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James Cooper

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https://www.readbyqxmd.com/read/28925597/lower-tacrolimus-exposure-and-time-in-therapeutic-range-increase-the-risk-of-de-novo-donor-specific-antibodies-in-the-first-year-of-kidney-transplantation
#1
Scott Davis, Jane Gralla, Patrick Klem, Suhong Tong, Gina Wedermyer, Brian Freed, Alexander Wiseman, James E Cooper
De novo donor-specific antibodies (dnDSA) have been associated with reduced graft survival. Tacrolimus (TAC)-based regimens are the most common immunosuppression used in in clinical practice today, yet an optimal therapeutic dose to prevent dnDSA has not been established. We evaluated mean TAC C0 and TAC time in therapeutic range for the risk of dnDSA in a cohort of 538 patients in the first year of kidney transplant. A mean TAC C0 < 8 ng/ml was associated with dnDSA by 6 months (OR 2.51, 95% CI 1.32-4.79, p=0...
September 19, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28923345/sirt1-is-a-transcriptional-enhancer-of-the-glucocorticoid-receptor-acting-independently-to-its-deacetylase-activity
#2
Shigeru Suzuki, James R Iben, Steven L Coon, Tomoshige Kino
Glucocorticoids have strong effects on diverse human activities through the glucocorticoid receptor (GR). Sirtuin 1 (SIRT1) is a NAD(+)-dependent histone deacetylase and promotes longevity by influencing intermediary metabolism and other regulatory activities including mitochondrial function. In this study, we examined the effects of SIRT1 on GR-mediated transcriptional activity. We found that SIRT1 enhanced GR-induced transcriptional activity on exogenous and endogenous glucocorticoid-responsive genes, whereas knockdown of SIRT1 attenuated it...
September 15, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28921958/electronic-structural-analysis-of-copper-ii-tempo-abno-complexes-provides-evidence-for-copper-i-oxoammonium-character
#3
Richard C Walroth, Kelsey C Miles, James T Lukens, Samantha N MacMillan, Shannon S Stahl, Kyle M Lancaster
Copper/aminoxyl species are proposed as key intermediates in aerobic alcohol oxidation. Several possible electronic structural descriptions of these species are possible, and the present study probes this issue by examining four crystallographically characterized Cu/aminoxyl halide complexes by Cu K-edge, Cu L2,3-edge, and Cl K-edge X-ray absorption spectroscopy. The mixing coefficients between Cu, aminoxyl, and halide orbitals are determined via these techniques with support from density functional theory...
September 18, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28911177/deoxycorticosterone-salt-mediated-cardiac-inflammation-and-fibrosis-are-dependent-on-functional-clock-signaling-in-male-mice
#4
Elizabeth K Fletcher, James Morgan, David R Kennaway, Laura A Bienvenu, Amanda J Rickard, Lea M D Delbridge, Peter J Fuller, Colin D Clyne, Morag J Young
Activation of the mineralocorticoid receptor (MR) promotes inflammation, fibrosis, and hypertension. Clinical and experimental studies show that MR antagonists have significant therapeutic benefit for all-cause heart failure; however, blockade of renal MRs limits their widespread use. Identification of key downstream signaling mechanisms for the MR in the cardiovascular system may enable development of targeted MR antagonists with selectivity for pathological MR signaling and lower impact on physiological renal electrolyte handling...
September 1, 2017: Endocrinology
https://www.readbyqxmd.com/read/28904128/integration-of-kinase-and-calcium-signaling-at-the-level-of-chromatin-underlies-inducible-gene-activation-in-t-cells
#5
Ruth Brignall, Pierre Cauchy, Sarah L Bevington, Bethany Gorman, Angela O Pisco, James Bagnall, Christopher Boddington, William Rowe, Hazel England, Kevin Rich, Lorraine Schmidt, Nigel P Dyer, Mark A Travis, Sascha Ott, Dean A Jackson, Peter N Cockerill, Pawel Paszek
TCR signaling pathways cooperate to activate the inducible transcription factors NF-κB, NFAT, and AP-1. In this study, using the calcium ionophore ionomycin and/or PMA on Jurkat T cells, we show that the gene expression program associated with activation of TCR signaling is closely related to specific chromatin landscapes. We find that calcium and kinase signaling cooperate to induce chromatin remodeling at ∼2100 chromatin regions, which demonstrate enriched binding motifs for inducible factors and correlate with target gene expression...
September 13, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28902361/cooperative-oncogenic-effect-and-cell-signaling-crosstalk-of-co%C3%A2-occurring-her2-and-mutant-pik3ca-in-mammary-epithelial-cells
#6
Lun Dong, Fanyan Meng, Ling Wu, Allison V Mitchell, C James Block, Bin Zhang, Douglas B Craig, Hyejeong Jang, Wei Chen, Qifeng Yang, Guojun Wu
Though incidence of PI3K oncogenic mutation is prominent in breast cancer (20-30%), pharmacological targeting of this signaling pathway alone has failed to provide meaningful clinical benefit. To better understand and address this problem, we conducted genome-wide analysis to study the association of mutant PI3K with other gene amplification events. One of the most significant copy number gain events associated with PIK3CA mutation was the region within chromosome 17 containing HER2. To investigate the oncogenic effect and cell signaling regulation of co-occurring PIK3CA-H1047R and or HER2 gene, we generated cell models ectopically expressing mutant PIK3CA, HER2 or both genetic alterations...
August 30, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28893781/identification-of-heparin-modifications-and-polysaccharide-inhibitors-of-plasmodium-falciparum-merozoite-invasion-that-have-potential-for-novel-drug-development
#7
Michelle J Boyle, Mark Skidmore, Benjamin Dickerman, Lynsay Cooper, Antony Devlin, Edwin Yates, Paul Horrocks, Craig Freeman, Wengang Chai, James G Beeson
Despite recent successful control efforts, malaria remains a leading global health burden. Alarmingly, resistance to current antimalarials is increasing, and the development of new drug families is needed to maintain malaria control. Current antimalarials target the intra-erythrocytic developmental stage of the Plasmodium falciparum life cycle. However, the invasive extracellular parasite form, the merozoite, is also an attractive target for drug development. We have previously demonstrated that heparin-like-molecules, including those with low molecular weights and low anti-coagulant activities are potent and specific inhibitors of merozoite invasion and blood-stage replication...
September 11, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28893742/living-with-crohn-s-disease-an-exploratory-cross-sectional-qualitative-study-into-decision-making-and-expectations-in-relation-to-autologous-haematopoietic-stem-cell-treatment-the-decides-study
#8
Joanne Cooper, Iszara Blake, James O Lindsay, Christopher J Hawkey
BACKGROUND/OBJECTIVES: Severe Crohn's disease impacts negatively on individual quality of life, with treatment options limited once conventional therapies have been exhausted. The aim of this study was to explore factors influencing decision-making and expectations of people considering or participating in the Autologous Haematopoietic Stem Cell Treatment trial. METHODS: An international, cross-sectional qualitative study, involving semistructured face to face interviews across five sites (four UK and one Spain)...
September 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28888237/street-floods-in-metro-manila-and-possible-solutions
#9
Alfredo Mahar Lagmay, Jerico Mendoza, Fatima Cipriano, Patricia Anne Delmendo, Micah Nieves Lacsamana, Marc Anthony Moises, Nicanor Pellejera, Kenneth Niño Punay, Glenn Sabio, Laurize Santos, Jonathan Serrano, Herbert James Taniza, Neil Eneri Tingin
Urban floods from thunderstorms cause severe problems in Metro Manila due to road traffic. Using Light Detection and Ranging (LiDAR)-derived topography, flood simulations and anecdotal reports, the root of surface flood problems in Metro Manila is identified. Majority of flood-prone areas are along the intersection of creeks and streets located in topographic lows. When creeks overflow or when rapidly accumulated street flood does not drain fast enough to the nearest stream channel, the intersecting road also gets flooded...
September 2017: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/28879663/road-side-drug-testing-an-evaluation-of-the-alere-dds%C3%A2-2-mobile-test-system
#10
Timothy P Rohrig, Christine M Moore, Kimberly Stephens, Kelsey Cooper, Cynthia Coulter, Tyson Baird, Margaux Garnier, Samuel Miller, James Tuyay, Kei Osawa, Joshua Chou, Carson Nuss, Jeff Collier, Karen Cudlin Wittman
The number of drivers using drugs has increased over the last few years, and is likely to continue its upward trend. Testing drivers for alcohol use is routine and standardized, but the same is not true for the identification of driving under the influence of drugs (DUID). The Drug Evaluation and Classification Program (DECP) was developed to train police officers to recognize the signs and symptoms of recent drug use and remains an invaluable program; however there are insufficient numbers of these highly trained drug recognition experts (DRE's) who are available to attend every potential drug involved traffic incident...
September 6, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28879363/bio-based-materials-general-discussion
#11
George Huber, Dimitris Argyropoulos, Avtar Matharu, Harry Bitter, Christian Stevens, Servann Herou, Karen Wilson, James Clark, Deepak Pant, Carlos I Cabrera-Rodríguez, Joseph Samec, Bruce E Dale, Thomas Farmer, Mark Mascal, Anne Horan, Andrzej Stankiewicz, Florence Gschwend, Xindong Mu, Long Zhou, Xiaoming Huang, Changwei Hu, Terence Cooper, Laura Sparlinek, Vitaliy Budarin, Eero Kontturi, Andrew Hunt, Amalio Garrido, Keith Waldron, Fang Zhang, Anna Zhenova, David Constable, Simo Sarkanen, Magdalena Titirici, Gadi Rothenberg, Jakob Albert, Duncan Macquarrie
No abstract text is available yet for this article.
September 7, 2017: Faraday Discussions
https://www.readbyqxmd.com/read/28862979/negative-pressure-wound-therapy-for-a-giant-wound-secondary-to-malignancy-induced-necrotizing-fasciitis-case-report-and-review-of-the-literature
#12
Jiayi Hu, Serge Goekjian, Nicolas Stone, Alexandra Nelson, Michael James Cooper
BACKGROUND: Necrotizing fasciitis (NF) is a life-threatening condition in which rapid diagnosis, debridement of nonviable tissue, and broad-spectrum antibiotics are critical to effective treatment. The debridement required can be extensive, resulting in large wounds that can sometimes be covered with split-thickness skin grafts (STSGs) with the help of negative pressure wound therapy (NPWT), or vacuum-assisted closure, to decrease the wound size. CASE REPORT: The authors report a rare case of NF due to malignancy-associated bowel perforation with a giant lower extremity wound secondary to debridement that involved 20% of the total body surface area (TBSA) in a 64-year-old, previously healthy, nonsmoking man...
August 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28859926/impact-of-accurate-30-day-status-on-operative-mortality-wanted-dead-or-alive-not-unknown
#13
W Steves Ring, James R Edgerton, Morley Herbert, Syma Prince, Cathy Knoff, Kristin M Jenkins, Michael E Jessen, Baron L Hamman
BACKGROUND: Risk-adjusted operative mortality is the most important quality metric in cardiac surgery for determining The Society of Thoracic Surgeons (STS) Composite Score for star ratings. Accurate 30-day status is required to determine STS operative mortality. The goal of this study was to determine the effect of unknown or missing 30-day status on risk-adjusted operative mortality in a regional STS Adult Cardiac Surgery Database cooperative and demonstrate the ability to correct these deficiencies by matching with an administrative database...
August 28, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28855217/decreased-severity-of-shiga-toxin-producing-escherichia-coli-haemolytic-uraemic-syndrome-stec-hus-in-a-child-with-type-1-von-willebrand-disease
#14
Matthew A Geramita, Johannes Hofer, James Cooper, Michael L Moritz
Shiga toxin-producing Escherichia coli-associated haemolytic uraemic syndrome (STEC-HUS) is characterised by haemolytic anaemia, thrombocytopenia and acute kidney injury. Von Willebrand Factor (vWF) is an important mediator of normal thrombi formation and indirect evidence suggests that vWF may play an important role in Shiga toxin-induced thrombi formation. Clinical evidence supporting the role of vWF in STEC-HUS is lacking. A 10-year-old girl with type 1 von Willebrand Disease (vWD) had a mild case of STEC-HUS, with nadir haemoglobin 7...
August 30, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28855174/the-euromyositis-registry-an-international-collaborative-tool-to-facilitate-myositis-research
#15
James B Lilleker, Jiri Vencovsky, Guochun Wang, Lucy R Wedderburn, Louise Pyndt Diederichsen, Jens Schmidt, Paula Oakley, Olivier Benveniste, Maria Giovanna Danieli, Katalin Danko, Nguyen Thi Phuong Thuy, Monica Vazquez-Del Mercado, Helena Andersson, Boel De Paepe, Jan L deBleecker, Britta Maurer, Liza J McCann, Nicolo Pipitone, Neil McHugh, Zoe E Betteridge, Paul New, Robert G Cooper, William E Ollier, Janine A Lamb, Niels Steen Krogh, Ingrid E Lundberg, Hector Chinoy
AIMS: The EuroMyositis Registry facilitates collaboration across the idiopathic inflammatory myopathy (IIM) research community. This inaugural report examines pooled Registry data. METHODS: Cross-sectional analysis of IIM cases from 11 countries was performed. Associations between clinical subtypes, extramuscular involvement, environmental exposures and medications were investigated. RESULTS: Of 3067 IIM cases, 69% were female. The most common IIM subtype was dermatomyositis (DM) (31%)...
August 30, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28853538/poly-high-internal-phase-emulsion-for-the-immobilization-of-chemical-warfare-agents
#16
Alexander J Wright, Marcus J Main, Nicholas J Cooper, Barry A Blight, Simon J Holder
We report a facile method for the absorption (characterized by the weight/weight swelling degree, Q) of a variety of chemical warfare agents (CWAs); including sulfur mustard (HD) (Q = 40) and V-series (VM, VX, i-Bu-VX, n-Bu-VX) of nerve agents (Q ≥ 45) and a simulant, methyl benzoate (Q = 55), through the use of a poly(styrene-co-vinyl benzyl chloride-co-divinylbenzene) lightly cross-linked poly high internal phase emulsion (polyHIPE). By varying the vinyl benzyl chloride (VBC) content and the volume of the internal phase of the precursor emulsion it is demonstrated that absorption is facilitated both by the swelling of the polymer and the uptake of liquid in the pores...
September 5, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28842670/the-cellular-and-molecular-determinants-of-emphysematous-destruction-in-copd
#17
Masaru Suzuki, Marc A Sze, Joshua D Campbell, John F Brothers, Marc E Lenburg, John E McDonough, W Mark Elliott, Joel D Cooper, Avrum Spira, James C Hogg
The introduction of microCT has made it possible to show that the terminal bronchioles are narrowed and destroyed before the onset of emphysematous destruction in COPD. This report extends those observations to the cellular and molecular level in the centrilobular phenotype of emphysematous destruction in lungs donated by persons with very severe COPD (n = 4) treated by lung transplantation with unused donor lungs (n = 4) serving as controls. These lung specimens provided companion samples to those previously examined by microCT (n = 61) that we examined using quantitative histology (n = 61) and gene expression profiling (n = 48)...
August 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28841017/hydrogeological-controls-on-regional-scale-indirect-nitrous-oxide-emission-factors-for-rivers
#18
Richard J Cooper, Sarah K Wexler, Christopher A Adams, Kevin M Hiscock
Indirect nitrous oxide (N2O) emissions from rivers are currently derived using poorly constrained default IPCC emission factors (EF5r) which yield unreliable flux estimates. Here, we demonstrate how hydrogeological conditions can be used to develop more refined regional-scale EF5r estimates required for compiling accurate national greenhouse gas inventories. Focusing on three UK river catchments with contrasting bedrock and superficial geologies, N2O and nitrate (NO3(-)) concentrations were analyzed in 651 river water samples collected from 2011 to 2013...
September 7, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28839868/evolving-strategies-to-reduce-colectomy-rates-in-primary-sclerosing-cholangitis-inflammatory-bowel-disease-clinical-remission-of-corticosteroid-refractory-colitis-post-liver-transplant-with-vedolizumab
#19
Saqib Mumtaz, Jason Goh, Gideon M Hirschfield, James Ferguson, Sheldon C Cooper
Primary sclerosing cholangitis (PSC) is associated with inflammatory bowel disease (IBD) in approximately 70% of patients, with ulcerative colitis (UC) being the most common subtype of IBD identified. There is a paucity of data on the optimum management strategy for IBD flares in the post-liver transplant patient, particularly when refractory to conventional treatments. Vedolizumab is a novel gut-specific monoclonal antibody, which has recently been approved for use by National Institute for Health and Care Excellence for moderate-to-severe UC...
October 2016: Frontline Gastroenterology
https://www.readbyqxmd.com/read/28832976/a-phase-1-1b-trial-of-adi-peg-20-plus-nab-paclitaxel-and-gemcitabine-in-patients-with-advanced-pancreatic-adenocarcinoma
#20
Maeve A Lowery, Kenneth H Yu, David Paul Kelsen, James J Harding, John S Bomalaski, Danielle C Glassman, Christina M Covington, Robin Brenner, Ellen Hollywood, Adalberto Barba, Amanda Johnston, Kay Chia-Wei Liu, Xiaoxing Feng, Marinela Capanu, Ghassan K Abou-Alfa, Eileen M O'Reilly
BACKGROUND: ADI-PEG 20 is a pegylated form of the arginine-depleting enzyme arginine deiminase. Normal cells synthesize arginine with the enzyme argininosuccinate synthetase (ASS1); ADI-PEG 20 selectively targets malignant cells, which lack ASS1. METHODS: A single-arm, nonrandomized, open-label, phase 1/1B, standard 3 + 3 dose escalation with an expansion cohort of 9 patients at the recommended phase 2 dose (RP2D) was conducted. Patients who had metastatic pancreatic cancer, up to 1 line of prior treatment (the dose-escalation cohort) or no prior treatment (the expansion cohort), and an Eastern Cooperative Oncology Group performance status of 0 to 1 were included...
August 18, 2017: Cancer
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