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https://www.readbyqxmd.com/read/28926591/no-evidence-for-the-presence-of-epstein-barr-virus-in-squamous-cell-carcinoma-of-the-mobile-tongue
#1
Torben Wilms, Gulfaraz Khan, Philip J Coates, Nicola Sgaramella, Robin Fåhraeus, Asma Hassani, Pretty S Philip, Lena Norberg Spaak, Luigi Califano, Giuseppe Colella, Katarina Olofsson, Christos Loizou, Renato Franco, Karin Nylander
Squamous cell carcinoma of the head and neck (SCCHN) comprises a large group of cancers in the oral cavity and nasopharyngeal area that typically arise in older males in association with alcohol/tobacco usage. Within the oral cavity, the mobile tongue is the most common site for tumour development. The incidence of tongue squamous cell carcinoma (TSCC) is increasing in younger people, which has been suggested to associate with a viral aetiology. Two common human oncogenic viruses, human papilloma virus (HPV) and Epstein-Barr virus (EBV) are known causes of certain types of SCCHN, namely the oropharynx and nasopharynx, respectively...
2017: PloS One
https://www.readbyqxmd.com/read/28895886/immunopathogenesis-of-hpv-associated-cancers-and-prospects-for-immunotherapy
#2
REVIEW
Sigrun Smola
Human papillomavirus (HPV) infection is a causative factor for various cancers of the anogenital region and oropharynx, and is supposed to play an important cofactor role for skin carcinogenesis. Evasion from immunosurveillance favors viral persistence. However, there is evidence that the mere presence of oncogenic HPV is not sufficient for malignant progression and that additional tumor-promoting steps are required. Recent studies have demonstrated that HPV-transformed cells actively promote chronic stromal inflammation and conspire with cells in the local microenvironment to promote carcinogenesis...
September 12, 2017: Viruses
https://www.readbyqxmd.com/read/28894823/the-benefit-of-adjuvant-radiation-in-surgically-treated-t1-2-n1-oropharyngeal-squamous-cell-carcinoma
#3
Marcus M Monroe, Luke O Buchmann, Jason P Hunt, Ying J Hitchcock, Shane Lloyd, Mia Hashibe
IMPORTANCE: The benefit of adjuvant radiation in surgically treated T1-2N1 oropharyngeal cancer without adverse pathologic features remains unclear. OBJECTIVES: To compare population-level survival outcomes in surgically-treated T1-2N1 oropharyngeal squamous cell carcinoma (OPSCC) with and without the use of adjuvant radiation. STUDY DESIGN: Retrospective population-based study using the Surveillance, Epidemiology, and End Results (SEER) registry data from 1998-2011...
April 2017: Laryngoscope Investigative Otolaryngology
https://www.readbyqxmd.com/read/28885213/presentation-of-a-variation-of-the-chorioallantoic-membrane-set-up-as-a-potential-model-for-individual-therapy-for-squamous-cell-carcinoma-of-the-oropharynx
#4
P Kauffmann, M Troeltzsch, R Cordesmeyer, P I Heidekrueger, H Schliephake, M Canis, H A Wolff, M Rave-Fraenk, P Stroebel, A Kehrer, L Prantl, T Aung
The chorioallantoic membrane of fertilized chicken eggs in an early phase of breeding presents an approved test situation for the growth and treatment of human cancer cells.These models work due to the inoculation of cells into the membrane that stays within the egg shell during the time of investigation. In this study a modification of this model is presented. Samples of native tumors, rather than cell lines, are transplanted into the membrane and the body of the egg is taken out of the shell and placed in a plastic bowl...
September 4, 2017: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/28880679/application-of-nanocarrier-based-drug-delivery-system-in-treatment-of-oral-cancer
#5
Abhishek K Sah, Amber Vyas, Preeti K Suresh, Bina Gidwani
Oral cancer includes cancer of lips, oral cavity and oropharynx. Oral cancer is the sixth most life-threatening disease affecting 65% of population. The delivery of cytotoxic chemotherapeutic anticancer drugs is a challenging task due to unfavorable properties. Both synthetic chemotherapeutic agents and herbal constituents are used in treatment of oral cancer. The purpose of present article is to overcome the limitations through concept of nanotechnology and conjugation approach. Also, it will provide better therapeutic effect and sustain long life of healthy and recovered cells...
September 7, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28877058/nonuniform-distribution-of-high-risk-human-papillomavirus-in-squamous-cell-carcinomas-of-the-oropharynx-rethinking-the-anatomic-boundaries-of-oral-and-oropharyngeal-carcinoma-from-an-oncologic-hpv-perspective
#6
Elise Gelwan, Ian-James Malm, Armen Khararjian, Carol Fakhry, Justin A Bishop, William H Westra
The oral cavity and oropharynx have historically been viewed as a single anatomic compartment of the head and neck. The practice of combining the oral cavity and oropharynx has recently been revised, largely owing to the observation that human papillomavirus (HPV)-related carcinogenesis has a strong predilection for the oropharynx but not the oral cavity. The purpose of this study was to determine whether HPV is evenly distributed across squamous cell carcinomas of the oropharynx including those sites that do not harbor tonsillar tissues such as the soft palate...
September 4, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28865970/-description-of-the-gortec-2017-03-study-postoperative-stereotactic-radiotherapy-for-early-stage-oropharyngeal-and-oral-cavity-cancer-with-high-risk-margin-phrc-k-16-164
#7
J Biau, J Miroir, C Millardet, N Saroul, N Pham-Dang, S Racadot, F Huguet, F Kwiatkowski, B Pereira, J Bourhis, M Lapeyre
The GORTEC 2017-03-Stereo-postop study is a phase 2, multicentric, nationwide study, funded by the hospital clinical research program (PHRC). The sponsor is Centre Jean-Perrin in Clermont-Ferrand, in partnership with the GORTEC. The principal investigators are Dr J Biau and Dr M Lapeyre. The main objective is to study severe late toxicity of postoperative stereotactic radiotherapy (6×6Gy) for early stage oropharyngeal and oral cavity cancer with high risk margins. The secondary objectives include acute toxicity, efficacy, nutritional impact and quality of life...
August 30, 2017: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/28864403/clinical-outcomes-of-several-imrt-techniques-for-patients-with-head-and-neck-cancer-a-propensity-score-weighted-analysis
#8
Jean-Emmanuel Bibault, Sophie Dussart, Pascal Pommier, Magali Morelle, Marius Huguet, Pierre Boisselier, Bernard Coche-Dequeant, Marc Alfonsi, Etienne Bardet, Michel Rives, Valentin Calugaru, Enrique Chajon, Georges Noel, Hinda Mecellem, Stephanie Servagi Vernat, Lionel Perrier, Philippe Giraud
PURPOSE: The Advanced Radiotherapy Oto-Rhino-Laryngologie (ART-ORL) study (NCT02024035) was performed to prospectively evaluate the clinical and economic aspects of helical TomoTherapy and volumetric modulated arc therapy (RapidArc, Varian Medical Systems, Palo Alto, CA) for patients with head and neck cancer. METHODS AND MATERIALS: Fourteen centers participated in this prospective comparative study. Randomization was not possible based on the availability of equipment...
June 27, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28862204/epidemiological-profile-of-head-and-neck-cancer-patients-in-western-uttar-pradesh-and-analysis-of-distributions-of-risk-factors-in-relation-to-site-of-tumor
#9
Mohammad Shadab Alam, Shahid Ali Siddiqui, Roshan Perween
BACKGROUND: Head and neck cancers (HNCs) are a major form of cancers in India. The spectrum varies from place to place within the country because of significant diversified risk factors. AIMS AND OBJECTIVE: To study, epidemiology and risk factors of HNC patients from Western Uttar Pradesh and to find out the correlation between risk factors and different anatomical regions involved. MATERIALS AND METHODS: All patients with histologically confirmed diagnoses of HNC between January 2011 and December 2013 were selected from hospital records...
July 2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28861601/the-role-of-high-risk-human-papillomavirus-infections-in-laryngeal-squamous-cell-carcinoma
#10
REVIEW
Claus Wittekindt, Nora Wuerdemann, Stefan Gattenlöhner, Alexander Brobeil, Malgorzata Wierzbicka, Steffen Wagner, Jens Peter Klußmann
The contribution of human papillomavirus (HPV) to the development and clinical outcome of oropharyngeal cancers has been well documented. The association of HPV in laryngeal squamous cell carcinoma (LSCC) has been examined in several studies, but controversy exists regarding its role in carcinogenesis, the outcome of the patients and thus, clinical significance of HPV testing in LSCC. In this review, we give an update of known associations between HPV-positive testing and carcinogenesis in laryngeal cancer...
August 31, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28829763/did-the-addition-of-concurrent-chemotherapy-to-conventional-radiotherapy-improve-survival-for-patients-with-hpv-ve-and-hpv-ve-oropharynx-cancer-a-population-based-study
#11
Stephen F Hall, Fei-Fei Liu, Brian O'Sullivan, Willa Shi, Susan Rohland, Rebecca Griffiths, Patti Groome
BACKGROUND: In the absence of clear evidence on the efficacy of concurrent chemoradiotherapy (CRT) over conventional radiotherapy (RT) for HPV+ve and for HPV-ve oropharyngeal cancer (OPC), this study compares the treatments and outcomes from pre-CRT years to post-CRT years. METHODS: A population-based retrospective treatment-effectiveness study based on all patients with OPC treated in Ontario Canada in 1998, 1999, 2003 and 2004. Charts were reviewed, tissue samples were requested and tissue was tested for p16 or in situ hybridisation...
August 22, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28815324/alcohol-and-head-and-neck-cancer
#12
Daisuke Kawakita, Keitaro Matsuo
In this article, we reviewed the association between alcohol drinking and head and neck cancer (HNC) and its subsites, using the available literature. Alcohol drinking is an established risk factor for HNC, and this association may be stronger among cancers of the oropharynx and hypopharynx than the oral cavity or larynx. In addition, higher alcohol consumption over a shorter period was more harmful than fewer alcohol consumption over a longer period, and the most frequently consumed alcoholic beverages in a population is likely to be associated with the highest risk of HNC in that population...
August 16, 2017: Cancer Metastasis Reviews
https://www.readbyqxmd.com/read/28797468/incidence-of-and-risk-factors-for-mandibular-osteoradionecrosis-in-patients-with-oral-cavity-and-oropharynx-cancers
#13
Dominic H Moon, Sung Ho Moon, Kyle Wang, Mark C Weissler, Trevor G Hackman, Adam M Zanation, Brian D Thorp, Samip N Patel, Jose P Zevallos, Lawrence B Marks, Bhishamjit S Chera
OBJECTIVES: To evaluate the incidence of, and risk factors associated with, mandibular osteoradionecrosis (MORN) following radiation therapy (RT) for oral cavity and oropharyngeal cancers. MATERIALS AND METHODS: Patient and treatment records of 252 consecutive patients with oral cavity or oropharynx cancers treated with RT by a single radiation oncologist at a high volume academic institution from August 2009 to December 2015 were retrospectively reviewed. A Cox regression model was used to assess factors associated with the development of MORN...
September 2017: Oral Oncology
https://www.readbyqxmd.com/read/28797455/prognostic-factors-and-occult-nodal-disease-in-mucoepidermoid-carcinoma-of-the-oral-cavity-and-oropharynx-an-analysis-of-the-national-cancer-database
#14
Mark A Ellis, Evan M Graboyes, Terry A Day, David M Neskey
OBJECTIVES: Mucoepidermoid carcinoma (MEC) is an uncommon malignancy that most commonly occurs in the parotid gland followed by the minor salivary glands of the upper aerodigestive tract, most notably in the oral cavity (OC) and oropharynx (OP). Because of its rarity, few studies have been performed that are specific to MEC within the OC and OP. The objective of this study is to describe the tumor characteristics and prognostic features for MEC of the OC and OP. MATERIALS AND METHODS: The National Cancer Database (NCDB) was used for this study...
September 2017: Oral Oncology
https://www.readbyqxmd.com/read/28794879/human-papillomavirus-driven-immune-deviation-challenge-and-novel-opportunity-for-immunotherapy
#15
REVIEW
Sigrun Smola, Connie Trimble, Peter L Stern
It is now recognized that the immune system can be a key component of restraint and control during the neoplastic process. Human papillomavirus (HPV)-associated cancers of the anogenital tract and oropharynx represent a significant clinical problem but there is a clear opportunity for immune targeting of the viral oncogene expression that drives cancer development. However, high-risk HPV infection of the target epithelium and the expression of the E6/E7 oncogenes can lead to early compromise of the innate immune system (loss of antigen-presenting cells) facilitating viral persistence and increased risk of cancer...
June 2017: Therapeutic Advances in Vaccines
https://www.readbyqxmd.com/read/28793926/tobacco-and-alcohol-cessation-or-reduction-interventions-in-people-with-oral-dysplasia-and-head-and-neck-cancer-systematic-review-protocol
#16
Ellie Shingler, Luke A Robles, Rachel Perry, Chris Penfold, Andy Ness, Steve Thomas, J Athene Lane, Richard M Martin
BACKGROUND: Head and neck cancers include malignancies of the mouth, larynx and oropharynx. Tobacco use and alcohol consumption are associated with increased risks of developing and dying from head and neck cancer. The aim of this review is to examine the effectiveness of smoking and alcohol cessation interventions on disease-related outcomes, quality of life and behavioural change in adults with head and neck cancer and oral dysplasia. METHODS: The Cochrane library, CINAHL, Embase, MEDLINE, PsycINFO and Web of Science databases will be searched for randomised controlled trials investigating the effects of smoking or alcohol interventions on patients with either head and neck cancer or oral dysplasia...
August 10, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28764811/survival-impact-of-pre-treatment-neutrophils-on-oropharyngeal-and-laryngeal-cancer-patients-undergoing-definitive-radiotherapy
#17
Whitney A Sumner, William A Stokes, Ayman Oweida, Kiersten L Berggren, Jessica D McDermott, David Raben, Diana Abbott, Bernard Jones, Gregory Gan, Sana D Karam
BACKGROUND: Squamous cell carcinoma of the head and neck (HNSCC) represents an array of disease processes with a generally unfavorable prognosis. Inflammation plays an important role in tumor development and response to therapy. We performed a retrospective analysis of HNSCC patients to explore the relationship of the lymphocyte and neutrophil counts, the neutrophil-to-lymphocyte ratio (NLR) overall survival (OS), cancer-specific survival (CSS), local control (LC) and distant control (DC)...
August 2, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28762075/incidence-and-5-year-survival-rate-for-head-and-neck-cancers-in-grenada-compared-to-the-african-american-population-over-the-period-1991-2010
#18
Maira du Plessis, Robert Hage
Very little data exist on the incidence and burden of cancer in the individual Caribbean countries. Some data are available for larger areas, reported under a bigger geographical region; Latin America and the Caribbean, but many of the individual countries are not included. One of the main reasons is a lack of official cancer registries. Data are usually collected from hospital records or private physician records, and since it is not in an official registry, these data are not always accessible for inclusion in databases such as SEER and GLOBOCAN...
July 31, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28758200/endoscopic-screening-for-synchronous-esophageal-neoplasia-among-patients-with-incident-head-and-neck-cancer-prevalence-risk-factors-and-outcomes
#19
Yao-Kuang Wang, Yun-Shiuan Chuang, Tzung-Shiun Wu, Ka-Wo Lee, Che-Wei Wu, Hsiang-Chen Wang, Chie-Tong Kuo, Chien-Hung Lee, Wen-Rei Kuo, Chung-Ho Chen, Deng-Chyang Wu, I-Chen Wu
Esophageal squamous-cell neoplasia (ESCN) is a common second primary neoplasia found in patients with head-and-neck squamous-cell carcinoma (HNSCC). This study sought to identify the risk factors for synchronous ESCN and how they influence survival in HNSCC patient. Eight hundred and fifteen incident HNSCC patients were prospectively recruited for endoscopy screening for ESCN using white-light imaging, narrow-band imaging, Lugol chromoendoscopy, and pathological confirmation. Associated lifestyle and clinicopathological data were collected...
July 30, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28757375/role-of-radiotherapy-fractionation-in-head-and-neck-cancers-march-an-updated-meta-analysis
#20
Benjamin Lacas, Jean Bourhis, Jens Overgaard, Qiang Zhang, Vincent Grégoire, Matthew Nankivell, Björn Zackrisson, Zbigniew Szutkowski, Rafał Suwiński, Michael Poulsen, Brian O'Sullivan, Renzo Corvò, Sarbani Ghosh Laskar, Carlo Fallai, Hideya Yamazaki, Werner Dobrowsky, Kwan Ho Cho, Adam S Garden, Johannes A Langendijk, Celia Maria Pais Viegas, John Hay, Mohamed Lotayef, Mahesh K B Parmar, Anne Aupérin, Carla van Herpen, Philippe Maingon, Andy M Trotti, Cai Grau, Jean-Pierre Pignon, Pierre Blanchard
BACKGROUND: The Meta-Analysis of Radiotherapy in squamous cell Carcinomas of Head and neck (MARCH) showed that altered fractionation radiotherapy is associated with improved overall and progression-free survival compared with conventional radiotherapy, with hyperfractionated radiotherapy showing the greatest benefit. This update aims to confirm and explain the superiority of hyperfractionated radiotherapy over other altered fractionation radiotherapy regimens and to assess the benefit of altered fractionation within the context of concomitant chemotherapy with the inclusion of new trials...
September 2017: Lancet Oncology
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