Read by QxMD icon Read


James Rourke, Danielle O'Keefe, Mohamed Ravalia, Scott Moffatt, Wanda Parsons, Norah Duggan, Katherine Stringer, Michael Jong, Kristin Harris Walsh, Janelle Hippe
OBJECTIVE: To assess Memorial University of Newfoundland's (MUN's) commitment to a comprehensive pathways approach to rural family practice, and to determine the national and provincial effects of applying this approach. DESIGN: Analysis of anonymized secondary data. SETTING: Canada. PARTICIPANTS: Memorial's medical degree (MD) graduates practising family medicine in Newfoundland and Labrador as of January 2015 (N = 305), MUN's 2011 and 2012 MD graduates (N = 120), and physicians who completed family medicine training programs in Canada between 2004 and 2013 and who were practising in Canada 2 years after completion of their postgraduate training (N = 8091)...
March 2018: Canadian Family Physician Médecin de Famille Canadien
Patrick T Reeves, Matthew A Borgman, Nicole W Caldwell, Leela Patel, James Aden, John P Duggan, Maria L Serio-Melvin, Elizabeth A Mann-Salinas
OBJECTIVE: The Advanced Burn Life Support (ABLS) program is a burn-education curriculum nearly 30 years in the making, focusing on the unique challenges of the first 24h of care after burn injury. Our team applied high fidelity human patient simulation (HFHPS) to the established ABLS curriculum. Our hypothesis was that HFHPS would be a feasible, easily replicable, and valuable adjunct to the current curriculum that would enhance learner experience. METHODS: This prospective, evidenced-based practice project was conducted in a single simulation center employing the American Burn Association's ABLS curriculum using HFHPS...
March 10, 2018: Burns: Journal of the International Society for Burn Injuries
L V Duggan, S L Lockhart, T M Cook, E P O'Sullivan, T Dare, P A Baker
In this exploratory study we describe the utility of smartphone technology for anonymous retrospective observational data collection of emergency front-of-neck airway management. The medical community continues to debate the optimal technique for emergency front-of-neck airway management. Although individual clinicians infrequently perform this procedure, hundreds are performed annually worldwide. Ubiquitous smartphone technology and internet connectivity have created the opportunity to collect these data. We created the 'Airway App', a smartphone application to capture the experiences of healthcare providers involved in emergency front-of-neck airway procedures...
March 13, 2018: Anaesthesia
Sana Syed, Najeeha T Iqbal, Kamran Sadiq, Jennie Z Ma, Tauseef Akhund, Wenjun Xin, Sean R Moore, Enju Liu, Shahida Qureshi, Kerri Gosselin, Andrew Gewirtz, Christopher P Duggan, S Asad Ali
BACKGROUND: Environmental Enteric Dysfunction (EED) in children from low-income countries has been linked to linear growth declines. There is a critical need to identify sensitive and early EED biomarkers. OBJECTIVE: Determine whether levels of antibodies against bacterial components flagellin (flic) and lipopolysaccharide (LPS) predict poor growth. DESIGN/METHODS: In a prospective birth cohort of 380 children in rural Pakistan blood and stool samples were obtained at ages 6 and 9 months...
2018: PloS One
Hazel M Ní Chonchubhair, Yasir Bashir, Mark Dobson, Barbara M Ryan, Sinead N Duggan, Kevin C Conlon
BACKGROUND: Small intestinal bacterial overgrowth (SIBO) is a condition characterised by symptoms similar to pancreatic exocrine insufficiency (PEI) in chronic pancreatitis patients. SIBO is thought to complicate chronic pancreatitis in up to 92% of cases; however, studies are heterogeneous and protocols non-standardised. SIBO may be determined by measuring lung air-expiration of either hydrogen or methane which are by-products of small bowel bacterial fermentation of intraluminal substrates such as carbohydrates...
February 24, 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
Hyun Hanna Kim, Tricia Washburn, Kathy Marceau, Sue Duggan-Ball, Patricia Raymond
[Full article available at].
March 1, 2018: Rhode Island Medical Journal
Aylin Sar, Qiuli Duan, Moosa Khalil, Lisa M DiFrancesco, Carol Ewanowich, Alice Lytwyn, Bojana Djordjevic, Doha Itani, Sandra Lee, Martin Köbel, Sarah Glaze, Elena Park, Máire A Duggan
OBJECTIVE: The aim of the study was to compare the reproducibility of malignant glandular tumors of the uterine cervix classified per World Health Organization (WHO) 2003 and 2014. MATERIALS AND METHODS: Two pathologists reviewed 228 cases composed of adenocarcinoma in situ and 22 adenocarcinoma histotypes and selected 405 representative hematoxylin and eosin slides, which were digitally scanned. Six other pathologists (3 gynecological and 3 anatomical) independently reviewed and classified the images per both WHO classifications...
February 23, 2018: Journal of Lower Genital Tract Disease
Brita Askeland Winje, Ingrid Kvestad, Srinivasan Krishnamachari, Karim Manji, Sunita Taneja, David C Bellinger, Nita Bhandari, Shruti Bisht, Anne Marie Darling, Christopher P Duggan, Wafaie Fawzi, Mari Hysing, Tivendra Kumar, Anura V Kurpad, Christopher R Sudfeld, Erling Svensen, Susan Thomas, Tor A Strand
INTRODUCTION: As many as 250 million children under the age of 5 may not be reaching their full developmental potential partly due to poor nutrition during pregnancy and the first 2 years of life. Micronutrients, including vitamin B12 , are important for the development of brain structure and function; however, the timing, duration and severity of deficiencies may alter the impact on functional development outcomes. Consequently, to fully explore the effect of vitamin B12 on cognitive function, it is crucial to measure neurodevelopment at different ages, in different populations and with vitamin B12 supplementation at different times during the critical periods of neurodevelopment...
February 22, 2018: BMJ Open
Achsah F Dorsey, Amanda L Thompson, Ronald E Kleinman, Christopher P Duggan, Mary E Penny
OBJECTIVES: This article explores the optimal iron hypothesis through secondary data analysis of the association between hemoglobin levels and morbidity among children living in Canto Grande, a peri-urban community located on the outskirts of Lima, Peru. METHODS: Risk ratios were used to test whether lower iron status, assessed using the HemoCue B-Hemoglobin System, was associated with an increased relative risk of morbidity symptoms compared to iron replete status, controlling for infant age, sex, weight for height z-score, maternal education, and repeated measures in 515 infants aged 6-12 months...
February 19, 2018: American Journal of Human Biology: the Official Journal of the Human Biology Council
Giovanni Benelli, Mary Frances Duggan
Emerging infectious diseases (EIDs) are spread by direct and/or indirect contacts between a pathogen or parasite and their hosts. Arthropod vectors have evolved as excellent bloodsuckers, providing an elegant transportation mode for a wide number of infectious agents. The nature of pathogen and parasite transfer and the models used to predict how a disease might spread are magnified in complexity when an arthropod vector is part of the disease cycle. One Health is a worldwide strategy for expanding interdisciplinary collaborations and communications in all aspects of health care for humans, animals and the environment...
February 15, 2018: Acta Tropica
Zoe Patterson Ross, Jennifer Klunk, Gino Fornaciari, Valentina Giuffra, Sebastian Duchêne, Ana T Duggan, Debi Poinar, Mark W Douglas, John-Sebastian Eden, Edward C Holmes, Hendrik N Poinar
[This corrects the article DOI: 10.1371/journal.ppat.1006750.].
February 2018: PLoS Pathogens
Alessandro Tamburrini, Aurelio Majorino, Simon Duggan, Sanjay Jogai, Aiman Alzetani
Development of distant metastases from renal cell carcinoma (RCC) is a frequent occurrence and, in nearly 95% of the cases, secondary lesions present within 5 years following nephrectomy. We performed a left pneumonectomy for a peri-hilar lung mass in an 81-year-old man with history of kidney cancer, resected 37 years earlier. Histopathological examination revealed a solitary lung metastasis from RCC, relapsed after an extraordinary 37-year time interval. To the best of our knowledge, this remarkable case represents the longest time interval between radical nephrectomy for RCC and the occurrence of a pulmonary metastasis...
October 2017: Journal of Surgical Case Reports
Hannah A Blair, Sean T Duggan
Belimumab (Benlysta®) is a human immunoglobulin G1λ monoclonal antibody that inhibits the binding of soluble B lymphocyte stimulator to B cells. It is the only biological agent currently approved for the treatment of non-renal systemic lupus erythematosus (SLE). Belimumab is approved in the EU, the USA and other countries as add-on therapy in adult patients with active, autoantibody-positive SLE despite standard therapy. In phase III trials, treatment with IV or SC belimumab plus standard therapy was effective in terms of reducing overall disease activity and reducing the incidence and severity of flares, without worsening of patients' overall condition or the development of significant disease activity in new organ systems...
February 2, 2018: Drugs
Goli Samimi, Britton Trabert, Máire A Duggan, Jennifer L Robinson, Kisha I Coa, Elizabeth Waibel, Edna Garcia, Lori M Minasian, Mark E Sherman
OBJECTIVE: Many high-grade serous carcinomas initiate in fallopian tubes as serous tubal intraepithelial carcinoma (STIC), a microscopic lesion identified with specimen processing according to the Sectioning and Extensive Examination of the Fimbria protocol (SEE-Fim). Given that the tubal origin of these cancers was recently recognized, we conducted a survey of pathology practices to assess processing protocols that are applied to gynecologic surgical pathology specimens in clinical contexts in which finding STIC might have different implications...
January 25, 2018: Gynecologic Oncology
Ryan C Brindle, Katherine A Duggan, Matthew R Cribbet, Christopher E Kline, Robert T Krafty, Julian F Thayer, Suresh R Mulukutla, Martica H Hall
OBJECTIVE: Exaggerated cardiovascular reactivity to acute psychological stress has been associated with increased carotid intima-media thickness (IMT). However, inter-study variability in this relationship suggests the presence of moderating factors. The current study aimed to test the hypothesis that poor nocturnal sleep, defined as short total sleep time or low slow-wave sleep (SWS), would moderate the relationship between cardiovascular reactivity and IMT. METHODS: Participants (N=99, 65...
January 29, 2018: Psychosomatic Medicine
Wioleta Kowalczyk, Julie Sanchez, Phillipe Kraaz, Oliver E Hutt, David N Haylock, Peter J Duggan
A 54-member library of boronated octapeptides, with all but the boronated residue being proteinogenic, was tested for affinity to a set of saccharides commonly found on the terminus of mammalian glycans. After experimentation with a high-throughput dye-displacement assay, attention was focused on isothermal titration calorimetry as a tool to provide reliable affinity data, including enthalpy and entropy of binding. A small number of boronated peptides showed higher affinity and significant selectivity for N-acetylneuraminic acid over methyl-α-d-galactopyranoside, methyl-α/β-l-fucopyranoside and N-acetyl-d-glucosamine...
January 30, 2018: Biopolymers
Tess R Scavuzzo-Duggan, Arielle M Chaves, Abhishek Singh, Latsavongsakda Sethaphong, Erin Slabaugh, Yaroslava G Yingling, Candace H Haigler, Alison W Roberts
Cellulose synthases (CESAs) are glycosyltransferases that catalyze formation of cellulose microfibrils in plant cell walls. Seed plant CESA isoforms cluster in six phylogenetic clades, whose non-interchangeable members play distinct roles within Cellulose Synthesis Complexes (CSCs). A 'class specific region' (CSR) with higher sequence similarity within vs. between functional CESA classes has been suggested to contribute to specific activities or interactions of different isoforms. We investigated CESA isoform specificity in the moss Physcomitrella patens (Hedw...
January 30, 2018: Journal of Integrative Plant Biology
Ruth Melia, Kady Francis, Jim Duggan, John Bogue, Mary O'Sullivan, Derek Chambers, Karen Young
BACKGROUND: Previous research has reported that two of the major barriers to help-seeking for individuals at risk of suicide are stigma and geographical isolation. Mobile technology offers a potential means of delivering evidence-based interventions with greater specificity to the individual, and at the time that it is needed. Despite documented motivation by at-risk individuals to use mobile technology to track mental health and to support psychological interventions, there is a shortfall of outcomes data on the efficacy of mobile health (mHealth) technology on suicide-specific outcomes...
January 26, 2018: JMIR Research Protocols
Danielle Ní Chróinín, Chantelle Ní Chróinín, Layan Akijian, Elizabeth L Callaly, Niamh Hannon, Lisa Kelly, Michael Marnane, Áine Merwick, Órla Sheehan, Gillian Horgan, Joseph Duggan, Lorraine Kyne, Eamon Dolan, Seán Murphy, David Williams, Peter J Kelly
BACKGROUND: Few population-based studies have assessed lipid adherence to international guidelines for primary and secondary prevention in stroke/transient ischaemic attack (TIA) patients. AIMS: This study aims to evaluate adherence to lipid-lowering therapy (LLT) guidelines amongst patients with ischaemic stroke/TIA. METHODS: Using hot and cold pursuit methods from multiple hospital/community sources, all stroke and TIA cases in North Dublin City were prospectively ascertained over a 1-year period...
January 24, 2018: Irish Journal of Medical Science
Andrew Stiff, Prashant Trikha, Bethany L Mundy-Bosse, Elizabeth L McMichael, Thomas A Mace, Brooke Benner, Kari Kendra, Amanda Campbell, Shalini Gautam, David Abood, Ian Landi, Vincent Hsu, Megan C Duggan, Robert Wesolowski, Matthew Old, John H Howard, Lianbo Yu, Nancy Stasik, Thomas Olencki, Natarajan Muthusamy, Susheela Tridandapani, John C Byrd, Michael A Caligiuri, William E Carson
PURPOSE: Monoclonal antibodies (mAb) are used to treat solid and hematological malignancies, and work in part through Fc receptors (FcR) on natural killer cells (NK). However, FcR mediated functions of NK cells from cancer patients are significantly impaired. Identifying the mechanisms of this dysfunction and impaired response to mAb therapy could lead to combination therapies and enhance mAb therapy.  Experimental Design: Co-cultures of autologous NK cells and MDSC from cancer patients were used to study the effect of MDSC on NK cell FcR mediated functions including antibody dependent cellular cytotoxicity, cytokine production, and signal transduction in vitro...
January 23, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"