Denise Mayumi Tanaka, Camila Godoy Fabricio, José A Marin-Neto, Antônio Carlos Leite de Barros Filho, Luciano Fonseca Lemos de Oliveira, Jorge Mejia, Rafael Ribeiro Almeida, Raquel de Souza Vieira, Carla Duque Lopes, Sabrina Setembre Batah, Henrique Turin Moreira, Maria de Lourdes Higuchi, Edecio Cunha Neto, Alexandre Todorovic Fabro, Stephan G Nekolla, Minna Moreira Dias Romano, Marcus Vinícius Simões
BACKGROUND: Myocardial perfusion defect (MPD) is common in chronic Chagas cardiomyopathy (CCC) and is associated with inflammation and development of left ventricular systolic dysfunction. We tested the hypothesis that pentoxifylline (PTX) could reduce inflammation and prevent the development of MPD in a model of CCC in hamsters. METHODS AND RESULTS: We investigated with echocardiogram and rest myocardial perfusion scintigraphy at baseline (6-months after T. cruzi infection/saline) and post-treatment (after additional 2-months of PTX/saline administration), female Syrian hamsters assigned to 3 groups: T...
December 2023: Journal of Nuclear Cardiology