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IBS with Constipation

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https://www.readbyqxmd.com/read/27913997/mega-cecum-an-unrecognized-cause-of-symptoms-in-some-female-patients-with-uro-gynecological-symptoms-and-severe-slow-transit-constipation
#1
William Y Chey, Vincent Chang, Cameron M Hoellrich, Kae Yol Lee, Maxine Lubkin, Deborah Corcoran, Ta-Min Chang, William D Chey
BACKGROUND: A subset of female patients with severe constipation report overlapping uro-gynecological symptoms which have been attributed to visceral hypersensitivity. AIMS: To study colon morphology and motor function in female patients with medically refractory chronic constipation with or without uro-gynecological symptoms and to assess clinical outcomes following laparoscopic ileo-proctostomy. METHODS: Colon anatomy and cecal emptying time were assessed with plain films and fluoroscopy following a standardized test meal mixed with barium...
December 2, 2016: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/27898588/the-gut-peptide-neuropeptide-y-and-post-traumatic-stress-disorder
#2
Ann M Rasmusson
PURPOSE OF REVIEW: This article reviews the role of neuropeptide Y (NPY) in the pathophysiology of post-traumatic stress disorder (PTSD) and gastrointestinal disorders such as irritable bowel syndrome (IBS) with which PTSD is highly comorbid. NPY is low in the cerebrospinal fluid and plasma of male combat veterans with PTSD and correlates negatively with sympathetic nervous system (SNS) hyperreactivity, PTSD symptoms and time to recovery. NPY regulation has not yet been evaluated in women with PTSD...
November 24, 2016: Current Opinion in Endocrinology, Diabetes, and Obesity
https://www.readbyqxmd.com/read/27895427/irritable-bowel-syndrome-evaluation-using-computed-tomography-colonography
#3
Hideki Ohgo, Hiroyuki Imaeda, Minoru Yamaoka, Kazuaki Yoneno, Naoki Hosoe, Takeshi Mizukami, Hidetomo Nakamoto
AIM: To evaluate the morphology of the colon in patients with irritable bowel syndrome (IBS) by using computed tomography colonography (CTC). METHODS: Twelve patients with diarrhea type IBS (IBS-D), 13 patients with constipation type IBS (IBS-C), 12 patients with functional constipation (FC) and 14 control patients underwent colonoscopy following CTC. The lengths of the rectosigmoid colon, transverse colon and the total colon were measured. The diameters of the rectum, sigmoid colon, descending colon, transverse colon, and ascending colon were measured...
November 14, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27875419/new-treatment-options-for-irritable-bowel-syndrome-with-predominant-diarrhea
#4
H Christian Weber
PURPOSE OF REVIEW: Irritable bowel syndrome (IBS) is a highly prevalent gastrointestinal disorder with negative impact on quality of life and it represents a substantial economic burden on healthcare cost. The medical management of IBS remains largely symptomatic. This review provides an update related to the most recently published diagnostic Rome IV criteria for IBS and clinical trial data for novel treatment modalities in IBS targeting the peripheral opioid receptors of the enteric nervous system and the gut microbiota...
November 24, 2016: Current Opinion in Endocrinology, Diabetes, and Obesity
https://www.readbyqxmd.com/read/27822226/somatic-comorbidity-in-chronic-constipation-more-data-from-the-gecco-study
#5
Paul Enck, Johannes Leinert, Menno Smid, Thorsten Köhler, Juliane Schwille-Kiuntke
Background. Comorbidity in chronic constipation has rarely been investigated, despite the fact that constipation can occur as one symptom in a number of neurological, systemic, and other nonintestinal and intestinal disorders. Methods. Of 1037 individuals with constipation identified during a telephone survey, 589 returned a postal questionnaire with valid data, asking for sociographic data, clinical symptoms, comorbid conditions, medication intake, and health care behavior related to constipation. Among them, 245 reported some somatic diagnoses and another 120 regular medication intake...
2016: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/27815079/efficacy-and-safety-of-enteric-coated-capsules-of-anise-oil-to-treat-irritable-bowel-syndrome
#6
Maryam Mosaffa-Jahromi, Kamran Bagheri Lankarani, Mehdi Pasalar, Suleiman Afsharypuor, Ali-Mohammad Tamaddon
ETHNOPHARMACOLOGICAL RELEVANCE: Anise is a well-recognized plant in Traditional Persian Medicine (TPM) sources. Anise oil has been suggested for the treatment of bowel disorders in Persian medical textbooks. Based on TPM scholars, this ingredient has a favorable effect on gastrointestinal diseases. We did this trial to determine the efficacy and safety of enteric coated capsules of anise oil for clinical symptoms of irritable bowel syndrome (IBS). METHODS AND MATERIALS: This three-armed double-blind clinical trial was carried out from August 2014 to February 2015...
November 1, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27800536/gastrointestinal-headache-a-narrative-review
#7
REVIEW
Majid T Noghani, Hossein Rezaeizadeh, Sayed Mohammad Baqer Fazljoo, Mansoor Keshavarz
There are studies reporting primary headaches to be associated with gastrointestinal disorders, and some report resolution of headache following the treatment of the associated gastrointestinal disorder. Headache disorders are classified by The International Headache Society as primary or secondary; however, among the secondary headaches, those attributed to gastrointestinal disorders are not appreciated. Therefore, we aimed to review the literature to provide evidence for headaches, which originate from the gastrointestinal system...
November 2016: Emergency (Tehran, Iran)
https://www.readbyqxmd.com/read/27784966/association-between-gastrointestinal-symptoms-and-affectivity-in-patients-with-bipolar-disorder
#8
Pontus Karling, Martin Maripuu, Mikael Wikgren, Rolf Adolfsson, Karl-Fredrik Norrback
AIM: To study if anxiety, depression and experience of stress are associated with gastrointestinal (GI) symptoms in patients with bipolar disorder. METHODS: A total of 136 patients with bipolar disorder (mean age 49.9 years; 61% women) and 136 controls from the general population (mean age 51.0 years; 60% women) were included in the study. GI symptoms were assessed with The Gastrointestinal Symptom Rating Scale-irritable bowel syndrome (GSRS-IBS), level of anxiety and depression with The Hospital Anxiety and Depression Scale (HADS) and stress-proneness with Perceived Stress Questionnaire...
October 14, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27783533/a-case-control-comparison-of-direct-healthcare-provider-medical-costs-of-chronic-idiopathic-constipation-and-irritable-bowel-syndrome-with-constipation-in-a-community-based-cohort
#9
Linda M Herrick, William M Spalding, Yuri A Saito, James Moriarty, Cathy Schleck
OBJECTIVE: Patients with constipation account for 3.1 million United States physician visits a year, but care costs for patients with irritable bowel syndrome with constipation (IBS-C) or chronic idiopathic constipation (CIC) compared to the general public have received little study. The study aim was to describe healthcare utilization and compare medical costs for patients with IBS-C or CIC versus matched controls from a community-based sample. METHODS: A nested case-control sample (IBS-C and CIC cases) and matched controls (1:2) for each case group were selected from Olmsted County, MN individuals responding to a community-based survey of gastrointestinal symptoms (2008) who received healthcare from a participating Rochester Epidemiology Project (REP) provider...
October 26, 2016: Journal of Medical Economics
https://www.readbyqxmd.com/read/27782892/efficacy-of-synbiotic-probiotic-and-prebiotic-treatments-for-irritable-bowel-syndrome-in-children-a-randomized-controlled-trial
#10
Ahmet Baştürk, Reha Artan, Aygen Yılmaz
BACKGROUND/AIMS: Irritable bowel syndrome (IBS) is an important health problem that presents serious social burdens and high costs. Our study investigated the efficacy of synbiotic (Bifidobacterium lactis B94 with inulin), probiotic (B. lactis B94), and prebiotic (inulin) treatment for IBS in a pediatric age group. MATERIAL AND METHODS: This study was randomized, double-blind, controlled, and prospective in design and included 71 children between the ages of 4 and 16 years who were diagnosed with IBS according to the Rome III criteria...
September 2016: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/27757180/herbal-medicines-for-the-management-of-irritable-bowel-syndrome-a-systematic-review
#11
Hamid Reza Bahrami, Shokouhsadat Hamedi, Roshanak Salari, Mohammadreza Noras
Irritable Bowel Syndrome (IBS) is a chronic digestive disorder, which is characterized by abdominal pain, bloating, diarrhea and constipation periods. The etiology is unknown. Based on the different mechanisms in the etiology, treatment focuses on controlling symptoms. Due to the longtime of syndrome, inadequacy of current treatments, financial burden for patients and pharmacologic effects, several patients have turned to the use of complementary and alternative medicine (CAM). Complementary and alternative treatments for IBS include hypnosis, acupuncture, cognitive behavior therapy, yoga, and herbal medicine...
August 2016: Electronic Physician
https://www.readbyqxmd.com/read/27756121/associations-between-excessive-daytime-sleepiness-and-functional-gastrointestinal-disorders-a-population-based-study-in-china
#12
Sicheng Wu, Shuqi Chen, Yanfang Zhao, Xiuqiang Ma, Rui Wang, Jia He
Background/Aims: Several studies have demonstrated that sleep problems are associated with functional gastrointestinal disorders (FGIDs), such as irritable bowel syndrome (IBS), and functional dyspepsia etc, but the relationship between excessive daytime sleepiness (EDS) and FGIDs has not been systematically studied in general population. This study aimed to explore the relationship between EDS and specific types of FGIDs and the effect of the number of FGIDs on EDS. Methods: A sample of 3600 individuals (aged 18-80 years) was selected from 5 regions in China using a randomized stratified multi-stage sampling method...
October 17, 2016: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/27743332/gastrointestinal-symptoms-predictors-of-health-related-quality-of-life-in-pediatric-patients-with-functional-gastrointestinal-disorders
#13
James W Varni, Robert J Shulman, Mariella M Self, Samuel Nurko, Miguel Saps, Shehzad A Saeed, Ashish S Patel, Chelsea Vaughan Dark, Cristiane B Bendo, John F Pohl
OBJECTIVES: To investigate the patient-reported multidimensional gastrointestinal symptoms predictors of generic health-related quality of life (HRQOL) in pediatric patients with functional gastrointestinal disorders (FGIDs). METHODS: The Pediatric Quality of Life Inventory™ (PedsQL™) Gastrointestinal Symptoms Scales and PedsQL™ 4.0 Generic Core Scales were completed in a 9-site study by 259 pediatric patients with functional constipation, functional abdominal pain (FAP), or irritable bowel syndrome (IBS)...
October 14, 2016: Quality of Life Research
https://www.readbyqxmd.com/read/27738447/comparison-of-electroacupuncture-and-moxibustion-for-relieving-visceral-hypersensitivity-in-rats-with-constipation-predominant-irritable-bowel-syndrome
#14
Ji-Meng Zhao, Liu Chen, Ci-Li Zhou, Yin Shi, Yu-Wei Li, Hai-Xia Shang, Lu-Yi Wu, Chun-Hui Bao, Chuan-Zi Dou, Huan-Gan Wu
Aim. To compare whether there is different effect between electroacupuncture (EA) and moxibustion (Mox) on visceral hypersensitivity (their analgesic effects) in constipation-predominant irritable bowel syndrome (C-IBS). Methods. EA at 1 mA and 3 mA and Mox at 43°C and 46°C were applied to the Shangjuxu (ST37, bilateral) acupoint in rats with C-IBS and normal rats. An abdominal withdrawal reflex (AWR) score was used to assess visceral hypersensitivity. Toluidine blue staining was used to assess mast cell (MC) activity in colon of rats...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27696378/probiotics-fiber-and-herbal-medicinal-products-for-functional-and-inflammatory-bowel-disorders
#15
Diego Currò, Gianluca Ianiro, Silvia Pecere, Stefano Bibbò, Giovanni Cammarota
Functional bowel disorders (FBDs), mainly irritable bowel syndrome (IBS) and functional constipation (FC, also called chronic idiopathic constipation), are highly diffused worldwide. Inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease, although less common, has a strong impact on patients' quality of life, as well as is highly expensive for our healthcare. A definite cure for those disorders is still yet to come. Over the years, several therapeutic approaches complementary or alternative to traditional pharmacological treatments, including probiotics, prebiotics, synbiotics, fiber and herbal medicinal products, have been investigated for the management of both groups of diseases...
October 3, 2016: British Journal of Pharmacology
https://www.readbyqxmd.com/read/27669680/effects-of-baseline-abdominal-pain-and-bloating-on-response-to-lubiprostone-in-patients-with-irritable-bowel-syndrome-with-constipation
#16
L Chang, W D Chey, D Drossman, T Losch-Beridon, M Wang, P Lichtlen, S Mareya
BACKGROUND: Lubiprostone (8 μg b.d.) received US Food and Drug Administration (FDA) approval in 2008 for the treatment of constipation-predominant irritable bowel syndrome (IBS-C) in women aged ≥18 years. In 2012, the FDA issued new guidance for IBS-C clinical trials, recommending a composite endpoint incorporating both abdominal pain and stool frequency. AIM: In a post hoc analysis, similar criteria were applied to data from two pivotal, phase 3, double-blind, randomised trials of lubiprostone in patients with IBS-C...
November 2016: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/27662586/limited-prolonged-effects-of-rifaximin-treatment-on-irritable-bowel-syndrome-related-differences-in-the-fecal-microbiome-and-metabolome
#17
Natalia Zeber-Lubecka, Maria Kulecka, Filip Ambrozkiewicz, Agnieszka Paziewska, Krzysztof Goryca, Jakub Karczmarski, Tymon Rubel, Wojciech Wojtowicz, Piotr Mlynarz, Lukasz Marczak, Roman Tomecki, Michal Mikula, Jerzy Ostrowski
Irritable bowel syndrome (IBS) is a chronic functional disorder and its development may be linked, directly and indirectly, to intestinal dysbiosis. Here we investigated the interactions between IBS symptoms and the gut microbiome, including the relation to rifaximin (1200 mg daily; 11.2 g per a treatment). We recruited 72 patients, including 31 with IBS-D (diarrhea), 11 with IBS-C (constipation), and 30 with IBS-M (mixed constipation and diarrhea) and 30 healthy controls (HCs). Of them, 68%, 64%, and 53% patients with IBS-D, IBS-C, and IBS-M, respectively, achieved 10-12 week-term improvement after the rifaximin treatment...
September 2, 2016: Gut Microbes
https://www.readbyqxmd.com/read/27636926/-efficacy-of-kolofort-for-the-treatment-of-patients-with-irritable-bowel-syndrome
#18
V V Tsukanov, O S Rzhavicheva, A V Vasyutin, O V Dunaevskaya, Yu L Tonkikh, E P Bronnikova
AIM: to determine the efficacy and safety of Kolofort in the treatment of patients with irritable bowel syndrome (IBS). SUBJECTS AND METHODS: 52 patients (16 men and 36 women) aged 26 to 59 years were examined over 4 months to rule out organic disease. The diagnosis of IBS was established on the basis of the Rome III diagnostic criteria (2006). Seven patients were diagnosed as having IBS with a preponderance of constipation; 3 had IBS with a preponderance of diarrhea, and 42 had mixed IBS...
2016: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/27624325/does-frequency-of-restless-legs-syndrome-and-poor-sleep-quality-increase-with-age-in-irritable-bowel-syndrome
#19
Akif Acay, Ahmet Bal, Serdar Oruc, Taner Ozkececi, Muzaffer Sariaydin, Hayri Demirbas, Gursel Acarturk
BACKGROUND: Irritable bowel syndrome (IBS) is a common gastrointestinal disease which leads to a reduction in the quality of life. Restless legs syndrome (RLS) and the incidence of poor sleep quality (PSQ) are known to increase in IBS. In this study, we aimed to investigate the prevalence and association of RLS and PSQ in a young population. METHODS: A total of 112 IBS patients (46 constipation predominant IBS, 17 diarrhea predominant IBS, 23 mixed IBS and 26 unsubtyped IBS) and 106 healthy controls were included in the study...
September 13, 2016: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/27619727/supernatants-of-irritable-bowel-syndrome-mucosal-biopsies-impair-human-colonic-smooth-muscle-contractility
#20
M P Guarino, G Barbara, A Cicenia, A Altomare, M R Barbaro, S Cocca, A Scirocco, C Cremon, S Emerenziani, V Stanghellini, M Cicala, C Severi
BACKGROUND: Changes in intestinal motility are likely to contribute to irritable bowel syndrome (IBS) pathophysiology. The aim of the study was to investigate the effects of IBS mucosal supernatants on human colonic muscle contractility. METHODS: Supernatants were obtained from biopsies of 18 IBS patients-nine with constipation (IBS-C) and nine with diarrhea-predominant IBS (IBS-D)-and nine asymptomatic subjects, used as controls. Colonic circular smooth muscle strips or isolated cells (SMC) were exposed to control or IBS supernatants...
September 12, 2016: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
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