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myocardial scintigraphy

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https://www.readbyqxmd.com/read/29777715/association-between-plasma-ceramides-and-inducible-myocardial-ischemia-in-patients-with-established-or-suspected-coronary-artery-disease-undergoing-myocardial-perfusion-scintigraphy
#1
Alessandro Mantovani, Stefano Bonapace, Gianluigi Lunardi, Matteo Salgarello, Clementina Dugo, Guido Canali, Christopher D Byrne, Stefania Gori, Enrico Barbieri, Giovanni Targher
BACKGROUND: Recent studies have suggested that specific plasma ceramides are independently associated with major adverse cardiovascular events in patients with coronary artery disease (CAD), but it is currently unknown whether plasma ceramide levels are associated with stress-induced reversible myocardial ischemia. METHODS: We measured six previously identified high-risk plasma ceramide molecules [Cer(d18:1/16:0), Cer(d18:1/18:0), Cer(d18:1/20:0), Cer(d18:1/22:0), Cer(d18:1/24:0), and Cer(d18:1/24:1)] in 167 consecutive patients with established or suspected CAD who underwent either exercise or dypiridamole myocardial perfusion scintigraphy (MPS) for various clinical indications...
May 16, 2018: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29750878/perfusion-scintigraphy-in-the-assessment-of-autologous-cell-therapy-in-diabetic-patients-with-critical-limb-ischemia
#2
A Nemcova, A Jirkovska, M Dubsky, R Bem, V Fejfarova, V Woskova, A Pysna, M Buncova
Perfusion scintigraphy with technetium-99-methoxy-isobutyl-isonitrile ((99m)Tc-MIBI) is often used for assessing myocardial function but the number of studies concerning lower limb perfusion is limited. The aim of our study was to assess whether (99m)Tc-MIBI was an eligible method for evaluation of the effect of cell therapy on critical limb ischemia (CLI) in diabetic patients. (99m)Tc-MIBI of calf muscles was performed before and 3 months after autologous cell therapy (ACT) in 24 diabetic patients with CLI...
May 10, 2018: Physiological Research
https://www.readbyqxmd.com/read/29720959/role-of-neuroimaging-as-a-biomarker-for-neurodegenerative-diseases
#3
REVIEW
Soichiro Shimizu, Daisuke Hirose, Hirokuni Hatanaka, Naoto Takenoshita, Yoshitsugu Kaneko, Yusuke Ogawa, Hirofumi Sakurai, Haruo Hanyu
It has recently been recognized that neurodegenerative diseases are caused by common cellular and molecular mechanisms including protein aggregation and inclusion body formation. Each type of neurodegenerative disease is characterized by the specific protein that aggregates. In these days, the pathway involved in protein aggregation has been elucidated. These are leading to approaches toward disease-modifying therapies. Neurodegenerative diseases are fundamentally diagnosed pathologically. Therefore, autopsy is essential for a definitive diagnosis of a neurodegenerative disease...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29717103/angina-pectoris-in-young-male-due-to-agenesis-of-left-circumflex-artery
#4
Thomas J Guterbaum, Kristian A Øvrehus, Karsten T Veien, Jacob E Møller, Hans Mickley
BACKGROUND This case study demonstrated that although highly symptomatic, agenesis of the left circumflex artery was a benign finding. Anomalies of the coronary arteries were found to be the cause of sudden death in a young individual. Left circumflex anomalies were not associated with major cardiac events. CASE REPORT A 20-year-old male was admitted due to syncope preceded by chest pain. His electrocardiogram (ECG) showed global ST segment elevation as well as biphasic T waves in anterior precordial leads...
May 2, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29709930/a-case-of-dilated-cardiomyopathy-with-eosinophilic-granulomatosis-with-polyangiitis-in-which-active-myocardial-inflammation-was-only-detected-by-endomyocardial-biopsy
#5
Takafumi Nakayama, Shunsuke Murai, Nobuyuki Ohte
Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare type of systemic vasculitis. Cardiac involvement is the main cause of death in patients with this disease. We herein report a case of congestive heart failure in a patient with EGPA. Neither 67 Ga scintigraphy nor cardiac magnetic resonance imaging detected inflammation of the myocardium; however, myocardial biopsy revealed numerous infiltrating inflammatory cells, thereby fulfilling the criteria of inflammatory dilated cardiomyopathy. We improved the LV systolic function by increasing the patient's prednisolone dosage...
April 27, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29706204/markers-of-reperfusion-and-long-term-8-year-prognosis-after-primary-percutaneous-coronary-intervention
#6
Gjin Ndrepepa, Robert A Byrne, Salvatore Cassese, Massimiliano Fusaro, Roisin Colleran, Julia Hieber, Karl-Ludwig Laugwitz, Heribert Schunkert, Adnan Kastrati
Thrombolysis in Myocardial Infarction (TIMI) flow, myocardial perfusion grade (MPG), and infarct size are established markers of reperfusion in patients with ST-segment elevation myocardial infarction. Whether these markers provide long-term prognostic information remains unknown. This study included 1,406 patients with ST-segment elevation myocardial infarction who underwent primary percutaneous coronary intervention. Postreperfusion TIMI flow, MPG, and infarct size (evaluated by scintigraphy at 7 to 14 days) were measured...
April 9, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29687207/diagnostic-accuracy-of-bone-scintigraphy-in-the-assessment-of-cardiac-transthyretin-related-amyloidosis-a-bivariate-meta-analysis
#7
Giorgio Treglia, Andor W J M Glaudemans, Francesco Bertagna, Bouke P C Hazenberg, Paola A Erba, Raffaele Giubbini, Luca Ceriani, John O Prior, Luca Giovanella, Riemer H J A Slart
PURPOSE: Cardiac transthyretin-related amyloidosis (ATTR) is a progressive and fatal cardiomyopathy. The diagnosis of this disease is frequently delayed or missed due to the limited specificity of echocardiography. An increasing amount of data in the literature demonstrate the ability of bone scintigraphy with bone-seeking radiopharmaceuticals to detect myocardial amyloid deposits, in particular in patients with ATTR. Therefore we performed a systematic review and bivariate meta-analysis of the diagnostic accuracy of bone scintigraphy in patients with suspected cardiac ATTR...
April 23, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29685202/correlation-between-immunological-inflammatory-markers-and-endothelial-disfunction-in-the-early-stage-of-coronary-heart-disease
#8
Viktor Persic, Ana Lanca Bastiancic, Ivan Rosovic, Damir Raljevic, Dijana Travica Samsa, Luka Bastiancic, Rajko Miskulin, Marko Boban, Gordana Laskarin
Classical risk factors for endothelial dysfunction (ED), such as age, gender, total cholesterol, high-density lipoprotein cholesterol, systolic blood pressure, and smoking history are utilised for the Framingham score and Systemic Coronary Risk Estimation (SCORE) for evaluation of the 10-year cardiovascular risk in routine practice. Nonetheless, pro-inflammatory mediators are deeply involved in the initiation and the progression of ED and coronary artery disease (CAD), and act additionally or independently of metabolic factors before clinical manifestations of the disease appear...
June 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29681962/myocardial-perfusion-scintigraphy-interpretation-of-gated-imaging-part-2
#9
REVIEW
Monika Z Czaja, Zbigniew Wygoda, Agata Duszańska, Dominik Szczerba, Jan Głowacki, Mariusz Gąsior, Jarosław P Wasilewski
The first part of the review describes the basic aspects of interpreting myocardial perfusion defects in single photon emission computed tomography (SPECT) scintigraphy. It also presents indications for invasive diagnostics based on stress perfusion defects. This article provides basic information concerning the interpretation of gated SPECT imaging, including such parameters as left ventricular wall motion and thickening as well as left ventricular wall systolic and diastolic function. Gated examination combined with the assessment of myocardial perfusion reduces the rate of false positives results of myocardial perfusion scintigraphy in perfusion tests, additionally providing data on left ventricular systolic and diastolic function...
March 2018: Kardiochirurgia i Torakochirurgia Polska, Polish Journal of Cardio-Thoracic Surgery
https://www.readbyqxmd.com/read/29673621/primary-thoracic-cancers-incidentally-detected-on-ct-attenuation-correction-images-during-myocardial-perfusion-scintigraphy
#10
Francis T Delaney, Kwun M Fong, Joseph C Lee
No abstract text is available yet for this article.
March 24, 2018: Clinical Lung Cancer
https://www.readbyqxmd.com/read/29649065/ageing-effect-on-18f-dopa-and-123i-mibg-uptake-a-cross-sectional-study
#11
Agostino Chiaravalloti, Gaetano Barbagallo, Maria Ricci, Pasqualina Sannino, Georgios Karalis, Francesco Ursini, Orazio Schillaci
BACKGROUND: The aim of this study was to investigate the relationship between age and uptake of fluorine-18-L-dihydroxyphenylalanine (F-DOPA) in the brain and myocardial uptake of iodine-123-metaiodobenzylguanidine (I-MIBG) in normal adult participants. PARTICIPANTS AND METHODS: To this end, a total of 72 healthy participants were enroled. Of these, 37 individuals (male, 21; female, 16; mean age: 60±12 years; age range: 38-85 years) underwent F-DOPA PET/CT, whereas 35 individuals (male, 19; female, 16; mean age: 61±17 years; age range: 17-87 years) underwent I-MIBG scintigraphy...
April 11, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29629998/predictive-and-prognostic-value-of-left-ventricular-mechanical-dyssynchrony-assessed-by-myocardial-perfusion-single-photon-emission-computed-tomography-in-asymptomatic-patients-under-hemodialysis
#12
Federico Caobelli, Cristina E Popescu, Riccardo Laudicella, Alessio Comis, Salvatore A Pignata, Roberto Sara, Claudio Rossetti
BACKGROUND: Patients under hemodialysis (HD) have an increased risk of major adverse cardiac events (MACEs). In these patients, myocardial perfusion scintigraphy (MPS) provides useful prognostic information. Left ventricular mechanical dyssynchrony (LVD) has been proven to predict all-cause death in patients under HD. It remains unclear, whether the same prognostic value pertains also to the prediction of MACEs. PATIENTS AND METHODS: Ninety patients under HD (duration range: 2-216 months) with neither history nor symptoms of coronary artery disease at the time of MPS were retrospectively evaluated...
May 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29602778/clinical-imaging-in-dementia-with-lewy-bodies
#13
REVIEW
Ajenthan Surendranathan, John Tiernan O'Brien
Dementia with Lewy bodies (DLB) is a common neurodegenerative dementia in older people; however, the clinical features, particularly cognitive fluctuations and rapid eye movement sleep disorder, are often hard to elicit, leading to difficulty in making the diagnosis clinically. Here we examine the literature for the evidence behind imaging modalities that could assist in making the diagnosis. Dopamine transporter (DAT) imaging remains the best modality for differentiation from dementia of Alzheimer's type with high sensitivity and specificity reported based on pathological diagnoses...
May 2018: Evidence-based Mental Health
https://www.readbyqxmd.com/read/29572255/cardiac-sympathetic-denervation-can-predict-the-wearing-off-phenomenon-in-patients-with-parkinson-s-disease
#14
Jee-Eun Lee, Joong-Seok Kim, Dong-Woo Ryu, Yoon-Sang Oh, Ie Ryung Yoo, Kwang-Soo Lee
Recent studies have suggested that preserved cardiac sympathetic denervation may be associated with a small motor burden in Parkinson's disease (PD), and serve as a "good" marker which is not associated with other non-motor symptoms. We sought to investigate whether cardiac sympathetic denervation increases the risk of the early wearing-off phenomenon in PD. Methods: This hospital-based prospective study enrolled 266 de novo patients with PD who underwent123 I-metaiodobenzylguanidine (MIBG) scintigraphy on initial evaluation...
March 23, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29561994/current-practices-in-myocardial-perfusion-scintigraphy-in-brazil-and-adherence-to-the-iaea-recommendations-results-of-a-cross-sectional-study
#15
Carlos Vitor Braga Rodrigues, Anderson Oliveira, Christiane Cigagna Wiefels, Maurício de Souza Leão, Cláudio Tinoco Mesquita
BACKGROUND: Data on the current situation of nuclear medicine practices in cardiology in Brazil are scarce. The International Atomic Energy Agency (IAEA) has recommended eight "good practices" to minimize patients' ionizing radiation exposure during myocardial perfusion scintigraphy (MPS). OBJECTIVES: To assess the adoption of the eight good practices in MPS in Brazil. METHODS: Cross-sectional study with data obtained by use of a questionnaire...
February 2018: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/29550324/native-t1-and-extracellular-volume-in-transthyretin-amyloidosis
#16
Ana Martinez-Naharro, Tushar Kotecha, Karl Norrington, Michele Boldrini, Tamer Rezk, Candida Quarta, Thomas A Treibel, Carol J Whelan, Daniel S Knight, Peter Kellman, Frederick L Ruberg, Julian D Gillmore, James C Moon, Philip N Hawkins, Marianna Fontana
OBJECTIVES: This study evaluated the prognostic potential of native myocardial T1 in cardiac transthyretin amyloidosis (ATTR) and compared native T1 with extracellular volume (ECV) in terms of diagnostic accuracy and prognosis. BACKGROUND: ATTR is an increasingly recognized cause of heart failure that has an overlapping clinical phenotype with hypertrophic cardiomyopathy (HCM). Native T1 mapping by cardiac magnetic resonance (CMR) is useful for diagnosis in cardiac amyloidosis but its prognostic potential has never been assessed...
March 12, 2018: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29546491/how-variable-are-the-volumetric-measurements-from-gated-perfusion-spect-when-a-one-day-stress-rest-protocol-is-used
#17
C Fielder Camm, Alexander Emery, Elizabeth Rose-Innes, Sergei Pavlitchouk, Nikant Sabharwal, Andrew D Kelion
BACKGROUND: Using myocardial perfusion scintigraphy (MPS), an increase in left ventricular (LV) volumes or a decrease in ejection fraction (EF) from rest to stress may be clinically important. The variation in these measures between the low-dose stress acquisition and high-dose rest acquisition in a one-day stress-rest protocol has not been established. We assessed the reproducibility of gated volumetric indices between stress and rest and the normal variation in ungated TID ratio for a one-day stress-rest 99m Tc-tetrofosmin protocol...
March 15, 2018: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/29511839/cardiac-denervation-evidenced-by-mibg-occurs-earlier-than-amyloid-deposits-detection-by-diphosphonate-scintigraphy-in-ttr-mutation-carriers
#18
Eve Piekarski, Renata Chequer, Vincent Algalarrondo, Ludivine Eliahou, Besma Mahida, Jonathan Vigne, David Adams, Michel S Slama, Dominique Le Guludec, Francois Rouzet
PURPOSE: Cardiac involvement in familial transthyretin (TTR) amyloidosis is of major prognostic value, and the development of early-diagnostic tools that could trigger the use of new disease-modifying treatments is crucial. The aim of our study was to compare the respective contributions of 99m Tc-diphosphonate scintigraphy (DPD, detecting amyloid deposits) and 123 I-MIBG (MIBG, assessing cardiac sympathetic denervation) in patients with genetically proven TTR mutation referred for the assessment of cardiac involvement...
July 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29476454/isolated-cardiac-amyloidosis-utility-of-bone-seeking-tracers-scintigraphy-in-differentiating-the-subtype-of-amyloid-a-case-report
#19
O Bourogianni, E Papadaki, E Foukarakis, S Koukouraki
BACKGROUND: Three types of amyloid are responsible for cardiac amyloidosis. Differentiation of the subtype is critical for the disease progression and the therapeutic decision. RESULTS: Myocardial scintigraphy using Tc-PYP is able to differentiate the cardiac amyloid subtype with high sensitivity and specificity. The myocardial uptake of PYP is higher in patients with TTR amyloidosis. CONCLUSION: Non-invasive tests for the detection of cardiac amyloidosis, like myocardial scintigraphy with bone seeking tracers, can play a major role in the diagnosis progression and therapeutic management of patients with cardiac amyloidosis...
February 23, 2018: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/29475590/validation-of-iodine-131-meta-iodobenzylguanidine-cardiac-scintigraphy-in-parkinsonism-a-preliminary-study
#20
Dan Xu, Wenjia Zhu, Li Huo, Shikun Zhu, Fang Li, Han Wang
INTRODUCTION: 123 I-MIBG is the most commonly used radiopharmaceutical to depict cardiac sympathetic innervation. The purpose of this study was to validate the feasibility of 131 I-MIBG as an alternative myocardial sympathetic imaging probe in differential diagnosis of Parkinsonism. METHODS: We recruited 17 patients with PD, 21 patients with other parkinsonism (17 with MSA and 4 with PSP), and 6 normal controls. All participants underwent 131 I-MIBG scintigraphy for both early and delayed imaging...
May 2018: Parkinsonism & related Disorders
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