of the well-known positron annihilation lifetime spectroscopy technique. OBJECTIVES: The aim of the study was to compare the photosensitivity of 4 commercial dimethacrylate-based dental composites...
July 2016: Polimery W Medycynie
https://www.readbyqxmd.com/read/28394606/is-the-solution-activity-derivative-sufficient-to-parameterize-ion-ion-interactions-in-aqueous-solution-ions-for-tip5p-water
#18
Vahid Satarifard, Sadra Kashefolgheta, Ana Vila Verde, Andrea Grafmueller
Biomolecular processes involve hydrated ions, and thus molecular simulations of such processes require accurate force-field parameters for these ions. In the best force-fields, both ion-water and anion-cation interactions are explicitly parameterized. First, the ion Lennard-Jones parameters are optimized to reproduce, e.g., single ion solvation free energies; then ion-pair interactions are often adjusted to match experimental activity or activity derivatives. Here we apply this approach to derive optimized parameters for concentrated NaCl, KCl, MgCl2 and CaCl2 salt solutions, to be used with the TIP5P water model...
April 10, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28393053/the-effect-of-topical-tranexamic-acid-on-bleeding-reduction-during-functional-endoscopic-sinus-surgery
#19
Mohammad Hossein Baradaranfar, Mohammad Hossein Dadgarnia, Hossein Mahmoudi, Nasim Behniafard, Saeid Atighechi, Vahid Zand, Amin Baradaranfar, Sedighe Vaziribozorg
INTRODUCTION: Bleeding is a common concern during functional endoscopic sinus surgery (FESS) that can increase the risk of damage to adjacent vital elements by reducing the surgeon's field of view. This study aimed to explore the efficacy of topical tranexamic acid in reducing intraoperative bleeding. MATERIALS AND METHODS: This double-blind, randomized clinical trial was conducted in 60 patients with chronic rhinosinusitis with polyposis (CRSwP) who underwent FESS...
March 2017: Iranian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/28392894/anti-melanogenic-activity-of-viola-odorata-different-extracts-on-b16f10-murine-melanoma-cells
#20
Vafa Baradaran Rahimi, Vahid Reza Askari, Seyed Ahmad Emami, Zahra Tayarani-Najaran
OBJECTIVES: In previous studies, antioxidant activity of Viola odorata L. has been demonstrated. In this study, we have investigated the anti-melanogenic effect of extract and fractions of the plant in B16F10 cell line. MATERIALS AND METHODS: Impact of different increasing concentrations of extract and fractions of V. odorata was evaluated on cell viability, cellular tyrosinase, melanin content and mushroom tyrosinase as well as ROS production in B16F10 murine melanoma cell line...
March 2017: Iranian Journal of Basic Medical Sciences
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