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https://www.readbyqxmd.com/read/29471538/novel-roles-of-ascorbate-in-plants-induction-of-cytosolic-ca2-signals-and-efflux-from-cells-via-anion-channels
#1
M Makavitskaya, D Svistunenko, I Navaselsky, P Hryvusevich, V Mackievic, C Rabadanova, E Tyutereva, V Samokhina, D Straltsova, A Sokolik, O Voitsekhovskaja, V Demidchik
Ascorbate is not often considered as a signalling molecule in plants. This study demonstrates that, in Arabidopsis roots, exogenous L-ascorbic acid triggers a transient increase of the cytosolic free calcium activity ([Ca2+]cyt.) that is central to plant signalling. Exogenous copper and iron stimulates the ascorbate-induced [Ca2+]cyt. elevation while cation channel blockers, free radical scavengers, low extracellular [Ca2+], transition metal chelators and removal of the cell wall inhibit this reaction. These data show that apoplastic redox-active transition metals are involved in the ascorbate-induced [Ca2+]cyt...
February 17, 2018: Journal of Experimental Botany
https://www.readbyqxmd.com/read/29471514/management-of-anaemia-and-iron-deficiency-in-patients-with-cancer-esmo-clinical-practice-guidelines
#2
M Aapro, Y Beguin, C Bokemeyer, M Dicato, P Gascón, J Glaspy, A Hofmann, H Link, T Littlewood, H Ludwig, A Österborg, P Pronzato, V Santini, D Schrijvers, R Stauder, K Jordan, J Herrstedt
No abstract text is available yet for this article.
February 20, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29471496/should-acute-q-fever-patients-be-screened-for-valvulopathy-to-prevent-endocarditis
#3
Marit M A de Lange, Laura E V Gijsen, Cornelia C H Wielders, Wim van der Hoek, Arko Scheepmaker, Peter M Schneeberger
Background: Echocardiographic screening of acute Q-fever patients and antibiotic prophylaxis for patients with cardiac valvulopathy are considered an important approach to prevent chronic Q-fever-related endocarditis. During a large Q-fever epidemic in the Netherlands, routine screening echocardiography was discontinued, raising controversy in the international literature. We followed a cohort of acute Q-fever patients to estimate the risk for developing chronic Q-fever, and we evaluated the impact of screening in patients who were not yet known to have a valvulopathy...
February 20, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29471481/bacterial-fungal-interactions-ecology-mechanisms-and-challenges
#4
A Deveau, G Bonito, J Uehling, M Paoletti, M Becker, S Bindschedler, S Hacquard, V Hervé, J Labbé, O A Lastovetsky, S Mieszkin, L J Millet, B Vajna, P Junier, P Bonfante, B P Krom, S Olsson, J D van Elsas, L Y Wick
Fungi and bacteria are found living together in a wide variety of environments. Their interactions are significant drivers of many ecosystem functions and are important for the health of plants and animals. A large number of fungal and bacterial families are engaged in complex interactions that lead to critical behavioural shifts of the microorganisms ranging from mutualism to pathogenicity. The importance of bacterial-fungal interactions (BFI) in environmental science, medicine and biotechnology has led to the emergence of a dynamic and multidisciplinary research field that combines highly diverse approaches including molecular biology, genomics, geochemistry, chemical and microbial ecology, biophysics and ecological modelling...
February 19, 2018: FEMS Microbiology Reviews
https://www.readbyqxmd.com/read/29471469/effect-of-lemon-leaves-on-energy-and-c-n-balances-methane-emission-and-milk-performance-in-murciano-granadina-dairy-goats
#5
C Fernández, J V Marti, I Pérez-Baena, J L Palomares, C Ibáñez, J V Segarra
The objective of this experiment was to find out the effect of lemon leaves on energy and C-N balances, methane emission, and milk performance in dairy goats. Lemon leaves were used to replace alfalfa as forage in a diet for Murciano-Granadina goats. Ten Murciano-Granadina dairy goats (44.1 ± 4.47 kg of BW) in late lactation (185 ± 7.2 d) were selected in a crossover design experiment, where each goat received two treatments in 2 periods. One group was fed a mixed ration with 450 g of pelleted alfalfa/kg of DM (ALF diet) and, the other group replaced alfalfa with 450 g of pelleted lemon leaves/kg DM (LEM diet)...
February 17, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29471451/genomic-evidence-of-widespread-admixture-from-polar-bears-into-brown-bears-during-the-last-ice-age
#6
James A Cahill, Peter D Heintzman, Kelley Harris, Matthew D Teasdale, Joshua Kapp, André E Rodrigues Soares, Ian Stirling, Daniel Bradley, Ceiridwen J Edwards, Kiley Graim, Aliaksandr A Kisleika, Alexander V Malev, Nigel Monaghan, Richard E Green, Beth Shapiro
Recent genomic analyses have provided substantial evidence for past periods of gene flow from polar bears (Ursus maritimus) into Alaskan brown bears (Ursus arctos), with some analyses suggesting a link between climate change and genomic introgression. However, because it has mainly been possible to sample bears from the present day, the timing, frequency, and evolutionary significance of this admixture remains unknown. Here, we analyze genomic DNA from three additional and geographically distinct brown bear populations, including two that lived temporally close to the peak of the last ice age...
February 20, 2018: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/29471444/relation-of-sex-hormone-levels-with-prevalent-and-10-year-change-in-aortic-distensibility-assessed-by-mri-the-multi-ethnic-study-of-atherosclerosis
#7
V Subramanya, B Ambale-Venkatesh, Y Ohyama, D Zhao, C C Nwabuo, W S Post, E Guallar, P Ouyang, S J Shah, M A Allison, C E Ndumele, D Vaidya, D A Bluemke, J A Lima, E D Michos
Background: Women experience a steeper decline in aortic elasticity related to aging compared to men. We examined whether sex hormone levels were associated with ascending aortic distensibility (AAD) in the Multi-Ethnic Study of Atherosclerosis. Methods: We studied 1,345 post-menopausal women and 1,532 men aged 45-84 years, who had serum sex hormone levels, AAD measured by phase-contrast cardiac magnetic resonance imaging, and ejection fraction>50% at baseline...
February 19, 2018: American Journal of Hypertension
https://www.readbyqxmd.com/read/29471418/skin-specific-training-experience-of-workers-assessed-for-contact-dermatitis
#8
B Zack, V Arrandale, D L Holness
Background: Contact dermatitis is a common and preventable work-related disease. Skin-specific training may be effective for preventing occupational contact dermatitis, but little information is available regarding actual workplace training and its effectiveness. Aims: To describe workplace skin-specific training among workers with suspected contact dermatitis. Methods: Patch test patients being assessed for suspected contact dermatitis at an occupational health clinic in Toronto, Canada, completed a questionnaire on training experiences, workplace characteristics, exposures and skin protection practices...
February 17, 2018: Occupational Medicine
https://www.readbyqxmd.com/read/29471416/anti-interleukin-6-receptor-tocilizumab-in-refractory-uveitis-associated-with-beh%C3%A3-et-s-disease-multicentre-retrospective-study
#9
Belén Atienza-Mateo, Vanesa Calvo-Río, Emma Beltrán, Lucía Martínez-Costa, Elia Valls-Pascual, Marisa Hernández-Garfella, Antonio Atanes, Miguel Cordero-Coma, Joan Miquel Nolla, Carmen Carrasco-Cubero, Javier Loricera, María C González-Vela, Nuria Vegas-Revenga, Carlos Fernández-Díaz, Rosalía Demetrio-Pablo, Lucía C Domínguez-Casas, José Luis Martín-Varillas, Natalia Palmou-Fontana, José L Hernández, Miguel Á González-Gay, Ricardo Blanco
Objective: To assess the efficacy of tocilizumab (TCZ) in refractory uveitis of Behçet's disease (BD). Methods: Multicentre study of patients with BD-associated uveitis. Patients were refractory to conventional and biologic immunosuppressive drugs. The main outcome measures were intraocular inflammation, macular thickness, visual acuity and corticosteroid-sparing effects. Results: We studied 11 patients (7 men) (20 affected eyes); median age 35 years...
February 19, 2018: Rheumatology
https://www.readbyqxmd.com/read/29471404/the-war-on-the-placenta-the-differing-battles-of-high-fat-diet-and-obesity
#10
Angela Odle, Melody Allensworth-James, Gwen V Childs
No abstract text is available yet for this article.
February 20, 2018: Endocrinology
https://www.readbyqxmd.com/read/29471395/origin-and-composition-of-cell-free-dna-in-spent-medium-from-human-embryo-culture-during-preimplantation-development
#11
M Vera-Rodriguez, A Diez-Juan, J Jimenez-Almazan, S Martinez, R Navarro, V Peinado, A Mercader, M Meseguer, D Blesa, I Moreno, D Valbuena, C Rubio, C Simon
STUDY QUESTION: What is the origin and composition of cell-free DNA in human embryo spent culture media? SUMMARY ANSWER: Cell-free DNA from human embryo spent culture media represents a mix of maternal and embryonic DNA, and the mixture can be more complex for mosaic embryos. WHAT IS KNOWN ALREADY: In 2016, ~300 000 human embryos were chromosomally and/or genetically analyzed using preimplantation genetic testing for aneuploidies (PGT-A) or monogenic disorders (PGT-M) before transfer into the uterus...
February 20, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29471351/viability-of-campylobacter-spp-in-frozen-and-chilled-broiler-carcasses-according-to-real-time-pcr-with-propidium-monoazide-pretreatment
#12
Andréa G S A Castro, Elaine M S Dorneles, Ethiene L S Santos, Telma M Alves, Guilherme R Silva, Tadeu C Figueiredo, Débora C S Assis, Andrey P Lage, Silvana V Cançado
The aim of this study was to evaluate the viability of Campylobacter spp. in frozen and chilled broiler carcasses using real-time PCR with propidium monoazide (PMA) pretreatment. Sixty broiler carcasses were collected: 30 frozen and 30 chilled. Each carcass was submitted to 2 real-time PCR protocols to detect and quantify Campylobacter spp.: one using pretreatment with PMA, which blocks the amplification of DNA from dead bacteria, and the other without PMA. The results showed that PMA-pretreated carcasses, either frozen or chilled, had a lower positivity rate compared to untreated samples (P < 0...
February 19, 2018: Poultry Science
https://www.readbyqxmd.com/read/29471333/genomic-dissection-of-enhancers-uncovers-principles-of-combinatorial-regulation-and-cell-type-specific-wiring-of-enhancer-promoter-contacts
#13
Verena Thormann, Maika C Rothkegel, Robert Schöpflin, Laura V Glaser, Petar Djuric, Na Li, Ho-Ryun Chung, Kevin Schwahn, Martin Vingron, Sebastiaan H Meijsing
No abstract text is available yet for this article.
February 19, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/29471189/concentrations-of-trace-elements-and-pcdd-fs-around-a-municipal-solid-waste-incinerator-in-girona-catalonia-spain-human-health-risks-for-the-population-living-in-the-neighborhood
#14
Joaquim Rovira, Martí Nadal, Marta Schuhmacher, José L Domingo
Previously to the modernization of the municipal solid waste incinerator (MSWI) of Campdorà (Girona, Catalonia, Spain) two sampling campaigns (2015 and 2016) were conducted. In each campaign, 8 soil and 4 air samples (PM10 and total particle phase and gas phase) were collected. The levels of As, Cd, Co, Cr, Cu, Hg, Mn, Ni, Pb, Sb, Sn, Tl and V, and PCDD/Fs were analysed at different distances and wind directions around the MSWI. Environmental levels of trace elements and PCDD/Fs were used to assess exposure and health risks (carcinogenic and non-carcinogenic) for the population living around the facility...
February 19, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29471188/developing-cross-validating-and-applying-regression-models-to-predict-the-concentrations-of-faecal-indicator-organisms-in-coastal-waters-under-different-environmental-scenarios
#15
Robson V de Souza, Carlos J A Campos, Luis H P Garbossa, Walter Q Seiffert
This study developed, cross-validated and applied a regression-based model to predict concentrations of faecal indicator organisms (FIOs) under different environmental conditions in the North and South bays of Santa Catarina, South of Brazil. The model was developed using a database of FIO concentrations in seawater sampled at 50 sites and the validation was performed using a different database by comparing 288 pairs of measured and modelled results for 15 sites. The index of agreement between the model outputs and the FIO concentrations measured during the validation period was 66%; the mean average error was 0...
February 19, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29471173/correlating-growth-mechanism-and-morphology-in-cu-tcnq-organometallic-complex-a-microscopic-study
#16
Gopala R Bhadu, Jayesh C Chaudhari, Babulal Rebary, Rajesh Patidar, Divesh N Srivastava
The structure-property correlation in the Cu-TCNQ organometallic complex is very important for explaining its unusual electrical, optical and magnetic properties. Consequently several morphological studies and their correlation with the properties of these materials can be found in the literature, although no systematic study of various morphologies with growth conditions and their correlation has been reported to the best of our knowledge. Therefore in this manuscript the interconversion of various morphologies is reported using electron and probe microscopies...
February 13, 2018: Micron: the International Research and Review Journal for Microscopy
https://www.readbyqxmd.com/read/29471163/capacity-and-recycling-of-polyoxometalate-applied-in-as-iii-oxidation-by-fe-ii-amended-zero-valent-aluminum
#17
Liang-Ching Hsu, Yen-Lin Cho, Yu-Ting Liu, Yu-Min Tzou, Heng Yi Teah
Arsenic remediation is often initiated by oxidizing As(III) to As(V) to alleviate its toxicity and mobility. Due to the easy availability, zero-valent Al (ZVAl) like Al can was considered as potential alternatives to facilitate As(III) oxidation. This study determined the capability and recycling of polyoxometalate (POM) to catalyze As(III) oxidation in Fe(II)-amended ZVAl systems. POM acquired electrons from ZVAl more effectively at pH 1 than at pH 2. While 76% of the reduced POM [POM(e- )] reacted with O2(g) to generate H2 O2 at pH 1, only 60% of POM(e- ) was used to produce H2 O2 at pH 2...
February 12, 2018: Chemosphere
https://www.readbyqxmd.com/read/29471147/blue-light-versus-red-light-for-photodynamic-therapy-of-basal-cell-carcinoma-in-patients-with-gorlin-syndrome-a-bilaterally-controlled-comparison-study
#18
Edward V Maytin, Urvashi Kaw, Muneeb Ilyas, Judith A Mack, Bo Hu
BACKGROUND: Photodynamic therapy (PDT) is a non-scarring alternative for treating basal cell carcinoma (BCC) in patients with Basal Cell Nevus Syndrome (BCNS), also known as Gorlin syndrome. In Europe, red light (635 nm) is the predominant source for PDT, whereas in the United States blue light (400 nm) is more widely available. The objective of this study was to conduct a head-to-head comparison of blue light and red light PDT in the same BCNS patients. METHODS: In a pilot study of three patients with 141 BCC lesions, 5-aminolevulinate (20% solution) was applied to all tumors...
February 19, 2018: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29471095/proteomic-of-goat-milk-whey-and-its-bacteriostatic-and-antitumour-potential
#19
Gracy K V V Medeiros, Rita C R E Queiroga, Whyara K A Costa, Carlos A A Gadelha, Rodrigo R E Lacerda, José T J G Lacerda, Luciano S Pinto, Elizandra Braganhol, Fernanda C Teixeira, Paula P de S Barbosa, Maria I F Campos, Gregório F Gonçalves, Hilzeth L F Pessôa, Tatiane S Gadelha
Goat whey is normally discarded in the milk processing industry. However, several studies have addressed its biological properties and possible use in human or animal diet. The present study aimed to analysis the protein profile of goat whey to evaluate its possible oxidant, antioxidant, antibacterial, antitumour, and cytotoxic activities in vitro against human erythrocytes. Goat whey was skimmed, and crude protein extract (CPE) was obtained. Next, protein fractions (F) were obtained using ammonium sulphate precipitation method...
February 19, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29471086/gastroprotective-effect-of-ethanol-extracts-of-cladodes-and-roots-of-pilosocereus-gounellei-a-weber-ex-k-schum-bly-ex-rowl-cactaceae-on-experimental-ulcer-models
#20
Glaubert A Sousa, Irisdalva S Oliveira, Francilene V Silva-Freitas, Ana Flávia S C Viana, Benedito P S Neto, Francisco Valmor M Cunha, Rodrigo L G Gonçalves, Antônio Carlos M Lima Filho, Maurício P M Amaral, Rita de Cássia M Oliveira, Pedro D Fernandes, Jéssica K S Maciel, Tânia Maria S da Silva, Maria de Fátima V Souza, Francisco A Oliveira
ETHNOPHARMACOLOGICAL RELEVANCE: Pilosocereus gounellei Cactaceae), popularly known as "xique xique", is a species native from Caatinga region of Northeast Brazil, which is used by traditional communities in folk medicine for a variety of health problems, especially inflammatory processes and gastritis. AIM OF THE STUDY: The present study investigates the possible gastric antiulceractivity of ethanol extracts obtained from the cladodes and roots of Pilosocereus gounellei (EECPG and EERPG, respectively) and mechanisms of action underlying this effect...
February 19, 2018: Journal of Ethnopharmacology
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