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angiopathy predict ultrasound

Michael Allon, Michelle L Robbin, Heidi R Umphrey, Carlton J Young, Mark H Deierhoi, Jeremy Goodman, Michael Hanaway, Mark E Lockhart, Jill Barker-Finkel, Silvio Litovsky
BACKGROUND: Arteriovenous fistulas (AVFs) often fail to mature, but the mechanism of AVF nonmaturation is poorly understood. Arterial microcalcification is common in patients with chronic kidney disease (CKD) and may limit vascular dilatation, thereby contributing to early postoperative juxta-anastomotic AVF stenosis and impaired AVF maturation. This study evaluated whether preexisting arterial microcalcification adversely affects AVF outcomes. STUDY DESIGN: Prospective study...
July 2015: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
E DeVallance, S B Fournier, D A Donley, D E Bonner, K Lee, J C Frisbee, P D Chantler
INTRODUCTION: Obesity is thought to exert detrimental effects on the cardiovascular (CV) system. However, this relationship is impacted by the co-occurrence of CV risk factors, type 2 diabetes (T2DM) and overt disease. We examined the relationships between obesity, assessed by body mass index (BMI) and waist circumference (WC), and CV function in 102 subjects without overt CV disease. We hypothesized that obesity would be independently predictive of CV remodeling and functional differences, especially at peak exercise...
February 2015: International Journal of Obesity: Journal of the International Association for the Study of Obesity
Chuang Yuan, Christopher W K Lai, Lawrence W C Chan, Meyrick Chow, Helen K W Law, Michael Ying
AIMS. The aim of this study is to determine the extent of carotid atherosclerosis in Chinese patients with type 2 diabetes in relation to the cumulative atherosclerosis risk factors using ultrasonography. METHODS. The presence of hypertension, dyslipidemia, and chronic kidney disease (CKD) was documented in 106 Chinese subjects with type 2 diabetes. Subjects with 0, 1, and ≥2 additional atherosclerosis risk factors were assigned into groups 1, 2, and 3, respectively (n = 17, 49, and 40, resp.). Using ultrasound, the carotid arteries were assessed for the presence of carotid plaque, plaque score, intima-media thickness (IMT), and carotid arterial stiffness...
2014: Journal of Diabetes Research
Jovana Nikolajevic Starcevic, Marija Santl Letonja, Zala J Praznikar, Jana Makuc, Andreja C Vujkovac, Daniel Petrovic
BACKGROUND: Apolipoprotein B is a key structural component of all the atherogenic lipoproteins (LDL, VLDL and IDL). Genetic variations of the ApoB gene may affect plasma ApoB and lipid levels, thus influencing atherogenesis. The present study was designed to investigate the association of polymorphisms XbaI (rs693) and EcoRI (rs1042031) of the ApoB gene with plasma ApoB level, lipid levels and the different ultrasound phenotypes of carotid atherosclerosis in patients with diabetes mellitus type 2...
May 2014: VASA. Zeitschrift Für Gefässkrankheiten
Peter Holmquist, Petru Liuba
BACKGROUND: Renal disease remains a serious threat in patients with insulin-dependent (type1) diabetes. Hence its detection early in the life of patients with type1 diabetes is crucial. Several lines of evidence suggest similar mechanisms for the development of both renal and arterial disease. We sought to investigate in young patients with type1 diabetes whether π-Glutathione S-transferase to creatinine (π-GST:crea) and Tamm-Horsfall protein to creatinine (THP:crea) ratios, markers of distal tubular renal function, relate to subclinical markers of arterial disease, which appear to onset early and develop rapidly in type1 diabetes...
2014: BMC Cardiovascular Disorders
Lisbeth Antonsen, Michael Maeng, Per Thayssen, Evald Høj Christiansen, Knud Nørregaard Hansen, Anne Kaltoft, Henrik Steen Hansen, Leif Thuesen, Jens Flensted Lassen, Lisette Okkels Jensen
OBJECTIVE: To evaluate the effects of the everolimus-eluting Xience™/Promus™ stent (EES) and the sirolimus-eluting Cypher™ stent (SES) on intimal hyperplasia (IH) in diabetic patients. BACKGROUND: Patients with diabetes mellitus have increased risk of in-stent restenosis after coronary stent implantation due to intimal hyperplasia (IH). METHODS: In a sub study of the Randomized Comparison of Everolimus-Eluting and Sirolimus-Eluting Stents in Patients Treated with Percutaneous Coronary Intervention (SORT OUT IV trial), serial intravascular ultrasound (IVUS) 10-month follow-up data were available in 88 patients, including 48 EES and 40 SES treated patients...
May 1, 2014: Catheterization and Cardiovascular Interventions
Sylvia Otto, Maria Seeber, Buntaro Fujita, Daniel Kretzschmar, Markus Ferrari, Bjoern Goebel, Hans R Figulla, Tudor C Poerner
Elevation of cardiac troponin I (cTnI) is a well-known complication after percutaneous coronary interventions (PCI). The aims of this study were to quantify the extent of coronary microembolization during elective PCI, to identify predisposing anatomical and procedural factors, and to evaluate its impact on long-term outcome in diabetic patients with a high cardiovascular risk. 48 patients (pts, median 66.7 years) with type 2 diabetes and coronary artery disease underwent elective PCI with stenting to treat single-vessel lesions...
September 2012: Basic Research in Cardiology
Xavier Martí, Antoni Romera, Ramon Vila, Marc A Cairols
BACKGROUND: To assess the role of ultrasound arterial mapping in planning therapeutic options for critical limb ischemia (CLI) in diabetic patients. METHODS: This observational and comparative study included 244 patients with CLI. All participants (64% were diabetic) underwent ultrasound arterial mapping before planning surgical treatment. We established two groups: diabetic (n = 156) and nondiabetic (n = 88). Arterial mapping was divided into segments. We studied 2,021 individual segments and used arteriography when ultrasound arterial mapping was not conclusive...
November 2012: Annals of Vascular Surgery
Hirofumi Tomiyama, Takahide Kohro, Yukihito Higashi, Bonpei Takase, Toru Suzuki, Tomoko Ishizu, Shinichiro Ueda, Tsutomu Yamazaki, Tomoo Furumoto, Kazuomi Kario, Teruo Inoue, Shinji Koba, Kentaro Watanabe, Yasuhiko Takemoto, Takuzo Hano, Masataka Sata, Yutaka Ishibashi, Koichi Node, Koji Maemura, Yusuke Ohya, Taiji Furukawa, Hiroshi Ito, Akira Yamashina
Flow-mediated vasodilatation of the brachial artery (FMD) is a marker which is related to endothelial nitric oxide bioavailability. Commercially available ultrasound machines equipped with online computer-assisted semi-automatic analysis software to measure FMD have recently become available in Japan. These devices enable more convenient examination, enhanced reproducibility of FMD measurement, and a shortened examination time. Using such devices, in the present multicenter prospective study we propose to: 1) establish standardized FMD values and determine the annual rates of FMD change in healthy subjects; 2) confirm the predictive value of FMD for future cardiovascular events in Japanese subjects; 3) evaluate the potential usefulness of a multimarker strategy, including measurements of FMD, pulse-wave velocity (PWV), ankle-brachial pressure index, biochemical markers, and proteomic biomarkers obtained by mass spectroscopic analysis to assess the prognosis of subjects with coronary artery disease; and 4) clarify the usefulness of FMD measurement to predict the rate of progression of carotid atherosclerosis, arterial stiffness and microalbuminuria in subjects with hypertension or diabetes mellitus...
2012: International Heart Journal
Yusuf Unal Sarikabadayi, Ozge Aydemir, Gozde Kanmaz, Cumhur Aydemir, Serife Suna Oguz, Omer Erdeve, Elif Gul Yapar Eyi, Sema Zergeroglu, Ugur Dilmen
BACKGROUND: Large for gestational age (LAG) neonates who had been exposed to an intrauterine environment of either diabetes or maternal obesity are at increased risk of developing the metabolic syndrome. This can be explained by exposure to high glucose and insulin levels in utero which alter fetal adaptation and programming. OBJECTIVES: The aim of the study was to evaluate the onset of preclinical atherosclerosis in utero. METHODS: We measured umbilical artery wall thickness (ruWT) in the third trimester by obstetric ultrasound and umbilical artery intima-media thickness (uIMT) in pathologic specimens of umbilical cords obtained shortly after delivery and investigated the relation between these measurements and serum insulin level and C-peptide level in cord blood and assessed insulin resistance with the homeostasis model assessment of insulin resistance (HOMA-IR) in infants of diabetic mothers (IDMs), i...
2012: Neonatology
Zhiyong Yin, Linni Fan, Hongbing Jia, Congye Li, Rongqing Zhang, Haichang Wang
The prevalence of diabetes is rising rapidly throughout the world, accompanying with the increased occurrence of cardiovascular diseases in clinic. For now, the diagnosis of diabetic cardiovascular diseases has mainly based on the measurement of glucose levels in blood and cardiac function via electrocardiogram and ultrasound cardiogram. However, growing evidence strongly suggests that the assessment of Sphingosine-1-phosphate receptor 1/3 (S1P1/3) own advantages over present measurements in predicting the risk of developing diabetic cardiovascular diseases...
August 2012: Medical Hypotheses
Bo Zhao, Yanping Liu, Yifei Zhang, Yuhong Chen, Zhifang Yang, Ying Zhu, Weiwei Zhan
BACKGROUND: Different population studies have reported gender difference in carotid intima-media thickness (CIMT), which is proved to be a risk factor of cardiovascular diseases. However, few longitudinal researches examine this gender difference in type 2 diabetes mellitus (T2DM) patients. Therefore, we prospectively analyzed CIMT in T2DM patients over a 4-year follow-up period. METHODS: 355 T2DM patients (mean age 59 years; 54.9% women) were included in the present study...
2012: Cardiovascular Diabetology
Ana Laynez, Gabriel Sardi, Camille Hauville, Israel M Barbash, Rajbabu Pakala, Rebecca Torguson, Zhenyi Xue, Lowell F Satler, Augusto D Pichard, Ron Waksman
OBJECTIVES: This study aimed to analyze the use of everolimus-eluting stents (EES) and paclitaxel-eluting stents (PES) in an unrestricted diabetic population and to compare the performance of these two drug-eluting stents. BACKGROUND: EES have demonstrated superiority in efficacy when compared to PES in a general population. However, it is controversial whether this superiority holds true in a diabetic population. METHODS: From March 2004 to May 2010, 968 patients with consecutive diabetes who underwent percutaneous coronary intervention and implantation of an EES (n = 388) or PES (n = 580) at our institution...
April 2013: Catheterization and Cardiovascular Interventions
Yu Kataoka, Mingyuan Shao, Kathy Wolski, Kiyoko Uno, Rishi Puri, E Murat Tuzcu, Steven E Nissen, Stephen J Nicholls
BACKGROUND: Diabetic patients with coronary artery disease (CAD) demonstrate accelerated progression of coronary atherosclerosis. The impact of multiple risk factor intervention on disease progression has not been investigated. DESIGN: We investigated 448 diabetic patients with angiographic CAD who underwent serial intravascular ultrasound imaging to monitor the change in atheroma burden in seven clinical trials. METHODS: Disease progression was compared in patients stratified according to whether they achieved increasing numbers of treatment goals of individual risk factors (HbA1c <7...
April 2013: European Journal of Preventive Cardiology
Naoya Kawano, Masanori Emoto, Katsuhito Mori, Yuko Yamazaki, Hiromi Urata, Shoko Tsuchikura, Koka Motoyama, Tomoaki Morioka, Shinya Fukumoto, Tetsuo Shoji, Hidenori Koyama, Yasuhisa Okuno, Yoshiki Nishizawa, Masaaki Inaba
AIM: Atherosclerosis and arteriosclerosis are mainly caused by the dysfunction of arterial components, namely, vascular endothelial cells, smooth muscle cells, and the extracellular matrix. Endothelial dysfunction is well established as a predictive surrogate marker of cardiovascular events; however, little is known regarding the clinical implications of vascular smooth muscle dysfunction for cardiovascular disease and microangiopathy. In the present study, we aimed to clarify the association of arterial dysfunction with micro-/macroangiopathy and conventional cardiovascular risk factors in 181 type 2 diabetic patients (T2DM; age ± SD, 64 ± 10 years; duration of diabetes, 12 ± 10 years)...
2012: Journal of Atherosclerosis and Thrombosis
Michael S Conte, Helen M Nugent, Peter Gaccione, Prabir Roy-Chaudhury, Jeffrey H Lawson
OBJECTIVES: Arteriovenous fistula (AVF) is the preferred type of vascular access for hemodialysis to treat end-stage renal disease. A high proportion of AVF are never used for dialysis because the vein fails to mature adequately. We have previously described the safety and feasibility of Vascugel (Genzyme BioSurgery, Cambridge, Mass) (allogeneic aortic endothelial cells in a gelatin matrix) when placed around the anastomotic and venous outflow sites of AVFs (Vascular intimal Hyperplasia: Extending Arterial and venous patency, Limiting vascular Trauma, and inhibiting Hyperplasia while re-establishing vascular health [V-HEALTH] clinical study)...
November 2011: Journal of Vascular Surgery
B Nussbaumerová, H Rosolová, J Ferda, P Sifalda, I Sípová, F Sefrna
INTRODUCTION: The ankle brachial index (ABI), i.e. the ratio of systolic blood pressure (SBP) on the ankle and on the arm, is diagnostic for peripheral occlusive artery disease and a marker of cardiovascular (CV) risk. The association between the low ABI < 0.9 and the CV risk in type 2 diabetes (T2DM) subjects was investigated. METHODS: We examined 253 T2DM subjects (135 males, 118 females, aged 66 +/- 9 years). The blood pressures were measured in the supine position with the 2 mm Hg accuracy; Doppler ultrasound was used for the ankle SBP and the mercury sphygnomanometer for the arm SBP...
March 2011: Vnitr̆ní Lékar̆ství
Héctor M García-García, Scot Garg, Salvatore Brugaletta, Giorgio Morocutti, Robert E Ratner, Nikheel S Kolatkar, Barbara G Kravitz, Diane M Miller, Chun Huang, Richard W Nesto, Patrick W Serruys
To determine (1) the medium-term effect of rosiglitazone and glipizide on intra-stent neointima hyperplasia, (2) restenosis pattern as assessed by intra-vascular ultrasound (IVUS) and quantitative coronary angiography (QCA) in patients with T2DM and coronary artery disease. A total of 462 patients with T2DM were randomized to rosiglitazone or glipizide for up to 18 months in the APPROACH trial, and had evaluable baseline and follow-up IVUS examinations. There was no significant difference in the size of plaque behind stent between the rosiglitazone and glipizide groups at 18 months among those treated with a bare metal stent (-5...
March 2012: International Journal of Cardiovascular Imaging
Charles A Andersen
The timely and accurate noninvasive assessment of peripheral arterial disease (PAD) is a critical component of a limb preservation initiative in patients with diabetes mellitus. Noninvasive vascular studies (NIVS) can be useful in screening patients with diabetes for PAD. In patients with clinical signs or symptoms, NIVS provide crucial information on the presence, location, and severity of PAD, as well as an objective assessment of the potential for primary healing of an index wound or a surgical incision...
September 2010: Journal of Vascular Surgery
Giovanni Targher, Lorenzo Bertolini, Roberto Padovani, Stefano Rodella, Giacomo Zoppini, Isabella Pichiri, Claudia Sorgato, Luciano Zenari, Enzo Bonora
BACKGROUND & AIMS: To estimate the prevalence of non-alcoholic fatty liver disease (NAFLD) in type 1 diabetic individuals, and to evaluate whether NAFLD is associated with increased prevalence of cardiovascular disease (CVD). METHODS: All patients with diagnosed type 1 diabetes with available liver ultrasound data (n=250), who regularly attended our diabetes clinic, were enrolled. Main study measures were detection of NAFLD (by patient history and liver ultrasound) and asymptomatic/symptomatic CVD (by patient history, chart review, electrocardiogram, and echo-Doppler scanning of carotid and lower limb arteries)...
October 2010: Journal of Hepatology
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