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urinary system

Xiang-Long Qu, Bing Yan
By application of a straightforward postsynthetic modification strategy, a luminescent lanthanide-based MOFs hybrid material, Tb(III)@MOF-SO3 - , is first fabricated by loading Tb(III) ions into the pores of Zn-based MOF-SO3 - . This hybrid system is constructed on notable and specific luminous sensitization of MOF-SO3 - to Tb(III) ions. The further study shows that bi-metal-loaded Eu(III)/Tb(III)@MOF-SO3 - exhibits a Tb(III)-induced luminescence of Eu(III) ions, and the emissions of it all fall in the white region by altering the ratio of Eu(III)/Tb(III) ions and the excitation wavelengths...
June 18, 2018: Inorganic Chemistry
Victor D Plat, Nora van Gaal, James A Covington, Matthew Neal, Tim G J de Meij, Donald L van der Peet, Babs Zonderhuis, Geert Kazemier, Nanne K H de Boer, Freek Daams
BACKGROUND: Esophagectomy or pancreaticoduodenectomy is the standard surgical approach for patients with tumors of the esophagus or pancreatic head. Postoperative mortality is strongly correlated with the occurrence of anastomotic leakage (AL). Delay in diagnosis leads to delay in treatment, which ratifies the need for development of novel and accurate non-invasive diagnostic tests for detection of AL. Urinary volatile organic compounds (VOCs) reflect the metabolic status of an individual, which is associated with a systemic immunological response...
June 15, 2018: Digestive Surgery
Frank J Penedo, Michael H Antoni, Patricia I Moreno, Lara Traeger, Dolores Perdomo, Jason Dahn, Gregory E Miller, Steve Cole, Julian Orjuela, Edgar Pizarro, Betina Yanez
Almost 2.8 million men in the U.S. are living with prostate cancer (PC), accounting for 40% of all male cancer survivors. Men diagnosed with prostate cancer may experience chronic and debilitating treatment side effects, including sexual and urinary dysfunction, pain and fatigue. Side effects can be stressful and can also lead to poor psychosocial functioning. Prior trials reveal that group-based cognitive behavioral stress and self-management (CBSM) is effective in reducing stress and mitigating some of these symptoms, yet little is known about the effects of culturally-translated CBSM among Spanish-speaking men with PC...
June 14, 2018: Contemporary Clinical Trials
Sandra Peherstorfer, Hans Henning Brewitz, Ajay Abisheck Paul George, Amelie Wißbrock, Jana Maria Adam, Lutz Schmitt, Diana Imhof
BACKGROUND: Tight regulation of heme homeostasis is a critical mechanism in pathogenic bacteria since heme functions as iron source and prosthetic group, but is also toxic at elevated concentrations. Hemolysin-activating lysine-acyltransferase (HlyC) from Escherichia coli is crucial for maturation of hemolysin A, which lyses several mammalian cells including erythrocytes liberating large amounts of heme for bacterial uptake. A possible impact and functional consequences of the released heme on events employing bacterial HlyC have remained unexplored...
June 14, 2018: Biochimica et Biophysica Acta
Francisco Maciá Pérez, Leandro Zambrano Méndez, José Vicente Berná Martínez, Roberto Sepúlveda Lima
This article presents the design of a field programmable gate array (FPGA)-based prototype of a system on chip (SoC) capable of behaving as one of the nerve centres comprising the neuroregulatory system in humans: the cortical-diencephalic nerve centre. The neuroregulatory system is a complex nerve system consisting of a heterogeneous group of nerve centres. These centres are distributed throughout the length of the spinal cord, are autonomous, communicate via interneurons, and govern and regulate the behaviour of multiple organs and systems in the human body...
June 13, 2018: Computers in Biology and Medicine
H Aydogmus, U S Demirdal
OBJECTIVE: The association of vitamin D deficiency and pelvic floor dysfunction has been examined by numerous studies. Lower urinary tract symptoms (LUTS) associated with bladder filling and voiding functions are common in both sexes. A recent study reports a higher incidence of LTUS in men over 50 years old with vitamin D deficiency. The aim of the study is to investigate whether there is a difference in the Lower Urinary Tract Symptoms frequency between women with vitamin D deficiency and the control group or not...
June 9, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Kevin Duh, Michael G Funaro, William DeGouveia, Sonia Bahlani, Dominic Pappas, Souhel Najjar, Inna Tabansky, Robert Moldwin, Joel N H Stern
Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS) is a condition causing intense pelvic pain and urinary symptoms. While it is thought to affect millions of people and significantly impair quality of life, difficulty with diagnosis and a lack of reliably effective treatment options leave much progress to be made in managing this condition. We describe what is currently known about the immunological and neurological basis of this disease, focusing on the interactions between the immune and nervous system...
May 2018: Discovery Medicine
María Elena Alliende, José Antonio Arraztoa, Ulises Guajardo, Fernando Mellado
Objective: To describe and evaluate urinary hormone profiles in the luteal phase. Setting and Patients: Twenty-five healthy fertile women, with regular ovulatory pattern cycles as assessed by temperature and cervical mucus, at a university based center. Methods: Daily urinary hormonal assessment of luteinizing hormone, estrone glucuronide, and pregnanediol glucuronide. This was done during 3 or more cycles, with 78 completed cycles. Samples were analyzed by both crude levels and levels adjusted for the hormone excretion rate...
2018: Frontiers in Public Health
Sneha Patra, Pavla Bartošová-Sojková, Hana Pecková, Ivan Fiala, Edit Eszterbauer, Astrid S Holzer
BACKGROUND: Myxozoa are extremely diverse microscopic parasites belonging to the Cnidaria. Their life-cycles alternate between vertebrate and invertebrate hosts, predominantly in aquatic habitats. Members of the phylogenetically well-defined Sphaerospora (sensu stricto) clade predominantly infect the urinary system of marine and freshwater fishes and amphibians. Sphaerosporids are extraordinary due to their extremely long and unique insertions in the variable regions of their 18S and 28S rDNA genes and due to the formation of motile proliferative stages in the hosts' blood...
June 15, 2018: Parasites & Vectors
Hyunseung Nam, Seung Hun Jang, Yong Il Hwang, Joo-Hee Kim, Ji Young Park, Sunghoon Park
Background/Aims: The relationship between nonpulmonary organ failure and the development of acute respiratory distress syndrome (ARDS) in patients with sepsis has not been well studied. Methods: We retrospectively reviewed the medical records of patients with septic bacteremia admitted to the medical intensive care unit (ICU) of a tertiary academic hospital between January 2013 and December 2016. Results: The study enrolled 125 patients of median age 73...
June 14, 2018: Korean Journal of Internal Medicine
Erin Wolf, Edward J Diaz, Alison Hollis, Thien A Hoang, Hooman A Azad, Katharine M Bendt, Robert C Griffiths, Matthew A Sparks
Angiotensin (Ang) II is a major mediator of hypertension pathogenesis. In addition, there are well-documented differences in expression of the renin angiotensin system (RAS) components and Ang II responses between males and females, which may explain sex differences in blood pressure (BP) and hypertension epidemiology. We have previously shown that type 1A Angiotensin (AT1A) receptors in vascular smooth muscle cells (VSMCs) play a critical role in BP regulation and hypertension pathogenesis, but these studies were carried out in male mice...
June 13, 2018: American Journal of Physiology. Renal Physiology
Brett E Youngerman, Hojjat Salmasian, Eileen J Carter, Michael L Loftus, Rimma Perotte, Barbara G Ross, E Yoko Furuya, Robert A Green, David K Vawdrey
OBJECTIVE: To integrate electronic clinical decision support tools into clinical practice and to evaluate the impact on indwelling urinary catheter (IUC) use and catheter-associated urinary tract infections (CAUTIs).Design, Setting, and ParticipantsThis 4-phase observational study included all inpatients at a multicampus, academic medical center between 2011 and 2015.InterventionsPhase 1 comprised best practices training and standardization of electronic documentation. Phase 2 comprised real-time electronic tracking of IUC duration...
June 13, 2018: Infection Control and Hospital Epidemiology
Thomas Klockgether
Sporadic adult-onset ataxia (SAOA) is a nongenetic neurodegenerative disorder of the cerebellum of unknown cause which manifests with progressive ataxia. It is distinguished from hereditary ataxias and from acquired ataxias. SAOA also needs to be differentiated from multiple system atrophy of cerebellar type (MSA-C). Thus, the diagnosis of SAOA can only be made by exclusion. Although cerebellar ataxia is the prominent symptom in SAOA, patients often have additional nonataxia signs, including pyramidal tracts signs, decreased or absent ankle reflexes, sensory disturbances, mainly in the form of reduced vibration sense, and mild urinary symptoms that do not the fulfill the criteria for severe autonomic failure required for the diagnosis of MSA-C...
2018: Handbook of Clinical Neurology
Yi-Yu Peng, Hui-Tao Jing, Lan Luan, Ying-Ying Tu
OBJECTIVE: To observe the clinical efficacy of joint application of electroacupuncture (EA), acupointinjection and fire-needle in the treatment of menopausal syndrome (MS) women. METHODS: One hundred MS patients were randomized into control group and combined treatment group ( n =50 patients in each). The combined treatment group was treated by joint application of EA, acupoint-injection and fire-needle stimulation, and the control group treated by EA stimulation alone...
April 25, 2018: Zhen Ci Yan Jiu, Acupuncture Research
Philip A Catherwood, David Steele, Mike Little, Stephen Mccomb, James Mclaughlin
This paper presents an advanced Internet of Things point-of-care bio-fluid analyzer; a LoRa/Bluetooth-enabled electronic reader for biomedical strip-based diagnostics system for personalized monitoring. We undertake test simulations (technology trial without patient subjects) to demonstrate potential of long-range analysis, using a disposable test 'key' and companion Android app to form a diagnostic platform suitable for remote point-of-care screening for urinary tract infection (UTI). The 868 MHz LoRaWAN-enabled personalized monitor demonstrated sound potential with UTI test results being correctly diagnosed and transmitted to a remote secure cloud server in every case...
2018: IEEE Journal of Translational Engineering in Health and Medicine
Pietro Zuccarello, Gea Oliveri Conti, Federico Cavallaro, Chiara Copat, Antonio Cristaldi, Maria Fiore, Margherita Ferrante
Phthalates are endocrine-disrupting for their ability to change the normal function of human endocrine system. Their action on the reproductive system, both on male and female, is the most one investigated by international scientific community. The aim of this systematic review was to gather the available information regarding the role of phthalates on breast carcinogenesis focusing our research in their intake through the diet. Research was performed according the PRISMA methodology and 25 scientific articles published between 2000 and 2018 were selected...
June 7, 2018: Food and Chemical Toxicology
Nathaniel M Fried, Pierce B Irby
The flashlamp-pumped, solid-state holmium:yttrium-aluminium-garnet (YAG) laser has been the laser of choice for use in ureteroscopic lithotripsy for the past 20 years. However, although the holmium laser works well on all stone compositions and is cost-effective, this technology still has several fundamental limitations. Newer laser technologies, including the frequency-doubled, double-pulse YAG (FREDDY), erbium:YAG, femtosecond, and thulium fibre lasers, have all been explored as potential alternatives to the holmium:YAG laser for lithotripsy...
June 8, 2018: Nature Reviews. Urology
Elisa Sauer, Bruna Gauer, Sabrina Nascimento, Jessica Nardi, Gabriela Göethel, Bárbara Costa, Douglas Correia, Ursula Matte, Mariele Charão, Marcelo Arbo, Albert Duschl, Angela Moro, Solange Cristina Garcia
Benzene is a recognized human carcinogen; however, there are still some gaps in the knowledge regarding the mechanism of toxicity of this organic solvent and potential early biomarkers for the damage caused by it. In a previous study, our research group demonstrated that the adhesion molecules of the immune system (B7.1 and B7.2) could be potential biomarkers in the early detection of immunotoxicity caused by benzene exposure. Therefore, this study was developed to deepen the understanding regarding this important topic, aiming to contribute to the comprehension of the benzene toxicity mechanism mediated by B7...
June 5, 2018: Environmental Research
Steven T Truschel, Dennis R Clayton, Jonathan M Beckel, Jonathan G Yabes, Yi Yao, Amanda Wolf-Johnston, Lori A Birder, Gerard Apodaca
Lysosomal dysfunction is associated with a number of age-related pathologies that affect all organ systems. While much research has focused on neurodegenerative diseases and aging-induced changes in neurons, much less is known about the impact that aging has on lower urinary tract function. Our studies explored age-dependent changes in the content of endo-lysosomal organelles (i.e., multivesicular bodies, lysosomes, and the product of their fusion, endolysosomes) and age-induced effects on lysosomal degradation in the urothelium, the epithelial tissue that lines the inner surface of the bladder, ureters, and renal pelvis...
2018: PloS One
O Tiryaki, C Usalan, M Tarakcioglu, S Coban
BACKGROUND: Although nonhuman animal models have strongly suggested that vitamin D suppresses the renin-angiotensin system (RAS) and albuminuria, human data are largely lacking. The aim of this study was to examine the relationship between 25-hydroxyvitamin D [25-(OH)D] level and albuminuria and urinary angiotensinogen (UAGT) level in renal transplant recipients (RTRs). We also planned to investigate the effect of calcitriol treatment on albuminuria and UAGT level in these patients. METHODS AND RESULTS: A total of 124 nondiabetic RTRs participated in this study...
June 2018: Transplantation Proceedings
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