Alexander C Razavi, Leslee J Shaw, Daniel S Berman, Matthew J Budoff, Nathan D Wong, Viola Vaccarino, Marly van Assen, Carlo N De Cecco, Arshed A Quyyumi, Anurag Mehta, Paul Muntner, Michael D Miedema, Alan Rozanski, John A Rumberger, Khurram Nasir, Roger S Blumenthal, Laurence S Sperling, Martin Bødtker Mortensen, Seamus P Whelton, Michael J Blaha, Omar Dzaye
BACKGROUND: Although a coronary artery calcium (CAC) of ≥1,000 is a subclinical atherosclerosis threshold to consider combination lipid-lowering therapy, differentiating very high from high atherosclerotic cardiovascular disease (ASCVD) risk in this patient population is not well-defined. OBJECTIVES: Among persons with a CAC of ≥1,000, the authors sought to identify risk factors equating with very high-risk ASCVD mortality rates. METHODS: The authors studied 2,246 asymptomatic patients with a CAC of ≥1,000 from the CAC Consortium without a prior ASCVD event...
February 12, 2024: JACC. Cardiovascular Imaging