Sambhu M Pillai, Nicole H Sereda, Maria L Hoffman, Ellen V Valley, Thomas D Crenshaw, Young-Ki Park, Ji-Young Lee, Steven A Zinn, Kristen E Govoni
Poor maternal nutrition impairs overall growth and development of offspring. These changes can significantly impact the general health and production efficiency of offspring. Specifically, poor maternal nutrition is known to reduce growth of bone and muscle, and increase adipose tissue. Mesenchymal stem cells (MSC) are multipotent stem cells which contribute to development of these tissues and are responsive to changes in the maternal environment. The main objective was to evaluate the effects of poor maternal nutirtion during gestation on bone and MSC function in offspring...
2016: PloS One