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JOURNAL ARTICLE
Hasan Çağın Lenk, Robert Løvsletten Smith, Kevin S O'Connell, Ole A Andreassen, Espen Molden
INTRODUCTION: Adequate antipsychotic treatment intensity is required before diagnosing resistant schizophrenia and initiating clozapine treatment. We aimed to investigate potential rapid drug metabolism underlying low dose-adjusted serum concentration (CD) of non-clozapine atypical antipsychotics preceding clozapine treatment. METHODS: Patients using non-clozapine, atypical antipsychotics (aripiprazole, risperidone, olanzapine, or quetiapine) within 1 year before starting clozapine were included in this study from a therapeutic drug monitoring service in Oslo, Norway, between 2005 and 2023...
April 18, 2024: CNS Drugs
#2
JOURNAL ARTICLE
Junjian Yu, Antai Yuan, Qi Liu, Wei Wang, Yuqi Sun, Zequn Li, Cheng Meng, Yanbing Zhou, Shougen Cao
BACKGROUND: Although current guidelines(ESPEN guideline: Clinical nutrition in surgery and other guidelines) recommend preoperative immunonutrition for cachectic gastric cancer patients, the strength of the recommendation is weak, and the level of evidence is low. The benefits of preoperative immunonutrition still remain controversial. PATIENTS AND METHODS: 112 patients with gastric cancer cachexia were enrolled in the study and randomly assigned in a 1:1 ratio to receive either preoperative enteral immunonutrition support (IN, n = 56) or standard enteral nutrition support (SEN, n = 56)...
April 17, 2024: World Journal of Surgical Oncology
#3
JOURNAL ARTICLE
Regina Cortes, Aina M Yañez, Laura Capitán-Moyano, Aina Millán-Pons, Miquel Bennasar-Veny
AIMS AND OBJECTIVES: To assess the prevalence of malnutrition in hospitalised adult patients, and to evaluate the accuracy of the most commonly used nutritional screening tools for identifying individuals at risk of malnutrition. METHODS: A prospective cross-sectional study was conducted on a total of 248 hospitalised patients in internal medicine wards (mean age: 75.2 years; 39.5% females). Nutritional screening was performed within 48 h of admission using the following tools: Malnutrition Universal Screening Tool (MUST), Nutrition Risk Screening Tool (NRS-2002), Malnutrition Screening Tool (MST), Short Nutritional Assessment Questionnaire (SNAQ), and Mini Nutritional Assessment Short Form (MNA-SF)...
April 17, 2024: Journal of Clinical Nursing
#4
JOURNAL ARTICLE
Hilde S Ørbo, Kristin H Bjørlykke, Joseph Sexton, Ingrid Jyssum, Anne T Tveter, Ingrid E Christensen, Siri Mjaaland, Tore K Kvien, Gunnveig Grødeland, Grete B Kro, Jørgen Jahnsen, Espen A Haavardsholm, Ludvig A Munthe, Sella A Provan, John T Vaage, Guro Løvik Goll, Kristin Kaasen Jørgensen, Silje Watterdal Syversen
OBJECTIVES: To assess incidence, severity and predictors of COVID-19, including protective post-vaccination levels of antibodies to the receptor-binding domain of SARS-CoV-2 spike protein (anti-RBD), informing further vaccine strategies for patients with immune-mediated inflammatory diseases (IMIDs) on immunosuppressive medication. METHODS: IMIDs on immunosuppressives and healthy controls (HC) receiving SARS-CoV-2 vaccines were included in this prospective observational study...
April 9, 2024: RMD Open
#5
JOURNAL ARTICLE
Casper S Poulsen, Dan Hesse, Gabriel R Fernandes, Tue H Hansen, Timo Kern, Allan Linneberg, Lore Van Espen, Torben Jørgensen, Trine Nielsen, Amra C Alibegovic, Jelle Matthijnssens, Oluf Pedersen, Henrik Vestergaard, Torben Hansen, Mette K Andersen
Latent autoimmune diabetes in adults (LADA) is a heterogeneous disease characterized by autoantibodies against insulin producing pancreatic beta cells and initial lack of need for insulin treatment. The aim of the present study was to investigate if individuals with LADA have an altered gut microbiota relative to non-diabetic control subjects, individuals with type 1 diabetes (T1D), and individuals with type 2 diabetes (T2D). Bacterial community profiling was performed with primers targeting the variable region 4 of the 16S rRNA gene and sequenced...
April 9, 2024: Scientific Reports
#6
JOURNAL ARTICLE
Ferda Sohret Kahveci, Kutay Demirkan, Mutlu Doganay, Ismail Gomceli, Kursat Gundogan, Arzu Topeli, Guzin Tumer, Mehmet Uyar, Osman Abbasoglu
OBJECTIVES: Medical nutrition therapy is one of the core components of patient management, although its implication is still limited in Daily practice globally. Clinicians are in need of guidance that will ease the application of medical nutrition therapy. The pre- and post-graduate curriculum for medical nutrition therapy is limited in most regions, worldwide. A report that is short, clear, and having clear-cut recommendations that will guide the primary healthcare professionals in indications, choice, practical application, follow-up, and stopping parenteral nutrition (PN) would facilitate the application and success of medical nutrition therapy...
March 20, 2024: Nutrition
#7
JOURNAL ARTICLE
Fredrik Strebel Skedsmo, Guro Løkka, Elvis Chikwati, Julianne Valla Jacobsen, Arild Espenes, Trond M Kortner
During recent years, there has been a renewed interest in establishing farming of Atlantic cod (Gadus morhua) in Norway. However, a fatal abdominal disorder compromises animal welfare and causes economic losses. A similar problem was present during a previous attempt to establish Atlantic cod farming more than a decade ago. In this paper, we provide the first in-depth description of this intestinal disorder, which is correctly denoted 'strangulating obstruction'. In affected fish, part of the intestine is permanently entrapped (incarcerated) under fibrous strands in the mesentery...
April 8, 2024: Journal of Fish Diseases
#8
Naz Karadag, Espen Hagen, Alexey A Shadrin, Dennis Van Der Meer, Kevin S O'Connell, Zillur Rahman, Gleda Kutrolli, Nadine Parker, Shahram Bahrami, Vera Fominykh, Kjell Heuser, Erik Tauboll, Torill Ueland, Nils Eiel Steen, Srdjan Djurovic, Anders M Dale, Oleksandr Frei, Ole A Andreassen, Olav B Smeland
Objective: Cognitive impairment is prevalent among individuals with epilepsy, and it is possible that genetic factors can underlie this relationship. Here, we investigated the potential shared genetic basis of common epilepsies and general cognitive ability (COG). Methods: We applied linkage disequilibrium score (LDSC) regression, MiXeR and conjunctional false discovery rate (conjFDR) to analyze different aspects of genetic overlap between COG and epilepsies. We used the largest available genome-wide association study data on COG ( n = 269,867) and common epilepsies ( n = 27,559 cases, 42,436 controls), including the broad phenotypes 'all epilepsy ', focal epilepsies and genetic generalized epilepsies (GGE), and as well as specific subtypes...
March 26, 2024: medRxiv
#9
JOURNAL ARTICLE
Kaja E Kjørholt, Nina Paulshus Sundlisæter, Anna-Birgitte Aga, Joseph Sexton, Inge C Olsen, Hallvard Fremstad, Cristina Spada, Tor Magne Madland, Christian A Høili, Gunnstein Bakland, Åse Lexberg, Inger Johanne Widding Hansen, Inger Myrnes Hansen, Hilde Haukeland, Maud-Kristine Aga Ljoså, Ellen Moholt, Till Uhlig, Tore K Kvien, Daniel H Solomon, Désirée van der Heijde, Espen A Haavardsholm, Siri Lillegraven
BACKGROUND: Tapering of disease-modifying antirheumatic drugs (DMARDs) to drug-free remission is an attractive treatment goal for patients with rheumatoid arthritis, although long-term effects of tapering and withdrawal remain unclear. We compared 3-year risks of flare between three conventional synthetic DMARD treatment strategies in patients with rheumatoid arthritis in sustained remission. METHODS: In this open-label, randomised controlled, non-inferiority trial, we enrolled patients aged 18-80 years with rheumatoid arthritis who had been in sustained remission for at least 1 year on stable conventional synthetic DMARD therapy...
April 4, 2024: Lancet Rheumatology
#10
JOURNAL ARTICLE
Espen Heen, Henrik Vogt
No abstract text is available yet for this article.
April 7, 2024: Journal of Evaluation in Clinical Practice
#11
JOURNAL ARTICLE
Regina Cortés-Aguilar, Narges Malih, Manuela Abbate, Sergio Fresneda, Aina Yañez, Miquel Bennasar-Veny
BACKGROUNDS & AIMS: Malnutrition is prevalent among hospitalized patients in developed countries, contributing to negative health outcomes and increased healthcare costs. Timely identification and management of malnutrition are crucial. The lack of a universally accepted definition and standardized diagnostic criteria for malnutrition has led to the development of various screening tools, each with varying validity. This complicates early identification of malnutrition, hindering effective intervention strategies...
March 15, 2024: Clinical Nutrition
#12
Henriette Røed-Undlien, Nina Haagenrud Schultz, Asbjørn Lunnan, Inger Marie Husebråten, Birgit Malene Wollmann, Espen Molden, Johannes Lagethon Bjørnstad
No abstract text is available yet for this article.
April 4, 2024: Journal of Cardiothoracic and Vascular Anesthesia
#13
RANDOMIZED CONTROLLED TRIAL
Violetta Dubovyk, Georgios K Vasileiadis, Tahzeeb Fatima, Yuan Zhang, Meliha Crnkic Kapetanovic, Alf Kastbom, Milad Rizk, Annika Söderbergh, Sizheng Steven Zhao, Ronald F van Vollenhoven, Merete Lund Hetland, Espen A Haavardsholm, Dan Nordström, Michael T Nurmohamed, Bjorn Gudbjornsson, Jon Lampa, Mikkel Østergaard, Marte Schrumpf Heiberg, Tuulikki Sokka-Isler, Gerdur Gröndal, Kristina Lend, Kim Hørslev-Petersen, Till Uhlig, Anna Rudin, Cristina Maglio
OBJECTIVE: This report from the NORD-STAR (Nordic Rheumatic Diseases Strategy Trials and Registries) trial aimed to determine if obesity is associated with response to conventional and biological antirheumatic treatment in early rheumatoid arthritis (RA). METHODS: This report included 793 participants with untreated early RA from the randomised, longitudinal NORD-STAR trial, all of whom had their body mass index (BMI) assessed at baseline. Obesity was defined as BMI ≥30 kg/m2 ...
April 4, 2024: RMD Open
#14
JOURNAL ARTICLE
Elena González Arnáiz, Diana Ariadel Cobo, Brisamar Estébanez, David Barajas Galindo, Begoña Pintor de la Maza, Ana Urioste Fondo, Carmen Dameto Pons, María J Cuevas, María D Ballesteros Pomar
BACKGROUND AND AIMS: Sarcopenic obesity (SO) is defined as a combination of low strength and muscle mass along with excess adiposity. Our study aimed to determine the prevalence of sarcopenic obesity in candidates for bariatric surgery, according to ESPEN/EASO criteria using bioimpedance analysis (BIA) and dual-energy X-ray absorptiometry (DXA). METHODS: Retrospective study of adult patients (18-60 years) candidates for bariatric surgery (BMI ≥40 kg/m2 or ≥35 kg/m2 with associated complications)...
April 1, 2024: Clinical Nutrition
#15
JOURNAL ARTICLE
Michelle E G Weijzen, Maxime Kohlen, Alejandra Monsegue, Dion C J Houtvast, Jean Nyakayiru, Sandra Beijer, Phil Geerlings, Lex B Verdijk, Luc J C van Loon
BACKGROUND & AIM: In hospitalized patients, daily protein intake remains far below WHO requirements for healthy adults (0.8 g·kg-1 ·d-1 ) as well as ESPEN guidelines for patients (1.2-1.5 g·kg-1 ·d-1 ). Providing access to a pre-sleep protein dense snack between dinner and going to bed may serve as a great opportunity to increase daily energy and protein intake in hospitalized patients. However, it remains to be assessed whether protein provision prior to sleep effectively increases protein intake, or may reduce food intake throughout the remainder of the day(s)...
March 28, 2024: Clinical Nutrition
#16
JOURNAL ARTICLE
Anders W Bjerring, Knut Hb Smeland, Thomas Stokke, Kristina H Haugaa, Espen Holte, Assami Rösner, Cecilie E Kiserud, Thor Edvardsen, Sebastian Imre Sarvari
BACKGROUND: Hodgkin's lymphoma (HL) is a hematological malignancy that affects both children and young adults. Traditional treatment is associated with a life-time prevalence of cardiac disease exceeding 50%. In the late 1990s protocols were modified to reduce cancer therapy-related adverse cardiac effects. This study aimed to assess the long-term impact of advances in treatment protocols on the cardiac health of HL survivors (HLS). METHODS: HLS (n = 246) treated between 1997 and 2007 with anthracycline-based chemotherapy in three centers in Norway were included...
April 4, 2024: Cardio-Oncology
#17
JOURNAL ARTICLE
Adrian Scutelnic, Anita van de Munckhof, Angel T Miraclin, Sanjith Aaron, Sajid Hameed, Mohammad Wasay, Oxana Grosu, Katarzyna Krzywicka, Mayte Sánchez van Kammen, Erik Lindgren, Tiago Moreira, Roberto Acampora, Alberto Negro, Theodoros Karapanayiotides, Shadi Yaghi, Anna Revert, Elisa Cuadrado Godia, Sebastian Garcia-Madrona, Paolino La Spina, Francesco Grillo, Fabrizio Giammello, Thanh N Nguyen, Mohamad Abdalkader, Alina Buture, Maria Sofia Cotelli, Nicolas Raposo, Georgios Tsivgoulis, Paolo Candelaresi, Antonio Ciacciarelli, Joshua Mbroh, Tatiana Batenkova, Pasquale Scoppettuolo, Marialuisa Zedde, Rosario Pascarella, Kateryna Antonenko, Espen S Kristoffersen, Johanna A Kremer Hovinga, Katarina Jood, Diana Aguiar de Sousa, Sven Poli, Turgut Tatlisumak, Jukka Putaala, Jonathan M Coutinho, José M Ferro, Marcel Arnold, Mirjam R Heldner
INTRODUCTION: Previous reports and meta-analyses derived from small case series reported a mortality rate of up to 40% in patients with coronavirus disease 2019 associated cerebral venous thrombosis (COVID-CVT). We assessed the clinical characteristics and outcomes in an international cohort of patients with COVID-CVT. PATIENTS AND METHODS: This was a registry study of consecutive COVID-CVT patients diagnosed between March 2020 and March 2023. Data collected by the International Cerebral Venous Thrombosis Consortium from patients with CVT diagnosed between 2017 and 2018 served as a comparison...
April 4, 2024: European Stroke Journal
#18
JOURNAL ARTICLE
Siri Christine Rødseth, Hedda Høvik, Espen Bjertness, Rasa Skudutyte-Rysstad
OBJECTIVES: To investigate socioeconomic inequality in caries experience in an adult Norwegian population. METHODS: This population-based study included 4549 dentate participants aged 25-94 years from the cross-sectional HUNT4 Oral Health Study conducted in Central Norway in 2017-2019. Participants were randomly sampled from the larger HUNT4 Survey and answered questionnaires and underwent clinical and radiographic examinations. Caries experience was measured as numbers of decayed, missing and filled teeth (DMFT index) and socioeconomic position was denoted by education and household income...
April 2, 2024: Community Dentistry and Oral Epidemiology
#19
JOURNAL ARTICLE
Benjamin Van Espen, E Barton Prideaux, Andrew R Wilson, Camilla R L Machado, Sho Sendo, James Parker, Grégory Seumois, Cristiano Sacchetti, Anna C Belongia, Narayanan B Perumal, Pandurangan Vijayanand, Matthew D Linnik, Robert J Benschop, Wei Wang, Nunzio Bottini, Gary S Firestein, Stephanie M Stanford
OBJECTIVE: Rheumatoid arthritis (RA) is an autoimmune disease in which the joint lining, or synovium, becomes highly inflamed and majorly contributes to disease progression. Understanding pathogenic processes in RA synovium is critical for identifying therapeutic targets. We performed laser capture microscopy (LCM) followed by RNA sequencing (LCM-RNAseq) to study regional transcriptomes throughout RA synovium. METHODS: Synovial lining, sublining, and vessels were captured by LCM from seven RA and seven osteoarthritis (OA) patients...
March 31, 2024: Arthritis & Rheumatology
#20
JOURNAL ARTICLE
Stig Ree Krüger, Espen Rigby Norvard, Kjersti Wik Larssen, Ursa Maierhofer, Helene Hestmann, Thomas Papathomas
No abstract text is available yet for this article.
March 29, 2024: International Journal of Infectious Diseases: IJID
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