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James Cooper

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https://www.readbyqxmd.com/read/29773774/us-and-cuban-scientists-forge-collaboration-on-arbovirus-research
#1
Jorge Pérez-Ávila, Maria G Guzmán-Tirado, Jorge Fraga-Nodarse, Gray Handley, James Meegan, Jose L Pelegrino-Martínez de la Cotera, Anthony S Fauci
After December 17, 2014, when the US and Cuban governments announced their intent to restore relations, the two countries participated in various exchange activities in an effort to encourage cooperation in public health, health research and biomedical sciences. The conference entitled Exploring Opportunities for Arbovirus Research Collaboration, hosted at Havana's Hotel Nacional, was part of these efforts and was the first major US-Cuban scientific conference in over 50 years. Its purpose was to share information about current arbovirus research and recent findings, and to explore opportunities for future joint research...
April 2018: MEDICC Review
https://www.readbyqxmd.com/read/29767012/corrigendum-to-the-role-of-costimulation-blockade-in-solid-organ-and-islet-xenotransplantation
#2
Kannan P Samy, James R Butler, Ping Li, David K C Cooper, Burcin Ekser
[This corrects the article DOI: 10.1155/2017/8415205.].
2018: Journal of Immunology Research
https://www.readbyqxmd.com/read/29766991/response-commentary-analysis-of-sumo1-conjugation-at-synapses
#3
COMMENT
James A Daniel, Benjamin H Cooper, Jorma J Palvimo, Fu-Ping Zhang, Nils Brose, Marilyn Tirard
No abstract text is available yet for this article.
2018: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29766337/a-phase-i-trial-to-determine-safety-and-pharmacokinetics-of-aslan002-an-oral-met-superfamily-kinase-inhibitor-in-patients-with-advanced-or-metastatic-solid-cancers
#4
Aflah Roohullah, Adam Cooper, Anna J Lomax, Jennifer Aung, Alan Barge, Lilian Chow, Mark McHale, Jayesh Desai, James R Whittle, Ben Tran, Paul de Souza, Lisa G Horvath
Background The MET tyrosine kinase and its ligand, hepatocyte growth factor (HGF) also known as scatter factor, are associated with tumourigenesis and metastasis by promotion of scattering, proliferation, angiogenesis, motility and invasion. ASLAN-002 is a potent inhibitor of MET as well as related kinases. A phase I dose escalation study was conducted to determine the safety and pharmacokinetics of ASLAN-002 in patients with advanced cancer. Methods Patients with advanced or metastatic solid tumours, who had progressed on standard therapy or for whom standard therapy was not known, were administered ASLAN-002 orally...
May 16, 2018: Investigational New Drugs
https://www.readbyqxmd.com/read/29765693/homophily-heterophily-and-the-diversity-of-messages-among-decision-making-individuals
#5
Pouria Ramazi, James Riehl, Ming Cao
To better understand the intriguing mechanisms behind cooperation among decision-making individuals, we study the simple yet appealing use of preplay communication or cheap talk in evolutionary games, when players are able to choose strategies based on whether an opponent sends the same message as they do. So when playing games, in addition to pure cooperation and defection, players have two new strategies in this setting: homophilic (respectively, heterophilic) cooperation which is to cooperate (respectively, defect) only with those who send the same message as they do...
April 2018: Royal Society Open Science
https://www.readbyqxmd.com/read/29760414/fragment-derived-inhibitors-of-human-n-myristoyltransferase-block-capsid-assembly-and-replication-of-the-common-cold-virus
#6
Aurélie Mousnier, Andrew S Bell, Dawid P Swieboda, Julia Morales-Sanfrutos, Inmaculada Pérez-Dorado, James A Brannigan, Joseph Newman, Markus Ritzefeld, Jennie A Hutton, Anabel Guedán, Amin S Asfor, Sean W Robinson, Iva Hopkins-Navratilova, Anthony J Wilkinson, Sebastian L Johnston, Robin J Leatherbarrow, Tobias J Tuthill, Roberto Solari, Edward W Tate
Rhinoviruses (RVs) are the pathogens most often responsible for the common cold, and are a frequent cause of exacerbations in asthma, chronic obstructive pulmonary disease and cystic fibrosis. Here we report the discovery of IMP-1088, a picomolar dual inhibitor of the human N-myristoyltransferases NMT1 and NMT2, and use it to demonstrate that pharmacological inhibition of host-cell N-myristoylation rapidly and completely prevents rhinoviral replication without inducing cytotoxicity. The identification of cooperative binding between weak-binding fragments led to rapid inhibitor optimization through fragment reconstruction, structure-guided fragment linking and conformational control over linker geometry...
May 14, 2018: Nature Chemistry
https://www.readbyqxmd.com/read/29760070/pacing-of-paleozoic-macroevolutionary-rates-by-milankovitch-grand-cycles
#7
James S Crampton, Stephen R Meyers, Roger A Cooper, Peter M Sadler, Michael Foote, David Harte
Periodic fluctuations in past biodiversity, speciation, and extinction have been proposed, with extremely long periods ranging from 26 to 62 million years, although forcing mechanisms remain speculative. In contrast, well-understood periodic Milankovitch climate forcing represents a viable driver for macroevolutionary fluctuations, although little evidence for such fluctuation exists except during the Late Cenozoic. The reality, magnitude, and drivers of periodic fluctuations in macroevolutionary rates are of interest given long-standing debate surrounding the relative roles of intrinsic biotic interactions vs...
May 14, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29759114/ribozyme-catalysed-rna-synthesis-using-triplet-building-blocks
#8
James Attwater, Aditya Raguram, Alexey S Morgunov, Edoardo Gianni, Philipp Holliger
RNA-catalyzed RNA replication is widely believed to have supported a primordial biology. However, RNA catalysis is dependent upon RNA folding, and this yields structures that can block replication of such RNAs. To address this apparent paradox we have re-examined the building blocks used for RNA replication. We report RNA-catalysed RNA synthesis on structured templates when using trinucleotide triphosphates (triplets) as substrates, catalysed by a general and accurate triplet polymerase ribozyme that emerged from in vitro evolution as a mutualistic RNA heterodimer...
May 15, 2018: ELife
https://www.readbyqxmd.com/read/29756231/susceptibility-mri-captures-nigral-pathology-in-patients-with-parkinsonian-syndromes
#9
Mechelle M Lewis, Guangwei Du, Jennifer Baccon, Amanda M Snyder, Ben Murie, Felicia Cooper, Christy Stetter, Lan Kong, Christopher Sica, Richard B Mailman, James R Connor, Xuemei Huang
BACKGROUND: Parkinsonisms are neurodegenerative disorders characterized pathologically by α-synuclein-positive (e.g., PD, diffuse Lewy body disease, and MSA) and/or tau-positive (e.g., PSP, cortical basal degeneration) pathology. Using R2* and quantitative susceptibility mapping, susceptibility changes have been reported in the midbrain of living parkinsonian patients, although the exact underlying pathology of these alterations is unknown. OBJECTIVE: The current study investigated the pathological correlates of these susceptibility MRI measures...
May 14, 2018: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29754866/outpatient-pharmacotherapy-for-neonatal-abstinence-syndrome
#10
Faouzi I Maalouf, William O Cooper, James C Slaughter, Judith Dudley, Stephen W Patrick
OBJECTIVE: To determine differences in lengths of stay, length of therapy, emergency department (ED) utilization, and hospital readmissions between infants with neonatal abstinence syndrome (NAS) treated exclusively with inpatient pharmacotherapy compared with those discharged on outpatient pharmacotherapy. STUDY DESIGN: This retrospective cohort study of infants enrolled in the Tennessee Medicaid program used administrative and vital records data from 2009 to 2011...
May 7, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29753032/enhancement-of-cutaneous-wound-healing-by-dsg2-augmentation-of-upar-secretion
#11
Felicia Cooper, Andrew M Overmiller, Anthony Loder, Donna M Brennan-Crispi, Kathleen P McGuinn, Molly R Marous, Theresa A Freeman, Natalia A Riobo-Del Galdo, Linda D Siracusa, James K Wahl, Mỹ G Mahoney
In addition to playing a role in adhesion, desmoglein 2 (Dsg2) is an important regulator of growth and survival signaling pathways, cell proliferation, migration and invasion, and oncogenesis. While low-level Dsg2 expression is observed in basal keratinocytes and is downregulated in non-healing venous ulcers, overexpression has been observed in both melanomas and non-melanoma malignancies. Here, we show that transgenic mice overexpressing Dsg2 in basal keratinocytes primed the activation of mitogenic pathways, but did not induce dramatic epidermal changes or susceptibility to chemical-induced tumor development...
May 9, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29750786/correction-single-trait-and-multi-trait-genome-wide-association-analyses-identify-novel-loci-for-blood-pressure-in-african-ancestry-populations
#12
Jingjing Liang, Thu H Le, Digna R Velez Edwards, Bamidele O Tayo, Kyle J Gaulton, Jennifer A Smith, Yingchang Lu, Richard A Jensen, Guanjie Chen, Lisa R Yanek, Karen Schwander, Salman M Tajuddin, Tamar Sofer, Wonji Kim, James Kayima, Colin A McKenzie, Ervin Fox, Michael A Nalls, J Hunter Young, Yan V Sun, Jacqueline M Lane, Sylvia Cechova, Jie Zhou, Hua Tang, Myriam Fornage, Solomon K Musani, Heming Wang, Juyoung Lee, Adebowale Adeyemo, Albert W Dreisbach, Terrence Forrester, Pei-Lun Chu, Anne Cappola, Michele K Evans, Alanna C Morrison, Lisa W Martin, Kerri L Wiggins, Qin Hui, Wei Zhao, Rebecca D Jackson, Erin B Ware, Jessica D Faul, Alex P Reiner, Michael Bray, Joshua C Denny, Thomas H Mosley, Walter Palmas, Xiuqing Guo, George J Papanicolaou, Alan D Penman, Joseph F Polak, Kenneth Rice, Ken D Taylor, Eric Boerwinkle, Erwin P Bottinger, Kiang Liu, Neil Risch, Steven C Hunt, Charles Kooperberg, Alan B Zonderman, Cathy C Laurie, Diane M Becker, Jianwen Cai, Ruth J F Loos, Bruce M Psaty, David R Weir, Sharon L R Kardia, Donna K Arnett, Sungho Won, Todd L Edwards, Susan Redline, Richard S Cooper, D C Rao, Jerome I Rotter, Charles Rotimi, Daniel Levy, Aravinda Chakravarti, Xiaofeng Zhu, Nora Franceschini
[This corrects the article DOI: 10.1371/journal.pgen.1006728.].
May 2018: PLoS Genetics
https://www.readbyqxmd.com/read/29748051/discovery-of-3-s-thiomethyl-pyrrolidine-erk-inhibitors-for-oncology
#13
Sobhana Babu Boga, Abdul-Basit Alhassan, Alan B Cooper, Ronald Doll, Neng-Yang Shih, Gerald Shipps, Yongqi Deng, Hugh Zhu, Yang Nan, Robert Sun, Liang Zhu, Jagdish Desai, Mehul Patel, Kiran Muppalla, Xiaolei Gao, James Wang, Xin Yao, Joseph Kelly, Subrahmanyam Gudipati, Sunil Paliwal, Hon-Chung Tsui, Tong Wang, Bradley Sherborne, Li Xiao, Alan Hruza, Alexei Buevich, Li-Kang Zhang, David Hesk, Ahmed A Samatar, Donna Carr, Brian Long, Stuart Black, Priya Dayananth, William Windsor, Paul Kirschmeier, Robert Bishop
Compound 5 (SCH772984) was identified as a potent inhibitor of ERK1/2 with excellent selectivity against a panel of kinases (0/231 kinases tested @ 100 nM) and good cell proliferation activity, but suffered from poor PK (rat AUC PK @10 mpk = 0 μM h; F% = 0) which precluded further development. In an effort to identify novel ERK inhibitors with improved PK properties with respect to 5, a systematic exploration of sterics and composition at the 3-position of the pyrrolidine led to the discovery of a novel 3(S)-thiomethyl pyrrolidine analog 28 with vastly improved PK (rat AUC PK @10 mpk = 26 μM h; F% = 70)...
April 26, 2018: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29741711/engagement-with-online-tobacco-marketing-among-adolescents-in-the-us-2013-2014-to-2014-2015
#14
Samir Soneji, JaeWon Yang, Meghan Bridgid Moran, Andy S L Tan, James Sargent, Kristin E Knutzen, Kelvin Choi
Objective: To assess changes in engagement with online tobacco and electronic cigarette marketing ('online tobacco marketing') among adolescents in the US between 2013 and 2015. Methods: We assessed the prevalence of 6 forms of engagement with online tobacco marketing, both overall and by brand, among adolescents sampled in Wave 1 (2013-2014; N=13,651) and Wave 2 (2014-2015; N=12,172) of the nationally representative Population Assessment for Tobacco and Health Study...
May 5, 2018: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/29741382/on-the-border-between-low-nuclearity-and-one-dimensional-solids-a-unique-interplay-of-1-2-4-triazolyl-based-cu-ii-5-oh-2-clusters-and-mo-vi-oxide-matrix
#15
Andrey B Lysenko, Oksana A Bondar, Ganna A Senchyk, Eduard B Rusanov, Monika Srebro-Hooper, James Hooper, Krunoslav Prsa, Karl W Krämer, Silvio Decurtins, Oliver Waldmann, Shi-Xia Liu
A pentanuclear CuII 5 -hydroxo cluster possessing an unusual linear-shaped configuration was formed and crystallized under hydrothermal conditions as a result of the unique cooperation of bridging 1,2,4-triazole ligand ( trans-1,4-cyclohexanediyl-4,4'-bi(1,2,4-triazole) ( tr2 cy)), MoVI -oxide, and CuSO4 . This structural motif can be rationalized by assuming in situ generation of {Cu2 Mo6 O22 }4- anions, which represent heteroleptic derivatives of γ-type [Mo8 O26 ]4- further interlinked by [Cu3 (OH)2 ]4+ cations through [ N- N] bridges...
May 9, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/29735760/disruption-of-a-novel-iron-transport-system-reverses-oxidative-stress-phenotypes-of-a-dpr-mutant-strain-of-streptococcus-mutans
#16
Tridib Ganguly, Jessica K Kajfasz, James H Miller, Eric Rabinowitz, Lívia C C Galvão, Pedro L Rosalen, Jacqueline Abranches, José A Lemos
The Dps-like peroxide resistance protein (Dpr) is essential for H2 O2 stress tolerance and aerobic growth of the oral pathogen Streptococcus mutans Dpr accumulates during oxidative stress, protecting the cell by sequestering iron ions, thereby preventing the generation of toxic hydroxyl radicals that result from the interaction of iron with H2 O2 Previously, we reported that the SpxA1 and SpxA2 regulators positively regulate expression of dpr in S. mutans Using an antibody raised against S. mutans Dpr, we confirmed at the protein level the central and cooperative nature of SpxA1 and SpxA2 regulation in Dpr production...
May 7, 2018: Journal of Bacteriology
https://www.readbyqxmd.com/read/29728977/successful-use-of-advertisement-pictures-to-assist-recall-in-a-food-borne-hepatitis-a-outbreak-in-the-netherlands-2017
#17
Madelief Mollers, Ingeborg L A Boxman, Harry Vennema, Ife A Slegers-Fitz-James, Diederik Brandwagt, Ingrid H Friesema, Jenny S Batstra, Margreet J M Te Wierik
This study describes an outbreak investigation of 14 hepatitis A cases in the Netherlands. The hepatitis A virus (HAV) genotype IB sequences in cases were highly similar (459/460 nt). The origin of strains could be narrowed to Bulgaria based on information from EPIS-FWD. As an association with consumption of soft fruit was suspected, a case-control study was initiated using a questionnaire and a list of pictures of soft fruit available at the supermarket chain involved. Twelve out of 13 cases consumed a specific frozen raspberry/blueberry product shown on the list (OR 46...
May 4, 2018: Food and Environmental Virology
https://www.readbyqxmd.com/read/29728694/outcome-of-children-with-multiply-relapsed-b-cell-acute-lymphoblastic-leukemia-a-therapeutic-advances-in-childhood-leukemia-lymphoma-study
#18
Weili Sun, Jemily Malvar, Richard Sposto, Anupam Verma, Jennifer J Wilkes, Robyn Dennis, Kenneth Heym, Theodore W Laetsch, Melissa Widener, Susan R Rheingold, Javier Oesterheld, Nobuko Hijiya, Maria Luisa Sulis, Van Huynh, Andrew E Place, Henrique Bittencourt, Raymond Hutchinson, Yoav Messinger, Bill Chang, Yousif Matloub, David S Ziegler, Rebecca Gardner, Todd Cooper, Francesco Ceppi, Michelle Hermiston, Luciano Dalla-Pozza, Kirk R Schultz, Paul Gaynon, Alan S Wayne, James A Whitlock
The survival of pediatric patients with multiply relapsed and/or refractory (R/R) B-cell acute lymphoblastic leukemia has historically been very poor; however, data are limited in the current era. We conducted a retrospective study to determine the outcome of multiply R/R childhood B-ALL treated at 24 TACL institutions between 2005 and 2013. Patient information, treatment, and response were collected. Prognostic factors influencing the complete remission (CR) rate and event-free survival (EFS) were analyzed...
March 15, 2018: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/29728387/an-escherichia-coli-nitrogen-starvation-response-is-important-for-mutualistic-coexistence-with-rhodopseudomonas-palustris
#19
Alexandra L McCully, Megan G Behringer, Jennifer R Gliessman, Evgeny V Pilipenko, Jeffrey L Mazny, Michael Lynch, D Allan Drummond, James B McKinlay
Microbial mutualistic cross-feeding interactions are ubiquitous and can drive important community functions. Engaging in cross-feeding undoubtedly affects the physiology and metabolism of individual species involved. However, the nature in which an individual's physiology is influenced by cross-feeding and the importance of those physiological changes for the mutualism have received little attention. We previously developed a genetically tractable coculture to study bacterial mutualisms. The coculture consists of fermentative Escherichia coli and phototrophic Rhodopseudomonas palustris In this coculture, E...
May 4, 2018: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29727228/osteosarcopenia
#20
James Paintin, Cyrus Cooper, Elaine Dennison
Osteosarcopenia is a newly described syndrome that describes the co-existence of osteoporosis and sarcopenia, two chronic musculoskeletal conditions associated with ageing. Osteoporosis, a condition of low bone mass and micro-architectural deterioration of bone, and sarcopenia, the loss of muscle mass, strength and function, often co-exist in a frail subset of the elderly population, leading to significantly worsened outcomes than seen in either condition alone. These include a greater risk of falls, fractures and institutionalization, and significant socioeconomic costs...
May 2, 2018: British Journal of Hospital Medicine
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