Read by QxMD icon Read


T Jardin, T Colonius
Lentink & Dickinson (2009 J. Exp. Biol. 212 , 2705-2719. (doi:10.1242/jeb.022269)) showed that rotational acceleration stabilized the leading-edge vortex on revolving, low aspect ratio (AR) wings and hypothesized that a Rossby number of around 3, which is achieved during each half-stroke for a variety of hovering insects, seeds and birds, represents a convergent high-lift solution across a range of scales in nature. Subsequent work has verified that, in particular, the Coriolis acceleration plays a key role in LEV stabilization...
June 2018: Journal of the Royal Society, Interface
Emma O'Lone, Andrea K Viecelli, Jonathan C Craig, Allison Tong, Benedicte Sautenet, David Roy, William G Herrington, Charles A Herzog, Tazeen Jafar, Meg Jardine, Vera Krane, Adeera Levin, Jolanta Malyszko, Michael V Rocco, Giovanni Strippoli, Marcello Tonelli, Angela Yee Moon Wang, Christoph Wanner, Faiez Zannad, Wolfgang C Winkelmayer, Angela C Webster, David C Wheeler
Patients on long-term hemodialysis are at very high risk for cardiovascular disease but are usually excluded from clinical trials conducted in the general population or in at-risk populations. There are no universally agreed cardiovascular outcomes for trials conducted specifically in the hemodialysis population. In this review, we highlight that trials reporting cardiovascular outcomes in hemodialysis patients are usually of short duration (median 3 to 6 months) and are small (59% of trials have <100 participants)...
June 19, 2018: Journal of the American College of Cardiology
P Scardi, M Ermrich, A Fitch, E-Wen Huang, R Jardin, R Kuzel, A Leineweber, A Mendoza Cuevas, S T Misture, L Rebuffi, Christian Schimpf
Separation of size and strain effects on diffraction line profiles has been studied in a round robin involving laboratory instruments and synchrotron radiation beamlines operating with different radiation, optics, detectors and experimental configurations. The studied sample, an extensively ball milled iron alloy powder, provides an ideal test case, as domain size broadening and strain broadening are of comparable size. The high energy available at some synchrotron radiation beamlines provides the best conditions for an accurate analysis of the line profiles, as the size-strain separation clearly benefits from a large number of Bragg peaks in the pattern; high counts, reliable intensity values in low-absorption conditions, smooth background and data collection at different temperatures also support the possibility to include diffuse scattering in the analysis, for the most reliable assessment of the line broadening effect...
June 1, 2018: Journal of Applied Crystallography
Elena Marcassa, Andreas Kallinos, Jane Jardine, Emma V Rusilowicz-Jones, Aitor Martinez, Sandra Kuehl, Markus Islinger, Michael J Clague, Sylvie Urbé
USP30 is an integral protein of the outer mitochondrial membrane that counteracts PINK1 and Parkin-dependent mitophagy following acute mitochondrial depolarisation. Here, we use two distinct mitophagy reporter systems to reveal tonic suppression by USP30, of a PINK1-dependent component of basal mitophagy in cells lacking detectable Parkin. We propose that USP30 acts upstream of PINK1 through modulation of PINK1-substrate availability and thereby determines the potential for mitophagy initiation. We further show that a fraction of endogenous USP30 is independently targeted to peroxisomes where it regulates basal pexophagy in a PINK1- and Parkin-independent manner...
June 12, 2018: EMBO Reports
Cédric Gil-Jardiné, Grégoire Evrard, Samantha Al Joboory, Juliane Tortes Saint Jammes, Françoise Masson, Régis Ribéreau-Gayon, Michel Galinski, Louis-Rachid Salmi, Philippe Revel, Cyril Alexandre Régis, Guillaume Valdenaire, Emmanuel Lagarde
Up to 20% of patients presenting at an emergency room (ER) after a stressful event will for several months suffer from very diverse long-lasting symptoms and a potentially significant decline in quality of life, often described as post concussion-like symptoms (PCLS). The objectives of our randomized open-label single-center study were to assess the feasibility of psychologist-led interventions in the context of the ER and to compare the effect of eye movement desensitization and reprocessing (EMDR) with reassurance and usual care...
May 26, 2018: Journal of Psychiatric Research
Shakeela Sayed, Tatiana Millard, Anwar Jardine
Chitin and chitosan play an important role in the context of a biorefinery where waste is converted into useful products. The introduction of an amine at the C-6 position of chitosan has led to the synthesis of a water-soluble chitosan derivative, 6-deoxy-6-amino chitosan. However, all known synthetic methods for the synthesis of 6-deoxy-6-amino chitosan have some limitations, which acts as impediments to the scale up process and ultimately exploitation. The solubility of the polymer in water is advantageous and opens many different avenues of application...
September 15, 2018: Carbohydrate Polymers
Sonomi Maruyama, Chia-Ling Wu, Sumiko Yoshida, Dongying Zhang, Pei-Hsuan Li, Fangzhou Wu, Jennifer Parker Duffen, Rouan Yao, Blake Jardin, Ibrahim M Adham, Ronald Law, Joel Berger, Richard Di Marchi, Kenneth Walsh
BACKGROUND: The insulin/insulin-like growth factor/relaxin family represents a group of structurally related but functionally diverse proteins. The family member relaxin-2 has been evaluated in clinical trials for its efficacy in the treatment of acute heart failure. In this study, we assessed the role of insulin-like peptide 6 (INSL6), another member of this protein family, in murine heart failure models using genetic loss-of-function and protein delivery methods. METHODS AND RESULTS: Insl6-deficient and wild-type (C57BL/6N) mice were administered angiotensin II or isoproterenol via continuous infusion with an osmotic pump or via intraperitoneal injection once a day, respectively, for 2 weeks...
June 10, 2018: Journal of the American Heart Association
Andrew H Rogers, Charles Jardin, Nubia A Mayorga, Jafar Bakhshaie, Amy Leonard, Chad Lemaire, Michael J Zvolensky
Men who have sex with men (MSM) are at high risk for contraction and transmission of Human Immunodeficiency Virus (HIV). Increased risk of infection has been linked to high risk behaviors, such as alcohol and drug use, as well as engaging in unsafe sexual behaviors. Experiences of discrimination related to sexual orientation often experienced in this population predict risky behavior outcomes, but little research has examined the mechanisms implicated in this model. The current study examined the effect of anxiety and depressive symptoms in the relationship between discrimination related to sexual orientation and high-risk behaviors of alcohol use, drug use, using sex to cope with negative emotions, frequency of sex without a condom, and frequency of sex with an HIV+ or unknown status partner...
May 30, 2018: Psychiatry Research
Maria Fernanda Adame, Timothy D Jardine, Brian Fry, Dominic Valdez, Garry Lindner, Jonathan Nadji, Stuart E Bunn
The estuarine crocodile (Crocodylus porosus) is one of the largest and most widespread crocodilians in the world. Although considered an apex species, the role of the estuarine crocodile in aquatic foodwebs is poorly understood; we know what crocodiles ingest, but not what nourishes them. In this study, we used a combination of stable isotope measurements (δ13C, δ15N, and δ34S) and direct feeding observations to identify the source of nutrition of estuarine crocodiles in Kakadu National Park, Northern Australia...
2018: PloS One
Christophe Boudesco, Els Verhoeyen, Laurent Martin, Catherine Chassagne-Clement, Leila Salmi, Rana Mhaidly, Céline Pangault, Thierry Fest, Selim Ramla, Fabrice Jardin, Olaf-Oliver Wolz, Alexander N R Weber, Carmen Garrido, Gaetan Jego
Activated B cell diffuse large B cell lymphoma (ABC-DLBCL) is an aggressive lymphoproliferative disorder involving chronic NF-κB activation. Several mutations in the BCR and the MyD88 signaling pathway components, such as MyD88 L265P, are implicated in this aberrant activation. Among heat-shock proteins, HSP110 has recently been identified as a pro- survival and/or proliferation factor in many cancers but its role in ABC-DLBCL survival mechanisms remained to be established. We observed that shRNA-mediated HSP110 silencing decreased the survival of several ABC-DLBCL cell lines, decreased IgM-MyD88 co-localization and subsequent NF-κB signaling...
June 5, 2018: Blood
Kathryn Smith, Paul T Oesterle, Claire M Jardine, Antonia Dibernardo, Chris Huynh, Robbin Lindsay, David L Pearl, Angela M Bosco-Lauth, Nicole M Nemeth
Powassan virus (POWV) is a tick-borne zoonosis maintained in natural enzootic cycles between ixodid ticks and wild mammals. Reported human cases have increased in recent years; these infections can be fatal or lead to long-term neurologic sequelae. However, both the geographic distribution and the role of common, potential mammalian hosts in POWV transmission are poorly understood, creating challenges to public health surveillance. We looked for evidence of POWV infection among candidate wildlife host species and ticks collected from mammals and birds in southern Ontario...
June 4, 2018: American Journal of Tropical Medicine and Hygiene
Aurélie Manchuelle, François Pontana, Pascal De Groote, Paul Lebert, Marie Fertin, Marine Baijot, Christopher Hurt, Nicolas Lamblin, Nicolas Debry, Guillaume Schurtz, Anju Duva Pentiah, Arnaud Sudre, Martine Remy-Jardin, Patrizio Lancellotti, Eric Van Belle, Christophe Bauters, Gilles Lemesle, Cédric Delhaye
BACKGROUND: Coronary artery disease (CAD) is the leading cause of systolic heart failure (HF). Cardiac magnetic resonance imaging (CMR) is a non-invasive technique that detects a myocardial infarction scar as subendocardial or transmural late gadolinium enhancement (st-LGE). AIM: We sought to evaluate whether a lack of st-LGE could rule out CAD in new-onset systolic HF of unknown aetiology. METHODS: We included 232 consecutive patients with new-onset HF and left ventricular ejection fraction ≤35% who underwent both coronary angiography and CMR to assess HF aetiology...
May 31, 2018: Archives of Cardiovascular Diseases
Matthieu Masy, Jessica Giordano, Grégory Petyt, Claude Hossein-Foucher, Alain Duhamel, Maeva Kyheng, Pascal De Groote, Marie Fertin, Nicolas Lamblin, Jean-François Bervar, Jacques Remy, Martine Remy-Jardin
OBJECTIVES: To evaluate the concordance between DECT perfusion and ventilation/perfusion (V/Q) scintigraphy in diagnosing chronic thromboembolic pulmonary hypertension (CTEPH). METHODS: Eighty patients underwent V/Q scintigraphy and DECT perfusion on a 2nd- and 3rd-generation dual-source CT system. The imaging criteria for diagnosing CTEPH relied on at least one segmental triangular perfusion defect on DECT perfusion studies and V/Q mismatch on scintigraphy examinations...
May 30, 2018: European Radiology
Daniel J Paulus, Lorra Garey, Matthew W Gallagher, Jaye L Derrick, Charles Jardin, Kirsten Langdon, Joseph W Ditre, Michael J Zvolensky
BACKGROUND: Past work has documented bidirectional associations between pain and cigarette smoking behaviors such that those who smoke evidence greater pain, and those in pain tend to smoke more. However, such work has not focused on the role of pain in relation to negative affect, which plays an important role during cessation attempts. OBJECTIVE: The current study evaluated pain as a predictor of negative affect as well as level of interference associated with negative affect among individuals undergoing a self-guided quit attempt...
May 30, 2018: American Journal of Drug and Alcohol Abuse
Pierre Decazes, Stéphanie Becker, Mathieu Nessim Toledano, Pierre Vera, Paul Desbordes, Fabrice Jardin, Hervé Tilly, Isabelle Gardin
A unit error concerning the tumor volume surface ratio (TVSR) is present throughout the article. The unit reported is "cm" but is actually "mm".
May 26, 2018: European Journal of Nuclear Medicine and Molecular Imaging
Sydney Dubois, Fabrice Jardin
No abstract text is available yet for this article.
May 22, 2018: Nature Reviews. Clinical Oncology
Monica L Elliott, Elizabeth A Des Jardin, Johana V Ortiz, Tommy Macias
Ganoderma zonatum is a lethal pathogen of palms (Arecaceae) in Florida (USA) because it degrades the wood of the lowest section of the palm trunk. This fungus is widespread throughout Florida, where it has been observed on over 60 species of palms. The authors examined the genetic variability of 25 isolates of G. zonatum obtained in Florida from 12 different palm species and representing 17 unique property locations in eight counties to determine if G. zonatum represents a species complex. The three genomic regions examined were the nuc rDNA ITS1-5...
March 2, 2018: Mycologia
Miguel Martínez-Jardines, Emmanuel Pérez-Alfaro, R O González-Robles, Anne-Claire Texier, Flor Cuervo-López
The metabolic and kinetic behaviour of a nitrification process in presence of 2-chlorophenol (2-CP) was evaluated in two sequencing batch reactors (SBR1, SBR2) inoculated with nitrifying sludge previously exposed to phenolic compounds. The SBR1 was inoculated with sludge previously exposed to 2-CP, while the SBR2 was inoculated with sludge previously exposed to p-cresol. An inhibitory effect of 20 mg 2-CP-C/L on both nitrification processes was observed, as specific rates decreased according to a control assay in absence of 2-CP...
May 14, 2018: Environmental Technology
Charline S Boente, Griffin J Jardine, Tina G Damarjian, Derek T Sprunger, Gavin J Roberts, Daniel E Neely, Kathryn M Haider, David A Plager
PURPOSE: To evaluate the use of immediate postoperative alignment measurements as a predictor of future alignment stability in fixed suture strabismus surgery. METHODS: Forty-seven patients were prospectively evaluated after undergoing horizontal or vertical rectus muscle surgery using a fixed suture technique. Alignment measurements were taken approximately 1 hour, 1 to 3 weeks, and 2 to 3 months postoperatively. A Spearman correlation coefficient was used to compare measurements from the immediate postoperative period to the 2- to 3-month postoperative period...
April 27, 2018: Journal of Pediatric Ophthalmology and Strabismus
Pierre Decazes, Stéphanie Becker, Mathieu Nessim Toledano, Pierre Vera, Paul Desbordes, Fabrice Jardin, Hervé Tilly, Isabelle Gardin
INTRODUCTION: Our aim was to study the prognostic value of two new 18 F-FDG PET biomarkers in diffuse large B-cell lymphoma (DLBCL). We examined the total tumor surface (TTS), describing the tumor-host interface, and the tumor volume surface ratio (TVSR), corresponding to the ratio between the total metabolic tumor volume (TMTV) and TTS, describing the tumor fragmentation. METHODS: We retrospectively included 215 patients with DLBCL. Patients underwent initial 18 F-FDG PET/CT before R-CHOP (73%) or intensified R-CHOP (R-ACVBP) regimens (27%)...
April 28, 2018: European Journal of Nuclear Medicine and Molecular Imaging
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"