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https://www.readbyqxmd.com/read/29788972/inequity-in-the-utilization-of-antenatal-and-delivery-care-in-yangon-region-myanmar-a-cross-sectional-study
#1
Aye Nyein Moe Myint, Tippawan Liabsuetrakul, Thein Thein Htay, Myint Myint Wai, Johanne Sundby, Espen Bjertness
BACKGROUND: Equity of access to and utilization of healthcare across socio-economic groups is important to achieve universal health coverage. Although the utilization of antenatal and delivery care has been increasing in low- and middle-income countries, inequities in the utilization of antenatal and delivery care have been reported in many countries, but have not yet been studied in Myanmar. This study aimed to determine whether inequities in the utilization of antenatal and delivery care existed in Yangon region, Myanmar...
May 22, 2018: International Journal for Equity in Health
https://www.readbyqxmd.com/read/29761156/viewpoint-and-practical-recommendations-from-a-movement-disorder-specialist-panel-on-objective-measurement-in-the-clinical-management-of-parkinson-s-disease
#2
REVIEW
Per Odin, K Ray Chaudhuri, Jens Volkmann, Angelo Antonini, Alexander Storch, Espen Dietrichs, Zvezdan Pirtošek, Tove Henriksen, Malcolm Horne, David Devos, Filip Bergquist
Motor aspects of Parkinson's disease, such as fluctuations and dyskinesia, can be reliably evaluated using a variety of "wearable" technologies, but practical guidance on objective measurement (OM) and the optimum use of these devices is lacking. Therefore, as a first step, a panel of movement disorder specialists met to provide guidance on how OM could be assessed and incorporated into clinical guidelines. A key aspect of the incorporation of OM into the management of Parkinson's disease (PD) is defining cutoff values that separate "controlled" from "uncontrolled" symptoms that can be modified by therapy and that relate to an outcome that is relevant to the person with PD (such as quality of life)...
2018: NPJ Parkinson's Disease
https://www.readbyqxmd.com/read/29758480/analytical-and-clinical-performance-of-progesterone-receptor-antibodies-in-breast-cancer
#3
Benjamin C Calhoun, Brian Mosteller, Daniel Warren, Margie Smith, J Jordi Rowe, Christopher P Lanigan, Karen C Mrazeck, Espen Walker, Amy Hanlon Newell, Raymond Jones
OBJECTIVE: Comparison of analytical and immunohistochemical performance of progesterone receptor (PR) antibodies with correlation to recurrence of invasive breast cancer treated with endocrine therapy. METHODS: The binding-affinity kinetics of PR clones 1E2, 1A6, 16 and 636 were compared using synthetic peptides derived from identified epitopes on a Biacore T200. A cohort of 351 cases (Hormone Receptor (HR)+/HER2-) were stained for PR expression with immunohistochemistry (IHC) and scored according to ASCO/CAP criteria...
February 27, 2018: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/29758007/characterization-of-rhamnolipids-produced-by-an-arctic-marine-bacterium-from-the-pseudomonas-fluorescence-group
#4
Venke Kristoffersen, Teppo Rämä, Johan Isaksson, Jeanette Hammer Andersen, William H Gerwick, Espen Hansen
The marine environment is a rich source of biodiversity, including microorganisms that have proven to be prolific producers of bioactive secondary metabolites. Arctic seas are less explored than warmer, more accessible areas, providing a promising starting point to search for novel bioactive compounds. In the present work, an Arctic marine Pseudomonas sp. belonging to the Pseudomonas (P.) fluorescence group was cultivated in four different media in an attempt to activate biosynthetic pathways leading to the production of antibacterial and anticancer compounds...
May 14, 2018: Marine Drugs
https://www.readbyqxmd.com/read/29751529/the-use-and-safety-of-tnf-inhibitors-during-pregnancy-in-women-with-psoriasis-a-review
#5
REVIEW
Cæcilie Bachdal Johansen, Espen Jimenez-Solem, Ann Haerskjold, Freja Lærke Sand, Simon Francis Thomsen
Psoriasis is a chronic immune-mediated inflammatory disease affecting women of childbearing potential. Biologic agents, notably Tumor Necrosis Factor inhibitors (TNFi), are the only current non-contraindicated systemic treatment option during pregnancy. TNFi comprised of complete immunoglobulin G (IgG) antibodies antibodies (adalimumab, golimumab, and infliximab) actively cross the placenta from the second trimester and are detectable in the child up to one year postpartum. Data on safety of TNFi are conflicting; however a trend towards drug-specific harm has been reported, with increased risk of congenital malformations and preterm birth...
May 3, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29750541/fatty-infiltration-is-a-prognostic-marker-of-muscle-function-after-rotator-cuff-tear
#6
Ana P Valencia, Jim K Lai, Shama R Iyer, Katherine L Mistretta, Espen E Spangenburg, Derik L Davis, Richard M Lovering, Mohit N Gilotra
BACKGROUND: Massive rotator cuff tears (RCTs) begin as primary tendon injuries and cause a myriad of changes in the muscle, including atrophy, fatty infiltration (FI), and fibrosis. However, it is unclear which changes are most closely associated with muscle function. PURPOSE: To determine if FI of the supraspinatus muscle after acute RCT relates to short-term changes in muscle function. STUDY DESIGN: Controlled laboratory study. METHODS: Unilateral RCTs were induced in female rabbits via tenotomy of the supraspinatus and infraspinatus...
May 1, 2018: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29749641/antioxidant-rich-foods-and-response-to-altitude-training-a-randomized-controlled-trial-in-elite-endurance-athletes
#7
Anu Elisa Koivisto, Gøran Paulsen, Ingvild Paur, Ina Garthe, Espen Tønnessen, Truls Raastad, Nasser Ezzatkhah Bastani, Jostein Hallén, Rune Blomhoff, Siv Kjølsrud Bøhn
High doses of isolated antioxidant supplements such as vitamin C and E, have demonstrated the potential to blunt cellular adaptations to training It is, however, unknown whether intake of high doses of antioxidants from foods has similar effects. Hence, the aim of the study was to investigate whether intake of antioxidant-rich foods affects adaptations to altitude training in elite athletes. In a randomized controlled trial, 31 national team endurance athletes (23 ± 5 years), ingested antioxidant-rich foods (n=16) or eucaloric control foods (n=15) daily during a 3-week altitude training camp (2320 m)...
May 11, 2018: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/29746011/medication-overuse-headache-detoxification-reduces-headache-disability-the-akershus-study-of-chronic-headache
#8
Espen Saxhaug Kristoffersen, Ragnhild Berling Grande, Kjersti Aaseth, Michael Bjørn Russell, Christofer Lundqvist
BACKGROUND: Medication-overuse headache (MOH) is a chronic headache (≥ 15 days/month) associated with overuse of acute headache medication. The objective was to investigate headache-related disability before and after self-detoxification from MOH in the general population, as well as possible predictors for successful outcome. METHODS: A prospective cohort study. Participants were identified in a cross-sectional epidemiological sample of 30 000 persons aged 30-44 from the general Norwegian population...
May 10, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29745739/training-performance-and-physiological-predictors-of-a-successful-elite-senior-career-in-junior-competitive-road-cyclists
#9
Ida S Svendsen, Espen Tønnesen, Leif Inge Tjelta, Stein Ørn
PURPOSE: to determine whether training, performance or physiological variables at age 18 can predict which athletes become World Tour (WT) riders at senior level. METHODS: Based on performance level age 23, 80 competitive male cyclists were retrospectively categorised into four groups: Retired (n=21), Club (n=26), Continental (n=24), or WT (n=9). Data collected at age 18 were analysed to determine whether training, performance or physiological variables differed significantly between groups...
May 10, 2018: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/29725741/-metabolic-management-and-nutrition-in-critically-ill-patients-with-renal-dysfunction-recommendations-from-the-renal-section-of-the-dgiin-%C3%A3-giain-and-divi
#10
W Druml, M Joannidis, S John, A Jörres, M Schmitz, J Kielstein, D Kindgen-Milles, M Oppert, V Schwenger, C Willam, A Zarbock
BACKGROUND: Intensive care patients with renal failure or insufficiency comprise a heterogeneous group of subjects with widely differing metabolic patterns and nutritional requirements. They include subjects with various stages of acute kidney injury (AKI), acute-on-chronic renal failure (A-CKD), without/with renal replacement therapy (RRT), chronic kidney disease (CKD), and subjects on regular hemodialysis or peritoneal dialysis therapy (HD/PD). GOALS: Development of recommendations by the renal section of DGIIN (Deutsche Gesellschaft für Internistische Intensivmedizin und Notfallmedizin), ÖGIAIN (Österreichische Gesellschaft für Internistische und Allgemeine Intensivmedizin und Notfallmedizin) and DIVI (Deutsche Interdisziplinäre Vereinigung für Intensiv- und Notfallmedizin) for the metabolic management and the planning, indication, implementation, and monitoring of nutrition therapy in this heterogeneous group of patients...
May 3, 2018: Medizinische Klinik, Intensivmedizin und Notfallmedizin
https://www.readbyqxmd.com/read/29679922/the-reliability-of-gait-variability-measures-for-individuals-with-parkinson-s-disease-and-healthy-older-adults-the-effect-of-gait-speed
#11
Linda Rennie, Niklas Löfgren, Rolf Moe-Nilssen, Arve Opheim, Espen Dietrichs, Erika Franzén
BACKGROUND: Step-to-step variability is a marker of reduced motor control and a frequently studied outcome measure in neurodegenerative disorders such as Parkinson's disease (PD) as compared to healthy older adults (HOA). To challenge motor control of gait, walking should be tested at different gait speeds. Good reliability is essential, and gait variability estimates show good reproducibility when sampled at normal gait speed. The aim was therefore to investigate if gait variability could be reliably sampled at slow and fast speeds for individuals with PD and HOA by evaluating test-retest reliability...
April 14, 2018: Gait & Posture
https://www.readbyqxmd.com/read/29677387/il13r%C3%AE-2-expression-identifies-tissue-resident-il-22-producing-plzf-innate-t-cells-in-the-human-liver
#12
Dominic Paquin-Proulx, Benjamin C Greenspun, Lise Pasquet, Benedikt Strunz, Soo Aleman, Karolin Falconer, Masaki Terabe, Jay A Berzofsky, Johan K Sandberg, Espen Melum, Douglas F Nixon, Niklas K Björkström
Innate lymphocytes are selectively enriched in the liver where they have important roles in liver immunology. Murine studies have shown that type I NKT cells can promote liver inflammation whereas type II NKT cells have an anti-inflammatory role. In humans, type II NKT cells were found to accumulate in the gut during inflammation and IL13Rα2 was proposed as a marker for these cells. In the human liver, less is known about type I and II NKT cells. Here, we studied the phenotype and function of human liver T cells expressing IL13Rα2...
April 20, 2018: European Journal of Immunology
https://www.readbyqxmd.com/read/29665848/characterization-and-utilization-of-the-flexor-digitorum-brevis-for-assessing-skeletal-muscle-function
#13
Michael D Tarpey, Adam J Amorese, Nicholas P Balestrieri, Terence E Ryan, Cameron A Schmidt, Joseph M McClung, Espen E Spangenburg
BACKGROUND: The ability to assess skeletal muscle function and delineate regulatory mechanisms is essential to uncovering therapeutic approaches that preserve functional independence in a disease state. Skeletal muscle provides distinct experimental challenges due to inherent differences across muscle groups, including fiber type and size that may limit experimental approaches. The flexor digitorum brevis (FDB) possesses numerous properties that offer the investigator a high degree of experimental flexibility to address specific hypotheses...
April 17, 2018: Skeletal Muscle
https://www.readbyqxmd.com/read/29663756/serumkonsentrasjonsm%C3%A3-linger-av-doak-legemidler
#14
Roar Dyrkorn, Halvor Lundgaard, Charlotte Lorentze Stokes, Espen Molden, Olav Spigset
No abstract text is available yet for this article.
April 17, 2018: Tidsskrift for Den Norske Lægeforening: Tidsskrift for Praktisk Medicin, Ny Række
https://www.readbyqxmd.com/read/29661152/genetic-variability-in-the-sdrd-gene-in-staphylococcus-aureus-from-healthy-nasal-carriers
#15
Clement Ajayi, Espen Åberg, Fatemeh Askarian, Johanna U E Sollid, Mona Johannessen, Anne-Merethe Hanssen
BACKGROUND: Staphylococcus aureus cell wall anchored Serine Aspartate repeat containing protein D (SdrD) is a member of the microbial surface component recognising adhesive matrix molecules (MSCRAMMs). It is involved in the bacterial adhesion and virulence. However the extent of genetic variation in S. aureus sdrD gene within isolates from healthy carriers are not known. The aim of this study was to evaluate allelic variation of the sdrD gene among S. aureus from healthy nasal carriers...
April 16, 2018: BMC Microbiology
https://www.readbyqxmd.com/read/29649093/comparison-of-cyp3a4-inducing-capacity-of-enzyme-inducing-antiepileptic-drugs-using-4%C3%AE-hydroxycholesterol-as-biomarker
#16
Kristine Hole, Birgit M Wollmann, Camilla Nguyen, Tore Haslemo, Espen Molden
BACKGROUND: Enzyme-inducing antiepileptic drugs (EIAEDs) are among the clinically most important inducers of cytochrome P450 (CYP) 3A4, but there is limited evidence regarding the comparative potency of each EIAED in raising CYP3A4 activity. The aim of this study was to estimate CYP3A4-inductive potency of EIAEDs by comparing CYP3A4 activity in patients treated with carbamazepine, phenobarbital, or phenytoin. METHODS: Residual serum samples from patients treated with EIAEDs or levetiracetam were collected from a therapeutic drug monitoring service for analysis of 4β-hydroxycholesterol (4βOHC), which is an indicator of CYP3A4 activity...
April 11, 2018: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/29644603/assessment-of-intake-of-copper-and-lead-by-sheep-grazing-on-a-shooting-range-for-small-arms-a-case-study
#17
Ida Vaa Johnsen, Espen Mariussen, Øyvind Voie
The Norwegian Armed Forces' shooting ranges contain contamination by metals such as lead (Pb) and copper (Cu) and are often used as grazing pastures for livestock. To determine whether the sheep were at risk from grazing at a shooting range in Nord-Trøndelag (the Leksdalen shooting field), a study was conducted wherein the aim was to determine the amount of soil the sheep were eating, the accumulation of Cu and Pb in the livers of lambs grazing on the shooting ranges, and the accumulation of Pb and Cu in the grass...
April 11, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29629599/remission-of-chronic-headache-an-11-year-follow-up-study-data-from-the-nord-tr%C3%A3-ndelag-health-surveys-1995-1997-and-2006-2008
#18
Knut Hagen, Espen Saxhaug Kristoffersen, Bendik Slagvold Winsvold, Lars Jacob Stovner, John-Anker Zwart
Objectives To estimate remission rates of chronic headache and predictors of remission. Methods In this longitudinal population-based cohort study, we used validated headache questionnaire data from the second (1995-1997, baseline; n = 51,856 aged ≥ 20 years, response rate: 55%) and third wave (2006-2008, follow-up, response rate: 42%) of the Nord-Trøndelag Health Study. Chronic headache was defined as ≥15 headache days/month during the last year. Chronic headache remission was defined as headache less than 15 days/month at follow-up...
January 1, 2018: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/29614838/molecular-and-antigenic-characterization-of-piscine-orthoreovirus-prv-from-rainbow-trout-oncorhynchus-mykiss
#19
Kannimuthu Dhamotharan, Niccolò Vendramin, Turhan Markussen, Øystein Wessel, Argelia Cuenca, Ingvild B Nyman, Anne Berit Olsen, Torstein Tengs, Maria Krudtaa Dahle, Espen Rimstad
Piscine orthoreovirus (PRV-1) causes heart and skeletal muscle inflammation (HSMI) in farmed Atlantic salmon ( Salmo salar ). Recently, a novel PRV (formerly PRV-Om, here called PRV-3), was found in rainbow trout ( Oncorhynchus mykiss ) with HSMI-like disease. PRV is considered to be an emerging pathogen in farmed salmonids. In this study, molecular and antigenic characterization of PRV-3 was performed. Erythrocytes are the main target cells for PRV, and blood samples that were collected from experimentally challenged fish were used as source of virus...
April 2, 2018: Viruses
https://www.readbyqxmd.com/read/29609612/association-between-age-and-outpatient-clinic-arrival-time-myth-or-reality
#20
Kashif Waqar Faiz, Espen Saxhaug Kristoffersen
BACKGROUND: Non-attendance and late arrivals diminish patient flow in outpatient clinics. On the other hand, patient earliness may also be undesirable. Physicians often experience that older patients are more punctual than younger patients, and often they come excessively early. The aim of this study was to determine whether an association between age and outpatient clinic arrival time could be established or not, i.e. to find out if it is a myth or a reality. METHODS: Prospective descriptive study performed at a neurological outpatient clinic...
April 2, 2018: BMC Health Services Research
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