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https://www.readbyqxmd.com/read/29327820/gastroenterology-today-between-certainties-and-news-a-meeting-held-in-turin-on-may-27-2017
#1
Rinaldo Pellicano, Davide G Ribaldone, Marco Astegiano, Luca Dughera, Edda Battaglia, Anna Morgando, Arrigo Arrigoni, Mauro Spandre, Mario Grassini, Giorgio M Saracco, Francis Mégraud
This special article reports on two crucial issues discussed during a meeting. The first was the updated management of Helicobacter pylori infection. This was approached taking into account the recent European Guidelines, with a focus on novelties in treatment. In particular, considering the increasing H. pylori antibiotic resistance to clarithromycin, in countries with a high clarithromycin resistance rate the bismuth-containing quadruple therapies should be preferred. The new formulation, with bismuth, metronidazole, and tetracycline contained in a single capsule (three-in-one), has shown exciting results both in naive and in non-responder patients...
January 10, 2018: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/29319191/linaclotide-in-irritable-bowel-syndrome-with-constipation-a-phase-3-randomized-trial-in-china-and-other-regions
#2
Yunsheng Yang, Jingyuan Fang, Xiaozhong Guo, Ning Dai, Xizhong Shen, Youlin Yang, Jing Sun, Bal Raj Bhandari, David S Reasner, Jacquelyn A Cronin, Mark G Currie, Jeffrey M Johnston, Peter Zeng, Niwat Montreewasuwat, George Zhijian Chen, Sam Lim
BACKGROUND AND AIM: Linaclotide is a guanylate cyclase-C agonist approved in multiple countries to treat irritable bowel syndrome with constipation (IBS-C). China has unmet need for well-tolerated therapy that is effective in treating both bowel and abdominal symptoms of IBS-C. This trial evaluated linaclotide's efficacy and safety in IBS-C patients in China and other regions. METHODS: This Phase 3, double-blind trial randomized IBS-C patients to once-daily oral 290-μg linaclotide or placebo at centers in China, North America, and Oceania...
January 10, 2018: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29316246/sleep-quality-and-functional-gastrointestinal-disorders-a-psychological-issue
#3
Michel Bouchoucha, Florence Mary, Cyriaque Bon, Bakhtiar Bejou, Gheorghe Airinei, Robert Benamouzig
BACKGROUND / AIMS: Sleep disorders are often associated with functional gastro-intestinal disorders (FGIDs). This study aims to evaluate the association of sleep disorders with specific FGIDs and to assess the related importance of psychological disorders. METHODS: We included 1009 consecutive FGID patients (71% female), aged 48.2 ± 16.7 years (M±SD), BMI 26.9 ± 11.2 kg/m2 . These patients filled in a Rome III questionnaire and underwent a psychological evaluation on anxiety and depression...
January 8, 2018: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/29310568/ramosetron-for-the-treatment-of-irritable-bowel-syndrome-with-diarrhea-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#4
Qingqing Qi, Yan Zhang, Feixue Chen, Xiuli Zuo, Yanqing Li
BACKGROUND: Ramosetron is a potent and selective serotonin type 3 receptor antagonist. This meta-analysis aimed to analyze the efficacy and safety of ramosetron for irritable bowel syndrome with diarrhea (IBS-D). METHODS: Pubmed, MEDLINE, EMBASE and the Cochrane Library were searched for randomized controlled trials investigating the efficacy and safety of ramosetron for IBS-D. Risk of bias was assessed as described in the Cochrane handbook. A random effects model was used to calculate the effects of ramosetron vs placebo on symptomatic improvements, including relief of overall IBS symptoms, relief of abdominal discomfort/pain, improvement in abnormal bowel habits, and improvement in stool consistency, expressed as pooled relative risks (RRs) with 95% confidence interval (CI)...
January 8, 2018: BMC Gastroenterology
https://www.readbyqxmd.com/read/29305648/multicenter-observational-study-on-functional-bowel-disorders-diagnosed-using-rome-iii-diagnostic-criteria-in-japan
#5
Masayoshi Ono, Mototsugu Kato, Shuichi Miyamoto, Momoko Tsuda, Takeshi Mizushima, Shouko Ono, Manabu Nakagawa, Katsuhiro Mabe, Soichi Nakagawa, Shuichi Muto, Yuichi Shimizu, Mineo Kudo, Shinichi Katsuki, Takashi Meguro, Naoya Sakamoto
BACKGROUND: The Rome III diagnostic criteria had been used to diagnose functional gastrointestinal disorders (FGIDs) world wide, and functional bowel disorders (FBDs) including irritable bowel syndrome (IBS) have recently attracted the attention of Japanese physicians. However, there have been few reports on the prevalence of FBDs diagnosed by the Rome III diagnostic criteria. AIMS: The aim of this study was to determine the prevalence of FBDs diagnosed according to the diagnostic criteria of Rome III in Japan...
January 5, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29284389/efficacy-and-safety-of-serotonin-receptor-ligands-in-the-treatment-of-irritable-bowel-syndrome-a-review
#6
Agata Binienda, Martin Storr, Jakub Fichna, Maciej Salaga
Irritable bowel syndrome (IBS) is a chronic, recurrent bowel disorder with an unknown etiology, which is most likely multifactorial. Increased mucosal permeability, visceral hypersensitivity and activation status of intestinal mucosal immune cells cause changes in gastrointestinal (GI) motility, secretion and sensation observed in the course of IBS. Permanent, cumbersome symptoms, such as diarrhea, constipation and abdominal pain greatly lower quality of life of IBS patients. On this basis, according to the Rome IV criteria, different forms of IBS can be distinguished...
December 27, 2017: Current Drug Targets
https://www.readbyqxmd.com/read/29278278/determining-an-optimal-dose-of-linaclotide-for-use-in-japanese-patients-with-irritable-bowel-syndrome-with-constipation-a-phase-ii-randomized-double-blind-placebo-controlled-study
#7
S Fukudo, A Nakajima, Y Fujiyama, M Kosako, A Nakagawa, H Akiho, Y Nakashima, J M Johnston, H Miwa
BACKGROUND: Clinical testing to determine a suitable dose of linaclotide for Japanese patients with irritable bowel syndrome with constipation (IBS-C) was needed. METHODS: This was a randomized, double-blind, placebo-controlled, dose-finding trial. Japanese patients with IBS-C diagnosed using Rome III criteria (n = 559, men/women: 49/510) were randomly assigned to 1 of 4 linaclotide doses (0.0625, 0.125, 0.25, or 0.5 mg) or placebo for the 12-week treatment period...
December 26, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/29245334/fatty-acid-components-in-asian-female-patients-with-irritable-bowel-syndrome
#8
Chian Sem Chua, Shih-Yi Huang, Chiao-Wen Cheng, Chyi-Huey Bai, Chien-Yeh Hsu, Hung-Wen Chiu, Jung-Lung Hsu
Abdominal pain is one of the key symptoms of irritable bowel syndrome (IBS). Studies have indicated an increase in the incidence of IBS in Asia. However, yet the pathophysiology of this disease remains unknown. Women are more likely to develop the condition than men, especially the constipation-predominant type. Essential fatty acid (EFA) malnutrition is one of several theories discussing the mechanism of IBS.The authors hypothesized that significant EFA deficiency may cause abdominal pain in patients with IBS...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29184433/diagnosis-and-treatment-of-irritable-bowel-syndrome-with-predominant-constipation-in-the-primary-care-setting-focus-on-linaclotide
#9
REVIEW
Apoorva Krishna Chandar
Irritable bowel syndrome (IBS) is a complex functional gastrointestinal disorder that is exceedingly common in clinical practice. IBS with predominant constipation (IBS-C) is a subtype of IBS that accounts for more than a third of the IBS diagnosed. Diagnosis of IBS requires a careful personalized approach, a comprehensive clinical history, limited but relevant investigations, and continued follow-up. Major IBS societies and guidelines recommend offering a positive diagnosis of IBS based on presenting symptomatology...
2017: International Journal of General Medicine
https://www.readbyqxmd.com/read/29153264/relationship-of-peripheral-blood-neutrophil-to-lymphocyte-ratio-and-irritable-bowel-syndrome
#10
Mustafa Güçlü, A. Faruk Ağan
Background/aim: This study aimed to determine the relationship between the peripheral blood neutrophil to lymphocyte ratio (NLR) and irritable bowel syndrome (IBS). Materials and methods: A total of 107 patients suffering from constipation-predominant IBS, diagnosed in accordance with the ROMA III criteria and having complete blood count tests, were enrolled in this study. All patients underwent total colonoscopy in order to rule out any probable underlying organic colonic pathology. Results: The control group consisted of 106 healthy people with no medical complaints...
August 23, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29152406/protozoan-parasites-in-irritable-bowel-syndrome-a-case-control-study
#11
Khaled A Jadallah, Laila F Nimri, Rola A Ghanem
AIM: To investigate the putative role of protozoan parasites in the development of irritable bowel syndrome (IBS). METHODS: The study included 109 IBS consecutive adult patients fulfilling the Rome III criteria and 100 healthy control subjects. All study subjects filled a structured questionnaire, which covered demographic information and clinical data. Fresh stool samples were collected from patients and control subjects and processed within less than 2 h of collection...
November 6, 2017: World Journal of Gastrointestinal Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29146678/cross-organ-sensitisation-between-the-colon-and-bladder-to-pee-or-not-to-pee
#12
Luke Grundy, Stuart M Brierley
Chronic abdominal and pelvic pain are common, debilitating clinical conditions experienced by millions of patients around the globe. The origin of such pain commonly arises from the intestine and bladder, which share common primary roles; the collection, storage and expulsion of waste. These visceral organs are located in close proximity to one another, and also share common innervation from spinal afferent pathways. Chronic abdominal pain, constipation or diarrhoea are primary symptoms for patients with Irritable Bowel Syndrome (IBS) or Inflammatory Bowel Disease (IBD)...
November 16, 2017: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/29129667/prevalence-of-functional-gastrointestinal-disorders-in-children-and-adolescents-in-the-mediterranean-region-of-europe
#13
Elena Scarpato, Sanja Kolacek, Danijela Jojkic-Pavkov, Vlatka Konjik, Nataša Živković, Enriqueta Roman, Aco Kostovski, Nikolina Zdraveska, Eyad Altamimi, Alexandra Papadopoulou, Thomai Karagiozoglou-Lampoudi, Raanan Shamir, Michal Rozenfeld Bar Lev, Aziz Koleilat, Sirin Mneimneh, Dario Bruzzese, Rosaura Leis, Annamaria Staiano
BACKGROUND & AIMS: Little is known about the prevalence of functional gastrointestinal disorders (FGIDs) in children from the Mediterranean area of Europe. We aimed to assess the prevalence of FGIDs in children and adolescents in this region. METHODS: We collected data on 13,750 children (4-18 years old) enrolled in the Mediterranean-European Area Project, a school-based health study performed in Croatia, Greece, Israel, Italy, Jordan, Lebanon, Macedonia, Serbia, and Spain...
November 9, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29100842/faecal-microbiota-transplantation-versus-placebo-for-moderate-to-severe-irritable-bowel-syndrome-a-double-blind-randomised-placebo-controlled-parallel-group-single-centre-trial
#14
Peter Holger Johnsen, Frank Hilpüsch, Jorunn Pauline Cavanagh, Ingrid Sande Leikanger, Caroline Kolstad, Per Christian Valle, Rasmus Goll
BACKGROUND: Irritable bowel syndrome (IBS) is a common condition characterised by abdominal pain, bloating, and poor quality of life. IBS might be caused by a gut dysbiosis. We aimed to compare faecal microbiota transplantation (FMT) with placebo in patients with IBS. METHODS: In this double-blind, randomised, placebo-controlled, parallel-group, single-centre study, we enrolled patients with IBS with diarrhoea or with diarrhoea and constipation (excluding dominating constipation) defined by the ROME III criteria, scored as moderate to severe according to the IBS severity scoring system (IBS-SSS; a score of ≥175)...
October 31, 2017: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29099770/adenosine-a2b-receptors-an-optional-target-for-the-management-of-irritable-bowel-syndrome-with-diarrhea
#15
REVIEW
Teita Asano, Mitsuko Takenaga
Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder, with the characteristic symptoms of chronic abdominal pain and altered bowel habits (diarrhea, constipation, or both). IBS is a highly prevalent condition, which negatively affects quality of life and is a significant burden on global healthcare costs. Although many pharmacological medicines have been proposed to treat IBS, including those targeting receptors, channels, and chemical mediators related to visceral hypersensitivity, successful pharmacotherapy for the disease has not been established...
November 3, 2017: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/29090081/eluxadoline-in-irritable-bowel-syndrome-with-diarrhea-rationale-evidence-and-place-in-therapy
#16
REVIEW
Kenneth Barshop, Kyle Staller
Irritable bowel syndrome (IBS) is the most common gastrointestinal (GI) disorder worldwide, however treatment options for diarrhea-predominant IBS (IBS-D) remain limited. Eluxadoline, a µ- and κ-opioid receptor agonist and δ-opioid receptor antagonist, was recently approved for the treatment of IBS-D. A novel compound first described in 2008, eluxadoline was shown to normalize GI transit, with a subsequent phase I demonstrating its safety and tolerability in healthy adults. In 2016, two randomized, double-blind, placebo-controlled phase III trials studying eluxadoline use at 75 mg and 100 mg twice daily over 26 weeks demonstrated a significant improvement in stool consistency and many global symptoms of IBS...
November 2017: Therapeutic Advances in Chronic Disease
https://www.readbyqxmd.com/read/29027719/glioplasticity-in-irritable-bowel-syndrome
#17
N L Lilli, L Quénéhervé, S Haddara, C Brochard, P Aubert, M Rolli-Derkinderen, T Durand, P Naveilhan, J-B Hardouin, R De Giorgio, G Barbara, S Bruley des Varannes, E Coron, M Neunlist
BACKGROUND: Growing evidence indicates a wide array of cellular remodeling in the mucosal microenvironment during irritable bowel syndrome (IBS), which possibly contributes to pathophysiology and symptom generation. Here, we investigated whether enteric glial cells (EGC) may be altered, and which factors/mechanisms lead to these changes. METHODS: Colonic mucosal biopsies of IBS patients (13 IBS-Constipation [IBS-C]; 10 IBS-Diarrhea [IBS-D]; 11 IBS-Mixed [IBS-M]) and 24 healthy controls (HC) were analyzed...
October 13, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/29022143/comorbidity-of-gastrointestinal-disorders-migraine-and-tension-type-headache-a-cross-sectional-study-in-iran
#18
Fahimeh Martami, Zeinab Ghorbani, Maryam Abolhasani, Mansoureh Togha, Alipasha Meysamie, Alireza Sharifi, Soodeh Razeghi Jahromi
Migraine can be accompanied by some gastrointestinal (GI) disorders. In this study, we aimed to investigate the relationship between migraine and tension-type headache (TTH) and different lower and upper GI disorders as well as non-alcoholic fatty liver (NAFLD) and cholelithiasis. This cross-sectional study included 1574 overweight and obese participants who were referred to the Obesity Research Center of Sina Hospital, Tehran, Iran. The diagnosis of migraine and TTH was made by an expert neurologist based on the international classification of headache disorders-III β (ICHD III β)...
October 11, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28992677/nationwide-multicenter-study-for-overlaps-of-common-functional-gastrointestinal-disorders-in-korean-patients-with-constipation
#19
Kyung Sik Park, Sam Ryong Jee, Bong Eun Lee, Kyoung Sup Hong, Jeong Eun Shin, Soo-Young Na, Joong Goo Kwon, Suck Chei Choi, Yong Sung Kim, Hyun Seok Lee, Tae Hee Lee, Kyeong Ok Kim, Jongkyoung Choi, Hee Seok Moon, Yeon Soo Kim, Moo In Park, Soo Jung Park, Seon-Young Park, Sung Noh Hong
Background/Aims: In spite of increased concerns about the overlaps among the various functional gastrointestinal disorders (FGIDs), studies for the overlap between constipation and other common FGIDs are rare. Therefore, we investigated the patterns of overlaps between constipation and other common FGIDs. Methods: This study was designed as a prospective nationwide multi-center questionnaire study using Rome III questionnaires for functional dyspepsia (FD), irritable bowel syndrome (IBS), and functional constipation (FC), as well as various questionnaires about patients' information, degree of symptoms, and quality of life...
October 30, 2017: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/28989282/spotlight-on-eluxadoline-for-the-treatment-of-patients-with-irritable-bowel-syndrome-with-diarrhea
#20
REVIEW
Konstantinos C Fragkos
BACKGROUND: Irritable bowel syndrome with diarrhea (IBS-D) has limited options for treatment currently, including mainly anti-motility medications, antispasmodics, and antidepressants. This review discusses the properties of a new drug, eluxadoline, a gut-targeting mu- and kappa-opioid receptor agonist and a delta-opioid receptor antagonist, and its efficacy and safety in patients with IBS-D. MATERIALS AND METHODS: A systematic review of the literature was undertaken to identify studies that had investigated eluxadoline as a treatment in IBS-D...
2017: Clinical and Experimental Gastroenterology
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