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https://www.readbyqxmd.com/read/28222710/predicting-medical-students-who-will-have-difficulty-during-their-clinical-training
#1
D L Jardine, J M McKenzie, T J Wilkinson
BACKGROUND: We aimed to classify the difficulties students had passing their clinical attachments, and explore factors which might predict these problems. METHODS: We analysed data from regular student progress meetings 2008-2012. Problem categories were: medical knowledge, professional behaviour and clinical skills. For each category we then undertook a predictive risk analysis. RESULTS: Out of 561 students, 203 were found to have one or more problem category and so were defined as having difficulties...
February 21, 2017: BMC Medical Education
https://www.readbyqxmd.com/read/28212937/the-impact-of-alemtuzumab-scheduling-on-graft-versus-host-disease-following-unrelated-donor-fludarabine-and-melphalan-allografts
#2
Kile Green, Kim Pearce, Rob S Sellar, Laura Jardine, Phillip Lr Nicolson, Sandeep Nagra, Venetia Bigley, Graham Jackson, Anne M Dickinson, Kirsty Thomson, Stephen Mackinnon, Charles Craddock, Karl S Peggs, Matthew Collin
Alemtuzumab conditioning is highly effective at reducing the incidence of acute and chronic graft versus host disease (GVHD) in reduced intensity fludarabine and melphalan transplantation with ciclosporin monotherapy. Less frequent and lower dose scheduling may be used with sibling donors but an optimal regimen for matched unrelated donors has not been defined. In this retrospective observational study of 313 patients, the incidence and severity of GVHD was compared in patients receiving three different dose schedules: the standard 100mg regimen (20mg on day -7 to -3), 60mg (30mg day -4 and -2) or 50mg (10mg on day -7 to -3)...
February 14, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28196522/xpo1-in-b-cell-hematological-malignancies-from-recurrent-somatic-mutations-to-targeted-therapy
#3
REVIEW
Vincent Camus, Hadjer Miloudi, Antoine Taly, Brigitte Sola, Fabrice Jardin
Many recent publications highlight the large role of the pivotal eukaryotic nuclear export protein exportin-1 (XPO1) in the oncogenesis of several malignancies, and there is emerging evidence that XPO1 inhibition is a key target against cancer. The clinical validation of the pharmacological inhibition of XPO1 was recently achieved with the development of the selective inhibitor of nuclear export compounds, displaying an interesting anti-tumor activity in patients with massive pre-treated hematological malignancies...
February 14, 2017: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/28190573/stable-sulfur-isotopes-identify-habitat-specific-foraging-and-mercury-exposure-in-a-highly-mobile-fish-community
#4
Meghan K Carr, Timothy D Jardine, Lorne E Doig, Paul D Jones, Lalita Bharadwaj, Brett Tendler, John Chételat, Pete Cott, Karl-Erich Lindenschmidt
Tracking the uptake and transfer of toxic chemicals, such as mercury (Hg), in aquatic systems is challenging when many top predators are highly mobile and may therefore be exposed to chemicals in areas other than their location of capture, confounding interpretation of bioaccumulation trends. Here we show how the application of a less commonly used ecological tracer, stable sulfur isotope ratios ((34)S/(32)S, or δ(34)S), in a large river-delta-lake complex in northern Canada allows differentiation of resident from migrant fishes, beyond what was possible with more conventional (13)C/(12)C and (15)N/(14)N measurements...
February 10, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28165579/a-national-appraisal-of-haemodialysis-vascular-access-provision-in-scotland
#5
Scott W Oliver, Jacqueline Campbell, David B Kingsmore, Ram Kasthuri, Wendy Metcalfe, Jamie P Traynor, Denis Fischbacher-Smith, Alan G Jardine, Peter C Thomson
PURPOSE: Published registry data demonstrate longstanding variation in the utilisation of different vascular access (VA) modalities between Scottish renal units; this may reflect different clinical processes between centres. A comprehensive appraisal was undertaken to understand the processes underpinning VA creation and maintenance across Scotland. METHODS: A mixed methods approach was utilised. Fifty-two semi-structured interviews were conducted with patients and clinicians in all ten, adult and paediatric, Scottish renal units...
January 31, 2017: Journal of Vascular Access
https://www.readbyqxmd.com/read/28152114/left-sided-facial-pain-fullness-and-trismus
#6
Andrew G Woodhouse, Dinchen A Jardine, Allen O Mitchell
No abstract text is available yet for this article.
February 2, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28151412/a-trial-of-extending-hemodialysis-hours-and-quality-of-life
#7
Meg J Jardine, Li Zuo, Nicholas A Gray, Janak R de Zoysa, Christopher T Chan, Martin P Gallagher, Helen Monaghan, Stuart M Grieve, Rajesh Puranik, Hongli Lin, Josette M Eris, Ling Zhang, Jinsheng Xu, Kirsten Howard, Serigne Lo, Alan Cass, Vlado Perkovic
The relationship between increased hemodialysis hours and patient outcomes remains unclear. We randomized (1:1) 200 adult recipients of standard maintenance hemodialysis from in-center and home-based hemodialysis programs to extended weekly (≥24 hours) or standard (target 12-15 hours, maximum 18 hours) hemodialysis hours for 12 months. The primary outcome was change in quality of life from baseline assessed by the EuroQol 5 dimension instrument (3 level) (EQ-5D). Secondary outcomes included medication usage, clinical laboratory values, vascular access events, and change in left ventricular mass index...
February 1, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/28126705/we-need-to-talk-about-depression-and-dialysis-but-what-questions-should-we-ask-and-does-anyone-know-the-answers
#8
EDITORIAL
Maree L Hackett, Meg J Jardine
No abstract text is available yet for this article.
February 7, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/28125449/advancing-transplantation-new-questions-new-possibilities-in-kidney-and-liver-transplantation
#9
Jonas Wadström, Bo-Göran Ericzon, Philip F Halloran, Wolf O Bechstein, Gerhard Opelz, Daniel Serón, Josep Grinyó, Alexandre Loupy, Dirk Kuypers, Christophe Mariat, Marc Clancy, Alan G Jardine, Lluís Guirado, Bengt Fellström, John O'Grady, Jacques Pirenne, Jacqueline G O'Leary, Varuna Aluvihare, Pavel Trunečka, Umberto Baccarani, James Neuberger, Alejandro Soto-Gutierrez, Edward K Geissler, Monty Metzger, Muir Gray
No abstract text is available yet for this article.
February 2017: Transplantation
https://www.readbyqxmd.com/read/28100453/mechanisms-of-vasovagal-syncope-in-the-young-reduced-systemic-vascular-resistance-versus-reduced-cardiac-output
#10
Julian M Stewart, Marvin S Medow, Richard Sutton, Paul Visintainer, David L Jardine, Wouter Wieling
BACKGROUND: Syncope is a sudden transient loss of consciousness and postural tone caused by cerebral hypoperfusion. The most common form is vasovagal syncope (VVS). Presyncopal progressive early hypotension in older VVS patients is caused by reduced cardiac output (CO); younger patients have reduced systemic vascular resistance (SVR). Using a priori criteria for reduced CO (↓CO) and SVR (↓SVR), we studied 48 recurrent young fainters comparing subgroups of VVS with VVS-↓CO, VVS-↓SVR, and both VVS-↓CO&↓SVR...
January 18, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28099848/biophysical-attributes-of-cpg-presentation-control-tlr9-signaling-to-differentially-polarize-systemic-immune-responses
#11
Jardin A Leleux, Pallab Pradhan, Krishnendu Roy
It is currently unknown whether and how mammalian pathogen recognition receptors (PRRs) respond to biophysical patterns of pathogen-associated molecular danger signals. Using synthetic pathogen-like particles (PLPs) that mimic physical properties of bacteria or large viruses, we have discovered that the quality and quantity of Toll-like receptor 9 (TLR9) signaling by CpG in mouse dendritic cells (mDCs) are uniquely dependent on biophysical attributes; specifically, the surface density of CpG and size of the presenting PLP...
January 17, 2017: Cell Reports
https://www.readbyqxmd.com/read/28087881/role-of-stim2-in-cell-function-and-physiopathology
#12
Alejandro Berna-Erro, Isaac Jardin, Gines M Salido, Juan A Rosado
An endoplasmic reticulum (ER)-resident protein that regulates cytosolic and ER free-Ca(2+) concentration by induction of store-operated calcium entry: that is the original definition of STIM2 and its function. While its activity strongly depends on the amount of calcium stored in the ER, its function goes further, to intracellular signalling and gene expression. Initially under-studied owing to the prominent function of STIM1, STIM2 came to be regarded as vital in mice, gradually emerging as an important player in the nervous system, and cooperating with STIM1 in the immune system...
January 14, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28072043/compelled-to-risk-does-sexual-compulsivity-explain-the-connection-between-borderline-personality-disorder-features-and-number-of-sexual-partners
#13
Charles Jardin, Carla Sharp, Lorra Garey, Salome Vanwoerden, Nic Crist, Jon D Elhai, Michael J Zvolensky
Having more sexual partners increases the likelihood of new HIV infections among women. Women with more borderline personality disorder (BPD) features have been known to have greater numbers of sexual partners. However, the mechanisms linking BPD features with more sexual partners remain to be clarified. Sexual compulsivity (lack of control, increased distress over sexual behavior) may be one such explanatory factor, as it overlaps with BPD features (e.g., impulsivity, negative affectivity). The present study examined whether sexual compulsivity explained the relation of BPD features with number of sexual partners among a diverse sample of college females (N = 1,326)...
January 10, 2017: Journal of Personality Disorders
https://www.readbyqxmd.com/read/28062395/biallelic-mutations-in-dnajc21-cause-shwachman-diamond-syndrome
#14
Santhosh Dhanraj, Anna Matveev, Hongbing Li, Supanun Lauhasurayotin, Lawrence Jardine, Michaela Cada, Bozana Zlateska, Chetankumar S Tailor, Joseph Zhou, Roberto Mendoza-Londono, Ajoy Vincent, Peter R Durie, Stephen W Scherer, Johanna M Rommens, Elise Heon, Yigal Dror
No abstract text is available yet for this article.
January 6, 2017: Blood
https://www.readbyqxmd.com/read/28060738/the-prognostic-value-of-clonal-heterogeneity-and-quantitative-assessment-of-plasma-circulating-clonal-ig-vdj-sequences-at-diagnosis-in-patients-with-follicular-lymphoma
#15
Clémentine Sarkozy, Sarah Huet, Victoria E H Carlton, Bettina Fabiani, Alain Delmer, Fabrice Jardin, Marie-Helene Delfau-Larue, Maya Hacini, Vincent Ribrag, Stéphanie Guidez, Malek Faham, Gilles Salles
Recent advances in next-generation sequencing (NGS) have enabled the quantitation of circulating tumour DNA (ctDNA) encoding the clonal rearranged V(D)J immunoglobulin locus. We aimed to evaluate the clonal heterogeneity of follicular lymphoma (FL) in the tumour and the plasma at diagnosis and to assess the prognostic value of the ctDNA level. Plasma samples at diagnosis were available for 34 patients registered in the PRIMA trial (NCT00140582). One tumour clonotype or more could be detected for 29 (85%) and 25 (74%) patients, respectively, in the tumour or plasma samples...
January 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/28041583/combination-of-ofatumumab-and-reduced-dose-chop-for-diffuse-large-b-cell-lymphomas-in-patients-aged-80-years-or-older-an-open-label-multicentre-single-arm-phase-2-trial-from-the-lysa-group
#16
Frédéric Peyrade, Serge Bologna, Vincent Delwail, Jean François Emile, Laurent Pascal, Christophe Fermé, Jean-Marc Schiano, Bertrand Coiffier, Bernadette Corront, Hassan Farhat, Christophe Fruchart, Herve Ghesquieres, Margaret Macro, Hervé Tilly, Bachra Choufi, Richard Delarue, Olivier Fitoussi, Jean Gabarre, Corinne Haioun, Fabrice Jardin
BACKGROUND: In 2011 we reported a rituximab plus miniCHOP (reduced-dose cyclophosphamide, doxorubicin, vincristine, and prednisone) combination for patients older than 80 years with diffuse large B-cell lymphoma (DLBCL). The 2-year overall survival was 59% (95% CI 49-67) with an excess of early toxicity. To improve those results we tested the same chemotherapy protocol in combination with ofatumumab and a pre-phase treatment. METHODS: For this open-label, multicentre, single-group, phase 2 trial, we recruited patients older than 80 years with untreated histologically-proven CD20-positive DLBCL, Ann Arbor stage I to IV, from 41 academic and hospital centres in France and Belgium...
January 2017: Lancet Haematology
https://www.readbyqxmd.com/read/27986653/can-reduced-intensity-conditioning-regimen-cure-blastic-plasmacytoid-dendritic-cell-neoplasm
#17
Mathieu Leclerc, Régis Peffault de Latour, Mauricette Michallet, Didier Blaise, Patrice Chevallier, Pierre-Simon Rohrlich, Pascal Turlure, Stéphanie Nguyen, Fabrice Jardin, Ibrahim Yakoub-Agha, Sébastien Maury
No abstract text is available yet for this article.
December 16, 2016: Blood
https://www.readbyqxmd.com/read/27976735/pollen-and-spores-as-biological-recorders-of-past-ultraviolet-irradiance
#18
Phillip E Jardine, Wesley T Fraser, Barry H Lomax, Mark A Sephton, Timothy M Shanahan, Charlotte S Miller, William D Gosling
Solar ultraviolet (UV) irradiance is a key driver of climatic and biotic change. Ultraviolet irradiance modulates stratospheric warming and ozone production, and influences the biosphere from ecosystem-level processes through to the largest scale patterns of diversification and extinction. Yet our understanding of ultraviolet irradiance is limited because no method has been validated to reconstruct its flux over timescales relevant to climatic or biotic processes. Here, we show that a recently developed proxy for ultraviolet irradiance based on spore and pollen chemistry can be used over long (10(5) years) timescales...
December 15, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27976468/molecular-fingerprint-comparison-of-closely-related-rose-varieties-based-on-uhplc-hrms-analysis-and-chemometrics
#19
Ludivine Riffault-Valois, Lucille Blanchot, Cyril Colas, Emilie Destandau, Laure Pasquier, Patrice André, Claire Elfakir
INTRODUCTION: The "Jardin de Granville" modern rose variety not only combines the morphological properties of its two parental cultivars, but also possesses better agronomic characteristics (abundant blooms, strong growth and vitality, high resistance to common rose diseases). In addition, it shows remarkable biological properties such as a high ability to decrease inflammatory and oxidative stress on skin cells. That is why Parfums Christian Dior selected this rose variety to be an active ingredient in luxury cosmetics...
January 2017: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/27943309/monoterpene-thermometer-of-tropical-forest-atmosphere-response-to-climate-warming
#20
Kolby J Jardine, Angela B Jardine, Jennifer A Holm, Danica L Lombardozzi, Robinson I Negron-Juarez, Scot T Martin, Harry R Beller, Bruno O Gimenez, Niro Higuchi, Jeffrey Q Chambers
Tropical forests absorb large amounts of atmospheric CO2 through photosynthesis but elevated temperatures suppress this absorption and promote monoterpene emissions. Using (13) CO2 labeling, here we show that monoterpene emissions from tropical leaves derive from recent photosynthesis and demonstrate distinct temperature optima for five groups (Groups 1-5), potentially corresponding to different enzymatic temperature-dependent reaction mechanisms within β-ocimene synthases. As diurnal and seasonal leaf temperatures increased during the Amazonian 2015 El Niño event, leaf and landscape monoterpene emissions showed strong linear enrichments of β-ocimenes (+4...
December 11, 2016: Plant, Cell & Environment
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