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Cancer oropharynx

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https://www.readbyqxmd.com/read/28511960/inadequate-target-volume-delineation-and-local-regional-recurrence-after-intensity-modulated-radiotherapy-for-human-papillomavirus-positive-oropharynx-cancer
#1
Allen M Chen, Robert Chin, Philip Beron, Taeko Yoshizaki, Argin G Mikaeilian, Minsong Cao
PURPOSE: To perform a spatial analysis of local-regional recurrences, in relation to quantitative dose distribution, among patients treated by intensity-modulated radiotherapy (IMRT) for human papillomavirus (HPV)-positive oropharyngeal cancer. METHODS AND MATERIALS: The records of 107 consecutive patients who presented for consideration of re-irradiation for local-regional recurrent disease occurring in a previously irradiated field were reviewed. The original IMRT plans were retrieved for those with HPV-positive disease originating from the oropharynx, and deformable image registration was used to fuse the magnetic resonance imaging (MRI) and positron emission tomography (PET) scans obtained at recurrence to the pre-treatment planning computed tomography (CT) dataset...
May 13, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28496456/swallowing-disorders-after-oral-cavity-and-pharyngolaryngeal-surgery-and-role-of-imaging
#2
REVIEW
Caterina Giannitto, Lorenzo Preda, Valeria Zurlo, Luigi Funicelli, Mohssen Ansarin, Salvatore Di Pietro, Massimo Bellomi
Head and neck squamous cell carcinoma is the sixth most common cancer diagnosed worldwide and the eighth most common cause of cancer death. Malignant tumors of the oral cavity, oropharynx, and larynx can be treated by surgical resection or radiotheraphy with or without chemotheraphy and have a profound impact on quality of life functions, including swallowing. When surgery is the chosen treatment modality, the patient may experience swallowing impairment in the oral and pharyngeal phases of deglutition. A videofluoroscopic study of swallow enables the morphodynamics of the pharyngeal-esophageal tract to be accurately examined in patients with prior surgery...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28490940/systemic-therapy-in-the-curative-treatment-of-head-and-neck-squamous-cell-cancer-cancer-care-ontario-clinical-practice-guideline
#3
E Winquist, C Agbassi, B M Meyers, J Yoo, K K W Chan
OBJECTIVE: The aim of the present work was to make recommendations about the use of systemically administered drugs in combination or in sequence with radiation (rt) or surgery, or both, for cure or organ preservation, or both, in patients with locally advanced nonmetastatic (stages iii-ivb) squamous cell carcinoma of the head and neck (lascchn). METHODS: The Meta-analysis of Chemotherapy in Head and Neck Cancer (mach-nc) reports have, de facto, guided practice since 2000, and so we searched the literature for systematic reviews published from January 2000 to February 2015 in reference to five research questions...
April 2017: Current Oncology
https://www.readbyqxmd.com/read/28485297/analysis-of-risk-factors-for-oral-cavity-and-oropharynx-cancer-in-the-authors-own-material
#4
Joanna Nowosielska-Grygiel, Kalina Owczarek, Marzena Bielińska, Magdalena Wacławek, Jurek Olszewski
INTRODUCTION: The aim of the study was to analyse the risk factors for oral cavity and oropharynx cancer in peopled examined under the Head and Neck Cancer Awareness Week in 2016, Lodz. MATERIAL AND METHODS: In Lodz, 21st September 2016, under the Head and Neck Cancer Awareness Week, 106 people, including 67 women aged 29-77 and 39 men aged 23-84, underwent preventive examinations in the hospital department. Prior to the laryngological examination, the patients were asked to answer questions that referred to their education, medical case history, symptoms, smoking habits with the number of cigarettes per day, alcohol intake, the number of lifetime sexual partners, oral sex engagement, incidents of head and neck cancer in the family history...
April 30, 2017: Otolaryngologia Polska
https://www.readbyqxmd.com/read/28483336/prospective-study-of-cetuximab-carboplatin-and-radiation-therapy-for-patients-with-locally-advanced-head-and-neck-squamous-cell-cancer-unfit-for-cisplatin
#5
June Corry, Mathias Bressel, Tsien Fua, Alan Herschtal, Benjamin Solomon, Sandro V Porceddu, Chris Wratten, Danny Rischin
PURPOSE: To report on the outcomes of a novel treatment regimen for patients with locally advanced head and neck squamous cell carcinoma who were fit for curative treatment but not fit for cisplatin. METHODS AND MATERIALS: Single-arm phase 1/2 study of previously untreated patients with biopsy-proven SCC of the oropharynx, larynx, or hypopharynx. The primary endpoint was feasibility of the regimen, defined as the proportion of patients successfully completing treatment...
February 24, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28475848/beyond-positive-margins-and-extracapsular-extension-evaluating-the-utilization-and-clinical-impact-of-postoperative-chemoradiotherapy-in-resected-locally-advanced-head-and-neck-cancer
#6
Daniel M Trifiletti, Andrew Smith, Nandita Mitra, Surbhi Grover, John N Lukens, Roger B Cohen, Paul Read, William M Mendenhall, Alexander Lin, Samuel Swisher-McClure
Purpose To examine recent utilization and survival outcomes associated with use of adjuvant chemoradiotherapy (CRT) for patients with resected locally advanced head and neck cancer (LAHNC) with negative surgical margins (SM negative) and no extracapsular extension (ECE). Materials and Methods We conducted a retrospective observational cohort study using the National Cancer Database evaluating patients diagnosed in 2004 to 2012 with AJCC stage III to IVB squamous cell carcinoma of the oral cavity, oropharynx, hypopharynx, and larynx treated with definitive surgery and adjuvant radiotherapy (RT) or CRT...
May 10, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28467606/a-prospective-evaluation-of-short-term-dysphagia-after-transoral-robotic-surgery-for-squamous-cell-carcinoma-of-the-oropharynx
#7
William G Albergotti, Jessica Jordan, Keely Anthony, Shira Abberbock, Tamara Wasserman-Wincko, Seungwon Kim, Robert L Ferris, Umamaheswar Duvvuri
BACKGROUND: Transoral robotic surgery (TORS) for oropharyngeal squamous cell carcinoma (OPSCC) has been associated with improved long-term dysphagia symptomatology compared with chemoradiation. Dysphagia in the perioperative period has been inadequately characterized. The objective of this study was to characterize short-term swallowing outcomes after TORS for OPSCC. METHODS: Patients undergoing TORS for OPSCC were enrolled prospectively. The Eating Assessment Tool 10 (EAT-10) was used as a measure of swallowing dysfunction (score >2) and was administered on postoperative day (POD) 1, 7, and 30...
May 3, 2017: Cancer
https://www.readbyqxmd.com/read/28464749/contouring-and-dose-calculation-in-head-and-neck-cancer-radiotherapy-after-reduction-of-metal-artifacts-in-ct-images
#8
Christian Rønn Hansen, Rasmus Lübeck Christiansen, Ebbe Laugaard Lorenzen, Anders Smedegaard Bertelsen, Jon Thor Asmussen, Niels Gyldenkerne, Jesper Grau Eriksen, Jørgen Johansen, Carsten Brink
BACKGROUND: Delineation accuracy of the gross tumor volume (GTV) in radiotherapy planning for head and neck (H&N) cancer is affected by computed tomography (CT) artifacts from metal implants which obscure identification of tumor as well as organs at risk (OAR). This study investigates the impact of metal artifact reduction (MAR) in H&N patients in terms of delineation consistency and dose calculation precision in radiation treatment planning. MATERIAL AND METHODS: Tumor and OAR delineations were evaluated in planning CT scans of eleven oropharynx patients with streaking artifacts in the tumor region preceding curative radiotherapy (RT)...
June 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28463105/prevalence-of-hpv-in-adults-aged-18-69-united-states-2011-2014
#9
Geraldine McQuillan, Deanna Kruszon-Moran, Lauri E Markowitz, Elizabeth R Unger, Ryne Paulose-Ram
Data from the National Health and Nutrition Examination Survey Human papillomavirus (HPV) is the most common sexually transmitted infection in the United States (1). Some HPV types can cause genital warts and are considered low risk, with a small chance for causing cancer. Other types are considered high risk, causing cancer in different areas of the body including the cervix and vagina in women, penis in men, and anus and oropharynx in both men and women (2). This report provides the most recent national estimates of oral HPV prevalence among adults aged 18-69 from the National Health and Nutrition Examination Survey (NHANES) 2011-2014, as well as prevalence of genital HPV among adults aged 18-59 from NHANES 2013-2014...
April 2017: NCHS Data Brief
https://www.readbyqxmd.com/read/28444831/analysis-of-modulation-factor-to-shorten-the-delivery-time-in-helical-tomotherapy
#10
Hidetoshi Shimizu, Koji Sasaki, Hiroyuki Tachibana, Natsuo Tomita, Chiyoko Makita, Kuniyasu Nakashima, Kazushi Yokoi, Takashi Kubota, Manabu Yoshimoto, Tohru Iwata, Takeshi Kodaira
A low modulation factor (MF) maintaining a good dose distribution contributes to the shortening of the delivery time and efficiency of the treatment plan in helical tomotherapy. The purpose of this study was to reduce the delivery time using initial values and the upper limit values of MF. First, patients with head and neck cancer (293 cases) or prostate cancer (181 cases) treated between June 2011 and July 2015 were included in the analysis of MF values. The initial MF value (MFinitial ) was defined as the average MFactual value, and the upper limit of the MF value (MFUL ) was defined according the following equation: MFUL = 2 × standard deviation of MFactual value + the average MFactual Next, a treatment plan was designed for patients with head and neck cancer (62 cases) and prostate cancer (13 cases) treated between December 2015 and June 2016...
April 26, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28440978/methylation-status-of-p16ink4a-in-human-papillomavirus-associated-cancer-of-oral-cavity-and-oropharynx-in-northeastern-thailand
#11
Piyawut Swangphon, Chamsai Pientong, Ati Burassakarn, Patravoot Vatanasapt, Pilaiwan Kleebkaow, Natcha Patarapadungkit, Thanabut Treebupachatsakul, Supannee Promthet, Bunkerd Kongyingyoes, Tipaya Ekalaksananan
Background: Over-expression of p16INK4a protein is a biomarker for human papillomavirus (HPV)-associated cervical cancer. However, absence of p16INK4a protein expression in HPV-associated cancer of the oral cavity and oropharynx has been reported. Among a number of possible reasons for this is methylation, which is frequently noted in the promoter region of p16INK4a and is associated with silencing of the gene and disease severity. Methods: We investigated the relationships between p16INK4a protein expression, HPV infection and methylation status of the p16INK4a promoter in cancers of the oral cavity and oropharynx...
March 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28438879/definitive-intensity-modulated-radiation-therapy-in-elderly-patients-with-locally-advanced-oropharyngeal-cancer
#12
Francesca DE Felice, Alessandro Galdieri, Gessica Abate, Nadia Bulzonetti, Daniela Musio, Vincenzo Tombolini
BACKGROUND: To evaluate the treatment tolerance and clinical outcomes in patients aged 70 years and older with locally advanced oropharyngeal cancer treated by definitive intensity-modulated radiation therapy (IMRT). PATIENTS AND METHODS: We retrospectively analyzed 15 consecutive elderly patients, with histologically-proven squamous cell carcinoma of the oropharynx, staged T3-4 with or without involved lymph nodes at diagnosis, who received definitive sequential IMRT (70 Gy; 2 Gy/fraction)...
May 2017: In Vivo
https://www.readbyqxmd.com/read/28438295/risk-factors-for-oropharynx-cancer-in-a-cohort-of-hiv-infected-veterans
#13
Erin Y Chew, Christine M Hartman, Peter A Richardson, Jose P Zevallos, Andrew G Sikora, Jennifer R Kramer, Elizabeth Y Chiao
OBJECTIVE: To evaluate HIV-related and other clinical risk factors associated with oropharynx cancer (OPSCC) in HIV-infected U.S. Veterans. METHODS: Retrospective cohort study utilizing Veterans Affairs HIV Clinical Case Registry (CCR) data from 1985 to 2010. Outcome was incident OPSCC as indicated by 1 inpatient or 2 outpatient ICD-9 codes. Cox proportional hazard models were used to determine hazard ratios (HR) and 95% confidence intervals (CI) for each risk factor on the time to OPSCC diagnosis...
May 2017: Oral Oncology
https://www.readbyqxmd.com/read/28438289/impact-of-fraction-size-on-locally-advanced-oropharyngeal-and-nasopharyngeal-cancers-treated-with-chemoradiation
#14
Michael T Spiotto, Matthew Koshy
OBJECTIVES: Although chemoradiation regimens have used various fraction sizes, it remains unclear how differences in fraction size impact outcomes. MATERIALS AND METHODS: Using the National Cancer Database, we identified patients with nasopharynx or oropharynx cancers treated between 2004 and 2012 with chemoradiation using fraction sizes of 1.8Gy (n=1612), 2Gy (n=8092) or 2.12Gy (n=1660). Comparisons between fraction sizes were made in the entire cohort and in a propensity matched cohort...
May 2017: Oral Oncology
https://www.readbyqxmd.com/read/28437239/tprevalence-of-hpv-in-adults-aged-18-69-united-states-2011-2014
#15
Geraldine McQuillan, Deanna Kruszon-Moran, Lauri E Markowitz, Elizabeth R Unger, Ryne Paulose-Ram
Data from the National Health and Nutrition Examination Survey ● During 2011-2014, prevalence of any oral human papillomavirus (HPV) for adults aged 18-69 was 7.3%; high-risk HPV was 4.0%. ● Overall, prevalence of any and high-risk oral HPV was lowest among non-Hispanic Asian adults; any oral HPV was highest among non-Hispanic black adults. ● Prevalence of any and high-risk oral HPV was higher in men than women except for high-risk HPV among Asian adults. ● During 2013-2014, prevalence of any and high-risk genital HPV for adults aged 18-59 was 45...
April 2017: NCHS Data Brief
https://www.readbyqxmd.com/read/28434660/reduced-dose-radiotherapy-for-human-papillomavirus-associated-squamous-cell-carcinoma-of-the-oropharynx-a-single-arm-phase-2-study
#16
Allen M Chen, Carol Felix, Pin-Chieh Wang, Sophia Hsu, Vincent Basehart, Jordan Garst, Phillip Beron, Deborah Wong, Michael H Rosove, Shyam Rao, Heather Melanson, Edward Kim, Daphne Palmer, Lihong Qi, Karen Kelly, Michael L Steinberg, Patrick A Kupelian, Megan E Daly
BACKGROUND: Head and neck cancers positive for human papillomavirus (HPV) are exquisitely radiosensitive. We investigated whether chemoradiotherapy with reduced-dose radiation would maintain survival outcomes while improving tolerability for patients with HPV-positive oropharyngeal carcinoma. METHODS: We did a single-arm, phase 2 trial at two academic hospitals in the USA, enrolling patients with newly diagnosed, biopsy-proven stage III or IV squamous-cell carcinoma of the oropharynx, positive for HPV by p16 testing, and with Zubrod performance status scores of 0 or 1...
April 20, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28423662/comparative-analysis-of-hpv16-gene-expression-profiles-in-cervical-and-in-oropharyngeal-squamous-cell-carcinoma
#17
Andrea Cerasuolo, Clorinda Annunziata, Marianna Tortora, Noemy Starita, Giovanni Stellato, Stefano Greggi, Maria Grazia Maglione, Franco Ionna, Simona Losito, Gerardo Botti, Luigi Buonaguro, Franco M Buonaguro, Maria Lina Tornesello
Human papillomavirus type 16 (HPV16) is the major cause of cervical cancer and of a fraction of oropharyngeal carcinoma. Few studies compared the viral expression profiles in the two types of tumor. We analyzed HPV genotypes and viral load as well as early (E2/E4, E5, E6, E6*I, E6*II, E7) and late (L1 and L2) gene expression of HPV16 in cervical and oropharyngeal cancer biopsies. The study included 28 cervical squamous cell carcinoma (SCC) and ten oropharyngeal SCC, along with pair-matched non-tumor tissues, as well as four oropharynx dysplastic tissues and 112 cervical intraepithelial neoplasia biopsies...
March 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28418447/association-of-oral-cavity-and-oropharyngeal-cancer-biomarkers-in-surgical-drain-fluid-with-patient-outcomes
#18
Amy Anne D Lassig, Anne M Joseph, Bruce R Lindgren, Bevan Yueh
Importance: Survival rates for head and neck cancer have been relatively stable for several decades. Individualized prognostic indicators are needed to identify patients at risk for poorer outcomes. Objective: To determine whether biomarker levels in surgical drain fluid of patients with head and neck cancer are associated with poor cancer outcomes. Design, Setting, and Participants: This prospective cohort study enrolled patients with squamous cell carcinoma (SCC) of the oral cavity and oropharynx who required surgical treatment from April 1, 2011, to February 1, 2016, at a tertiary or academic care center...
April 13, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28409743/pet-neck-a-multicentre-randomised-phase-iii-non-inferiority-trial-comparing-a-positron-emission-tomography-computerised-tomography-guided-watch-and-wait-policy-with-planned-neck-dissection-in-the-management-of-locally-advanced-n2-n3-nodal-metastases-in-patients
#19
Hisham Mehanna, Chris C McConkey, Joy K Rahman, Wai-Lup Wong, Alison F Smith, Chris Nutting, Andrew Gj Hartley, Peter Hall, Claire Hulme, Dharmesh K Patel, Sandra Ventorin von Zeidler, Max Robinson, Bal Sanghera, Lydia Fresco, Janet A Dunn
BACKGROUND: Planned neck dissection (ND) after radical chemoradiotherapy (CRT) for locally advanced nodal metastases in patients with head and neck squamous cell carcinoma (HNSCC) remains controversial. Thirty per cent of ND specimens show histological evidence of tumour. Consequently, a significant proportion of clinicians still practise planned ND. Fludeoxyglucose positron emission tomography (PET)-computerised tomography (CT) scanning demonstrated high negative predictive values for persistent nodal disease, providing a possible alternative paradigm to ND...
April 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/28407983/predictors-affecting-quality-of-life-in-patients-with-upper-aerodigestive-tract-cancers-a-case-control-study-from-india
#20
Bhawna Gupta, Narinder Kumar, Newell W Johnson
OBJECTIVE: The aim of this study was to measure quality of life (QOL) in patients with upper aerodigestive tract (UADT) cancer in comparison with hospital-based controls. We also assessed the impact of various clinical predictors at time of diagnosis of disease/cancer on QOL in these patients. STUDY DESIGN: A case-control study was conducted (N = 480) with 240 UADT cancer cases and 240 controls matched by gender and age (≥5 years) from 2 different hospitals in Pune, India...
May 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
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