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Protocol for preterm labor

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https://www.readbyqxmd.com/read/28570658/estimation-of-preterm-labor-immediacy-by-nonlinear-methods
#1
Iker Malaina, Luis Martinez, Roberto Matorras, Carlos Bringas, Larraitz Aranburu, Luis Fernández-Llebrez, Leire Gonzalez, Itziar Arana, Martín-Blas Pérez, Ildefonso Martínez de la Fuente
Preterm delivery affects about one tenth of human births and is associated with an increased perinatal morbimortality as well as with remarkable costs. Even if there are a number of predictors and markers of preterm delivery, none of them has a high accuracy. In order to find quantitative indicators of the immediacy of labor, 142 cardiotocographies (CTG) recorded from women consulting because of suspected threatened premature delivery with gestational ages comprehended between 24 and 35 weeks were collected and analyzed...
2017: PloS One
https://www.readbyqxmd.com/read/28484835/effectiveness-of-the-contemporary-treatment-of-preterm-labor-a-comparison-with-a-historical-cohort
#2
Philipp Wagner, Jiri Sonek, Harald Abele, Loefler Sarah, Markus Hoopmann, Sara Brucker, Qinging Wu, Karl Oliver Kagan
OBJECTIVE: To compare the effectiveness of contemporary treatment of preterm labor to a historical cohort. STUDY DESIGN: Retrospective matched case-control study to compare the outcomes of patients that were treated for preterm labor at the University Hospital of Tuebingen, Germany in 2014/2015 (current treatment cohort) and 2006/2007 (historical cohort). The study included women with singleton gestations who were admitted with the diagnosis of preterm labor between 24 + 0 and 34 + 0 weeks' gestation and a cervical length of ≤15 mm...
July 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28389222/cesarean-delivery-in-the-second-stage-of-labor-and-the-risk-of-subsequent-premature-birth
#3
Stephen L Wood, Selphee Tang, Susan Crawford
BACKGROUND: Cesarean delivery is being increasingly used by obstetricians for indicated deliveries in the second stage of labor. Unplanned extension of the uterine incision involving the cervix often occurs with these surgeries. Therefore, we hypothesized that cesarean delivery in the second stage of labor may increase the rate of subsequent spontaneous premature birth. OBJECTIVE: We sought to determine if cesarean delivery in the late first stage of labor or in the second stage of labor increases the risk of a subsequent spontaneous preterm birth...
April 4, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27642169/comparison-of-perinatal-outcomes-between-long-term-and-short-term-use-of-tocolytic-agent-a-historical-cohort-study-in-a-single-perinatal-hospital
#4
COMPARATIVE STUDY
Masamitsu Nakamura, Junichi Hasegawa, Tatsuya Arakaki, Shoko Hamada, Hiroko Takita, Tomohiro Oba, Keiko Koide, Ryu Matsuoka, Akihiko Sekizawa
AIM: The aim of this study was to evaluate the effect of long-term use of tocolytic agents to prevent preterm delivery and improve perinatal outcome. METHODS: A historical cohort study was performed in a single perinatal center. The maternal characteristics, frequency of preterm labor and prescribed dose of tocolytic agents were compared before and after changing the management protocol for threatened premature delivery. RESULTS: A total of 1548 deliveries were carried out before changing the protocol for the use of tocolytic agents for threatened premature delivery and 1444 deliveries afterwards...
December 2016: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/27581467/incidence-of-intrapartum-stillbirth-and-associated-risk-factors-in-tertiary-care-setting-of-nepal-a-case-control-study
#5
COMPARATIVE STUDY
Ashish Kc, Johan Wrammert, Uwe Ewald, Robert B Clark, Jageshwor Gautam, Gehanath Baral, Kedar P Baral, Mats Målqvist
BACKGROUND: Each year, 1.2 million intrapartum stillbirths occur globally. In Nepal, about 50 % of the total number of stillbirths occur during the intrapartum period. An understanding of the risk factors associated with intrapartum stillbirth will facilitate the development of preventative strategies to reduce the associated burden of death. This study was conducted in a tertiary-care setting with the aim to identify risk factors associated with intrapartum stillbirth. METHODS: A case-control study was completed from July 2012 to September 2013...
August 31, 2016: Reproductive Health
https://www.readbyqxmd.com/read/27555319/maternofetal-pharmacokinetics-and-fetal-lung-responses-in%C3%A2-chronically-catheterized-sheep-receiving-constant-low-dose-infusions-of-betamethasone-phosphate
#6
Matthew W Kemp, Masatoshi Saito, Haruo Usuda, Timothy J Molloy, Yuichiro Miura, Shinichi Sato, Shimpei Watanabe, Michael Clarke, Michael Fossler, Augusto Scmidt, Suhas G Kallapur, Boris W Kramer, John P Newnham, Alan H Jobe
BACKGROUND: Antenatal steroids are standard of care for cases of anticipated preterm labor to improve neonatal outcomes. However, steroids are potent drugs, and their use in pregnancy remains largely unoptimized. OBJECTIVE: The objective of the study was to measure the maternofetal pharmacokinetics of constant, low-dose intravenous betamethasone phosphate infusions and correlate these data with the transcriptional effect exerted by subclinical betamethasone exposures on the ovine fetal lung...
December 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27388033/comparison-of-rapid-bedside-tests-for-phosphorylated-insulin-like-growth-factor-binding-protein-1-and-fetal-fibronectin-to-predict-preterm-birth
#7
COMPARATIVE STUDY
Reva Tripathi, Shakun Tyagi, Yedla M Mala, Nilanchali Singh, Nalini B Pandey, Preeti Yadav
OBJECTIVE: To compare the accuracy of rapid bedside tests for phosphorylated insulin-like growth factor-binding protein 1 (phIGFBP-1) and fetal fibronectin (fFN) to predict preterm delivery among women with threatened preterm labor. METHODS: A prospective observational study was conducted among women with a singleton pregnancy of 28-36 weeks, intact membranes, and symptoms suggestive of preterm labor who attended a center in New Delhi, India, between April 1, 2011, and March 31, 2014...
October 2016: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/27311172/-pheochromocytoma-and-pregnancy-a-case-report
#8
Ana Laura Merlos-Gutiérrez, Manuel Martínez-García, Andrés Pérez-Martínez, Sareni Chávez-Martínez, José Antonio Sereno-Coló
BACKGROUND: Pheochromocytoma is a tumor originating in the chromaffin cells. These tumors secrete catecholamines which act on target organs and cause hypertensive crises. They are rare during pregnancy, and a differential diagnosis must be carried out mainly with pregnancy-induced hypertension. CLINIC CASE: A 22-year-old patient in week 11.5 of pregnancy presented at the Hospital General Dr. Miguel Silva in Morelia, Michoacán with hypertension that had existed for more than two years with poor adherence to treatment...
November 2015: Ginecología y Obstetricia de México
https://www.readbyqxmd.com/read/27117951/variation-in-nicu-admission-rates-without-identifiable-cause
#9
Kathryn A Ziegler, David A Paul, Matthew Hoffman, Robert Locke
OBJECTIVES: Admission to the NICU is influenced by physiologic compromise and by hospital care protocols. Providing appropriate care must be balanced with adverse consequences of NICU admission, such as interrupting maternal-infant bonding and unnecessary interventions. This study aims to determine the variation in NICU admissions in term and late preterm infants among 19 hospitals. METHODS: We used the Consortium on Safe Labor (CSL) database to determine NICU admission rates...
May 2016: Hospital Pediatrics
https://www.readbyqxmd.com/read/26688491/maternal-plasma-angiogenic-index-1-placental-growth-factor-soluble%C3%A2-vascular-endothelial-growth-factor-receptor-1-is%C3%A2-a%C3%A2-biomarker-for-the-burden-of-placental-lesions-consistent-with%C3%A2-uteroplacental-underperfusion-a-longitudinal-case-cohort-study
#10
Steven J Korzeniewski, Roberto Romero, Tinnakorn Chaiworapongsa, Piya Chaemsaithong, Chong Jai Kim, Yeon Mee Kim, Jung-Sun Kim, Bo Hyun Yoon, Sonia S Hassan, Lami Yeo
BACKGROUND: Placental lesions consistent with maternal vascular underperfusion (MVU) are thought to be pathogenically linked to preeclampsia, small-for-gestational-age newborns, fetal death, and spontaneous preterm labor and delivery; yet, these lesions cannot be diagnosed antenatally. We previously reported that patients with such conditions and lesions have an abnormal profile of the angiogenic placental growth factor (PlGF) and antiangiogenic factors (eg, soluble vascular endothelial growth factor receptor [sVEGFR]-1)...
May 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/26510662/time-dependent-changes-in-insulin-requirement-for-maternal-glycemic-control-during-antenatal-corticosteroid-therapy-in-women-with-gestational-diabetes-a-retrospective-study
#11
Arata Itoh, Yoshifumi Saisho, Kei Miyakoshi, Marie Fukutake, Yoshifumi Kasuga, Daigo Ochiai, Tadashi Matsumoto, Mamoru Tanaka, Hiroshi Itoh
Though recommended for pregnant women at risk of preterm birth to improve perinatal outcomes, antenatal corticosteroid (ACS) treatment can cause maternal hyperglycemia, especially in cases of glucose intolerance. A standardized protocol for preventing hyperglycemia during ACS treatment remains to be established. We herein retrospectively investigated the time-dependent changes in insulin dose required for maternal glycemic control during ACS treatment in gestational diabetes (GDM). Twelve singleton pregnant women with GDM who received 12 mg of betamethasone intramuscularly twice 24 hours apart were included in this analysis...
2016: Endocrine Journal
https://www.readbyqxmd.com/read/26447057/routine-culture-based-screening-versus-risk-based-management-for-the-prevention-of-early-onset-group-b-streptococcus-disease-in-the-neonate-a-systematic-review
#12
REVIEW
Ella Kurz, Deborah Davis
BACKGROUND: Early-onset group B streptococcus disease, recognized as the most common cause of early onset neonatal sepsis in developed countries, is transmitted vertically from the group B streptococcus carrier mother to the neonate in the peripartum. Accordingly, early-onset group B streptococcus disease is prevented by halting the transmission of the microorganism from the mother to the infant. Two main methods, routine culture-based screening and risk-based management, may be used in the identification of mothers requiring intrapartum antibiotic prophylaxis in labor...
April 17, 2015: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/26412996/delayed-interval-delivery-in-dichorionic-twin-pregnancies-a-single-center-experience
#13
Mauro Cozzolino, Viola Seravalli, Giulia Masini, Lucia Pasquini, Mariarosaria Di Tommaso
BACKGROUND: Preterm delivery is the most common complication of multiple gestations and is associated with high perinatal mortality. When preterm labor occurs, delivery of the first fetus is inevitable. However, successfully delaying the delivery of the second fetus can be lifesaving. CASE REPORT: We report 2 cases of delayed-interval delivery of dichorionic diamniotic twin pregnancies admitted to our emergency department at 17+5 and 22+1 weeks of gestation. After abortion of the first fetus, the second twin was left in utero, and uterine contractions ceased...
2015: Ochsner Journal
https://www.readbyqxmd.com/read/26210791/basic-study-is-intravaginal-boric-acid-non-inferior-to-metronidazole-in-symptomatic-bacterial-vaginosis-study-protocol-for-a-randomized-controlled-trial
#14
RANDOMIZED CONTROLLED TRIAL
Melinda Zeron Mullins, Konia M Trouton
BACKGROUND: Bacterial vaginosis is associated with increased transmission of sexually transmitted infections, preterm labor, post-surgical infections, and endometritis. Current treatment for symptomatic bacterial vaginosis includes antibiotics, such as metronidazole, which are 70-80 % effective at one month after treatment and result in high recurrence rates and secondary candida infections. Intravaginal boric acid has been used for over a hundred years to treat vaginal infections, such as bacterial vaginosis...
July 26, 2015: Trials
https://www.readbyqxmd.com/read/25984349/the-icelandic-16-electrode-electrohysterogram-database
#15
Asgeir Alexandersson, Thora Steingrimsdottir, Jeremy Terrien, Catherine Marque, Brynjar Karlsson
External recordings of the electrohysterogram (EHG) can provide new knowledge on uterine electrical activity associated with contractions. Better understanding of the mechanisms underlying labor can contribute to preventing preterm birth which is the main cause of mortality and morbidity in newborns. Promising results using the EHG for labor prediction and other uses in obstetric care are the drivers of this work. This paper presents a database of 122 4-by-4 electrode EHG recordings performed on 45 pregnant women using a standardized recording protocol and a placement guide system...
2015: Scientific Data
https://www.readbyqxmd.com/read/25909122/-identification-the-risk-of-preterm-labor-the-role-of-fetal-fibronectin
#16
V Karamisheva, St Ivanov, A Nikolov, D Jordanova, G Dimitrov, A Nachev
UNLABELLED: Fibronectins represent a group of glycoproteins, which form "molecular glue" and are necessary in the interaction between a cell and a cell. The existence of fetal fibronectin in pregnant woman's vagina up to 22 g.w. is normal. In a normally proceeding pregnancy between 22 g.w. and 35 g.w. there is not supposed to be found fetal fibronectin in cervico-vaginal secretion. Its presence is a highly informative biological marker for the risk of premature birth. AIM: The aim of this research was to determine the risk for premature birth through applying fetal fibronectin test as a specific marker to pregnant women with or withthout symptoms of threatened birth...
2015: Akusherstvo i Ginekologii︠a︡
https://www.readbyqxmd.com/read/25826963/-histologic-chorioamnionitis-prevalence-in-patients-with-premature-rupture-membranes
#17
José Ignacio Garcia-de la Torre, Antonio Delgado-Rosas, Gerardo Gonzélez-Cantú
OBJECTIVE: Search Histologic Chorioamnionitis frequency in patients in week 28 (+/-) and pregnancy with premature rupture of membranes. PATIENTS AND METHOD: Retrospective and observational study in which we studied all patients who came between June 28, 2011 and November 15, 2011 to receive obstetric care in the service of Tocochirurgical of the University Hospital of Saltillo, with greater than or equal 28 weeks of pregnancy. RESULTS: 598 patients were studied, and the frequency of premature rupture of membranes with histologic chorioamnionitis at term patients was, respectively, 1...
December 2014: Ginecología y Obstetricia de México
https://www.readbyqxmd.com/read/25659469/17-alpha-hydroxyprogesterone-caproate-for-maintenance-tocolysis-a-systematic-review-and-metaanalysis-of-randomized-trials
#18
REVIEW
Gabriele Saccone, Anju Suhag, Vincenzo Berghella
We sought to evaluate the efficacy of maintenance tocolysis with 17-alpha-hydroxyprogesterone caproate (17P) compared to control (either placebo or no treatment) in singleton gestations with arrested preterm labor (PTL), in a metaanalysis of randomized trials. Electronic databases (MEDLINE, OVID, Scopus, ClinicalTrials.gov, and the Cochrane Central Register of Controlled Trials) were searched from 1966 through July 2014. Key words included "progesterone," "tocolysis," "preterm labor," and "17-alpha-hydroxyprogesterone caproate...
July 2015: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/25616327/synthesis-and-alkylation-of-aza-gly-pro-building-blocks-of-peptidomimetic-libraries-for-developing-prostaglandin-f2%C3%AE-receptor-modulators-as-therapeutics-to-inhibit-preterm-labor
#19
REVIEW
Carine B Bourguet, William D Lubell
Premature birth is a steadily increasing unmet medical need, for which new "tocolytic" agents are required to arrest contractions and delay labor. A peptide-based approach was developed to produce modulators of the prostaglandin F2α receptor as a novel target for tocolytic development. In this strategy, the solution-phase synthesis and alkylation of aza-glycyl-proline building blocks were key for the preparation of a series of modulators exhibiting biased signaling. An optimized method is now provided for making the aza-Gly-Pro unit with minimum side product, and alkylation of the unit is described to illustrate the library diversification step...
2015: Methods in Molecular Biology
https://www.readbyqxmd.com/read/25510036/-identification-of-preterm-labor-the-role-of-fetal-fibronectin-in-parents-with-symptoms
#20
V Karamisheva, S Ivanov, A Nikolov, D Jordanova, G Dimitrov, A Nachev
AIM: To determine whether the presence of fetal fibronectin in vaginal secretions of patients with symptoms suggestive of preterm labor predicts preterm delivery. Fetal fibronectin, a large molecular weight glycoprotein produced in the chorion, is expressed in cervical and vaginal secretions in women with disruption of the choriodecidual junction by labor or by inflammation. METHODS: A prospective observational longitudinal study from January 2013 till December 2013 was performed on patients between 24 and 32 weeks of gestation with symptoms of preterm labor, intact membranes, and cervical dilation < 4 cm (total patients = 86)...
2014: Akusherstvo i Ginekologii︠a︡
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