keyword
MENU ▼
Read by QxMD icon Read
search

Oral hypoglycemic

keyword
https://www.readbyqxmd.com/read/29767261/inhibition-of-mek-erk-stat3-signaling-in-oleuropein-treatment-inhibits-myocardial-ischemia-reperfusion
#1
Hong-Xu Jin, Yun-Hu Zhang, Ruo-Nan Guo, Su-Nuan Zhao
Studies have shown that oleuropein has antifungal, anti‑inflammatory, antiviral, antioxidant, anticancer and hypoglycemic functions. TTC solution staining was used to measure myocardial infarction size. A commercial kit was used to measure lactate dehydrogenase (LDH), creatinine kinase‑MB (CK‑MB), tumor necrosis factor‑α (TNF‑α), interleukin‑1β (IL‑1β), IL 6, superoxide dismutase (SOD), glutathione (GSH), malondialdehyde (MDA) and catalase levels. Western blot analysis was used to measure p53, p-MEK p-ERK and p‑IκBα protein expression...
May 11, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29747745/the-potential-effect-of-garlic-extract-and-curcumin-nanoparticles-against-complication-accompanied-with-experimentally-induced-diabetes-in-rats
#2
Afaf D Abdel-Mageid, Mohamed E S Abou-Salem, Nancy M H A Salaam, Hoda A S El-Garhy
BACKGROUND: Modified herbal medicines implicate the combination of several therapeutic practices of native systems of medicine that may extend many earlier generations, which frequently afford valuable therapeutic benefits. PURPOSE: In this study, the role of nano-curcumin and aged garlic extract (AGE) as two modified phytomedicines on alleviating both of advanced glycation end products (AGEPs) and oxidative stress (OS) in streptozotocin (STZ) induced diabetic rats were investigated during this study...
April 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29745916/fournier-s-gangrene-a-rare-complication-of-diabetes-mellitus-case-report
#3
Sh Muharremi
The presented case reports on 54-years old patient with T2 Diabetes mellitus who, due to hypoglycemic episodes on Insulin therapy, was treated with oral anti-hyperglycemic medications. Patient was on hemodialysis due to the stage 5 chronic kidney failure and had various comorbid conditions: arterial hypertension, history of acute myocardial infarction, dilative cardiomyopathy, amaurosis and peripheral neuropathy. Besides his complicated medical history, patient developed an early stage of Fournier's gangrene...
April 2018: Georgian Medical News
https://www.readbyqxmd.com/read/29744822/study-protocol-for-the-initial-choice-of-dpp-4-inhibitor-in-japanese-patients-with-type-2-diabetes-mellitus-effect-of-linagliptin-on-qol-intel-qol-trial
#4
Tomoya Mita, Toru Hiyoshi, Hidenori Yoshii, Hiroko Chimori, Kazuo Ikeda, Junko Sato, Hirotaka Watada
INTRODUCTION: Consideration of treatment-related quality of life (QOL) is important in diabetes management. However, no studies have compared the influence of dipeptidyl peptidase-4 inhibitors versus metformin on treatment-related QOL when used as first-line therapy in patients with type 2 diabetes mellitus. METHODS: This study is a prospective, randomized, open-label, multicenter, parallel-group, comparative study. Between June 2016 and December 2017, 44 participants who failed to achieve glycemic control despite diet and exercise therapy were recruited at 14 clinics and randomly allocated to linagliptin or metformin therapy...
May 9, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/29737263/glucose-lowering-activity-of-the-aqueous-extract-of-warionia-saharae-in-normal-and-diabetic-rats
#5
Mohamed Eddouks, Morad Hebi
The current study was carried out to investigate the effect of a single dose and daily oral administration for 15 days of the aerial part aqueous extract (A.P.A.E) of Warionia saharae (W. saharae) at a dose of 5 mg/kg body weight on blood glucose levels and the histopathological changes in liver and pancreas both in normal and streptozotocin-induced diabetic rats (STZ). Also, the effect of this extract to improve glucose tolerance in normal rats was demonstrated. Single oral administration of W. saharae A.P...
April 25, 2018: Cardiovascular & Hematological Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/29731444/hypoglycemic-and-hypolipidemic-activities-of-crude-seeds-of-centratherum-anthelminticum-in-healthy-volunteers-and-type-2-diabetic-patients
#6
Hina Akram Mudassir, Shamim Akhter Qureshi, Muhammad Bilal Azmi, Muhammad Ahsan, Musab Kamran, Sakina Jafar
This study first time reports the hypoglycaemic activity of crude seeds powder (CSP) of Centratherum anthelminticum in healthy and type 2 diabetic volunteers. In addition, hypolipidemic effect of same CSP was also determined in healthy volunteers. Healthy individuals were divided into control and two test groups T1 and T2 treated with 200 & 400mg of CSP. Similarly, type 2 diabetic patients were also divided into positive control (PC) treated with metformin 600mg and two test groups DT1 (CSP 400mg + metformin 600mg) & DT2 (CSP 400mg)...
May 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29728986/hypoglycemic-effects-of-intestinal-electrical-stimulation-by-enhancing-nutrient-stimulated-secretion-of-glp-1-in-rats
#7
Feng Ye, Yi Liu, Shiying Li, Jiande D Z Chen
PURPOSE: To find out the best location for intestinal electrical stimulation (IES) to decrease hyperglycemia, and mechanisms involving intraluminal nutrients and plasma glucagon-like peptide-1 (GLP-1) MATERIALS AND METHODS: Eight rats had electrodes implanted at the duodenum and ileums for IES. The oral glucose tolerance test (OGTT) was performed with IES and sham-IES and with/without GLP-1 antagonist, exendin. To study the role of intraluminal nutrients, the experiment was repeated using intraperitoneal glucose tolerance test (IPGTT)...
May 4, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29726577/insulin-degrading-enzyme-is-up-regulated-in-pancreatic-_cells-by-insulin-treatment
#8
Cristina M Fernández-Díaz, Luis Escobar-Curbelo, J F López-Acosta, Carmen D Lobatón, Alfredo Moreno, Julián Sanz-Ortega, Germán Perdomo, Irene Cózar-Castellano
Insulin Degrading Enzyme (IDE) is an endopeptidase that degrades insulin and glucagon. Ide gene has been associated with type-2 diabetes mellitus (DM2). However, the physiological role(s) of IDE in glucose homeostasis and its potential therapeutic benefit remain not completely known. To contribute in the understanding of IDE's role in glucose metabolism, we analyzed IDE protein level in pancreatic islets from two hyperinsulinemic mouse models, db/db and high-fat diet (HFD) mice, as well as in human islets from DM2 patients treated with oral hypoglycemic agents (OHAs) or insulin...
May 4, 2018: Histology and Histopathology
https://www.readbyqxmd.com/read/29719376/theoretical-overview-of-clinical-and-pharmacological-aspects-of-the-use-of-etelcalcetide-in-diabetic-patients-undergoing-hemodialysis
#9
REVIEW
Jianzhen Ye, Guangrui Deng, Feng Gao
Etelcalcetide is the first intravenous calcimimetic agent authorized for the treatment of secondary hyperparathyroidism (sHPT) in patients undergoing hemodialysis in Europe, the US, and Japan. The relationship between sHPT and diabetes resides on complex, bidirectional effects and largely unknown homeostatic mechanisms. Although 30% or more patients with end-stage renal disease are diabetics and about the same percentage of those patients suffer from sHPT associated with hemodialysis, no data on the specificities of the use of etelcalcetide in such patients are available yet...
2018: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29718952/women-are-less-likely-than-men-to-achieve-optimal-glycemic-control-after-1-year-of-treatment-a-multi-level-analysis-of-a-korean-primary-care-cohort
#10
Seung-Ah Choe, Joo Yeong Kim, Young Sun Ro, Sung-Il Cho
We investigated differences in the achievement of glycemic control among newly diagnosed type-2 diabetes patients according to gender using a multi-clinic retrospective cohort study. Optimal glycemic control was defined as hemoglobin A1c (HbA1c) of less than 6.5% after 1 year of diabetes management. A generalized linear mixed model, which controlled for the fixed effects of baseline characteristics and prescribed oral hypoglycemic agent (OHA), was used to calculate the probability of achieving the target HbA1c...
2018: PloS One
https://www.readbyqxmd.com/read/29710864/hypoglycemic-effects-in-alloxan-induced-diabetic-rats-of-the-phenolic-extract-from-mongolian-oak-cups-enriched-in-ellagic-acid-kaempferol-and-their-derivatives
#11
Peipei Yin, Yu Wang, Lingguang Yang, Jinling Sui, Yujun Liu
Our previous reports showed that crude extract prepared with 50% ethanol (ethanol crude extract, ECE) from Mongolian oak cups possessed excellent in vitro antioxidant capacities as well as inhibitory activities against α-glucosidase, α-amylase and protein glycation caused by its enrichment in phenolics, including mainly ellagic acid, kaempferol and their derivatives. Nevertheless, few in vivo studies on antidiabetic activities of these phenolics were conducted. The present study investigated hypoglycemic effects with normal and diabetic rats being administrated orally without or with ECE at 200 and 800 mg/kg for 15 days...
April 30, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29710045/antidiabetic-naphthoquinones-and-their-plant-resources-in-thailand
#12
Muhammad Ajmal Shah, James E Keach, Pharkphoom Panichayupakaranant
Diabetes mellitus is the seventh leading cause of death globally. Ninety percent of the diabetic population suffers from type-2 diabetes, which still needs an effective, safe and economical oral hypoglycemic therapy. Plants are rich sources of various therapeutic molecules. More than 400 medicinal plants of interesting phytochemical diversity have been reported for their antidiabetic potential. Naphthoquinones are a group of phytochemicals, which have a wide range of pharmacological potential, including antidiabetic activity...
2018: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29709919/combination-strategy-with-complexation-hydrogels-and-cell-penetrating-peptides-for-oral-delivery-of-insulin
#13
Yu Fukuoka, El-Sayed Khafagy, Takahiro Goto, Noriyasu Kamei, Kozo Takayama, Nicholas A Peppas, Mariko Takeda-Morishita
In previous studies we showed that the complexation hydrogels based in poly(methacrylic acid-g-ethylene glycol) [P(MAA-g-EG)] rapidly release insulin in the intestine owing to their pH-dependent complexation properties; they also exhibit a high insulin-loading efficiency, enzyme-inhibiting properties, and mucoadhesive characteristics. Cell-penetrating peptides (CPPs), such as oligoarginines [hexa-arginine (R6), comprising six arginine residues], have been employed as useful tools for the oral delivery of therapeutic macromolecules...
2018: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29708829/the-impact-of-testosterone-replacement-therapy-on-glycemic-control-vascular-function-and-components-of-the-metabolic-syndrome-in-obese-hypogonadal-men-with-type-2-diabetes
#14
Kristina Groti, Ivan Žuran, Blaž Antonič, Lidija Foršnarič, Marija Pfeifer
OBJECTIVE: This study set out to assess effects of testosterone replacement therapy (TRT) on parameters of metabolic syndrome and vascular function in obese hypogonadal males with type 2 diabetes mellitus (DM2). STUDY DESIGN: Fifty-five obese hypogonadal diabetic males on oral hypoglycemic treatment were enrolled into this one-year, double-blind, randomized, placebo-controlled clinical study. Group T (n = 28) was treated with testosterone undecanoate (1000 mg i...
April 30, 2018: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/29696241/blood-pressure-and-metabolic-effects-of-acetyl-l-carnitine-in-type-2-diabetes-diabasi-randomized-controlled-trial
#15
Aneliya Parvanova, Matias Trillini, Manuel A Podestà, Ilian P Iliev, Carolina Aparicio, Annalisa Perna, Francesco Peraro, Nadia Rubis, Flavio Gaspari, Antonio Cannata, Silvia Ferrari, Antonio C Bossi, Roberto Trevisan, Sreejith Parameswaran, Jonathan S Chávez-Iñiguez, Fahrudin Masnic, Sidy Mohamed Seck, Teerayuth Jiamjariyaporn, Monica Cortinovis, Luca Perico, Kanishka Sharma, Giuseppe Remuzzi, Piero Ruggenenti, David G Warnock
Context: Acetyl-l-carnitine (ALC), a mitochondrial carrier involved in lipid oxidation and glucose metabolism, decreased systolic blood pressure (SBP), and ameliorated insulin sensitivity in hypertensive nondiabetic subjects at high cardiovascular risk. Objective: To assess the effects of ALC on SBP and glycemic and lipid control in patients with hypertension, type 2 diabetes mellitus (T2D), and dyslipidemia on background statin therapy. Design: After 4-week run-in period and stratification according to previous statin therapy, patients were randomized to 6-month, double-blind treatment with ALC or placebo added-on simvastatin...
May 1, 2018: Journal of the Endocrine Society
https://www.readbyqxmd.com/read/29694288/predicting-adherence-to-chronic-disease-medications-in-patients-with-long-term-initial-medication-fills-using-indicators-of-clinical-events-and-health-behaviors
#16
Julie C Lauffenburger, Jessica M Franklin, Alexis A Krumme, William H Shrank, Olga S Matlin, Claire M Spettell, Gregory Brill, Niteesh K Choudhry
BACKGROUND: Efforts at predicting long-term adherence to medications have been focused on patients filling typical month-long supplies of medication. However, prediction remains difficult for patients filling longer initial supplies, a practice that is becoming increasingly common as a method to enhance medication adherence. OBJECTIVES: To (a) extend methods involving short-term filling behaviors and (b) develop novel variables to predict adherence in a cohort of patients receiving longer initial prescriptions...
May 2018: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/29689314/sodium-glucose-cotransporters-inhibitors-in-type-1-diabetes
#17
REVIEW
Sergio Dellepiane, Moufida Ben Nasr, Emma Assi, Vera Usuelli, Teresa Letizia, Francesca D'Addio, Gian Vincenzo Zuccotti, Paolo Fiorina
Sodium glucose cotransporter inhibitors (SGLTi) are oral hypoglycemic drugs that reduce renal glucose re-uptake and induce glycosuria. SGLTi have been successfully tested in large randomized clinical trials for type 2 diabetes, and several molecules have been approved in this setting by the international pharmaceutical agencies. Additionally, recent evidence has shown that SGLTi may be useful also in type 1 diabetes (T1D). Indeed, these drugs can be used as an ancillary to insulin to improve glycemic control and reduce insulin dosage, and such regimens have been associated with a lower rate of hypoglycemic episodes...
April 21, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29689252/bioadhesive-chitosan-coated-cationic-nanoliposomes-with-improved-insulin-encapsulation-and-prolonged-oral-hypoglycemic-effect-in-diabetic-mice
#18
Thanaa I Shalaby, Wessam M El-Refaie
Oral administration of insulin is hampered by the lack of carriers that can efficiently achieve high encapsulation, avoid gastric degradation, overcome mucosal barriers, and prolong the hypoglycemic effect. Chitosan (CS)-coated insulin-loaded cationic liposomes have been developed and optimized for improved oral delivery. Liposomes were prepared cationic to improve insulin encapsulation. CS was selected as a mucoadhesive coat to prolong system's residence and absorption. The performance of CS-coated compared to uncoated liposomes was examined in-vitro, ex-vivo, and in-vivo in Streptozotocin-induced diabetic mice...
April 21, 2018: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29677194/combined-intervention-of-swimming-plus-metformin-ameliorates-the-insulin-resistance-and-impaired-lipid-metabolism-in-murine-gestational-diabetes-mellitus
#19
Liping Huang, Pingping Yue, Xuefei Wu, Ting Yu, Yang Wang, Ji Zhou, Derun Kong, Keyang Chen
Gestational diabetes mellitus (GDM) has short- and long- term influence on pregnant women and fetus. Swimming, as an aerobic exercise, can effectively improve the blood glucose level in GDM, but the effect of mild swimming alone was not very substantial. Metformin, as an oral antidiabetic drug, has obvious hypoglycemic effect, and is economic also, but the long-term effect on pregnant women and fetus has not been completely clear. We hypothesize that combined intervention of mild swimming and low dose of metformin, may effectively reduce blood glucose, improve the pregnancy outcomes in GDM dams, but simultaneously avoiding the adverse effects caused by overdose of drug and impotence of mild swimming...
2018: PloS One
https://www.readbyqxmd.com/read/29674278/cassia-grandis-fruit-extract-reduces-the-blood-glucose-level-in-alloxan-induced-diabetic-rats
#20
Ariadna Lafourcade Prada, Jesús Rafael Rodríguez Amado, Hady Keita, Edgar Puente Zapata, Helison Carvalho, Emersom Silva Lima, Tatiane Pereira de Sousa, José Carlos Tavares Carvalho
INTRODUCTION: Cassia grandis Lf fruits are ethnobotanically used for digestive disorders, anemia, and for reducing blood glucose. However, there are no studies about the antidiabetic activity nor the oral toxicity of the plant fruit-extracts. This paper aims to evaluate the hypoglycemic effect of C. grandis fruits extract in vivo, and assess the acute oral toxicity, and sub-acute oral toxicity. The antioxidant activity and the α-glycosidase inhibitor effect were also evaluated. METHODS: The extract was obtained by maceration of the fruit pulp with 70% hydroalcoholic solution (1:2, m:v)...
April 16, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
keyword
keyword
84171
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"