keyword
https://read.qxmd.com/read/38302317/organ-specific-aging-in-the-plasma-proteome-predicts-disease
#21
JOURNAL ARTICLE
Michael R Duggan, Keenan A Walker
In their recent Nature paper, Oh et al. use 4979 plasma proteins collected across multiple cohorts, publicly available gene expression data, and machine learning models to identify 11 organ-specific aging scores that are linked to organ-specific disease and mortality risk, including heart failure, cognitive decline, and Alzheimer's disease.
January 31, 2024: Trends in Molecular Medicine
https://read.qxmd.com/read/38286645/effects-of-concomitant-cabg-on-outcomes-in-veterans-who-require-surgery-for-endocarditis
#22
JOURNAL ARTICLE
John Duggan, Alex Peters, Sarah A Halbert, Suzanne Arnott, Jessica LaPiano, Jared Antevil, Gregory D Trachiotis
BACKGROUND: Infective Endocarditis (IE) is a complicated disease frequently accompanied by coronary artery disease (CAD) though no clear guidelines exist for when concomitant revascularization should be undertaken once valve surgery is indicated. Data on this topic within the United States (US) Veteran population, who have unique healthcare needs when compared to the civilian population, is sparse. We investigated the impact of concomitant coronary artery bypass grafting (CABG) on morbidity and mortality in US Veterans requiring surgical management of IE...
January 10, 2024: Heart Surgery Forum
https://read.qxmd.com/read/38257535/were-frailty-identification-criteria-created-equal-a-comparative-case-study-on-continuous-non-invasively-collected-neurocardiovascular-signals-during-an-active-standing-test-in-the-irish-longitudinal-study-on-ageing-tilda
#23
JOURNAL ARTICLE
Feng Xue, Silvin Knight, Emma Connolly, Aisling O'Halloran, Morgana Afonso Shirsath, Louise Newman, Eoin Duggan, Rose Anne Kenny, Roman Romero-Ortuno
BACKGROUND: In this observational study, we compared continuous physiological signals during an active standing test in adults aged 50 years and over, characterised as frail by three different criteria, using data from The Irish Longitudinal Study on Ageing (TILDA). METHODS: This study utilised data from TILDA, an ongoing landmark prospective cohort study of community-dwelling adults aged 50 years or older in Ireland. The initial sampling strategy in TILDA was based on random geodirectory sampling...
January 11, 2024: Sensors
https://read.qxmd.com/read/38244244/ultrasound-guided-nerve-blocks-in-emergency-medicine-practice-2022-updates
#24
JOURNAL ARTICLE
Andrew J Goldsmith, Joseph Brown, Nicole M Duggan, Tomer Finkelberg, Nick Jowkar, Joseph Stegeman, Matthew Riscinti, Arun Nagdev, Richard Amini
OBJECTIVES: In the Emergency Department (ED), ultrasound-guided nerve blocks (UGNBs) have become a cornerstone of multimodal pain regimens. We investigated current national practices of UGNBs across academic medical center EDs, and how these trends have changed over time. METHODS: We conducted a cross-sectional electronic survey of academic EDs with ultrasound fellowships across the United States. Twenty-item questionnaires exploring UGNB practice patterns, training, and complications were distributed between November 2021-June 2022...
January 12, 2024: American Journal of Emergency Medicine
https://read.qxmd.com/read/38240536/stress-ulcer-prophylaxis-versus-placebo-a-blinded-pilot-randomized-controlled-trial-to-evaluate-the-safety-of-two-strategies-in-critically-ill-infants-with-congenital-heart-disease
#25
RANDOMIZED CONTROLLED TRIAL
Kimberly I Mills, Ben D Albert, Lori J Bechard, Stephen Chu, Christopher P Duggan, Aditya Kaza, Seth Rakoff-Nahoum, Lynn A Sleeper, Jane W Newburger, Gregory P Priebe, Nilesh M Mehta
OBJECTIVES: The routine use of stress ulcer prophylaxis (SUP) in infants with congenital heart disease (CHD) in the cardiac ICU (CICU) is controversial. We aimed to conduct a pilot study to explore the feasibility of performing a subsequent larger trial to assess the safety and efficacy of withholding SUP in this population (NCT03667703). DESIGN, SETTING, PATIENTS: Single-center, prospective, double-blinded, parallel group (SUP vs. placebo), pilot randomized controlled pilot trial (RCT) in infants with CHD admitted to the CICU and anticipated to require respiratory support for greater than 24 hours...
February 1, 2024: Pediatric Critical Care Medicine
https://read.qxmd.com/read/38238656/risk-factors-for-moderate-acute-malnutrition-among-children-with-acute-diarrhoea-in-india-and-tanzania-a-secondary-analysis-of-data-from-a-randomized-trial
#26
JOURNAL ARTICLE
Rodrick Kisenge, Usha Dhingra, Chris A Rees, Enju Liu, Arup Dutta, Deb Saikat, Pratibha Dhingra, Sarah Somji, Chris Sudfeld, Jon Simon, Per Ashorn, Sunil Sazawal, Christopher P Duggan, Karim Manji
BACKGROUND: Moderate acute malnutrition (MAM) affects over 30 million children aged < 5 years worldwide. MAM may confer a greater risk of developing severe malnutrition and even mortality in children. Assessing risk factors for MAM may allow for earlier recognition of children at risk of deleterious health outcomes. OBJECTIVE: To determine risk factors associated with the prevalence and development of MAM among children aged 6 to 59 months with acute diarrhoea who received treatment with oral rehydration solution and zinc supplementation...
January 19, 2024: BMC Pediatrics
https://read.qxmd.com/read/38235835/a-retrospective-analysis-of-the-use-of-candesartan-for-migraine-prevention-in-adolescents
#27
JOURNAL ARTICLE
Irene Patniyot, Ankona Banerjee, Kenneth Nobleza, Duc Nguyen, Deanna Duggan, Michelle Holick, Holly Dudley-Harrell
No abstract text is available yet for this article.
January 2024: Headache
https://read.qxmd.com/read/38205760/decreasing-exposure-to-thyroid-radiation-in-an-orthopaedic-theatre-setting-an-educational-intervention
#28
JOURNAL ARTICLE
C Duggan, R Chopra, C Taylor
The use of personal protective equipment (PPE) can significantly reduce staff exposure to harmful radiation and infection. Fluoroscopic procedures in orthopaedic theatre can generate high levels of radiation and good adherence to PPE use is essential to reduce long term cancer risk, including thyroid cancer. To assess baseline compliance with PPE, availability of PPE in theatre and carry out an intervention to promote greater use of PPE. This was a closed-loop interventional study set in a level 1 trauma centre and an elective/rehabilitation unit...
December 2023: Acta Orthopaedica Belgica
https://read.qxmd.com/read/38205059/assessment-of-patient-satisfaction-and-outcomes-after-outpatient-joint-arthroplasty-in-academic-medical-centers
#29
JOURNAL ARTICLE
Soham Ghoshal, Carlos Salazar, Jessica Duggan, Cole Howell, Antonia F Chen, Vivek M Shah
BACKGROUND: There is limited literature evaluating patient satisfaction and outcomes after outpatient joint arthroplasty procedures in academic medical centers (AMCs). The aims of this study are to determine: (1) patients' desires to repeat their procedures and be discharged on the same day, (2) patient-reported outcome measures (PROMs), (3) time to discharge, (4) readmission rates, and (5) factors that predict PROMs in patients undergoing outpatient joint arthroplasty in AMCs. METHODS: A prospective survey was completed by 66 total hip arthroplasty (THA), 35 total knee arthroplasty (TKA), and 180 unicondylar knee arthroplasty (UKA) outpatients who underwent surgery from May 2018 to December 2020 in 2 AMCs...
December 2023: Arthroplasty Today
https://read.qxmd.com/read/38202023/haemodynamic-parameters-underlying-the-relationship-between-sarcopenia-and-blood-pressure-recovery-on-standing
#30
JOURNAL ARTICLE
Eoin Duggan, Silvin P Knight, Feng Xue, Roman Romero-Ortuno
BACKGROUND: Sarcopenia, delayed blood pressure (BP) recovery following standing, and orthostatic hypotension (OH) pose significant clinical challenges associated with ageing. While prior studies have established a link between sarcopenia and impaired BP recovery and OH, the underlying haemodynamic mechanisms remain unclear. METHODS: We enrolled 107 participants aged 50 and above from a falls and syncope clinic, conducting an active stand test with continuous non-invasive haemodynamic measurements...
December 19, 2023: Journal of Clinical Medicine
https://read.qxmd.com/read/38197817/two-randomized-trials-of-low-dose-calcium-supplementation-in-pregnancy
#31
JOURNAL ARTICLE
Pratibha Dwarkanath, Alfa Muhihi, Christopher R Sudfeld, Blair J Wylie, Molin Wang, Nandita Perumal, Tinku Thomas, Shabani M Kinyogoli, Mohamed Bakari, Ryan Fernandez, John-Michael Raj, Ndeniria O Swai, Nirmala Buggi, Rani Shobha, Mary M Sando, Christopher P Duggan, Honorati M Masanja, Anura V Kurpad, Andrea B Pembe, Wafaie W Fawzi
BACKGROUND: The World Health Organization recommends 1500 to 2000 mg of calcium daily as supplementation, divided into three doses, for pregnant persons in populations with low dietary calcium intake in order to reduce the risk of preeclampsia. The complexity of the dosing scheme, however, has led to implementation barriers. METHODS: We conducted two independent randomized trials of calcium supplementation, in India and Tanzania, to assess the noninferiority of a 500-mg daily dose to a 1500-mg daily dose of calcium supplementation...
January 11, 2024: New England Journal of Medicine
https://read.qxmd.com/read/38191937/transanal-minimally-invasive-surgery-tamis-for-local-excision-of-benign-and-malignant-rectal-neoplasia-a-7-year-experience
#32
JOURNAL ARTICLE
William P Duggan, Niall Heagney, Sean Gray, Enda Hannan, John P Burke
PURPOSE: Transanal minimally invasive surgery (TAMIS) is an advanced transanal platform that can be utilised to perform high-quality local excision (LE) of rectal neoplasia. This study describes clinical and midterm oncological outcomes from a single unit's 7-year experience with TAMIS. METHODS: Consecutive patients who underwent TAMIS LE at our institution between January 1st, 2016, and December 31st, 2022, were identified from a prospectively maintained database...
January 9, 2024: Langenbeck's Archives of Surgery
https://read.qxmd.com/read/38190810/surgery-versus-endoscopy-for-the-management-of-painful-chronic-pancreatitis-a-systematic-review-and-meta-analysis-of-randomized-trials
#33
Noel Cassar, Paul Cromwell, Sinead Duggan, Charlotte van Veldhuisen, Marja Boermeester, Marc Besselink, Kevin Conlon
BACKGROUND: Debate exists regarding the optimal treatment for painful chronic pancreatitis (CP). OBJECTIVES: This meta-analysis aims to determine the outcomes of surgical intervention as compared to endoscopy in patients with painful CP. METHODS: A systematic review and meta-analysis including studies from PubMed, Embase, Web of Science and Cochrane databases (1995 onwards) was done by two independent reviewers using PRISMA guidelines. Primary outcome was pain relief...
January 8, 2024: Digestive Surgery
https://read.qxmd.com/read/38185597/effect-of-sequential-burr-passes-on-minimally-invasive-akin-and-first-metatarsal-dorsiflexion-osteotomies
#34
JOURNAL ARTICLE
Matthias Peiffer, Bedri Karaismailoglu, Samir Ghandour, Nour Nassour, Jessica Duggan, Lorena Bejarano-Pineda, Soheil Ashkani-Esfahani, Christopher P Miller
BACKGROUND: Minimally invasive surgical (MIS) osteotomies are increasing as a surgical option for treating midfoot and forefoot conditions. This study aimed to evaluate the impact of each burr pass on the degree of correction, gap size, and alignment in MIS Akin and first metatarsal dorsiflexion osteotomies (DFO). METHODS: MIS Akin and first metatarsal DFO were performed on ten cadaveric specimens. Fluoroscopic measurements included the metatarsal dorsiflexion angle (MDA), dorsal cortical length (MDCL), first phalangeal medial cortical length (PCML) and proximal to distal phalangeal articular angle (PDPAA)...
January 5, 2024: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
https://read.qxmd.com/read/38178353/microbiology-of-infective-endocarditis-in-united-states-veterans-association-between-causative-organism-and-short-and-long-term-outcomes
#35
JOURNAL ARTICLE
John Duggan, Alex Peters, Sarah Halbert, Jared Antevil, Gregory D Trachiotis
BACKGROUND: Previous studies have elucidated the relationship between causative organism and outcomes in infective endocarditis, however this relationship has not been studies in United States Veterans. The aim of this manuscript is to evaluate the association between causative organism and short-term and long-term outcomes in United States (US) Veterans with infective endocarditis (IE) requiring surgical management between 2010-2020. METHODS: We analyzed 489 patients with surgically treated IE from the Veterans Affairs (VA) Surgical Quality Improvement Program and the VA Informatics and Computing Infrastructure databases...
December 26, 2023: Heart Surgery Forum
https://read.qxmd.com/read/38154887/co-designing-a-nature-based-intervention-to-promote-postnatal-mental-health-for-mothers-and-their-infants-a-complex-intervention-development-study-in-england
#36
JOURNAL ARTICLE
Katherine Hall, Jonathan Evans, Rosa Roberts, Richard Brown, Lucy Duggan, Melanie Williamson, Paul Moran, Katrina M Turner, Christopher Barnes
OBJECTIVES: There is burgeoning evidence for the potential of nature-based interventions to improve wellbeing. However, the role of nature in enhancing maternal mental health, child development and early relationships remains relatively unexplored. This study aimed to develop a co-designed nature-based intervention to improve postnatal mothers' and infants' wellbeing. DESIGN, SETTING AND PARTICIPANTS: Person-based and co-design approaches informed the planning and design of the postnatal nature-based intervention...
December 28, 2023: BMJ Open
https://read.qxmd.com/read/38153693/improving-anthropometric-measurements-in-hospitalized-children-a-quality-improvement-project
#37
JOURNAL ARTICLE
Sabrina Persaud, Bridget M Hron, Coral Rudie, Patricia Mantell, Prerna S Kahlon, Katelyn Ariagno, Al Ozonoff, Shrunjal Trivedi, Carlos Yugar, Nilesh M Mehta, Michelle Raymond, Christopher P Duggan, Susanna Y Huh
BACKGROUND: The objective of this quality-improvement project was to increase documentation rates of anthropometrics (measured weight, length/height, and body mass index [BMI], which are critical to identify patients at malnutrition (undernutrition) risk) from <50% to 80% within 24 hours of hospital admission for pediatric patients. METHODS: Multidisciplinary champion teams on surgical, cardiac, and intensive care (ICU) pilot units were established to identify and iteratively test interventions addressing barriers to documentation from May 2016 to June 2018...
December 28, 2023: Nutrition in Clinical Practice
https://read.qxmd.com/read/38140676/breaking-the-silence-regulation-of-hiv-transcription-and-latency-on-the-road-to-a-cure
#38
REVIEW
Natasha N Duggan, Tatjana Dragic, Sumit K Chanda, Lars Pache
Antiretroviral therapy (ART) has brought the HIV/AIDS epidemic under control, but a curative strategy for viral eradication is still needed. The cessation of ART results in rapid viral rebound from latently infected CD4+ T cells, showing that control of viral replication alone does not fully restore immune function, nor does it eradicate viral reservoirs. With a better understanding of factors and mechanisms that promote viral latency, current approaches are primarily focused on the permanent silencing of latently infected cells ("block and lock") or reactivating HIV-1 gene expression in latently infected cells, in combination with immune restoration strategies to eliminate HIV infected cells from the host ("shock and kill")...
December 15, 2023: Viruses
https://read.qxmd.com/read/38131137/transcriptional-profiling-of-zebrafish-identifies-host-factors-controlling-susceptibility-to-shigella-flexneri
#39
JOURNAL ARTICLE
Vincenzo Torraca, Richard J White, Ian M Sealy, Maria Mazon-Moya, Gina Duggan, Alexandra Willis, Elisabeth M Busch-Nentwich, Serge Mostowy
Shigella flexneri is a human-adapted pathovar of Escherichia coli that can invade the intestinal epithelium, causing inflammation and bacillary dysentery. Although an important human pathogen, the host response to S. flexneri has not been fully described. Zebrafish larvae represent a valuable model to study human infections in vivo. Here we use a Shigella-zebrafish infection model to generate mRNA expression profiles of host response to Shigella infection at the whole animal level. Immune response-related processes dominate the signature of early Shigella infection (6 hours post-infection)...
December 22, 2023: Disease Models & Mechanisms
https://read.qxmd.com/read/38106940/trends-in-orthopedic-management-of-distal-radius-fractures-among-medicare-beneficiaries-from-2019-to-2020-a-claims-analysis
#40
JOURNAL ARTICLE
Luke D He, Jessica L Duggan, Jonathan Lans, Carl M Harper, Tamara D Rozental
PURPOSE: Radius and ulna fractures are among the most common fractures. These fractures are managed through operative or nonsurgical treatment, with varying implications in terms of cost and functional outcome. There are few studies that robustly characterize the management of distal radius fractures (DRFs) in the United States during the COVID-19 pandemic. Furthermore, this has not been studied among the Medicare patient population, who are particularly vulnerable to fragility fractures and COVID-19...
November 2023: Journal of hand surgery global online
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