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https://www.readbyqxmd.com/read/27933744/neurolaw-and-banks-v-goodfellow-1870-guidance-for-the-assessment-of-testamentary-capacity-today
#1
Hayley Bennett
No abstract text is available yet for this article.
December 2016: Australasian Journal on Ageing
https://www.readbyqxmd.com/read/27933733/mannich-bases-of-1-2-4-triazole-3-thione-containing-adamantane-moiety-synthesis-preliminary-anticancer-evaluation-and-molecular-modeling-studies
#2
Milorad Z Milošev, Katarina Jakovljević, Milan D Joksović, Tatjana Stanojković, Ivana Z Matić, Milka Perović, Vesna Tešić, Selma Kanazir, Milan Mladenović, Marko V Rodić, Vukadin M Leovac, Snežana Trifunović, Violeta Marković
A series of 18 novel N-Mannich bases derived from 5-adamantyl-1,2,4-triazole-3-thione was synthesized and characterized using NMR spectroscopy and X-ray diffraction technique. All derivatives were evaluated for their anticancer potential against four human cancer cell lines. Several tested compounds exerted good cytotoxic activities on K562 and HL-60 cell lines, along with pronounced selectivity, showing lower cytotoxicity against normal fibroblasts MRC-5 compared to cancer cells. The effects of compounds 5b, 5e and 5j on the cell cycle were investigated by flow cytometric analysis...
December 9, 2016: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/27933647/whole-woman-s-health-v-hellerstedt-and-the-current-implications-for-abortion-access
#3
Y Tony Yang, Katy B Kozhimannil
No abstract text is available yet for this article.
December 9, 2016: Birth
https://www.readbyqxmd.com/read/27933635/vietnamese-version-of-diabetes-self-management-instrument-development-and-psychometric-testing
#4
Tiet-Hanh Dao-Tran, Debra J Anderson, Anne M Chang, Charrlotte Seib, Cameron Hurst
Self-management plays a vital role in diabetes management for adults with type 2 diabetes (T2DM). While there are many people with T2DM in Vietnam, clinical understanding of diabetes self-management (DSM) in this context is limited due to the lack of a valid measurement instrument. Translation and back-translation processes were used to translate the Diabetes Self-Management Instrument (DSMI) into Vietnamese. Then, translation equivalence, face validity, construct validity, and internal consistency were assessed in a sample of 198 Vietnamese adults with T2DM...
December 9, 2016: Research in Nursing & Health
https://www.readbyqxmd.com/read/27933594/vegetable-peel-waste-for-the-production-of-zno-nanoparticles-and-its-toxicological-efficiency-antifungal-hemolytic-and-antibacterial-activities
#5
T V Surendra, Selvaraj Mohana Roopan, Naif Abdullah Al-Dhabi, Mariadhas Valan Arasu, Gargi Sarkar, K Suthindhiran
Zinc oxide (ZnO) nanoparticles (NPs) are important materials when making different products like sun screens, textiles, and paints. In the current study, the photocatalytic effect of prepared ZnO NPs from Moringa oleifera (M. oleifera) was evaluated on degradation of crystal violet (CV) dye, which is largely released from textile industries and is harmful to the environment. Preliminarily, ZnO NP formation was confirmed using a double beam ultraviolet visible (UV-Vis) spectrophotometer; further, the NP size was estimated using XRD analysis and the functional group analysis was determined using Fourier transform infrared (FT-IR) spectroscopy...
December 2016: Nanoscale Research Letters
https://www.readbyqxmd.com/read/27933548/metabolic-characterization-of-acutely-isolated-hippocampal-and-cerebral-cortical-slices-using-u-13-c-glucose-and-1-2-13-c-acetate-as-substrates
#6
Laura F McNair, Rasmus Kornfelt, Anne B Walls, Jens V Andersen, Blanca I Aldana, Jakob D Nissen, Arne Schousboe, Helle S Waagepetersen
Brain slice preparations from rats, mice and guinea pigs have served as important tools for studies of neurotransmission and metabolism. While hippocampal slices routinely have been used for electrophysiology studies, metabolic processes have mostly been studied in cerebral cortical slices. Few comparative characterization studies exist for acute hippocampal and cerebral cortical slices, hence, the aim of the current study was to characterize and compare glucose and acetate metabolism in these slice preparations in a newly established incubation design...
December 8, 2016: Neurochemical Research
https://www.readbyqxmd.com/read/27933514/changes-in-cardiac-repolarisation-during-spontaneous-nocturnal-hypoglycaemia-in-subjects-with-type-1-diabetes-a-preliminary-report
#7
Minna L Koivikko, Tuomas Kenttä, Pasi I Salmela, Heikki V Huikuri, Juha S Perkiömäki
AIMS: Experimental studies have revealed that hypoglycaemia can result in morphological changes in electrocardiographic repolarisation in subjects with type 1 diabetes. However, the influence of spontaneous nocturnal hypoglycaemia on repolarisation morphology in a 'real life' situation is not clear. METHODS: Adults with type 1 diabetes (n = 11) underwent continuous glucose monitoring with a subcutaneous sensor and digital 12-lead ECG recording for three nights...
December 8, 2016: Acta Diabetologica
https://www.readbyqxmd.com/read/27933490/alterations-in-the-cerebral-microvascular-proteome-expression-profile-after-transient-global-cerebral-ischemia-in-rat
#8
Stine Spray, Sara E Johansson, Alistair V G Edwards, Martin R Larsen, Aneta Radziwon-Balicka, Gro K Povlsen, Lars Edvinsson
This study aimed at obtaining an in-depth mapping of expressional changes of the cerebral microvasculature after transient global cerebral ischemia (GCI) and the impact on these GCI-induced expressional changes of post-GCI treatment with a mitogen-activated protein kinase kinase (MEK1/2) inhibitor. GCI was induced in male Wistar rats followed by treatment with either vehicle or the MEK1/2 inhibitor U0126 every 12 h post-GCI. Seventy-two hours after GCI or sham surgery, the cerebral microvasculature was isolated and the protein content analysed with state-of-the-art mass spectrometry...
December 8, 2016: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/27933477/impact-of-low-energy-ct-imaging-on-selection-of-positive-oral-contrast-media-concentration
#9
Manuel Patino, Diana J Murcia, Andrea Prochowski Iamurri, Avinash R Kambadakone, Peter F Hahn, Dushyant V Sahani
OBJECTIVES: To determine to what extent low-energy CT imaging affects attenuation of gastrointestinal tract (GIT) opacified with positive oral contrast media (OCM). Second, to establish optimal OCM concentrations for low-energy diagnostic CT exams. METHODS: One hundred patients (38 men and 62 women; age 62 ± 11 years; BMI 26 ± 5) with positive OCM-enhanced 120-kVp single-energy CT (SECT), and follow-up 100-kVp acquisitions (group A; n = 50), or 40-70-keV reconstructions from rapid kV switching-single-source dual-energy CT (ssDECT) (group B; n = 50) were included...
December 8, 2016: Abdominal Radiology
https://www.readbyqxmd.com/read/27933456/penicillin-v-acylases-from-gram-negative-bacteria-degrade-n-acylhomoserine-lactones-and-attenuate-virulence-in-pseudomonas-aeruginosa
#10
Avinash Vellore Sunder, Putri Dwi Utari, Sureshkumar Ramasamy, Ronald van Merkerk, Wim Quax, Archana Pundle
Virulence pathways in gram-negative pathogenic bacteria are regulated by quorum sensing mechanisms, through the production and sensing of N-acylhomoserine lactone (AHL) signal molecules. Enzymatic degradation of AHLs leading to attenuation of virulence (quorum quenching) could pave the way for the development of new antibacterials. Penicillin V acylases (PVAs) belong to the Ntn hydrolase superfamily, together with AHL acylases. PVAs are exploited widely in the pharmaceutical industry, but their role in the natural physiology of their native microbes is not clearly understood...
December 8, 2016: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/27933447/indian-summer-heat-wave-of-2015-a-biometeorological-analysis-using-half-hourly-automatic-weather-station-data-with-special-reference-to-andhra-pradesh
#11
M A Sarath Chandran, A V M Subba Rao, V M Sandeep, V P Pramod, P Pani, V U M Rao, V Visha Kumari, Ch Srinivasa Rao
Heat wave is a hazardous weather-related extreme event that affects living beings. The 2015 summer heat wave affected many regions in India and caused the death of 2248 people across the country. An attempt has been made to quantify the intensity and duration of heat wave that resulted in high mortality across the country. Half hourly Physiologically Equivalent Temperature (PET), based on a complete heat budget of human body, was estimated using automatic weather station (AWS) data of four locations in Andhra Pradesh state, where the maximum number of deaths was reported...
December 8, 2016: International Journal of Biometeorology
https://www.readbyqxmd.com/read/27933331/characterization-of-arsenic-biotransformation-by-a-typical-bryophyte-physcomitrella-patens
#12
Xixiang Yin, Lihong Wang, Yifei Liu, Tenglong Jiang, Jianwei Gao
Arsenic (As) is a ubiquitous environmental toxin that has created catastrophic human health and environmental problems around world. Physcomitrella patens is a potential model plant for the study of environmental monitoring, which exists in all kinds of ecosystems. In this study, arsenic metabolism was investigated by this moss. When supplied with different levels of arsenate (50, 100, 200 µmol/L) for a 4-week period, the total arsenic concentrations were up to 231.4-565.4 mg/kg DW in this moss. Arsenite concentration increased with increasing external arsenate concentrations, the proportion was up to 25...
December 8, 2016: Bulletin of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/27933282/myocardial-perfusion-scintigraphy-dosimetry-optimal-use-of-spect-and-spect-ct-technologies-in-stress-first-imaging-protocol
#13
REVIEW
M Lecchi, S Malaspina, C Scabbio, V Gaudieri, A Del Sole
PURPOSE: Over the past decade, nuclear medicine experts have been seeking to minimize patient exposure to radiation in myocardial perfusion scintigraphy (MPS). This review describes the latest technological innovations in MPS, particularly with regard to dose reduction. METHODS: We searched in PubMed for original clinical papers in English, published after 2008, using the following research criteria: (dose) and ((reduction) or (reducing)) and ((myocardial) or (cardiac) or (heart)) and ((nuclear medicine) or (nuclear imaging) or (radionuclide) or (scintigraphy) or (SPET) or (SPECT))...
2016: Clinical and Translational Imaging: Reviews in Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27933277/lectins-from-synadenium-carinatum-scll-and-artocarpus-heterophyllus-artinm-are-able-to-induce-beneficial-immunomodulatory-effects-in-a-murine-model-for-treatment-of-toxoplasma-gondii-infection
#14
Eliézer L P Ramos, Silas S Santana, Murilo V Silva, Fernanda M Santiago, Tiago W P Mineo, José R Mineo
Infection by Toxoplasma gondii affects around one-third of world population and the treatment for patients presenting toxoplasmosis clinically manifested disease is mainly based by a combination of sulfadiazine, pyrimethamine, and folinic acid. However, this therapeutic protocol is significantly toxic, causing relevant dose-related bone marrow damage. Thus, it is necessary to improve new approaches to investigate the usefulness of more effective and non-toxic agents for treatment of patients with toxoplasmosis...
2016: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/27933246/a-quantitative-report-on-the-impact-of-chloride-on-the-kinetic-coefficients-of-auxin-induced-growth-a-numerical-contribution-to-the-acid-growth-hypothesis
#15
Mariusz Pietruszka, Aleksandra Haduch-Sendecka
This work presents the application of several our own novel methods of analysing the kinetics of plant growth, which create, among others, a common platform for the comparison of experimental results. A relatively simple formula is used to parameterize the wide range of data that has been obtained for Zea mays L. in the literature, though it can also be used for different species. A biophysical/biochemical interpretation of the parameters was obtained from a theoretical model that is based on a modified Lockhart equation...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27933222/endophthalmitis-prophylaxis-using-a-single-drop-of-thermoresponsive-controlled-release-microspheres-loaded-with-moxifloxacin-in-a-rabbit-model
#16
Alex Mammen, Eric G Romanowski, Morgan V Fedorchak, Deepinder K Dhaliwal, R M Shanks, Regis P Kowalski
PURPOSE: Postsurgical endophthalmitis is a sight-threatening problem. We introduce a simple approach by using a single application of thermoresponsive controlled-release microspheres, loaded with moxifloxacin, to prevent bacterial endophthalmitis in a rabbit endophthalmitis prevention model. METHODS: We separated 24 rabbits into 3 treatment groups in which topical drop treatment was placed onto the conjunctival cul-de-sac: (1) a single drop of controlled-release microspheres containing moxifloxacin, (2) a single drop of controlled-release microspheres without moxifloxacin, and (3) multiple topical treatment with moxifloxacin alone every 15 minutes for 1 hour...
December 2016: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/27933210/educational-needs-of-health-professionals-working-in-rheumatology-in-europe
#17
Theodora P M Vliet Vlieland, Cornelia H M van den Ende, Francoise Alliot-Launois, Catherine Beauvais, Milena Gobbo, Annamaria Iagnocco, Ingrid E Lundberg, Pedro V Munuera-Martínez, Christina H Opava, Yeliz Prior, Anthony Redmond, Hana Smucrova, Dieter Wiek
OBJECTIVE: To explore the availability of postgraduate education for health professionals (HPs) working in rheumatology in Europe, and their perceived educational needs and barriers for participation in current educational offerings. METHODS: Structured interviews were conducted with national representatives of rheumatology HPs' organisations and an online survey among individual HPs was disseminated through existing European League Against Rheumatism (EULAR) networks (10 languages including English)...
2016: RMD Open
https://www.readbyqxmd.com/read/27933201/association-between-metabolic-syndrome-and-liver-histology-among-nafld-patients-without-diabetes
#18
Pushpjeet Kanwar, James E Nelson, Katherine Yates, David E Kleiner, Aynur Unalp-Arida, Kris V Kowdley
BACKGROUND: Metabolic syndrome (MetS) and obesity are associated with non-alcoholic fatty liver disease (NAFLD). The aim of this observational study was to examine the relationship of MetS and a diagnosis of non-alcoholic steatohepatitis (NASH) in patients without diabetes in the NASH Clinical Research Network (CRN). METHODS: Clinical, demographic, histological, laboratory and anthropometric data were collected on 356 adult patients without diabetes with NAFLD. Obesity was defined as body mass index ≥30...
2016: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/27933192/randomised-comparison-of-drug-eluting-versus-bare-metal-stenting-in-patients-with-non-st-elevation-myocardial-infarction
#19
Wouter S Remkes, Erik A Badings, Renicus S Hermanides, Saman Rasoul, Jan-Henk E Dambrink, Petra C Koopmans, Salem Hk The, Jan Paul Ottervanger, A T Marcel Gosselink, Jan Ca Hoorntje, Harry Suryapranata, Arnoud Wj van 't Hof
OBJECTIVE: The superiority of drug-eluting stents (DES) over bare-metal stents (BMS) in patients with ST elevation myocardial infarction (STEMI) is well studied; however, randomised data in patients with non-ST elevation myocardial infarction (NSTEMI) are lacking. The objective of this study was to investigate whether stenting with everolimus-eluting stents (EES) safely reduces restenosis in patients with NSTEMI as compared to BMS. METHODS: ELISA-3 patients were asked to participate in the angiographic substudy and were randomised to DE (Xience V) or BM (Vision) stenting (ELISA-3 group)...
2016: Open Heart
https://www.readbyqxmd.com/read/27933184/coxsackie-adenovirus-receptor-expression-is-enhanced-in-pancreas-from-patients-with-type-1-diabetes
#20
M Hodik, M Anagandula, J Fuxe, L Krogvold, K Dahl-Jørgensen, H Hyöty, L Sarmiento, G Frisk
OBJECTIVES: One of the theories connecting enterovirus (EV) infection of human islets with type 1 diabetes (T1D) is the development of a fertile field in the islets. This implies induction of appropriate proteins for the viral replication such as the coxsackie-adenovirus receptor (CAR). The aim of this study was to investigate to what extent CAR is expressed in human islets of Langerhans, and what conditions that would change the expression. DESIGN: Immunohistochemistry for CAR was performed on paraffin-embedded pancreatic tissue from patients with T1D (n=9 recent onset T1D, n=4 long-standing T1D), islet autoantibody-positive individuals (n=14) and non-diabetic controls (n=24) individuals...
2016: BMJ Open Diabetes Research & Care
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