keyword
MENU ▼
Read by QxMD icon Read
search

John G. Laffey

keyword
https://www.readbyqxmd.com/read/27864036/comorbidities-and-the-risk-of-mortality-in-patients-with-bronchiectasis-an-international-multicentre-cohort-study
#1
Melissa J McDonnell, Stefano Aliberti, Pieter C Goeminne, Marcos I Restrepo, Simon Finch, Alberto Pesci, Lieven J Dupont, Thomas C Fardon, Robert Wilson, Michael R Loebinger, Dusan Skrbic, Dusanka Obradovic, Anthony De Soyza, Chris Ward, John G Laffey, Robert M Rutherford, James D Chalmers
BACKGROUND: Patients with bronchiectasis often have concurrent comorbidities, but the nature, prevalence, and impact of these comorbidities on disease severity and outcome are poorly understood. We aimed to investigate comorbidities in patients with bronchiectasis and establish their prognostic value on disease severity and mortality rate. METHODS: An international multicentre cohort analysis of outpatients with bronchiectasis from four European centres followed up for 5 years was done for score derivation...
November 15, 2016: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/27862448/a-protocol-for-pressurized-liquid-extraction-and-processing-methods-to-isolate-modern-and-ancient-bone-cholesterol-for-compound-specific-stable-isotope-analysis
#2
Ann O Laffey, John Krigbaum, Andrew R Zimmerman
RATIONALE: Bone lipid compound-specific isotope analysis (CSIA) and bone collagen and apatite stable isotope ratio analysis are important sources of ecological and paleodietary information. Pressurized liquid extraction (PLE) is quicker and utilizes less solvent than traditional methods of lipid extraction such as soxhlet and ultrasonication. This study facilitates dietary analysis by optimizing and testing a standardized methodology for PLE of bone cholesterol. METHODS: Modern and archaeological bone were extracted by PLE using varied temperatures, solvent solutions, and sample weights...
November 8, 2016: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/27861182/cryopreserved-xeno-free-human-umbilical-cord-mesenchymal-stromal-cells-reduce-lung-injury-severity-and-bacterial-burden-in-rodent-escherichia-coli-induced-acute-respiratory-distress-syndrome
#3
Gerard F Curley, Mirjana Jerkic, Steve Dixon, Grace Hogan, Claire Masterson, Daniel O'Toole, James Devaney, John G Laffey
OBJECTIVE: Although mesenchymal stem/stromal cells represent a promising therapeutic strategy for acute respiratory distress syndrome, clinical translation faces challenges, including scarcity of bone marrow donors, and reliance on bovine serum during mesenchymal stem/stromal cell proliferation. We wished to compare mesenchymal stem/stromal cells from human umbilical cord, grown in xeno-free conditions, with mesenchymal stem/stromal cells from human bone marrow, in a rat model of Escherichia coli pneumonia...
November 16, 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27757516/potentially-modifiable-factors-contributing-to-outcome-from-acute-respiratory-distress-syndrome-the-lung-safe-study
#4
John G Laffey, Giacomo Bellani, Tài Pham, Eddy Fan, Fabiana Madotto, Ednan K Bajwa, Laurent Brochard, Kevin Clarkson, Andres Esteban, Luciano Gattinoni, Frank van Haren, Leo M Heunks, Kiyoyasu Kurahashi, Jon Henrik Laake, Anders Larsson, Daniel F McAuley, Lia McNamee, Nicolas Nin, Haibo Qiu, Marco Ranieri, Gordon D Rubenfeld, B Taylor Thompson, Hermann Wrigge, Arthur S Slutsky, Antonio Pesenti
PURPOSE: To improve the outcome of the acute respiratory distress syndrome (ARDS), one needs to identify potentially modifiable factors associated with mortality. METHODS: The large observational study to understand the global impact of severe acute respiratory failure (LUNG SAFE) was an international, multicenter, prospective cohort study of patients with severe respiratory failure, conducted in the winter of 2014 in a convenience sample of 459 ICUs from 50 countries across five continents...
October 18, 2016: Intensive Care Medicine
https://www.readbyqxmd.com/read/27753501/non-invasive-ventilation-of-patients-with-ards-insights-from-the-lung-safe-study
#5
Giacomo Bellani, John G Laffey, Tài Pham, Fabiana Madotto, Eddy Fan, Laurent Brochard, Andres Esteban, Luciano Gattinoni, Vesna Bumbasirevic, Lise Piquilloud, Frank van Haren, Anders Larsson, Daniel F McAuley, Philippe R Bauer, Yaseen M Arabi, Marco Ranieri, Massimo Antonelli, Gordon D Rubenfeld, B Taylor Thompson, Hermann Wrigge, Arthur S Slutsky, Antonio Pesenti
BACKGROUND: Non-invasive ventilation (NIV) is increasingly used in patients with Acute Respiratory Distress Syndrome (ARDS). Whether, during NIV, the categorization of ARDS severity based on the PaO2/FiO2 Berlin criteria is useful is unknown. The evidence supporting NIV use in patients with ARDS remains relatively sparse. METHODS: The Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE (LUNG SAFE) study described the management of patients with ARDS...
October 18, 2016: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/27408702/recent-insights-mesenchymal-stromal-stem-cell-therapy-for-acute-respiratory-distress-syndrome
#6
REVIEW
Shahd Horie, John G Laffey
Acute respiratory distress syndrome (ARDS) causes respiratory failure, which is associated with severe inflammation and lung damage and has a high mortality and for which there is no therapy. Mesenchymal stromal/stem cells (MSCs) are adult multi-progenitor cells that can modulate the immune response and enhance repair of damaged tissue and thus may provide a therapeutic option for ARDS. MSCs demonstrate efficacy in diverse in vivo models of ARDS, decreasing bacterial pneumonia and ischemia-reperfusion-induced injury while enhancing repair following ventilator-induced lung injury...
2016: F1000Research
https://www.readbyqxmd.com/read/27001525/hypercapnic-acidosis-attenuates-pulmonary-epithelial-stretch-induced-injury-via-inhibition-of-the-canonical-nf-%C3%AE%C2%BAb-pathway
#7
Shahd Horie, Bilal Ansari, Claire Masterson, James Devaney, Michael Scully, Daniel O'Toole, John G Laffey
BACKGROUND: Hypercapnia, with its associated acidosis (HCA), is a consequence of respiratory failure and is also seen in critically ill patients managed with conventional "protective" ventilation strategies. Nuclear factor kappa-B (NF-κB), a pivotal transcription factor, is activated in the setting of injury and repair and is central to innate immunity. We have previously established that HCA protects against ventilation-induced lung injury in vivo, potentially via a mechanism involving inhibition of NF-κB signaling...
December 2016: Intensive Care Medicine Experimental
https://www.readbyqxmd.com/read/26980194/the-ten-studies-that-should-be-done-in-ards
#8
Shailesh Bihari, John G Laffey, Andrew D Bersten
No abstract text is available yet for this article.
May 2016: Intensive Care Medicine
https://www.readbyqxmd.com/read/26903337/epidemiology-patterns-of-care-and-mortality-for-patients-with-acute-respiratory-distress-syndrome-in-intensive-care-units-in-50-countries
#9
MULTICENTER STUDY
Giacomo Bellani, John G Laffey, Tài Pham, Eddy Fan, Laurent Brochard, Andres Esteban, Luciano Gattinoni, Frank van Haren, Anders Larsson, Daniel F McAuley, Marco Ranieri, Gordon Rubenfeld, B Taylor Thompson, Hermann Wrigge, Arthur S Slutsky, Antonio Pesenti
IMPORTANCE: Limited information exists about the epidemiology, recognition, management, and outcomes of patients with the acute respiratory distress syndrome (ARDS). OBJECTIVES: To evaluate intensive care unit (ICU) incidence and outcome of ARDS and to assess clinician recognition, ventilation management, and use of adjuncts-for example prone positioning-in routine clinical practice for patients fulfilling the ARDS Berlin Definition. DESIGN, SETTING, AND PARTICIPANTS: The Large Observational Study to Understand the Global Impact of Severe Acute Respiratory Failure (LUNG SAFE) was an international, multicenter, prospective cohort study of patients undergoing invasive or noninvasive ventilation, conducted during 4 consecutive weeks in the winter of 2014 in a convenience sample of 459 ICUs from 50 countries across 5 continents...
February 23, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/26645555/stem-cell-therapy-for-acute-respiratory-distress-syndrome-a-promising-future
#10
REVIEW
Shahd Horie, Claire Masterson, James Devaney, John G Laffey
PURPOSE OF REVIEW: Acute respiratory distress syndrome (ARDS) is a devastating disease process with a 40% mortality rate, and for which there is no therapy. Stem cells are an exciting potential therapy for ARDS, and are currently the subject of intensive ongoing research efforts. We review data concerning the therapeutic promise of cell-based therapies for ARDS. RECENT FINDINGS: Recent experimental studies suggest that cell-based therapies, particularly mesenchymal stem/stromal cells (MSCs), endothelial progenitor cells, and embryonic or induced pluripotent stem cells all offer considerable promise for ARDS...
February 2016: Current Opinion in Critical Care
https://www.readbyqxmd.com/read/26626060/what-s-new-in-cell-therapies-in-ards
#11
Shahd Horie, Gerard F Curley, John G Laffey
No abstract text is available yet for this article.
May 2016: Intensive Care Medicine
https://www.readbyqxmd.com/read/26584194/effects-and-mechanisms-by-which-hypercapnic-acidosis-inhibits-sepsis-induced-canonical-nuclear-factor-%C3%AE%C2%BAb-signaling-in-the-lung
#12
Claire Masterson, Daniel O'Toole, Annemarie Leo, Patricia McHale, Shahd Horie, James Devaney, John G Laffey
OBJECTIVE: Diverse effects of hypercapnic acidosis are mediated via inhibition of nuclear factor-κB, a pivotal transcription factor, in the setting of injury, inflammation, and repair, but the underlying mechanisms of action of hypercapnic acidosis on this pathway is unclear. We aim to examine the effect of hypercapnic acidosis on the nuclear factor-κB pathway in the setting of Escherichia coli-induced lung injury and characterize the underlying mechanisms in subsequent in vitro studies...
April 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/26472334/mesenchymal-stromal-cells-are-more-effective-than-the-msc-secretome-in-diminishing-injury-and-enhancing-recovery-following-ventilator-induced-lung-injury
#13
Mairead Hayes, Gerard F Curley, Claire Masterson, James Devaney, Daniel O'Toole, John G Laffey
BACKGROUND: The potential for mesenchymal stem cells (MSCs) to reduce the severity of experimental lung injury has been established in several pre-clinical studies. We have recently demonstrated that MSCs, and MSC-secreted factors (secretome), enhance lung repair and regeneration at 48 h following ventilation-induced lung injury (VILI). We wished to determine the potential for MSC therapy to exert beneficial effects in the early recovery phase following VILI when ongoing injury coexists with processes of repair, and to compare the efficacy of MSC therapy to the use of the secretome alone...
December 2015: Intensive Care Medicine Experimental
https://www.readbyqxmd.com/read/26271742/tracheostomy-procedures-in-the-intensive-care-unit-an-international-survey
#14
Maria Vargas, Yuda Sutherasan, Massimo Antonelli, Iole Brunetti, Antonio Corcione, John G Laffey, Christian Putensen, Giuseppe Servillo, Paolo Pelosi
INTRODUCTION: Percutaneous dilatational tracheostomy (PDT) is one of the most frequent procedures performed in the intensive care unit (ICU). PDT may add potential benefit to clinical management of critically ill patients. Despite this, no clinical guidelines are available. We sought to characterize current practice in this international survey. METHODS: An international survey, endorsed and peer reviewed by European Society of Intensive Care Medicine (ESICM), was carried out from May to October 2013...
August 13, 2015: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/26215809/angiotensin-1-7-improves-oxygenation-while-reducing-cellular-infiltrate-and-fibrosis-in-experimental-acute-respiratory-distress-syndrome
#15
Vanessa Zambelli, Giacomo Bellani, Roberto Borsa, Federico Pozzi, Alice Grassi, Margherita Scanziani, Vittoria Castiglioni, Serge Masson, Alessandra Decio, John G Laffey, Roberto Latini, Antonio Pesenti
BACKGROUND: The renin-angiotensin system (RAS) plays a role in the pathogenesis of ARDS, Angiotensin II (Ang-II) contributing to the pathogenesis of inflammation and fibrogenesis. Angiotensin-(1-7) (Ang-(1-7)) may antagonize the effects of Ang-II. This study was aimed at evaluating the potential for Ang-(1-7) to reduce injury, inflammation and fibrosis in an experimental model of ARDS in the acute and late phases. METHODS: Male Sprague Dawley rats underwent an instillation of 0...
December 2015: Intensive Care Medicine Experimental
https://www.readbyqxmd.com/read/26215802/sepsis-protects-the-myocardium-and-other-organs-from-subsequent-ischaemic-reperfusion-injury-via-a-mapk-dependent-mechanism
#16
Criona M Walshe, John G Laffey, Leo Kevin, Daniel O'Toole
BACKGROUND: Sepsis has been shown to precondition the intact heart against ischaemia/reperfusion (IR) injury, and prior endotoxin exposure of cells in in vitro models has shown evidence of protection against subsequent simulated ischaemia. Our aim in this study is to validate these findings and further investigate the signaling pathways involved. METHODS: Adult male Sprague Dawley rats were randomised to control (n = 7) or caecal ligation and perforation (CLP)-induced sepsis (n = 7)...
December 2015: Intensive Care Medicine Experimental
https://www.readbyqxmd.com/read/25986435/human-mesenchymal-stromal-cells-decrease-the-severity-of-acute-lung-injury-induced-by-e-coli-in-the-rat
#17
James Devaney, Shahd Horie, Claire Masterson, Steve Elliman, Frank Barry, Timothy O'Brien, Gerard F Curley, Daniel O'Toole, John G Laffey
BACKGROUND: Mesenchymal stromal cells (MSCs) demonstrate considerable promise in preclinical acute respiratory distress syndrome models. We wished to determine the efficacy and mechanisms of action of human MSCs (hMSCs) in the setting of acute lung injury induced by prolonged Escherichia coli pneumonia in the rat. METHODS: Adult male Sprague Dawley rats underwent intratracheal instillation of E. coli bacteria in all experiments. In Series 1, animals were randomised to intravenous administration of: (1) vehicle (phosphate buffered saline (PBS), 300 μL); (2) 1×10(7) fibroblasts/kg; (3) 1×10(7) hMSCs/kg or (4) 2×10(7) hMSCs/kg...
July 2015: Thorax
https://www.readbyqxmd.com/read/25877831/extracorporeal-membrane-oxygenation-for-blastomycosis-related-severe-ards-a-new-indication-as-a-rescue-therapy
#18
EDITORIAL
Benjamin E Steinberg, Neil M Goldenberg, John G Laffey
No abstract text is available yet for this article.
July 2015: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
https://www.readbyqxmd.com/read/25500498/permissive-hypercapnia-what-to-remember
#19
REVIEW
Maya Contreras, Claire Masterson, John G Laffey
PURPOSE OF REVIEW: Hypercapnia is a central component of diverse respiratory disorders, while 'permissive hypercapnia' is frequently used in ventilatory strategies for patients with severe respiratory failure. This review will present data from recent studies relating to hypercapnia, focusing on issues that are of importance to anesthesiologists caring for the surgical and/or critically ill patient. RECENT FINDINGS: Protective ventilatory strategies involving permissive hypercapnia are widely used in patients with severe respiratory failure, particularly in acute respiratory distress syndrome, status asthmaticus, chronic obstructive pulmonary disease and neonatal respiratory failure...
February 2015: Current Opinion in Anaesthesiology
https://www.readbyqxmd.com/read/25490744/therapeutic-efficacy-of-human-mesenchymal-stromal-cells-in-the-repair-of-established-ventilator-induced-lung-injury-in-the-rat
#20
Mairead Hayes, Claire Masterson, James Devaney, Frank Barry, Steve Elliman, Timothy O'Brien, Daniel O'Toole, Gerard F Curley, John G Laffey
BACKGROUND: Rodent mesenchymal stem/stromal cells (MSCs) enhance repair after ventilator-induced lung injury (VILI). We wished to determine the therapeutic potential of human MSCs (hMSCs) in repairing the rodent lung. METHODS: In series 1, anesthetized rats underwent VILI (series 1A, n = 8 to 9 per group) or protective ventilation (series 1B, n = 4 per group). After VILI, they were randomized to intravenous administration of (1) vehicle (phosphate-buffered saline); (2) fibroblasts (1 × 10 cells/kg); or (3) human MSCs (1 × 10 cells/kg) and the effect on restoration of lung function and structure assessed...
February 2015: Anesthesiology
keyword
keyword
84134
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"