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https://www.readbyqxmd.com/read/28239823/inhibitory-effect-and-mechanism-of-metformin-on-human-ovarian-cancer-cells-skov-3-and-a2780
#1
J Huo, X-H Bian, Y Huang, Z-C Miao, L-H Song
OBJECTIVE: Ovarian cancer is the most common malignant tumor in female reproductive system. Metformin is an orally taken hypoglycemic agent, which is extensively applied in the clinic. Clinical trials find that there may be a certain degree of action of the metformin in inhibiting malignant tumors. This paper aims to investigate the inhibitory effect and mechanism of metformin on human ovarian cancer cells. MATERIALS AND METHODS: Through in vitro cell experiment, the influences of metformin on the proliferation, colony formation and apoptosis of ovarian carcinoma cells were studied...
February 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28238911/anti-hyperglycemic-activity-of-polysaccharides-from-calyx-of-physalis-alkekengi-var-franchetii-makino-on-alloxan-induced-mice
#2
Yu Guo, Sujuan Li, Jianxin Li, Zhiyuan Ren, Feng Chen, Xiaowen Wang
The present study was undertaken to investigate the hypoglycemic effect of polysaccharides (PPSC) isolated from calyx of Physalis alkekengi var. franchetii Makino in alloxan-induced diabetic mice. Seven polysaccharide fractions were obtained through a DEAE-52 column and Sephadex G-100 gel column and they were the main composes of PPSC. The PPSC treatment could prevent the loss of body weight in diabetic mice and result in a decrease of fasting blood glucose (FBG) and glycated serum protein (GSP) and an increase of fasting serum insulin in a dose-dependent manner...
February 23, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28236721/self-monitoring-of-blood-glucose-among-patients-with-diabetes-in-jordan-perception-adherence-and-influential-factors
#3
Maha S Al-Keilani, Basima A Almomani, Nour A Al-Sawalha, Batool A Shhabat
AIMS: To investigate the self-monitoring of blood glucose (SMBG) adherence among Jordanian patients with diabetes and to identify the predictive factors. METHODS: A cross-sectional survey was carried out in 18 hospitals and healthcare centers covering south, north, and middle of Jordan. All patients with diabetes attending endocrinology clinics from May to December, 2015 were approached. The questionnaires were distributed by trained pharmacists and were self-administered...
January 17, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28235848/patients-with-long-qt-syndrome-due-to-impaired-herg-encoded-kv11-1-potassium-channel-have-exaggerated-endocrine-pancreatic-and-incretin-function-associated-with-reactive-hypoglycemia
#4
Louise Hyltén-Cavallius, Eva W Iepsen, Nicolai J Wewer Albrechtsen, Mathilde Svendstrup, Anniek F Lubberding, Bolette Hartmann, Thomas Jespersen, Allan Linneberg, Michael Christiansen, Henrik Vestergaard, Oluf Pedersen, Jens J Holst, Jørgen K Kanters, Torben Hansen, Signe S Torekov
Background -Loss-of-function mutations in hERG (encoding the Kv11.1 voltage-gated potassium channel) cause long QT syndrome (LQT2) due to prolonged cardiac repolarization. However, Kv11.1 is also present in pancreatic α and β cells and intestinal L and K cells, secreting glucagon, insulin, and the incretins glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), respectively. These hormones are crucial for glucose regulation and LQTS may cause disturbed glucose regulation. We measured secretion of these hormones and cardiac repolarization in response to glucose ingestion in LQT2 patients with functional mutations in hERG and matched healthy participants, testing the hypothesis that LQT2 patients have increased incretin and β cell- and decreased α cell function and thus lower glucose levels...
February 24, 2017: Circulation
https://www.readbyqxmd.com/read/28235688/effects-of-cymodocea-nodosa-extract-on-metabolic-disorders-and-oxidative-stress-in-alloxan-diabetic-rats
#5
Rihab Ben Abdallah Kolsi, Hichem Ben Salah, Neila Jardak, Rim Chaaben, Abdelfattah El Feki, Tarak Rebai, Kamel Jamoussi, Noureddine Allouche, Hafedh Belghith, Karima Belghith
This new study aimed to evaluate for the first time the effect of Cymodocea nodosa extract (CNE) on α-amylase activity, hyperglycemia and diabetes complications in the alloxan-induced diabetic rats. The in vitro evaluation and oral administration of CNE to surviving diabetic rats inhibited key enzyme related to hyperglycemia as α-amylase, helped to protect the β cells of the rats from death and damage confirmed by oral glucose test tolerance (OGTT), which leads to decrease in blood glucose level by 49% as compared to untreated diabetic rats...
February 21, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28230360/capsaicin-reduces-blood-glucose-by-increasing-insulin-levels-and-glycogen-content-better-than-capsiate-in-streptozotocin-induced-diabetic-rats
#6
Shiqi Zhang, Xiaohan Ma, Zhang Lei, Hui Sun, Xiong Liu
Chili peppers exhibit anti-obesity, anti-cancer, anti-diabetic, and pain- and itchiness-relieving effects on animals and humans; these effects are due to capsaicin, which is the main pungent and biologically active component of pepper. Capsiate, a nonpungent capsaicin analogue and is similar to capsaicin in terms of structure and biological activity. In this study, we investigated whether capsaicin and capsiate exhibit the same hypoglycemic effects on rats with type 1 diabetes (T1D). Experimental rats were categorized into four groups: control, model, capsaicin, and capsiate groups...
February 23, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28225851/effect-of-bauhinia-holophylla-treatment-in-streptozotocin-induced-diabetic-rats
#7
Marcelo S Pinheiro, Luhara S Rodrigues, Leila S, Rafaianne Q Moraes-Souza, Thaigra S Soares, Madileine F Américo, Kleber E Campos, Débora C Damasceno, Gustavo T Volpato
Bauhinia holophylla, commonly known as "cow's hoof", is widely used in Brazilian folk medicine for the diabetes treatment. Therefore, the aim of this study was at evaluating the aqueous extract effect of Bauhinia holophylla leaves treatment on the streptozotocin-induced diabetic rats. Diabetes was induced by Streptozotocin (40 mg/Kg) in female Wistar rats. Oral administration of aqueous extract of Bauhinia holophylla leaves was given to non-diabetic and diabetic rats at a dose of 400 mg/kg during 21 days. On day 17 of treatment, the Oral Glucose Tolerance Test was performed to determine the area under the curve...
February 16, 2017: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/28223777/phloretin-exerts-hypoglycemic-effect-in-streptozotocin-induced-diabetic-rats-and-improves-insulin-resistance-in-vitro
#8
Xin Shen, Nan Zhou, Le Mi, Zishuo Hu, Libin Wang, Xueying Liu, Shengyong Zhang
The present study investigated the possible antiobesity and hypoglycemic effects of phloretin (Ph). In an attempt to discover the hypoglycemic effect and potential mechanism of Ph, we used the streptozotocin-induced diabetic rats and (L6) myotubes. Daily oral treatment with Ph for 4 weeks significantly (P<0.05) reduced postprandial blood glucose and improved islet injury and lipid metabolism. Glucose consumption and glucose tolerance were improved by Ph via GOD-POD method. Western blot results revealed that the expression of Akt, PI3K, IRS-1, and GLUT4 were upregulated in skeletal muscle of type 2 diabetes (T2D) rats and in L6 myotubes by Ph...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28223245/potential-of-single-cationic-amino-acid-molecule-arginine-for-stimulating-oral-absorption-of-insulin
#9
Noriyasu Kamei, El-Sayed Khafagy, Jun Hirose, Mariko Takeda-Morishita
We have reported that cell-penetrating peptides, such as oligoarginine, act as powerful absorption enhancers for the development of oral insulin delivery systems. However, the minimal essential sequence of oligoarginine that stimulates intestinal insulin absorption remains unclear. Therefore, the present study was conducted to clarify this minimum sequence of oligoarginine and to examine the effect of single cationic amino acid arginine on the intestinal and oral absorption of insulin. The results demonstrated that a remarkable enhancement of intestinal insulin absorption was observed after coadministration of insulin with l-arginine...
February 18, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28217528/how-many-oral-antidiabetic-drugs-before-insulin
#10
Jayant Kelwade, Harsh Parekh, Vaibhav Dukle, Bipin Kumar Sethi
Worsening of glycemic control in type 2 Diabetes mellitus occur on account of declining beta cell function. This calls for up titration of the chosen drug, addition of another agent with complementary action and eventually insulin usually after 2 or three OADs. Introduction of insulin has many issues which include parenteral route of administration, cost and enhancement of hypoglycemic tendency. We propose the addition of another OAD in lieu of insulin in whom glycemic control can be achieved equally well without insulin...
January 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28217515/reported-hypoglycemia-in-type-2-diabetes-mellitus-patients-prevalence-and-practices-a-hospital-based-study
#11
Vanishree Shriraam, Shriraam Mahadevan, M Anitharani, Nalini Sirala Jagadeesh, Sreelekha Bhaskara Kurup, T A Vidya, Krishna G Seshadri
INTRODUCTION: Hypoglycemia tops the list of hurdles in preventing tight glycemic control in diabetic patients. It is even considered as a cardiovascular risk factor. However, it continues to be a neglected complication with very limited epidemiological data in our country. AIM: To study the self-reported prevalence of hypoglycemia among type 2 diabetic patients and the practices adopted by them during and after the episodes to manage and avert future occurrences...
January 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28214690/safety-and-efficacy-of-a-polyherbal-formulation-for-the-management-of-dyslipidemia-and-hyperglycemia-in-patients-with-advanced-stage-of-type-2-diabetes
#12
Mahdi Zarvandi, Hassan Rakhshandeh, Mohammad Abazari, Reza Shafiee-Nick, Ahmad Ghorbani
The present clinical trial was designed to evaluate the safety and efficacy of a polyherbal formulation (PHF) consisted of Allium sativum, Aloe vera, Nigella sativa, Plantago psyllium, Silybum marianum and Trigonella foenum-graecum for controlling dyslipidemia and hyperglycemia in patients with advanced-stage of type-2 diabetes. An open-label phase I trial was carried out on 30 patients who had hyperlipidemia and hyperglycemia before the beginning of the trial in spite of receiving statins and oral hypoglycemic drugs...
February 16, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28214507/impact-of-diabetes-mellitus-on-long-term-mortality-in-patients-presenting-for-coronary-angiography
#13
Barak Zafrir, Ronen Jaffe, Ronen Rubinshtein, Basheer Karkabi, Moshe Y Flugelman, David A Halon
To understand the current impact of diabetes mellitus (DM) on long-term outcomes among patients referred for coronary angiography, we studied 14,337 consecutive patients (5,279 diabetic patients [37%]) referred to coronary angiography for assessment or treatment of coronary artery disease. We investigated long-term all-cause mortality and its interaction with hypoglycemic therapy and presenting coronary status. At baseline, patients with DM had more hypertension, hyperlipidemia, and renal failure; more were women, overweight, and more had previous coronary interventions...
January 25, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28213107/hypoglycemic-effect-of-the-polyphenols-rich-extract-from-rose-rugosa-thunb-on-high-fat-diet-and-stz-induced-diabetic-rats
#14
Liu Liu, Dan Tang, Haiqing Zhao, Xuelei Xin, Haji Akber Aisa
ETHNOPHARMACOLOGICAL RELEVANCE: Rosa rugosa Thunb is traditional Uygur medicine, it is widely used for regulating blood condition, nourishing liver and gallbladder in Uygur ancient prescription. But the mechanism of Rosa rugosa Thunb on diabetes is still unclear. In here, we studied the hypoglycemic effect and explained one probable pathway of polyphenols rich extract from Rosa rugosa Thunb (RPE) on diabetic rats. MATERIALS AND METHODS: In vitro, the effect of RPE on α-glucosidase inhibition was finished, and the antioxidant activity of RPE was evaluated by ABTS and DPPH assay...
February 14, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28207538/comparison-of-baseline-characteristics-and-clinical-course-in-japanese-patients-with-type-2-diabetes-among-whom-different-types-of-oral-hypoglycemic-agents-were-chosen-by-diabetes-specialists-as-initial-monotherapy-jddm-42
#15
Kazuya Fujihara, Risa Igarashi, Satoshi Matsunaga, Yasuhiro Matsubayashi, Takaho Yamada, Hiroki Yokoyama, Shiro Tanaka, Hitoshi Shimano, Hiroshi Maegawa, Katsuya Yamazaki, Koichi Kawai, Hirohito Sone
Little is known about the relationships between patient factors and the antihyperglycemic agents that have been prescribed as initial therapy by diabetes specialists for patients with type 2 diabetes. Moreover, there has been little clarification of the subsequent usage patterns and related factors that influenced the continuation or discontinuation of the drug or the addition of another drug. To provide information on these issues, we evaluated the clinical characteristics of Japanese patients with type 2 diabetes for whom different types of oral hypoglycemic agents (i...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28197897/middle-segment-preserving-pancreatectomy-for-metachronous-intraductal-papillary-mucinous-neoplasm-after-pancreatoduodenectomy-a-case-report
#16
Mihoko Yamada, Teiichi Sugiura, Yukiyasu Okamura, Takaaki Ito, Yusuke Yamamoto, Ryo Ashida, Katsuhiko Uesaka
Total pancreatectomy has occasionally been performed to treat patients with multiple lesions (such as intraductal papillary mucinous neoplasm (IPMN)) or patients who have undergone repeated pancreatic resection. However, deficiencies of the exocrine and endocrine functions worsen patients' quality of life. Recently, there have been several case reports citing middle segment-preserving pancreatectomy (MSPP) as a safe procedure and beneficial with respect to preservation of the exocrine and endocrine functions...
December 2017: Surgical Case Reports
https://www.readbyqxmd.com/read/28196649/diabetes-control-and-the-risks-of-esrd-and-mortality-in%C3%A2-patients%C3%A2-with-ckd
#17
Sankar D Navaneethan, Jesse D Schold, Stacey E Jolly, Susana Arrigain, Wolfgang C Winkelmayer, Joseph V Nally
BACKGROUND: Diabetes is the leading cause of end-stage renal disease (ESRD) and a significant contributor to mortality in the general population. We examined the associations of hemoglobin A1c (HbA1c) levels with ESRD and death in a population with diabetes and chronic kidney disease (CKD). STUDY DESIGN: Cohort study. SETTING & PARTICIPANTS: 6,165 patients with diabetes (treated with oral hypoglycemic agents and/or insulin) and CKD stages 1 to 5 at a large health care system...
February 10, 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/28193094/protective-effects-of-ficus-carica-leaves-on-glucose-and-lipids-levels-carbohydrate-metabolism-enzymes-and-%C3%AE-cells-in-type-2-diabetic-rats
#18
Santiagu Stephen Irudayaraj, Sunil Christudas, Stalin Antony, Veeramuthu Duraipandiyan, Al-Dhabi Naif Abdullah, Savarimuthu Ignacimuthu
CONTEXT: The decoctions of Ficus carica Linn. (Moraceae) leaves are used in the folklore treatment of diabetes. OBJECTIVE: To evaluate the effect of F. carica on glucose and lipids levels, carbohydrate metabolism enzymes and β-cells protective effects in type 2 diabetes. MATERIAL AND METHODS: Diabetes was induced in 15 days high-fat diet (HFD)-fed Wistar rats by intraperitoneal injection of streptozotocin (STZ) (40 mg/kg). The ethyl acetate extract (250 and 500 mg/kg) of F...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28178698/dipeptidyl-peptidase-4-inhibitors-in-chronic-kidney-disease-a-systematic-review-of-randomized-clinical-trials
#19
Simon R Walker, Paul Komenda, Suhail Khojah, Wafa Al-Tuwaijri, Kerry MacDonald, Brett Hiebert, Neil Tangri, Stewart W D Nadurak, Thomas W Ferguson, Claudio Rigatto, Navdeep Tangri
BACKGROUND: Chronic kidney disease (CKD) is common in patients with type 2 diabetes mellitus (T2DM) and limits therapeutic options. Dipeptidyl peptidase-4 (DPP-4) inhibitors represent a novel class of oral glucose-lowering agents and are known to be safe and effective in the general population. METHODS: We searched Cochrane, EMBASE, and PubMed from the time of their inception until March 2015. We included randomized controlled trials analyzing the efficacy (change in hemoglobin A1C [HbA1C]) and safety of DPP-4 agents in individuals with reduced kidney function (estimated glomerular filtration rate <60 mL/min/1...
February 9, 2017: Nephron
https://www.readbyqxmd.com/read/28178625/vaccinium-virgatum-fruit-extract-as-an-important-adjuvant-in-biochemical-and-behavioral-alterations-observed-in-animal-model-of-metabolic-syndrome
#20
Pathise Souto Oliveira, Marta Gazal, Natália Porto Flores, Aline Rigon Zimmer, Vitor Clasen Chaves, Flávio Henrique Reginatto, Manuella Pinto Kaster, Rejane Giacomelli Tavares, Roselia Maria Spanevello, Claiton Leoneti Lencina, Francieli Moro Stefanello
The aim of this study was to investigate the effect of blueberry (Vaccinium virgatum) fruit extract on metabolic, behavioral and oxidative stress parameters in the hippocampus and cerebral cortex of mice submitted to an experimental model of metabolic syndrome induced by a highly palatable diet (HPD). Mice C57BL/6 were divided into 4 experimental groups: (1) received standard chow and saline orally, (2) received standard chow and blueberry hydroalcoholic extract, (3) received HPD and saline orally, (4) received HPD and blueberry hydroalcoholic extract...
February 5, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
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