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https://www.readbyqxmd.com/read/29036922/microrna-and-mrna-dysregulation-in-astrocytes-infected-with-zika-virus
#1
Robert A Kozak, Anna Majer, Mia J Biondi, Sarah J Medina, Lee W Goneau, Babu V Sajesh, Jessy A Slota, Vanessa Zubach, Alberto Severini, David Safronetz, Shannon L Hiebert, Daniel R Beniac, Timothy F Booth, Stephanie A Booth, Gary P Kobinger
The Zika virus (ZIKV) epidemic is an ongoing public health concern. ZIKV is a flavivirus reported to be associated with microcephaly, and recent work in animal models demonstrates the ability of the virus to cross the placenta and affect fetal brain development. Recent findings suggest that the virus preferentially infects neural stem cells and thereby deregulates gene expression, cell cycle progression, and increases cell death. However, neuronal stem cells are not the only brain cells that are susceptible to ZIKV and infection of other brain cells may contribute to disease progression...
October 14, 2017: Viruses
https://www.readbyqxmd.com/read/29036917/the-effect-of-tio%C3%A2-doped-photocatalytic-nano-additives-on-the-hydration-and-microstructure-of-portland-and-high-alumina-cements
#2
María Pérez-Nicolás, Íñigo Navarro-Blasco, José M Fernández, José Ignacio Alvarez
Mortars with two different binders (Portland cement (PC) and high alumina cement (HAC)) were modified upon the bulk incorporation of nano-structured photocatalytic additives (bare TiO₂, and TiO₂ doped with either iron (Fe-TiO₂) or vanadium (V-TiO₂)). Plastic and hardened state properties of these mortars were assessed in order to study the influence of these nano-additives. Water demand was increased, slightly by bare TiO₂ and Fe-TiO₂, and strongly by V-TiO₂, in agreement with the reduction of the particle size and the tendency to agglomerate...
October 14, 2017: Nanomaterials
https://www.readbyqxmd.com/read/29036849/newly-developed-learning-and-verbal-memory-test-tamv-i-normative-data-for-spanish-speaking-pediatric-population
#3
D Rivera, L Olabarrieta-Landa, B V Rabago Barajas, M J Irías Escher, M Saracostti Schwartzman, R Ferrer-Cascales, P Martín-Lobo, J A Calderón, M A Aguilar Uriarte, A I Peñalver Guia, R Camlla Ynga, C E García-Guerrero, I Fernandez-Agis, A García-Gómez-Pastrana, J A Ibañéz-Alfonso, H Gómez, J Galarza-Del-Angel, C García de la Cadena, J C Arango-Lasprilla
OBJECTIVE: To generate normative data for the Learning and Verbal Memory Test (TAMV-I) in Spanish-speaking pediatric populations. METHOD: The sample consisted of 4,373 healthy children from nine countries in Latin America (Chile, Cuba, Ecuador, Guatemala, Honduras, Mexico, Paraguay, Peru, and Puerto Rico) and Spain. Each participant was administered the TAMV-I as part of a larger neuropsychological battery. Free recall, memory delay and recognition scores were normed using multiple linear regressions and standard deviations of residual values...
October 10, 2017: NeuroRehabilitation
https://www.readbyqxmd.com/read/29036848/concentration-endurance-test-d2-normative-data-for-spanish-speaking-pediatric-population
#4
D Rivera, C Salinas, D Ramos-Usuga, I D Delgado-Mejía, Y Vasallo Key, G P Hernández Agurcia, J Valencia Vásquez, C E García-Guerrero, C García de la Cadena, B V Rabago Barajas, I Romero-García, A I Campos Varillas, M Sánchez-SanSegundo, A Galvao-Carmona, L Lara, E J Granja Gilbert, P Martín-Lobo, J Velázquez-Cardoso, A Caracuel, J C Arango-Lasprilla
OBJECTIVE: To generate normative data for the Concentration Endurance Test (d2) test in Spanish-speaking pediatric populations. METHOD: The sample consisted of 4,373 healthy children from nine countries in Latin America (Chile, Cuba, Ecuador, Guatemala, Honduras, Mexico, Paraguay, Peru, and Puerto Rico) and Spain. Each participant was administered the d2 test as part of a larger neuropsychological battery. The Total number of items processed (TN), Total number of correct responses (CR), Total performance (TP), and Concentration performance (CP) scores were normed using multiple linear regressions and standard deviations of residual values...
October 8, 2017: NeuroRehabilitation
https://www.readbyqxmd.com/read/29036726/contribution-of-different-particles-measured-with-track-etched-detectors-onboard-iss
#5
I Ambrožová, M Davídková, K Pachnerová Brabcová, R V Tolochek, V A Shurshakov
Cosmic radiation consists of primary high-energy galactic and solar particles. When passing through spacecraft walls and astronauts' bodies, the spectrum becomes even more complex due to generating of secondary particles through fragmentation and nuclear interactions. Total radiation exposure is contributed by both these components. With an advantage, space research uses track etched detectors from the group of passive detectors visualizing the tracks of particles, in this case by etching. The detectors can discriminate between various components of cosmic radiation...
September 29, 2017: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/29036690/simultaneous-measurements-of-nanoaerosols-and-radioactive-aerosols-containing-the-short-lived-radon-isotopes
#6
P P S Otahal, I Burian, J Ondracek, V Zdimal, R F Holub
The activity size distribution of the Equilibrium-Equivalent Concentration (EER) of 222Rn is one of the most important parameters for the estimation of radiation dose by inhalation of radon decay products. A series of measurements of the EER activity size distribution were performed by the screen diffusion battery in Radon-Aerosol chamber (10 m3) at the National Institute for Nuclear, Chemical, and Biological Protection (SUJCHBO). These measurements were performed at different levels of radon concentration...
September 19, 2017: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/29036681/intra-specific-trends-of-lumen-and-wall-resistivities-of-vessels-within-the-stem-xylem-vary-among-three-woody-plants
#7
Hiroki Ooeda, Ichiro Terashima, Haruhiko Taneda
Water flow through xylem vessels encounters hydraulic resistance when passing through the vessel lumen and end wall. Comparative studies have reported that lumen and end wall resistivities co-limit water flow through stem xylem in several angiosperm woody species that have vessels of different average diameter and length. This study examined the intra-specific relationship between the lumen and end wall resistivities (Rlumen and Rwall) for vessels within the stem xylem using three deciduous angiosperm woody species found in temperate forest...
September 23, 2017: Tree Physiology
https://www.readbyqxmd.com/read/29036675/indoor-radon-thoron-and-their-progeny-concentrations-in-high-thoron-rural-serbia-environments
#8
Zora S Zunic, Z Stojanovska, N Veselinovic, R Mishra, I V Yarmoshenko, B K Sapra, T Ishikawa, Y Omori, Z Curguz, P Bossew, V Udovicic, R C Ramola
This article deals with the variation of radon (Rn), thoron (Tn) and their progeny concentrations expressed in terms of equilibrium equivalent concentrations (EERC and EETC), in 40 houses, in four villages of Sokobanja municipality, Southern Serbia. Two types of passive detectors were used: (1) discriminative radon-thoron detector for simultaneous Rn and Tn gases measurements and (2) direct Tn and Rn progeny sensors (DRPS/DTPS) for measuring Rn and Tn progeny concentrations. Detectors were exposed simultaneously for a single period of 12 months...
September 19, 2017: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/29036641/inverted-v-sign-subacute-combined-degeneration-of-the-spinal-cord
#9
Hiroki Matsuura, Tetsuya Nakamura
No abstract text is available yet for this article.
October 3, 2017: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/29036638/the-basic-tilted-helix-bundle-domain-of-the-prolyl-isomerase-fkbp25-is-a-novel-double-stranded-rna-binding-module
#10
David Dilworth, Santosh K Upadhyay, Pierre Bonnafous, Amiirah Bibi Edoo, Sarah Bourbigot, Francy Pesek-Jardim, Geoff Gudavicius, Jason J Serpa, Evgeniy V Petrotchenko, Christoph H Borchers, Christopher J Nelson, Cameron D Mackereth
Prolyl isomerases are defined by a catalytic domain that facilitates the cis-trans interconversion of proline residues. In most cases, additional domains in these enzymes add important biological function, including recruitment to a set of protein substrates. Here, we report that the N-terminal basic tilted helix bundle (BTHB) domain of the human prolyl isomerase FKBP25 confers specific binding to double-stranded RNA (dsRNA). This binding is selective over DNA as well as single-stranded oligonucleotides. We find that FKBP25 RNA-association is required for its nucleolar localization and for the vast majority of its protein interactions, including those with 60S pre-ribosome and early ribosome biogenesis factors...
September 25, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29036629/nanotechnology-a-promising-new-paradigm-for-the-control-of-pain
#11
Krishnan V Chakravarthy, Frank J Boehm, Paul J Christo
Objective: The objective of this article is to critically review both preclinical and clinical studies that focus on the use of nanotechnology for both acute and chronic pain management, surveying both diagnostic and therapeutic applications. The article also provides information on nanotechnology for pain practitioners, so that they may better understand how this technology works and how it may be applied to their day-to-day clinical practice. Study Design: Narrative review...
June 27, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29036622/comparison-between-padc-and-fntd-neutron-detector-systems-in-blind-tests
#12
E G Yukihara, M S Akselrod, V Fomenko, J Harrison, M Million, F Assenmacher, A Stabilini, K Meier
The objective of this study was to compare a neutron dosimetry system based on polyallyl diglycol carbonate (PADC) detectors with a new system based on Al2O3:C,Mg fluorescence nuclear track detectors (FNTD). The irradiations, performed as part of an intercomparison organized by the Physikalisch-Technische Bundesanstalt (PTB), Germany, were on a PMMA phantom with 252Cf or 241Am-Be source, usually with the phantom surface perpendicular to the radiation beam (0° angle), and with Hp(10) values between 0.3 and 7 mSv...
September 23, 2017: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/29036615/monitoring-of-cerebral-oximetry-during-head-up-tilt-test-in-adults-with-history-of-syncope-and-orthostatic-intolerance
#13
E Bachus, H Holm, V Hamrefors, O Melander, R Sutton, M Magnusson, A Fedorowski
Aims: We applied near-infrared-spectroscopy (NIRS) to measure absolute frontal cerebral tissue oxygen saturation (SctO2) during head-up tilt test (HUT) in patients investigated for unexplained syncope. Methods and results: Synchronized non-invasive beat-to-beat haemodynamic monitoring, ECG, SctO2 (NIRS; normal range: 60-80%), and peripheral oxygen saturation (left hand, SpO2) were applied during HUT in a random sample of patients with unexplained syncope. Tracings of 54 patients (mean-age: 55 ± 19 years, 39% male) with negative HUT, vasovagal syncope (VVS), or orthostatic hypotension (OH) were analysed...
September 28, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29036614/identification-of-a-candidate-mutation-in-the-col1a2-gene-of-a-chow-chow-with-osteogenesis-imperfecta
#14
E M Quist, R Doan, R R Pool, B F Porter, D L Bannasch, S V Dindot
Osteogenesis imperfecta (OI) is a genetic disease that occurs in humans and animals. Individuals with OI exhibit signs of extreme bone fragility and osteopenia with frequent fractures and perinatal lethality in severe cases. In this study, we report the clinical diagnosis of OI in a dog and the use targeted next-generation sequencing to identify a candidate autosomal dominant mutation in the COL1A2 gene. A five-month old male Chow Chow was examined with a fractured left humerus and resolving, bilateral femoral fractures...
September 19, 2017: Journal of Heredity
https://www.readbyqxmd.com/read/29036585/ambulatory-ph-impedance-pressure-monitoring-as-a-diagnostic-tool-for-the-reflux-cough-syndrome
#15
T V K Herregods, A Pauwels, J Jafari, D Sifrim, A J P M Smout, A J Bredenoord, J Tack
Gastroesophageal reflux is considered to be a significant contributing factor to chronic unexplained cough. Patients are often presumed to have reflux-induced cough and are exposed to high-dose and long-term empirical therapy with proton pump inhibitors (PPIs) despite the limited treatment efficacy in this population. We aimed to assess the diagnostic value of 24-hour ambulatory pH-impedance-pressure monitoring for the diagnosis of reflux-induced chronic cough. In this multicenter study, we evaluated 192 patients with chronic cough using 24-hour pH-impedance-pressure monitoring off PPIs...
September 27, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/29036575/peptides-of-the-variable-igg-domain-as-potential-biomarker-candidates-in-primary-open-angle-glaucoma-poag
#16
Carsten Schmelter, Natarajan Perumal, Sebastian Funke, Katharina Bell, Norbert Pfeiffer, Franz H Grus
Autoantibody profiling has gained increasing interest in the research field of glaucoma promising the detection of highly specific and sensitive marker candidates for future diagnostic purposes. Recent studies demonstrated that immune responses are characterized by the expression of congruent or similar complementarity determining regions (CDR) in different individuals and could be used as molecular targets in biomarker discovery. Main objective of this study was to characterize glaucoma-specific peptides from the variable region of sera-derived immunoglobulins using liquid chromatography - mass spectrometry (LC-MS) - based quantitative proteomics...
September 22, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/29036543/pilot-reported-beta-blockers-identified-by-forensic-toxicology-analysis-of-postmortem-specimens
#17
Dennis V Canfield, Kurt M Dubowski, James M Whinnery, Estrella M Forster
Introduction: This study compared beta-blockers reported by pilots with the medications found by postmortem toxicology analysis of specimens received from fatal aviation accidents between 1999 and 2015. Several studies have compared drugs using the standard approach: Compare the drug found by toxicology analysis with the drug reported by the pilot. This study uniquely examined first the pilot-reported medication and then compared it to that detected by toxicology analysis. This study will serve two purposes: (i) to determine the capability of a toxicology laboratory to detect reported medications, and (ii) to identify pilots with medications below detectable limits...
September 25, 2017: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/29036534/constitutive-phenolic-biomarkers-identify-na%C3%A3-ve-quercus-agrifolia-resistant-to-phytophthora-ramorum-the-causal-agent-of-sudden-oak-death
#18
Anna O Conrad, Brice A McPherson, David L Wood, Laurence V Madden, Pierluigi Bonello
Sudden oak death, caused by the invasive pathogen Phytophthora ramorum Werres, de Cock & Man in't Veld, can be deadly for Quercus agrifolia Neé (coast live oak, CLO). However, resistant trees have been observed in natural populations. The objective of this study was to examine if pre-attack (constitutive) levels of phenolic compounds can be used as biomarkers to identify trees likely to be resistant. Naïve trees were selected from a natural population and phloem was sampled for analysis of constitutive phenolics...
September 26, 2017: Tree Physiology
https://www.readbyqxmd.com/read/29036518/are-prothrombotic-mutations-a-time-to-event-risk-factor
#19
Branko V Tomic, Maja Z Gvozdenov, Iva B Pruner, Jelena M Simic, Mirjana K Kovac, Dragica P Radojkovic, Valentina J Djordjevic
Background: Deep vein thrombosis (DVT) represents a common disorder involving genetic and acquired risk factors. It has been proposed that acquired risk factors are more important with aging than genetic factors, indicating different prevalence of prothrombotic mutations throughout the lifespan. Objective: To determine the role of the most frequent prothrombotic genetic risk factors (Factor V [FV] Leiden and Factor II [FII] G20210A mutations) in first-time DVT etiology in patients of different ages...
September 23, 2017: Laboratory Medicine
https://www.readbyqxmd.com/read/29036508/a-novel-tepc-for-microdosimetry-at-nanometric-level-response-against-different-neutron-fields
#20
D Bortot, D Mazzucconi, M Bonfanti, S Agosteo, A Pola, S Pasquato, A Fazzi, P Colautti, V Conte
Tissue equivalent proportional counter (TEPC) is the most accurate device for measuring the microdosimetric properties of a particle beam, nevertheless no detailed information on the track structure of the impinging particles can be obtained, since the lower operation limit of common TEPCs is ~0.3 μm. On the other hand, the pattern of particle interactions at the nanometer level is measured by only three different nanodosimeters worldwide: practical instruments are not yet available. In order to partially fill the gap between microdosimetry and track-nanodosimetry, a low-pressure avalanche-confinement TEPC was recently designed and constructed for simulating tissue-equivalent sites down to the nanometric region...
September 29, 2017: Radiation Protection Dosimetry
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