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https://www.readbyqxmd.com/read/29153776/francisella-noatunensis-subspecies-noatunensis-clpb-deletion-mutant-impairs-development-of-francisellosis-in-a-zebrafish-model
#1
Elisabeth O Lampe, Carl Zingmark, Julia I Tandberg, Ida Marie P Thrane, Espen Brudal, Anders Sjöstedt, Hanne C Winther-Larsen
BACKGROUND: Francisella noatunensis ssp. noatunensis (F.n.n.) is the causative agent of francisellosis in Atlantic cod and constitutes one of the main challenges for future aquaculture on this species. A facultative intracellular bacterium like F.n.n. exert an immunologic challenge against which live attenuated vaccines in general are most effective. Thus, we constructed a deletion in the F.n.n. clpB gene as ΔclpB mutants are among the most promising vaccine candidates in human pathogenic Francisella...
November 16, 2017: Vaccine
https://www.readbyqxmd.com/read/29151831/a-low-proportion-of-malnourished-patients-receive-nutrition-treatment-results-from-nutritionday
#2
C Henriksen, I M Gjelstad, H Nilssen, R Blomhoff
NutritionDay is a yearly point-prevalence study of malnutrition in hospitals from more than 50 countries. The aim of the present study was to quantify the frequency of malnutrition and the proportion of malnourished patients receiving nutritional treatment in two university hospitals in Norway using data from nutritionDay. All units at Oslo University Hospital (OUH) and University Hospital of Northern Norway (UNN) were invited to participate in nutritionDay 2014, and 28 out of 85 eligible units agreed to take part...
2017: Food & Nutrition Research
https://www.readbyqxmd.com/read/29146640/lipid-profiles-and-determinants-of-total-cholesterol-and-hypercholesterolaemia-among-25-74-year-old-urban-and-rural-citizens-of-the-yangon-region-myanmar-a-cross-sectional-study
#3
Aung Soe Htet, Marte Karoline Kjøllesdal, Wai Phyo Aung, Aye Nyein Moe Myint, Win Thuzar Aye, Myint Myint Wai, Than Than Nu, Ei Mon Hla, Pyone Pyone Soe, Nan Wut Yi Tun, Naw Angela, Mya Mya Khaing, Aung Kyaw Htoo, Soe Tun, Pai Thitsar, Theeoo Lwin, San San Wai, Thi Thi Aung, Khin Aye Thant, Wai Wai Aung Po, Seng Taung Gauzam, Tun Tun Naing, Thet Min Tun, Khin San Myint, Kyi Kyi Oo, Nang Kee Myu Mang, Soe Moe Naing, Ko Ko Zaw, Marius Bergsmark Bjertness, Lhamo Yangchen Sherpa, Win Myint Oo, Hein Stigum, Espen Bjertness
OBJECTIVE: The first is to estimate the prevalence of dyslipidaemia (hypercholesterolaemia, hypertriglyceridaemia, high low-density lipoprotein (LDL) level and low high-density lipoprotein (HDL) level), as well as the mean levels of total cholesterol, triglyceride, LDL and HDL, in the urban and rural Yangon Region, Myanmar. The second is to investigate the association between urban-rural location and total cholesterol. DESIGN: Two cross-sectional studies using the WHO STEPS methodology...
November 15, 2017: BMJ Open
https://www.readbyqxmd.com/read/29135191/virkelighetsdata
#4
Kashif Waqar Faiz, Espen Saxhaug Kristoffersen
No abstract text is available yet for this article.
November 14, 2017: Tidsskrift for Den Norske Lægeforening: Tidsskrift for Praktisk Medicin, Ny Række
https://www.readbyqxmd.com/read/29132737/discordance-between-bioelectrical-impedance-vector-analysis-and-the-new-espen-definition-of-malnutrition-for-the-diagnosis-of-hospital-malnutrition
#5
Edgar Dehesa-López, Jesús Israel Martínez-Felix, Arturo Ruiz-Ramos, Ximena Atilano-Carsi
BACKGROUND & AIMS: No universally accepted diagnostic criteria for malnutrition are available to date. The aim was to assess the concordance for the diagnosis of hospital malnutrition between the bioelectrical impedance vector analysis (BIVA) and the new definition of malnutrition proposed by the European Society for Clinical Nutrition and Metabolism (ESPEN). METHODS: A total of 140 adult hospitalized patients were included. The malnutrition risk was assessed by the Nutritional Risk Screening...
April 2017: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/29130705/disability-and-its-influence-in-nutritional-assessment-tools-in-elderly-people-living-in-nursing-homes
#6
Beatriz Lardiés-Sánchez, Alejandro Sanz-París, Javier Pérez-Nogueras, Antonio Serrano-Oliver, María Elena Torres-Anoro, María Dolores Ballesteros-Pomar
INTRODUCTION: Poor nutritional status is associated with increased morbidity and mortality, especially in older people. OBJECTIVE: The aim of this study was to assess nutritional status in elderly nursing home residents with different nutritional test, and to determine which parameters used for nutritional assessment can be carried out in this population, which usually have a high prevalence of functionally dependent residents. METHODS: A cross-sectional study was performed in 383 elderly...
October 24, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/29129465/developing-a-model-for-measuring-fear-of-pain-in-norwegian-samples-the-fear-of-pain-questionnaire-norway
#7
Sara M Vambheim, Peter Solvoll Lyby, Per M Aslaksen, Magne Arve Flaten, Ole Åsli, Espen Bjørkedal, Laila M Martinussen
BACKGROUND: Fear of pain is highly correlated with pain report and physiological measures of arousal when pain is inflicted. The Fear of Pain Questionnaire III (FPQ-III) and The Fear of Pain Questionnaire Short Form (FPQ-SF) are self-report inventories developed for assessment of fear of pain (FOP). A previous study assessed the fit of the FPQ-III and the FPQ-SF in a Norwegian non-clinical sample and proved poor fit of both models. This inspired the idea of testing the possibility of a Norwegian FOP-model...
November 9, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29122637/side-effect-burden-of-antipsychotic-drugs-in-real-life-impact-of-gender-and-polypharmacy
#8
Trude Seselie Jahr Iversen, Nils Eiel Steen, Ingrid Dieset, Sigrun Hope, Ragni Mørch, Erlend Strand Gardsjord, Kjetil Nordbø Jørgensen, Ingrid Melle, Ole A Andreassen, Espen Molden, Erik G Jönsson
BACKGROUND: Antipsychotic-associated side effects are well known and represent a significant treatment challenge. Still, few large studies have investigated the overall side effect burden of antipsychotics in real-life settings. OBJECTIVE: To describe the occurrence of side effects and perceived burden of antipsychotics in a large naturalistic sample, taking polypharmacy and patient characteristics into account. METHOD: Patients (n=1087) with psychotic disorders were assessed for side effects using the Udvalg for Kliniske Undersøgelser (UKU) side effect rating scale in addition to assessment of clinical and pharmacological data...
November 6, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29121906/impaired-contractile-function-of-the-supraspinatus-in-the-acute-period-following-a-rotator-cuff-tear
#9
Ana P Valencia, Shama R Iyer, Espen E Spangenburg, Mohit N Gilotra, Richard M Lovering
BACKGROUND: Rotator cuff (RTC) tears are a common clinical problem resulting in adverse changes to the muscle, but there is limited information comparing histopathology to contractile function. This study assessed supraspinatus force and susceptibility to injury in the rat model of RTC tear, and compared these functional changes to histopathology of the muscle. METHODS: Unilateral RTC tears were induced in male rats via tenotomy of the supraspinatus and infraspinatus...
November 9, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29117871/language-difficulties-and-internalizing-problems-bidirectional-associations-from-18-months-to-8-years-among-boys-and-girls
#10
Siri Saugestad Helland, Espen Røysamb, Mari Vaage Wang, Kristin Gustavson
Studies have shown that early language difficulties are associated with later internalizing problems. Less is known about the nature of the association: the bidirectional relationship over time, the role of different types of language difficulties, and gender differences. The present study examined bidirectional longitudinal associations between parent-rated language difficulties and internalizing problems in a four-wave cross-lagged model from 18 months to 8 years. Data from the Norwegian Mother and Child Cohort Study were used (N = 114,000)...
November 9, 2017: Development and Psychopathology
https://www.readbyqxmd.com/read/29114615/risk-of-carotid-blowout-after-reirradiation-with-particle-therapy
#11
Jon Espen Dale, Silvia Molinelli, Elisa Ciurlia, Mario Ciocca, Maria Bonora, Viviana Vitolo, Alfredo Mirandola, Stefania Russo, Roberto Orecchia, Olav Dahl, Piero Fossati
Purpose: Carotid blowout (CB) is a serious complication in retreatment of neoplasms in the head and neck (H&N) region. Rates seem to increase in hypofractionated or accelerated hyperfractionated regimens. In this study, we investigate the CB rate and the cumulative doses received by the carotid artery (CA) in a cohort of patients who were reirradiated at CNAO with particle therapy in the H&N region. Methods and materials: The dosimetric information, medical records, and tumor characteristics of 96 patients were analyzed...
July 2017: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29106641/the-mar-databases-development-and-implementation-of-databases-specific-for-marine-metagenomics
#12
Terje Klemetsen, Inge A Raknes, Juan Fu, Alexander Agafonov, Sudhagar V Balasundaram, Giacomo Tartari, Espen Robertsen, Nils P Willassen
We introduce the marine databases; MarRef, MarDBand MarCat (https://mmp.sfb.uit.no/databases/), which are publicly available resources that promote marine research and innovation. These data resources, which have been implemented in the Marine Metagenomics Portal (MMP) (https://mmp.sfb.uit.no/), are collections of richly annotated and manually curated contextual (metadata) and sequence databases representing three tiers of accuracy. While MarRef is a database for completely sequenced marine prokaryotic genomes, which represent a marine prokaryote reference genome database, MarDB includes all incomplete sequenced prokaryotic genomes regardless level of completeness...
November 2, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29103922/17%C3%AE-estradiol-directly-lowers-mitochondrial-membrane-microviscosity-and-improves-bioenergetic-function-in-skeletal-muscle
#13
Maria J Torres, Kim A Kew, Terence E Ryan, Edward Ross Pennington, Chien-Te Lin, Katherine A Buddo, Amy M Fix, Cheryl A Smith, Laura A Gilliam, Sira Karvinen, Dawn A Lowe, Espen E Spangenburg, Tonya N Zeczycki, Saame Raza Shaikh, P Darrell Neufer
Menopause results in a progressive decline in 17β-estradiol (E2) levels, increased adiposity, decreased insulin sensitivity, and a higher risk for type 2 diabetes. Estrogen therapies can help reverse these effects, but the mechanism(s) by which E2 modulates susceptibility to metabolic disease is not well understood. In young C57BL/6N mice, short-term ovariectomy decreased-whereas E2 therapy restored-mitochondrial respiratory function, cellular redox state (GSH/GSSG), and insulin sensitivity in skeletal muscle...
November 1, 2017: Cell Metabolism
https://www.readbyqxmd.com/read/29097387/neopterin-as-an-effect-modifier-of-the-cardiovascular-risk-predicted-by-total-homocysteine-a-prospective-2-cohort-study
#14
Espen Ø Bjørnestad, Robert A Borsholm, Gard F T Svingen, Eva R Pedersen, Reinhard Seifert, Øivind Midttun, Per M Ueland, Grethe S Tell, Kaare H Bønaa, Ottar Nygård
BACKGROUND: Plasma total homocysteine (tHcy) is related to plasma neopterin, an indicator of interferon-γ-mediated immune activation, and both biomarkers positively predict cardiovascular risk. We examined whether the association between tHcy and subsequent risk of acute myocardial infarction (AMI) was modified by systemic concentrations of neopterin and C-reactive protein among patients with coronary heart disease. METHODS AND RESULTS: By Cox modeling, we explored the association between tHcy and risk of AMI in 4164 patients with suspected stable angina pectoris...
November 2, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29082524/survival-in-neuroendocrine-neoplasms-a-report-from-a-large-norwegian-population-based-study
#15
Raziye Boyar Cetinkaya, Bjarte Aagnes, TorÅge Myklebust, Espen Thiis-Evensen
Neuroendocrine neoplasms (NENs) are heterogeneous tumors originating from neuroendocrine cells. Their malignant potential varies from indolence to high-grade malignancy (carcinomas). We studied the survival of all NENs in Norway according to malignant potential and different primary sites. We identified all NEN cases diagnosed in 1993-2015 and reported to the national population-based Cancer Registry of Norway. We included 62 morphological types. According to morphological characteristics and known disease behavior, we stratified the tumors into two different groups: low/intermediate aggressiveness and high aggressiveness...
October 30, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29076608/efficient-water-reduction-with-sp3-sp3-diboron-4-compounds-application-to-hydrogenations-h-d-exchange-reactions-and-carbonyl-reductions
#16
Troels Skrydstrup, Mathias Flinker, Hongfei Yin, René Juhl, Espen Eikeland, Jacob Overgaard, Dennis Nielsen
A series of crystalline sp3-sp3 diboron(4) compounds were synthesized and shown to promote the facile reduction of water with dihydrogen formation. The application of these diborons as simple and effective dihydrogen and dideuterium sources was demonstrated by conducting a series of selective reductions of alkynes and alkenes and hydrogen-deuterium exchange reactions with two-chamber reactors. Finally, as the water reduction reaction generates an intermediate borohydride species, a range of aldehydes and ketones could be reduced with water as the hydride source...
October 27, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/29073891/changes-in-prevalence-awareness-treatment-and-control-of-hypertension-from-2004-to-2014-among-25-74-year-old-citizens-in-the-yangon-region-myanmar
#17
Aung Soe Htet, Marius B Bjertness, Win Myint Oo, Marte Karoline Kjøllesdal, Lhamo Y Sherpa, Ko Ko Zaw, Ko Ko, Hein Stigum, Haakon E Meyer, Espen Bjertness
BACKGROUND: Hypertension is the leading risk factor for cardiovascular diseases, and little is known about trends in prevalence, awareness, treatment and the control of hypertension in Myanmar. This study aims at evaluating changes from 2004 to 2014 in the prevalence, awareness, treatment and control of hypertension in the Yangon Region, Myanmar, and to compare associations between hypertension and selected socio-demographic, behavioural- and metabolic risk factors in 2004 and 2014. METHODS: In 2004 and 2014, household-based cross-sectional studies were conducted in urban and rural areas of Yangon Region using the WHO STEPS protocol...
October 26, 2017: BMC Public Health
https://www.readbyqxmd.com/read/29064734/characteristics-of-general-movements-in-preterm-infants-assessed-by-computer-based-video-analysis
#18
Lars Adde, Hong Yang, Rannei Sæther, Alexander Refsum Jensenius, Espen Ihlen, Jia-Yan Cao, Ragnhild Støen
BACKGROUND: Previous evidence suggests that the variability of the spatial center of infant movements, calculated by computer-based video analysis software, can identify fidgety general movements (GMs) and predict cerebral palsy. AIM: To evaluate whether computer-based video analysis quantifies specific characteristics of normal fidgety movements as opposed to writhing general movements. METHODS: A longitudinal study design was applied. Twenty-seven low-to moderate-risk preterm infants (20 boys, 7 girls; mean gestational age 32 [SD 2...
October 24, 2017: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/29054049/individual-variability-in-clinical-effect-and-tolerability-of-opioid-analgesics-importance-of-drug-interactions-and-pharmacogenetics
#19
REVIEW
Vigdis Solhaug, Espen Molden
BACKGROUND: As pain is often a comorbid condition, many patients use opioid analgesics in combination with several other drugs. This implies a generally increased risk of drug interactions, which along with inherent pharmacogenetic variability and other factors may cause differences in therapeutic response of opioids. AIM: To provide an overview of interactions and pharmacogenetic variability of relevance for individual differences in effect and tolerability of opioid analgesics, which physicians and other healthcare professionals should be aware of in clinical practice...
October 17, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29031194/the-prevalence-and-characteristics-of-epilepsy-in-patients-with-multiple-sclerosis-in-nordland-county-norway
#20
Espen Benjaminsen, Kjell-Morten Myhr, Karl B Alstadhaug
PURPOSE: The prevalence of epilepsy among patients with multiple sclerosis (MS) has been found higher than in the general population. Although cortical pathology may be involved, the causal link between MS and epileptic seizures is still unclear. We aimed to identify and describe the patients with active epilepsy in a previously described population based MS-cohort. METHODS: Medical records of all patients with MS in Nordland County on January 1, 2010, were scrutinizing for evidence of comorbid seizures and epilepsy...
October 6, 2017: Seizure: the Journal of the British Epilepsy Association
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