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https://www.readbyqxmd.com/read/29667548/flavonoids-and-platelet-derived-thrombotic-disorders
#1
Jose J Lopez, Mohammed El Haouari, Isaac Jardin, Nieves Alonso, Sergio Regodon, Raquel Diez Bello, Pedro Cosme Redondo, Juan A Rosado
Thrombotic disorders are characterized by an increase in the probability of the formation of unnecessary thrombi that might be due to the activation of the coagulation cascade or the circulating platelets. Platelets or thrombocytes play an essential role in hemostasis but abnormal platelet function leads to the development of a number of cardiovascular complications, including thrombotic disorders. Under pathological conditions, platelets are associated with the development of different thrombotic disorders, including atherosclerosis, arterial thrombosis and stroke, deep venous thrombosis and pulmonary embolism; therefore, platelets are the target of a number of anti-thrombotic strategies...
April 17, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29665795/design-and-methods-of-the-removal-hd-study-a-trial-evaluating-mid-cut-off-value-membrane-clearance-of-albumin-and-light-chains-in-haemodialysis-patients
#2
R Krishnasamy, C M Hawley, M J Jardine, M A Roberts, Y J Cho, M G Wong, A Heath, C L Nelson, S Sen, P F Mount, E M Pascoe, D Darssan, L A Vergara, P A Paul-Brent, N D Toussaint, D W Johnson, C A Hutchison
BACKGROUND: Removal of uraemic toxins is inadequate using current dialysis strategies. A new class of dialysis membranes have been developed that allow clearance of larger middle molecules. The REMOVAL-HD study (a tRial Evaluating Mid cut-Off Value membrane clearance of Albumin and Light chains in HaemoDialysis patients) will address safety, efficacy and the impact on patient-centred outcomes with the use of a mid cut-off (MCO) dialyser in a chronic haemodialysis (HD) population. METHODS: REMOVAL-HD is an open label, prospective, non-randomised, single-arm, multi-centre device study in 85 chronic HD participants...
April 17, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29594509/exertional-heat-illness-incidence-and-on-site-medical-team-preparedness-in-warm-weather
#3
Yuri Hosokawa, William M Adams, Luke N Belval, Robert J Davis, Robert A Huggins, John F Jardine, Rachel K Katch, Rebecca L Stearns, Douglas J Casa
To investigate the influence of estimated wet bulb globe temperature (WBGT) and the International Institute of Race Medicine (IIRM) activity modification guidelines on the incidence of exertional heat stroke (EHS) and heat exhaustion (HEx) and the ability of an on-site medical team to treat those afflicted. Medical records of EHS and HEx patients over a 17-year period from the New Balance Falmouth Road Race were examined. Climatologic data from nearby weather stations were obtained to calculate WBGT with the Australian Bureau of Meteorology (WBGTA ) and Liljegren (WBGTL ) models...
March 29, 2018: International Journal of Biometeorology
https://www.readbyqxmd.com/read/29580068/gut-interpretations-how-difficulties-in-emotion-regulation-may-help-explain-the-relation-of-visceral-sensitivity-with-depression-and-anxiety-among-young-adults-with-gastrointestinal-symptoms
#4
Michael Zvolensky, Charles Jardin, Samantha G Farris, Brooke Kauffman, Jafar Bakhshaie, Lorra Garey, Kara Manning, Andrew H Rogers, Nubia A Mayorga
It is widely recognized that abdominal pain and discomfort are common problems in the United States and are often associated with negative quality of life. The prevalence of anxiety/depression elevations and disorders among persons with gastrointestinal disturbances (GI) is estimated to be at least two to three times the rate in the general population. Visceral sensitivity reflects anxiety about GI sensations and its accompanying contexts and often leads to worsening of sensations (e.g. bloating, upset stomach, diarrhea)...
March 26, 2018: Psychology, Health & Medicine
https://www.readbyqxmd.com/read/29553356/anxiety-sensitivity-in-association-with-alcohol-related-behaviors-among-college-students-the-role-of-negative-urgency
#5
Brooke Y Kauffman, Lorra Garey, Daniel J Paulus, Charles Jardin, Andres G Viana, Clayton Neighbors, Michael J Zvolensky
OBJECTIVE: Extant work has documented the relationship between anxiety sensitivity (AS) and problematic alcohol-related behaviors. However, research on the underlying mechanisms may serve to better explain their association. METHOD: The present study tested the hypothesis that AS would exert an indirect effect on alcohol-related behaviors through negative urgency among a sample of 507 college students (74.4% female; mean age = 22.07 years; SD = 3.83; age range: 18-47 years) who reported at least one heavy episodic drinking (HED) event in the previous month and at least one lifetime sexual partner...
March 2018: Journal of Studies on Alcohol and Drugs
https://www.readbyqxmd.com/read/29543479/acculturative-stress-emotion-regulation-and-affective-symptomology-among-latino-a-college-students
#6
Nubia A Mayorga, Charles Jardin, Jafar Bakhshaie, Lorra Garey, Andres G Viana, Jodi Berger Cardoso, Michael Zvolensky
Although recent work has highlighted the relation of acculturative stress with depression and anxiety symptoms specifically among Latino/a university students, the potential mechanisms underlying these associations remain relatively unknown. The present study aims to examine difficulties in emotion regulation as an explanatory factor in the relation of acculturative stress with symptoms of depression, suicidality, social anxiety, and anxious arousal. A sample of 448 Latino/a college students (Mage = 20.67 years, SD = 1...
March 2018: Journal of Counseling Psychology
https://www.readbyqxmd.com/read/29527701/identification-of-an-il-1-induced-gene-expression-pattern-in-ar-pca-cells-that-mimics-the-molecular-phenotype-of-ar-pca-cells
#7
Shayna E Thomas-Jardin, Mohammed S Kanchwala, Joan Jacob, Sana Merchant, Rachel K Meade, Nagham M Gahnim, Afshan F Nawas, Chao Xing, Nikki A Delk
BACKGROUND: In immunosurveillance, bone-derived immune cells infiltrate the tumor and secrete inflammatory cytokines to destroy cancer cells. However, cancer cells have evolved mechanisms to usurp inflammatory cytokines to promote tumor progression. In particular, the inflammatory cytokine, interleukin-1 (IL-1), is elevated in prostate cancer (PCa) patient tissue and serum, and promotes PCa bone metastasis. IL-1 also represses androgen receptor (AR) accumulation and activity in PCa cells, yet the cells remain viable and tumorigenic; suggesting that IL-1 may also contribute to AR-targeted therapy resistance...
March 11, 2018: Prostate
https://www.readbyqxmd.com/read/29523554/lysosomal-cholesterol-hydrolysis-couples-efferocytosis-to-anti-inflammatory-oxysterol-production
#8
Manon Viaud, Stoyan Ivanov, Nemanja Vujic, Madalina Duta-Mare, Lazaro-Emilio Aira, Thibault Barouillet, Elsa Garcia, François Orange, Isabelle Dugail, Isabelle Hainault, Christian Stehlik, Sandrine Marchetti, Laurent Boyer, Rodolphe Guinamard, Fabienne Foufelle, Andrea E Bochem, Kees G Hovingh, Edward B Thorp, Emmanuel L Gautier, Dagmar Kratky, Paul A Da Silva-Jardine, Laurent Yvan-Charvet
<u>Rationale:</u> Macrophages face a substantial amount of cholesterol following the ingestion of apoptotic cells and the lysosomal acid lipase (LIPA) has a major role in hydrolyzing cholesteryl esters in the endocytic compartment. <u>Objective:</u> Here, we directly investigated the role of LIPA-mediated clearance of apoptotic cells both in vitro and in vivo. <u>Methods and Results:</u> We show that LIPA inhibition causes a defective efferocytic response due to impaired generation of 25-OHC and 27-OHC...
March 9, 2018: Circulation Research
https://www.readbyqxmd.com/read/29517402/frequency-of-virus-coinfection-in-raccoons-procyon-lotor-and-striped-skunks-mephitis-mephitis-during-a-concurrent-rabies-and-canine-distemper-outbreak
#9
Claire M Jardine, Tore Buchanan, Davor Ojkic, G Douglas Campbell, Jeff Bowman
Rabies and canine distemper virus infections in wildlife share similar presenting signs. Canine distemper virus was detected using real-time PCR of conjunctival swabs in rabies positive raccoons (22/32) and skunks (7/34) during a concurrent rabies and canine distemper outbreak in Ontario, Canada in 2015-2016. Coinfections with both viruses should be considered, particularly in distemper endemic areas that are at risk of rabies incursion.
March 8, 2018: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/29515032/peripheral-tissues-reprogram-cd8-t-cells-for-pathogenicity-during-graft-versus-host-disease
#10
Pedro Santos E Sousa, Séverine Ciré, Thomas Conlan, Laura Jardine, Claire Tkacz, Ivana R Ferrer, Cara Lomas, Sophie Ward, Heather West, Simone Dertschnig, Sven Blobner, Terry K Means, Stephen Henderson, Daniel H Kaplan, Matthew Collin, Vincent Plagnol, Clare L Bennett, Ronjon Chakraverty
Graft-versus-host disease (GVHD) is a life-threatening complication of allogeneic stem cell transplantation induced by the influx of donor-derived effector T cells (TE) into peripheral tissues. Current treatment strategies rely on targeting systemic T cells; however, the precise location and nature of instructions that program TE to become pathogenic and trigger injury are unknown. We therefore used weighted gene coexpression network analysis to construct an unbiased spatial map of TE differentiation during the evolution of GVHD and identified wide variation in effector programs in mice and humans according to location...
March 8, 2018: JCI Insight
https://www.readbyqxmd.com/read/29507008/exploring-the-clinical-relevance-of-providing-increased-removal-of-large-middle-molecules
#11
REVIEW
Martin Wolley, Meg Jardine, Colin A Hutchison
Dialysis technologies have continued to advance over recent decades; however, these advancements have not always been met with improved patient outcomes. In part, the high morbidity and mortality associated with dialysis have been attributed to a group of uremic toxins, which are described as "difficult to remove." With a new generation of hemodialysis membranes now making meaningful clearance of these molecules possible, it is an apt time to review the clinical relevance of these middle molecules...
March 5, 2018: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29501729/stat6-is-a-cargo-of-exportin-1-biological-relevance-in-primary-mediastinal-b-cell-lymphoma
#12
Hadjer Miloudi, Karen Leroy, Fabrice Jardin, Brigitte Sola
Primary mediastinal B-cell lymphoma (PMBL) is a distinct B-cell lymphoma subtype with unique clinicopathological and molecular features. PMBL cells are characterised by several genetic abnormalities that conduct to the constitutive activation of the Janus kinase 2/signal transducer and activator of transcription 6 (JAK2/STAT6) signalling pathway. Among recurrent genetic changes in PMBL, we previously reported that the XPO1 gene encoding exportin 1 that controls the nuclear export of cargo proteins and RNAs, is mutated (p...
March 1, 2018: Cellular Signalling
https://www.readbyqxmd.com/read/29500990/a-synthetic-stroma-free-germinal-center-niche-for-efficient-generation-of-humoral-immunity-ex-vivo
#13
Kyung-Ho Roh, Hannah W Song, Pallab Pradhan, Kevin Bai, Caitlin D Bohannon, Gordon Dale, Jardin Leleux, Joshy Jacob, Krishnendu Roy
B cells play a major role in the adaptive immune response by producing antigen-specific antibodies against pathogens and imparting immunological memory. Following infection or vaccination, antibody-secreting B cells and memory B cells are generated in specialized regions of lymph nodes and spleens, called germinal centers. Here, we report a fully synthetic ex-vivo system that recapitulates the generation of antigen-specific germinal-center (GC) like B cells using material-surface driven polyvalent signaling...
February 21, 2018: Biomaterials
https://www.readbyqxmd.com/read/29495876/polarisation-in-spin-echo-experiments-multi-point-and-lock-in-measurements
#14
Anton Tamtögl, Benjamin Davey, David J Ward, Andrew P Jardine, John Ellis, William Allison
Spin-echo instruments are typically used to measure diffusive processes and the dynamics and motion in samples on ps and ns time scales. A key aspect of the spin-echo technique is to determine the polarisation of a particle beam. We present two methods for measuring the spin polarisation in spin-echo experiments. The current method in use is based on taking a number of discrete readings. The implementation of a new method involves continuously rotating the spin and measuring its polarisation after being scattered from the sample...
February 2018: Review of Scientific Instruments
https://www.readbyqxmd.com/read/29486007/a-field-based-indicator-for-determining-the-likelihood-of-ixodes-scapularis-establishment-at-sites-in-ontario-canada
#15
Katie M Clow, Nicholas H Ogden, L Robbin Lindsay, Curtis B Russell, Pascal Michel, David L Pearl, Claire M Jardine
The emergence of the vector Ixodes scapularis in Ontario, Canada poses a significant public health risk. Both passive and active surveillance approaches have been employed by public health professionals (i.e., government employees) to monitor for the range expansion of this tick. Field surveillance using drag sampling for questing ticks is a recognized and effective method to identify reproducing tick populations. The degree of effort (i.e., number of visits per site) can enhance the sensitivity and specificity of surveillance, but increased effort conflicts with the cost to public health for field surveillance...
2018: PloS One
https://www.readbyqxmd.com/read/29481237/results-from-the-super-cryogenic-dark-matter-search-experiment-at-soudan
#16
R Agnese, T Aramaki, I J Arnquist, W Baker, D Balakishiyeva, S Banik, D Barker, R Basu Thakur, D A Bauer, T Binder, M A Bowles, P L Brink, R Bunker, B Cabrera, D O Caldwell, R Calkins, C Cartaro, D G Cerdeño, Y Chang, Y Chen, J Cooley, B Cornell, P Cushman, M Daal, P C F Di Stefano, T Doughty, E Fascione, E Figueroa-Feliciano, M Fritts, G Gerbier, R Germond, M Ghaith, G L Godfrey, S R Golwala, J Hall, H R Harris, Z Hong, E W Hoppe, L Hsu, M E Huber, V Iyer, D Jardin, A Jastram, C Jena, M H Kelsey, A Kennedy, A Kubik, N A Kurinsky, B Loer, E Lopez Asamar, P Lukens, D MacDonell, R Mahapatra, V Mandic, N Mast, E H Miller, N Mirabolfathi, B Mohanty, J D Morales Mendoza, J Nelson, J L Orrell, S M Oser, K Page, W A Page, R Partridge, M Penalver Martinez, M Pepin, A Phipps, S Poudel, M Pyle, H Qiu, W Rau, P Redl, A Reisetter, T Reynolds, A Roberts, A E Robinson, H E Rogers, T Saab, B Sadoulet, J Sander, K Schneck, R W Schnee, S Scorza, K Senapati, B Serfass, D Speller, M Stein, J Street, H A Tanaka, D Toback, R Underwood, A N Villano, B von Krosigk, B Welliver, J S Wilson, M J Wilson, D H Wright, S Yellin, J J Yen, B A Young, X Zhang, X Zhao
We report the result of a blinded search for weakly interacting massive particles (WIMPs) using the majority of the SuperCDMS Soudan data set. With an exposure of 1690 kg d, a single candidate event is observed, consistent with expected backgrounds. This analysis (combined with previous Ge results) sets an upper limit on the spin-independent WIMP-nucleon cross section of 1.4×10^{-44} (1.0×10^{-44})  cm^{2} at 46  GeV/c^{2}. These results set the strongest limits for WIMP-germanium-nucleus interactions for masses >12  GeV/c^{2}...
February 9, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/29475724/a-gene-expression-profiling-score-for-prediction-of-outcome-in-patients-with-follicular-lymphoma-a-retrospective-training-and-validation-analysis-in-three-international-cohorts
#17
Sarah Huet, Bruno Tesson, Jean-Philippe Jais, Andrew L Feldman, Laura Magnano, Emilie Thomas, Alexandra Traverse-Glehen, Benoit Albaud, Marjorie Carrère, Luc Xerri, Stephen M Ansell, Lucile Baseggio, Cécile Reyes, Karin Tarte, Sandrine Boyault, Corinne Haioun, Brian K Link, Pierre Feugier, Armando Lopez-Guillermo, Hervé Tilly, Pauline Brice, Sandrine Hayette, Fabrice Jardin, Fritz Offner, Pierre Sujobert, David Gentien, Alain Viari, Elias Campo, James R Cerhan, Gilles Salles
BACKGROUND: Patients with follicular lymphoma have heterogeneous outcomes. Predictor models to distinguish, at diagnosis, between patients at high and low risk of progression are needed. The objective of this study was to use gene-expression profiling data to build and validate a predictive model of outcome for patients treated in the rituximab era. METHODS: A training set of fresh-frozen tumour biopsies was prospectively obtained from 160 untreated patients with high-tumour-burden follicular lymphoma enrolled in the phase 3 randomised PRIMA trial, in which rituximab maintenance was evaluated after rituximab plus chemotherapy induction (median follow-up 6·6 years [IQR 6·0-7·0])...
April 2018: Lancet Oncology
https://www.readbyqxmd.com/read/29473343/central-nervous-system-relapse-in-patients-over-80-years-with-diffuse-large-b-cell-lymphoma-an-analysis-of-two-lysa-studies
#18
Aurélie Cabannes-Hamy, Frederic Peyrade, Fabrice Jardin, Jean-François Emile, Vincent Delwail, Nicolas Mounier, Corinne Haioun, Aurore Perrot, Olivier Fitoussi, Diane Lara, Richard Delarue, Marc André, Fritz Offner, Hervé Ghesquières, Laurent Pascal, Carole Soussain, Julien Lazarovici, Jean-Marc Schiano, Philippe Gaulard, Hervé Tilly, Catherine Thieblemont
CNS relapse is reported in 2-5% of diffuse large B-cell lymphoma (DLBCL) patients, dramatically decreasing overall survival (OS). Very few studies address incidence and risk factors of CNS relapse in very elderly patients, a challenging population to treat given their commonly associated comorbidities. A retrospective analysis was performed of 270 DLBCL patients >80 years treated between 2004 and 2013 in two multicentre phase II LYSA trials (LNH03-7B, LNH09-7B) evaluating the addition of rituximab or ofatumumab to mini-CHOP as front-line therapy...
February 23, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29459875/decrease-in-the-photosynthetic-performance-of-temperate-grassland-species-does-not-lead-to-a-decline-in-the-gross-primary-production-of-the-ecosystem
#19
Anthony Digrado, Louis G de la Motte, Aurélie Bachy, Ahsan Mozaffar, Niels Schoon, Filippo Bussotti, Crist Amelynck, Anne-Catherine Dalcq, Marie-Laure Fauconnier, Marc Aubinet, Bernard Heinesch, Patrick du Jardin, Pierre Delaplace
Plants, under stressful conditions, can proceed to photosynthetic adjustments in order to acclimatize and alleviate the detrimental impacts on the photosynthetic apparatus. However, it is currently unclear how adjustment of photosynthetic processes under environmental constraints by plants influences CO2 gas exchange at the ecosystem-scale. Over a 2-year period, photosynthetic performance of a temperate grassland ecosystem was characterized by conducting frequent chlorophyll fluorescence (ChlF) measurements on three primary grassland species ( Lolium perenne L...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29457370/avian-metapneumovirus-subtype-c-in-wild-waterfowl-in-ontario-canada
#20
C M Jardine, E J Parmley, T Buchanan, L Nituch, D Ojkic
Avian metapneumovirus (aMPV) is an emerging poultry pathogen that has a significant economic impact on poultry production worldwide. The geographic range of the virus continues to expand, and wild birds have been implicated as reservoirs of aMPV that have the potential to spread the virus over long distances. Our objective was to determine the apparent prevalence of aMPV subtype C in wild waterfowl in Ontario, Canada. Wild waterfowl were captured in August and September, 2016 as part of routine migratory waterfowl population monitoring by the Ontario Ministry of Natural Resources and Forestry...
February 18, 2018: Transboundary and Emerging Diseases
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