Vitalie Vacaras, Andreea-Cristina Paraschiv, Silvina Iluț, Cristiana Vacaras, Cristina Nistor, Gheorghe-Eduard Marin, Andra Maria Schiopu, Dorian-Traian Nistor, Ștefan Cristian Vesa, Dafin Fior Mureșanu
Multiple sclerosis (MS) is a demyelinating central nervous system disease that leads to neurological disability. Brain-derived neurotrophic factors (BDNFs) are neurotrophins involved in neurodegenerative disorders. This study analysed the relationship between serum BDNF, neurological disability and different MS treatments. We included 63 people with MS (PwMS), with relapsing-remitting MS or clinically isolated syndrome, and 16 healthy controls (HCs). We analysed the serum levels of BDNF and MS specific disability tests (Expanded Disability Status Scale, timed 25-foot walk test, nine-hole peg test), at baseline (V0) and after one year of interferon beta1a or teriflunomide treatment (V1)...
February 29, 2024: Brain Sciences