keyword
MENU ▼
Read by QxMD icon Read
search

urinary system

keyword
https://www.readbyqxmd.com/read/29028400/label-free-study-of-cosmonaut-s-urinary-proteome-changes-after-long-duration-spaceflights
#1
A Brzhozovskiy, A Kononikhin, M Indeykina, LKh Pastushkova, I A Popov, E N Nikolaev, I M Larina
During the entire time that cosmonauts stay on board the international space station, different extreme space flight factors affect their bodies. In order to find out what physiological changes occur under the influence of spaceflight, different parameters of the human body before and after flights are monitored. Analysis of the urine proteome is one of the most perspective non-invasive methods of condition monitoring. The aim of the study was to perform a comparative semi-quantitative label-free urine proteome analysis of samples collected from 21 cosmonauts before and after long-duration spaceflight at the international space station...
August 2017: European Journal of Mass Spectrometry
https://www.readbyqxmd.com/read/29028163/early-detection-of-urinary-proteome-biomarkers-for-effective-early-treatment-of-pulmonary-fibrosis-in-a-rat-model
#2
Jianqiang Wu, Xundou Li, Mindi Zhao, He Huang, Wei Sun, Youhe Gao
PURPOSE: Pulmonary fibrosis (PF) is a progressive and devastating lung disease. With limited effective treatments available in the late stage, PF has a very poor prognosis. Molecular biomarkers are highly desired for PF, especially for its early phase. MATERIAL AND METHODS: Urine is a good biomarker source, and accumulates systemic changes in the body especially in the early-stage of diseases. In this study, a bleomycin (BLM)-induced rat model was used to mimic PF...
October 13, 2017: Proteomics. Clinical Applications
https://www.readbyqxmd.com/read/29027694/can-we-evaluate-hiatal-ballooning-by-measuring-the-anteroposterior-diameter-with-2-dimensional-translabial-ultrasonography
#3
Lieming Wen, Qichang Zhou
OBJECTIVES: To analyze the association between the anteroposterior hiatal diameter and pelvic organ prolapse and to determine whether 2-dimensional translabial ultrasonography can evaluate hiatal ballooning by measuring the anteroposterior diameter. METHODS: This study was a retrospective analysis of 312 women seen for lower urinary tract symptoms or pelvic organ prolapse between December 2014 and July 2016. All women had an International Continence Society (ICS) Pelvic Organ Prolapse Quantification (POP-Q) system examination and 4-dimensional translabial ultrasonography...
October 13, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/29024250/non-invasive-detection-of-bladder-cancer-via-expression-targeted-gene-delivery
#4
Yunlan Fang, B Wolfson, W T Godbey
BACKGROUND: Because of the time and expense associated with the procedures and possible distress to the patient, cystoscopy or other imaging techniques are typically not used for bladder cancer detection before symptoms become present. Alternatively, commercial assays for urinary tumor markers exist but are marred by low sensitivity and high cost. There is a need for a simple and sensitive means of tumor detection, such as via the analysis of urine. METHODS: Plasmids encoding the secretable reporter Gaussia luciferase (G...
October 11, 2017: Journal of Gene Medicine
https://www.readbyqxmd.com/read/29022114/implantable-systems-for-stress-urinary-incontinence
#5
REVIEW
Kenana M Al Adem, Sarah S Bawazir, Waleed A Hassen, Ahsan H Khandoker, Kinda Khalaf, Tim McGloughlin, Cesare Stefanini
Stress urinary incontinence (SUI), the involuntary urine leakage due to failure of the urethral closure mechanism, is a global health challenge with substantial human suffering and socioeconomic costs. Approximately 167 million male and female patients are predicted to suffer from SUI in 2018, worldwide. A wide range of surgical interventions are available for the treatment of SUI. Severe cases, however, usually require the implantation of artificial urinary sphincter devices. This review comparatively presents and analyzes the working principles, as well as the challenges, associated with the current implantable SUI systems in clinical use...
October 11, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/29021656/a-randomized-controlled-study-comparing-the-standard-tubeless-and-totally-tubeless-percutaneous-nephrolithotomy-procedures-for-renal-stones-from-a-tertiary-care-hospital
#6
Suresh Bhat, Jithin Lal, Fredrick Paul
INTRODUCTION: Percutaneous nephrolithotomy (PCNL) is an effective treatment for renal stones. Due to the significant pain and morbidity after standard PCNL because of nephrostomy tubes, various modifications of PCNL are being performed. We report a randomized trial comparing these modalities. MATERIALS AND METHODS: A total of 75 patients were randomized into three groups of 25 each: standard PCNL with nephrostomy tubes (Group 1), tubeless PCNL with ureteric stent and no nephrostomy (Group 2), and totally tubeless PCNL without ureteric catheter or nephrostomy (Group 3)...
October 2017: Indian Journal of Urology: IJU: Journal of the Urological Society of India
https://www.readbyqxmd.com/read/29021226/attenuation-of-accelerated-renal-cystogenesis-in-pkd1-mice-by-renin-angiotensin-system-blockade
#7
Wayne R Fitzgibbon, Yujing Dang, Marlene A Bunni, Catalin F Baicu, Michael R Zile, Adam E Mullick, Takamitsu Saigusa
BACKGROUND: The intrarenal renin angiotensin system (RAS) is activated in polycystic kidney disease. We have recently shown in the Pkd1 mouse that Gen 2 antisense oligonucleotide (ASO), which suppresses angiotensinogen (Agt) synthesis, is efficacious in slowing kidney cyst formation compared to lisinopril. The aim of this current study was to determine 1) if unilateral nephrectomy accelerates cystogenesis in Pkd1 mice (as previously shown in cilia knockout mice), and 2) whether Agt ASO can slow the progression in this accelerated cystic mouse model...
October 11, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29020797/extracellular-superoxide-dismutase-attenuates-renal-oxidative-stress-through-the-activation-of-ampk-in-diabetic-nephropathy
#8
Yu Ah Hong, Ji Hee Lim, Min Young Kim, Yaeni Kim, Hoon Suk Park, Hyung Wook Kim, Bum Soon Choi, Yoon Sik Chang, Hye Won Kim, Tae-Yoon Kim, Cheol Whee Park
AIMS: Oxidative stress plays a crucial role in the pathogenesis of diabetic nephropathy. We evaluated whether extracellular superoxide dismutase (EC-SOD) has a renoprotective effect through activation of AMPK in diabetic kidneys. RESULTS: Human recombinant EC-SOD (hEC-SOD) was administered to 8-week-old male C57BLKS/J db/db mice via subcutaneous injection once a week for 8 weeks. Renal SOD3 expression was suppressed in db/db mice, which was significantly enhanced by hEC-SOD treatment...
October 12, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/29019060/reports-of-three-cases-with-the-initial-presentation-of-mesenteric-vasculitis-in-children-with-system-lupus-erythematous
#9
REVIEW
Yuan Liu, Jia Zhu, Jian Ming Lai, Xue Feng Sun, Jun Hou, Zhi Xuan Zhou, Xin Yu Yuan
We reviewed three cases of systemic lupus erythematosus (SLE) in children with mesenteric vasculitis (LMV) as initial presentation and analysed their clinical characteristics to improve the understanding of this disease. Three patients with SLE were admitted to our hospital and initially presented with gastrointestinal symptoms. We retrospectively analysed their clinical data, including clinical presentations, laboratory results, images and short- and long-term treatment outcomes. (1) All three children were school-age girls...
October 10, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/29018604/effects-of-invasion-history-on-physiological-responses-to-immune-system-activation-in-invasive-australian-cane-toads
#10
Daniel Selechnik, Andrea J West, Gregory P Brown, Kerry V Fanson, BriAnne Addison, Lee A Rollins, Richard Shine
The cane toad (Rhinella marina) has undergone rapid evolution during its invasion of tropical Australia. Toads from invasion front populations (in Western Australia) have been reported to exhibit a stronger baseline phagocytic immune response than do conspecifics from range core populations (in Queensland). To explore this difference, we injected wild-caught toads from both areas with the experimental antigen lipopolysaccharide (LPS, to mimic bacterial infection) and measured whole-blood phagocytosis. Because the hypothalamic-pituitary-adrenal axis is stimulated by infection (and may influence immune responses), we measured glucocorticoid response through urinary corticosterone levels...
2017: PeerJ
https://www.readbyqxmd.com/read/29017737/laparoscopic-adenomectomy-10-years-of-experience
#11
J Carpio Villanueva, A Rosales Bordes, J Ponce de León Roca, M Montlleó González, J Caparrós Sariol, H Villavicencio Mavrich
INTRODUCTION: Lower urinary tract symptoms secondary to increased prostate volume are associated with ageing and are becoming more prevalent due to increased life expectancy. We present our experience with transperitoneal laparoscopic adenomectomy for the management of bladder outlet obstruction caused by benign prostatic enlargement. MATERIALS AND METHODS: We performed a retrospective review of patients who underwent laparoscopic adenomectomy between 2005 and 2015...
October 7, 2017: Actas Urologicas Españolas
https://www.readbyqxmd.com/read/29017568/polychlorinated-biphenyls-and-depression-cross-sectional-and-longitudinal-investigation-of-a-dopamine-related-neurochemical-path-in-the-german-helpcb-surveillance-program
#12
Petra Maria Gaum, Monika Gube, Thomas Schettgen, Franziska Maria Putschögl, Thomas Kraus, Bruno Fimm, Jessica Lang
BACKGROUND: Exposure to polychlorinated biphenyls (PCBs) is associated with depressive symptomatology. A cause of depressive symptoms is a disturbance in the neurotransmitter system of dopamine (DA). Animal as well as human studies report that PCBs can influence the DA system. This study examined whether PCB-related depressive symptoms are affected by DA metabolites in humans with high PCB body burden. METHODS: This study is part of the German HELPcB surveillance program (Health Effects in high Level exposure to PCB) for occupationally exposed workers and their relatives...
October 10, 2017: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/28994037/pathophysiology-diagnosis-and-treatment-of-inherited-distal-renal-tubular-acidosis
#13
REVIEW
Nilufar Mohebbi, Carsten A Wagner
Distal renal tubular acidosis (dRTA) is a tubular disorder with a primary defect of urinary acidification and acid excretion in the collecting duct system. Consequently, patients develop hyperchloremic metabolic acidosis with an inappropriately alkaline urine. Inherited forms of dRTA are due to mutations in at least three distinct genes: SLC4A1, ATP6V1B1, ATP6V0A4. Mutations in SLC4A1-(AE1) are inherited either in an autosomal dominant manner or in a recessive one. ATP6V1B and ATP6V0A4 mutations affect two different subunits of the vacuolar H(+)-ATPase proton-pump, the B1 and a4 subunits, and are inherited in an autosomal recessive manner...
October 9, 2017: Journal of Nephrology
https://www.readbyqxmd.com/read/28994022/evaluation-of-epigenetic-alterations-mir-126-and-mir-155-expression-levels-in-mexican-children-exposed-to-inorganic-arsenic-via-drinking-water
#14
Mónica S Pérez-Vázquez, Ángeles C Ochoa-Martínez, Tania RuÍz-Vera, Yesenia Araiza-Gamboa, Iván N Pérez-Maldonado
Recently, a great number of epidemiological studies have shown evidence that exposure to inorganic arsenic could have harmful effects on the cardiovascular system of humans. However, the underlying mechanisms through which arsenic induces cardiovascular toxic effects remain unclear. In this regard, epigenetic mechanisms have emerged as a probable connection between environment and disease phenotypes, including cardiovascular diseases. Therefore, this study aimed to evaluate epigenetic changes related to cardiotoxicity (miR-126 and miR-155 expression levels) in children from San Luis Potosi, Mexico exposed to inorganic arsenic...
October 6, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28993064/antimicrobial-susceptibility-of-microorganisms-that-cause-urinary-tract-infections-in-pediatric-patients
#15
Jesús Rodríguez-Lozano, Ana de Malet, María Eliecer Cano, Luis de la Rubia, Reinhard Wallmann, Luis Martínez-Martínez, Jorge Calvo
INTRODUCTION: Cumulative susceptibility reports are a valuable tool for the empirical treatment of urinary tract infections, especially in the current context of increasing resistance rates. Our objective was to analyze the antimicrobial susceptibility of bacterial isolates in urine cultures of pediatric patients during a five-year period. METHODS: Retrospective study of urine cultures from 2011 to 2015. Identification and antimicrobial susceptibility tests were performed using the Vitek-2 system (BioMérieux(®)) and categorized according to EUCAST criteria...
October 6, 2017: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/28992981/extended-spectrum-beta-lactamase-producing-escherichia-coli-and-klebsiella-pneumoniae-from-urinary-tract-infections-evolution-of-antimicrobial-resistance-and-treatment-options
#16
Gemma Jiménez-Guerra, Víctor Heras-Cañas, Lucía Del Carmen Béjar Molina, Antonio Sorlózano-Puerto, José María Navarro-Marí, José Gutiérrez-Fernández
BACKGROUND AND OBJECTIVES: A study of the susceptibility to antimicrobials of the extended spectrum beta-lactamase phenotypes (ESBL) in Escherichia coli and Klebsiella spp. was performed to discover the evolution of this type of resistance from urinary tract infections. MATERIAL AND METHOD: A retrospective study was carried out between 2012 and 2016. Susceptibility to ciprofloxacin, tobramycin, cefoxitin, fosfomycin, nitrofurantoin, co-trimoxazole, and carbapenems was analyzed using MicroScan(®) system...
October 7, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/28992950/future-horizons-in-allergy
#17
REVIEW
Michael J Marino, Amber U Luong
There are several advances in diagnosis and management for the otolaryngologist treating allergy. These include new technologies and the refinement of current techniques, and reflect overall trends in health care toward personalized medicine. Local immunoglobulin, urinary leukotriene E4, lipidomics, microRNA within extracellular vesicles, and optical rhinometry all offer to improve the diagnostic accuracy of allergy and related nonallergic conditions. New delivery systems for intranasal steroids and antihistamines, recombinant allergens, advances in allergen immunotherapy delivery, and biologics will improve current management options...
October 6, 2017: Otolaryngologic Clinics of North America
https://www.readbyqxmd.com/read/28992905/perioperative-occlusion-of-a-subcutaneous-ureteral-bypass-secondary-to-a-severe-pyonephrosis-in-a-birman-cat
#18
Bertrand Vedrine
A subcutaneous ureteral bypass (SUB) was placed in a 10-year-old Birman cat for management of unilateral ureterolithiasis. Perioperative occlusion of the nephrostomy tube of the SUB device happened secondary to a severe pyonephrosis. Flushing of the system throught the subcutaneous shunting port was made with saline solution after clamping the urinary bladder catheter. Repetitive flushing of the device was performed daily for 3 days to be sure of the remanent patency of the catheter. Repetitive flushing of the SUB device is a successful renal-sparing treatment for pyonephrosis in a cat and may be considered as an effective treatment option for this condition...
June 2017: Topics in Companion Animal Medicine
https://www.readbyqxmd.com/read/28992566/quantification-of-xanthine-and-uric-acid-related-compounds-in-urine-using-a-dilute-and-shoot-technique-coupling-ultra-high-performance-liquid-chromatography-and-high-resolution-orbitrap-mass-spectrometry
#19
Adrian Rodriguez, Rosa Maria Gomila, Gabriel Martorell, Antonia Costa-Bauza, Felix Grases
Quantitative analysis of relevant metabolites in biofluids such as urine is often a tedious procedure, since it usually requires extraction, purification or preconcentration. For instance, in the analysis of methylxanthines in urine, a solid-phase extraction is often required. In the current work, a rapid and highly sensitive "dilute-and-shoot" method combining ultra-high-performance liquid chromatography and high-resolution mass spectrometry (UHPLC/HRMS) was validated for urinary determination of twelve analytes: uric acid, hypoxanthine, xanthine, 1-methyluric acid, 1,3-dimethyluric acid, 1-methylxanthine, 3-methylxanthine, 7-methylxanthine, theophylline, theobromine, paraxanthine and caffeine...
October 2, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28990506/metabolomic-heterogeneity-of-urogenital-tract-cancers-analyzed-by-complementary-chromatographic-techniques-coupled-with-mass-spectrometry
#20
Arlette Yumba Mpanga, Wiktoria Struck-Lewicka, Renata Bujak, Marcin Markuszewski, Marek Roslan, Roman Kaliszan, Michał Jan Markuszewski
BACKGROUND: In regard to urogenital tract cancer studies, an estimated 340,650 new cases and 58,360 deaths from genital system cancer and about 141,140 new cases and 29330 deaths from urinary system were projected to occur in United States in 2012. The main drawbacks of currently available diagnostic tests constitute the low specificity, costliness and quite high invasiveness. OBJECTIVE: The main goal of this pilot study was to determine and compare urine metabolic fingerprints in urogenital tract cancer patients and healthy controls...
October 6, 2017: Current Medicinal Chemistry
keyword
keyword
84197
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"