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https://www.readbyqxmd.com/read/29325448/impact-of-cyp2c19-genotype-on-escitalopram-exposure-and-therapeutic-failure-a-retrospective-study-based-on-2-087-patients
#1
Marin M Jukić, Tore Haslemo, Espen Molden, Magnus Ingelman-Sundberg
OBJECTIVE: The antidepressant escitalopram is predominantly metabolized by the polymorphic CYP2C19 enzyme. The authors investigated the effect of CYP2C19 genotype on exposure and therapeutic failure of escitalopram in a large patient population. METHOD: A total of 4,228 escitalopram serum concentration measurements from 2,087 CYP2C19-genotyped patients 10-30 hours after drug intake were collected retrospectively from the drug monitoring database at Diakonhjemmet Hospital in Oslo...
January 12, 2018: American Journal of Psychiatry
https://www.readbyqxmd.com/read/29321158/response-to-calprotectin-is-not-independent-from-baseline-erosion-in-predicting-radiological-progression-in-early-rheumatoid-arthritis-by-chevreau-et-al
#2
Maria Karolina Jonsson, Nina Paulshus Sundlisæter, Hilde Haugedal Nordal, Hilde Berner Hammer, Anna-Birgitte Aga, Désirée van der Heijde, Tore Kristian Kvien, Bjørg-Tilde Svanes Fevang, Siri Lillegraven, Espen Andre Haavardsholm
No abstract text is available yet for this article.
January 10, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29276430/young-adults-reasons-for-dropout-from-residential-substance-use-disorder-treatment
#3
Kristoffer Nordheim, Espen Walderhaug, Ståle Alstadius, Ann Kern-Godal, Espen Arnevik, Fanny Duckert
Dropout from substance use disorder treatment is usually investigated and understood from a perspective of quantitative patient-related factors. Patients' own perspectives (user perspective) are rarely reported. This study, therefore, aimed to explore patients' own understanding of their dropout from residential substance use disorder treatment. The participants were 15 males and females, aged 19-29 years, who had dropped out of residential substance use disorder treatment at the Department of Addiction Treatment, Oslo University Hospital, Norway...
January 2018: Qualitative Social Work: QSW: Research and Practice
https://www.readbyqxmd.com/read/29274834/espen-guideline-clinical-nutrition-in-neurology
#4
Rosa Burgos, Irene Bretón, Emanuele Cereda, Jean Claude Desport, Rainer Dziewas, Laurence Genton, Filomena Gomes, Pierre Jésus, Andreas Leischker, Maurizio Muscaritoli, Kalliopi-Anna Poulia, Jean Charles Preiser, Marjolein Van der Marck, Rainer Wirth, Pierre Singer, Stephan C Bischoff
Neurological diseases are frequently associated with swallowing disorders and malnutrition. Moreover, patients with neurological diseases are at increased risk of micronutrient deficiency and dehydration. On the other hand, nutritional factors may be involved in the pathogenesis of neurological diseases. Multiple causes for the development of malnutrition in patients with neurological diseases are known including oropharyngeal dysphagia, impaired consciousness, perception deficits, cognitive dysfunction, and increased needs...
September 22, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29273642/transcriptional-and-functional-profiling-defines-human-small-intestinal-macrophage-subsets
#5
Anna Bujko, Nader Atlasy, Ole J B Landsverk, Lisa Richter, Sheraz Yaqub, Rune Horneland, Ole Øyen, Einar Martin Aandahl, Lars Aabakken, Hendrik G Stunnenberg, Espen S Bækkevold, Frode L Jahnsen
Macrophages (Mfs) are instrumental in maintaining immune homeostasis in the intestine, yet studies on the origin and heterogeneity of human intestinal Mfs are scarce. Here, we identified four distinct Mf subpopulations in human small intestine (SI). Assessment of their turnover in duodenal transplants revealed that all Mf subsets were completely replaced over time; Mf1 and Mf2, phenotypically similar to peripheral blood monocytes (PBMos), were largely replaced within 3 wk, whereas two subsets with features of mature Mfs, Mf3 and Mf4, exhibited significantly slower replacement...
December 22, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29244063/maternal-psychosocial-stress-associates-with-increased-risk-of-asthma-development-in-offspring
#6
Maria C Magnus, Rosalind J Wright, Espen Røysamb, Christine L Parr, Øystein Karlstad, Christian M Page, Per Nafstad, Siri E Håberg, Stephanie J London, Wenche Nystad
Prenatal maternal psychosocial stress might influence childhood asthma development. Evaluating paternal psychosocial stress and conducting a sibling comparison could provide further insight into the role of unmeasured confounding. We examined the associations of parental psychosocial stress during and after pregnancy with asthma at 7 years in the Norwegian Mother and Child Cohort Study (n = 63,626). Measures of psychosocial stress included lifetime major depressive symptoms, current anxiety/depression symptoms, use of antidepressants, anxiolytics and/or hypnotics, life satisfaction, relationship satisfaction, work stress and social support...
December 13, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29220180/securamine-derivatives-from-the-arctic-bryozoan-securiflustra-securifrons
#7
Kine Ø Hansen, Johan Isaksson, Annette Bayer, Jostein A Johansen, Jeanette H Andersen, Espen Hansen
Bryozoans belonging to the Flustridae family have proven to be a rich source of structurally unique secondary metabolites. As part of our continuing search for bioactive secondary metabolites from Arctic marine invertebrates, the organic extract of Securiflustra securifrons was examined. This resulted in the isolation of three new halogenated, hexacyclic indole-imidazole alkaloids, securamines H-J (1-3), together with the previously reported compounds securamines C (4) and E (5). The structures of the new compounds were elucidated by spectroscopic methods including 1D and 2D NMR and analysis of HRMS data...
December 8, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/29218433/s8orf2-protein-of-infectious-salmon-anaemia-virus-is-a-rna-silencing-suppressor-and-interacts-with-salmon-salar-mov10-ssmov10-of-the-host-rnai-machinery
#8
Vandana Thukral, Bhavna Varshney, Rimatulhana B Ramly, Sanket S Ponia, Sumona Karjee Mishra, Christel M Olsen, Akhil C Banerjea, Sunil K Mukherjee, Rana Zaidi, Espen Rimstad, Sunil K Lal
The infectious salmon anaemia virus (ISAV) is a piscine virus, a member of Orthomyxoviridae family. It encodes at least 10 proteins from eight negative-strand RNA segments. Since ISAV belongs to the same virus family as Influenza A virus, with similarities in protein functions, they may hence be characterised by analogy. Like NS1 protein of Influenza A virus, s8ORF2 of ISAV is implicated in interferon antagonism and RNA-binding functions. In this study, we investigated the role of s8ORF2 in RNAi suppression in a well-established Agrobacterium transient suppression assay in stably silenced transgenic Nicotiana xanthi...
December 7, 2017: Virus Genes
https://www.readbyqxmd.com/read/29212771/establishment-of-a-surgical-bile-duct-injection-technique-giving-direct-access-to-the-bile-ducts-for-studies-of-the-murine-biliary-tree
#9
Natalie Lie Berntsen, Bjarte Fosby, Laura Valestrand, Corey Tan, Henrik Reims, Elisabeth Schrumpf, Tom H Karlsen, Pål-Dag Line, Espen Melum
Cholangiopathies are progressive disorders with largely unknown pathoetiology and limited treatment options. We aimed to develop a novel surgical technique with direct access to the bile ducts that would complement existing mouse models of cholestasis, biliary inflammation and fibrosis, and present a new route of administration for testing of potential treatment strategies. We developed a surgical technique to access the murine biliary tree by injection of different solvents through catheterization of the gall bladder with simultaneous clamping of the common bile duct...
December 6, 2017: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/29199429/reply-to-the-letter-by-min-et%C3%A2-al
#10
Espen Saxhaug Kristoffersen, Knut Stavem, Christofer Lundqvist, Michael Bjørn Russell
No abstract text is available yet for this article.
January 1, 2017: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/29197231/uptake-and-effects-of-2-4-6-trinitrotoluene-tnt-in-juvenile-atlantic-salmon-salmo-salar
#11
Espen Mariussen, Siv Marie Stornes, Kari Oline Bøifot, Bjørn Olav Rosseland, Brit Salbu, Lene Sørlie Heier
Organ specific uptake and depuration, and biological effects in Atlantic salmon (Salmo salar) exposed to 2, 4, 6-trinitrotoluene (TNT) were studied. Two experiments were conducted, the first using radiolabeled TNT (14C-TNT, 0.16mg/L) to study uptake (48h) and depuration (48h), while the second experiment focused on physiological effects in fish exposed to increasing concentrations of unlabeled TNT (1μg-1mg/L) for 48h. The uptake of 14C-TNT in the gills and most of the organs increased rapidly during the first 6h of exposure (12h in the brain) followed by a rapid decrease even though the fish were still exposed to TNT in the water...
November 24, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/29196890/malnutrition-and-sarcopenia-in-a-large-cohort-of-patients-with-systemic-sclerosis
#12
C Caimmi, P Caramaschi, A Venturini, E Bertoldo, E Vantaggiato, O Viapiana, M Ferrari, G Lippi, L Frulloni, M Rossini
Systemic sclerosis (SSc) is an autoimmune disease which may lead to malnutrition. Previous studies have defined it with different criteria. No thorough evaluations of sarcopenia in SSc are available. The aim of the present study was to assess the prevalence and the potential association of malnutrition and sarcopenia in a large cohort of SSc cases. A total of 141 SSc consecutive outpatients were enrolled. Body composition was analyzed by densitometry. Malnutrition was defined according to recently published ESPEN criteria, whereas sarcopenia was diagnosed in patients with reduced skeletal muscle index...
December 1, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/29194752/the-regulatory-role-of-the-oral-commensal-streptococcus-mitis-on-human-monocytes
#13
Stian André Engen, Olav Schreurs, Fernanda Petersen, Inger Johanne Schytte Blix, Espen S Baekkevold, Karl Schenck
Streptococcus mitis colonizes all niches of the human oral cavity from early infancy and throughout life. Monocytes patrol blood vessels, lymphoid and non-lymphoid tissues, and migrate into infected tissue where they participate in the inflammatory cascade and immune regulation. Here, we studied the effect of S. mitis on monocytes. Transcriptome analysis of monocytes exposed to S. mitis (SmMo) revealed increased transcription of chemotactic factors (CCL2, CCL3, CCL20, CXCL1, CXCL2) and cytokines (IL1A, IL1B, IL6, IL23, IL36G, TNF), indicating that S...
December 1, 2017: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/29187051/the-new-european-society-for-clinical-nutrition-and-metabolism-definition-of-malnutrition-application-for-nutrition-assessment-and-prediction-of-morbimortality-in-an-emergency-service
#14
Jaqueline da Silva Fink, Aline Marcadenti, Estela Iraci Rabito, Flávia Moraes Silva
BACKGROUND: Recently, the European Society for Clinical Nutrition and Metabolism (ESPEN) provided novel consensus criteria for malnutrition diagnosis. This study aimed to evaluate the applicability of this instrument in combination with different nutrition screening tools (1) to identify malnutrition and (2) to predict morbidity and mortality in hospitalized patients. MATERIALS AND METHODS: Observational prospective study in 750 adults admitted to the emergency service of a tertiary public hospital...
March 1, 2017: JPEN. Journal of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29186497/for-as-long-as-necessary-examining-30-years-of-merck-co-inc-s-focus-on-achieving-elimination-of-onchocerciasis-and-lymphatic-filariasis
#15
Kenneth M Gustavsen, Brenda D Colatrella, Theresa McCoy
Established by Merck & Co., Inc. (known as MSD outside of the United States and Canada) in 1987, the Mectizan Donation Program (MDP) is the longest running disease-specific program of its kind. Initially aimed at control of onchocerciasis (river blindness), the company expanded its commitment through the MDP in 1998 to include lymphatic filariasis (LF). Both diseases are now candidates for elimination and the company is engaged in several global partnerships to help advance towards that goal. To support the steadily growing demand from country-led disease elimination programs, the company has put in place several administrative and operational improvements...
November 23, 2017: International Health
https://www.readbyqxmd.com/read/29185003/ultrasound-measurements-of-achilles-tendon-length-using-skin-markings-are-more-reliable-than-extended-field-of-view-imaging
#16
Espen Femmo Brouwer, Ståle Bergman Myhrvold, Jūratė Šaltytė Benth, Sigurd Erik Hoelsbrekken
PURPOSE: Elongation of the Achilles tendon has been associated with poorer function in patients treated for ruptures. This has led to the development of various ultrasound-based measurements, and the purpose of the present study was to compare the reliability of three ultrasound-based measuring procedures. METHODS: Twenty healthy individuals (40 tendons) were assessed by two testers at two occasions, 12 weeks apart. The tendon length was measured from the calcaneal insertion to the mid-sagittal muscle tendon junction (MTJ) using skin markings or extended-field-of-view (EFOV) imaging, or from the calcaneal insertion to the distal medial MTJ using skin markings...
November 28, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29181918/umoralsk-ikke-%C3%A3-hjelpe
#17
Espen Robert Collett
No abstract text is available yet for this article.
November 28, 2017: Tidsskrift for Den Norske Lægeforening: Tidsskrift for Praktisk Medicin, Ny Række
https://www.readbyqxmd.com/read/29175562/utilisation-and-polypharmacy-aspects-of-antiepileptic-drugs-in-elderly-versus-younger-patients-with-epilepsy-a-pharmacoepidemiological-study-of-cns-active-drugs-in-norway-2004-2015
#18
Arton Baftiu, Silje Andrea Feet, Pål Gunnar Larsson, Margrete Larsen Burns, Oliver Henning, Erik Sætre, Espen Molden, Anne Gerd Granas, Svein I Johannessen, Cecilie Johannessen Landmark
BACKGROUND AND PURPOSE: Many patients with epilepsy use antiepileptic drugs (AEDs) in combination. The elderly is a vulnerable group regarding polypharmacy. The purpose of this study was to investigate changes in utilisation of AEDs, and the extent of polypharmacy with other CNS-active drugs in elderly versus younger patients in Norway. METHODS: This pharmacoepidemiological study included all prescriptions of antiepileptic, antidepressant and antipsychotic drugs from Norwegian pharmacies in the Norwegian Prescription Database (NorPD) (2004-2015)...
November 11, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/29164125/malnutrition-upon-hospital-admission-in-geriatric-patients-why-assess-it
#19
Paolo Orlandoni, Claudia Venturini, Nikolina Jukic Peladic, Annarita Costantini, Mirko Di Rosa, Claudia Cola, Natascia Giorgini, Redenta Basile, Donata Fagnani, Debora Sparvoli, Serenella David
Objective: To assess the prevalence of malnutrition according to the new ESPEN definition in a population of geriatric hospital patients and to determine how malnutrition affects the length of hospital stay (LOS) and hospital mortality. Design: A retrospective analysis of data gathered during nutritional screening surveys carried out three consecutive years, from 2012 to 2014, in an Italian geriatric research hospital (INRCA, Ancona) was performed. On the day of the study, demographic data, data on clinical conditions and the nutritional status of newly admitted patients were collected...
2017: Frontiers in Nutrition
https://www.readbyqxmd.com/read/29162322/do-long-lived-plasma-cells-maintain-a-healthy-microbiota-in-the-gut
#20
REVIEW
Frode L Jahnsen, Espen S Bækkevold, Johannes R Hov, Ole J Landsverk
Disruptions to the gut microbiota have been associated with a variety of diseases. Understanding the underlying mechanisms that regulate the maintenance of a healthy microbiota may therefore have therapeutic implications. Secretory IgA play a unique role in immune-microbiota crosstalk by directly binding to bacteria in the gut lumen. Microbe-specific IgA responses co-develop with the assembly of the gut microbiota during infancy, and resemble those of adults by 2 years postnatally in the healthy host. We propose here that microbiota-specific IgA-producing gut plasma cells generated during infancy live for many decades and contribute to a stable microbiota community...
November 18, 2017: Trends in Immunology
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