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https://www.readbyqxmd.com/read/29769307/orally-bioavailable-and-blood-brain-barrier-penetrating-atm-inhibitor-az32-radiosensitizes-intracranial-gliomas-in-mice
#1
Jeremy Karlin, Jasmine Allen, Syed F Ahmad, Gareth Hughes, Victoria Sheridan, Rajesh Odedra, Paul Farrington, Elaine B Cadogan, Lucy C Riches, Antonio Garcia-Trinidad, Andrew G Thomason, Bhavika Patel, Jennifer Vincent, Alan Lau, Kurt G Pike, Thomas A Hunt, Amrita Sule, Nicholas C K Valerie, Laura Biddlestone-Thorpe, Jenna Kahn, Jason M Beckta, Nitai Mukhopadhyay, Bernard Barlaam, Sebastien L Degorce, Jason Kettle, Nicola Colclough, Joanne Wilson, Aaron Smith, Ian P Barrett, Li Zheng, Tianwei Zhang, Yingchun Wang, Kan Chen, Martin Pass, Stephen T Durant, Kristoffer Valerie
Inhibition of ataxia-telangiectasia mutated (ATM) during radiotherapy of glioblastoma multiforme (GBM) may improve tumor control by short-circuiting the response to radiation-induced DNA damage. A major impediment for clinical implementation is that current inhibitors have limited CNS bioavailability, thus, the goal was to identify ATM inhibitors (ATMi) with improved CNS penetration. Drug screens and refinement of lead compounds identified AZ31 and AZ32. The compounds were then tested in vivo for efficacy and impact on tumor and healthy brain...
May 16, 2018: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/29730271/intraventricular-extension-of-an-aneurysmal-subarachnoid-hemorrhage-is-an-independent-predictor-of-a-worse-functional-outcome
#2
Mario Zanaty, Daichi Nakagawa, Robert M Starke, Enrique C Leira, Edgar A Samaniego, Waldo R Guerrero, James Torner, Yasunori Nagahama, Olatilewa Awe, Jeremy Greenlee, Joseph S Hudson, Lauren Allan, Reem Elwy, Nohra Chalouhi, Pascal Jabbour, Royce Woodroffe, Anthony Piscopo, David Hasan
OBJECTIVE: The objective of this study is to determine the impact of intraventricular hemorrhage (IVH) on the cognitive prognosis of subarachnoid hemorrhage (SAH) due to ruptured cerebral aneurysm, independent of the presence of intraparenchymal hemorrhage, hydrocephalus or vasospasm. PATIENT AND METHODS: A Retrospective review of a prospectively collected database of patients with aneurysmal SAH from July 2009 to November 2016 was performed. Patients were included if they had a saccular aneurysm with a Hunt-Hess grade (HHG) 1-3...
April 30, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29566801/transcatheter-pulmonary-valve-replacement-with-the-melody-valve-in-small-diameter-expandable-right-ventricular-outflow-tract-conduits
#3
Shabana Shahanavaz, Athar M Qureshi, Daniel S Levi, Younes Boudjemline, Lynn F Peng, Mary Hunt Martin, Holly Bauser-Heaton, Britton Keeshan, Jeremy D Asnes, Thomas K Jones, Henri Justino, Jamil A Aboulhosn, Robert G Gray, Hoang Nguyen, David T Balzer, Doff B McElhinney
OBJECTIVES: This study sought to evaluate the safety, feasibility, and outcomes of transcatheter pulmonary valve replacement (TPVR) in conduits ≤16 mm in diameter. BACKGROUND: The Melody valve (Medtronic, Minneapolis, Minnesota) is approved for the treatment of dysfunctional right ventricular outflow tract (RVOT) conduits ≥16 mm in diameter at the time of implant. Limited data are available regarding the use of this device in smaller conduits. METHODS: The study retrospectively evaluated patients from 9 centers who underwent percutaneous TPVR into a conduit that was ≤16 mm in diameter at the time of implant, and reported procedural characteristics and outcomes...
March 26, 2018: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29559336/do-people-with-parkinson-s-disease-look-at-task-relevant-stimuli-when-walking-an-exploration-of-eye-movements
#4
David Hunt, Samuel Stuart, Jeremy Nell, Jeffrey M Hausdorff, Brook Galna, Lynn Rochester, Lisa Alcock
Eye movements are impaired by Parkinson's disease (PD) although limited research has explored if PD affects the relevance of visual fixations when walking. Visual fixations may provide crucial contextual information for safe navigation and important insights into fall risk. This study aimed to: investigate visual fixations made while walking under a range of conditions in PD; identify their task relevance; and explore their relationship with clinical features. Thirty-eight people with mild-moderate PD and forty age-matched control participants completed a straight walk with (i) no additional stimuli and (ii) with additional stimuli (visual cues or a high contrast obstacle), whilst wearing a mobile eye-tracker...
March 17, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29498589/lived-experience-of-young-widowed-individuals-a-qualitative-study
#5
Eunicia Jones, Megan Oka, Jeremy Clark, Heather Gardner, Robin Hunt, Spencer Dutson
Young widowhood is a unique experience that has received little in-depth attention in research and clinical settings. The present study examined the lived experiences of young men and women who had lost a spouse. Eleven men and women between the ages of 18 and 49 were interviewed about their experiences postloss using phenomenological methods. After coding the interviews, three themes emerged: (1) relationship prior to death, (2) coping, and (3) concerns. Clinical implications included the need for more accessible resources for young widowed individuals, such as therapeutic services, finances, and childcare...
March 2, 2018: Death Studies
https://www.readbyqxmd.com/read/29409041/the-endocrine-and-metabolic-characteristics-of-a-large-bardet-biedl-syndrome-clinic-population
#6
Safa Mujahid, Katharine F Hunt, Yee S Cheah, Elizabeth Forsythe, Jonathan M Hazlehurst, Kathryn Sparks, Shehla Mohammed, Jeremy W Tomlinson, Stephanie A Amiel, Paul V Carroll, Phillip L Beales, Mohammed S B Huda, Barbara M McGowan
Context: Bardet-Biedl syndrome (BBS) is a rare autosomal recessive disorder in which previous reports have described obesity and a metabolic syndrome. Objective: Describe the endocrine and metabolic characteristics of a large BBS population compared with matched controls. Design: Case-control. Setting: Hospital clinic. Patients: A clinical/genetic diagnosis of BBS. Intervention: None...
February 1, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29362800/preferred-reporting-items-for-a-systematic-review-and-meta-analysis-of-diagnostic-test-accuracy-studies-the-prisma-dta-statement
#7
Matthew D F McInnes, David Moher, Brett D Thombs, Trevor A McGrath, Patrick M Bossuyt, Tammy Clifford, Jérémie F Cohen, Jonathan J Deeks, Constantine Gatsonis, Lotty Hooft, Harriet A Hunt, Christopher J Hyde, Daniël A Korevaar, Mariska M G Leeflang, Petra Macaskill, Johannes B Reitsma, Rachel Rodin, Anne W S Rutjes, Jean-Paul Salameh, Adrienne Stevens, Yemisi Takwoingi, Marcello Tonelli, Laura Weeks, Penny Whiting, Brian H Willis
Importance: Systematic reviews of diagnostic test accuracy synthesize data from primary diagnostic studies that have evaluated the accuracy of 1 or more index tests against a reference standard, provide estimates of test performance, allow comparisons of the accuracy of different tests, and facilitate the identification of sources of variability in test accuracy. Objective: To develop the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) diagnostic test accuracy guideline as a stand-alone extension of the PRISMA statement...
January 23, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29356803/hospitalist-perspective-of-interactions-with-medicine-subspecialty-consult-services
#8
Traci N Adams, Joanna Bonsall, Daniel Hunt, Alberto Puig, Jeremy B Richards, Liyang Yu, Jakob I McSparron, Nainesh Shah, Jonathan Weissler, Eli M Miloslavsky
BACKGROUND: Medicine subspecialty consultation is becoming increasingly important in inpatient medicine. OBJECTIVE: We conducted a survey study in which we examined hospitalist practices and attitudes regarding medicine subspecialty consultation. DESIGN AND SETTING: The survey instrument was developed by the authors based on prior literature and administered online anonymously to hospitalists at 4 academic medical centers in the United States...
November 22, 2017: Journal of Hospital Medicine: An Official Publication of the Society of Hospital Medicine
https://www.readbyqxmd.com/read/29339349/jeremy-hunt-s-new-department-major-overhaul-or-window-dressing
#9
Gareth Iacobucci
No abstract text is available yet for this article.
January 16, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29227712/a-comparison-of-pain-fatigue-dyspnea-and-their-impact-on-quality-of-life-in-pulmonary-rehabilitation-participants-with-chronic-obstructive-pulmonary-disease
#10
Yi-Wen Chen, Pat G Camp, Harvey O Coxson, Jeremy D Road, Jordan A Guenette, Michael A Hunt, W Darlene Reid
In addition to dyspnea and fatigue, pain is a prevalent symptom in chronic obstructive pulmonary disease (COPD). Understanding the relative prevalence, magnitude, and interference with aspects of daily living of these symptoms can improve COPD management. Therefore, the purposes of this study were to: (1) compare the prevalence and magnitude of dyspnea, fatigue, and pain and how each limits aspects of daily living; (2) determine the association between pain and the other two symptoms; and (3) assess the impact of these symptoms on quality of life in COPD...
February 2018: COPD
https://www.readbyqxmd.com/read/29193671/percutaneous-transcatheter-pulmonary-valve-replacement-in-children-weighing-less-than-20-kg
#11
Mary Hunt Martin, Shabana Shahanavaz, Lynn F Peng, Jeremy D Asnes, Michelle Riley, William E Hellenbrand, David T Balzer, Robert G Gray, Doff B McElhinney
BACKGROUND: Since FDA approval of the Melody valve, transcatheter pulmonary valve replacement (TPVR) has been offered to an expanding population. Limited data exist regarding the safety and feasibility of TPVR in smaller patients. METHODS: All patients weighing <20 kg who underwent catheterization for percutaneous TPVR at four centers were reviewed. RESULTS: Of the 51 patients reviewed, 43 (84%) had successful valve implantation and 8 (16%) were found not to be candidates due to access veins too small (n = 3), coronary artery/aortic root compression (n = 3), and RVOT too large (n = 2)...
February 15, 2018: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29186212/hospitalist-perspective-of-interactions-with-medicine-subspecialty-consult-services
#12
Traci N Adams, Joanna Bonsall, Daniel Hunt, Alberto Puig, Jeremy B Richards, Liyang Yu, Jakob I McSparron, Nainesh Shah, Jonathan Weissler, Eli M Miloslavsky
BACKGROUND: Medicine subspecialty consultation is becoming increasingly important in inpatient medicine. OBJECTIVE: We conducted a survey study in which we examined hospitalist practices and attitudes regarding medicine subspecialty consultation. DESIGN AND SETTING: The survey instrument was developed by the authors based on prior literature and administered online anonymously to hospitalists at 4 academic medical centers in the United States...
November 22, 2017: Journal of Hospital Medicine: An Official Publication of the Society of Hospital Medicine
https://www.readbyqxmd.com/read/29167096/jeremy-hunt-must-consult-properly-on-accountable-care-organisations
#13
Allyson Pollock, Peter Roderick
No abstract text is available yet for this article.
November 22, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29068735/recruit-and-retain-planning-to-expand-the-mental-healthcare-workforce
#14
Alan Glasper
Emeritus Professor Alan Glasper, University of Southampton, discusses an initiative by health secretary Jeremy Hunt to expand the mental health workforce of the NHS in England.
October 26, 2017: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/28957516/stags-hawks-and-doves-social-evolution-theory-and-individual-variation-in-cooperation
#15
Jeremy Van Cleve
One of the triumphs of evolutionary biology is the discovery of robust mechanisms that promote the evolution of cooperative behaviors even when cooperation reduces the fertility or survival of cooperators. These mechanisms include, kin selection, reciprocity, and direct benefits to cooperation that are often nonlinear. Though they have been extensively studied separately, investigating the joint action of these mechanisms has been more difficult. Moreover, how these mechanisms shape variation in cooperation is not well known...
September 1, 2017: Integrative and Comparative Biology
https://www.readbyqxmd.com/read/28953817/working-in-psychiatry-in-new-zealand-experiences-of-international-non-new-zealand-medical-graduates
#16
Ahmed Hankir, Mohammad Shuaib, Sohail Akthtar, Aala Ali, Rashid Zaman
On the 11(th) of February 2016, the Health Secretary in the United Kingdom (UK) Jeremy Hunt announced his plan to impose the Junior Doctor Contract despite thousands of healthcare professionals storming the streets of Westminster in defiant protest. A leading member of the Royal College of Psychiatrists Psychiatric Trainee Committee described the Junior Doctor Contract as 'poisonous', exclaiming that it would be a 'disaster for mental health' and that it would 'disincentivize doctors to work in an already desperately under-resourced specialty'...
September 2017: Psychiatria Danubina
https://www.readbyqxmd.com/read/28812510/make-jeremy-hunt-read-ns
#17
Penny Mannings
Jeremy Hunt should be put in a darkened room with a supply of Nursing Standard and - over a 12-hour shift with a snatched toilet break/cup of coffee - forced to read from cover to cover.
August 16, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28801307/loss-of-mutl-disrupts-chk2-dependent-cell-cycle-control-through-cdk4-6-to-promote-intrinsic-endocrine-therapy-resistance-in-primary-breast-cancer
#18
Svasti Haricharan, Nindo Punturi, Purba Singh, Kimberly R Holloway, Meenakshi Anurag, Jacob Schmelz, Cheryl Schmidt, Jonathan T Lei, Vera Suman, Kelly Hunt, John A Olson, Jeremy Hoog, Shunqiang Li, Shixia Huang, Dean P Edwards, Shyam M Kavuri, Matthew N Bainbridge, Cynthia X Ma, Matthew J Ellis
Significant endocrine therapy-resistant tumor proliferation is present in ≥20% of estrogen receptor-positive (ER+ ) primary breast cancers and is associated with disease recurrence and death. Here, we uncover a link between intrinsic endocrine therapy resistance and dysregulation of the MutL mismatch repair (MMR) complex ( MLH1/3 , PMS1/2 ), and demonstrate a direct role for MutL complex loss in resistance to all classes of endocrine therapy. We find that MutL deficiency in ER+ breast cancer abrogates CHK2-mediated inhibition of CDK4, a prerequisite for endocrine therapy responsiveness...
October 2017: Cancer Discovery
https://www.readbyqxmd.com/read/28721782/review-body-reaction
#19
Karen Chilver
Health secretary Jeremy Hunt has pledged to listen to what the pay review body (RB) has to say about the pay cap for nurses. That's all very well, but it is worth remembering that he voted against scrapping the cap in a Commons vote in June. So we won't be holding our breaths for a change of heart.
July 19, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28659074/health-secretary-sympathetic-about-nurses-case-for-pay-rise
#20
Matthew Mckew
Health secretary Jeremy Hunt (pictured) used his address to the NHS Confederation conference last month to announce renewed talks with the RCN over nurses' pay.
June 29, 2017: Nursing Management (Harrow)
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