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Zhen Wang

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https://www.readbyqxmd.com/read/29334136/a-bayesian-network-meta-analysis-efficacy-of-air-insufflation-co2-insufflation-water-exchange-and-water-immersion-in-colonoscopy
#1
REVIEW
Zhen Zhang, Yifeng Wu, Guangge Sun, Jing Zhang, Jiaxin Li, Chongyang Qiu, Xin Zheng, Botao Wang, Lei Yang, Ximo Wang
BACKGROUND: Colonoscopy is one of the excellent tools for screening colorectal cancer. There were four colonoscopy techniques containing air insufflation, CO2 insufflation, water exchange, and water immersion. Some studies reported that these methods are better than the criterion standard (air insufflation), while some studies showed not. In order to evaluate the efficacy of four colonoscopy techniques, a network meta-analysis was performed in present study. METHODS: We searched randomized controlled trials (RCTs) published up to September 2017 from PubMed, Embase, Cochrane library, and Web of Science...
January 15, 2018: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/29334122/inhibition-of-hsp90%C3%AE-protects-cultured-neurons-from-oxygen-glucose-deprivation-induced-necroptosis-by-decreasing-rip3-expression
#2
Zhen Wang, Li-Min Guo, Yong Wang, Hong-Kang Zhou, Shu-Chao Wang, Dan Chen, Ju-Fang Huang, Kun Xiong
Heat shock protein 90α (HSP90α) maintains cell stabilization and regulates cell death, respectively. Recent studies have shown that HSP90α is involved in receptor interacting protein 3 (RIP3)-mediated necroptosis in HT29 cells. It is known that oxygen and glucose deprivation (OGD) can induce necroptosis, which is regulated by RIP3 in neurons. However, it is still unclear whether HSP90α participates in the process of OGD-induced necroptosis in cultured neurons via the regulation of RIP3. Our study found that necroptosis occurs in primary cultured cortical neurons and PC-12 cells following exposure to OGD insult...
November 20, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29333587/genetic-characterization-and-modification-of-a-bioethanol-producing-yeast-strain
#3
Ke Zhang, Ya-Nan Di, Lei Qi, Yang Sui, Ting-Yu Wang, Li Fan, Zhen-Mei Lv, Xue-Chang Wu, Pin-Mei Wang, Dao-Qiong Zheng
Yeast Saccharomyces cerevisiae strains isolated from different sources generally show extensive genetic and phenotypic diversity. Understanding how genomic variations influence phenotypes is important for developing strategies with improved economic traits. The diploid S. cerevisiae strain NY1308 is used for cellulosic bioethanol production. Whole genome sequencing identified an extensive amount of single nucleotide variations and small insertions/deletions in the genome of NY1308 compared with the S288c genome...
January 15, 2018: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29332820/a-strategy-for-screening-of-%C3%AE-glucosidase-inhibitors-from-morus-alba-root-bark-based-on-the-ligand-fishing-combined-with-high-performance-liquid-chromatography-mass-spectrometer-and-molecular-docking
#4
Zhen Wang, Xiaoqing Li, Menghan Chen, Feiyan Liu, Chao Han, Lingyi Kong, Jianguang Luo
A new method based on ligand fishing combined with high-performance liquid chromatography quadrupole-time-of-flight mass spectrometer and molecular docking was established to screen α-glucosidase inhibitors from a traditional Chinese medicine Morus alba root bark. α-Glucosidase was immobilized on magnetic nanoparticles, used as a solid support to incubate with crude extract. After ligand fishing, the eluates were analyzed by high-performance liquid chromatography quadrupole-time-of-flight mass spectrometer, obtaining eleven ligands (1-4, 6-12) eventually...
April 1, 2018: Talanta
https://www.readbyqxmd.com/read/29331887/idh1r132h-promotes-malignant-transformation-of-benign-prostatic-epithelium-by-dysregulating-micrornas-involvement-of-igf1r-akt-stat3-signaling-pathway
#5
Lili Zhang, Mei Qi, Tingting Feng, Jing Hu, Lin Wang, Xinjun Li, Wei Gao, Hui Liu, Meng Jiao, Zhen Wu, Xinnuo Bai, Yifan Bie, Long Liu, Bo Han
Risk stratification using molecular features could potentially help distinguish indolent from aggressive prostate cancer (PCa). Mutations in isocitrate dehydrogenase (IDH) acquire an abnormal enzymatic activity, resulting in the production of 2-hydroxyglutarate and alterations in cellular metabolism, histone modification, and DNA methylation. Mutant IDH1 has been identified in various human malignancies, and IDH1R132H constituted the vast majority of mutational events of IDH1. Most recent studies suggested that IDH1 mutations define a methylator subtype in PCa...
January 11, 2018: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/29331704/mindfulness-based-interventions-for-major-depressive-disorder-a-comprehensive-meta-analysis-of-randomized-controlled-trials
#6
Yuan-Yuan Wang, Xiao-Hong Li, Wei Zheng, Zi-Yan Xu, Chee H Ng, Gabor S Ungvari, Zhen Yuan, Yu-Tao Xiang
BACKGROUND: This is a meta-analysis of randomized controlled trials (RCTs) of mindfulness-based interventions (MBIs) for a current episode of major depressive disorder. METHODS: Both English (PubMed, PsycINFO, Embase, and Cochrane Library databases) and Chinese (WanFang and CNKI) databases were systematically and independently searched. Standardized mean differences (SMDs) and risk ratio (RR) ± their 95% confidence intervals (CIs) based on the random effects model were calculated...
January 3, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29331428/heating-enhanced-sensitive-and-selective-electrochemical-detection-of-hg2-based-on-t-hg2-t-structure-and-exonuclease-iii-assisted-target-recycling-amplification-strategy-at-heated-gold-disk-electrode
#7
Shao-Hua Wu, Biao Zhang, Fang-Fang Wang, Zhen-Zhen Mi, Jian-Jun Sun
A sensitive and selective electrochemical Hg2+ sensor was developed based on T-Hg2+-T structure and exonuclease (Exo) III -assisted target recycling amplification at heated gold disk electrode (HAuDE). First, a DNA signal probe P1 was for the first time designed and labeled with ferrocene (Fc) near the attached SH-5'-end, so as to shorten the distance between Fc and the electrode and enhance the initial current of Fc compared with that labeled at the 3'-end far from the electrode. Then the signal amplification was achieved by Exo III-assisted Hg2+ recycling...
January 5, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29331025/multidimensional-endotypes-of-chronic-rhinosinusitis-and-their-association-with-treatment-outcomes
#8
Bo Liao, Jin-Xin Liu, Zhi-Yong Li, Zhen Zhen, Ping-Ping Cao, Yin Yao, Xiao-Bo Long, Heng Wang, Yan Wang, Robert Schleimer, Zheng Liu
BACKGROUND: The expression of chronic rhinosinusitis (CRS) is multidimensional. Disease heterogeneity in patients with CRS remains poorly understood. This study aimed to identify endotypes of CRS using cluster analysis by integrating multidimensional characteristics and to explore their association with treatment outcomes. METHODS: A total of 28 clinical variables and 39 mucosal cellular and molecular variables were analyzed using principal component analysis. Cluster analysis was performed on 246 prospectively recruited Chinese CRS patients with at least one-year post-operative follow-up...
January 13, 2018: Allergy
https://www.readbyqxmd.com/read/29329805/preparative-expression-and-purification-of-a-nacreous-protein-n16-and-testing-its-effect-on-osteoporosis-rat-model
#9
Zhen-Yan Xu, Yu-Ling Liu, Jia-Bi Lin, Ke-Ling Cheng, Yong-Gang Wang, Hong-Liang Yao, Wei-Peng, Hoi-Yan Wu, Wei-Wei Su, Pang-Chui Shaw, Pei-Bo Li
N16, a nacreous protein isolated from Pinctada martensii, is related to nacreous layer formation. Our previous study indicated that N16 showed dual regulatory effects by inducing osteoblast biomineralization as well as inhibiting osteoclast formation. In order to obtain large quantity of N16 for animal experiment and clinical trial, a fermentation and preparative purification method was established. The N16 cDNA was cloned to a BL21(DE3)plysE-pET32a vector and grown in a 20 L fermenter. The medium, temperature, pH and dissolved oxygen (DO) were optimized...
January 9, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29329647/atractylodes-lancea-rhizome-water-extract-reduces-triptolide-induced-toxicity-and-enhances-anti-inflammatory-effects
#10
Yuan Wei, Dan-Juan Sui, Hai-Miao Xu, Zhen Ouyang, Na Wu, Du-Jun Wang, Xiao-Yan Zhang, Da-Wei Qian
The present study was designed to explore the influence of water extracts of Atractylodes lancea rhizomes on the toxicity and anti-inflammatory effects of triptolide (TP). A water extract was prepared from A. lancea rhizomes and co-administered with TP in C57BL/6 mice. The toxicity was assayed by determining serum biochemical parameters and visceral indexes and by liver histopathological analysis. The hepatic CYP3A expression levels were detected using Western blotting and RT-PCR methods. The data showed that the water extract of A...
December 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/29329245/underwater-object-segmentation-based-on-optical-features
#11
Zhe Chen, Zhen Zhang, Yang Bu, Fengzhao Dai, Tanghuai Fan, Huibin Wang
Underwater optical environments are seriously affected by various optical inputs, such as artificial light, sky light, and ambient scattered light. The latter two can block underwater object segmentation tasks, since they inhibit the emergence of objects of interest and distort image information, while artificial light can contribute to segmentation. Artificial light often focuses on the object of interest, and, therefore, we can initially identify the region of target objects if the collimation of artificial light is recognized...
January 12, 2018: Sensors
https://www.readbyqxmd.com/read/29328466/knockdown-of-immature-colon-carcinoma-transcript%C3%A2-1-induces-suppression-of-proliferation-s-phase-arrest-and-apoptosis-in-leukemia-cells
#12
Guang-Yao Li, Ji-Zhu Liu, Li Zhang, Guo-Zhen Liu, Shuang-Jing Li, Tai-Wu Xiao, Jing-Xia Wang, Le-Xin Wang, Ming Hou
Immature colon carcinoma transcript 1 (ICT1), a human mitochondrial translation release factor, is a ribosome-dependent codon-independent peptidyl-tRNA hydrolase. ICT1-deficiency has been recognized as a cell growth inhibitor of hepatoblastoma and glioblastoma multiforme. To explore the role of ICT1 in human leukemia, 2 short hairpin RNAs (shRNAs) targeting ICT1 sequences were designed in leukemia U937 cells. The successful infection of ICT1 in the U937 cells was observed under a fluorescence microscope and further quantified by western blotting and quantitative real-time PCR (qRT-PCR) analysis...
January 3, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29328461/anti%C3%A2-inflammatory-effects-of-gambogic-acid-in-murine-collagen%C3%A2-induced-arthritis-through-pi3k-akt-signaling-pathway
#13
Qing Lai Wang, Dong Zhen Yang, Cunxian Lv
Garcinia angustifolia is a dry resin secreted by Garcinia cambogia, which has the functions of breaking blood, detoxifying, stopping bleeding and killing insects. It is used for the treatment of cancer and brain edema. Gambogic acid is the primary active ingredient. The present study aimed to investigate the anti‑inflammatory and antiproliferative effects of gambogic acid on arthritis and the possible mechanisms. It was demonstrated that gambogic acid decreased arthritic scores in murine collagen‑induced arthritic mice...
January 8, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29328446/clinical-significance-of-iroquois-homeobox-gene-irx1-in-human-glioma
#14
Pengxing Zhang, Nan Liu, Xiaoshan Xu, Zhen Wang, Yingduan Cheng, Weilin Jin, Xin Wang, Hongwei Yang, Hui Liu, Yongsheng Zhang, Yanyang Tu
The present study aimed to investigate the location, expression and clinical significance of Iroquois homeobox gene (IRX1) in human glioma. The expression of IRX1 gene in glioma cell lines (U87, U373, LN229 and T98G) and normal brain tissue was detected via reverse transcription-polymerase chain reaction. The IRX1 protein in fresh glioma specimens, with the adjacent normal brain tissue, was quantified through western blotting. The archived glioma only specimens from the present hospital and glioma specimens with adjacent normal brain tissue, from Alenabio biotechnology, were subjected to immunohistochemistry and tissue microarray analysis, respectively...
January 9, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29328278/controlled-phase-manipulation-module-for-orbital-angular-momentum-photon-states
#15
Fang-Xiang Wang, Juan Wu, Wei Chen, Zhen-Qiang Yin, Shuang Wang, Guang-Can Guo, Zheng-Fu Han
Phase manipulation is essential to quantum information processing, for which the orbital angular momentum (OAM) of photon is a promising high-dimensional resource. Dove prism (DP) is one of the most important elements to realize the nondestructive phase manipulation of OAM photons. DP usually changes the polarization of light and thus increases the manipulation error for a spin-OAM hybrid state. DP in a Sagnac interferometer also introduces a mode-dependent global phase to the OAM mode. In this work, we implemented a high-dimensional controlled-phase manipulation module (PMM), which can compensate the mode-dependent global phase and thus preserve the phase in the spin-OAM hybrid superposition state...
January 15, 2018: Optics Letters
https://www.readbyqxmd.com/read/29328194/subwavelength-wave-manipulation-in-a-thin-surface-wave-bandgap-crystal
#16
Zhen Gao, Zhuoyuan Wang, Baile Zhang
It has been recently reported that the unit cell of wire media metamaterials can be tailored locally to shape the flow of electromagnetic waves at deep-subwavelength scales [Nat. Phys.9, 55 (2013)NPAHAX1745-247310.1038/nphys2480]. However, such bulk structures have a thickness of at least the order of wavelength, thus hindering their applications in the on-chip compact plasmonic integrated circuits. Here, based upon a Sievenpiper "mushroom" array [IEEE Trans. Microwave Theory Tech.47, 2059 (1999)IETMAB0018-948010...
January 1, 2018: Optics Letters
https://www.readbyqxmd.com/read/29327729/h5n1-influenza-virus-specific-mirna-like-small-rna-increases-cytokine-production-and-mouse-mortality-via-targeting-poly-rc-binding-protein-2
#17
Xihan Li, Zheng Fu, Hongwei Liang, Yanbo Wang, Xian Qi, Meng Ding, Xinlei Sun, Zhen Zhou, Ying Huang, Hongwei Gu, Limin Li, Xi Chen, Donghai Li, Quan Zhao, Fenyong Liu, Hua Wang, Jin Wang, Ke Zen, Chen-Yu Zhang
Infection of H5N1 influenza virus causes the highest mortality among all influenza viruses. The mechanisms underlying such high viral pathogenicity are incompletely understood. Here, we report that the H5N1 influenza virus encodes a microRNA-like small RNA, miR-HA-3p, which is processed from a stem loop-containing viral RNA precursor by Argonaute 2, and plays a role in enhancing cytokine production during H5N1 infection. Mechanistic study shows that miR-HA-3p targets poly(rC)-binding protein 2 (PCBP2) and suppresses its expression...
January 12, 2018: Cell Research
https://www.readbyqxmd.com/read/29327726/generation-of-knock-in-cynomolgus-monkey-via-crispr-cas9-editing
#18
Xuan Yao, Zhen Liu, Xing Wang, Yan Wang, Yan-Hong Nie, Liang Lai, Ruilin Sun, Linyu Shi, Qiang Sun, Hui Yang
No abstract text is available yet for this article.
January 12, 2018: Cell Research
https://www.readbyqxmd.com/read/29327595/the-pretransplant-neutrophil-lymphocyte-ratio-as-a-new-prognostic-predictor-after-liver-transplantation-for-hepatocellular-cancer-a-systematic-review-and-meta-analysis
#19
Zheng-Guang Xu, Cheng-Jie Ye, Lin-Xun Liu, Gang Wu, Zhan-Xue Zhao, Yong-Zhen Wang, Bing-Qiang Shi, Yong-Hong Wang
AIM: Recently, many reports showed that the pretransplant neutrophil-lymphocyte ratio (NLR) may be correlated with the prognosis of patients undergoing liver transplantation (LT) for hepatocellular cancer (HCC). However, their results still remained controversial. Thus we performed a meta-analysis of 13 studies to estimate the prognostic value of pretransplant NLR. METHODS: Databases including PubMed, Embase, Cochrane Library and Web of Science were searched to September 2017...
January 12, 2018: Biomarkers in Medicine
https://www.readbyqxmd.com/read/29327395/effects-of-traditional-chinese-medicine-formula-on-ruminal-fermentation-enzyme-activities-and-nutrient-digestibility-of-beef-cattle
#20
Zhi Zhu, Zhen-Hui Song, Li-Ting Cao, Yong Wang, Wen-Zhang Zhou, Pei Zhou, Fu-Yuan Zuo
This study was conducted to evaluate effects of traditional Chinese medicine formula (TCMF) combined with several herbs on ruminal fermentation, enzyme activities and nutrient digestibility. Twenty finishing bulls were assigned to control or different TCMFs (Yufeisan-1, -2, -3; 2.5% dry matter (DM) in concentrate). Results showed that DM intake was higher (P < 0.05) in the Yufeisan-3 group than others. Compared to control, apparent digestibility of crude protein and neutral detergent fiber were increased (P < 0...
January 12, 2018: Animal Science Journal, Nihon Chikusan Gakkaihō
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