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IBS with Constipation

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https://www.readbyqxmd.com/read/28216670/intraluminal-pressure-patterns-in-the-human-colon-assessed-by-high-resolution-manometry
#1
Ji-Hong Chen, Yuanjie Yu, Zixian Yang, Wen-Zhen Yu, Wu Lan Chen, Hui Yu, Marie Jeong-Min Kim, Min Huang, Shiyun Tan, Hesheng Luo, Jianfeng Chen, Jiande D Z Chen, Jan D Huizinga
Assessment of colonic motor dysfunction is rarely done because of inadequate methodology and lack of knowledge about normal motor patterns. Here we report on elucidation of intraluminal pressure patterns using High Resolution Colonic Manometry during a baseline period and in response to a meal, in 15 patients with constipation, chronically dependent on laxatives, 5 healthy volunteers and 9 patients with minor, transient, IBS-like symptoms but no sign of constipation. Simultaneous pressure waves (SPWs) were the most prominent propulsive motor pattern, associated with gas expulsion and anal sphincter relaxation, inferred to be associated with fast propagating contractions...
February 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28215540/decreased-glucagon-like-peptide-1-correlates-with-abdominal-pain-in-patients-with-constipation-predominant-irritable-bowel-syndrome
#2
Zheng-Yang Li, Na Zhang, Shuang Wen, Jing Zhang, Xiu-Li Sun, Xiao-Ming Fan, Yong-Hong Sun
BACKGROUND AND OBJECTIVE: The glucagon-like peptide-1 (GLP-1) analog, ROSE-010, plays a critical role in alleviating abdominal pain in patients with irritable bowel syndrome (IBS); however, the underling mechanism is unclear. In the present study, we determined the serum GLP-1 level in patients with constipation-predominant IBS (IBS-C). The relationship between GLP-1 and abdominal pain was investigated. In addition, the expression of the GLP-1 receptor in the colon was determined. METHODS: Rectosigmoid biopsies were gathered from 38 patients with IBS-C who met the Rome III criteria, and 22 healthy controls...
February 16, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28205278/optimal-dose-of-ramosetron-in-female-patients-with-irritable%C3%A2-bowel-syndrome-with-diarrhea-a-randomized-placebo-controlled-phase-ii-study
#3
S Fukudo, K Matsueda, K Haruma, M Ida, H Hayase, H Akiho, Y Nakashima, M Hongo
BACKGROUND: Previous studies showed that 5 μg of ramosetron, a serotonin (5-hydroxytryptamine: 5-HT)-3 receptor antagonist, is only effective in male patients with irritable bowel syndrome (IBS) with diarrhea (IBS-D). We hypothesized that either dose 1.25, 2.5, or 5 μg of ramosetron would be effective in female patients with IBS-D. METHODS: This randomized, double-blind, placebo-controlled, phase II dose-finding exploratory trial included 409 female outpatients with IBS-D treated in Japan...
February 16, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/28192648/mapping-of-brain-activations-to-rectal-balloon-distension-stimuli-in-male-patients-with-irritable-bowel-syndrome-using-functional-magnetic-resonance-imaging
#4
Anupam Guleria, Arun Karyampudi, Rajan Singh, Chunni L Khetrapal, Abhai Verma, Uday C Ghoshal, Dinesh Kumar
Background/Aims: Irritable bowel syndrome (IBS) is associated with exaggerated cerebral response including emotional processing following visceral stimulation; though data on this issue is available in female IBS patients, it is scanty among male. Hence, we aimed to study brain response of male IBS patients following rectal balloon distension as compared to healthy controls using functional magnetic resonance imaging (fMRI). Data between diarrhea and constipation predominant IBS (IBS-D and IBS-C) were also compared...
February 14, 2017: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/28185025/constipation-pathophysiology-and-current-therapeutic-approaches
#5
Amol Sharma, Satish Rao
Chronic constipation is a common, persistent condition affecting many patients worldwide, presenting significant economic burden and resulting in substantial healthcare utilization. In addition to infrequent bowel movements, the definition of constipation includes excessive straining, a sense of incomplete evacuation, failed or lengthy attempts to defecate, use of digital manoeuvres for evacuation of stool, abdominal bloating, and hard consistency of stools. After excluding secondary causes of constipation, chronic idiopathic or primary constipation can be classified as functional defecation disorder, slow-transit constipation (STC), and constipation-predominant irritable bowel syndrome (IBS-C)...
February 10, 2017: Handbook of Experimental Pharmacology
https://www.readbyqxmd.com/read/28177172/a-single-center-prospective-double-blind-sham-controlled-randomized-study-of-the-effect-of-a-vibrating-capsule-on-colonic-transit-in-patients-with-chronic-constipation
#6
A D Nelson, M Camilleri, A Acosta, A Boldingh, I Busciglio, D Burton, M Ryks, A R Zinsmeister
BACKGROUND: In an open-label study of 26 patients with IBS-C and chronic constipation, treatment with a vibrating (VIBRANT) capsule twice a week for 7.5 weeks resulted in 88.5% responders. Effects on colonic transit are unclear. We aimed to compare effects of VIBRANT and sham capsule treatment on colonic transit in patients with functional constipation. METHODS: Patients with functional constipation (Rome III criteria) were randomized to VIBRANT or sham capsule treatment for 8 weeks and underwent scintigraphic colonic transit measurements during week 8...
February 8, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/28176047/gastrointestinal-physiology-and-function
#7
Beverley Greenwood-Van Meerveld, Anthony C Johnson, David Grundy
The gastrointestinal (GI) system is responsible for the digestion and absorption of ingested food and liquids. Due to the complexity of the GI tract and the substantial volume of material that could be covered under the scope of GI physiology, this chapter briefly reviews the overall function of the GI tract, and discusses the major factors affecting GI physiology and function, including the intestinal microbiota, chronic stress, inflammation, and aging with a focus on the neural regulation of the GI tract and an emphasis on basic brain-gut interactions that serve to modulate the GI tract...
February 8, 2017: Handbook of Experimental Pharmacology
https://www.readbyqxmd.com/read/28160607/overlap-between-irritable-bowel-syndrome-and-functional-dyspepsia-including-subtype-analyses
#8
Yoon Jin Choi, Nayoung Kim, Hyuk Yoon, Cheol Min Shin, Young Soo Park, Jin-Wook Kim, Yong Sung Kim, Dong Ho Lee, Hyun Chae Jung
BACKGROUND AND AIM: Coexistent gastrointestinal symptom profiles and prevalence or associated factors for the overlap between each functional dyspepsia (FD) and irritable bowel syndrome (IBS) group remain unclear. Thus, the aim of the present study was to evaluate the clinicodemographic features of FD, IBS, and IBS-FD overlap and assess the risk factors thereof, including subtype and genetic polymorphisms for IBS-FD. METHODS: Consecutive patients were enrolled from the outpatient Gastroenterology clinics of Bundang Seoul National University Hospitals in Korea...
February 4, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28157108/the-prevalence-of-constipation-and-irritable-bowel-syndrome-in-parkinson-s-disease-patients-according-to-rome-iii-diagnostic-criteria
#9
Takayasu Mishima, Jiro Fukae, Shinsuke Fujioka, Kotoe Inoue, Yoshio Tsuboi
BACKGROUND: Gastrointestinal symptoms are one of the most common non-motor features of Parkinson's disease (PD). Recently, a report from Taiwan revealed that irritable bowel syndrome (IBS) may be associated with an increased risk of developing PD; however, the prevalence of IBS in PD patients has not been fully evaluated. Rome III criteria are widely assessed with a questionnaire to determine functional gastrointestinal disorders. OBJECTIVE: We assessed the prevalence of constipation and IBS in PD patients in our cohort using Rome III criteria...
January 30, 2017: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/28108106/do-children-just-grow-out-of-irritable-bowel-syndrome
#10
Eleonora Giannetti, Marco Maglione, Elisa Sciorio, Vincenzo Coppola, Erasmo Miele, Annamaria Staiano
OBJECTIVE: Few data exist on natural history of irritable bowel syndrome (IBS) in children; therefore we investigated symptoms evolution over time in a cohort of children with IBS. STUDY DESIGN: In this observational, single-center study, we prospectively enrolled newly diagnosed children with IBS and reassessed them after 24 months. At both time points, patients completed a symptoms questionnaire, and a score of stool consistency was obtained. The therapeutic strategy adopted was also recorded...
January 18, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28104985/high-risk-of-temporomandibular-disorder-in-irritable-bowel-syndrome-is-there-a-correlation-with-greater-illness-severity
#11
Serena Gallotta, Vincenzo Bruno, Santo Catapano, Nicola Mobilio, Carolina Ciacci, Paola Iovino
AIM: To investigate the prevalence and the risk of temporomandibular disorders (TMDs) in patients with irritable bowel syndrome (IBS) (including each subtype: constipation, diarrhoea, and mixed) compared to the general population. METHODS: Between January 2014 and December 2015 we enrolled consecutively adult patients diagnosed with IBS at the outpatient clinic of the University of Salerno and healthy controls (HC) without IBS. At enrollment, we analyzed all patients for the presence of TMDs according to the Research Diagnostic Criteria for TMD...
January 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28088179/chronic-constipation-diagnosis-and-treatment-evaluation-the-chro-co-di-t-e-study
#12
Massimo Bellini, Paolo Usai-Satta, Antonio Bove, Renato Bocchini, Francesca Galeazzi, Edda Battaglia, Pietro Alduini, Elisabetta Buscarini, Gabrio Bassotti
BACKGROUND: According to Rome criteria, chronic constipation (CC) includes functional constipation (FC) and irritable bowel syndrome with constipation (IBS-C). Some patients do not meet these criteria (No Rome Constipation, NRC). The aim of the study was is to evaluate the various clinical presentation and management of FC, IBS-C and NRC in Italy. METHODS: During a 2-month period, 52 Italian gastroenterologists recorded clinical data of FC, IBS-C and NRC patients, using Bristol scale, PAC-SYM and PAC-QoL questionnaires...
January 14, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/28066860/is-it-possible-to-distinguish-irritable-bowel-syndrome-with-constipation-from-functional-constipation
#13
M Bouchoucha, G Devroede, C Bon, B Bejou, F Mary, R Benamouzig
BACKGROUND: The Rome III criteria classify patients complaining of constipation into two main groups: patients with functional constipation (FC) and patients with constipation predominant irritable bowel syndrome (IBS-C). The purpose of this study was to identify differences in the intensity of symptoms and total and segmental colonic transit time in these two types of patients. METHODS: We performed a prospective evaluation of 337 outpatients consecutively referred for chronic constipation and classified according to the Rome III criteria as FC or IBS-C...
January 9, 2017: Techniques in Coloproctology
https://www.readbyqxmd.com/read/27982124/the-human-intestinal-microbiota-of-constipated-predominant-irritable-bowel-syndrome-patients-exhibits-anti-inflammatory-properties
#14
Alain P Gobert, Giulia Sagrestani, Eve Delmas, Keith T Wilson, Thomas G Verriere, Michel Dapoigny, Christophe Del'homme, Annick Bernalier-Donadille
The intestinal microbiota of patients with constipated-predominant irritable bowel syndrome (C-IBS) displays chronic dysbiosis. Our aim was to determine whether this microbial imbalance instigates perturbation of the host intestinal mucosal immune response, using a model of human microbiota-associated rats (HMAR) and dextran sulfate sodium (DSS)-induced experimental colitis. The analysis of the microbiota composition revealed a decrease of the relative abundance of Bacteroides, Roseburia-Eubacterium rectale and Bifidobacterium and an increase of Enterobacteriaceae, Desulfovibrio sp...
December 16, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27981684/gastrointestinal-symptom-severity-in-irritable-bowel-syndrome-inflammatory-bowel-disease-and-the-general-population
#15
A D Lee, B M Spiegel, R D Hays, G Y Melmed, R Bolus, D Khanna, P P Khanna, L Chang
BACKGROUND: Irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD) patients report similar gastrointestinal (GI) symptoms, yet comparisons of symptom severity between groups and with the general population (GP) are lacking. METHODS: We compared Patient-Reported Outcomes Measurement Information System (PROMIS(®) ) GI symptom scales measuring gastro-esophageal reflux (GER), disrupted swallowing, diarrhea, bowel incontinence, nausea/vomiting, constipation, belly pain, and gas/bloating in: (i) USA GP sample, (ii) IBS patients, and (iii) IBD patients from tertiary care and community populations...
December 16, 2016: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/27958282/distinct-abnormalities-of-small-bowel-and-regional-colonic-volumes-in-subtypes-of-irritable-bowel-syndrome-revealed-by-mri
#16
Ching Lam, Gemma Chaddock, Luca Marciani Laurea, Carolyn Costigan, Eleanor Cox, Caroline Hoad, Susan Pritchard, Penny Gowland, Robin Spiller
OBJECTIVES: Non-invasive biomarkers which identify different mechanisms of disease in subgroups of irritable bowel syndrome (IBS) could be valuable. Our aim was to seek useful magnetic resonance imaging (MRI) parameters that could distinguish each IBS subtypes. METHODS: 34 healthy volunteers (HV), 30 IBS with diarrhea (IBS-D), 16 IBS with constipation (IBS-C), and 11 IBS with mixed bowel habit (IBS-M) underwent whole-gut transit and small and large bowel volumes assessment with MRI scans from t=0 to t=360 min...
February 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/27922029/safety-of-eluxadoline-in-patients-with-irritable-bowel-syndrome-with-diarrhea
#17
Brooks D Cash, Brian E Lacy, Philip S Schoenfeld, Leonard S Dove, Paul S Covington
OBJECTIVES: Eluxadoline is a mixed μ-opioid receptor (OR) and κ-OR agonist and δ-OR antagonist, approved for the treatment of irritable bowel syndrome with diarrhea (IBS-D). This analysis evaluated the safety and tolerability of eluxadoline 75 and 100 mg twice daily (BID) in one Phase 2 (IBS-2001) and two Phase 3 (IBS-3001 and IBS-3002) studies. METHODS: Adults with IBS-D (Rome III criteria) were randomized to placebo or eluxadoline (75 or 100 mg) BID for 12 (IBS-2001), 26 (IBS-3002), or 52 (IBS-3001) weeks...
February 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/27919824/melatonin-s-role-as-a-co-adjuvant-treatment-in-colonic-diseases-a-review
#18
REVIEW
Eduardo Esteban-Zubero, Laura López-Pingarrón, Moisés Alejandro Alatorre-Jiménez, Purificación Ochoa-Moneo, Celia Buisac-Ramón, Miguel Rivas-Jiménez, Silvia Castán-Ruiz, Ángel Antoñanzas-Lombarte, Dun-Xian Tan, José Joaquín García, Russel J Reiter
Melatonin is produced in the pineal gland as well as many other organs, including the enterochromaffin cells of the digestive mucosa. Melatonin is a powerful antioxidant that resists oxidative stress due to its capacity to directly scavenge reactive species, to modulate the antioxidant defense system by increasing the activities of antioxidant enzymes, and to stimulate the innate immune response through its direct and indirect actions. In addition, the dysregulation of the circadian system is observed to be related with alterations in colonic motility and cell disruptions due to the modifications of clock genes expression...
February 1, 2017: Life Sciences
https://www.readbyqxmd.com/read/27913997/mega-cecum-an-unrecognized-cause-of-symptoms-in-some-female-patients-with-uro-gynecological-symptoms-and-severe-slow-transit-constipation
#19
William Y Chey, Vincent Chang, Cameron M Hoellrich, Kae Yol Lee, Maxine Lubkin, Deborah Corcoran, Ta-Min Chang, William D Chey
BACKGROUND: A subset of female patients with severe constipation report overlapping uro-gynecological symptoms which have been attributed to visceral hypersensitivity. AIMS: To study colon morphology and motor function in female patients with medically refractory chronic constipation with or without uro-gynecological symptoms and to assess clinical outcomes following laparoscopic ileo-proctostomy. METHODS: Colon anatomy and cecal emptying time were assessed with plain films and fluoroscopy following a standardized test meal mixed with barium...
December 2, 2016: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/27898588/the-gut-peptide-neuropeptide-y-and-post-traumatic-stress-disorder
#20
Ann M Rasmusson
PURPOSE OF REVIEW: This article reviews the role of neuropeptide Y (NPY) in the pathophysiology of post-traumatic stress disorder (PTSD) and gastrointestinal disorders such as irritable bowel syndrome (IBS) with which PTSD is highly comorbid. NPY is low in the cerebrospinal fluid and plasma of male combat veterans with PTSD and correlates negatively with sympathetic nervous system (SNS) hyperreactivity, PTSD symptoms and time to recovery. NPY regulation has not yet been evaluated in women with PTSD...
February 2017: Current Opinion in Endocrinology, Diabetes, and Obesity
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