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https://www.readbyqxmd.com/read/29243096/miniaturisation-of-pcnl
#1
REVIEW
Sven Lahme
Conventional PCNL leads to a high stone-free rate but is associated with a significant treatment morbidity. To decrease the morbidity of PCNL but to achieve an equal stone-free rate, in 2001 a miniaturised version of a conventional PCNL (Mini-PCNL) was introduced. Meanwhile numerous modifications of the Mini-PCNL were reported. The ongoing experience with the Mini-PCNL technique showed that Mini-PCNL is not only a miniaturisation but also a different method to remove the stones, as the stones come out of the calyceal system only by means of the irrigation flow without any further need of forceps or baskets...
December 14, 2017: Urolithiasis
https://www.readbyqxmd.com/read/29241659/a-novel-method-for-predicting-kidney-stone-type-using-ensemble-learning
#2
Yassaman Kazemi, Seyed Abolghasem Mirroshandel
The high morbidity rate associated with kidney stone disease, which is a silent killer, is one of the main concerns in healthcare systems all over the world. Advanced data mining techniques such as classification can help in the early prediction of this disease and reduce its incidence and associated costs. The objective of the present study is to derive a model for the early detection of the type of kidney stone and the most influential parameters with the aim of providing a decision-support system. Information was collected from 936 patients with nephrolithiasis at the kidney center of the Razi Hospital in Rasht from 2012 through 2016...
December 11, 2017: Artificial Intelligence in Medicine
https://www.readbyqxmd.com/read/29240457/urinary-peptidomics-in-kidney-disease-and-drug-research
#3
Magdalena Krochmal, Joost P Schanstra, Harald Mischak
Due to its close connection with the renal system, urine is considered a valuable source of information in kidney disease research. Peptidomics methods focus on the discovery of endogenous peptides, given their wide range of biological functions and diagnostic and therapeutic potential. Representing a non-invasive and sensitive method, technological prospects of urinary peptidomics should be evaluated in the context of drug discovery and research. Areas covered: This review describes urinary peptidomics with focus on its application in drug research in the field of kidney diseases...
December 14, 2017: Expert Opinion on Drug Discovery
https://www.readbyqxmd.com/read/29240244/prenatal-diagnosis-of-urinary-tract-anomalies-a-cohort-study-in-the-northern-netherlands
#4
Marian K Bakker, Jorieke E H van Kammen, Hanneke Fleurke-Rozema, Esther Streefland, Valentina Gracchi, Caterina M Bilardo, Hermien E K De Walle
OBJECTIVE: To describe prevalence, time of diagnosis and type of birth in children and fetuses with urinary tract (UT) anomalies after the introduction of the anomaly scan in the Netherlands in 2007. METHODS: We selected, from a population-based congenital anomaly registry, children and fetuses with UT anomalies born between 2008-2014. Cases were defined according to type of UT anomaly and whether isolated or with associated anomalies. Information was collected on time of diagnosis and type of birth...
December 14, 2017: Prenatal Diagnosis
https://www.readbyqxmd.com/read/29238738/sociodemographic-characteristics-health-literacy-and-care-compliance-in-families-with-spina-bifida
#5
Jennifer Cooper, Deena Chisolm, Daryl J McLeod
Children with spina bifida experience varying rates of disease complications and health system overutilization. Data on sociodemographics, urinary tract infection, clean intermittent catheterization, and health system utilization were collected from caregiver-patient dyads. Newest Vital Sign (NVS) and Brief Health Literacy Screen (BRIEF) were administered to evaluate health literacy (HL). In total, 105 dyads completed enrolment with 24.8% versus 12.4% of caregivers scoring poor/marginal on the NVS and BRIEF, respectively...
2017: Global Pediatric Health
https://www.readbyqxmd.com/read/29238641/complication-rates-in-posterior-lumbar-interbody-fusion-plif-surgery-with-human-bone-morphogenetic-protein-2-medicare-population
#6
Raed Alobaidaan, Jeremiah R Cohen, Elizabeth L Lord, Zorica Buser, S Tim Yoon, Jim A Youssef, Jong-Beom Park, Darrel S Brodke, Jeffrey C Wang, Hans-Joerg Meisel
Study Design: Retrospective cohort study among Medicare beneficiaries who underwent posterior lumbar interbody fusion (PLIF) surgery. Objective: To identify the complication rates associated with the use of bone morphogenetic protein 2 (BMP2) in PLIF. Human BMP2 is commonly used in the "off-label" manner for various types of spine fusion procedures, including PLIF. However, recent studies have reported potential complications associated with the recombinant human BMP2 (rhBMP2) use in the posterior approach...
December 2017: Global Spine Journal
https://www.readbyqxmd.com/read/29237932/current-progress-and-controversies-in-prostate-cancer-management
#7
REVIEW
De-Xin Dong, Zhi-Gang Ji
OBJECTIVE: The optimal management strategy for prostate cancer (PCa) remains controversial. We performed a systemic review of current progress and controversies regarding the diagnosis and treatment of PCa. DATA SOURCES: We searched PubMed for recently published articles up to July 2017 using the following key words: "prostate cancer," "progress," "controversy," "immunotherapy," and "prevention." STUDY SELECTION: Articles were obtained and reviewed to provide a systematic review of the current progress and controversies regarding PCa management...
December 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/29237706/patient-characteristics-resource-use-and-outcomes-associated-with-general-internal-medicine-hospital-care-the-general-medicine-inpatient-initiative-gemini-retrospective-cohort-study
#8
Amol A Verma, Yishan Guo, Janice L Kwan, Lauren Lapointe-Shaw, Shail Rawal, Terence Tang, Adina Weinerman, Peter Cram, Irfan A Dhalla, Stephen W Hwang, Andreas Laupacis, Muhammad M Mamdani, Steven Shadowitz, Ross Upshur, Robert J Reid, Fahad Razak
BACKGROUND: The precise scope of hospital care delivered under general internal medicine services remains poorly quantified. The purpose of this study was to describe the demographic characteristics, medical conditions, health outcomes and resource use of patients admitted to general internal medicine at 7 hospital sites in the Greater Toronto Area. METHODS: This was a retrospective cohort study involving all patients who were admitted to or discharged from general internal medicine at the study sites between Apr...
December 11, 2017: CMAJ Open
https://www.readbyqxmd.com/read/29237379/male-urogen%C3%A4-tal-d%C3%A4-sorders-and-metabol%C3%A4-c-syndrome-poss%C3%A4-ble-l%C3%A4-nks-character%C3%A4-st%C3%A4-cs-and-potent%C3%A4-al-treatment-strateg%C3%A4-es
#9
Cetin Volkan Oztekin, Ecem Kaya, Didem Yilmaz-Oral, Serap Gur
BACKGROUND: Metabolic syndrome (MetS), as a cluster of metabolic derangements which is major risk factors for vascular disease, is one of the most important threats to public health. Although the epidemiological and limited amount of basic science and clinical evidence link MetS to several male urogenital disorders, a holistic approach aiming to define common mechanistic pathways and new possible therapeutic targets are lacking. OBJECTIVE: The current review has focused on providing scientific evidence on the role of MetS and its components on male urogenital disorders and the definition of new therapeutic targets...
December 12, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29234915/the-impact-of-exertional-heat-stress-on-gastrointestinal-integrity-gastrointestinal-symptoms-systemic-endotoxin-and-cytokine-profile
#10
Rhiannon M J Snipe, Anthony Khoo, Cecilia M Kitic, Peter R Gibson, Ricardo J S Costa
PURPOSE: The study aimed to determine the effects of exertional-heat stress on gastrointestinal integrity, symptoms, systemic endotoxin and inflammatory responses; and assess the relationship between changes in body temperature and gastrointestinal perturbations. METHODS: Ten endurance runners completed 2 h running at 60% [Formula: see text]O2max in hot (HOT: 35 °C) and temperate (TEMP: 22 °C)-ambient conditions. Rectal temperature (T re) and gastrointestinal symptoms were recorded every 10 min during exercise...
December 12, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/29234893/the-clinical-relevance-of-plasma-cd147-basigin-in-biopsy-proven-kidney-diseases
#11
Yoshiko Mori, Tomohiro Masuda, Tomoki Kosugi, Tomoki Yoshioka, Mayuko Hori, Hiroshi Nagaya, Kayaho Maeda, Yuka Sato, Hiroshi Kojima, Noritoshi Kato, Takuji Ishimoto, Takayuki Katsuno, Yukio Yuzawa, Kenji Kadomatsu, Shoichi Maruyama
BACKGROUND: Precise understanding of kidney disease activity is needed to design therapeutic strategies. CD147/basigin is involved in the pathogenesis of acute kidney injury and renal fibrosis through inflammatory cell infiltration. The present study examined the clinical relevance of CD147 in biopsy-proven kidney diseases that lead to the progression of chronic kidney disease. METHODS: Kidney biopsy specimens and plasma and urine samples were obtained from patients with kidney diseases, including IgA nephropathy (IgAN), Henoch-Schönlein purpura nephritis (HSPN), diabetic kidney disease (DKD), focal segmental glomerulosclerosis (FSGS), and membranous nephropathy (MN), who underwent renal biopsy between 2011 and 2014...
December 12, 2017: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/29234535/is-transurethral-incision-better-than-upper-pole-partial-nephrectomy-for-management-of-duplex-system-ureterocoele-diagnosed-in-the-first-year-of-life
#12
Amr Hodhod, Yasser A Noureldin, Mohamed El-Sherbiny
Objective: To compare the outcomes of transurethral incision (TUI) and upper pole partial nephrectomy (PN) in patients with duplex system ureterocoele (DSU). Patients and methods: We retrospectively reviewed the medical charts of patients who presented with DSU in the first-year of life and were managed with either TUI or PN. Patients' demographics, ultrasonography examinations, voiding cystourethrogram studies, and dimercaptosuccinic acid scans were reviewed. Also, the postoperative vesico-ureteric reflux status and febrile urinary tract infection occurrences, and subsequent surgical interventions were identified...
December 2017: Arab Journal of Urology
https://www.readbyqxmd.com/read/29234532/bilateral-same-session-ureterorenoscopy-a-feasible-approach-to-treat-pan-urinary-stone-disease
#13
Bora Özveren, Murat Tugrul Eren, Hakan Özveri, Uğur Altuğ, Ahmet Şahin
Objectives: To assess treatment effectiveness and safety of bilateral same-session ureterorenoscopy (BSSU) for the management of stone disease involving the entire urinary system. Patients and methods: We reviewed the records of 64 patients who underwent BSSU for the treatment of bilateral ureteric and/or kidney stones. Size, number, location per side, and the total burden of stones were recorded. Data on stenting, lithotripsy, and stone retrieval, and details of hospital stay and operation times were investigated...
December 2017: Arab Journal of Urology
https://www.readbyqxmd.com/read/29233628/xanthogranulomatous-pyelonephritis-in-a-paediatric-cohort-1963-2016-outcomes-from-a-large-single-center-series
#14
I Stoica, F O'Kelly, M B McDermott, F M J Quinn
BACKGROUND: Xanthogranulomatous pyelonephritis (XGP) is an uncommon chronic destructive granulomatous inflammation of the kidney. It was first described in 1916, and is thought to affect 6/1000 cases of pyelonephritis. Its manifestations are varied, and with a limited number of cases in the literature, the optimal diagnosis and management of XGP in the paediatric cohort is still unknown. MATERIAL AND METHODS: The medical records of children who were diagnosed and treated for XGP at the current unit during the period 1963-2016, inclusive, were retrospectively reviewed...
November 24, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29232268/pelvic-organ-prolapse-repair-using-the-uphold-vaginal-support-system-5-year-follow-up
#15
Päivi Rahkola-Soisalo, Tomi S Mikkola, Daniel Altman, Christian Falconer
OBJECTIVE: This study aimed to assess the long-term (5 years) outcomes of the Uphold Vaginal Support System for symptomatic vaginal apical prolapse with or without anterior colporraphy. METHODS: In total, 164 (81.2%) of 202 women operated on in 24 centers were reached for follow-up. Outcomes were assessed by using the Pelvic Organ Prolapse Quantification, the Pelvic Floor Distress Inventory 20, and the Pelvic Organ Prolapse/Urinary Incontinence Sexual Questionnaire questionnaires...
December 11, 2017: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/29231216/aronia-citrus-juice-polyphenol-rich-juice-intake-and-elite-triathlon-training-a-lipidomic-approach-using-representative-oxylipins-in-urine
#16
Libia Alejandra García-Flores, Sonia Medina, Cristina Gómez, Craig E Wheelock, Roberto Cejuela, José Miguel Martínez-Sanz, Camille Oger, Jean-Marie Galano, Thierry Durand, Álvaro Hernández-Sáez, Federico Ferreres, Ángel Gil-Izquierdo
In the present study, we examined whether particular urinary oxylipins (isoprostanes (IsoPs), leukotrienes (LTs), prostaglandins (PGs), and thromboxanes (TXs)) in 16 elite triathletes could alter during 145 days of training. Within this time span, 45 days were dedicated to examining the effects of the intake of a beverage rich in polyphenols (one serving: 200 mL per day) supplemented in their diet. The beverage was a mixture of citrus juice (95%) and Aronia melanocarpa juice (5%) (ACJ). Fifty-two oxylipins were analyzed in the urine...
December 12, 2017: Food & Function
https://www.readbyqxmd.com/read/29230653/environmental-exposure-to-cadmium-a-risk-for-health-of-the-general-population-in-industrialized-countries-and-preventive-strategies
#17
Magdalena Mezynska, Malgorzata M Brzóska
Cadmium (Cd) is a heavy metal belonging to the group of the main chemical pollutants of the natural and occupational environment in economically developed countries. The forecasts indicate that contamination of the environment with this toxic metal, and thus the exposure of the general population, will increase. Food (particularly plant products) is the main source of the general population exposure to this element. Moreover, an important, and often the main, source of intoxication with Cd is habitual tobacco smoking...
December 12, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29230385/urinary-microbiome-and-psychological-factors-in-women-with-overactive-bladder
#18
Peng Wu, Yang Chen, Jie Zhao, Guihao Zhang, Jiawei Chen, Junpeng Wang, Huijian Zhang
Objectives: Emerging evidence indicates that alterations to the urinary microbiome are related to lower urinary tract symptoms. Overactive bladder (OAB) is a common disorder with complex etiologies and usually accompanied by psychological diseases. More information concerning the urinary microbiome and psychological factors in OAB is required. The aim of this study was to characterize the female urinary microbiome associated with OAB and investigate the relationships between urinary microbiome and psychological factors...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29229730/role-of-ethanolamine-utilization-genes-in-host-colonization-during-urinary-tract-infection
#19
Anna Sintsova, Sara Smith, Sargurunathan Subashchandrabose, Harry L Mobley
Urinary tract infection (UTI) is the second most common infection in humans, making it a global health priority. Nearly half of all women will experience a symptomatic UTI, with uropathogenic E. coli (UPEC) being the major causative agent of the infection. While there has been extensive research on UPEC virulence determinants, the importance of host-specific metabolism remains understudied. Here we report that UPEC upregulate the expression of ethanolamine utilization genes during uncomplicated UTIs in humans...
December 11, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/29229221/intravesical-electromotive-botulinum-toxin-type-a-administration-for-management-of-urinary-incontinence-secondary-to-neuropathic-detrusor-overactivity-in-children-long-term-follow-up
#20
Seyedeh-Sanam Ladi-Seyedian, Lida Sharifi-Rad, Abdol-Mohammad Kajbafzadeh
OBJECTIVES: To investigate the long-term efficacy and success rate of intravesical electromotive botulinum toxin type A (BoNTA) "Dysport®" administration in myelomeningocele (MMC) patients who had urinary incontinence due to neuropathic detrusor overactivity (NDO). METHODS: Twenty four MMC patients (mean age: 9± 3.6 years, range: 3-16) were included in the study and followed up for six years. Using an electrode bladder catheter, 10 IU/kg of Dysport® (BoNTA) was inserted into the bladder for electromotive drug administration (EMDA) without anesthesia on outpatient basis...
December 8, 2017: Urology
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