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https://www.readbyqxmd.com/read/28632492/is-the-location-of-the-signal-intensity-weighted-centroid-a-reliable-measurement-of-fluid-displacement-within-the-disc
#1
Vahid Abdollah, Eric C Parent, Michele C Battié
Degenerated discs have shorter T2-relaxation time and lower MR signal. The location of the signal-intensity-weighted-centroid reflects the water distribution within a region-of-interest (ROI). This study compared the reliability of the location of the signal-intensity-weighted-centroid to mean signal intensity and area measurements. L4-L5 and L5-S1 discs were measured on 43 mid-sagittal T2-weighted 3T MRI images in adults with back pain. One rater analysed images twice and another once, blinded to measurements...
June 20, 2017: Biomedizinische Technik. Biomedical Engineering
https://www.readbyqxmd.com/read/28632076/association-of-oprd1-gene-variants-with-opioid-dependence-in-addicted-male-individuals-undergoing-methadone-treatment-in-the-north-of-iran
#2
Alireza Sharafshah, Hedyeh Fazel, Ali Albonaim, Vahid Omarmeli, Sajjad Rezaei, Ebrahim Mirzajani, Farzam Ajamian, Parvaneh Keshavarz
Genetic association of rs678849 along with neuroimaging and biomarker phenotypes, parallel with the known involvements of the OPRD1 in drug abuse, provided additional support for targeting these receptors as potential therapeutic targets in both neurodegenerative diseases and neuropsychiactric disorders such as Alzheimer's disease. Samples were selected among 202 opium-addicted participants undergoing methadone treatment and 202 healthy controls. Genomic DNA of all subjects was extracted from whole blood samples through a Salting Out procedure...
March 1, 2017: Journal of Psychoactive Drugs
https://www.readbyqxmd.com/read/28626825/phace-s-syndrome-report-of-a-case-with-new-ocular-and-systemic-manifestations
#3
Raheleh Assari, Vahid Ziaee, Sasan Moghimi, Mohammad Reza Akbari, Arash Mirmohammadsadeghi
PURPOSE: To describe an infant with PHACE(S) syndrome [posterior fossa anomalies (P), hemangiomas (H), arterial anomalies (A), cardiac abnormalities and coarctation of aorta (C), eye abnormalities (E), and the sternal defects (S)] with unusual strabismus, congenital glaucoma, and new systemic manifestations. METHODS: A 6-month-old girl was referred with large hemangiomas on the left side of the face. RESULTS: In the ocular examination, right esotropia and hypotropia, and limitation of elevation in adduction in the right eye were seen...
June 2017: Journal of Current Ophthalmology
https://www.readbyqxmd.com/read/28623529/ameliorative-effect-of-omega-3-on-spermatogenesis-testicular-antioxidant-status-and-preimplantation-embryo-development-in-streptozotocin-induced-diabetes-in-rats
#4
Mehdi Khavarimehr, Vahid Nejati, Mazdak Razi, Gholamreza Najafi
PURPOSE: The present study was done to determine the ameliorative effect of polyunsaturated fatty acid omega-3 against experimental diabetes-induced damages on testicular tissue, sperm parameters and preimplantation embryo development in rat model. METHODS: Thirty-two mature male rats were divided into two control and test groups. The experimental diabetes (50 mg kg(-1) streptozotocin, ip) was induced in test group and subdivided into non-treated diabetic, 300 and 600 mg kg(-1) omega-3-treated (orally by gavage) groups...
June 16, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28623507/physiological-characteristics-of-plantago-major-under-so2-exposure-as-affected-by-foliar-iron-spray
#5
Vahid Mohasseli, Amir Hossein Khoshgoftarmanesh, Hossein Shariatmadari
Sulfur dioxide (SO2) is considered as a main air pollutant in industrialized areas that can damage vegetation. In the present study, we investigated how exposure to SO2 and foliar application of iron (Fe) would affect certain physiological characteristics of Plantago major. The plant seedlings exposed or unexposed to SO2 (3900 μg m(-3)) were non-supplemented or supplemented with Fe (3 g L(-1)) as foliar spray. Plants were exposed to SO2 for 6 weeks in 100 × 70 × 70 cm chambers. Fumigation of plants with SO2 was performed for 3 h daily for 3 days per week (alternate day)...
June 17, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28622710/effect-of-intravenous-immunoglobulin-on-th1-and-th2-lymphocytes-and-improvement-of-pregnancy-outcome-in-recurrent-pregnancy-loss-rpl
#6
Majid Ahmadi, Samaneh Abdolmohammadi-Vahid, Mahnaz Ghaebi, Leili Aghebati-Maleki, Amir Afkham, Shahla Danaii, Sedigheh Abdollahi-Fard, Lida Heidari, Farhad Jadidi-Niaragh, Vahid Younesi, Mohammad Nouri, Mehdi Yousefi
BACKGROUND: Women with elevated natural killer (NK) cell frequency and function during pregnancy, suffer from recurrent pregnancy loss (RPL). In the present study, the possible effect of intravenous immunoglobulin (IVIG) administration on Th1 and Th2 cell frequency, cytokine secretion, and expression of transcription factors is compared between RPL patients and control group. MATERIALS AND METHODS: Totally, 44 women with a history of RPL (32 women as treated group and 12 as control group) were enrolled in the study...
June 12, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28620935/fast-precision-estimation-in-high-dimensional-multivariate-joint-models
#7
Vahid Nassiri, Anna Ivanova, Geert Molenberghs, Geert Verbeke
A fast way is proposed based on the multiple outputation idea (Hoffman et al., ; Follmann et al., ) to calculate the precision of parameter estimates for high-dimensional multivariate joint models using a pairwise approach (Fieuws and Verbeke, ; Fieuws et al., ). Simulation results as well as data analysis shows possibly more than 2500 times faster computations using the proposed method. In our real data illustration, the time gain is more than 330 times.
June 16, 2017: Biometrical Journal. Biometrische Zeitschrift
https://www.readbyqxmd.com/read/28618654/comparison-of-honey-and-dextrose-solution-on-post-operative-peritoneal-adhesion-in-rat-model
#8
Vafa Baradaran Rahimi, Reza Shirazinia, Narges Fereydouni, Parvin Zamani, Sousan Darroudi, Amir Hossein Sahebkar, Vahid Reza Askari
BACKGROUND: Peritoneal adhesion between abdominal organs is a complication of surgery. It causes major complications like pain, bowel obstruction, infertility and increases risk of death. Honey is known to have anti-inflammatory and antioxidant properties potentially relevant for adhesive protection. METHODS: Thirty rats were divided into five groups: negative control without any surgical procedure (normal group), control group treated with normal saline, experimental group I treated with 1ml of 10% honey, experimental group II treated with honey at half concentration of group I (honey0...
June 10, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28611202/role-of-platelet-derived-tgf%C3%AE-1-in-the-progression-of-ovarian-cancer
#9
Qianghua Hu, Takeshi Hisamatsu, Monika Hammerle, Min Soon Cho, Sunila Pradeep, Rajesha Rupaimoole, Cristian Rodriguez-Aguayo, Gabriel Lopez-Berestein, Stephen Tc Wong, Anil K Sood, Vahid Afshar-Kharghan
Transforming growth factor β1 (Tgfß1) plays an important role in cancer.  Most of Tgfß1 in plasma is from platelets, thus we studied whether platelet Tgfß1 has any role in the progression of ovarian cancer, and whether this role is limited to metastasis or also involves the growth of primary tumors. <br /><br />Experimental Design: We compared the growth of murine ovarian cancer cell-induced tumors in platelet-specific Tgfß1 deficient mice and wild-type mice.  Using resected tumor nodules, we studied the effect of platelet Tgfß1 on neoangiogenesis and on platelet extravasation into tumors...
June 13, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28606051/comparison-of-bone-mineral-density-in-common-variable-immunodeficiency-and-x-linked-agammaglobulinaemia-patients
#10
Ali Mohebbi, Gholamreza Azizi, Naeimeh Tavakolinia, Mehdi Karimipour, Fatemeh Kiaee, Reza Yazdani, Sareh Sadat Ebrahimi, Hosein Rafiemanesh, Vahid Ziaee, Hassan Abolhassani, Asghar Aghamohammadi, Farzaneh Abbasi, Fatemeh Sayarifard, Mehran Ebrahimi, Javad Tafaroji
BACKGROUND: Primary antibody deficiency (PAD) is the most common group of primary immunodeficiency disorders, resulting from different defects in development and function of B cell lineage. Common variable immunodeficiency (CVID) and X-linked agammaglobulinemia (XLA) are two of the major types of PADs. Optimal growth and subsequently bone health could potentially compromise due to the interference of several factors in PAD with childhood onset. In the present study, our aim was to evaluate bone mineral density (BMD) of patients with CVID and XLA...
June 11, 2017: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/28605290/early-response-based-therapy-stratification-improves-survival-in-adult-early-thymic-precursor-acute-lymphoblastic-leukemia-a-group-for-research-on-adult-acute-lymphoblastic-leukemia-study
#11
Jonathan Bond, Carlos Graux, Ludovic Lhermitte, Diane Lara, Thomas Cluzeau, Thibaut Leguay, Agata Cieslak, Amélie Trinquand, Cedric Pastoret, Mohamed Belhocine, Salvatore Spicuglia, Véronique Lheritier, Stéphane Leprêtre, Xavier Thomas, Françoise Huguet, Norbert Ifrah, Hervé Dombret, Elizabeth Macintyre, Nicolas Boissel, Vahid Asnafi
Purpose Early thymic precursor (ETP) acute lymphoblastic leukemia (ALL) is an immunophenotypically defined subgroup of T-cell ALL (T-ALL) associated with high rates of intrinsic treatment resistance. Studies in children have shown that the negative prognostic impact of chemotherapy resistance is abrogated by the implementation of early response-based intensification strategies. Comparable data in adults are lacking. Patients and Methods We performed comprehensive clinicobiologic, genetic, and survival analyses of a large cohort of 213 adult patients with T-ALL, including 47 patients with ETP-ALL, treated in the GRAALL (Group for Research on Adult Acute Lymphoblastic Leukemia) -2003 and -2005 studies...
June 12, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28602483/a-hybrid-framework-for-reverse-engineering-of-robust-gene-regulatory-networks
#12
Mina Jafari, Behnam Ghavami, Vahid Sattari
The inference of Gene Regulatory Networks (GRNs) using gene expression data in order to detect the basic cellular processes is a key issue in biological systems. Inferring GRN correctly requires inferring predictor set accurately. In this paper, a fast and accurate predictor set inference framework which linearly combines some inference methods is proposed. The purpose of the combination of various methods is to increase the accuracy of inferred GRN. The proposed framework offers a linear weighted combination of Pearson Correlation Coefficient (PCC) and two different feature selection approaches, namely: Information Gain (IG) and ReliefF...
June 8, 2017: Artificial Intelligence in Medicine
https://www.readbyqxmd.com/read/28591301/a-grounded-theory-study-of-the-intention-of-nurses-to-leave-the-profession
#13
Leyla Alilu, Vahid Zamanzadeh, Leila Valizadeh, Hosein Habibzadeh, Mark Gillespie
Objective: this study explores the process of the development of an intention to leave bedside nursing. Method: the process was studied from the perspective of 21 nurses using the grounded theory method. Data were collected using semi-structured interviews and the constant comparative method of Corbin and Strauss was used for data analysis. Results: according to the participants, the two main categories, "social image of nursing", and "culture and structure of the bedside", were the contextual factors that influence why nurses are leaving bedside care provision...
June 5, 2017: Revista Latino-americana de Enfermagem
https://www.readbyqxmd.com/read/28590715/enhanced-immune-adjuvant-activity-of-aluminum-oxyhydroxide-nanorods-through-cationic-surface-functionalization
#14
Bingbing Sun, Zhaoxia Ji, Yu-Pei Liao, Chong Hyun Chang, Xiang Wang, Justine Ku, Changying Xue, Vahid Mirshafiee, Tian Xia
Aluminum salt-based vaccine adjuvants are prevailingly used in FDA-approved vaccines for the prevention of infectious diseases for over eight years. Despite of their safe applications, the mechanisms regarding how the material characteristics affect the interactions at nano-bio interface and immunogenicity still remain unclear. Recently, studies have indicated that NLRP3 inflammasome activation plays a critical role to induce adjuvant effects that is controlled by the inherent shape and hydroxyl contents of aluminum oxyhydroxide (AlOOH) nanoparticles, however, the detailed relationship between surface properties and adjuvant effects for these materials remain unknown...
June 7, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28590110/modeling-and-optimization-of-nldh-pvdf-ultrafiltration-nanocomposite-membrane-using-artificial-neural-network-genetic-algorithm-hybrid
#15
Samira Arefi-Oskoui, Alireza Khataee, Vahid Vatanpour
In this research, MgAl-CO32- nanolayered double hydroxide (NLDH) was synthesized through a facile co-precipitation method followed by a hydrothermal treatment. The prepared NLDHs were used as a hydrophilic nanofiller for improving the performance of the PVDF-based ultrafiltration membranes. The main objective of this research was to obtain the optimized formula of NLDH/PVDF nanocomposite membrane presenting the best performance using computational techniques as a cost-effective method. For this aim, an artificial neural network (ANN) model was developed for modeling and expressing the relationship between the performance of the nanocomposite (pure water flux, protein flux and flux recovery ratio) and the affecting parameters including the NLDH, PVP 29000 and polymer concentrations...
June 7, 2017: ACS Combinatorial Science
https://www.readbyqxmd.com/read/28589659/validity-and-reliability-of-abbreviated-mental-test-score-amts-among-older-iranian
#16
Mahshid Foroughan, Lars-Olof Wahlund, Zahra Jafari, Mehdi Rahgozar, Ida G Farahani, Vahid Rashedi
BACKGROUND: Cognitive impairment is common among older people and is associated with increased morbidity and mortality. The main aim of this study was to evaluate the validity of the Persian version of the Abbreviated Mental Test Score (AMTS) as a screening tool for dementia. METHODS: Data were obtained from a cross-sectional study. One hundred and one older adults who were members of Iranian Alzheimer Association and 101 of their siblings were entered into this study by convenient sampling...
June 6, 2017: Psychogeriatrics: the Official Journal of the Japanese Psychogeriatric Society
https://www.readbyqxmd.com/read/28585944/cellular-uptake-of-nanoparticles-journey-inside-the-cell
#17
REVIEW
Shahed Behzadi, Vahid Serpooshan, Wei Tao, Majd A Hamaly, Mahmoud Y Alkawareek, Erik C Dreaden, Dennis Brown, Alaaldin M Alkilany, Omid C Farokhzad, Morteza Mahmoudi
Nanoscale materials are increasingly found in consumer goods, electronics, and pharmaceuticals. While these particles interact with the body in myriad ways, their beneficial and/or deleterious effects ultimately arise from interactions at the cellular and subcellular level. Nanoparticles (NPs) can modulate cell fate, induce or prevent mutations, initiate cell-cell communication, and modulate cell structure in a manner dictated largely by phenomena at the nano-bio interface. Recent advances in chemical synthesis have yielded new nanoscale materials with precisely defined biochemical features, and emerging analytical techniques have shed light on nuanced and context-dependent nano-bio interactions within cells...
June 6, 2017: Chemical Society Reviews
https://www.readbyqxmd.com/read/28584790/ameliorative-effects-of-nilotinib-on-ccl4-induced-liver-fibrosis-via-attenuation-of-rage-hmgb1-gene-expression-and-oxidative-stress-in-rat
#18
Vahid Khanjarsim, Jamshid Karimi, Iraj Khodadadi, Adel Mohammadalipour, Mohammad Taghi Goodarzi, Ghasem Solgi, Mohammad Hashemnia
Nilotinib as a tyrosine kinase inhibitor has been recently used to improve the liver fibrosis process, but the exact mechanisms still require further clarification. In this study, we investigated the anti-fibrotic effects of Nilotinib via RAGE/HMGB1axis and antioxidant mechanisms. This experimental study was performed in the Hamadan University of Medical Sciences, Iran, from May 2015 to December 2016. Liver fibrosis was induced in Wistar male rats by CCL4. Rats were gavaged daily with Nilotinib (10 mg/kg). RAGE, HMGB1, TNF-α and TGF-β mRNA expression were evaluated by quantitative RT-PCR...
May 2017: Chonnam Medical Journal
https://www.readbyqxmd.com/read/28584644/evaluation-of-tumor-necrosis-factor-tnf-%C3%AE-mrna-expression-level-and-the-rs1799964-polymorphism-of-the-tnf-%C3%AE-gene-in-peripheral-mononuclear-cells-of-patients-with-inflammatory-bowel-diseases
#19
Mahyar Nourian, Vahid Chaleshi, Leila Pishkar, Pedram Azimzadeh, Shaghayegh Baradaran Ghavami, Hedieh Balaii, Samaneh Alinaghi, Shabnam Shahrokh, Hamid Asadzadeh Aghdaei, Mohammad Reza Zali
Crohn's disease (CD) and ulcerative colitis (UC) are types of chronic inflammatory bowel disease (IBD) of which the actual causes remain unknown. Emerging data indicate that alterations in cytokine synthesis may be involved in IBD pathogenesis. The aim of the present study was to determine whether the tumor necrosis factor (TNF)-α mRNA expression level and rs1799964 polymorphism are the genetic susceptibility component of IBD development. The TNF-α mRNA expression level of peripheral blood mononuclear cells (PBMCs) was measured using comparative reverse-transcription quantitative polymerase chain reaction (PCR)...
June 2017: Biomedical Reports
https://www.readbyqxmd.com/read/28584539/correlation-between-chronological-age-and-third-molar-developmental-stages-in-an-iranian-population-demirjian-method
#20
Aria Khosronejad, Manijeh Navabi, Shirin Sakhdari, Vahid Rakhshan
BACKGROUND: Third molar development is the only available tool for estimating the age of individuals after puberty. Since this tooth has very high interethnic variability, formulas calculated to estimate the age from its development stages cannot be generalized to other populations and should be adjusted for each region. Therefore, this study was conducted to evaluate this method in a sample of Tehran individuals for the first time, and also to compare the development of third molars across sexes and arches, and to estimate cutoff developmental stages for legal minor/major identification...
March 2017: Dental Research Journal
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