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https://www.readbyqxmd.com/read/29224239/personalized-stepwise-vascular-control-during-complex-hepatectomy-involving-hepatocaval-confluence
#1
Lei Dou, Zong-Ping Yu, Hui-Yuan Yang, Ji Ran, Yi-Fa Chen, Xiao-Ping Chen
BACKGROUND: This study introduces an innovative stepwise vascular control technique to address the high risk of massive bleeding from main hepatic veins and the retro-hepatic inferior vena cava during hepatectomy involving hepatocaval confluence. METHODS: From January 2010 to July 2016, 80 patients underwent stepwise vascular occlusion during complex liver resection involving hepatocaval confluence. Relevant clinical data were collected and compared with those obtained in parallel studies...
December 10, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/29224121/high-definition-infrared-thermography-of-ice-nucleation-and-propagation-in-wheat-under-natural-frost-conditions-and-controlled-freezing
#2
David P Livingston, Tan D Tuong, J Paul Murphy, Lawrence V Gusta, Ian Willick, Micheal E Wisniewski
An extremely high resolution infrared camera demonstrated various freezing events in wheat under natural conditions. Many of those events shed light on years of misunderstanding regarding freezing in small grains. Infrared thermography has enhanced our knowledge of ice nucleation and propagation in plants through visualization of the freezing process. The majority of infrared analyses have been conducted under controlled conditions and often on individual organs instead of whole plants. In the present study, high-definition (1280 × 720 pixel resolution) infrared thermography was used under natural conditions to visualize the freezing process of wheat plants during freezing events in 2016 and 2017...
December 9, 2017: Planta
https://www.readbyqxmd.com/read/29224022/bladder-fetal-rhabdomyoma-intermediate-type
#3
L González-Pérez, H Alvarez-Argüelles, V J Ramos Gutiérrez, S García Hernández, A C Plata Bello, T Concepción Masip, E Salido Ruiz
INTRODUCTION: Rhabdomyomas are benign tumors of striated muscle, the bladder localization is very rare. CLINICAL CASE: We present an 87-year-old male consulting for gross hematuria. Cystoscopy was done with evidence of bulged bladder mucosa in right side wall and dome. Post-transurethral resection of the bladder (TURB) pathological anatomy was negative for malignancy. As extension study abdominopelvic computed tomography was performed identifying a bladder thickening of right posterior sidewall and an increased density of the adjacent fat...
December 8, 2017: Urologia Internationalis
https://www.readbyqxmd.com/read/29223954/effect-of-pcsk9-inhibitors-on-clinical-outcomes-in-patients-with-hypercholesterolemia-a-meta-analysis-of-35-randomized-controlled-trials
#4
REVIEW
Aris Karatasakis, Barbara A Danek, Judit Karacsonyi, Bavana V Rangan, Michele K Roesle, Thomas Knickelbine, Michael D Miedema, Houman Khalili, Zahid Ahmad, Shuaib Abdullah, Subhash Banerjee, Emmanouil S Brilakis
BACKGROUND: We sought to examine the efficacy and safety of 2 PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibitors: alirocumab and evolocumab. METHODS AND RESULTS: We performed a systematic review and meta-analysis of randomized controlled trials comparing treatment with and without PCSK9 inhibitors; 35 randomized controlled trials comprising 45 539 patients (mean follow-up: 85.5 weeks) were included. Mean age was 61.0±2.8 years, and mean baseline low-density lipoprotein cholesterol was 106±22 mg/dL...
December 9, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29223947/-trigeminy-of-ventricular-bigeminy-caused-by-reentrant-mechanism-reentry-of-reentry
#5
Oscar A Pellizzón, Marcelo V Elizari
The process that follows an acute myocardial infarction generates an appropriate substrate for the formation of reentry circuits, considered to be the most frequent mechanism of ventricular extrasystoles and tachyarrhythmias. We present the case of a patient with an acute myocardial infarction unusually concurring with ventricular trigeminy coupled to ventricular bigeminated extrasystoles giving rise to a trigeminy sequence over the bigeminy, which indicates the existence of two reentry circuits (reentry of reentry) that trigger ventricular flutter...
2017: Medicina
https://www.readbyqxmd.com/read/29223936/-relationship-between-crowding-and-community-acquired-skin-and-soft-tissues-infections
#6
Marcelo A Beltrán, Horacio J García Del Corro, Mónica Couso, María D Gallo, Antonio Lettieri, Patricia V Barna
The association of the spread of community infections with poverty and overcrowding is well known. In our hospital, located in José C. Paz, we assist sporadic cases of post-cesarean infections caused by community acquired methicillin-resistant Staphylococcus aureus (CaMRSA). In a prospective study of families treated at our hospital, we investigated the relationship between a history of skin and soft tissue infections (SSTI) and extreme overcrowding defined as households with unsatisfied basic needs type 3 (NBI 3)...
2017: Medicina
https://www.readbyqxmd.com/read/29223902/people-pollution-and-pathogens-global-change-impacts-in-mountain-freshwater-ecosystems
#7
REVIEW
Dirk S Schmeller, Adeline Loyau, Kunshan Bao, Werner Brack, Antonis Chatzinotas, Francois De Vleeschouwer, Jan Friesen, Laure Gandois, Sophia V Hansson, Marilen Haver, Gaël Le Roux, Ji Shen, Roman Teisserenc, Vance T Vredenburg
Mountain catchments provide for the livelihood of more than half of humankind, and have become a key destination for tourist and recreation activities globally. Mountain ecosystems are generally considered to be less complex and less species diverse due to the harsh environmental conditions. As such, they are also more sensitive to the various impacts of the Anthropocene. For this reason, mountain regions may serve as sentinels of change and provide ideal ecosystems for studying climate and global change impacts on biodiversity...
December 7, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29223894/a-model-based-fish-bioassessment-index-for-eastern-mediterranean-rivers-application-in-a-biogeographically-diverse-area
#8
S Zogaris, V Tachos, A N Economou, Y Chatzinikolaou, N Koutsikos, S Schmutz
In ecosystems with high fish species endemicity, such as Mediterranean-type rivers, biogeographical differences among ecoregions present serious obstacles to developing broadly-applicable river bioassessment indices. This impediment has contributed to a serious time-lag in developing EU policy-relevant fish-based indices in the Eastern Mediterranean countries. Here we present the first model-based fish index for the Eastern Mediterranean (the Hellenic Fish Index, HeFI) in an effort to overcome biogeographic differences among the area's biotically heterogeneous rivers...
December 7, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29223892/liquid-chromatography-quadrupole-time-of-flight-mass-spectrometry-determination-of-six-pharmaceuticals-in-vegetal-biota-uptake-study-in-lavandula-dentata
#9
Sofía Barreales-Suárez, Manuel Callejón-Mochón, Stéphane Azoulay, Miguel Ángel Bello-López, Rut Fernández-Torres
A procedure based on microwave assisted extraction for the determination of 6 pharmaceuticals in samples of Lavandula dentata, Salicornia ramosissima and Juncus sp. by liquid chromatography-quadrupole time of flight mass spectrometry (LC-QTOF/MS) was optimized and validated. Best results were obtained using microwave assisted extraction of 1.0g of homogeneous lyophilized samples and 5mL of a mixture ACN:H2O (1:1 v/v) as extracting solvent. Analytical recoveries ranged from 60 to 107% with relative standard deviation (RSD) lower than 15%...
December 6, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29223890/gold-core-ceria-shell-based-redox-active-nanozyme-mimicking-the-biological-multienzyme-complex-phenomenon
#10
Stuti Bhagat, N V Srikanth Vallabani, Vaithiyalingam Shutthanandan, Mark Bowden, Ajay S Karakoti, Sanjay Singh
Catalytically active individual gold (Au) and cerium oxide (CeO2) nanoparticles (NPs) are well known to exhibit specific enzyme-like activities, such as natural catalase, oxidase, superoxide dismutase, and peroxidase enzymes. These activities have been maneuvered to design several biological applications such as immunoassays, glucose detection, radiation and free radical protection and tissue engineering. In biological systems, multienzyme complexes are involved in catalyzing important reactions of essential metabolic processes such as respiration, biomolecule synthesis, and photosynthesis...
December 7, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29223886/electrocatalytic-co2-reduction-catalyzed-by-nitrogenase-mofe-and-fefe-proteins
#11
Bo Hu, Derek F Harris, Dennis R Dean, T Leo Liu, Zhi-Yong Yang, Lance C Seefeldt
Nitrogenases catalyze biological dinitrogen (N2) reduction to ammonia (NH3), and also reduce a number of non-physiological substrates, including carbon dioxide (CO2) to formate (HCOO-) and methane (CH4). Three versions of nitrogenase are known (Mo-, V-, and Fe-nitrogenase), each showing different reactivities towards various substrates. Normally, electrons for substrate reduction are delivered by the Fe protein component of nitrogenase, with energy coming from the hydrolysis of 2 ATP to 2 ADP+2 Pi for each electron transferred...
December 5, 2017: Bioelectrochemistry
https://www.readbyqxmd.com/read/29223873/molecular-characterization-and-expression-profiles-of-lpxrfa-at-the-brain-pituitary-gonad-axis-of-half-smooth-tongue-sole-cynoglossus-semilaevis-during-ovarian-maturation
#12
Bin Wang, Quan Liu, Xuezhou Liu, Yongjiang Xu, Bao Shi
Gonadotropin-inhibitory hormone (GnIH) has been characterized by its ability to inhibit either basal or gonadotropin-releasing hormone (GnRH)-induced gonadotropin synthesis and release in birds and mammals. However, the physiological role of GnIH on the reproductive axis in fish remains inconclusive, with most studies focusing on the orders Cypriniformes and Perciformes. To gain insight into the role of GnIH in the regulation of reproduction in the order Pleuronectiformes, we first cloned the LPXRFa gene, the piscine ortholog of GnIH, in the half-smooth tongue sole...
December 6, 2017: Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/29223809/cadmium-induces-bnip3-dependent-autophagy-in-chicken-spleen-by-modulating-mir-33-ampk-axis
#13
Menghao Chen, Xiaojing Li, Ruifeng Fan, Jie Yang, Xi Jin, Sattar Hamid, Shiwen Xu
Cadmium (Cd), a widespread environmental pollutant, has toxic effects on organs including spleen. However, the underlying mechanisms of Cd induced spleen toxicity and the roles of micro-RNA (miRNA) in this process remain poorly understood. To investigate this, cadmium chloride (CdCl2, 10 mg/kg) was administered in the diet of chickens for 90 days. Electron microscopy, qPCR and Western blot were performed. Results showed that Cd exposure suppressed miR-33-5q which increased the levels of AMPK. Subsequently, significant decrease in AKT/mTOR signaling and HSP70 were observed...
December 6, 2017: Chemosphere
https://www.readbyqxmd.com/read/29223805/development-of-pyrrolo-2-1-c-1-4-benzodiazepine-%C3%AE-glucoside-prodrugs-for-selective-therapy-of-cancer
#14
Praveen Reddy Adiyala, Venkatesh Tekumalla, Ibrahim Bin Sayeed, V Lakshma Nayak, Apoorva Nagarajan, Mohd Adil Shareef, Burri Nagaraju, Ahmed Kamal
Cancer chemotherapy has several limitations such as often insufficient differentiation between malign tissue and benign tissue. The clinical utility of the pyrrolo[2,1-c][1,4]benzodiazepines (PBDs) are inadequate because of the lack of selectivity for tumor tissues, high reactivity of the pharmacophoric imine functionality, low water solubility, and stability. To address these limitations two new β-glucoside prodrugs of PBDs have been synthesized and evaluated for their potential use in selective therapy of solid tumors by ADEPT...
December 7, 2017: Bioorganic Chemistry
https://www.readbyqxmd.com/read/29223790/temporal-and-bi-directional-associations-between-sleep-duration-and-physical-activity-sedentary-time-in-children-an-international-comparison
#15
Yingyi Lin, Mark S Tremblay, Peter T Katzmarzyk, Mikael Fogelholm, Gang Hu, Estelle V Lambert, Carol Maher, Jose Maia, Timothy Olds, Olga L Sarmiento, Martyn Standage, Catrine Tudor-Locke, Jean-Philippe Chaput
The purpose of this multinational and cross-sectional study was to investigate whether nighttime sleep duration was associated with physical activity (PA) and sedentary time (SED) the following day, whether daytime PA/SED were associated with sleep duration the subsequent night, and whether the associations were modified by sex and study sites. Data from 5779 children aged 9-11years were analyzed. A waist-worn Actigraph GT3X+ accelerometer was used to assess children's 24-h movement behaviours for 7days, i...
December 6, 2017: Preventive Medicine
https://www.readbyqxmd.com/read/29223783/prior-stress-promotes-the-generalization-of-contextual-fear-memories-involvement-of-the-gabaergic-signaling-within-the-basolateral-amygdala-complex
#16
C L Bender, A Otamendi, G D Calfa, V A Molina
Fear generalization occurs when a response, previously acquired with a threatening stimulus, is transferred to a similar one. However, it could be maladaptive when stimuli that do not represent a real threat are appraised as dangerous, which is a hallmark of several anxiety disorders. Stress exposure is a major risk factor for the occurrence of anxiety disorders and it is well established that it influences different phases of fear memory; nevertheless, its impact on the generalization of contextual fear memories has been less studied...
December 6, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29223762/radioactivity-levels-in-the-atomic-mineral-occurrences-along-dharmapuri-shear-zone-in-parts-of-vellore-krishnagiri-dharmapuri-and-salem-districts-of-tamil-nadu-india
#17
Taru Bhattacharya, V Madhavi Shankar, B Ram Mohan Reddy, S Thangavel, P K Sharma
The aim of this study was to evaluate the concentrations of naturally occurring radioactive nuclides 226Ra, 232Th and 40K and corresponding dose rates over atomic mineral occurrences of Dharmapuri shear zone in parts of Salem, Dharmapuri, Krishnagiri, and Vellore districts of Tamilnadu, India. In this paper, area-wise ternary diagrams of Ra, Th and K were plotted to study their relative concentration in the samples. Correlation study was also carried out to delineate the contribution of individual radionuclides toward the measured gamma dose rate...
December 7, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/29223744/effect-of-various-antipsychotic-regimens-on-incidence-of-delirium-in-critically-ill-adults
#18
W Anthony Hawkins, Stephanie V Phan, Stacey L Campbell
PURPOSE: Delirium is common during critical illness but it is unknown whether the choice of antipsychotic or dosing strategy impacts delirium outcomes. We evaluated the incidence of delirium in critically ill adults receiving different antipsychotic regimens. MATERIALS AND METHODS: Single center retrospective cohort study of adult patients admitted to the intensive care unit (ICU). Patients who received haloperidol or quetiapine and scored negative on the Confusion Assessment Method for the ICU (CAM-ICU) prior to initiation were included...
November 28, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/29223722/the-effectiveness-of-intravenous-parecoxib-on-the-incidence-of-ipsilateral-shoulder-pain-after-thoracotomy-a-randomized-double-blind-placebo-controlled-trial
#19
Tanyong Pipanmekaporn, Yodying Punjasawadwong, Somrat Charuluxananan, Worawut Lapisatepun, Pavena Bunburaphong, Settapong Boonsri, Apichat Tantraworasin, Nutchanart Bunchungmongkol
OBJECTIVES: To determine the incidence of ipsilateral shoulder pain (ISP) with the therapeutic use of parecoxib compared with a placebo after thoracotomy. DESIGN: A prospective, randomized, double-blind, placebo-controlled trial. SETTING: A tertiary-care university hospital. PARTICIPANTS: Adult patients undergoing an elective thoracotomy between June 2011 and February 2015. INTERVENTIONS: Patients were allocated randomly into the parecoxib group (n = 80) and the control group (n = 80)...
June 1, 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29223716/alkaline-degradation-of-lyophilized-dmsa-prior-to-labeling-with-99mtc-identification-and-development-of-the-degradation-pathway-by-hplc-and-ms
#20
Erika V Almeida, Samuel L De Brito
INTRODUCTION: Complexes of technetium-99m (99mTc) with meso-dimercaptosuccinic acid (DMSA) have been widely used as diagnostic agents in nuclear medicine. The degradation products (DP) of DMSA formed under different forced conditions have been identified through HPLC-DAD and LC-MSn studies. In this study, the DMSA kit was subjected to forced degradation under hydrolysis conditions as prescribed by the International Conference on Harmonization (ICH) guideline Q1A. METHODS: Chromatographic separation was accomplished on a reverse phase Shim-Pack VP-ODS (150 mm × 4...
November 10, 2017: Nuclear Medicine and Biology
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