Pratibha Dwarkanath, Alfa Muhihi, Christopher R Sudfeld, Blair J Wylie, Molin Wang, Nandita Perumal, Tinku Thomas, Shabani M Kinyogoli, Mohamed Bakari, Ryan Fernandez, John-Michael Raj, Ndeniria O Swai, Nirmala Buggi, Rani Shobha, Mary M Sando, Christopher P Duggan, Honorati M Masanja, Anura V Kurpad, Andrea B Pembe, Wafaie W Fawzi
BACKGROUND: The World Health Organization recommends 1500 to 2000 mg of calcium daily as supplementation, divided into three doses, for pregnant persons in populations with low dietary calcium intake in order to reduce the risk of preeclampsia. The complexity of the dosing scheme, however, has led to implementation barriers. METHODS: We conducted two independent randomized trials of calcium supplementation, in India and Tanzania, to assess the noninferiority of a 500-mg daily dose to a 1500-mg daily dose of calcium supplementation...
January 11, 2024: New England Journal of Medicine