keyword
https://read.qxmd.com/read/36943348/the-effect-of-implementation-of-guideline-order-bundles-into-a-general-admission-order-set-on-clinical-practice-guideline-adoption-quasi-experimental-study
#21
JOURNAL ARTICLE
Justine Mrosak, Swaminathan Kandaswamy, Claire Stokes, David Roth, Jenna Gorbatkin, Ishaan Dave, Scott Gillespie, Evan Orenstein
BACKGROUND: Clinical practice guidelines (CPGs) and associated order sets can help standardize patient care and lead to higher-value patient care. However, difficult access and poor usability of these order sets can result in lower use rates and reduce the CPGs' impact on clinical outcomes. At our institution, we identified multiple CPGs for general pediatrics admissions where the appropriate order set was used in <50% of eligible encounters, leading to decreased adoption of CPG recommendations...
March 21, 2023: JMIR Medical Informatics
https://read.qxmd.com/read/36914876/the-genetic-basis-of-endometriosis-and-comorbidity-with-other-pain-and-inflammatory-conditions
#22
JOURNAL ARTICLE
Nilufer Rahmioglu, Sally Mortlock, Marzieh Ghiasi, Peter L Møller, Lilja Stefansdottir, Geneviève Galarneau, Constance Turman, Rebecca Danning, Matthew H Law, Yadav Sapkota, Paraskevi Christofidou, Sini Skarp, Ayush Giri, Karina Banasik, Michal Krassowski, Maarja Lepamets, Błażej Marciniak, Margit Nõukas, Danielle Perro, Eeva Sliz, Marta Sobalska-Kwapis, Gudmar Thorleifsson, Nura F Topbas-Selcuki, Allison Vitonis, David Westergaard, Ragnheidur Arnadottir, Kristoffer S Burgdorf, Archie Campbell, Cecilia S K Cheuk, Caterina Clementi, James Cook, Immaculata De Vivo, Amy DiVasta, O Dorien, Jacqueline F Donoghue, Todd Edwards, Pierre Fontanillas, Jenny N Fung, Reynir T Geirsson, Jane E Girling, Paivi Harkki, Holly R Harris, Martin Healey, Oskari Heikinheimo, Sarah Holdsworth-Carson, Isabel C Hostettler, Henry Houlden, Sahar Houshdaran, Juan C Irwin, Marjo-Riitta Jarvelin, Yoichiro Kamatani, Stephen H Kennedy, Ewa Kepka, Johannes Kettunen, Michiaki Kubo, Bartosz Kulig, Venla Kurra, Hannele Laivuori, Marc R Laufer, Cecilia M Lindgren, Stuart MacGregor, Massimo Mangino, Nicholas G Martin, Charoula Matalliotaki, Michail Matalliotakis, Alison D Murray, Anne Ndungu, Camran Nezhat, Catherine M Olsen, Jessica Opoku-Anane, Sandosh Padmanabhan, Manish Paranjpe, Maire Peters, Grzegorz Polak, David J Porteous, Joseph Rabban, Kathyrn M Rexrode, Hanna Romanowicz, Merli Saare, Liisu Saavalainen, Andrew J Schork, Sushmita Sen, Amy L Shafrir, Anna Siewierska-Górska, Marcin Słomka, Blair H Smith, Beata Smolarz, Tomasz Szaflik, Krzysztof Szyłło, Atsushi Takahashi, Kathryn L Terry, Carla Tomassetti, Susan A Treloar, Arne Vanhie, Katy Vincent, Kim C Vo, David J Werring, Eleftheria Zeggini, Maria I Zervou, Sosuke Adachi, Julie E Buring, Paul M Ridker, Thomas D'Hooghe, George N Goulielmos, Dharani K Hapangama, Caroline Hayward, Andrew W Horne, Siew-Kee Low, Hannu Martikainen, Daniel I Chasman, Peter A W Rogers, Philippa T Saunders, Marina Sirota, Tim Spector, Dominik Strapagiel, Joyce Y Tung, David C Whiteman, Linda C Giudice, Digna R Velez-Edwards, Outi Uimari, Peter Kraft, Andres Salumets, Dale R Nyholt, Reedik Mägi, Kari Stefansson, Christian M Becker, Piraye Yurttas-Beim, Valgerdur Steinthorsdottir, Mette Nyegaard, Stacey A Missmer, Grant W Montgomery, Andrew P Morris, Krina T Zondervan
Endometriosis is a common condition associated with debilitating pelvic pain and infertility. A genome-wide association study meta-analysis, including 60,674 cases and 701,926 controls of European and East Asian descent, identified 42 genome-wide significant loci comprising 49 distinct association signals. Effect sizes were largest for stage 3/4 disease, driven by ovarian endometriosis. Identified signals explained up to 5.01% of disease variance and regulated expression or methylation of genes in endometrium and blood, many of which were associated with pain perception/maintenance (SRP14/BMF, GDAP1, MLLT10, BSN and NGF)...
March 2023: Nature Genetics
https://read.qxmd.com/read/36794298/longitudinal-assessment-of-comorbidities-and-co-occurring-conditions-in-adolescents-with-migraine-a-secondary-analysis-of-the-national-longitudinal-study-of-adolescent-to-adult-health-add-health
#23
JOURNAL ARTICLE
James S McGinley, Andrea Savord, Dawn C Buse, R J Wirth, Richard B Lipton
OBJECTIVE: To investigate the links between adolescent migraine and comorbid and co-occurring conditions using a large, nationally representative longitudinal study. BACKGROUND: Comorbidities and co-occurring conditions play an important role in the clinical treatment of individuals with migraine. Research in this area has focused largely on the adult population using cross-sectional data, but less is known about adolescents and how conditions may co-occur over time from a broader developmental perspective...
February 2023: Headache
https://read.qxmd.com/read/36460578/identifying-and-visualising-multimorbidity-and-comorbidity-patterns-in-patients-in-the-english-national-health-service-a-population-based-study
#24
JOURNAL ARTICLE
Valerie Kuan, Spiros Denaxas, Praveetha Patalay, Dorothea Nitsch, Rohini Mathur, Arturo Gonzalez-Izquierdo, Reecha Sofat, Linda Partridge, Amanda Roberts, Ian C K Wong, Melanie Hingorani, Nishi Chaturvedi, Harry Hemingway, Aroon D Hingorani
BACKGROUND: Globally, there is a paucity of multimorbidity and comorbidity data, especially for minority ethnic groups and younger people. We estimated the frequency of common disease combinations and identified non-random disease associations for all ages in a multiethnic population. METHODS: In this population-based study, we examined multimorbidity and comorbidity patterns stratified by ethnicity or race, sex, and age for 308 health conditions using electronic health records from individuals included on the Clinical Practice Research Datalink linked with the Hospital Episode Statistics admitted patient care dataset in England...
November 29, 2022: The Lancet. Digital health
https://read.qxmd.com/read/35984830/identified-risk-factors-for-dry-eye-syndrome-a-systematic-review-and-meta-analysis
#25
JOURNAL ARTICLE
Lijun Qian, Wei Wei
A meta-analytic approach was used to identify potential risk factors for dry eye syndrome. PubMed, Embase, and the Cochrane library were systematically searched for studies investigated the risk factors for dry eye syndrome from their inception until September 2021. The odds ratio (OR) with 95% confidence interval (CI) was calculated using the random-effects model. Forty-eight studies comprising 493,630 individuals were included. Older age (OR: 1.82; P<0.001), female sex (OR: 1.56; P<0.001), other race (OR: 1...
2022: PloS One
https://read.qxmd.com/read/35803012/estimating-the-causal-effect-of-liability-to-disease-on-healthcare-costs-using-mendelian-randomization
#26
JOURNAL ARTICLE
Padraig Dixon, Sean Harrison, William Hollingworth, Neil M Davies, George Davey Smith
Accurate measurement of the effects of disease status on healthcare costs is important in the pragmatic evaluation of interventions but is complicated by endogeneity bias. Mendelian Randomization, the use of random perturbations in germline genetic variation as instrumental variables, can avoid these limitations. We used a novel Mendelian Randomization analysis to model the causal impact on inpatient hospital costs of liability to six prevalent diseases and health conditions: asthma, eczema, migraine, coronary heart disease, Type 2 diabetes, and depression...
June 30, 2022: Economics and Human Biology
https://read.qxmd.com/read/35753900/factors-associated-with-comorbid-epilepsy-in-patients-with-psychogenic-nonepileptic-seizures-a-large-cohort-study
#27
JOURNAL ARTICLE
Andreu Massot-Tarrús, Yeyao Joe Yu, Mashael AlKhateeb, Seyed M Mirsattari
OBJECTIVE: Comorbid epilepsy and psychogenic nonepileptic seizures (PNES) occur in 12-22% of cases and the diagnosis of both simultaneous disorders is challenging. We aimed to identify baseline characteristics that may help distinguish patients with PNES-only from those with comorbid epilepsy. METHODS: We performed a longitudinal cohort study on those patients diagnosed with PNES in our epilepsy monitoring unit (EMU) between May 2001 and February 2011, prospectively followed up until September 2016...
June 23, 2022: Epilepsy & Behavior: E&B
https://read.qxmd.com/read/35729718/factors-associated-with-the-development-of-tinnitus-and-with-the-degree-of-annoyance-caused-by-newly-developed-tinnitus
#28
JOURNAL ARTICLE
Thadé Goderie, Marieke F van Wier, Birgit I Lissenberg-Witte, Paul Merkus, Cas Smits, C René Leemans, Sophia E Kramer
OBJECTIVES: Tinnitus is highly prevalent, but only a few risk factors for developing tinnitus are known and little is known about factors associated with the degree of annoyance of new-onset tinnitus. Longitudinal analysis can reveal risk factors associated with the development of tinnitus and might lead to targeted prevention. The aim of this study is twofold. (1) To identify risk factors that are longitudinally associated with the odds of developing tinnitus 5 years later. (2) To identify factors that are cross-sectionally associated with tinnitus annoyance in adults with new-onset tinnitus...
June 22, 2022: Ear and Hearing
https://read.qxmd.com/read/35703794/patient-factors-associated-with-high-opioid-consumption-after-common-surgical-procedures-following-state-mandated-opioid-prescription-regulations
#29
JOURNAL ARTICLE
Autumn Sacklow, Ajai K Malhotra, Ethan Jones, Peter Callas, Mayo Fujii, Christos Colovos
BACKGROUND: State regulations have decreased prescribed opioids with more than 25% of patients abstaining from opioids. Despite this, 2 distinct populations of patients exist who consume "high" or "low" amounts of opioids. The aim of this study was to identify factors associated with postoperative opioid use after common surgical procedures and develop an opioid risk score. STUDY DESIGN: Patients undergoing 35 surgical procedures from 7 surgical specialties were identified at a 620-bed tertiary care academic center and surveyed 1 week after discharge regarding opioid use and adequacy of analgesia...
June 1, 2022: Journal of the American College of Surgeons
https://read.qxmd.com/read/35516443/associations-of-sedentary-time-and-physical-activity-with-adverse-health-conditions-outcome-wide-analyses-using-isotemporal-substitution-model
#30
JOURNAL ARTICLE
Zhi Cao, Chenjie Xu, Pengjie Zhang, Yaogang Wang
BACKGROUND: As one of the most common lifestyles today, sedentary behaviour is a risk factor for many health conditions. To inform potential behavioural guideline development, we aimed to estimate the theoretical effects of replacing sedentary behaviour with different intensity of physical activity on risks of 45 common non-communicable diseases (NCDs). METHODS: A total of 360,047 participants (aged 37-73 years) in the UK Biobank free of the 45 common non-communicable diseases (NCDs) were included...
June 2022: EClinicalMedicine
https://read.qxmd.com/read/35514537/insights-from-genomic-studies-on-the-role-of-sex-steroids-in-the-aetiology-of-endometriosis
#31
REVIEW
Philippa T K Saunders
Endometriosis is a chronic neuro-inflammatory disorder the defining feature of which is the growth of tissue (lesions) that resembles the endometrium outside the uterus. Estimates of prevalence quote rates of ~10% of women of reproductive age, equating to at least 190 million women world-wide. Genetic, hormonal and immunological factors have all been proposed as contributing to risk factors associated with the development of lesions. Twin studies report the heritable component of endometriosis as ~50%. Genome-wide association studies (GWAS) have identified single nucleotide polymorphisms (SNPs) that appear over-represented in patients with endometriosis, particularly those with more extensive disease (stage III/IV)...
April 1, 2022: Reproduction & fertility
https://read.qxmd.com/read/35366670/increased-risk-of-migraine-among-students-with-asthma-results-of-headache-and-asthma-study-among-university-students
#32
JOURNAL ARTICLE
O O Desalu, E O Sanya, A O Adeoti, O B Ojuawo, A O Aladesanmi, J K Olarinoye, O J Afolayan
BACKGROUND: Several studies in developed countries have investigated the relationship between migraine and asthma. OBJECTIVE: To examine the relationship between asthma and migraine among university students in a low middle-income country. METHODS: We conducted a cross-sectional study across three universities in the middle belt region of Nigeria. A self-administered questionnaire developed from the International Classification of Headache Disorders was used to screen for migraine...
March 30, 2022: West African Journal of Medicine
https://read.qxmd.com/read/35074819/mapping-multimorbidity-in-individuals-with-schizophrenia-and-bipolar-disorders-evidence-from-the-south-london-and-maudsley-nhs-foundation-trust-biomedical-research-centre-slam-brc-case-register
#33
JOURNAL ARTICLE
Rebecca Bendayan, Zeljko Kraljevic, Shaweena Shaari, Jayati Das-Munshi, Leona Leipold, Jaya Chaturvedi, Luwaiza Mirza, Sarah Aldelemi, Thomas Searle, Natalia Chance, Aurelie Mascio, Naoko Skiada, Tao Wang, Angus Roberts, Robert Stewart, Daniel Bean, Richard Dobson
OBJECTIVES: The first aim of this study was to design and develop a valid and replicable strategy to extract physical health conditions from clinical notes which are common in mental health services. Then, we examined the prevalence of these conditions in individuals with severe mental illness (SMI) and compared their individual and combined prevalence in individuals with bipolar (BD) and schizophrenia spectrum disorders (SSD). DESIGN: Observational study. SETTING: Secondary mental healthcare services from South London PARTICIPANTS: Our maximal sample comprised 17 500 individuals aged 15 years or older who had received a primary or secondary SMI diagnosis (International Classification of Diseases, 10th edition, F20-31) between 2007 and 2018...
January 24, 2022: BMJ Open
https://read.qxmd.com/read/34983769/biological-and-clinical-correlates-of-the-patient-health-questionnaire-9-exploratory-cross-sectional-analyses-of-the-baseline-health-study
#34
JOURNAL ARTICLE
Robert M Califf, Celeste Wong, P Murali Doraiswamy, David S Hong, David P Miller, Jessica L Mega
OBJECTIVES: We assessed the relationship between the Patient Health Questionnaire-9 (PHQ-9) at intake and other measurements intended to assess biological factors, markers of disease and health status. DESIGN, SETTING AND PARTICIPANTS: We performed a cross-sectional analysis of 2365 participants from the Baseline Health Study, a prospective cohort of adults selected to represent major demographic groups in the USA. Participants underwent deep phenotyping on demographic, clinical, laboratory, functional and imaging findings...
January 4, 2022: BMJ Open
https://read.qxmd.com/read/34901908/depressive-symptoms-during-early-adulthood-and-the-development-of-physical-multimorbidity-in-the-uk-an-observational-cohort-study
#35
JOURNAL ARTICLE
Jorge Arias-de la Torre, Amy Ronaldson, Matthew Prina, Faith Matcham, Snehal M Pinto Pereira, Stephani L Hatch, David Armstrong, Andrew Pickles, Matthew Hotopf, Alex Dregan
BACKGROUND: An understanding of whether early-life depression is associated with physical multimorbidity could be instrumental for the development of preventive measures and the integrated management of depression. We therefore aimed to map out the cumulative incidence of physical multimorbidity over adulthood, and to determine the association between the presence of depressive symptoms during early adulthood and the development of physical multimorbidity in middle age. METHODS: In this observational cohort study, we used pooled data from the 1958 National Child Development Study (NCDS) and the 1970 British Cohort Study (BCS)...
December 2021: The Lancet. Healthy longevity
https://read.qxmd.com/read/34757108/non-mental-diseases-associated-with-adhd-across-the-lifespan-fidgety-philipp-and-pippi-longstocking-at-risk-of-multimorbidity
#36
REVIEW
Sarah Kittel-Schneider, Gara Arteaga-Henriquez, Alejandro Arias Vasquez, Phil Asherson, Tobias Banaschewski, Isabell Brikell, Jan Buitelaar, Bru Cormand, Stephen V Faraone, Christine M Freitag, Ylva Ginsberg, Jan Haavik, Catharina A Hartman, Jonna Kuntsi, Henrik Larsson, Silke Matura, Rhiannon V McNeill, J Antoni Ramos-Quiroga, Marta Ribases, Marcel Romanos, Isabella Vainieri, Barbara Franke, Andreas Reif
Several non-mental diseases seem to be associated with an increased risk of ADHD and ADHD seems to be associated with increased risk for non-mental diseases. The underlying trajectories leading to such brain-body co-occurrences are often unclear - are there direct causal relationships from one disorder to the other, or does the sharing of genetic and/or environmental risk factors lead to their occurring together more frequently or both? Our goal with this narrative review was to provide a conceptual synthesis of the associations between ADHD and non-mental disease across the lifespan...
January 2022: Neuroscience and Biobehavioral Reviews
https://read.qxmd.com/read/34640387/towards-a-consensus-on-alzheimer-s-disease-comorbidity
#37
REVIEW
Iska Avitan, Yudit Halperin, Trishna Saha, Naamah Bloch, Dana Atrahimovich, Baruh Polis, Abraham O Samson, Ori Braitbard
Alzheimer's disease (AD) is often comorbid with other pathologies. First, we review shortly the diseases most associated with AD in the clinic. Then we query PubMed citations for the co-occurrence of AD with other diseases, using a list of 400 common pathologies. Significantly, AD is found to be associated with schizophrenia and psychosis, sleep insomnia and apnea, type 2 diabetes, atherosclerosis, hypertension, cardiovascular diseases, obesity, fibrillation, osteoporosis, arthritis, glaucoma, metabolic syndrome, pain, herpes, HIV, alcoholism, heart failure, migraine, pneumonia, dyslipidemia, COPD and asthma, hearing loss, and tobacco smoking...
September 24, 2021: Journal of Clinical Medicine
https://read.qxmd.com/read/34626489/prevalence-symptoms-and-risk-factor-profile-of-rumination-syndrome-and-functional-dyspepsia-a-population-based-study
#38
JOURNAL ARTICLE
Mudar Zand Irani, Michael P Jones, Magnus Halland, Linda Herrick, Rok Seon Choung, Yuri A Saito Loftus, Marjorie M Walker, Joseph A Murray, Nicholas J Talley
BACKGROUND: Rumination syndrome is a functional gastroduodenal disorder characterised by effortless regurgitation of recently ingested food. Emerging evidence reports duodenal eosinophilic inflammation in a subset, suggesting a shared pathophysiology with functional dyspepsia (FD). AIM: To assess the clinical features of rumination syndrome and FD in a community-based study. METHODS: We mailed a survey assessing gastrointestinal symptoms, diet and psychological symptoms to 9835 residents of Olmsted County, MN, USA in 2017-2018; diagnostic codes were obtained from linked clinical records...
December 2021: Alimentary Pharmacology & Therapeutics
https://read.qxmd.com/read/34529912/neurological-susceptibility-to-environmental-exposures-pathophysiological-mechanisms-in-neurodegeneration-and-multiple-chemical-sensitivity
#39
REVIEW
John Molot, Margaret Sears, Lynn Margaret Marshall, Riina I Bray
The World Health Organization lists air pollution as one of the top five risks for developing chronic non-communicable disease, joining tobacco use, harmful use of alcohol, unhealthy diets and physical inactivity. This review focuses on how host defense mechanisms against adverse airborne exposures relate to the probable interacting and overlapping pathophysiological features of neurodegeneration and multiple chemical sensitivity. Significant long-term airborne exposures can contribute to oxidative stress, systemic inflammation, transient receptor subfamily vanilloid 1 (TRPV1) and subfamily ankyrin 1 (TRPA1) upregulation and sensitization, with impacts on olfactory and trigeminal nerve function, and eventual loss of brain mass...
December 16, 2022: Reviews on Environmental Health
https://read.qxmd.com/read/34464877/revisiting-the-bipolar-disorder-with-migraine-phenotype-clinical-features-and-comorbidity
#40
JOURNAL ARTICLE
Francisco Romo-Nava, Thomas Blom, Alfredo B Cuellar-Barboza, Oluwole O Awosika, Brian E Martens, Nicole N Mori, Colin L Colby, Miguel L Prieto, Marin Veldic, Balwinder Singh, Manuel Gardea-Resendez, Nicolas A Nunez, Aysegul Ozerdem, Joanna M Biernacka, Mark A Frye, Susan L McElroy
INTRODUCTION: To evaluate the prevalence and clinical correlates of lifetime migraine among patients with bipolar disorder (BD). METHODS: In a cross-sectional study, we evaluated 721 adults with BD from the Mayo Clinic Bipolar Disorder Biobank and compared clinical correlates of those with and without a lifetime history of migraine. A structured clinical interview (DSM-IV) and a clinician-assessed questionnaire were utilized to establish a BD diagnosis, lifetime history of migraine, and clinical correlates...
December 1, 2021: Journal of Affective Disorders
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