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https://www.readbyqxmd.com/read/28505625/metal-artifact-reduction-on-chest-computed-tomography-examinations-comparison-of-the-iterative-metallic-artefact-reduction-algorithm-and-the-monoenergetic-approach
#1
Julien Pagniez, Louise Legrand, Suonita Khung, Jean-Baptiste Faivre, Alain Duhamel, Andreas Krauss, Jacques Remy, Martine Remy-Jardin
OBJECTIVE: The aim of the study was to compare iterative metallic artefact reduction (iMAR) and monochromatic imaging on metal artifact reduction. MATERIALS AND METHODS: Follow-up of 29 occluded pulmonary arteriovenous malformations was obtained with dual-energy computed tomography with reconstruction of averaged images using filtered back projection (group 1), iMAR (group 2), and creation of high-energy monoenergetic images (group 3). Two types of coils had been used: (a) nickel only (group A, n = 18) and (b) nickel and platinum (group B, n = 11)...
May 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28490091/physico-chemical-characterization-of-dairy-gel-obtained-by-a-proteolytic-extract-from-calotropis-procera-a-comparison-with-chymosin
#2
Issa Ado Rayanatou, ElHadji Gounga Mahamadou, Gilles Garric, Marielle Harel-Oger, Arlette Leduc, Julien Jardin, Valérie Briard-Bion, Chantal Cauty, Hassane Adakal, Jean François Grongnet, Frédéric Gaucheron
Chymosin is the major enzyme used in cheesemaking but latex enzymes are also used. The aim of this work was to characterize the composition and the structure of dairy gel obtained by an extract of Calotropis procera leaves in comparison with those obtained by chymosin. The biochemical and mineral compositions of the curds and the cheese yields obtained by using Calotropis procera extract or chymosin were relatively similar. Quantitative and qualitative evaluations of proteolysis after milk coagulation, determined by the non-protein nitrogen content and chromatography coupled to mass spectrometry, indicated that Calotropis procera extract was more proteolytic than chymosin and that κ-casein was proteolyzed...
October 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28489893/correction-novel-decay-dynamics-revealed-for-virus-mediated-drug-activation-in-cytomegalovirus-infection
#3
Jessica Rose, Vincent C Emery, Deepali Kumar, Anders Asberg, Anders Hartmann, Alan G Jardine, Angelo A Bignamini, Atul Humar, Avidan U Neumann
[This corrects the article DOI: 10.1371/journal.ppat.1006299.].
May 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28482108/psychological-distress-among-smokers-in-the-united-states-2008-to-2014
#4
Michael J Zvolensky, Charles Jardin, Melanie M Wall, Misato Gbedemah, Deborah Hasin, Stewart A Shankman, Matthew Gallagher, Jafar Bakhshaie, Renee D Goodwin
INTRODUCTION: Decline in smoking in the United States (U.S.) has slowed over the past 25 years. Mental health problems are common among smokers, and may be an impediment to quitting and remaining abstinent. The study investigated the relationship between serious (past-30-day) psychological distress (SPD) and smoking, estimated trends in the prevalence of SPD among current, former and never smokers in the U.S. from 2008 to 2014, and investigated whether heterogeneity in these trends varied by sociodemographic characteristics...
May 6, 2017: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/28481978/application-of-the-cghra-framework-to-the-genomic-characterization-of-diffuse-large-b-cell-lymphoma
#5
Sylvain Mareschal, Philippe Ruminy, Marion Alcantara, Céline Villenet, Martin Figeac, Sydney Dubois, Philippe Bertrand, Abdelilah Bouzelfen, Pierre-Julien Viailly, Dominique Penther, Hervé Tilly, Christian Bastard, Fabrice Jardin
Motivation: Although sequencing-based technologies are becoming the new reference in genome analysis, comparative genomic hybridization arrays (aCGH) still constitute a simple and reliable approach for copy number analysis. The most powerful algorithms to analyse such data have been freely provided by the scientific community for many years, but combining them is a complex scripting task. Results: The cghRA framework combines a user-friendly graphical interface and a powerful objectoriented command-line interface to handle a full aCGH analysis, as is illustrated in an original series of 107 Diffuse Large B-Cell Lymphomas...
May 8, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28479318/identification-of-somatic-mutations-in-primary-cutaneous-diffuse-large-b-cell-lymphoma-leg-type-by-massive-parallel-sequencing
#6
Sylvain Mareschal, Anne Pham-Ledard, Pierre Julien Viailly, Sydney Dubois, Philippe Bertrand, Catherine Maingonnat, Maxime Fontanilles, Elodie Bohers, Philippe Ruminy, Isabelle Tournier, Philippe Courville, Bernard Lenormand, Anne Bénédicte Duval, Emilie Andrieu, Laurence Verneuil, Beatrice Vergier, Hervé Tilly, Pascal Joly, Thierry Frebourg, Marie Beylot-Barry, Jean-Philippe Merlio, Fabrice Jardin
To determine whether the mutational profile of primary cutaneous diffuse large B-cell lymphoma leg-type (PCLBCL-LT) is unique by comparison with other diffuse large B-cell lymphoma (DLBCL) subtypes, we analyzed a total cohort of 28 PCLBCL-LT cases by next generation sequencing with a Lymphopanel designed for DLBCL. We also analyzed 12 pairs of tumor and control DNA samples by whole exome sequencing which led us to perform resequencing of three selected genes not included in the Lymphopanel: TBL1XR1, KLHL6 and IKZF3...
May 4, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28439376/-back-to-bedside-residents-and-fellows-perspectives-on-finding-meaning-in-work
#7
Dustin M Hipp, Kristy L Rialon, Kathryn Nevel, Anai N Kothari, Lcdr Dinchen A Jardine
BACKGROUND: Physician burnout is common and associated with significant consequences for physicians and patients. One mechanism to combat burnout is to enhance meaning in work. OBJECTIVE: To provide a trainee perspective on how meaning in work can be enhanced in the clinical learning environment through individual, program, and institutional efforts. METHODS: "Back to Bedside" resulted from an appreciative inquiry exercise by 37 resident and fellow members of the ACGME's Council of Review Committee Residents (CRCR), which was guided by the memoir When Breath Becomes Air by Paul Kalanithi...
April 2017: Journal of Graduate Medical Education
https://www.readbyqxmd.com/read/28434650/global-kidney-health-2017-and-beyond-a-roadmap-for-closing-gaps-in-care-research-and-policy
#8
REVIEW
Adeera Levin, Marcello Tonelli, Joseph Bonventre, Josef Coresh, Jo-Ann Donner, Agnes B Fogo, Caroline S Fox, Ron T Gansevoort, Hiddo J L Heerspink, Meg Jardine, Bertram Kasiske, Anna Köttgen, Matthias Kretzler, Andrew S Levey, Valerie A Luyckx, Ravindra Mehta, Orson Moe, Gregorio Obrador, Neesh Pannu, Chirag R Parikh, Vlado Perkovic, Carol Pollock, Peter Stenvinkel, Katherine R Tuttle, David C Wheeler, Kai-Uwe Eckardt
The global nephrology community recognises the need for a cohesive plan to address the problem of chronic kidney disease (CKD). In July, 2016, the International Society of Nephrology hosted a CKD summit of more than 85 people with diverse expertise and professional backgrounds from around the globe. The purpose was to identify and prioritise key activities for the next 5-10 years in the domains of clinical care, research, and advocacy and to create an action plan and performance framework based on ten themes: strengthen CKD surveillance; tackle major risk factors for CKD; reduce acute kidney injury-a special risk factor for CKD; enhance understanding of the genetic causes of CKD; establish better diagnostic methods in CKD; improve understanding of the natural course of CKD; assess and implement established treatment options in patients with CKD; improve management of symptoms and complications of CKD; develop novel therapeutic interventions to slow CKD progression and reduce CKD complications; and increase the quantity and quality of clinical trials in CKD...
April 20, 2017: Lancet
https://www.readbyqxmd.com/read/28434523/belatacept-where-the-benefits-outweigh-the-risk
#9
EDITORIAL
Hallvard Holdaas, Geir Mjøen, Alan G Jardine
No abstract text is available yet for this article.
May 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/28434521/scoring-risk-scores-considerations-before-incorporating-clinical-risk-prediction-tools-into-your-practice
#10
EDITORIAL
Celine Foote, Mark Woodward, Meg J Jardine
No abstract text is available yet for this article.
May 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/28430552/the-inter-association-task-force-document-on-emergency-health-and-safety-best-practice-recommendations-for-youth-sports-leagues
#11
Robert A Huggins, Samantha E Scarneo, Douglas J Casa, Luke N Belval, Kate S Carr, George Chiampas, Michael Clayton, Ryan M Curtis, A J Duffy, Alexandra Flury, Matthew Gammons, Yuri Hosokawa, John F Jardine, Cynthia R LaBella, Rachael Oats, Jack W Ransone, Scott R Sailor, Katie Scott, Rebecca L Stearns, Lesley W Vandermark, Timothy Weston
No abstract text is available yet for this article.
April 2017: Journal of Athletic Training
https://www.readbyqxmd.com/read/28430550/round-table-on-malignant-hyperthermia-in-physically-active-populations-meeting-proceedings
#12
Yuri Hosokawa, Douglas J Casa, Henry Rosenberg, John F Capacchione, Emmanuel Sagui, Sheila Riazi, Luke N Belval, Patricia A Deuster, John F Jardine, Stavros A Kavouras, Elaine C Lee, Kevin C Miller, Sheila M Muldoon, Francis G O'Connor, Scott R Sailor, Nyamkhishig Sambuughin, Rebecca L Stearns, William M Adams, Robert A Huggins, Lesley W Vandermark
CONTEXT:   Recent case reports on malignant hyperthermia (MH)-like syndrome in physically active populations indicate potential associations among MH, exertional heat stroke (EHS), and exertional rhabdomyolysis (ER). However, an expert consensus for clinicians working with these populations is lacking. OBJECTIVE:   To provide current expert consensus on the (1) definition of MH; (2) history, etiology, and pathophysiology of MH; (3) epidemiology of MH; (4) association of MH with EHS and ER; (5) identification of an MH-like syndrome; (6) recommendations for acute management of an MH-like syndrome; (7) special considerations for physically active populations; and (8) future directions for research...
April 2017: Journal of Athletic Training
https://www.readbyqxmd.com/read/28430172/ezh2-alterations-in-follicular-lymphoma-biological-and-clinical-correlations
#13
S Huet, L Xerri, B Tesson, S Mareschal, S Taix, L Mescam-Mancini, E Sohier, M Carrère, J Lazarovici, O Casasnovas, L Tonon, S Boyault, S Hayette, C Haioun, B Fabiani, A Viari, F Jardin, G Salles
The histone methyltransferase EZH2 has an essential role in the development of follicular lymphoma (FL). Recurrent gain-of-function mutations in EZH2 have been described in 25% of FL patients and induce aberrant methylation of histone H3 lysine 27 (H3K27). We evaluated the role of EZH2 genomic gains in FL biology. Using RNA sequencing, Sanger sequencing and SNP-arrays, the mutation status, copy-number and gene-expression profiles of EZH2 were assessed in a cohort of 159 FL patients from the PRIMA trial. Immunohistochemical (IHC) EZH2 expression (n=55) and H3K27 methylation (n=63) profiles were also evaluated...
April 21, 2017: Blood Cancer Journal
https://www.readbyqxmd.com/read/28428369/single-cell-rna-seq-reveals-new-types-of-human-blood-dendritic-cells-monocytes-and-progenitors
#14
Alexandra-Chloé Villani, Rahul Satija, Gary Reynolds, Siranush Sarkizova, Karthik Shekhar, James Fletcher, Morgane Griesbeck, Andrew Butler, Shiwei Zheng, Suzan Lazo, Laura Jardine, David Dixon, Emily Stephenson, Emil Nilsson, Ida Grundberg, David McDonald, Andrew Filby, Weibo Li, Philip L De Jager, Orit Rozenblatt-Rosen, Andrew A Lane, Muzlifah Haniffa, Aviv Regev, Nir Hacohen
Dendritic cells (DCs) and monocytes play a central role in pathogen sensing, phagocytosis, and antigen presentation and consist of multiple specialized subtypes. However, their identities and interrelationships are not fully understood. Using unbiased single-cell RNA sequencing (RNA-seq) of ~2400 cells, we identified six human DCs and four monocyte subtypes in human blood. Our study reveals a new DC subset that shares properties with plasmacytoid DCs (pDCs) but potently activates T cells, thus redefining pDCs; a new subdivision within the CD1C(+) subset of DCs; the relationship between blastic plasmacytoid DC neoplasia cells and healthy DCs; and circulating progenitor of conventional DCs (cDCs)...
April 21, 2017: Science
https://www.readbyqxmd.com/read/28415895/the-value-of-liquid-biopsy-in-diagnosis-and-monitoring-of-diffuse-large-b-cell-lymphoma-recent-developments-and-future-potential
#15
Vincent Camus, Fabrice Jardin, Herve Tilly
Diffuse large B-cell lymphomas (DLBCL) represent a heterogeneous subset of non-Hodgkin lymphomas (NHL) that demonstrate many molecular alterations and somatic mutations, all of which are targets for the recent development of biomarkers that use various molecular biological techniques. These non-invasive emerging biomarkers will be used in the next few years to better monitor the response to immunochemotherapeutic treatments with the aim of completely eradicating the disease in order to cure it. Areas covered: In this review, the authors conducted a literature search to identify and summarize the major advances in liquid biopsy techniques for DLBCL that are useful for diagnosis and monitoring minimal residual disease (MRD)...
April 27, 2017: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/28408815/mid-regional-pro-adrenomedullin-and-copeptin-to-predict-short-term-prognosis-of-copd-exacerbations-a-multicenter-prospective-blinded-study
#16
Martin Dres, Pierre Hausfater, Frantz Foissac, Maguy Bernard, Luc-Marie Joly, Mustapha Sebbane, Anne-Laure Philippon, Cédric Gil-Jardiné, Jeannot Schmidt, Maxime Maignan, Jean-Marc Treluyer, Nicolas Roche
BACKGROUND: Exacerbations of COPD (ECOPD) are a frequent cause of emergency room (ER) visits. Predictors of early outcome could help clinicians in orientation decisions. In the current study, we investigated whether mid-regional pro-adrenomedullin (MR-proADM) and copeptin, in addition to clinical evaluation, could predict short-term outcomes. PATIENTS AND METHODS: This prospective blinded observational study was conducted in 20 French centers. Patients admitted to the ER for an ECOPD were considered for inclusion...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28406982/novel-decay-dynamics-revealed-for-virus-mediated-drug-activation-in-cytomegalovirus-infection
#17
Jessica Rose, Vincent C Emery, Deepali Kumar, Anders Asberg, Anders Hartmann, Alan G Jardine, Angelo A Bignamini, Atul Humar, Avidan U Neumann
Human cytomegalovirus (CMV) infection is a substantial cause of morbidity and mortality in immunocompromised hosts and globally is one of the most important congenital infections. The nucleoside analogue ganciclovir (GCV), which requires initial phosphorylation by the viral UL97 kinase, is the mainstay for treatment. To date, CMV decay kinetics during GCV therapy have not been extensively investigated and its clinical implications not fully appreciated. We measured CMV DNA levels in the blood of 92 solid organ transplant recipients with CMV disease over the initial 21 days of ganciclovir therapy and identified four distinct decay patterns, including a new pattern exhibiting a transient viral rebound (Hump) following initial decline...
April 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28406170/identification-of-proteins-involved-in-the-anti-inflammatory-properties-of-propionibacterium-freudenreichii-by-means-of-a-multi-strain-study
#18
Stéphanie-Marie Deutsch, Mahendra Mariadassou, Pierre Nicolas, Sandrine Parayre, Rozenn Le Guellec, Victoria Chuat, Vincent Peton, Caroline Le Maréchal, Julien Burati, Valentin Loux, Valérie Briard-Bion, Julien Jardin, Coline Plé, Benoît Foligné, Gwénaël Jan, Hélène Falentin
Propionibacterium freudenreichii, a dairy starter, can reach a population of almost 10(9) propionibacteria per gram in Swiss-type cheese at the time of consumption. Also consumed as a probiotic, it displays strain-dependent anti-inflammatory properties mediated by surface proteins that induce IL-10 in leukocytes. We selected 23 strains with varied anti-inflammatory potentials in order to identify the protein(s) involved. After comparative genomic analysis, 12 of these strains were further analysed by surface proteomics, eight of them being further submitted to transcriptomics...
April 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28376001/equipoise-on-the-use-of-steroids-in-systemic-inflammatory-response-syndrome
#19
David Jardine
No abstract text is available yet for this article.
April 2017: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/28372152/ser2-from-serratia-liquefaciens-l53-a-new-heat-stable-protease-able-to-destabilize-uht-milk-during-its-storage
#20
François Baglinière, Gaëlle Tanguy, Rafael Locatelli Salgado, Julien Jardin, Florence Rousseau, Benoît Robert, Marielle Harel-Oger, Maria Cristina Dantas Vanetti, Frédéric Gaucheron
The heat-stable protease Ser2 is secreted by the species Serratia liquefaciens, a psychrotrophic bacteria frequently found in raw milk. To understand the physicochemical modifications of casein micelles induced by Ser2 and to confirm its implication in UHT milk destabilization, the enzyme was purified and added to microfiltered raw milk before UHT treatment. UHT milk destabilization was investigated during 90days of storage. A visual destabilization appeared after 8days of storage with the presence of sediment...
August 15, 2017: Food Chemistry
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