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James Cooper

Ross D Blundell, Simon J Williams, Samantha D M Arras, Jessica L Chitty, Kirsten L Blake, Daniel J Ericsson, Nidhi Tibrewal, Jurgen Rohr, Y Q Andre E Koh, Ulrike Kappler, Avril A B Robertson, Mark S Butler, Matthew A Cooper, Bostjan Kobe, James A Fraser
Opportunistic fungal pathogens such as Cryptococcus neoformans are a growing cause of morbidity and mortality among immunocompromised populations worldwide. To address the current paucity of antifungal therapeutic agents, further research into fungal-specific drug targets is required. Adenylosuccinate synthetase (AdSS) is a crucial enzyme in the adeosine triphosphate (ATP) biosynthetic pathway, catalyzing the formation of adenylosuccinate from inosine monophosphate and aspartate. We have investigated the potential of this enzyme as an antifungal drug target, finding that loss of function results in adenine auxotrophy in C...
September 9, 2016: ACS Infectious Diseases
Jamie S Pak, Matthew J Pagano, Kimberly L Cooper, James M McKiernan, Gina M Badalato
OBJECTIVES: To report the prevalence of research misrepresentation among urology residency applicants and assess its effect on match success. METHODS: All applications to the Columbia University urology residency program for the 2014- 2015 match cycle were reviewed. "In-press," "accepted," and "submitted" manuscripts were verified using PubMed, Google Scholar, and journal websites. Misrepresentation for "in-press" and "accepted" manuscripts was defined as: 1) nonexistent manuscript, 2) non-authorship of existent manuscript, 3) self-promotion to a higher author rank, and/or 4) existent manuscript in a non-peer-reviewed publication...
October 14, 2016: Urology
Andrew A Udy, Chelsey Vladic, Edward Robert Saxby, Jeremy Cohen, Anthony Delaney, Oliver Flower, Matthew Anstey, Rinaldo Bellomo, David James Cooper, David V Pilcher
OBJECTIVE: The primary aim of this study was to describe in-hospital mortality in subarachnoid hemorrhage patients requiring ICU admission. Secondary aims were to identify clinical characteristics associated with inferior outcomes, to compare subarachnoid hemorrhage mortality with other neurological diagnoses, and to explore the variability in subarachnoid hemorrhage standardized mortality ratios. DESIGN: Multicenter, binational, retrospective cohort study. SETTING: Data were extracted from the Australian and New Zealand Intensive Care Society Centre for Outcome and Resource Evaluation Adult Patient Database...
October 3, 2016: Critical Care Medicine
Peter James Barron, Katherine Burgess, Kay Cooper, Arthur D Stewart
'Climb assist' claims to reduce strain when climbing ladders; however, no research has yet substantiated this. The purpose of this study was to assess the physiological and psychophysical effects of climb assist on 30 m ladder climbing at a minimum acceptable speed. Eight participants (six male and two female) climbed a 30 m ladder at 24 rungs per minute with and without climb assist, and were monitored for heart rate (HR), [Formula: see text]O2 and rate of perceived exertion (RPE). All three variables decreased significantly (p < 0...
October 15, 2016: Ergonomics
Apoorva Trivedi, Takamura Ashikaga, Daphne Hard, Jessica Archambault, Martin Lachaine, David T Cooper, Harold James Wallace
PURPOSE: Transperineal ultrasound (TPUS) allows for continuous imaging of the prostate gland, but the accuracy of TPUS has not been rigorously studied. We determined the feasibility of prostate imaging with TPUS and subsequently compared prostate localization with TPUS and computed tomography (CT). METHODS AND MATERIALS: We completed 2 sequential evaluations of TPUS. The feasibility study included 15 men with localized prostate cancer and tested if TPUS adequately imaged the prostate...
September 2, 2016: Practical Radiation Oncology
James M Shultz, Janice L Cooper, Florence Baingana, Maria A Oquendo, Zelde Espinel, Benjamin M Althouse, Louis Herns Marcelin, Sherry Towers, Maria Espinola, Clyde B McCoy, Laurie Mazurik, Milton L Wainberg, Yuval Neria, Andreas Rechkemmer
The 2013-2016 West Africa Ebola virus disease pandemic was the largest, longest, deadliest, and most geographically expansive outbreak in the 40-year interval since Ebola was first identified. Fear-related behaviors played an important role in shaping the outbreak. Fear-related behaviors are defined as "individual or collective behaviors and actions initiated in response to fear reactions that are triggered by a perceived threat or actual exposure to a potentially traumatizing event. FRBs modify the future risk of harm...
November 2016: Current Psychiatry Reports
Huabo Wang, Jie Lu, Lia R Edmunds, Sucheta Kulkarni, James Dolezal, Junyan Tao, Sarangarajan Ranganathan, Laura Jackson, Marc Fromherz, Donna Beer Stolz, Radha Uppala, Sivakama Bharathi, Satdarshan P Monga, Eric S Goetzman, Edward V Prochownik
Hepatoblastoma (HB) is associated with aberrant activation of the β-catenin and Hippo/YAP signaling pathways. Over-expression of mutant β-catenin and YAP in mice induces HBs that express high levels of c-Myc (Myc). In light of recent observations that Myc in unnecessary for long-term hepatocyte proliferation, we have now examined its role in HB pathogenesis using the above model. While Myc was found to be dispensable for in vivo HB initiation it was necessary to sustain rapid tumor growth. Gene expression profiling identified key molecular differences between myc+/+ (WT) and myc-/- (KO) hepatocytes and HBs that explain these behaviors...
October 13, 2016: Journal of Biological Chemistry
Michael J Boulton, Louise Boulton, Eleonora Camerone, James Down, Joanna Hughes, Chloe Kirkbride, Rachel Kirkham, Peter Macaulay, Jessica Sanders
Children are heavy users of the Internet and prior studies have shown that many of them lack a good understanding of the risks of doing so and how to avoid them. This study examined if the cross-age teaching zone (CATZ) intervention could help children acquire important knowledge of online risks and safety. It allowed older students to act as CATZ tutors to design and deliver a lesson to younger schoolmates (tutees), using content material about online risks and safety provided by adults. Students in Year 6 (mean age = 11...
October 2016: Cyberpsychology, Behavior and Social Networking
Arlene E Garcia-Soto, James J Java, Wilberto Nieves Neira, J Matthew Pearson, David E Cohn, Shashikant B Lele, Krishnansu S Tewari, Joan L Walker, Angeles Alvarez Secord, Deborah K Armstrong, Larry J Copeland
OBJECTIVES: To determine the relationship of the time from surgery to intraperitoneal (IP) chemotherapy (TSIC) initiation with survival of patients with stage III epithelial ovarian cancer (EOC) patients using ancillary data from cooperative group clinical trials. METHODS: Data from 420 patients with stage III EOC treated with IP chemotherapy under GOG-0114 and 172 were reviewed. The Cox proportional hazards model was used to evaluate independent prognostic factors and estimate their covariate-adjusted effects on PFS and OS...
October 7, 2016: Gynecologic Oncology
Adriano Mesquita Alencar, Mariana Sacrini Ayres Ferraz, Chan Young Park, Emil Millet, Xavier Trepat, Jeffrey J Fredberg, James P Butler
The cytoskeleton (CSK) is a tensed fiber framework that supports, shapes and stabilizes the cell. The CSK is in a constant state of remodeling, moreover, which is an active non-equilibrium thermodynamic process. We report here that cytoskeletal remodeling involves reconfigurations that are not only sudden but also are transmitted to great distances within the cell in a fashion reminiscent of quakes in the Earth's crust. Remarkably, these events in the cell conform both qualitatively and quantitatively to empirical laws typical of earthquakes, including hierarchical fault structures, cumulative energy distributions following the Gutenberg-Richter law, and rate of after-shocks following Omori's law...
September 26, 2016: Soft Matter
José María Parisi, José Luis Castro, María Celina Luque, Marta Spinetto, Patricia Saidón, James Fitzgerald
Objective To describe the benefits obtained through South-South and triangular cooperation as a potential tool for strengthening medicine quality control in official medicines control laboratories (OMCLs) of the Region of the Americas. Methods Descriptive study of the project for strengthening drug quality control in OMCLs of the Caribbean community (CARICOM). Results Staff members of Argentina's National Administration for Drugs, Food, and Medical Technology (ANMAT) provided training to professionals from Guyana, Jamaica, Suriname, and Trinidad and Tobago...
May 2016: Revista Panamericana de Salud Pública, Pan American Journal of Public Health
Charles Preston, Harinder S Chahal, Analia Porrás, Lucette Cargill, Maryam Hinds, Babatunde Olowokure, Rudolph Cummings, James Hospedales
Improving basic capacities for regulation of medicines and health technologies through regulatory systems strengthening is particularly challenging in resource-constrained settings. "Regionalization"-an approach in which countries with common histories, cultural values, languages, and economic conditions work together to establish more efficient systems-may be one answer. This report describes the Caribbean Regulatory System (CRS), a regionalization initiative being implemented in the mostly small countries of the Caribbean Community and Common Market (CARICOM)...
May 2016: Revista Panamericana de Salud Pública, Pan American Journal of Public Health
J L Hudgens, J A Cooper, M L Russo, L Elizabeth, S James, M Daniel
No abstract text is available yet for this article.
November 2015: Journal of Minimally Invasive Gynecology
Andrew Grier, Paul Dean, Alexander Valavanis, James Keeley, Iman Kundu, Jonathan D Cooper, Gary Agnew, Thomas Taimre, Yah Leng Lim, Karl Bertling, Aleksandar D Rakić, Lianhe H Li, Paul Harrison, Edmund H Linfield, Zoran Ikonić, A Giles Davies, Dragan Indjin
We explain the origin of voltage variations due to self-mixing in a terahertz (THz) frequency quantum cascade laser (QCL) using an extended density matrix (DM) approach. Our DM model allows calculation of both the current-voltage (I-V) and optical power characteristics of the QCL under optical feedback by changing the cavity loss, to which the gain of the active region is clamped. The variation of intra-cavity field strength necessary to achieve gain clamping, and the corresponding change in bias required to maintain a constant current density through the heterostructure is then calculated...
September 19, 2016: Optics Express
James B Fields, Karin L Németh-Cahalan, J Alfredo Freites, Irene Vorontsova, James E Hall, Douglas J Tobias
Aquaporin 0 (AQP0), the major intrinsic protein of the eye lens, plays a vital role in maintaining lens clarity by facilitating the transport of water across lens fiber cell membranes. AQP0 reduces its osmotic water permeability constant (Pf) in response to increases in the external calcium concentration, an effect that is mediated by an interaction with the calcium-binding messenger protein, calmodulin (CaM), and phosphorylation of the CaM binding site abolishes calcium sensitivity. Despite recent structural characterization of the AQP0-CaM complex, the mechanism by which CaM modulates AQP0 remains poorly understood...
September 22, 2016: Journal of Biological Chemistry
Santosh L Saraf, Binal N Shah, Xu Zhang, Jin Han, Bamidele O Tayo, Taimur Abbasi, Adam Ostrower, Elizabeth Guzman, Robert E Molokie, Michel Gowhari, Johara Hassan, Shivi Jain, Richard S Cooper, Roberto F Machado, James P Lash, Victor R Gordeuk
No abstract text is available yet for this article.
September 22, 2016: Haematologica
Christian S Müller, Tim Knehans, Dmitri R Davydov, Patricia L Bounds, Ursula von Mandach, James R Halpert, Amedeo Caflisch, Willem H Koppenol
No abstract text is available yet for this article.
October 4, 2016: Biochemistry
Prabhakar Rajiah, Mojgan Hojjati, Ziang Lu, Vijaya Kosaraju, Sasan Partovi, James K O'Donnell, Christopher Longenecker, Grace A McComsey, Jackelyn B Golden, Fuad Muakkassa, Scott Santilli, Thomas S McCormick, Kevin D Cooper, Neil J Korman
We report our initial experience of performing integrated PET/MR imaging of the carotid arteries in psoriatic patients. Eleven patients with psoriasis and ten controls underwent carotid PET/MRI. Following injection of the FDG tracer, 3d T1w gradient echo sequence (atMR) was obtained for attenuation correction of PET data. High resolution images of carotid artery were then obtained, including pre-and post-contrast T1-w, T2-w and proton-density images as well as TOF images followed by PET imaging of the torso...
2016: American Journal of Nuclear Medicine and Molecular Imaging
Margaret H Sibley, James M Swanson, L Eugene Arnold, Lily T Hechtman, Elizabeth B Owens, Annamarie Stehli, Howard Abikoff, Stephen P Hinshaw, Brooke S G Molina, John T Mitchell, Peter S Jensen, Andrea L Howard, Kimberley D Lakes, William E Pelham
OBJECTIVE: Longitudinal studies of children diagnosed with ADHD report widely ranging ADHD persistence rates in adulthood (5-75%). This study documents how information source (parent vs. self-report), method (rating scale vs. interview), and symptom threshold (DSM vs. norm-based) influence reported ADHD persistence rates in adulthood. METHOD: Five hundred seventy-nine children were diagnosed with DSM-IV ADHD-Combined Type at baseline (ages 7.0-9.9 years) 289 classmates served as a local normative comparison group (LNCG), 476 and 241 of whom respectively were evaluated in adulthood (Mean Age = 24...
September 19, 2016: Journal of Child Psychology and Psychiatry, and Allied Disciplines
Scott Horowitz, Brian Koepnick, Raoul Martin, Agnes Tymieniecki, Amanda A Winburn, Seth Cooper, Jeff Flatten, David S Rogawski, Nicole M Koropatkin, Tsinatkeab T Hailu, Neha Jain, Philipp Koldewey, Logan S Ahlstrom, Matthew R Chapman, Andrew P Sikkema, Meredith A Skiba, Finn P Maloney, Felix R M Beinlich, Zoran Popović, David Baker, Firas Khatib, James C A Bardwell
We show here that computer game players can build high-quality crystal structures. Introduction of a new feature into the computer game Foldit allows players to build and real-space refine structures into electron density maps. To assess the usefulness of this feature, we held a crystallographic model-building competition between trained crystallographers, undergraduate students, Foldit players and automatic model-building algorithms. After removal of disordered residues, a team of Foldit players achieved the most accurate structure...
2016: Nature Communications
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