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https://www.readbyqxmd.com/read/29473343/central-nervous-system-relapse-in-patients-over-80-years-with-diffuse-large-b-cell-lymphoma-an-analysis-of-two-lysa-studies
#1
Aurélie Cabannes-Hamy, Frederic Peyrade, Fabrice Jardin, Jean-François Emile, Vincent Delwail, Nicolas Mounier, Corinne Haioun, Aurore Perrot, Olivier Fitoussi, Diane Lara, Richard Delarue, Marc André, Fritz Offner, Hervé Ghesquières, Laurent Pascal, Carole Soussain, Julien Lazarovici, Jean-Marc Schiano, Philippe Gaulard, Hervé Tilly, Catherine Thieblemont
CNS relapse is reported in 2-5% of diffuse large B-cell lymphoma (DLBCL) patients, dramatically decreasing overall survival (OS). Very few studies address incidence and risk factors of CNS relapse in very elderly patients, a challenging population to treat given their commonly associated comorbidities. A retrospective analysis was performed of 270 DLBCL patients >80 years treated between 2004 and 2013 in two multicentre phase II LYSA trials (LNH03-7B, LNH09-7B) evaluating the addition of rituximab or ofatumumab to mini-CHOP as front-line therapy...
February 23, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29459875/decrease-in-the-photosynthetic-performance-of-temperate-grassland-species-does-not-lead-to-a-decline-in-the-gross-primary-production-of-the-ecosystem
#2
Anthony Digrado, Louis G de la Motte, Aurélie Bachy, Ahsan Mozaffar, Niels Schoon, Filippo Bussotti, Crist Amelynck, Anne-Catherine Dalcq, Marie-Laure Fauconnier, Marc Aubinet, Bernard Heinesch, Patrick du Jardin, Pierre Delaplace
Plants, under stressful conditions, can proceed to photosynthetic adjustments in order to acclimatize and alleviate the detrimental impacts on the photosynthetic apparatus. However, it is currently unclear how adjustment of photosynthetic processes under environmental constraints by plants influences CO2 gas exchange at the ecosystem-scale. Over a 2-year period, photosynthetic performance of a temperate grassland ecosystem was characterized by conducting frequent chlorophyll fluorescence (ChlF) measurements on three primary grassland species ( Lolium perenne L...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29457370/avian-metapneumovirus-subtype-c-in-wild-waterfowl-in-ontario-canada
#3
C M Jardine, E J Parmley, T Buchanan, L Nituch, D Ojkic
Avian metapneumovirus (aMPV) is an emerging poultry pathogen that has a significant economic impact on poultry production worldwide. The geographic range of the virus continues to expand, and wild birds have been implicated as reservoirs of aMPV that have the potential to spread the virus over long distances. Our objective was to determine the apparent prevalence of aMPV subtype C in wild waterfowl in Ontario, Canada. Wild waterfowl were captured in August and September, 2016 as part of routine migratory waterfowl population monitoring by the Ontario Ministry of Natural Resources and Forestry...
February 18, 2018: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/29451332/characterizing-the-effects-of-a-switchable-water-additive-on-the-aqueous-solubility-of-small-molecules
#4
Jesse R Vanderveen, Sarika Burra, Jialing Geng, Alexandre Goyon, Alexander Jardine, Hyejin E Shin, Tamer Andrea, Paul J Dyson, Philip G Jessop
"Switchable water" is an aqueous solution containing a water-soluble amine additive that exhibits CO 2 -switchable properties, such as large changes in ionic strength, by forming an ammonium bicarbonate salt. Switchable water has been used to reversibly "salt-out" organic compounds from water. This study explores the salting out of several compounds in switchable water when CO 2 is present and also explores the solubility of small molecules in switchable water, compared to pure water, when CO 2 is absent...
January 25, 2018: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/29427247/environmental-factors-associated-with-the-carriage-of-bacterial-pathogens-in-norway-rats
#5
Jamie L Rothenburger, Chelsea G Himsworth, Nicole M Nemeth, David L Pearl, Claire M Jardine
Worldwide, Norway rats (Rattus norvegicus) carry a number of zoonotic pathogens. Many studies have identified rat-level risk factors for pathogen carriage. The objective of this study was to examine associations between abundance, microenvironmental and weather features and Clostridium difficile, antimicrobial-resistant (AMR) Escherichia coli and methicillin-resistant Staphylococcus aureus (MRSA) carriage in urban rats. We assessed city blocks for rat abundance and 48 microenvironmental variables during a trap-removal study, then constructed 32 time-lagged temperature and precipitation variables and fitted multivariable logistic regression models...
February 9, 2018: EcoHealth
https://www.readbyqxmd.com/read/29424935/the-effect-of-extended-hours-dialysis-on-sleep-quality-in-a-randomised-trial
#6
Jin-Lan Liao, Oliver van den Broek-Best, Brendan Smyth, Daqing Hong, Kha Vo, Li Zuo, Nicholas A Gray, Christopher T Chan, Janak de Zoysa, Vlado Perkovic, Lei Jiang, Meg Jardine
BACKGROUND: Poor sleep quality is common in haemodialysis patients and associated with worse outcomes. In this pre-specified analysis, we examined the impact of extended hours haemodialysis on sleep quality. METHODS: The ACTIVE Dialysis trial randomized 200 participants to extended (≥24 hours/week) or standard (target 12-15 hours) hours haemodialysis over 12 months. Sleep quality was measured in the Kidney Disease Quality of Life Short Form 1.3 (KDQOL-SF) by overall sleep quality score (0-10, 10 = "very good") and the sleep subscale (0-100, 100 = 'best possible sleep') every three months via blinded telephone interviewer...
February 9, 2018: Nephrology
https://www.readbyqxmd.com/read/29396150/usefulness-of-ultrasound-for-the-diagnosis-of-pyogenic-flexor-tenosynovitis-a-prospective-single-center-study-of-57-cases
#7
E Jardin, M Delord, S Aubry, F Loisel, L Obert
Pyogenic flexor tenosynovitis (PFT) is a functional emergency in hand surgery; however, its diagnosis can be difficult to make. It should always be considered when a patient presents with an inflamed finger. The goal of this study was to investigate the usefulness of ultrasound in the diagnosis of early PFT. Seventy-three patients with suspected pyogenic flexor tenosynovitis were candidates for the study. Since the diagnosis of PFT was obvious in 16 patients, they were excluded from the study and immediately underwent surgery...
January 26, 2018: Hand Surgery and Rehabilitation
https://www.readbyqxmd.com/read/29395515/barriers-to-immunization-among-newcomers-a-systematic-review
#8
Lindsay Wilson, Taylor Rubens-Augustson, Malia Murphy, Cindy Jardine, Natasha Crowcroft, Charles Hui, Kumanan Wilson
INTRODUCTION: Currently, there is a lack of comprehensive evidence exploring vaccine decision-making among newcomers. We conducted a systematic review of qualitative studies aimed at identifying factors that influence newcomers' decision-making with regards to vaccination. METHODS: We conducted a search of MEDLINE, EMBASE, CINAHL and Cochrane Central. To be included, studies needed to employ a qualitative methodology and address newcomer attitudes, beliefs, and/or perceptions regarding vaccination...
January 21, 2018: Vaccine
https://www.readbyqxmd.com/read/29392897/long-and-short-term-outcomes-in-renal-allografts-with-deceased-donors-a-large-recipient-and-donor-genome-wide-association-study
#9
Maria P Hernandez-Fuentes, Christopher Franklin, Irene Rebollo-Mesa, Jennifer Mollon, Florence Delaney, Esperanza Perucha, Caragh Stapleton, Richard Borrows, Catherine Byrne, Gianpiero Cavalleri, Brendan Clarke, Menna Clatworthy, John Feehally, Susan Fuggle, Sarah A Gagliano, Sian Griffin, Abdul Hammad, Robert Higgins, Alan Jardine, Mary Keogan, Timothy Leach, Iain MacPhee, Patrick B Mark, James Marsh, Peter Maxwell, William McKane, Adam McLean, Charles Newstead, Titus Augustine, Paul Phelan, Steve Powis, Peter Rowe, Neil Sheerin, Ellen Solomon, Henry Stephens, Raj Thuraisingham, Richard Trembath, Peter Topham, Robert Vaughan, Steven H Sacks, Peter Conlon, Gerhard Opelz, Nicole Soranzo, Michael E Weale, Graham M Lord
Improvements in immunosuppression have modified short-term survival of deceased-donor allografts, but not their rate of long-term failure. Mismatches between donor and recipient HLA play an important role in the acute and chronic allogeneic immune response against the graft. Perfect matching at clinically relevant HLA loci does not obviate the need for immunosuppression, suggesting that additional genetic variation plays a critical role in both short- and long-term graft outcomes. By combining patient data and samples from supranational cohorts across the United Kingdom and European Union, we performed the first large-scale genome-wide association study analyzing both donor and recipient DNA in 2094 complete renal transplant-pairs with replication in 5866 complete pairs...
February 1, 2018: American Journal of Transplantation
https://www.readbyqxmd.com/read/29386783/effect-of-human-dentin-albumin-and-lipopolysaccharide-on-the-antibacteerial-activity-of-endodontic-activity-of-endodontic-irrigants
#10
Ramiro Martins Quintana, Alexander Pompermayer Jardine, Francisco Montagner, Clarissa Cavalcanti Fatturi Parolo, Renata Dornelles Morgental, Patrícia Maria Poli Kopper
Context: Human dentin powder (HD), bovine serum albumin (BSA) and endotoxin (LPS) may affect the antimicrobial activity of irrigating solutions. Aim: To evaluate the inhibitory effect of HD powder, BSA, and LPS on the antibacterial activity of 0.5%, 1%, 2.5%, and 5% sodium hypochlorite (NaOCl), 2% chlorhexidine (CHX) gel, BioPure mixture of tetracycline, citric acid, and detergent (MTAD), and QMix. Methods: The direct contact test against Enterococcus faecalis (ATCC 29212) for 2-min, 30-min and 6-h was used...
September 2017: Journal of Conservative Dentistry: JCD
https://www.readbyqxmd.com/read/29386654/body-size-is-more-important-than-diet-in-determining%C3%A2-stable-isotope-estimates-of-trophic-position-in-crocodilians
#11
Francisco Villamarín, Timothy D Jardine, Stuart E Bunn, Boris Marioni, William E Magnusson
The trophic position of a top predator, synonymous with food-chain length, is one of the most fundamental attributes of ecosystems. Stable isotope ratios of nitrogen (δ15N) have been used to estimate trophic position of organisms due to the predictable enrichment of 15N in consumer tissues relative to their diet. Previous studies in crocodilians have found upward ontogenetic shifts in their 'trophic position'. However, such increases are not expected from what is known about crocodilian diets because ontogenetic shifts in diet relate to taxonomic categories of prey rather than shifts to prey from higher trophic levels...
January 31, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29382971/livestock-associated-methicillin-resistant-staphylococcus-aureus-and-clostridium-difficile-in-wild-norway-rats-rattus-norvegicus-from-ontario-swine-farms
#12
Jamie L Rothenburger, Joyce D Rousseau, J Scott Weese, Claire M Jardine
Methicillin-resistant Staphylococcus aureus (MRSA) and Clostridium difficile are important human pathogens that are also carried by animals. The role of wild mammals on farms in their maintenance and transmission, however, is poorly understood. To determine if Norway rats (Rattus norvegicus) are potential carriers of these bacteria on Canadian farms, we tested 21 rats from swine farms in Ontario. The MRSA spa type t034 was isolated from 1 (4.8%) rat. This livestock-associated strain often colonizes pigs and pig farmers, suggesting that transmission among rats and pigs or environmental transmission is possible on pig farms...
January 2018: Canadian Journal of Veterinary Research, Revue Canadienne de Recherche Vétérinaire
https://www.readbyqxmd.com/read/29351826/nonadherence-to-cpap-associated-with-increased-30-day-hospital-readmissions
#13
Kimberly K Truong, Rossi De Jardin, Nahal Massoudi, Mehrtash Hashemzadeh, Behrouz Jafari
STUDY OBJECTIVES: The primary objective of this study was to determine if nonadherence to continuous positive airway pressure (CPAP) is associated with increased 30-day all-cause, cardiovascular-cause, and pulmonary-cause hospital readmissions. METHODS: Retrospective cohort study at a Veterans Affairs hospital of patients with obstructive sleep apnea (OSA) who were hospitalized from January 1, 2007 to December 31, 2015. Odds ratio of 30-day readmission was calculated for all-cause, cardiovascular-cause, and pulmonary-cause readmissions...
January 16, 2018: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/29344718/combination-of-baseline-fdg-pet-ct-total-metabolic-tumour-volume-and-gene-expression-profile-have-a-robust-predictive-value-in-patients-with-diffuse-large-b-cell-lymphoma
#14
Mathieu Nessim Toledano, P Desbordes, A Banjar, I Gardin, P Vera, P Ruminy, F Jardin, H Tilly, S Becker
PURPOSE: This study evaluated the predictive significance of total metabolic tumour volume (TMTV) measured on baseline FDG PET/CT and its value in addition to gene expression profiling using a new method of gene analysis (rapid reverse transcriptase multiplex ligation-dependent probe amplification assay, RT-MLPA) in patients with diffuse large B-cell lymphoma treated with R-CHOP or R-CHOP-like chemotherapies. METHODS: The analysis included 114 patients. TMTV was measured using a 41% SUVmax threshold and tumours were classified into GCB or ABC subtypes according to the RT-MLPA assay...
January 17, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29338000/progression-of-the-first-stage-of-spontaneous-labour-a-prospective-cohort-study-in-two-sub-saharan-african-countries
#15
Olufemi T Oladapo, Joao Paulo Souza, Bukola Fawole, Kidza Mugerwa, Gleici Perdoná, Domingos Alves, Hayala Souza, Rodrigo Reis, Livia Oliveira-Ciabati, Alexandre Maiorano, Adesina Akintan, Francis E Alu, Lawal Oyeneyin, Amos Adebayo, Josaphat Byamugisha, Miriam Nakalembe, Hadiza A Idris, Ola Okike, Fernando Althabe, Vanora Hundley, France Donnay, Robert Pattinson, Harshadkumar C Sanghvi, Jen E Jardine, Özge Tunçalp, Joshua P Vogel, Mary Ellen Stanton, Meghan Bohren, Jun Zhang, Tina Lavender, Jerker Liljestrand, Petra Ten Hoope-Bender, Matthews Mathai, Rajiv Bahl, A Metin Gülmezoglu
BACKGROUND: Escalation in the global rates of labour interventions, particularly cesarean section and oxytocin augmentation, has renewed interest in a better understanding of natural labour progression. Methodological advancements in statistical and computational techniques addressing the limitations of pioneer studies have led to novel findings and triggered a re-evaluation of current labour practices. As part of the World Health Organization's Better Outcomes in Labour Difficulty (BOLD) project, which aimed to develop a new labour monitoring-to-action tool, we examined the patterns of labour progression as depicted by cervical dilatation over time in a cohort of women in Nigeria and Uganda who gave birth vaginally following a spontaneous labour onset...
January 2018: PLoS Medicine
https://www.readbyqxmd.com/read/29336710/consensus-statement-prehospital-care-of-exertional-heat-stroke
#16
Luke N Belval, Douglas J Casa, William M Adams, George T Chiampas, Jolie C Holschen, Yuri Hosokawa, John Jardine, Shawn F Kane, Michele Labotz, Renée S Lemieux, Kyle B McClaine, Nathaniel S Nye, Francis G O'Connor, Bryan Prine, Neha P Raukar, Michael S Smith, Rebecca L Stearns
Exertional heat stroke (EHS) is one of the most common causes of sudden death in athletes. It also represents a unique medical challenge to the prehospital healthcare provider due to the time sensitive nature of treatment. In cases of EHS, when cooling is delayed, there is a significant increase in organ damage, morbidity, and mortality after 30 minutes, faster than the average EMS transport and ED evaluation window. The purpose of this document is to present a paradigm for prehospital healthcare systems to minimize the risk of morbidity and mortality for EHS patients...
January 16, 2018: Prehospital Emergency Care
https://www.readbyqxmd.com/read/29321218/non-uniform-relationship-between-salt-status-and-aldosterone-activity-in-patients-with-chronic-kidney-disease
#17
Alison H M Taylor, Alastair J Rankin, Emily P McQuarrie, E Marie Freel, Natalie Z M Homer, Ruth Andrew, Alan G Jardine, Patrick B Mark
BACKGROUND: Hypertension is prevalent in chronic kidney disease (CKD). Studies suggest that reduction in dietary salt intake reduces blood pressure (BP). We studied relationships between salt intake, BP and renin-angiotensin system regulation in order to establish if it is disordered in CKD. METHODS: Mechanistic crossover study of CKD patients versus non-CKD controls. Participants underwent modified saline suppression test prior to randomization to either low or high salt diet for 5 days and then crossed over to the alternate diet...
January 31, 2018: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29319561/an-evaluation-of-educational-neurological-eye-movement-disorder-video-posted-on-internet-video-sharing-sites-comment
#18
Griffin Jardine, Nancy T Lombardo, Christy Jarvis, Kathleen Digre
No abstract text is available yet for this article.
March 2018: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/29296835/mutation-load-and-an-effector-t-cell-gene-signature-may-distinguish-immunologically-distinct-and-clinically-relevant-lymphoma-subsets
#19
Christopher R Bolen, Ronald McCord, Sarah Huet, Garrett M Frampton, Richard Bourgon, Fabrice Jardin, Peggy Dartigues, Elizabeth A Punnoose, Edith Szafer-Glusman, Luc Xerri, Pierre Sujobert, Gilles Salles, Jeffrey M Venstrom
Identifying follicular lymphoma (FL) patients with preexisting antitumor immunity will inform precision medicine strategies for novel cancer immunotherapies. Using clinical and genomic data from 249 FL patients, we determined the clinical impact of mutation load and an effector T-cell (Teff) gene signature as proxies for the likelihood of a functional immune response. The FL mutation load estimate varied between 0 and 33 mutations per Mb (median, 6.6), and 92% of FL patients with a high mutation load had high Teff gene expression (P = ...
October 10, 2017: Blood Advances
https://www.readbyqxmd.com/read/29284605/filamin-a-modulates-store-operated-ca2-entry-by-regulating-stim1-stromal-interaction-molecule-1-orai1-association-in-human-platelets
#20
Jose J Lopez, Letizia Albarrán, Isaac Jardín, Jose Sanchez-Collado, Pedro C Redondo, Nuria Bermejo, Regis Bobe, Tarik Smani, Juan A Rosado
OBJECTIVE: Here, we provide evidence for the role of FLNA (filamin A) in the modulation of store-operated calcium entry (SOCE). APPROACH AND RESULTS: SOCE is a major mechanism for calcium influx controlled by the intracellular Ca2+ stores. On store depletion, the endoplasmic reticulum calcium sensor STIM1 (stromal interaction molecule 1) redistributes into puncta at endoplasmic reticulum/plasma membrane junctions, a process supported by the cytoskeleton, where it interacts with the calcium channels; however, the mechanism for fine-tuning SOCE is not completely understood...
December 28, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
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