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Cancer oropharynx

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https://www.readbyqxmd.com/read/29788169/hpv-status-like-politics-is-local-evaluating-p16-staining-and-a-new-staging-system-in-a-dutch-cohort-of-oropharynx-cancer
#1
R K Orosco, J A Califano
No abstract text is available yet for this article.
May 1, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29787349/head-and-neck-cancer-patients-rates-reasons-and-risk-factors-for-30-day-unplanned-readmission
#2
Michael K Ghiam, Alexander Langerman, Zoukaa Sargi, Sarah Rohde
Objective To analyze rates, risk factors, and complications for 30-day readmission among head and neck cancer (HNC) patients. Methods Retrospective review of administrative records from Vizient (Irving, Texas) Clinical Data Base/Resource Manager on HNC patients who underwent a head and neck surgical procedure from January 2013 through September 2015 at 176 academic and community medical centers. Results Of the 18,121 patients included in the study, 2502 patients were readmitted within 30 days (13.8%). Mean time to readmission was 11 ± 8...
May 1, 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29770611/the-changing-aetiology-of-head-and-neck-squamous-cell-cancer-a-tale-of-three-cancers
#3
Steven J Thomas, Chris M Penfold, Andrea Waylen, Andrew R Ness
Head and neck cancers are the sixth most common cancers worldwide and an important cause of ill health.(1) Each year about 9000 cases are reported in the UK.(2) Survival is poor and despite advances in treatment, has not improved until recently.(3) The majority of head and neck cancers are squamous cell carcinomas, affecting the larynx, oropharynx and oral cavity. The aetiology is changing and this has implications for prevention and treatment. Twenty years ago, tobacco and alcohol consumption were considered to be the established risk factors and it was estimated that these risk factors accounted for about 75% of cases...
May 16, 2018: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29731889/swallowing-disorder-following-salvage-total-pharyngo-laryngo-esophagectomy-with-free-jejunum-reconstruction
#4
Takashi Maruo, Minoru Sakuraba, Takeshi Shinozaki, Toshifumi Tomioka, Wataru Okano, Satoko Arahira, Yoshie Iino, Ryuichi Hayashi
For recurrent cases or residual cases following concomitant chemo-radiation therapy (CCRT), salvage surgery is a frequently used treatment options. A swallowing disorder is one of the major complications of CCRT. The purpose of the present study was to evaluate the effect of CCRT on swallowing function in patients who underwent salvage total pharyngo-laryngo-esophagectomy (TPLE), and to evaluate the importance of pharyngeal constriction in patients who underwent TPLE. Between 2008 January and 2014 May, 54 patients were treated with salvage TPLE following CCRT or TPLE at the National Cancer Center Hospital East, Chiba, Japan and were included in the present study...
May 2018: Oncology Letters
https://www.readbyqxmd.com/read/29731552/oral-cancer-statistics-in-india-on-the-basis-of-first-report-of-29-population-based-cancer-registries
#5
Swati Sharma, L Satyanarayana, Smitha Asthana, K K Shivalingesh, Bala Subramanya Goutham, Sujatha Ramachandra
Objectives: To summarize and provide an overview of age-specific oral cancer incidence reported in 29 population-based cancer registry in India. Materials and Methods: Secondary data on age-adjusted rates (AARs) of incidence of oral cancer and other associated sites for all ages (0-75 years) were collected from the report of the National Cancer Registry Programme 2012-2014 in 29 population-based control registries. Results: Among both males and females, mouth cancer had maximum Age adjusted incidence rates (64...
January 2018: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/29727312/routine-adaptive-replanning-of-p16-positive-stage-n2b-oropharyngeal-cancer-quality-improvement-or-waste-of-time
#6
James H Zhu, Robert J Amdur, Bo Lu, Chihray Liu, Kathryn E Hitchcock, William M Mendenhall
PURPOSE/OBJECTIVE(S): To determine if routinely replanning patients treated for oropharyngeal cancer that is p16-positive and clinical neck stage N2b (AJCC 7th edition) is likely to result in dose changes that will improve patient outcomes to a meaningful degree. METHODS: In 10 consecutive patients treated with primary radiotherapy (RT) and concurrent weekly chemotherapy for p16-positive N2b oropharyngeal carcinoma, we prospectively evaluated dose changes from replanning for the final 4 or 2 weeks of RT of a 7-week RT program...
May 4, 2018: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29722676/erratum-to-routman-dm-funk-rk-tangsriwong-k-et-al-relapse-rates-with-surgery-alone-in-human-papillomavirus-related-intermediate-and-high-risk-group-oropharynx-squamous-cell-cancer-a-multi-institutional-review-int-j-radiat-oncol-biol-phys-2017-99-938-946
#7
https://www.readbyqxmd.com/read/29713583/identification-of-malignancy-associated-changes-in-histologically-normal-tumor-adjacent-epithelium-of-patients-with-hpv-positive-oropharyngeal-cancer
#8
James Jabalee, Anita Carraro, Tony Ng, Eitan Prisman, Cathie Garnis, Martial Guillaud
The incidence of HPV-positive oropharyngeal cancer (HPV+ OPC) is increasing, thus presenting new challenges for disease detection and management. Noninvasive methods involving brush biopsies of diseased tissues were recently reported as insufficient for tumor detection in HPV+ OPC patients, likely due to differences between the site of tumor initiation at the base of involuted crypts and the site of brush biopsy at the crypt surface. We hypothesized that histologically normal surface epithelial cells in the oropharynx contain changes in nuclear morphology that arise due to tumor proximity...
2018: Analytical Cellular Pathology (Amsterdam)
https://www.readbyqxmd.com/read/29710383/a-snapshot-of-the-evolving-epidemiology-of-oropharynx-cancers
#9
EDITORIAL
Anil K Chaturvedi, Zachary S Zumsteg
No abstract text is available yet for this article.
April 30, 2018: Cancer
https://www.readbyqxmd.com/read/29710108/association-of-a-proactive-swallowing-rehabilitation-program-with-feeding-tube-placement-in-patients-treated-for-pharyngeal-cancer
#10
Gaurav S Ajmani, Cheryl C Nocon, Bruce E Brockstein, Nicholas P Campbell, Amy B Kelly, Jamie Allison, Mihir K Bhayani
Importance: A proactive speech and language pathology (SLP) program is an important component of the multidisciplinary care of patients with head and neck squamous cell carcinoma (HNSCC). Swallowing rehabilitation can reduce the rate of feeding tube placement, thereby significantly improving quality of life. Objective: To evaluate the initiation of a proactive SLP rehabilitation program at a single institution and its association with rates of feeding tube placement and dietary intake in patients with HNSCC...
April 19, 2018: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29708483/sexual-behaviour-hpv-status-and-p16-ink4a-expression-in-oropharyngeal-and-oral-cavity-squamous-cell-carcinomas-a-case-case-comparison-study
#11
Sarah Emmett, Samuel Boros, David C Whiteman, Sandro V Porceddu, Benedict J Panizza, Annika Antonsson
A significant proportion of mucosal squamous cell carcinomas of the head and neck (HNSCC; particularly of the oropharynx) are directly attributable to the human papillomavirus (HPV). The increase in the incidence of HPV-related tumours has been postulated to be due to changing sexual practices in the community. We analysed 136 formalin-fixed paraffin-embedded squamous cell carcinomas from the oral cavity (n=40) and oropharynx (n=96) recruited from the Princess Alexandra Hospital (Brisbane, Australia). Samples were analysed for the presence of HPV DNA using a combination of mucosal HPV general primer GP+ PCR and sequencing; p16INK4a expression was assessed by immunohistochemistry...
April 30, 2018: Journal of General Virology
https://www.readbyqxmd.com/read/29694489/speech-language-therapy-program-for-mouth-opening-in-patients-with-oral-and-oropharyngeal-cancer-undergoing-adjuvant-radiotherapy-a-pilot-study
#12
Caroline Somera Marrafon, Leandro Luongo Matos, Marcia Simões-Zenari, Claudio Roberto Cernea, Katia Nemr
Purpose Assess the effectiveness of an orofacial myofunctional therapeutic program in patients with oral or oropharyngeal cancer submitted to adjuvant radiotherapy through pre- and post-program comparison of maximum mandibular opening. Methods Prospective study involving five adult patients and five elderly patients postoperatively to oral cavity/oropharynx surgery who were awaiting the beginning of radiotherapy or had undergone fewer than five treatment sessions. The study participants had their maximum jaw opening measured using a sliding caliper at the beginning and end of the program...
2018: CoDAS
https://www.readbyqxmd.com/read/29690934/multi-dimensional-analysis-of-oral-cavity-and-oropharyngeal-defects-following-cancer-extirpation-surgery-a-cadaveric-study
#13
Sherif Idris, Alex M Mlynarek, Khalid Ansari, Jeffrey R Harris, Nabil Rizk, David Cote, Daniel A O'Connell, Heather Allen, Peter Dziegielewski, Hadi Seikaly
BACKGROUND: Defects following resection of tumors in the head and neck region are complex; more detailed and defect-specific reconstruction would likely result in better functional and cosmetic outcomes. The objectives of our study were: 1) to improve the understanding of the two- and three-dimensional nature of oral cavity and oropharyngeal defects following oncological resection and 2) to assess the geometric dimensions and the shapes of fasciocutaneous free flaps and locoregional tissue flaps required for reconstruction of these defects...
April 24, 2018: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29682090/the-neuropeptide-genes-sst-tac1-hcrt-npy-and-gal-are-powerful-epigenetic-biomarkers-in-head-and-neck-cancer-a-site-specific-analysis
#14
Kiyoshi Misawa, Masato Mima, Atsushi Imai, Daiki Mochizuki, Yuki Misawa, Shiori Endo, Ryuji Ishikawa, Takeharu Kanazawa, Hiroyuki Mineta
Background: Staging and pathological grading systems are convenient but imperfect predictors of recurrence in head and neck squamous cell carcinoma (HNSCC). Identifying biomarkers for HNSCC that will progress and cause death is a critical research area, particularly if the biomarker can be linked to selection of patients. Therefore, to identify potential alternative prognostic markers, we investigated the methylation status of five neuropeptide gene promoters. The promoter methylation status was determined by quantitative methylation-specific PCR in 230 cases of HNSCC; 58 hypopharynx, 45 larynx, 56 oropharynx, and 71 oral cavity tumor samples were studied...
2018: Clinical Epigenetics
https://www.readbyqxmd.com/read/29680854/impact-of-the-anatomical-location-alcoholism-and-smoking-on-the-prevalence-of-advanced-oral-cancer-in-brazil
#15
N-V-F Bezerra, K-L-F Leite, M-M-D de Medeiros, M-L Martins, A-M-R Cardoso, P-M Alves, W-W-N Padilha, Y-W Cavalcanti
BACKGROUND: To evaluate the prevalence of oral cancer in Brazil according to the clinical stage, anatomical location, alcoholism and smoking. MATERIAL AND METHODS: Data referring to 31,217 cases of oral cancer, from 2000 to 2010, were obtained from the Integrator Module of the Hospital Registry of Cancer. Inconsistent data (non-classified cases) was eliminated and 21,160 cases were analyzed. The frequency distribution according to clinical stage, anatomical location, alcoholism and smoking was analyzed descriptively and through a binary logistic regression model (α<0...
April 22, 2018: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/29679492/knowledge-based-automated-planning-for-oropharyngeal-cancer
#16
Aaron Babier, Justin J Boutilier, Andrea L McNiven, Timothy C Y Chan
PURPOSE: To automatically generate radiation therapy plans for oropharynx patients by com-bining knowledge-based planning (KBP) predictions with an inverse optimization (IO) pipeline. METHODS: We developed two KBP approaches, the bagging query (BQ) method and the generalized principal component analysis-based (gPCA) method, to predict achievable dose volume histograms (DVHs). These approaches generalize existing methods by predicting physically feasible organ-at-risk (OAR) and target DVHs in sites with multiple targets...
April 21, 2018: Medical Physics
https://www.readbyqxmd.com/read/29673737/epidemiological-features-of-cancers-of-the-oral-cavity-oropharynx-hypopharynx-and-larynx-cancer-in-r%C3%A3-union-island
#17
A Delagranda, G Leterme, E Chirpaz, C Ferdynus, C Fernandez, F Rubin
INTRODUCTION: This study had two objectives: firstly, to identify and compare characteristics of cancer of the oral cavity, oropharynx, hypopharynx and larynx in Réunion Island, a tropical French overseas territory in the southern hemisphere; and secondly, to discuss how incidence of these cancers is presented in the international literature. MATERIAL AND METHOD: A retrospective study included 599 patients diagnosed with cancer of the oral cavity, oropharynx, hypopharynx or larynx between 2009 and 2013 in Réunion Island...
April 16, 2018: European Annals of Otorhinolaryngology, Head and Neck Diseases
https://www.readbyqxmd.com/read/29670856/cdkn2a-copy-number-loss-is-an-independent-prognostic-factor-in-hpv-negative-head-and-neck-squamous-cell-carcinoma
#18
William S Chen, Ranjit S Bindra, Allen Mo, Thomas Hayman, Zain Husain, Joseph N Contessa, Stephen G Gaffney, Jeffrey P Townsend, James B Yu
Background: HPV infection is associated with high p16 expression and good prognosis in head and neck squamous cell carcinomas (HNSCCs). Analysis of CDKN2A, the gene encoding p16, may further elucidate the association between p16 expression and prognosis. We sought to determine whether CDKN2A copy number loss was associated with poor survival in HPV-negative HNSCCs. Methods: The Cancer Genome Atlas HNSCC clinical and genomic data were obtained and integrated. Patients <80 years old with a primary tumor in the oral cavity, oropharynx, hypopharynx, or larynx were included...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29629890/infective-complications-after-free-flaps-reconstruction-in-patients-affected-by-head-and-neck-cancer-our-experience-on-77-cases
#19
Giovanni Dell'Aversana Orabona, Raffaele Corvino, Fabio Maglitto, Vincenzo Abbate, Paola Bonavolontà, Antonio Romano, Giovanni Salzano, Luigi Califano
AIM: The success rates of free flaps in patients undergoing head and neck cancer (HNC) surgery are very high (95%- 97%) but the development of a surgical site infection (SSI) can put flap viability at risk. The aim of our study is to identify the risk factors for SSI in patients undergo free flaps reconstruction after head and neck cancer removal. MATERIAL OF STUDY: Seventyseven patients (44 male and 33 female) from April 2006 to April 2015 admitted at the Department of Maxillofacial Surgery of the University of Naples "Federico II" were included in this study...
2018: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/29628167/clinicopathological-features-of-squamous-cell-carcinoma-of-the-oral-cavity-and-oropharynx-in-young-patients
#20
R C-P Martinez, H P Sathasivam, B Cosway, V Paleri, S Fellows, J Adams, M Kennedy, R Pearson, A Long, P Sloan, M Robinson
Our aim was to examine the clinicopathological features of squamous cell carcinoma (SCC) of the oral cavity and oropharynx in a group of young patients who were dignosed during a 15-year period (2000-2014). Patients' clinical details, risk factors, and survival were obtained from medical records. Formalin-fixed, paraffin-embedded, tissue was tested for high-risk human papillomavirus (HPV). The results were compared with those of a matching group of older patients. We identified 91 patients who were younger than 45 years old, and the 50 youngest patients were studied in detail...
April 5, 2018: British Journal of Oral & Maxillofacial Surgery
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