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https://www.readbyqxmd.com/read/27919240/urban-rural-differences-in-the-prevalence-of-non-communicable-diseases-risk-factors-among-25-74-years-old-citizens-in-yangon-region-myanmar-a-cross-sectional-study
#1
Aung Soe Htet, Marius B Bjertness, Lhamo Y Sherpa, Marte Karoline Kjøllesdal, Win Myint Oo, Haakon E Meyer, Hein Stigum, Espen Bjertness
BACKGROUND: Recent societal and political reforms in Myanmar may upturn the socio-economy and, thus, contribute to the country's health transition. Baseline data on urban-rural disparities in non-communicable disease (NCD) risk factors are not thoroughly described in this country which has been relatively closed for more than five decades. We aim to investigate urban-rural differences in mean values and the prevalence of selected behavioral and metabolic risk factors for non-communicable diseases and 10-years risk in development of coronary heart diseases (CHD)...
December 5, 2016: BMC Public Health
https://www.readbyqxmd.com/read/27912077/nlrp3-activation-induces-il-18-synthesis-and-affects-the-epithelial-barrier-function-in-reactive-cholangiocytes
#2
Luca Maroni, Laura Agostinelli, Stefania Saccomanno, Claudio Pinto, Debora Giordano, Chiara Rychlicki, Samuele De Minicis, Luciano Trozzi, Jesus M Banales, Espen Melum, Tom H Karlsen, Antonio Benedetti, Gianluca Svegliati Baroni, Marco Marzioni
Microbial products are thought to influence the progression of cholangiopathies, in particular primary sclerosing cholangitis (PSC). Inflammasomes are molecular platforms that respond to microbial products through the synthesis of proinflammatory cytokines. We investigated the role of inflammasome activation in cholangiocyte response to injury. Nucleotide-binding oligomerization domain (NOD)-like receptor family, pyrin domain-containing protein 3 (Nlrp3) expression was tested in cholangiocytes of normal and cholestatic livers...
November 29, 2016: American Journal of Pathology
https://www.readbyqxmd.com/read/27906019/patterns-of-motor-activity-in-spontaneously-hypertensive-rats-compared-to-wistar-kyoto-rats
#3
Ole Bernt Fasmer, Espen Borgå Johansen
BACKGROUND: Increased motor activity is a defining characteristic of patients with ADHD, and spontaneously hypertensive rats have been suggested to be an animal model of this disorder. In the present study, we wanted to use linear and non-linear methods to explore differences in motor activity patterns in SHR/NCrl rats compared to Wistar Kyoto (WKY/NHsd) rats. METHODS: A total number of 42 rats (23 SHR/NCrl and 19 WKY/NHsd, male and female) were tested. At PND 51, the animals' movements were video-recorded during an operant test procedure that lasted 90 min...
December 1, 2016: Behavioral and Brain Functions: BBF
https://www.readbyqxmd.com/read/27903520/visceral-adiposity-and-metabolic-syndrome-after-very-high-fat-and-low-fat-isocaloric-diets-a-randomized-controlled-trial
#4
Vivian L Veum, Johnny Laupsa-Borge, Øyvin Eng, Espen Rostrup, Terje H Larsen, Jan Erik Nordrehaug, Ottar K Nygård, Jørn V Sagen, Oddrun A Gudbrandsen, Simon N Dankel, Gunnar Mellgren
BACKGROUND: Different aspects of dietary pattern, including macronutrient and food profiles, may affect visceral fat mass and metabolic syndrome. OBJECTIVE: We hypothesized that consuming energy primarily from carbohydrate or fat in diets with similar food profiles would differentially affect the ability to reverse visceral adiposity and metabolic syndrome. DESIGN: Forty-six men (aged 30-50 y) with body mass index (in kg/m(2)) >29 and waist circumference >98 cm were randomly assigned to a very high-fat, low-carbohydrate (VHFLC; 73% of energy fat and 10% of energy carbohydrate) or low-fat, high-carbohydrate (LFHC; 30% of energy fat and 53% of energy carbohydrate) diet for 12 wk...
November 30, 2016: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27894557/reporting-helicopter-emergency-medical-services-in-major-incidents-a-delphi-study
#5
Sabina Fattah, Anne Siri Johnsen, Stephen J M Sollid, Torben Wisborg, Marius Rehn, Ákos Sóti, Anatolij Truhlář, Andreas J Krüger, Björn Gunnarsson, Dan Gryth, David Ohlén, Espen Fevang, Geir Arne Sunde, Ivo Breitenmoser, Jouni Kurola, Jouni Nurmi, Knut Fredriksen, Leif Rognås, Peter Temesvari, Søren Mikkelsen, Vidar Magnusson, Wolfgang Voelckel
OBJECTIVE: Research on helicopter emergency medical services (HEMS) in major incidents is predominately based on case descriptions reported in a heterogeneous fashion. Uniform data reported with a consensus-based template could facilitate the collection, analysis, and exchange of experiences. This type of database presently exists for major incident reporting at www.majorincidentreporting.net. This study aimed to develop a HEMS-specific major incident template. METHODS: This Delphi study included 17 prehospital critical care physicians with current or previous HEMS experience...
November 2016: Air Medical Journal
https://www.readbyqxmd.com/read/27887202/serological-markers-in-diagnosis-of-pediatric-inflammatory-bowel-disease-and-as-predictors-for-early-tumor-necrosis-factor-blocker-therapy
#6
Christine Olbjørn, Milada Cvancarova Småstuen, Espen Thiis-Evensen, Britt Nakstad, Morten Harald Vatn, Gøri Perminow
OBJECTIVE: To describe the prevalence of serological markers in newly diagnosed treatment-naïve pediatric inflammatory bowel disease (IBD), their utility in differentiating Crohn's disease (CD), ulcerative colitis (UC) and symptomatic non-IBD patients and whether serological markers are associated with early TNF blocker treatment. MATERIAL AND METHODS: Ninety-six children and adolescents <18 years, 58 with IBD and 38 symptomatic non-IBD controls were included...
November 25, 2016: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/27877183/time-resolved-investigation-of-molecular-components-involved-in-the-induction-of-formula-see-text-high-affinity-transport-system-in-maize-roots
#7
Youry Pii, Massimiliano Alessandrini, Luca Dall'Osto, Katia Guardini, Bhakti Prinsi, Luca Espen, Anita Zamboni, Zeno Varanini
The induction, i.e., the rapid increase of nitrate ([Formula: see text]) uptake following the exposure of roots to the anion, was studied integrating physiological and molecular levels in maize roots. Responses to [Formula: see text] treatment were characterized in terms of changes in [Formula: see text] uptake rate and plasma membrane (PM) H(+)-ATPase activity and related to transcriptional and protein profiles of NRT2, NRT3, and PM H(+)-ATPase gene families. The behavior of transcripts and proteins of ZmNRT2s and ZmNRT3s suggested that the regulation of the activity of inducible high-affinity transport system (iHATS) is mainly based on the transcriptional/translational modulation of the accessory protein ZmNRT3...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27866851/inhibition-of-the-glycolytic-activator-pfkfb3-in-endothelium-induces-tumor-vessel-normalization-impairs-metastasis-and-improves-chemotherapy
#8
Anna Rita Cantelmo, Lena-Christin Conradi, Aleksandra Brajic, Jermaine Goveia, Joanna Kalucka, Andreas Pircher, Pallavi Chaturvedi, Johanna Hol, Bernard Thienpont, Laure-Anne Teuwen, Sandra Schoors, Bram Boeckx, Joris Vriens, Anna Kuchnio, Koen Veys, Bert Cruys, Lise Finotto, Lucas Treps, Tor Espen Stav-Noraas, Francesco Bifari, Peter Stapor, Ilaria Decimo, Kim Kampen, Katrien De Bock, Guttorm Haraldsen, Luc Schoonjans, Ton Rabelink, Guy Eelen, Bart Ghesquière, Jalees Rehman, Diether Lambrechts, Asrar B Malik, Mieke Dewerchin, Peter Carmeliet
Abnormal tumor vessels promote metastasis and impair chemotherapy. Hence, tumor vessel normalization (TVN) is emerging as an anti-cancer treatment. Here, we show that tumor endothelial cells (ECs) have a hyper-glycolytic metabolism, shunting intermediates to nucleotide synthesis. EC haplo-deficiency or blockade of the glycolytic activator PFKFB3 did not affect tumor growth, but reduced cancer cell invasion, intravasation, and metastasis by normalizing tumor vessels, which improved vessel maturation and perfusion...
November 8, 2016: Cancer Cell
https://www.readbyqxmd.com/read/27864874/prognostic-biomarkers-and-surrogate-end-points-in-psc
#9
EDITORIAL
Mette Vesterhus, Espen Melum
No abstract text is available yet for this article.
December 2016: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/27863457/the-effects-of-high-resistance-few-repetitions-and-low-resistance-high-repetitions-resistance-training-on-climbing-performance
#10
Espen Hermans, Vidar Andersen, Atle Hole Saeterbakken
The aim of the study was to compare the effects of different strength training intensities on climbing performance, climbing-specific tests and a general strength test. Thirty lower grade and intermediate-level climbers participated in a 10-week training programme. The participants were randomized into three groups: high resistance-few repetitions training groups (HR-FR), low resistance-high repetitions training groups (LR-HR) and a control group (CON) which continued climbing/training as usual. Post-testing results demonstrated statistical tendencies for climbing performance improvements in the HR-FR and LR-HR (p = 0...
November 18, 2016: European Journal of Sport Science
https://www.readbyqxmd.com/read/27847949/the-hydrothermal-synthesis-crystal-structure-and-electrochemical-properties-of-mnsb2o4
#11
Martin Roelsgaard, Peter Nørby, Espen Eikeland, Martin Søndergaard, Bo Brummerstedt Iversen
Phase pure polycrystalline MnSb2O4 was synthesised under hydrothermal conditions. Impurities formed outside a narrow range of pH and metal stoichiometric ratios. The structure and its temperature dependence was studied based on multi-temperature conventional single crystal X-ray diffraction (SC-XRD) and high resolution synchrotron powder X-ray diffraction (PXRD). At low temperature (100-300 K) the lattice parameters expanded linearly with thermal expansion coefficients of αa,300 K = 8(1) × 10(-6) K(-1) and αc,300 K = 7...
November 16, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/27826628/perceptual-interference-processing-in-preschool-children-with-and-without-prenatal-exposure-to-selective-serotonin-reuptake-inhibitors
#12
Tone Kristine Hermansen, Santeri Yrttiaho, Espen Røysamb, Annika Melinder
BACKGROUND: Prenatal exposure to maternal depression, with or without maternal medical antidepressant treatment, may pose a risk to the child's cognitive and behavioral development. Targeting one of the core functions of behavioral regulation, we investigated both behavioral and neural indices of interference suppression in both exposed and control participants at preschool age. METHODS: Children (N = 80, M = 68.60 months, SD = 5.57) with prenatal exposure to maternal depression with (SSRI, N = 21) and without (DEP, N = 33) antidepressant treatment were tested together with unexposed children (CON, N = 26) on a behavioral flanker task while recording event-related potentials (ERPs)...
November 8, 2016: Psychopharmacology
https://www.readbyqxmd.com/read/27826606/resolution-of-calciphylaxis-after-urgent-kidney-transplantation-in-3-patients-with-end-stage-kidney-failure
#13
Espen Nordheim, Dag Olav Dahle, Ingrid Marie Syse, Anders Åsberg, Anna V Reisæter, Anders Hartmann
BACKGROUND: Calcific uremic arteriolopathy (CUA), also referred to as calciphylaxis, is a rare and serious complication of kidney failure with limited treatment options. Kidney transplantation (KTX) restores kidney function and is hence a potential treatment option for CUA. We present 3 patients who had their CUA lesions successfully healed after urgent KTX. METHODS: Data were retrospectively retrieved from hospital records at our national transplant center. RESULTS: All 3 patients had previously been kidney transplanted and had experienced graft loss and were in stage 5 kidney failure when CUA developed...
November 2016: Transplantation Direct
https://www.readbyqxmd.com/read/27809203/towards-atomistic-understanding-of-polymorphism-in-the-solvothermal-synthesis-of-zro2-nanoparticles
#14
Ann Christin Dippel, Kirsten M Ø Jensen, Christoffer Tyrsted, Martin Bremholm, Espen D Bøjesen, Dipankar Saha, Steinar Birgisson, Mogens Christensen, Simon J L Billinge, Bo B Iversen
Varying atomic short-range order is correlated with the ratio of the monoclinic (m) to tetragonal (t) phase in ZrO2 nanoparticle formation by solvothermal methods. Reactions from Zr oxynitrate in supercritical methanol and Zr acetate in water (hydrothermal route) were studied in situ by X-ray total scattering. Irrespective of the Zr source and solvent, the structure of the precursor in solution consists of edge-shared tetramer chains. Upon heating, the nearest-neighbor Zr-O and Zr-Zr distances shorten initially while the medium-range connectivity is broken...
November 1, 2016: Acta Crystallographica. Section A, Foundations and Advances
https://www.readbyqxmd.com/read/27808666/multimodal-therapy-is-feasible-in-elderly-anal-cancer-patients
#15
Jon Espen Dale, Sigrun Sebjørnsen, Sabine Leh, Cornelia Rösler, Stein Aaserud, Bjørn Møller, Øystein Fluge, Christian Erichsen, Saied Nadipour, Hartwig Kørner, Frank Pfeffer, Olav Dahl
BACKGROUND: Many patients are diagnosed with an anal cancer in high ages. We here present the outcome after oncological therapy for patients above 80 years compared with younger patients. MATERIALS AND METHODS: A series of 213 consecutive patients was diagnosed and treated at a single institution from 1984 to 2009. The patients received similar radiation doses but with different techniques, thus progressively sparing more normal tissues. The majority of patients also had simultaneous [5-fluorouracil (5FU) and mitomycin C] or induction chemotherapy (cisplatin and 5FU)...
November 3, 2016: Acta Oncologica
https://www.readbyqxmd.com/read/27807468/the-farseeing-real-world-fall-repository-a-large-scale-collaborative-database-to-collect-and-share-sensor-signals-from-real-world-falls
#16
Jochen Klenk, Lars Schwickert, Luca Palmerini, Sabato Mellone, Alan Bourke, Espen A F Ihlen, Ngaire Kerse, Klaus Hauer, Mirjam Pijnappels, Matthis Synofzik, Karin Srulijes, Walter Maetzler, Jorunn L Helbostad, Wiebren Zijlstra, Kamiar Aminian, Christopher Todd, Lorenzo Chiari, Clemens Becker
BACKGROUND: Real-world fall events objectively measured by body-worn sensors can improve the understanding of fall events in older people. However, these events are rare and hence challenging to capture. Therefore, the FARSEEING (FAll Repository for the design of Smart and sElf-adaptive Environments prolonging Independent livinG) consortium and associated partners started to build up a meta-database of real-world falls. RESULTS: Between January 2012 and December 2015 more than 300 real-world fall events have been recorded...
2016: European Review of Aging and Physical Activity
https://www.readbyqxmd.com/read/27797828/hybrid-scheme-for-modeling-local-field-potentials-from-point-neuron-networks
#17
Espen Hagen, David Dahmen, Maria L Stavrinou, Henrik Lindén, Tom Tetzlaff, Sacha J van Albada, Sonja Grün, Markus Diesmann, Gaute T Einevoll
With rapidly advancing multi-electrode recording technology, the local field potential (LFP) has again become a popular measure of neuronal activity in both research and clinical applications. Proper understanding of the LFP requires detailed mathematical modeling incorporating the anatomical and electrophysiological features of neurons near the recording electrode, as well as synaptic inputs from the entire network. Here we propose a hybrid modeling scheme combining efficient point-neuron network models with biophysical principles underlying LFP generation by real neurons...
October 20, 2016: Cerebral Cortex
https://www.readbyqxmd.com/read/27793853/investigating-the-extremes-of-the-continuum-of-paracrine-functions-in-cd34-cd31-cacs-across-diverse-populations
#18
Rian Q Landers-Ramos, Ryan M Sapp, Emily VandeWater, Jennifer Macko, Shawn Robinson, Yan Wang, Eva R Chin, Espen E Spangenburg, Steven J Prior, James M Hagberg
Paracrine function of circulating angiogenic cells (CACs) is thought to contribute to vascular maintenance. We previously identified S100A8 and S100A9 secreted from physically inactive individuals' CD34-/CD31+ CACs as negative regulators of capillary-like network formation. The purpose of this study was to further investigate the extremes of the continuum of CAC paracrine actions using two distinctly different groups representing "healthy" and "impaired" CAC function. We aimed to determine how capillary-like network formation in human umbilical vein endothelial cells (HUVECs) is affected by S100A8 and S100A9 in concentrations secreted by CACs from different ends of the health spectrum...
October 28, 2016: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/27793136/activation-of-innate-immune-genes-in-caprine-blood-leukocytes-after-systemic-endotoxin-challenge
#19
Øyvind Salvesen, Malin R Reiten, Peter M H Heegaard, Michael A Tranulis, Arild Espenes, Kerstin Skovgaard, Cecilie Ersdal
BACKGROUND: Sepsis is a serious health problem associated with a range of infectious diseases in animals and humans. Early events of this syndrome can be mimicked by experimental administration of lipopolysaccharides (LPS). Compared with mice, small ruminants and humans are highly sensitive to LPS, making goats valuable in inflammatory models. We performed a longitudinal study in eight Norwegian dairy goats that received LPS (0.1 μg/kg, Escherichia coli O26:B6) intravenously. A control group of five goats received corresponding volumes of sterile saline...
October 28, 2016: BMC Veterinary Research
https://www.readbyqxmd.com/read/27789385/nocebo-hyperalgesia-and-the-startle-response
#20
Per M Aslaksen, Ole Åsli, Morten Øvervoll, Espen Bjørkedal
BACKGROUND: The literature on the effects of nocebo on pain is sparse. The present experimental study investigated whether suggestions of nocebo hyperalgesia modified the startle response and whether increased startle contributed to the nocebo hyperalgesic effect. METHODS: A design with four groups was employed; the participants were randomized into either a placebo group, a natural history group, or into two nocebo groups. The participants in the placebo and nocebo groups received suggestions of pain decrease or pain increase, together with a placebo or nocebo cream applied to the lower arm, respectively...
December 17, 2016: Neuroscience
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