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Peyman Zamani, Zahra Soleymani, Vahid Rashedi, Farhad Farahani, Gohar Lotf, Mohammad Rezaei
Objectives: To compare narrative skills between fourth and fifth grades of Persian-speaking students with hearing impairments and typical hearing students of the same grade and also to evaluate the effects of group, sex, hearing age, and educational grade of the students on their spoken/written narrative performance. Methods: The subjects were 174 students aged 10-13 years, 54 of whom wore cochlear implants, 60 suffered from moderate to severe hearing losses and wore hearing aids, with the remaining 60 students being typical hearing in terms of the sense of hearing...
June 19, 2018: Clinical and Experimental Otorhinolaryngology
Amir Shamloo, Mohsen Asadbegi, Vahid Khandan, Amirhossein Amanzadi
According to the Amyloid hypothesis, as the foremost scientific explanation for Alzheimer Disease (AD), the neuropathology of AD is related to toxic fragments of amyloid beta (Aβ) protein. Based on this hypothesis, an attractive therapeutic approach was demonstrated to identify multifunctional peptides able to modulate Aβ pathologies as the source of AD. On this premise, a bifunctional polypeptide based on the iAβ5p lead compound, was designed to inhibit Aβ aggregation and free metal ions. Herein, the efficacy of this novel drug in Zn2+ and Cd2+ ion chelation was examined through an integrated technique comprising combined Docking, QM, and MD simulations...
June 12, 2018: Archives of Biochemistry and Biophysics
Reza Heidari, Akram Jamshidzadeh, Vahid Ghanbarinejad, Mohammad Mehdi Ommati, Hossein Niknahad
Aim of the study: Hepatic encephalopathy and hyperammonemia is a clinical complication associated with liver cirrhosis. The brain is the target organ for ammonia toxicity. Ammonia-induced brain injury is related to oxidative stress, locomotor activity dysfunction, and cognitive deficit, which could lead to permanent brain injury, coma and death if not appropriately managed. There is no promising pharmacological intervention against cirrhosis-associated brain injury. Taurine (TAU) is one of the most abundant amino acids in the human body...
June 2018: Clinical and Experimental Hepatology
Qader Motarjemizadeh, Naser Samadi Aidenloo, Mohammad Abbaszadeh, Vahid Sadrinia
PURPOSE: The purpose of this study is to compare the long-term outcomes of intravitreal bevacizumab (IVB) with a combination therapy including IVB/intravitreal triamcinolone acetonide (IVB/IVTA) in neovascular age-related macular degeneration (AMD). MATERIALS AND METHODS: This prospective, randomized clinical trial was conducted on 136 eyes of 136 patients with neovascular AMD. Eyes were randomly assigned to receive IVB alone (71 eyes) or in combination with IVTA (65 eyes)...
January 2018: Middle East African Journal of Ophthalmology
Mohammad Reza Bakhtiarizadeh, Maryam Rahimi, Abdollah Mohammadi-Sangcheshmeh, Vahid Shariati J, Seyed Alireza Salami
Successful spermatogenesis and oogenesis are the two genetically independent processes preceding embryo development. To date, several fertility-related proteins have been described in mammalian species. Nevertheless, further studies are required to discover more proteins associated with the development of germ cells and embryogenesis in order to shed more light on the processes. This work builds on our previous software (OOgenesis_Pred), mainly focusing on algorithms beyond what was previously done, in particular new fertility-related proteins and their classes (embryogenesis, spermatogenesis and oogenesis) based on the support vector machine according to the concept of Chou's pseudo-amino acid composition features...
June 13, 2018: Scientific Reports
Vahid Saheb, Meymanat Zokaie
The multi-channel thermal decomposition of acetone is studied theoretically. The isomerization of acetone molecule to its enol form, 1-propene-2-ol, is of especial interest in this research. Steady-state approximation is applied to the thermally-activated species CH3COCH3* and CH2C(CH3)OH*, and by performing some statistical mechanical manipulations, integral expressions for the rate constants for the formation of different products are derived. The geometries of the reactant, intermediate, transition states and products of the reaction are optimized at the MP2(full)/6-311++G(2d,2p) level of theory...
June 13, 2018: Journal of Physical Chemistry. A
Mahdi Rahimi, Vahid Shafiei-Irannejad, Kazem D Safa, Roya Salehi
A possible approach for clinical cancer treatment is combination chemotherapy. To address this issue, many anticancer agents have been used simultaneously to achieve synergistic effects with the different mechanism of actions, however, their toxic side effects are still a big challenge. In this study, a smart, biocompatible, magnetic nanocarrier composed of multi-branched ionic liquid-chitosan grafted mPEG was designed and used for targeted multidrug delivery of DOX and MTX as model anticancer agents to MCF7 breast cancer cells...
September 15, 2018: Carbohydrate Polymers
David Boutboul, Hye Sun Kuehn, Zoé Van de Wyngaert, Julie E Niemela, Isabelle Callebaut, Jennifer Stoddard, Christelle Lenoir, Vincent Barlogis, Catherine Farnarier, Frédéric Vely, Nao Yoshida, Seiji Kojima, Hirokazu Kanegane, Akihiro Hoshino, Fabian Hauck, Ludovic Lhermitte, Vahid Asnafi, Philip Roehrs, Shaoying Chen, James W Verbsky, Katherine R Calvo, Ammar Husami, Kejian Zhang, Joseph Roberts, David Amrol, John Sleaseman, Amy P Hsu, Steven M Holland, Rebecca Marsh, Alain Fischer, Thomas A Fleisher, Capucine Picard, Sylvain Latour, Sergio D Rosenzweig
Ikaros/IKZF1 is an essential transcription factor expressed throughout hematopoiesis. IKZF1 is implicated in lymphocyte and myeloid differentiation and negative regulation of cell proliferation. In humans, somatic mutations in IKZF1 have been linked to the development of B cell acute lymphoblastic leukemia (ALL) in children and adults. Recently, heterozygous germline IKZF1 mutations have been identified in patients with a B cell immune deficiency mimicking common variable immunodeficiency. These mutations demonstrated incomplete penetrance and led to haploinsufficiency...
June 11, 2018: Journal of Clinical Investigation
Saeid Mahdavi Omran, Maryam Rezaei Dastjerdi, Maryam Zuashkiani, Vahid Moqarabzadeh, Mojtaba Taghizadeh-Armaki
Background: Candida -associated denture stomatitis (CADS) is a common fungal infection in people who wear dentures. The main objective of this study was to make molecular identification of causative agents of CADS and in vitro antifungal susceptibility testing (AFST) in the Iranian patients with denture stomatitis. Methods: A total of 134 Candida spp. were obtained from patients with denture stomatitis. The Candida spp. were identified using a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) involving the universal internal transcribed spacer (ITS1 and ITS4) primers, which were subjected to digestion with MspI and BlnI restriction enzymes...
2018: BioMed Research International
Mehdi Azami, Vahid Ranjkesh Adermanabadi, Hossein Khanahmad, Mohammad Ali Mohaghegh, Ebtesam Zaherinejad, Maryam Aghaei, Akram Jalali, Seyed Hossein Hejazi
Leishmania infantum is the causative agent of infantile visceral leishmaniasis (VL) in the Mediterranean region. Despite developing protective responses, the disease progresses due to many of factors. These include the action of suppressive cytokines, exhaustion of specific T cells, loss of lymphoid tissue, and defective humoral response. Genetic changes that occur inside the genome of alienated or parasite cells, along with immune responses, play an important role in controlling or progressing the disease...
2018: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
Hadi Hassankhani, Vahid Zamanzade, Azad Rahmani, Hamidreza Haririan, Joanne E Porter
No abstract text is available yet for this article.
August 2018: International Journal of Nursing Studies
Felix Ellett, Vahid Pazhakh, Luke Pase, Erica L Benard, Harshini Weerasinghe, Denis Azabdaftari, Sultan Alasmari, Alex Andrianopoulos, Graham J Lieschke
Neutrophils and macrophages provide the first line of cellular defence against pathogens once physical barriers are breached, but can play very different roles for each specific pathogen. This is particularly so for fungal pathogens, which can occupy several niches in the host. We developed an infection model of talaromycosis in zebrafish embryos with the thermally-dimorphic intracellular fungal pathogen Talaromyces marneffei and used it to define different roles of neutrophils and macrophages in infection establishment...
June 8, 2018: PLoS Pathogens
Vahid Ansari, John M Donohue, Markus Allgaier, Linda Sansoni, Benjamin Brecht, Jonathan Roslund, Nicolas Treps, Georg Harder, Christine Silberhorn
High-dimensional quantum information processing promises capabilities beyond the current state of the art, but addressing individual information-carrying modes presents a significant experimental challenge. Here we demonstrate effective high-dimensional operations in the time-frequency domain of nonclassical light. We generate heralded photons with tailored temporal-mode structures through the pulse shaping of a broadband parametric down-conversion pump. We then implement a quantum pulse gate, enabled by dispersion-engineered sum-frequency generation, to project onto programmable temporal modes, reconstructing the quantum state in seven dimensions...
May 25, 2018: Physical Review Letters
Leila Kazazi, Mahshid Foroughan, Vahid Nejati, Mohsen Shati
Background: Age associated cognitive decline or normal cognitive aging is related with lower levels of functioning in real life, and may interfere with maintaining independence and health related quality of life (HRQL). Objective: In this study, health related quality of life and cognitive function in community-dwelling older adults were evaluated with the aim of exploring the association between them by adjusting for potential confounders. Methods: This cross-sectional study, was implemented on 425 community-dwelling older adults aged 60 and over, between August 2016 and October 2016 in health centers of the municipality of Tehran, Iran, using Mini Mental State Examination (MMSE) to assess cognitive function and Short Form-36 scales (SF-36) to assess HRQL...
April 2018: Electronic Physician
Mahshid Tahamtan, Vahid Sheibani, Seyed Mostafa Shid Moosavi, Majid Asadi-Shekaari, Saeed Esmaeili-Mahani, Iraj Aghaei, Mohammad Shabani
One of the most common causes of mortality in acute kidney injury is brain dysfunction. Here we investigated the possible protective effect of erythropoietin (EPO) on cognitive impairments induced by bilateral renal ischemia (BRI). Eighty male Wistar rats were allocated into 8 groups: 1, 2) Sham +V (Vehicle), 3, 4) Sham+EPO, 5, 6) BRI+V, 7, 8) BRI+EPO. The groups followed by the reperfusion periods of 24hours (24 h) and 1week (1w). EPO or saline was administrated 30 min before surgery (1000 IU/kg, i.p). The cognitive function was assessed by passive avoidance learning and Morris water maze tests...
2018: Iranian Journal of Pharmaceutical Research: IJPR
Mahmood Alimohammadi, Mahmood Yousefi, Fatemeh Azizi Mayvan, Vahid Taghavimanesh, Hossein Navai, Ali Akbar Mohammadi
The data presented in this article are related to the research article entitled "knowledge, attitude and performance regarding waste management among the HCWs in hospitals affiliated with the Neyshabur City, Iran". A researcher-made questionnaire (accessible as an attachment) containing 4 parts of demographic information, knowledge (24 questions), attitude (6 questions) and practices (6 questions) was used for data gathering. Kruskal- Wallis test, Mann-Whitney U and Spearman correlation coefficient were used to analyze the data...
April 2018: Data in Brief
Mina Riahi, Ali Akbar Mohammadi, Vahid Kazemi Moghadam, Zahra Sadat Robati, Mohammad Bidkhori
The present study investigated the effect of human development index (HDI) on diarrheal deaths per 1000 live births in children under 5 years old in 2015. In addition, the association between HDI, and the use of improved drinking-water sources and sanitation facilities were evaluated in this year. 75 countries that their information was available in Global Analysis and Assessment of Sanitation and Drinking-Water (GLAAS) conducted by the World Health Organization (WHO) were included in this study. The data required was obtained from WHO and United Nations Development Programme (UNDP) websites...
April 2018: Data in Brief
Mahmood Yousefi, Mohammad Hadi Dehghani, Saba Maghsoudi Nasab, Vahid Taghavimanesh, Shahrokh Nazmara, Ali Akbar Mohammadi
The data of this study was to determine the groundwater quality trend changes in Abhar city (Iran) during one decade (2002-2016). In the first and end year of the study period, the Mean±SD of total hardness (as calcium carbonate, mg/l), electrical conductivity (as micromhos/cm) and total dissolved solid in the first and end year of the study period were 192.69±56.83, 235.25±84.73 and 606.21±194.69, 744.55±288.52 and 348.79±106.81, 464.71±183.52 respectively. On the basis of Pearson correlation coefficient, the ascending trend of some parameters concentration with time was significant at the level of 95% of confidence limits (α ≤ 0...
April 2018: Data in Brief
Parisa Ashournia, Payman Sadeghi, Nima Rezaei, Mohammad-Hassan Moradinejad, Vahid Ziaee
One of the causes of infants' hospitalizations is bronchiolitis, while different viral agents could be causative agents. As there is little information regarding the common agents of bronchiolitis in Iranian infants, we designed this study to determine which agents were responsible for hospitalization due to bronchiolitis among infants in an Iranian tertiary center. Two hundred and three infants with bronchiolitis who were hospitalized in Bahrami hospital were enrolled. Data regarding age, sex, duration of hospitalization, exposure to smoking, previous antibiotic usage and fever were collected for all enrolled cases...
March 2018: Mædica
Dena Sadeghi Bahmani, Leila Esmaeili, Vahid Shaygannejad, Markus Gerber, Juerg Kesselring, Undine E Lang, Edith Holsboer-Trachsler, Serge Brand
Background: Previous research of patients with multiple sclerosis (MS) focused prevalently on fatigue, depression, and cognitive dysfunction during the clinical course. By contrast, research on the longer-term characteristics of physical activity (PA), psychological functioning, and sleep problems is scarce. The aims of the present study were therefore to examine changes in PA, mental toughness (MT) as a proxy of psychological functioning, and sleep disturbances over a 2-year period of time after disease onset...
2018: Frontiers in Psychiatry
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