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Cancer causes prevention

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https://www.readbyqxmd.com/read/29932372/fibrin-patch-influences-the-expression-of-hypoxia-inducible-factor-1%C3%AE-and-nuclear-factor-%C3%AE%C2%BAbp65-factors-on-ischemic-intestinal-anastomosis
#1
Carlos García-Vásquez, María J Fernández-Aceñero, Soledad García Gómez-Heras, Carlos Pastor
The intestinal anastomotic failure is one of the most severe complications in gastrointestinal surgery. Despite the great surgical improvements during the last decade, anastomotic leak rates remain practically the same, with a dramatically high grade of morbidity for patients. Leakages are usually the final consequence of ischemia in the anastomosis, leading to tissue hypoxia. In response to hypoxia, the cell orchestrates a variety of coordinated responses in order to restore oxygen homeostasis. The molecular mechanism of hypoxia sensitivity involves oxygen sensing hydroxylases, prolyl-hydroxylases, orchestrating two main transcription factors related to induction of inflammation and angiogenesis, namely nuclear factor-κB and hypoxia-inducible factors...
June 2018: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29931492/histopathologic-and-molecular-comparative-analyses-of-intravesical-aurora-kinase-a-inhibitor-alisertib-with-bacillus-calmette-gu%C3%A3-rin-on-precancerous-lesions-of-bladder-in-a-rat-model
#2
Kerem Teke, Hasan Yilmaz, Ali Kemal Uslubas, Gurler Akpinar, Murat Kasap, Oguz Mutlu, Demir Kursat Yildiz, Nil Guzel, Ozdal Dillioglugil
PURPOSE: Recent studies have shown that Aurora-A expression is associated with bladder cancer initiation and progression. In this study, the effects of intravesical Aurora-A inhibitor Alisertib (ALS) and bacillus Calmette-Guérin (BCG) were compared on bladder carcinogenesis. METHODS: Two mg N-Methyl-N-nitrosourea was administered intravesically to forty of Wistar-albino rats every other week for 8 weeks. At week 10, rats were divided into four groups (10/group): No-treatment (vehicle), ALS-alone, BCG-alone, and ALS + BCG...
June 21, 2018: International Urology and Nephrology
https://www.readbyqxmd.com/read/29930928/prevalence-of-fungemia-in-pediatric-patients-with-febrile-neutropenia
#3
Mohsen Meidani, Masoome Baniasadi, Farzin Khorvash
Background: Increasing use of different chemotherapy regimens, organ transplants, etc., has led to the increasing number of neutropenic patients. Overall, 10% of patients affected by cancer who are under treatment with anticancer drugs, regardless of the tumor type, are susceptible to febrile neutropenia. The study was performed to evaluate the frequency of bloodstream fungal infections in pediatric patients with febrile neutropenia in Sayed Al-Shohada Hospital (Cancer Referral Center in Isfahan) in 2010-2012...
2018: Advanced Biomedical Research
https://www.readbyqxmd.com/read/29930482/integrin-%C3%AE-1-regulates-the-invasion-and-radioresistance-of-laryngeal-cancer-cells-by-targeting-cd147
#4
Li Li, Xiaoxia Dong, Feng Peng, Li Shen
Background: Increased expression of integrin β1 has been reported to correlate with progression and therapy resistance in many types of cancers. The aim of this study was to investigate the effects of integrin β1 on the invasion and radioresistance of laryngeal cancer cells. Methods: The expression of integrin β1 in the tumor specimens of laryngeal cancer patients was assessed by immunohistochemical assays. The invasion ability of laryngeal cancer cells was detected by transwell and wound healing assays...
2018: Cancer Cell International
https://www.readbyqxmd.com/read/29926432/using-film-to-disseminate-information-on-cervical-cancer-prevention-in-lusaka-results-from-a-small-intervention-study
#5
Anayawa Nyambe, Jarl K Kampen, Stridutt K Baboo, Guido Van Hal
In order to prevent the spread of cervical cancer, people must be aware and knowledgeable about the available preventive practices such as screening and vaccination. The purpose of this study was to determine the extent that film is effective in disseminating information on cervical cancer and its prevention to women and men in Lusaka. A pilot intervention study was carried out at churches in Lusaka city from August to September 2017. A sample size of 38 women and 43 men filled in both baseline and follow-up questionnaires...
June 20, 2018: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://www.readbyqxmd.com/read/29925295/a-case-report-pharmacology-and-resistance-patterns-of-three-generations-of-alk-inhibitors-in-metastatic-inflammatory-myofibroblastic-sarcoma
#6
Barbara M Parker, John V Parker, Anastasios Lymperopoulos, Vijay Konda
Background Little exists currently in research about the mechanisms of resistance of ALK inhibitors in inflammatory myofibroblastic sarcoma. It is known, however, that ALK gene rearrangements are common in inflammatory myofibroblastic tumors, similar to non-small cell lung cancer. In roughly 50% of inflammatory myofibroblastic tumors, gene rearrangement has been found to occur on chromosome 2 at band 2p23. In non-small cell lung cancer, it has been shown that about a third of patients who progress on the first generation ALK inhibitor, crizotinib develops mutations in the ALK kinase domain...
January 1, 2018: Journal of Oncology Pharmacy Practice
https://www.readbyqxmd.com/read/29923797/valproate-augments-niraparib-killing-of-tumor-cells
#7
Laurence Booth, Jane L Roberts, Rumeesa Rais, Andrew Poklepovic, Paul Dent
PARP1 inhibitors are approved therapeutic agents in ovarian carcinomas, and have clinical activity in some breast cancers. As a single agent, niraparib killed ovarian and mammary tumor cells via an ATM-AMPK-ULK1 pathway which resulted in mTOR inactivation and the formation of autophagosomes, temporally followed by autolysosome formation. In parallel, niraparib activated a CD95-FADD-caspase 8 pathway, and collectively these signals caused tumor cell death that was suppressed by knock down of Beclin1, ATG5, CD95, FADD or AIF; or by expression of c-FLIP-s, BCL-XL or dominant negative caspase 9...
June 20, 2018: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/29923480/the-japanese-food-score-and-risk-of-all-cause-cvd-and-cancer-mortality-the-japan-collaborative-cohort-study
#8
Emiko Okada, Koshi Nakamura, Shigekazu Ukawa, Kenji Wakai, Chigusa Date, Hiroyasu Iso, Akiko Tamakoshi
Few studies have reported the association between the Japanese diet as food score and mortality. This study aimed to investigate adherence to the Japanese food score associated with all-cause, CVD and cancer mortality. A total of 58 767 (23 162 men and 34 232 women) Japanese participants aged 40-79 years, who enrolled in the Japan Collaborative Cohort Study between 1988 and 1990, were included. The Japanese food score was derived from the components of seven food groups (beans and bean products, fresh fishes, vegetables, Japanese pickles, fungi, seaweeds and fruits) based on the FFQ...
June 20, 2018: British Journal of Nutrition
https://www.readbyqxmd.com/read/29923330/how-great-is-current-curative-expenditure-and-catastrophic-health-expenditure-among-patients-with-cancer-in-china-a-research-based-on-system-of-health-account-2011
#9
Ang Zheng, Wenjuan Duan, Lin Zhang, Xintong Bao, Xiaoyun Mao, Zhuojun Luo, Feng Jin
In recent years, the incidence and mortality of cancer have witnessed a dramatic increase. Cancer has already caused severe economic burdens on society, especially in developing countries and has become a major public health concern. This study evaluates the medical economic burden, including total current curative expenditure (CCE) and catastrophic health expenditure (CHE) on cancer in Liaoning Province, China. A total of 252 medical institutions were investigated with multistage stratified cluster random sampling...
June 20, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29923274/inseparable-interaction-of-the-prostate-and-inguinal-hernia
#10
REVIEW
Akira Miyajima
With an increase in their prevalence, it has become apparent that both benign prostatic hyperplasia and radical prostatectomy for cancer can induce inguinal hernia development. An inguinal hernia is a common late complication following radical prostatectomy, with an occurrence rate of 12-25%. Following radical prostatectomy, the space of Retzius can develop adhesions to surrounding tissue, often causing difficulty during inguinal hernia repair. Conversely, inguinal hernia repair before radical prostatectomy also induces severe adhesions around the space of Retzius and causes difficulty during radical prostatectomy...
June 19, 2018: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/29920482/tobacco-cessation-in-oncology-care
#11
REVIEW
Emily G Kaiser, Judith J Prochaska, Matthew S Kendra
Globally, tobacco use is a major modifiable risk factor and leading cause of many forms of cancer and cancer death. Tobacco use contributes to poorer prognosis in cancer care. This article reviews the current state of tobacco cessation treatment in oncology. Effective behavioral and pharmacological treatments exist for tobacco cessation, but are not being widely used in oncology treatment settings. Comprehensive tobacco treatment increases success with quitting smoking and can improve oncological and overall health outcomes...
June 19, 2018: Oncology
https://www.readbyqxmd.com/read/29914057/human-papilloma-virus-and-autophagy
#12
REVIEW
Domenico Mattoscio, Alessandro Medda, Susanna Chiocca
Human papilloma viruses (HPVs) are a group of double-stranded DNA viruses known to be the primary cause of cervical cancer. In addition, evidence has now established their role in non-melanoma skin cancers, head and neck cancer (HNC), and the development of other anogenital malignancies. The prevalence of HPV-related HNC, in particular oropharyngeal cancers, is rapidly increasing, foreseeing that HPV-positive oropharyngeal cancers will outnumber uterine cervical cancers in the next 15⁻20 years. Therefore, despite the successful advent of vaccines originally licensed for cervical cancer prevention, HPV burden is still very high, and a better understanding of HPV biology is urgently needed...
June 15, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29913945/prevention-and-treatment-of-trismus-in-head-and-neck-cancer-a-case-report-and-a-systematic-review-of-the-literature
#13
Piotr Wranicz, Bente Brokstad Herlofson, Jan F Evensen, Ulf E Kongsgaard
Introduction Trismus, or limited mouth opening, is a well-known complication of head and neck cancer and its treatment. It may be caused by tumour infiltration into the masticatory muscles or by treatment like surgery and radiotherapy. A limited mouth opening may have a negative effect on nutrition, phonation, dental hygiene and treatment, and quality of life. The severity of this complication depends on the location of the tumour, the type of reconstruction, the total radiation dose, fractionation, and treatment techniques...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29912883/acceptability-of-hpv-vaccines-and-associations-with-perceptions-related-to-hpv-and-hpv-vaccines-among-male-baccalaureate-students-in-hong-kong
#14
Teris Cheung, Joseph T F Lau, Johnson Z Wang, P K H Mo, Y S Ho
OBJECTIVES: The highly infectious human papillomavirus (HPV) causes both genital warts and cervical cancer in women. In 2009, the prevalence of genital warts in Hong Kong was 203.7 per 100,000 person-years. Cervical cancer, more seriously, was the eight most common cancer among women and girls in Hong Kong, accounting for 2.3% of all new cancer cases in females in 2014. Cervical cancer is a significant global public health problem and HPV is a major risk factor leading to the development of cervical cancer...
2018: PloS One
https://www.readbyqxmd.com/read/29912397/streptomyces-shared-microbiome-member-of-soil-and-gut-as-old-friends-against-colon-cancer
#15
Alireza Bolourian, Zahra Mojtahedi
Inflammation contributes to colon cancer initiation. The disease along with allergy and autoimmunity has been on the rise in Western and more recently in developing countries. This shared rise may imply a shared cause. Streptomycetes are known as soil residents and produce numerous antiproliferative, anti-inflammatory/immunosuppressive compounds, e.g. rapamycin and tacrolimus. Recently, Streptomyces has been shown in gut microbiome with a lower prevalence in humans than nonhumans whose microbiomes might be more representative of past humans' in a hunter-gatherer and farming environment...
June 14, 2018: FEMS Microbiology Ecology
https://www.readbyqxmd.com/read/29909222/fallopian-tube-tumorigenesis-and-clinical-implications-for-ovarian-cancer-risk-reduction
#16
REVIEW
Allison A Gockley, Kevin M Elias
Ovarian cancer remains the leading cause of gynecologic cancer death among American women. Prevention is the only proven approach to reduce the incidence of the disease. Oral contraception, tubal ligation, and risk-reducing salpingo-oophorectomy (rrBSO) for high-risk groups are all established risk reduction strategies. This paradigm is changing as recent biologic studies suggest that many ovarian cancers, especially high-grade serous ovarian cancers, originate in the distal end of the fallopian tube rather than the ovarian surface epithelium...
June 11, 2018: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/29907679/the-tumour-suppressor-opcml-promotes-axl-inactivation-by-the-phosphatase-ptprg-in-ovarian-cancer
#17
Jane Antony, Elisa Zanini, Zoe Kelly, Tuan Zea Tan, Evdoxia Karali, Mohammad Alomary, Youngrock Jung, Katherine Nixon, Paula Cunnea, Christina Fotopoulou, Andrew Paterson, Sushmita Roy-Nawathe, Gordon B Mills, Ruby Yun-Ju Huang, Jean Paul Thiery, Hani Gabra, Chiara Recchi
In ovarian cancer, the prometastatic RTK AXL promotes motility, invasion and poor prognosis. Here, we show that reduced survival caused by AXL overexpression can be mitigated by the expression of the GPI-anchored tumour suppressor OPCML Further, we demonstrate that AXL directly interacts with OPCML, preferentially so when AXL is activated by its ligand Gas6. As a consequence, AXL accumulates in cholesterol-rich lipid domains, where OPCML resides. Here, phospho-AXL is brought in proximity to the lipid domain-restricted phosphatase PTPRG, which de-phosphorylates the RTK/ligand complex...
June 15, 2018: EMBO Reports
https://www.readbyqxmd.com/read/29906522/evaluation-of-venous-thromboembolic-complications-in-patients-operated-on-for-pelvic-fracture
#18
Candice Ostrowka, Stéphanie Bonhomme, Pomme Jouffroy, Guillaume Riouallon
INTRODUCTION: Fractures of the pelvis (acetabulum and pelvic ring) are complex in both radiological diagnosis and therapeutic management. They show high risk of thrombosis, with variable rates of venous thromboembolic complications in the literature, ranging from 10% to 50%, with 0.5-10% risk of fatal pulmonary embolism. The objective of the present study was to determine the rate of venous thromboembolic events in a consecutive cohort of pelvic fracture and to attempt to identify thromboembolic risk factors in this population...
June 12, 2018: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/29906025/malignant-tumors-as-cause-of-disability-at-the-instituto-mexicano-del-seguro-social
#19
Edgar Jesús Zitle-García, Alma Lucila Sauceda-Valenzuela, Iván de Jesús Ascencio-Montiel, Jesús García-Paredes
Background: Cancer represents an important issue in health, with the economic impact that it takes. The aim of this paper is to analyze the epidemiological characteristics of a population with social security who was diagnosed with some type of cancer and required a disability pension. Methods: Observational study, retrolective cohort type, carried out at the Instituto Mexicano del Seguro Social (IMSS) with IMSS beneficiaries ruled with a state of disability due to malignancy during the period 2006 to 2012...
March 2018: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/29905007/simultaneous-downregulation-of-mir-21-and-mir-155-through-oleuropein-for-breast-cancer-prevention-and-therapy
#20
Maryam Abtin, Mohammad R Alivand, Mahmoud S Khaniani, Milad Bastami, Mohammad Zaeifizadeh, Sima M Derakhshan
Breast cancer (BC) is the leading cause of cancer mortality in women worldwide. It recently was proven that miRNAs play a critical role in BC development. The use of natural agents for control of cancer by modulating miRNAs is promising. Oleuropein is a natural polyphenolic agent with anti-neoplastic properties and is well tolerated by humans. This study was undertaken to determine the therapeutic effects of oleuropein through modulation of master oncomiRs (miR-21 and miR-155) in BC cells. The present study provides the first link between miRNA and oleuropein as a mechanism in BC...
June 15, 2018: Journal of Cellular Biochemistry
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