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https://www.readbyqxmd.com/read/29220086/zinc-against-advanced-glycation-end-products
#1
REVIEW
Sorayya Kheirouri, Mohammad Alizadeh, Vahid Maleki
Advanced glycation end products (AGEs) are destructive compounds with pathogenic importance in age-related chronic diseases. Zinc has anti-oxidant, anti-inflammatory and anti-apoptotic potential. This study was aimed to summarize effects of zinc on AGEs formation and AGEs induced damaging agents. Pubmed, Google scholar, Web of Sciences, and Scopus databases were searched. There was no limitation for publication date. English language original articles (in vitro, experimental and human studies) which examined the effect of external zinc on AGEs formation, AGEs- induced apoptosis, or oxidative stress in mammals were included...
December 8, 2017: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/29216604/digital-holographic-microscopy-for-3d-surface-characterization-of-polymeric-nanocomposites
#2
Vahid Abbasian, Ehsan A Akhlaghi, Mohammad A Charsooghi, Maasoomeh Bazzar, Ali-Reza Moradi
The aim of this paper is to introduce digital holographic microscopy (DHM) as a non-contact, inexpensive, and non-abrasive method for 3D surface characterization of polymeric nanocomposites. A common-path and vibration-immune Mirau system with a microsphere-assisted arrangement is utilized to increase the lateral resolution of the images. The characterization is performed through the measurement of roughness parameters of the surfaces, which are derived from the recorded holograms. Pure poly(triazole-amide-imide) (PTAI) and PTAI nanocomposite reinforeced with surface modified TiO2 nanoparticles (MN-TiO2) are used and compared...
November 28, 2017: Ultramicroscopy
https://www.readbyqxmd.com/read/29214868/sulfasalazine-induces-mitochondrial-dysfunction-and-renal-injury
#3
Hossein Niknahad, Reza Heidari, Roya Mohammadzadeh, Mohammad Mehdi Ommati, Forouzan Khodaei, Negar Azarpira, Narges Abdoli, Mahdi Zarei, Behnam Asadi, Maryam Rasti, Babak Shirazi Yeganeh, Vahid Taheri, Arastoo Saeedi, Asma Najibi
Sulfasalazine is a commonly used drug for the treatment of rheumatoid arthritis and inflammatory bowel disease. There are several cases of renal injury encompass sulfasalazine administration in humans. The mechanism of sulfasalazine adverse effects toward kidneys is obscure. Oxidative stress and its consequences seem to play a role in the sulfasalazine-induced renal injury. The current investigation was designed to investigate the effect of sulfasalazine on kidney mitochondria. Rats received sulfasalazine (400 and 600 mg/kg/day, oral) for 14 consecutive days...
November 2017: Renal Failure
https://www.readbyqxmd.com/read/29206437/ultra-low-threshold-and-lightweight-biodegradable-porous-pla-mwcnt-with-segregated-conductive-networks-for-high-performance-thermal-insulation-and-electromagnetic-interference-shielding-applications
#4
Guilong Wang, Long Wang, Lun Howe Mark, Vahid Shaayegan, Guizhen Wang, Huiping Li, Guoqun Zhao, Chul B Park
Lightweight, biodegradable, thermal insulation and electrically conductive materials play a vital role in achieving the sustainable development of our society. The fabrication of such multifunctional materials is currently very challenging. Here, we report a general, facile and eco-friendly way for the large-scale fabrication of ultra-low threshold and biodegradable porous PLA/MWCNT for high-performance thermal insulation and EMI shielding applications. Thanks to the unique structure with microporous PLA matrix embedded by conductive 3D MWCNT networks, the lightweight porous PLA/MWCNT with a density of 0...
December 5, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29205905/a-simple-modification-method-to-obtain-anisotropic-and-porous-3d-microfibrillar-scaffolds-for-surgical-and-biomedical-applications
#5
Vahid Hosseini, Olivera Evrova, Simon P Hoerstrup, Viola Vogel
In native tissues, cellular organization is predominantly anisotropic. Yet, it remains a challenge to engineer anisotropic scaffolds that promote anisotropic cellular organization at macroscopic length scales. To overcome this challenge, an innovative, cheap and easy method to align clinically approved non-woven surgical microfibrillar scaffolds is presented. The method involves a three-step process of coating, unidirectional stretching of scaffolds after heating them above glass transition temperature, and cooling back to room temperature...
December 4, 2017: Small
https://www.readbyqxmd.com/read/29204954/chronic-fluoxetine-induces-activity-changes-in-recovery-from-poststroke-anxiety-depression-and-cognitive-impairment
#6
Faranak Vahid-Ansari, Paul R Albert
Poststroke depression (PSD) is a common outcome of stroke that limits recovery and is only partially responsive to chronic antidepressant treatment. In order to elucidate changes in the cortical-limbic circuitry associated with PSD and its treatment, we examined a novel mouse model of persistent PSD. Focal endothelin-1-induced ischemia of the left medial prefrontal cortex (mPFC) in male C57BL6 mice resulted in a chronic anxiety and depression phenotype. Here, we show severe cognitive impairment in spatial learning and memory in the stroke mice...
December 4, 2017: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://www.readbyqxmd.com/read/29204382/effect-of-material-and-wall-thickness-buildup-caps-on-the-head-scatter-factor-measurements-in-irregular-fields-shielded-by-cerrobend
#7
Ali Jomehzadeh, Daryoush Shahbazi-Gahrouei, Vahid Jahanbakhsh
The head scatter factor (Sc ) is important to measurements radiation beam and beam modeling of treatment planning systems used for advanced radiation therapy techniques. This study aimed to investigate the design of a miniphantom to measurement variations in collimator Sc in the presence of shielding blocks for shaping the beam using different field sizes. Copper, Brass, and Perspex buildup caps were designed and fabricated locally as material with three different thicknesses for buildup caps (miniphantoms)...
October 2017: Journal of Medical Signals and Sensors
https://www.readbyqxmd.com/read/29202689/explorative-visual-analytics-on-interval-based-genomic-data-and-their-metadata
#8
Vahid Jalili, Matteo Matteucci, Marco Masseroli, Stefano Ceri
BACKGROUND: With the wide-spreading of public repositories of NGS processed data, the availability of user-friendly and effective tools for data exploration, analysis and visualization is becoming very relevant. These tools enable interactive analytics, an exploratory approach for the seamless "sense-making" of data through on-the-fly integration of analysis and visualization phases, suggested not only for evaluating processing results, but also for designing and adapting NGS data analysis pipelines...
December 4, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/29202365/development-of-reduction-scenarios-for-criteria-air-pollutants-emission-in-tehran-traffic-sector-iran
#9
Amir Mohammadiha, Hossein Malakooti, Vahid Esfahanian
Transport-related pollution as the main source of air pollution must be reduced in Tehran mega-city. The performance of various developed scenarios including BAU (Business As Usual) as baseline scenario, ECV (Elimination of carburetor equipped Vehicle), NEM (New Energy Motorcycles), HES (Higher Emission Standard), VCR (Vehicle Catalyst Replacement), FQE (Fuel Quality Enhancement), DPF (Diesel Particulate Filter) and TSA (Total Scenarios Aggregation) are evaluated by International Vehicle Model up to 2028. In the short term, the ECV, VCR, and FQE scenarios provided high performance in CO, VOCs and NOx emissions control...
December 1, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29201455/optofluidic-lab-on-a-chip-fluorescence-sensor-using-integrated-buried-arrow-barrow-waveguides
#10
Thomas Wall, Johnny McMurray, Gopikrishnan Meena, Vahid Ganjalizadeh, Holger Schmidt, Aaron R Hawkins
Optofluidic, lab-on-a-chip fluorescence sensors were fabricated using buried anti-resonant reflecting optical waveguides (bARROWs). The bARROWs are impervious to the negative water absorption effects that typically occur in waveguides made using hygroscopic, plasma-enhanced chemical vapor deposition (PECVD) oxides. These sensors were used to detect fluorescent microbeads and had an average signal-to-noise ratio (SNR) that was 81.3% higher than that of single-oxide ARROW fluorescence sensors. While the single-oxide ARROW sensors were annealed at 300 °C to drive moisture out of the waveguides, the bARROW sensors required no annealing process to obtain a high SNR...
August 2017: Micromachines
https://www.readbyqxmd.com/read/29201116/fluoxetine-regulates-ig-kappa-chain-c-region-expression-levels-in-the-serum-of-obsessive-compulsive-disorder-patients-a-proteomic-approach
#11
Mona Zamanian Azodi, Mostafa Rezaei Tavirani, Afsaneh Arefi Oskouie, Mostafa Hamdieh, Mohammad Kamran Derakhshan, Alireza Ahmadzadeh, Farid Zayeri, Naser Nejadi, Majid Rezaei Tavirani, Vahid Mansouri, Mohammad Rostami-Nejad, Reza Vafaee
Obsessive-Compulsive Disorder (OCD) is one of the most common mental conditions. Proteome profiling may help identifying important proteins and finally shed lights to complexity of OCD underlying mechanisms. Here, by the application gel-based proteomic approach the proteome profile of patients with washing subtype of OCD before and after treatment with Fluoxetine (positive responders) are compared to healthy matched controls. However, only one of the differentially expressed proteins is examined and introduced in this paper...
2017: Iranian Journal of Pharmaceutical Research: IJPR
https://www.readbyqxmd.com/read/29199882/association-study-of-mecp2-gene-single-nucleotide-polymorphisms-in-juvenile-onset-systemic-lupus-erythematosus-patients-from-iran
#12
Mahdi Mahmoudi, Saeed Aslani, Elham Hamzeh, Vahid Ziaee, Shiva Poursani, Mohammad Hossein Nicknam, Nima Rezaei
INTRODUCTION: Juvenile-onset systemic lupus erythematosus is a multigenic autoimmune disorder. Polymorphisms of MECP2 gene have been reported to increase the risk of adult-onset SLE. In this study, we aimed to analyze if MECP2 gene polymorphisms could impress the proneness to JSLE in Iranian population. MATERIAL AND METHODS: Polymorphisms of MECP2 gene were genotyped in 50 Iranian JSLE patients and 426 matched healthy controls employing the real-time PCR allelic discrimination technique...
December 4, 2017: Fetal and Pediatric Pathology
https://www.readbyqxmd.com/read/29195114/cutaneous-anaplastic-large-cell-lymphoma-in-a-multiple-sclerosis-patient-receiving-fingolimod
#13
Navid Manouchehri, Omid Mirmosayyeb, Shervin Badihian, Vahid Shaygannejad
BACKGROUND: Previous reports of cutaneous neoplastic lesions secondary to Fingolimod treatment among multiple sclerosis patients. OBJECTIVE: Reporting a case of cutaneous large cell lymphoma in a multiple sclerosis patient during Fingolimod treatment. METHOD: Case study. RESULT: Our patient developed CD30+ cutaneous large cell lymphoma two years after initiation of Fingolimod treatment and her symptoms regressed following the cessation of treatment...
November 22, 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29194711/institutional-decision-to-adopt-y90-as-primary-treatment-for-hcc-informed-by-a-1-000-patient-15-year-experience
#14
Riad Salem, Ahmed Gabr, Ahsun Riaz, Ronald Mora, Rehan Ali, Michael Abecassis, Ryan Hickey, Laura Kulik, Daniel Ganger, Steven Flamm, Rohi Atassi, Bassel Atassi, Kent Sato, Al B Benson, Mary F Mulcahy, Nadine Abouchaleh, Ali Al Asadi, Kush Desai, Bartley Thornburg, Michael Vouche, Ali Habib, Juan Caicedo, Frank H Miller, Vahid Yaghmai, Joseph R Kallini, Samdeep Mouli, Robert J Lewandowski
Y90 transarterial radioembolization (TARE) is a transarterial locoregional therapy (LRT) for hepatocellular carcinoma (HCC). In this study, we present overall survival outcomes (OS) in a 1000-patient cohort acquired over a 15-year period. Between December 1, 2003 and March 31, 2017, 1000 patients with HCC were treated with TARE as part of a prospective cohort study. A comprehensive review of toxicity and survival outcomes was performed. Outcomes were stratified by baseline Child-Pugh (CP) class, United Network for Organ Sharing (UNOS) and Barcelona Clinic Liver Cancer (BCLC) staging systems...
December 1, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29194612/nanocurcumin-restores-aberrant-mirna-expression-profile-in-multiple-sclerosis-randomized-double-blind-placebo-controlled-trial
#15
Sanam Dolati, Leili Aghebati Maleki, Majid Ahmadi, Faroogh Marofi, Zohreh Babaloo, Hormoz Ayramloo, Zahra Jafarisavari, Hamid Oskouei, Amir Afkham, Vahid Younesi, Mohammad Nouri, Mehdi Yousefi
OBJECTIVE: In the current study, we aimed to identify nanocurcumin effects on microRNAs (miRNAs) in the peripheral blood of patients with relapsing-remitting multiple sclerosis (RRMS). We intended to investigate the expression pattern of these miRNAs in experimental settings in vivo. METHODS: The expression levels of the selected 27 miRNAs known to be involved in the regulation of immune responses were analyzed in 50 RRMS patients and 35 healthy controls. The miRNA expression profiles were investigated by quantitative PCR (qPCR) at baseline and after 6 months of nanocurcumin therapy...
December 1, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29192363/quantitative-and-visual-assessments-toward-potential-sub-msv-or-ultrafast-fdg-pet-using-high-sensitivity-tof-pet-in-pet-mri
#16
Spencer C Behr, Emma Bahroos, Randall A Hawkins, Lorenzo Nardo, Vahid Ravanfar, Emily V Capbarat, Youngho Seo
PURPOSE: Newer high-performance time-of-flight (TOF) positron emission tomography (PET) systems have the capability to preserve diagnostic image quality with low count density, while maintaining a high raw photon detection sensitivity that would allow for a reduction in injected dose or rapid data acquisition. To assess this, we performed quantitative and visual assessments of the PET images acquired using a highly sensitive (23.3 cps/kBq) large field of view (25-cm axial) silicon photomultiplier (SiPM)-based TOF PET (400-ps timing resolution) integrated with 3 T-MRI in comparison to PET images acquired on non-TOF PET/x-ray computed tomography (CT) systems...
November 30, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/29190188/biomeasures-and-mechanistic-modeling-highlight-pk-pd-risks-for-a-monoclonal-antibody-targeting-fn14-in-kidney-disease
#17
Xiaoying Chen, Vahid Farrokhi, Pratap Singh, Mireia Fernandez Ocana, Jenil Patel, Lih-Ling Lin, Hendrik Neubert, Joanne Brodfuehrer
Discovery of the upregulation of fibroblast growth factor-inducible-14 (Fn14) receptor following tissue injury has prompted investigation into biotherapeutic targeting of the Fn14 receptor for the treatment of conditions such as chronic kidney diseases. In the development of monoclonal antibody (mAb) therapeutics, there is an increasing trend to use biomeasures combined with mechanistic pharmacokinetic/pharmacodynamic (PK/PD) modeling to enable decision making in early discovery. With the aim of guiding preclinical efforts on designing an antibody with optimized properties, we developed a mechanistic site-of-action (SoA) PK/PD model for human application...
November 30, 2017: MAbs
https://www.readbyqxmd.com/read/29184578/the-effect-of-emotional-intelligence-training-on-self-efficacy-in-women-with-multiple-sclerosis
#18
Zahra Mehrabi, Fatemeh Nazari, Tayebe Mehrabi, Vahid Shaygannejad
Background: Multiple sclerosis (MS), a chronic disease of the central nervous system (CNS), causing progressive nerve damage, has disabling symptoms, and undermines self-efficacy beliefs. Due to the importance of self-efficacy modified in adaptation and coping with stress, this study was conducted with the aim to investigate the effect of emotional intelligence training on self-efficacy in women with MS. Materials and Methods: This randomized clinical trial was conducted on 70 women referring to the Multiple Sclerosis Clinic of Kashani Hospital, Isfahan, Iran...
November 2017: Iranian Journal of Nursing and Midwifery Research
https://www.readbyqxmd.com/read/29180112/mri-evaluation-of-the-effects-of-extension-exercises-on-the-disc-fluid-content-and-location-of-the-centroid-of-the-fluid-distribution
#19
Vahid Abdollah, Eric C Parent, Michele C Battié
BACKGROUND: McKenzie prone press-up exercises have been hypothesised to reduce intradiscal pressure, allowing fluid to be reabsorbed into the disc, which could improve the internal stability and local chemical milieu of the disc, potentially reducing symptoms. OBJECTIVE: To investigate the immediate effects of prone press-up exercises on lumbar disc fluid content and movement. DESIGN: Quantification of MRI changes before and after a single exercise session...
November 21, 2017: Musculoskeletal Science & Practice
https://www.readbyqxmd.com/read/29177171/grafting-with-cryopreserved-amniotic-membrane-versus-conservative-wound-care-in-treatment-of-pressure-ulcers-a-randomized-clinical-trial
#20
Mehdi Dehghani, Negar Azarpira, Vahid Mohammad Karimi, Hamid Mossayebi, Elaheh Esfandiari
Objective: To compare the healing process of pressure ulcers treated with cryopreserved human amniotic membrane allograft and routine pressure ulcer care in our hospital. Methods: From January 2012 to December 2013, in a prospective randomized clinical trial (IRCT201612041335N2), 24 patients with second and third stage of pressure ulcers were enrolled in this study. All patients needed split-thickness skin grafts for pressure ulcer-wound coverage. Selected patients had symmetric ulcers on both upper and lower extremities...
October 2017: Bulletin of Emergency and Trauma
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