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Cancer oropharynx

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https://www.readbyqxmd.com/read/29128262/intraoperative-imaging-during-minimally-invasive-transoral-robotic-surgery-using-near-infrared-light
#1
Nicholas Scott-Wittenborn, Ryan S Jackson
PURPOSE: The purpose of this study was to determine if the use of the FIREFLY imaging system could be an asset in transoral robotic surgery (TORS) for oropharyngeal squamous cell carcinoma (OPSCC). The system uses indocyanine green dye (ICG), which fluoresces when illuminated by near-infrared light from the Da Vinci robot. The system may improve visualization of tumor margins, highlight important vascular structures, and help identify the location of tumors and unknown primary head and neck cancers...
September 6, 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/29126495/surgical-management-of-oral-cancer
#2
REVIEW
Rabie M Shanti, Bert W O'Malley
Today, most head and neck cancer subsites, such as the larynx, hypopharynx, nasopharynx, and oropharynx, are treated with radiation therapy with or without chemotherapy as a primary treatment modality. Surgery is reserved for the salvage of recurrent tumors that occur within the head and neck in the absence of distant (ie, lung, liver) metastasis. However, unlike all other head and neck subsites, oral cancer should ideally be managed with primary surgery with the possibility of adjuvant radiation therapy with or without chemotherapy depending on the presence of certain high-risk pathologic features...
January 2018: Dental Clinics of North America
https://www.readbyqxmd.com/read/29118826/prevalence-of-hpv-infection-in-hypopharyngeal-and-laryngeal-squamous-cell-carcinoma-at-thailand-s-largest-tertiary-referral-center
#3
Warut Pongsapich, Nitathip Eakkasem, Sontana Siritantikorn, Paveena Pithuksurachai, Kshidej Bongsabhikul, Cheerasook Chongkolwatana
Background: Following the well-established relationship between human papillomavirus (HPV) and cervical carcinoma, the carcinogenicity of this virus has also been confirmed in subsets of head and neck carcinoma (HNCA), but mainly in the oropharynx. Other subsites of HNCA with less known association to HPV have never been studied in Thailand. Accordingly, the aim of this study was to investigate the prevalence of HPV DNA in hypopharyngeal and laryngeal squamous cell carcinoma in Thai population...
2017: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/29107665/eps8-expression-is-significantly-lower-in-p16-head-and-neck-squamous-cell-carcinomas-hnscc-compared-to-p16-hnscc
#4
Elham Nasri, Lisa B Wiesen, Jacquelyn A Knapik, Kristianna M Fredenburg
In vitro head and neck cancer studies have demonstrated that epidermal growth factor receptor kinase substrate 8 (Eps8) overexpression contributes to squamous carcinogenesis. Oral squamous cell carcinoma studies have correlated Eps8 expression with metastatic disease and poor prognosis. Head and neck squamous cell carcinoma (HNSCC) studies comparing its expression by anatomic site or in in vivo regional metastases have not been performed. In this study, we compared Eps8 expression in HNSCCs arising in the oral cavity (OCSCC) and oropharynx (OPSCC) along with their corresponding regional lymph nodes (LNs) metastases...
October 28, 2017: Human Pathology
https://www.readbyqxmd.com/read/29103758/40-year-incidence-trends-for-oropharyngeal-squamous-cell-carcinoma-in-the-united-states
#5
Nosayaba Osazuwa-Peters, Matthew C Simpson, Sean T Massa, Eric Adjei Boakye, Jastin L Antisdel, Mark A Varvares
OBJECTIVES: To determine differences in oropharyngeal squamous cell carcinoma (OPSCC) incidence between 1975 and 2014 stratified by race, sex, and age. MATERIALS AND METHODS: We obtained age-adjusted OPSCC incidence rates for race and sex groups from 1975 to 2014 using the Surveillance, Epidemiology, and End Results 9 database. We defined OPSCC as cancers of the base of tongue, lingual/palatine tonsil, oropharynx, soft palate, uvula, and Waldeyer's ring. We used Joinpoint analyses to determine incidence trends for race/sex/age groupings...
November 2017: Oral Oncology
https://www.readbyqxmd.com/read/29103745/assessment-of-adjuvant-therapy-in-resected-head-and-neck-cancer-with-high-risk-features
#6
Gaurav S Ajmani, Cheryl C Nocon, Chi-Hsiung Wang, Mihir K Bhayani
OBJECTIVES: Subgroup analysis from two randomized trials showed a survival benefit for adjuvant chemoradiation (CRT) over radiation alone (RT) in patients with extracapsular spread (ECS) of involved lymph nodes and/or positive margins (PM) in resected head and neck cancer (HNSCC). However, results were not analyzed separately for patients with ECS or PM and were not stratified by tumor subsite/HPV status. We therefore sought to determine whether adjuvant CRT is associated with a survival benefit, separately among patients with ECS or PM and stratified by subsite/HPV status...
November 2017: Oral Oncology
https://www.readbyqxmd.com/read/29096895/microbiota-and-breast-cancer
#7
Sridhar Mani
Breast carcinogenesis and/or cancer growth and/or drug sensitivity has a multifactorial etiology-perhaps the least well-characterized aspect being that of the distant environmental influences, namely, the microbiota that inhabit humans. For the purposes of this chapter, and to keep the subject matter well defined, microbiota is defined as bacterial microbes only. In this chapter, the pathways that lead to priming of breast cancer and/or the maintenance of a malignant state and/or influences on drug sensitivity via bacterial influences will be identified and described...
2017: Progress in Molecular Biology and Translational Science
https://www.readbyqxmd.com/read/29083238/critical-weight-loss-in-patients-with-oropharynx-cancer-during-radiotherapy-%C3%A2-chemotherapy
#8
Belinda Vangelov, Rebecca L Venchiarutti, Robert I Smee
Critical weight loss (CWL) defined as ≥5% in one month, is common in patients with oropharynx cancer and identification of patients at risk is challenging. We aimed to investigate if predictors of CWL in this population exist to guide nutritional intervention. Data were collected retrospectively on 134 patients who had radiotherapy (RT) ± concurrent chemotherapy (CRT) ± surgery. Body weights were collected pre-RT and during RT, with percentage weight change measured against baseline. Logistic regression was used to analyze chosen predictors...
October 30, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/29075744/multidisciplinary-clinic-management-of-head-and-neck-cancer
#9
Melanie Townsend, Dorina Kallogjeri, Nicholas Scott-Wittenborn, Katherine Gerull, Stacy Jansen, Brian Nussenbaum
Importance: Contemporary management of head and neck cancer involves professionals from multiple specializations. Streamlined care that reduces delays yet allows for comprehensive evaluation is needed. Objective: To evaluate a single-day, single-appointment, multidisciplinary head and neck clinic model for reduction in treatment delay and comprehensiveness of care. Design, Setting, and Participants: A retrospective cohort analysis was conducted from June 1, 2015, to July 31, 2016, of outpatients at a single, academic medical center...
October 26, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29074172/low-prevalence-of-hpv-driven-head-and-neck-squamous-cell-carcinoma-in-north-east-italy
#10
Lorena Baboci, Dana Holzinger, Paolo Boscolo-Rizzo, Giancarlo Tirelli, Roberto Spinato, Valentina Lupato, Roberto Fuson, Markus Schmitt, Angelika Michel, Gordana Halec, Maria Cristina Da Mosto, Michael Pawlita, Annarosa Del Mistro
OBJECTIVES: To investigate the frequency of Human papillomavirus (HPV)-driven head and neck squamous cell carcinoma (HNSCC) among patients living in North-East Italy, by assessing HPV-DNA positivity in all tumors and additional markers whenever possible. MATERIAL AND METHODS: HPV types, viral load, viral RNA, HPV16/18 E6 protein and p16(INK4a) and pRb expression were determined in primary tumor tissues from 247 HNSCC patients. Tumor-specific HPV seropositivity was analyzed in 102 patients...
December 2016: Papillomavirus Research
https://www.readbyqxmd.com/read/29069791/immunohistochemical-biomarkers-and-volumetric-parameters-for-predicting-radiotherapy-based-outcomes-in-patients-with-p16-negative-pharyngeal-cancer
#11
Rui-Yun Chen, Ying-Chun Lin, Shang-Wen Chen, Tze-Yi Lin, Te-Chun Hsieh, Kuo-Yang Yen, Ji-An Liang, Shih-Neng Yang, Yao-Ching Wang, Ya-Huey Chen, Shu-Fen Chiang, Chia-Hung Kao
BACKGROUND: This study determined the prognostic effects of immunohistochemical biomarkers and volumetric parameters predicting radiotherapy-based treatment in patients with p16-negative squamous cell carcinoma of the oropharynx or hypopharynx. RESULTS: VEGF immunoreactivity > 2 and GLUT1 overexpression were prognostic factors for lower cause-specific survival. Moreover, both factors were associated with lower disease-free survival. The predictors of lower primary relapse-free survival were VEGF immunoreactivity > 2 and CT-based gross tumor volume > 16 mL...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/29067796/risk-factors-of-and-treatments-for-pharyngocutaneous-fistula-occurring-after-oropharynx-and-hypopharynx-reconstruction
#12
Su Bin Do, Chul Hoon Chung, Yong Joon Chang, Byeong Jun Kim, Young Soo Rho
Background: A pharyngocutaneous fistula is a common and difficult-to-manage complication after head and neck reconstruction. It can lead to serious complications such as flap failure, carotid artery rupture, and pharyngeal stricture, and may require additional surgery. Previous radiotherapy, a low serum albumin level, and a higher T stage have been proposed as contributing factors. We aimed to clarify the risk factors for pharyngocutaneous fistula in patients who underwent flap reconstruction and to describe our experiences in treating pharyngocutaneous fistula...
October 25, 2017: Archives of Plastic Surgery
https://www.readbyqxmd.com/read/29061496/sdf-1-cxcr4-expression-is-an-independent-negative-prognostic-biomarker-in-patients-with-head-and-neck-cancer-after-primary-radiochemotherapy
#13
Chiara De-Colle, Apostolos Menegakis, David Mönnich, Stefan Welz, Simon Boeke, Bence Sipos, Falko Fend, Paul-Stefan Mauz, Inge Tinhofer, Volker Budach, Jehad Abu Jawad, Martin Stuschke, Panagiotis Balermpas, Claus Rödel, Anca-Ligia Grosu, Amir Abdollahi, Jürgen Debus, Claus Belka, Ute Ganswindt, Steffi Pigorsch, Stephanie E Combs, Fabian Lohaus, Annett Linge, Mechthild Krause, Michael Baumann, Daniel Zips
INTRODUCTION: Preclinical and clinical data suggest that the chemokine pathway governed by SDF-1 and CXCR4 contributes to a resistant phenotype. This retrospective biomarker study aims to explore the specific prognostic value of SDF-1 and CXCR4 expression in locally advanced head and neck squamous cell carcinomas (HNSCC) treated with primary radiochemotherapy (RT-CT). MATERIAL AND METHODS: Biopsies from 141 HNSCC tumours of the oral cavity, oropharynx and hypopharynx were evaluated for SDF-1 and CXCR4 expression by immunofluorescence...
October 20, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29037233/cancer-incidence-in-germany-attributable-to-human-papillomavirus-in-2013
#14
Nina Buttmann-Schweiger, Yvonne Deleré, Stefanie J Klug, Klaus Kraywinkel
BACKGROUND: It is estimated that a total of 120,000 new cancer cases in men and in women in more developed countries could be avoided if exposure to HPV was prevented. We used the nationwide pool of German population-based cancer registry data to estimate the burden of HPV-attributable cancer in this population for the year 2013. METHODS: Incident cases of cervical cancer, squamous cell carcinoma of the anus, oropharynx (OP), as well as of the vulva, vagina and penis were classified as potentially HPV-associated and identified from the nationwide cancer registry data-pool...
October 16, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29022097/prevalence-of-fibroblast-growth-factor-receptor-1-fgfr1-amplification-in-squamous-cell-carcinomas-of-the-head-and-neck
#15
Till Sebastian Clauditz, Arne Böttcher, Henning Hanken, Kerstin Borgmann, Guido Sauter, Waldemar Wilczak, Tobias Grob, Adrian Münscher
BACKGROUND: FGFR1 is a receptor tyrosine kinases involved in tumor growth signaling, survival, and differentiation in many solid cancer types. There is growing evidence that FGFR1 amplification might predict therapy response to FGFR1 inhibitors in squamous cell lung cancers. To estimate the potential applicability of anti FGFR1 therapies in squamous cell carcinomas of the head and neck, we studied patterns of FGFR1 amplification using fluorescence in situ hybridization (FISH). MATERIALS AND METHODS: A tissue microarray was constructed from 453 primary treatment-naive squamous cell carcinomas of the head and neck regions with histopathological and clinical follow-up data [including oral cavity (n = 222), oropharynx (n = 126), and larynx (n = 105)]...
October 11, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28987748/consequences-of-introducing-geometric-gtv-to-ctv-margin-expansion-in-dahanca-contouring-guidelines-for-head-and-neck-radiotherapy
#16
Christian Rønn Hansen, Jørgen Johansen, Eva Samsøe, Elo Andersen, Jørgen B B Petersen, Kenneth Jensen, Lisbeth J Andersen, Hella M B Sand, Anders S Bertelsen, Cai Grau
BACKGROUND AND PURPOSE: Defining margins around the Gross Tumour Volume (GTV) to create a Clinical Target Volume (CTV) for head and neck cancer radiotherapy has traditionally been based on presumed knowledge of anatomical routes of spread. However, using a concentric geometric expansion around the GTV may be more reproducible. The purpose of this study was to analyse the inter-observer consistency of geometric CTV delineation with adaptation for anatomical boundaries versus anatomically defined CTVs...
October 4, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28986092/population-based-hpv-vaccination-programmes-are-safe-and-effective-2017-update-and-the-impetus-for-achieving-better-global-coverage
#17
REVIEW
Julia M L Brotherton, Paul N Bloem
Persistent oncogenic human papillomavirus (HPV) is the cause of cervical cancer, as well as cancers of the anus, penis, vulva, vagina and oropharynx. There is good evidence that prophylactic HPV vaccines are immunogenic and effective against targeted-type HPV infections and type-specific genital lesions, including high-grade cervical intraepithelial neoplasia (CIN), when administered prior to HPV infection. There is good evidence that HPV vaccines are safe in population usage, with the most frequent adverse event being injection-site reactions...
September 6, 2017: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/28985953/effects-of-biodegradable-hydrogel-spacer-injection-on-contralateral-submandibular-gland-sparing-in-radiotherapy-for-head-and-neck-cancers
#18
Avani D Rao, Stephanie Coquia, Robert De Jong, Christine Gourin, Brandi Page, Diane Latronico, Samson Dah, Lin Su, Stephen Clarke, Jeffrey Schultz, Lauren M Rosati, Carole Fakhry, John Wong, Theodore L DeWeese, Harry Quon, Kai Ding, Ana Kiess
Xerostomia is the most common late toxicity after head and neck radiation. We demonstrate injection of a hydrogel spacer anteriorly displacing the submandibular gland. This procedure enables reduced dose to the displaced submandibular gland in cadaveric models of oropharynx cancer treated with IMRT, with potential implications in reducing xerostomia risk.
October 3, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28978708/suppression-of-microrna-424-levels-by-human-papillomavirus-proteins-is-necessary-for-differentiation-dependent-genome-amplification
#19
Shiyuan Hong, Shouqiang Cheng, William Songock, Jason Bodily, Laimonis A Laimins
High-risk human papillomaviruses (HPVs) link their life cycle to epithelial differentiation and require activation of DNA damage pathways for efficient replication. HPVs modulate the expression of cellular transcription factors as well as cellular miRNAs to control these activities. One miRNA that has been reported to be repressed in HPV positive cancers of the cervix as well as oropharynx is miR-424. Our studies show that miR-424 levels are suppressed in cell lines that stably maintain HPV 31 or 16 episomes as well as cervical cancer lines that contain integrated genomes such as SiHa...
October 4, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28975663/architectural-patterns-of-p16-immunohistochemical-expression-associated-with-cancer-immunity-and-prognosis-of-head-and-neck-squamous-cell-carcinoma
#20
Hyang Joo Ryu, Eun Kyung Kim, Su Jin Heo, Byoung Chul Cho, Hye Ryun Kim, Sun Och Yoon
We evaluated the expression patterns of p16, which is used as a surrogate marker of HPV infection in head and neck squamous cell carcinoma (HNSCC), in regard to their biological and prognostic implications. p16 expression patterns and infiltrated immune cells were analyzed through immunohistochemistry of p16, CD3, CD8, PD-1, FOXP3, and CD163 on surgically resected HNSCCs (n = 393). Patterns of p16 immunoexpression were defined as STRONG (strong, diffuse expression in cytoplasm, and nucleus in >70% of tumor cells), MARGINAL (expression restricted to tumor margins), MOSAIC (ragged, discontinued expression), NUCLEAR (expression in nuclei only), and ABSENT (no expression)...
November 2017: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
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