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Nicholas Weida, Lcdr Dinchen Jardine, Benjamin Kennedy, Amy Beane, Timothy Daskivich
BACKGROUND : Resident attitudes toward the Accreditation Council for Graduate Medical Education (ACGME) likely influence the ACGME's effectiveness in its role of ensuring compliance with its requirements. Beyond perceptions of duty hour limits and their enforcement, there is a lack of data on resident perceptions of the ACGME and its role. OBJECTIVE : We explored resident attitudes toward the ACGME and developed recommendations for improved outreach to the resident community to improve perceptions...
October 2016: Journal of Graduate Medical Education
Isabelle Le Huërou-Luron, Karima Bouzerzour, Stéphanie Ferret-Bernard, Olivia Ménard, Laurence Le Normand, Cécile Perrier, Cindy Le Bourgot, Julien Jardin, Claire Bourlieu, Thomas Carton, Pascale Le Ruyet, Isabelle Cuinet, Cécile Bonhomme, Didier Dupont
PURPOSE: Although composition of infant formula has been significantly improved during the last decade, major differences with the composition and structure of breast milk still remain and might affect nutrient digestion and gut biology. We hypothesized that the incorporation of dairy fat in infant formulas could modify their physiological impacts by making their composition closer to that of human milk. The effect of milk fat and milk fat globule membrane (MFGM) fragments in infant formulas on gut digestion, mucosal immunity and microbiota composition was evaluated...
October 15, 2016: European Journal of Nutrition
David Rizzo, Pierre-Julien Viailly, Sylvain Mareschal, Elodie Bohers, Jean-Michel Picquenot, Dominique Penther, Sydney Dubois, Vinciane Marchand, Philippe Bertrand, Catherine Maingonnat, Pascaline Etancelin, Jean Feuillard, Christian Bastard, Hervé Tilly, Fabrice Jardin, Philippe Ruminy
Little is known on the phylogenetic relationship between diagnostic and relapse clones of Diffuse Large B-Cell Lymphoma (DLBCL). We applied High Throughput Sequencing (HTS) of the VDJ locus of Immunoglobulin Heavy chain (IGHV) on fourteen DLBCL patients with serial samples, including tumor biopsies and/or peripheral blood mononuclear cells (PBMC). Phylogenetic data were consolidated with targeted sequencing and cytogenetics. Phylogeny clearly showed that DLBCL relapse could occur according either an early or a late divergent mode...
October 13, 2016: American Journal of Hematology
Lorra Garey, Charles Jardin, Brooke Y Kauffman, Carla Sharp, Clayton Neighbors, Norman B Schmidt, Michael J Zvolensky
The Barriers to Cessation Scale (BCS; Macnee & Talsma, 1995a) was developed to assess global and specific perceived barriers that may interfere with the quit process. Although the BCS is widely used in the literature, little scientific work has been devoted to examining the psychometric properties of the measure. Thus, the present study sought to address this gap by evaluating the BCS in a sample of 497 treatment-seeking smokers. The current study examined the factor structure of the BCS, measurement invariance of the BCS subscales across sex and over 2 time points, and evaluated construct validity...
August 15, 2016: Psychological Assessment
A Shankar, C L M Allan, D Smyth, D Jardine
A 73-year-old man presented with a 6-month history of exertional headaches. Exercise tolerance test demonstrated progressive ischaemic changes concomitant with worsening headache. Cardiac cephalgia was diagnosed and his symptoms resolved after coronary artery bypass surgery. Cardiac cephalgia may occasionally present as exertional headache without chest symptoms.
October 2016: Internal Medicine Journal
Daniel Jardines, Francesco Botrè, Cristiana Colamonici, Davide Curcio, Gemma Procida, Xavier de la Torre
The detection of the abuse of pseudo-endogenous steroids (testosterone and/or its precursors) is currently based on the application of the steroid module of the World Antidoping Agency (WADA), Athletes' Biological Passport (ABP), implemented through ADAMS. Diagnostic metabolites are monitored for every athlete and statistically evaluated with a predictive Bayesian approach. In the case of suspicious samples, the data of the ABP are confirmed and the isotope ratio mass spectrometry (IRMS) test is activated. We have previously demonstrated that IRMS enables confirmation of the non-endogenous origin of pseudo-endogenous steroids in otherwise non-suspicious samples, after a longitudinal evaluation of the ABP, even after the inclusion of additional long term diagnostic hydroxylated metabolites, and that the delta values of the parameters obtained during the IRMS confirmation process presented a much lesser variability compared to the parameters of the ABP...
October 12, 2016: Drug Testing and Analysis
Stewart J Wiseman, Mark E Bastin, Charlotte L Jardine, Gayle Barclay, Iona F Hamilton, Elaine Sandeman, David Hunt, E Nicole Amft, Susan Thomson, Jill F F Belch, Stuart H Ralston, Joanna M Wardlaw
BACKGROUND AND PURPOSE: Systemic lupus erythematosus (SLE) increases stroke risk, but the mechanism is uncertain. This study aimed to determine the association between SLE and features on neuroimaging of cerebral small vessel disease (SVD), a risk factor for stroke. METHODS: Consecutive patients attending a clinic for SLE were recruited. All patients underwent brain magnetic resonance imaging; had blood samples taken for markers of inflammation, endothelial dysfunction, cholesterol, and autoantibodies; and underwent cognitive and psychiatric testing...
October 4, 2016: Stroke; a Journal of Cerebral Circulation
Doreen McGough, Lynne Jardine
A number of published studies have suggested that high levels of exposure to manganese, especially those found in occupational settings, can adversely affect the reproductive system. The objective of this study was therefore to investigate if these findings can be replicated using the Sprague Dawley rat and, if so, to identify those parts of the reproductive system are more susceptible. Male and female rats were exposed to manganese dichloride (MnCl2) via inhalation at concentrations of 0 (air-control); 5, 10 and 20μg/L air over 10 weeks (F0) and over 11 weeks (F1) prior to mating, and then throughout mating, gestation and lactation until termination after the F1 and F2 generation had reached Day 21 of lactation respectively...
September 23, 2016: Neurotoxicology
Carla Sharp, Charles Jardin, Lochner Marais, Michael Boivin
While the number of new HIV infections has declined, the number of orphans as a result of AIDS-related deaths continues to increase. The aim of this paper was to systematically review empirical research on the mental health of children affected by HIV/AIDS in the developing world, specifically with an eye on developing a theoretical framework to guide intervention and research. Articles for review were gathered by following the Preferred Reporting Items for Systemic Reviews and Meta Analyses (PRISMA standards), reviewed and then organized and synthesized with a Developmental Psychopathology framework...
November 2015: Journal of HIV and AIDS
Sandra Wagner, Mugurel Apetrii, Ziad A Massy, Kleber E Marcus, Graciela E Delgado, Scharnagel Hubert, März Winfried, Marie Metzger, Patrick Rossignol, Alan Jardine, Hallvard Holdaas, Bengt Fellström, Roland Schmieder, Bénédicte Stengel, Faiez Zannad
Statin treatment reduces the risk of cardiovascular mortality in the general population, but it has little or no benefit in hemodialyzed patients (HD). This may reflect different underlying pathophysiology of CVD in patients treated with HD, maybe involving the oxidative stress. Our aim was to assess the association of oxidized LDL (oxLDL), determinated by Mercodia oxLDL ELISA Kit, with major adverse cardiac events (MACE) and all-cause mortality in HD patients based on the AURORA trial (rosuvastatin vs placebo), and patients not on HD from the LURIC study...
September 25, 2016: Free Radical Research
Joseph G Jardine, Devin Sok, Jean-Philippe Julien, Bryan Briney, Anita Sarkar, Chi-Hui Liang, Erin M Scherer, Carole J Henry Dunand, Yumiko Adachi, Devan Diwanji, Jessica Hsueh, Meaghan Jones, Oleksandr Kalyuzhniy, Michael Kubitz, Skye Spencer, Matthias Pauthner, Karen L Saye-Francisco, Fabian Sesterhenn, Patrick C Wilson, Denise A Galloway, Robyn L Stanfield, Ian A Wilson, Dennis R Burton, William R Schief
[This corrects the article DOI: 10.1371/journal.ppat.1005815.].
September 2016: PLoS Pathogens
Kristin J Bondo, David L Pearl, Nicol Janecko, Patrick Boerlin, Richard J Reid-Smith, Jane Parmley, Claire M Jardine
Salmonella has been detected in the feces of many wildlife species, including raccoons (Procyon lotor), but little is known about the epidemiology of Salmonella in wildlife living in different habitat types. Our objective was to investigate demographic, temporal, and climatic factors associated with the carriage of Salmonella in raccoons and their environment on swine farms and conservation areas. Using a repeated cross-sectional study design, we collected fecal samples from raccoons and environmental samples (soil, manure pits, dumpsters) on 5 swine farms and 5 conservation areas in Ontario, Canada once every five weeks from May to November, 2011-2013...
2016: PloS One
Amanda M MacDonald, Claire M Jardine, G Douglas Campbell, Nicole M Nemeth
Wild turkeys ( Meleagris gallopavo silvestris) were extirpated from Ontario, Canada, in the early 1900s due to unregulated over-hunting and habitat loss. Despite a successful reintroduction program and strong population numbers, information regarding the health of wild turkeys in Ontario is scarce. A 22-yr (1992-2014) retrospective study was performed to evaluate diagnostic data, including the cause(s) and contributors to death, in wild turkeys submitted to the Ontario-Nunavut node of the Canadian Wildlife Health Cooperative (n = 56)...
September 2016: Avian Diseases
Bryan Briney, Devin Sok, Joseph G Jardine, Daniel W Kulp, Patrick Skog, Sergey Menis, Ronald Jacak, Oleksandr Kalyuzhniy, Natalia de Val, Fabian Sesterhenn, Khoa M Le, Alejandra Ramos, Meaghan Jones, Karen L Saye-Francisco, Tanya R Blane, Skye Spencer, Erik Georgeson, Xiaozhen Hu, Gabriel Ozorowski, Yumiko Adachi, Michael Kubitz, Anita Sarkar, Ian A Wilson, Andrew B Ward, David Nemazee, Dennis R Burton, William R Schief
Induction of broadly neutralizing antibodies (bnAbs) is a primary goal of HIV vaccine development. VRC01-class bnAbs are important vaccine leads because their precursor B cells targeted by an engineered priming immunogen are relatively common among humans. This priming immunogen has demonstrated the ability to initiate a bnAb response in animal models, but recall and maturation toward bnAb development has not been shown. Here, we report the development of boosting immunogens designed to guide the genetic and functional maturation of previously primed VRC01-class precursors...
September 8, 2016: Cell
Gemma Currie, Alison H M Taylor, Toshiro Fujita, Hiroshi Ohtsu, Morten Lindhardt, Peter Rossing, Lene Boesby, Nicola C Edwards, Charles J Ferro, Jonathan N Townend, Anton H van den Meiracker, Mohammad G Saklayen, Sonia Oveisi, Alan G Jardine, Christian Delles, David J Preiss, Patrick B Mark
BACKGROUND: Hypertension and proteinuria are critically involved in the progression of chronic kidney disease. Despite treatment with renin angiotensin system inhibition, kidney function declines in many patients. Aldosterone excess is a risk factor for progression of kidney disease. Hyperkalaemia is a concern with the use of mineralocorticoid receptor antagonists. We aimed to determine whether the renal protective benefits of mineralocorticoid antagonists outweigh the risk of hyperkalaemia associated with this treatment in patients with chronic kidney disease...
September 8, 2016: BMC Nephrology
Devin Sok, Bryan Briney, Joseph G Jardine, Daniel W Kulp, Sergey Menis, Matthias Pauthner, Andrew Wood, E-Chiang Lee, Khoa M Le, Meaghan Jones, Alejandra Ramos, Oleksandr Kalyuzhniy, Yumiko Adachi, Michael Kubitz, Skye MacPherson, Allan Bradley, Glenn A Friedrich, William R Schief, Dennis R Burton
A major obstacle to a broadly neutralizing antibody (bnAb)-based HIV vaccine is the activation of appropriate B cell precursors. Germline-targeting immunogens must be capable of priming rare bnAb precursors in the physiological setting. We tested the ability of the VRC01-class bnAb germline-targeting immunogen eOD-GT8 60mer (60-subunit self-assembling nanoparticle) to activate appropriate precursors in mice transgenic for human immunoglobulin (Ig) loci. Despite an average frequency of, at most, about one VRC01-class precursor per mouse, we found that at least 29% of singly immunized mice produced a VRC01-class memory response, suggesting that priming generally succeeded when at least one precursor was present...
September 30, 2016: Science
Isabelle Meunier, Béatrice Bocquet, Gilles Labesse, Christina Zeitz, Sabine Defoort-Dhellemmes, Annie Lacroux, Martine Mauget-Faysse, Isabelle Drumare, Anne-Sophie Gamez, Cyril Mathieu, Virginie Marquette, Lola Sagot, Claire-Marie Dhaenens, Carl Arndt, Patrick Carroll, Martine Remy-Jardin, Salomon Yves Cohen, José-Alain Sahel, Bernard Puech, Isabelle Audo, Sarah Mrejen, Christian P Hamel
To revisit the autosomal dominant Sorsby fundus dystrophy (SFD) as a syndromic condition including late-onset pulmonary disease. We report clinical and imaging data of ten affected individuals from 2 unrelated families with SFD and carrying heterozygous TIMP3 mutations (c.572A > G, p.Y191C, exon 5, in family 1 and c.113C > G, p.S38C, exon 1, in family 2). In family 1, all SFD patients older than 50 (two generations) had also a severe emphysema, despite no history of smoking or asthma. In the preceding generation, the mother died of pulmonary emphysema and she was blind after the age of 50...
2016: Scientific Reports
Imène Felfoul, Julien Jardin, Frédéric Gaucheron, Hamadi Attia, M A Ayadi
Cow and camel milk proteins before and after heat treatment at 80°C for 60min were identified using LC/MS and LC-MS/MS following monodimensional electrophoresis. The database used for the identification of camel and cow proteins was set from The obtained results showed that, after heating, camel milk at 80°C for 60min, camel α-lactalbumin (α-la) and peptidoglycan recognition protein (PGRP) were not detected while camel serum albumin (CSA) was significantly diminished. When heating cow milk at 80°C for 60min, α-lactalbumin (α-la) and β-lactoglobulin (β-lg) were not significantly detected...
February 1, 2017: Food Chemistry
Kristian Gaarn du Jardin, Heidi Kaastrup Müller, Connie Sanchez, Gregers Wegener, Betina Elfving
Major depressive disorder (MDD) is associated with dysfunctional serotonergic and glutamatergic neurotransmission, and the genetic animal model of depression Flinders Sensitive Line (FSL) rats display alterations in these systems relatively to their control strain Flinders Resistant Line (FRL). However, changes on transcript level related to serotonergic and glutamatergic signaling have only been sparsely studied in this model. The non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist ketamine has fast-onset antidepressant properties, and recent data implicate serotonergic neurotransmission in ketamine's antidepressant-like activities in rodents...
September 2, 2016: Synapse
Amanda Venta, Charles Jardin, Allison Kalpakci, Carla Sharp
The importance of measuring attachment insecurity is underscored by a vast literature tying attachment insecurity to numerous psychological disorders. Self-report measures assess explicit attachment beliefs and experiences, while interview measures, like the Adult Attachment Interview, assess implicit internal working models about the self as worthy of care and others as reliable sources of care. The present study is a preliminary psychometric evaluation of a potentially cost-effective method of assessing implicit internal working models of attachment through the development of an Implicit Association Test (IAT)...
2016: Bulletin of the Menninger Clinic
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