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https://www.readbyqxmd.com/read/28344167/protection-and-antibody-reactivity-following-vaccination-of-lumpfish-cyclopterus-lumpus-l-against-atypical-aeromonas-salmonicida
#1
Anita Rønneseth, Gyri T Haugland, Duncan J Colquhoun, Espen Brudal, Heidrun I Wergeland
Atypical Aeromonas salmonicida is frequently associated with disease and mortality in farmed lumpfish (Cyclopterus lumpus L). Challenge experiments using different modes of exposure identified both high and low pathogenic isolates. Intraperitoneal vaccination induced production of high levels of specific antibodies particularly in fish given multiple injections. The immune sera contained antibodies cross reactive with both high and low pathogenic isolates. SDS-PAGE and LC/MSMS analyses showed that the highly virulent isolate expressed the virulence array protein (A-layer) while the less virulent isolate did not...
March 23, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28335455/viral-protein-kinetics-of-piscine-orthoreovirus-infection-in-atlantic-salmon-blood-cells
#2
Hanne Merethe Haatveit, Øystein Wessel, Turhan Markussen, Morten Lund, Bernd Thiede, Ingvild Berg Nyman, Stine Braaen, Maria Krudtaa Dahle, Espen Rimstad
Piscine orthoreovirus (PRV) is ubiquitous in farmed Atlantic salmon (Salmo salar) and the cause of heart and skeletal muscle inflammation. Erythrocytes are important target cells for PRV. We have investigated the kinetics of PRV infection in salmon blood cells. The findings indicate that PRV causes an acute infection of blood cells lasting 1-2 weeks, before it subsides into persistence. A high production of viral proteins occurred initially in the acute phase which significantly correlated with antiviral gene transcription...
March 18, 2017: Viruses
https://www.readbyqxmd.com/read/28333596/to-create-a-consensus-on-malnutrition-diagnostic-criteria
#3
Tommy Cederholm, Gordon L Jensen
During the European Society for Clinical Nutrition and Metabolism (ESPEN) Congress in Copenhagen, Denmark (September 2016), representatives of the 4 largest global parenteral and enteral nutrition (PEN) societies from Europe (ESPEN), the United States (American Society for Parenteral and Enteral Nutrition [ASPEN]), Asia (Parenteral and Enteral Nutrition Society of Asia [PENSA]), and Latin America (Latin American Federation of Parenteral and Enteral Nutrition [FELANPE]) and from national PEN societies around the world met to continue the conversation on how to diagnose malnutrition that started during the Clinical Nutrition Week, Austin, Texas (February 2016)...
March 2017: JPEN. Journal of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28328028/large-area-elemental-imaging-reveals-van-eyck-s-original-paint-layers-on-the-ghent-altarpiece-1432-rescoping-its-conservation-treatment
#4
Geert Van der Snickt, Hélène Dubois, Jana Sanyova, Stijn Legrand, Alexia Coudray, Cécile Glaude, Marie Postec, Piet Van Espen, Koen Janssens
A combination of large-scale and micro-scale elemental imaging, yielding elemental distribution maps obtained by, respectively non-invasive macroscopic X-ray fluorescence (MA-XRF) and by secondary electron microscopy/energy dispersive X-ray analysis (SEM-EDX) and synchrotron radiation-based micro-XRF (SR μ-XRF) imaging was employed to reorient and optimize the conservation strategy of van Eyck's renowned Ghent Altarpiece. By exploiting the penetrative properties of X-rays together with the elemental specificity offered by XRF, it was possible to visualize the original paint layers by van Eyck hidden below the overpainted surface and to simultaneously assess their condition...
March 22, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28323214/immunological-interactions-between-piscine-orthoreovirus-and-salmonid-alphavirus-infections-in-atlantic-salmon
#5
Magnus Vikan Røsæg, Morten Lund, Ingvild Berg Nyman, Turhan Markussen, Vidar Aspehaug, Hilde Sindre, Maria Krudtaa Dahle, Espen Rimstad
Heart and skeletal muscle inflammation (HSMI) and pancreas disease (PD) cause substantial losses in Atlantic salmon (Salmo salar) aquaculture. The respective causative agents, Piscine orthoreovirus (PRV) and Salmonid alphavirus (SAV), are widespread and often concurrently present in farmed salmon. An experimental infection in Atlantic salmon was conducted to study the interaction between the two viruses, including the immunological mechanisms involved. The co-infected fish were infected with PRV four or ten weeks before they were infected with SAV...
March 18, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28321593/association-of-excessive-daytime-sleepiness-with-migraine-and-headache-frequency-in-the-general-population
#6
Knut Stavem, Håvard Anton Kristiansen, Espen Saxhaug Kristoffersen, Kari Jorunn Kværner, Michael Bjørn Russell
BACKGROUND: Some previous studies have postulated an association between migraine and excessive daytime sleepiness (EDS). This study evaluated the association of EDS with migraine and headache frequency in a general population, after adjusting for potential confounding variables. METHODS: The study was a postal survey of a random age and gender-stratified sample of 40,000 persons aged 20 to 80 years old drawn by the National Population Register in Norway. The questionnaire included questions about migraine, headache, the Epworth sleepiness scale (ESS) and various comorbidities...
December 2017: Journal of Headache and Pain
https://www.readbyqxmd.com/read/28294397/monitoring-chemical-and-biological-recovery-at-a-confined-aquatic-disposal-site-oslofjord-norway
#7
Amy M P Oen, Arne Pettersen, Espen Eek, Tormod Glette, Lucy Brooks, Gijs D Breedveld
The recovery of the confined aquatic disposal (CAD) facility located at Malmøykalven in Oslofjord, Norway has been assessed using an array of field measurement techniques. These methods were used prior to the disposal of dredged sediments as well as during 3 annual post-disposal monitoring campaigns. Traditional sampling to assess chemical recovery indicate an immediate reduction in total sediment concentrations and surface sediments can be characterized as having good quality. Deposition of new material indicates that the quality of depositing material at the CAD is stabile and representative of the natural background quality in the area...
March 15, 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/28287775/musculoskeletal-complaints-anxiety-depression-symptoms-and-neuroticism-a-study-of-middle-aged-twins
#8
Olav Vassend, Espen Røysamb, Christopher Sivert Nielsen, Nikolai Olavi Czajkowski
BACKGROUND: Musculoskeletal (MS) complaints are reported commonly, but the extent to which such complaints reflect the severity of site-specific pathology or a more generalized susceptibility to feel pain/discomfort is uncertain. Both site-specific and more widespread MS conditions have been shown to be linked to anxiety and depression, but the nature of this relationship is poorly understood. In the present study the role of neuroticism as a shared risk factor that may possibly explain the co-occurrence between anxiety-depression and MS complaints was investigated...
March 13, 2017: Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association
https://www.readbyqxmd.com/read/28287449/a-physical-activity-reference-data-set-recorded-from-older-adults-using-body-worn-inertial-sensors-and-video-technology-the-adapt-study-data-set
#9
Alan Kevin Bourke, Espen Alexander F Ihlen, Ronny Bergquist, Per Bendik Wik, Beatrix Vereijken, Jorunn L Helbostad
Physical activity monitoring algorithms are often developed using conditions that do not represent real-life activities, not developed using the target population, or not labelled to a high enough resolution to capture the true detail of human movement. We have designed a semi-structured supervised laboratory-based activity protocol and an unsupervised free-living activity protocol and recorded 20 older adults performing both protocols while wearing up to 12 body-worn sensors. Subjects' movements were recorded using synchronised cameras (≥25 fps), both deployed in a laboratory environment to capture the in-lab portion of the protocol and a body-worn camera for out-of-lab activities...
March 10, 2017: Sensors
https://www.readbyqxmd.com/read/28277353/risk-of-adverse-pregnancy-outcome-after-paternal-exposure-to-methotrexate-within-90-days-before-pregnancy
#10
Lasse Karlsen Eck, Thomas Bo Jensen, Dimitrios Mastrogiannis, Arendse Torp-Pedersen, Bjarke Askaa, Torben Kjær Nielsen, Henrik Enghusen Poulsen, Espen Jimenez-Solem, Jon Trærup Andersen
OBJECTIVE: To study the association between paternal exposure to methotrexate within the 90-day period before pregnancy and congenital malformations and stillbirth in the offspring. METHODS: We conducted a nationwide register study. Our cohort consisted of all live births in Denmark between 1997 and 2011 identified from the Medical Birth Registry. Methotrexate-exposed fathers were identified from the National Prescription Registry. From the national Hospital Registry we identified paternity, live births, and stillbirths as well as discharge diagnoses on congenital malformations...
April 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28269364/video-analysis-validation-of-a-real-time-physical-activity-detection-algorithm-based-on-a-single-waist-mounted-tri-axial-accelerometer-sensor
#11
Alan K Bourke, Espen A F Ihlen, Pepijn Van de Ven, John Nelson, Jorunn L Helbostad
We have validated a real-time activity classification algorithm based on monitoring by a body worn system which is potentially suitable for low-power applications on a relatively computationally lightweight processing unit. The algorithm output was validated using annotation data generated from video recordings of 20 elderly volunteers performing both a semi-structured protocol and a free-living protocol. The algorithm correctly identified sitting 75.1% of the time, standing 68.8% of the time, lying 50.9% of the time, and walking and other upright locomotion 82...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28269098/fall-detection-algorithms-for-real-world-falls-harvested-from-lumbar-sensors-in-the-elderly-population-a-machine-learning-approach
#12
Alan K Bourke, Jochen Klenk, Lars Schwickert, Kamiar Aminian, Espen A F Ihlen, Sabato Mellone, Jorunn L Helbostad, Lorenzo Chiari, Clemens Becker
Automatic fall detection will promote independent living and reduce the consequences of falls in the elderly by ensuring people can confidently live safely at home for linger. In laboratory studies inertial sensor technology has been shown capable of distinguishing falls from normal activities. However less than 7% of fall-detection algorithm studies have used fall data recorded from elderly people in real life. The FARSEEING project has compiled a database of real life falls from elderly people, to gain new knowledge about fall events and to develop fall detection algorithms to combat the problems associated with falls...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28268245/psychotropics-and-weak-opioid-analgesics-in-plasma-samples-of-older-hip-fracture-patients-detection-frequencies-and-consistency-with-drug-records
#13
Ragnhild Birkeland Waade, Espen Molden, Mette Irene Martinsen, Monica Hermann, Anette Hylen Ranhoff
AIM: To determine use of psychotropic drugs and weak opioids in hip fracture patients by analysing plasma samples at admission, and compare detected drug frequencies with prescription registry data and drug records. METHODS: Plasma from 250 hip fracture patients ≥65 years sampled at hospital admission were analysed by ultra-performance liquid chromatography - tandem mass spectrometry methods for detection of psychotropic drugs and weak opioid analgesics (alcohol also determined)...
March 7, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28265871/distribution-and-mobility-of-lead-pb-copper-cu-zinc-zn-and-antimony-sb-from-ammunition-residues-on-shooting-ranges-for-small-arms-located-on-mires
#14
Espen Mariussen, Ida Vaa Johnsen, Arnljot Einride Strømseng
An environmental survey was performed on shooting ranges for small arms located on minerotrophic mires. The highest mean concentrations of Pb (13 g/kg), Cu (5.2 g/kg), Zn (1.1 g/kg), and Sb (0.83 g/kg) in the top soil were from a range located on a poor minerotrophic and acidic mire. This range had also the highest concentrations of Pb, Cu, Zn, and Sb in discharge water (0.18 mg/L Pb, 0.42 mg/L Cu, 0.63 mg/L Zn, and 65 μg/L Sb) and subsurface soil water (2.5 mg/L Pb, 0.9 mg/L Cu, 1.6 mg/L Zn, and 0...
March 6, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28258201/endothelial-il-33-expression-is-augmented-by-adenoviral-activation-of-the-dna-damage-machinery
#15
Tor Espen Stav-Noraas, Reidunn J Edelmann, Lars La Cour Poulsen, Olav Sundnes, Danh Phung, Axel M Küchler, Fredrik Müller, Amine A Kamen, Guttorm Haraldsen, Mari Kaarbø, Johanna Hol
IL-33, required for viral clearance by cytotoxic T cells, is generally expressed in vascular endothelial cells in healthy human tissues. We discovered that endothelial IL-33 expression was stimulated as a response to adenoviral transduction. This response was dependent on MRE11, a sensor of DNA damage that can also be activated by adenoviral DNA, and on IRF1, a transcriptional regulator of cellular responses to viral invasion and DNA damage. Accordingly, we observed that endothelial cells responded to adenoviral DNA by phosphorylation of ATM and CHK2 and that depletion or inhibition of MRE11, but not depletion of ATM, abrogated IL-33 stimulation...
March 3, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28255954/adherence-as-a-language-game
#16
REVIEW
Espen Skarstein Kolberg
Non-adherence, i.e. medication intake behavior not corresponding with agreed recommendations, is associated with increased morbidity and death, and it has been estimated that as many as 50% of patients in developed countries are not taking their medications as prescribed. But even as efforts in improving medication adherence over the years have increased, results are inconsistent, with only a minority of clinical trials showing any improvement in both adherence and clinical outcome. Since patient education is central to promoting good medication adherence, and language is integral to education, perhaps an exploration of the meaning and use of language, using the philosophy of Ludwig Wittgenstein, is in order...
March 2, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/28249852/changes-in-drug-disposition-of-lithium-during-pregnancy-a-retrospective-observational-study-of-patient-data-from-two-routine-therapeutic-drug-monitoring-services-in-norway
#17
Andreas Austgulen Westin, Malin Brekke, Espen Molden, Eirik Skogvoll, Marianne Aadal, Olav Spigset
OBJECTIVES: Pregnancy may cause changes in drug disposition, dose requirements and clinical response. For lithium, changes in disposition during pregnancy have so far been explored in a single-dose study on 4 participants only. The aim of this study was to determine the effect of pregnancy on serum levels of lithium in a larger patient material in a naturalistic setting. DESIGN: A retrospective observational study of patient data from 2 routine therapeutic drug monitoring services in Norway, linked to the Medical Birth Registry of Norway...
March 1, 2017: BMJ Open
https://www.readbyqxmd.com/read/28229455/maternal-perinatal-and-concurrent-depressive-symptoms-and-child-behavior-problems-a-sibling-comparison-study
#18
Line C Gjerde, Espen Moen Eilertsen, Ted Reichborn-Kjennerud, Tom A McAdams, Henrik Daae Zachrisson, Imac Maria Zambrana, Espen Røysamb, Kenneth S Kendler, Eivind Ystrom
BACKGROUND: Previous studies have found significant associations between maternal prenatal and postpartum depression and child behavior problems (CBP). The present study investigates whether associations remain in a prospective, longitudinal design adjusted for familial confounding. METHODS: The sample comprised 11,599 families including 17,830 siblings from the Norwegian Mother and Child Cohort study. Mothers reported depressive symptoms at gestational weeks 17 and 30, as well as 6 months, 1...
February 23, 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/28228559/targeting-influenza-virus-hemagglutinin-to-xcr1-dendritic-cells-in-the-absence-of-receptor-mediated-endocytosis-enhances-protective-antibody-responses
#19
Arnar Gudjonsson, Anna Lysén, Sreekumar Balan, Vibeke Sundvold-Gjerstad, Catharina Arnold-Schrauf, Lisa Richter, Espen S Bækkevold, Marc Dalod, Bjarne Bogen, Even Fossum
Targeting Ags to conventional dendritic cells can enhance Ag-specific immune responses. Although most studies have focused on the induction of T cell responses, the mechanisms by which targeting improves Ab responses are poorly understood. In this study we present data on the use of human XCL1 (hXCL1) and hXCL2 fusion vaccines in a murine model. We show that the human chemokines bound type 1 conventional dendritic cells (cDC1), and that immunization with influenza virus hemagglutinin fused to hXCL1 or hXCL2 induced full protection against influenza challenge...
February 22, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28227606/video-analysis-validation-of-a-real-time-physical-activity-detection-algorithm-based-on-a-single-waist-mounted-tri-axial-accelerometer-sensor
#20
Alan K Bourke, Espen A F Ihlen, Pepijn Van de Ven, John Nelson, Jorunn L Helbostad, Alan K Bourke, Espen A F Ihlen, Pepijn Van de Ven, John Nelson, Jorunn L Helbostad, Jorunn L Helbostad, Alan K Bourke, John Nelson, Pepijn Van de Ven, Espen Af Ihlen
We have validated a real-time activity classification algorithm based on monitoring by a body worn system which is potentially suitable for low-power applications on a relatively computationally lightweight processing unit. The algorithm output was validated using annotation data generated from video recordings of 20 elderly volunteers performing both a semi-structured protocol and a free-living protocol. The algorithm correctly identified sitting 75.1% of the time, standing 68.8% of the time, lying 50.9% of the time, and walking and other upright locomotion 82...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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