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https://www.readbyqxmd.com/read/28823059/influence-of-dextrins-on-the-production-of-spiramycin-and-impurity-components-by-streptomyces-ambofaciens
#1
Kaiya Yao, Shuhong Gao, Yanjie Wu, Zhen Zhao, Wen Wang, Quangui Mao
Spiramycin is a 16-membered macrolide antibiotic produced by Streptomyces ambofaciens and used in human medicine for the treatment of various respiratory tract and genital infections. Several impurities were detected in spiramycin-fermentation broth, especially impurities D and F, which decreased the separation-extraction yield and increased production cost. Dextrins, as the main carbon source, influence the accumulation of spiramycin and impurities. In this work, two types of dextrin from vendor Y and Z were compared to study their influences on spiramycin production...
August 19, 2017: Folia Microbiologica
https://www.readbyqxmd.com/read/28823049/exploring-the-challenges-for-clinical-pharmacists-in-sudan
#2
Hwaida Elsadig, Marjorie Weiss, Jenny Scott, Raisa Laaksonen
Background Clinical pharmacy practice in hospitals is a new role for pharmacists in Sudan. Pharmacists have to face the challenge of moving from their traditional roles within the pharmacy premises to new roles on the wards with direct contact with patients and other healthcare professionals. Objectives To explore the role and challenges facing the clinical pharmacists of Sudan. Settings Two of the main government hospitals in Sudan and an online survey. Method This study applied a two phase mixed method, a focus group discussion and a survey...
August 19, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/28823024/effect-of-kaempferia-parviflora-extract-on-knee-osteoarthritis
#3
Hiroko Kobayashi, Ryo Suzuki, Kei Sato, Takatoshi Ogami, Hiroshi Tomozawa, Masahito Tsubata, Koji Ichinose, Masaki Aburada, Wataru Ochiai, Kiyoshi Sugiyama, Tsutomu Shimada
Knee osteoarthritis (OA) is becoming more prevalent worldwide due to increases in the numbers of elderly and obese patients. Currently, pharmaceutical medicines used for the treatment of OA are for symptomatic therapy and therefore new therapeutic agents are needed. Kaempferia parviflora (KP) is a plant growing naturally in Southeast Asia and has various pharmacological effects including an anti-inflammatory effect, but no effect on OA has yet been reported. We therefore conducted a search for the effects KP and the active components of KP extract (KPE) exert on OA as well as its mechanism of action...
August 19, 2017: Journal of Natural Medicines
https://www.readbyqxmd.com/read/28823020/perceptions-and-behaviors-of-patients-and-pharmacists-towards-generic-drug-substitution-in-lebanon
#4
Shadi Saleh, Clara Abou Samra, Stewart Jleilaty, Joanne Constantin, Nour El Arnaout, Hani Dimassi, Dania Al-Bittar
Background Patients, physicians and pharmacists are key stakeholders in the implementation of generic substitution policies. Objectives To explore Lebanese patients' perceptions and experience, and pharmacists' dispensing patterns towards the newly enacted unified health prescription policy promoting generic substitution. Setting Pharmacies in Beirut, the capital of Lebanon. Methods A cross-sectional design employing self-administered questionnaires to survey a total of 128 patients and 25 pharmacists. Chi square test and multiple logistic regression were performed...
August 19, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/28823018/prevalence-and-nature-of-potential-drug-drug-interactions-among-kidney-transplant-patients-in-a-german-intensive-care-unit
#5
Julia Amkreutz, Alexander Koch, Lukas Buendgens, Anja Muehlfeld, Christian Trautwein, Albrecht Eisert
Background Complex polypharmacotherapy makes kidney transplant patients vulnerable to drug-drug interactions (DDIs). Objective To study prevalence and nature of potential DDIs (pDDIs) in kidney transplant patients. Setting Internal medicine ICU, University Hospital RWTH Aachen. Method In this retrospective observational study, pDDIs were identified in the first week after transplant from 1999 to 2010. Patients aged at least 18 years with prescription of at least two drugs were included. Patients with incomplete data were excluded...
August 19, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/28822903/uterine-clinical-findings-fertility-rate-leucocyte-migration-and-cox-2-protein-levels-in-the-endometrial-tissue-of-susceptible-mares-treated-with-platelet-rich-plasma-before-and-after-ai
#6
Lorenzo G Segabinazzi, Aime M Friso, Sebastian B Correal, André M Crespilho, José Antonio Dell'Aqua, Jordi Miró, Frederico O Papa, Marco Antonio Alvarenga
Persistent mating-induced endometritis (PMIE) results in decreased fertility in horses, thereby causing a significant impact in the horse market. Platelet-rich plasma (PRP), a modulator of the inflammatory response, has been largely used in veterinary medicine. Here, we investigated the effects of PRP on uterine inflammation, conception rate, endometrial polymorphonuclear neutrophil (PMN) migration, and COX-2 protein levels in the endometrial tissue. Thirteen PMIE-susceptible mares were used for artificial insemination (AI)...
August 12, 2017: Theriogenology
https://www.readbyqxmd.com/read/28822788/taking-on-a-new-significance
#7
EDITORIAL
The Lancet Respiratory Medicine
No abstract text is available yet for this article.
August 16, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28822780/global-yellow-fever-vaccination-coverage-from-1970-to-2016-an-adjusted-retrospective-analysis
#8
Freya M Shearer, Catherine L Moyes, David M Pigott, Oliver J Brady, Fatima Marinho, Aniruddha Deshpande, Joshua Longbottom, Annie J Browne, Moritz U G Kraemer, Kathleen M O'Reilly, Joachim Hombach, Sergio Yactayo, Valdelaine E M de Araújo, Aglaêr A da Nóbrega, Jonathan F Mosser, Jeffrey D Stanaway, Stephen S Lim, Simon I Hay, Nick Golding, Robert C Reiner
BACKGROUND: Substantial outbreaks of yellow fever in Angola and Brazil in the past 2 years, combined with global shortages in vaccine stockpiles, highlight a pressing need to assess present control strategies. The aims of this study were to estimate global yellow fever vaccination coverage from 1970 through to 2016 at high spatial resolution and to calculate the number of individuals still requiring vaccination to reach population coverage thresholds for outbreak prevention. METHODS: For this adjusted retrospective analysis, we compiled data from a range of sources (eg, WHO reports and health-service-provider registeries) reporting on yellow fever vaccination activities between May 1, 1939, and Oct 29, 2016...
August 16, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28822767/eurostemcell-a-european-infrastructure-for-communication-and-engagement-with-stem-cell-research
#9
REVIEW
Jan Barfoot, Kate Doherty, C Clare Blackburn
EuroStemCell is a large and growing network of organizations and individuals focused on public engagement with stem cells and regenerative medicine - a fluid and contested domain, where scientific, political, ethical, legal and societal perspectives intersect. Rooted in the European stem cell research community, this project has developed collaborative and innovative approaches to information provision and direct and online engagement, that reflect and respond to the dynamic growth of the field itself. EuroStemCell started as the communication and outreach component of a research consortium and subsequently continued as a stand-alone engagement initiative...
August 16, 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/28822725/berberine-modulates-amyloid-%C3%AE-peptide-generation-by-activating-amp-activated-protein-kinase
#10
Haijing Zhang, Chunhui Zhao, Guoqiong Cao, Limin Guo, Shuai Zhang, Yuexia Liang, Chunxia Qin, Ping Su, Hang Li, Wensheng Zhang
Alzheimer's disease (AD) is an age-related neurodegenerative disorder characterized by memory deficits and cognitive decline. Excessive amyloid-β (Aβ) peptide aggregates and forms soluble oligomers and insoluble cerebral amyloid plaques, which is widely thought to be the underlying pathogenic mechanism of AD. Therefore, effective regulation of Aβ metabolism is an important aspect of preventing and improving AD. Berberine, which is the main active component of the traditional medicinal herb Coptidis rhizoma, has a positive effect on reducing Aβ levels...
August 16, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28822688/call-for-papers-in-the-area-of-cardiovascular-regenerative-medicine
#11
EDITORIAL
Seppo Ylӓ-Herttuala
No abstract text is available yet for this article.
August 16, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/28822620/medications-and-adverse-voice-effects
#12
Kátia Nemr, Ariana Di Carlos Silva, Danilo de Albuquerque Rodrigues, Marcia Simões Zenari
OBJECTIVES: To identify the medications used by patients with dysphonia, describe the voice symptoms reported on initial speech-language pathology (SLP) examination, evaluate the possible direct and indirect effects of medications on voice production, and determine the association between direct and indirect adverse voice effects and self-reported voice symptoms, hydration and smoking habits, comorbidities, vocal assessment, and type and degree of dysphonia. STUDY DESIGN: This is a retrospective cross-sectional study...
August 16, 2017: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/28822610/evaluation-of-fever-in-the-emergency-department
#13
REVIEW
Sarah DeWitt, Summer A Chavez, Jack Perkins, Brit Long, Alex Koyfman
BACKGROUND: Fever is one of the most common complaints in the emergency department (ED) and is more complex than generally appreciated. The broad differential diagnosis of fever includes numerous infectious and non-infectious etiologies. An essential skill in emergency medicine is recognizing the pitfalls in fever evaluation. OBJECTIVE OF REVIEW: This review provides an overview of the complaint of fever in the ED to assist the emergency physician with a structured approach to evaluation...
August 14, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28822596/corrigendum-to-extracellular-atp-and-adenosine-the-yin-and-yang-in-immune-responses-molecular-aspects-of-medicine-55-2017-9-19
#14
M M Faas, T Saez, P de Vos
No abstract text is available yet for this article.
August 16, 2017: Molecular Aspects of Medicine
https://www.readbyqxmd.com/read/28822578/improving-rhinology-skills-with-simulation
#15
REVIEW
Andrew Y Lee, Marvin P Fried, Marc Gibber
The convergence of technology and medicine has led to many advances in surgical training. Novel surgical simulators have led to significantly improved skills of graduating surgeons, leading to decreased time to proficiency, improved efficiency, decreased errors, and improvement in patient safety. Endoscopic sinus surgery poses a steep learning curve given the complex 3-dimensional anatomy of the nasal and paranasal cavities, and the necessary visual-spatial motor skills and bimanual dexterity. This article focuses on surgical simulation in rhinological training and how innovative high-fidelity and low-fidelity simulators can maximize resident training and improve procedural skills before operating in the live environment...
August 16, 2017: Otolaryngologic Clinics of North America
https://www.readbyqxmd.com/read/28822534/hologram-the-future-of-medicine-from-star-wars-to-clinical-imaging
#16
Sundeep Mishra
No abstract text is available yet for this article.
July 2017: Indian Heart Journal
https://www.readbyqxmd.com/read/28822450/-evaluating-the-efficacy-of-fractional-exhaled-nitric-oxide-and-impulse-oscillometry-in-screening-out-cough-variant-asthma-from-patients-with-subacute-cough
#17
S Fang, S Y Chen, X He, Q X Shen, H Z Fan, X P Wu, Z K Fang, H P Yu
Objective: To evaluate the clinical value of fractional exhaled nitric oxide (FeNO) and impulse oscillometry (IOS) in screening out cough variant asthma (CVA) from patients with subacute cough. Methods: Patients with subacute cough were included from the outpatient department of Respiratory Medicine of Zhujiang Hospital of Southern Medical University from May to October in 2016. Based on "the guidelines for the diagnosis and treatment of cough (2015 edition)" , patients were classified into CVA group, and non CVP group with other causes of subacute cough...
August 8, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28822333/virtual-screening-and-repositioning-of-inconclusive-molecules-of-beta-lactamase-bioassays-a-data-mining-approach
#18
Akshata Gad, Andrew Titus Manuel, Jinuraj K R, Lijo John, Sajeev R, Shanmuga Priya V G, Abdul Jaleel U C
This study focuses on the best possible way forward in utilizing inconclusive molecules of PubChem bioassays AID 1332, AID 434987 and AID 434955, which are related to beta-lactamase inhibitors of Mycobacterium tuberculosis (Mtb). The inadequacy in the experimental methods that were observed during the invitro screening resulted in an inconclusive dataset. This could be due to certain moieties present within the molecules. In order to reconsider such molecules, insilico methods can be suggested in place of invitro methods For instance, datamining and medicinal chemistry methods: have been adopted to prioritise the inconclusive dataset into active or inactive molecules...
July 29, 2017: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/28822292/nanoparticles-assemblies-on-demand-controlled-aggregation-of-ag-0-mediated-by-modified-peptoid-sequences
#19
Hagar Tigger-Zaborov, Galia Maayan
Assemblies of metal nanoparticles (NPs) have been broadly used for the construction of materials with distinct spectroscopic properties towards sensing applications. On the other hand, well-dispersed NPs are exploit for applications in catalysis and medicine. Biopolymers or biomimetic oligomers can serve both as efficient stabilizers of NPs and as useful aggregation mediators that can lead to assemblies with unique properties. Controlling aggregation processes, however, is still challenging and often relies on trial and error rather than on defined thumb rules...
August 12, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28822288/two-sides-of-the-coin-part-2-colloid-and-surface-science-meets-real-biointerfaces
#20
Barry W Ninham, Kåre Larsson, Pierandrea Lo Nostro
Part 1 revisited developments in lipid and surfactant self assembly over the past 40 years [1]. New concepts emerged. Here we explore how these developments can be used to make sense of and bring order to a range of complex biological phenomena. Together with Part 1, this contribution is a fundamental revision of intuition at the boundaries of Colloid Science and Biological interfaces from a perspective of nearly 50 years. We offer new insights on a unified treatment of self assembly of lipids, surfactants and proteins in the light of developments presented in Part 1...
August 5, 2017: Colloids and Surfaces. B, Biointerfaces
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