keyword
MENU ▼
Read by QxMD icon Read
search

Medicinal

keyword
https://www.readbyqxmd.com/read/29236231/dimethyl-fumarate-a-review-in-moderate-to-severe-plaque-psoriasis
#1
Hannah A Blair
Fumaric acid esters (FAEs) have been used in the treatment of psoriasis in some European countries for over 20 years, and are recommended in the European guidelines for the management of moderate to severe plaque psoriasis. Dimethyl fumarate (Skilarence®; hereafter referred to as DMF) is an orally administered FAE indicated for the treatment of moderate to severe plaque psoriasis in adults in need of systemic medicinal therapy; unlike other available FAEs, it is not formulated in combination with monoethyl fumarate salts...
December 13, 2017: Drugs
https://www.readbyqxmd.com/read/29236148/dual-antiplatelet-therapy-after-percutaneous-coronary-intervention-for-stable-cad-or-acs-redefining-the-optimal-duration-of%C3%A2-treatment
#2
B E Stähli, U Landmesser
The duration and combination of dual antiplatelet therapy after coronary stent implantation, consisting of aspirin and a P2Y12 inhibitor, is among the most intensely investigated therapeutic strategies in cardiovascular medicine. While initial studies have mainly focused on the efficacy and safety of individual antithrombotic agents, the increased need for a personalized, risk-based approach to define the optimal duration of antithrombotic treatment according to the estimated ischemic and bleeding risk was then recognized...
December 13, 2017: Herz
https://www.readbyqxmd.com/read/29236097/a-randomized-cohort-controlled-trial-to-compare-intern-sign-out-training-interventions
#3
Soo-Hoon Lee, Christopher Terndrup, Phillip H Phan, Sandra E Zaeh, Kwame Atsina, Nicole Minkove, Alexander Billioux, Souvik Chatterjee, Idoreyin Montague, Bennett Clark, Andrew Hughes, Sanjay V Desai
BACKGROUND: Although previous studies have investigated the efficacy of specific sign-out protocols (such as the illness severity, patient summary, action list, situation awareness and contingency planning, and synthesis by reviewer [I-PASS] bundle), the implementation of a bundle can be time consuming and costly. We compared 4 sign-out training pedagogies on sign-out quality. OBJECTIVE: To evaluate training interventions that best enhance multidimensional sign-out quality measured by information exchange, task accountability, and personal responsibility...
December 2017: Journal of Hospital Medicine: An Official Publication of the Society of Hospital Medicine
https://www.readbyqxmd.com/read/29236095/health-literacy-and-hospital-length-of-stay-an-inpatient-cohort-study
#4
Ethan G Jaffee, Vineet M Arora, Madeleine I Matthiesen, David O Meltzer, Valerie G Press
BACKGROUND: Associations between low health literacy (HL) and adverse health outcomes have been well documented in the outpatient setting; however, few studies have examined associations between low HL and in-hospital outcomes. OBJECTIVE: To compare hospital length of stay (LOS) among patients with low HL and those with adequate HL. DESIGN: Hospital-based cohort study. SETTING: Academic urban tertiary-care hospital. PATIENTS: Hospitalized general medicine patients...
December 2017: Journal of Hospital Medicine: An Official Publication of the Society of Hospital Medicine
https://www.readbyqxmd.com/read/29236091/noncoding-copy-number-variations-are-associated-with-congenital-limb-malformation
#5
Ricarda Flöttmann, Bjørt K Kragesteen, Sinje Geuer, Magdalena Socha, Lila Allou, Anna Sowińska-Seidler, Laure Bosquillon de Jarcy, Johannes Wagner, Aleksander Jamsheer, Barbara Oehl-Jaschkowitz, Lars Wittler, Deepthi de Silva, Ingo Kurth, Idit Maya, Fernando Santos-Simarro, Wiebke Hülsemann, Eva Klopocki, Roger Mountford, Alan Fryer, Guntram Borck, Denise Horn, Pablo Lapunzina, Meredith Wilson, Bénédicte Mascrez, Denis Duboule, Stefan Mundlos, Malte Spielmann
PurposeCopy-number variants (CNVs) are generally interpreted by linking the effects of gene dosage with phenotypes. The clinical interpretation of noncoding CNVs remains challenging. We investigated the percentage of disease-associated CNVs in patients with congenital limb malformations that affect noncoding cis-regulatory sequences versus genes sensitive to gene dosage effects.MethodsWe applied high-resolution copy-number analysis to 340 unrelated individuals with isolated limb malformation. To investigate novel candidate CNVs, we re-engineered human CNVs in mice using clustered regularly interspaced short palindromic repeats (CRISPR)-based genome editing...
October 12, 2017: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/29236081/pharmacogenomics-guided-personalization-of-warfarin-and-tamoxifen
#6
REVIEW
Theodore J Wigle, Laura E Jansen, Wendy A Teft, Richard B Kim
The use of pharmacogenomics to personalize drug therapy has been a long-sought goal for warfarin and tamoxifen. However, conflicting evidence has created reason for hesitation in recommending pharmacogenomics-guided care for both drugs. This review will provide a summary of the evidence to date on the association between cytochrome P450 enzymes and the clinical end points of warfarin and tamoxifen therapy. Further, highlighting the clinical experiences that we have gained over the past ten years of running a personalized medicine program, we will offer our perspectives on the utility and the limitations of pharmacogenomics-guided care for warfarin and tamoxifen therapy...
December 13, 2017: Journal of Personalized Medicine
https://www.readbyqxmd.com/read/29236070/lc-ms-ms-tandem-mass-spectrometry-for-analysis-of-phenolic-compounds-and-pentacyclic-triterpenes-in-antifungal-extracts-of-terminalia-brownii-fresen
#7
Enass Y A Salih, Pia Fyhrquist, Ashraf M A Abdalla, Abdelazim Y Abdelgadir, Markku Kanninen, Marketta Sipi, Olavi Luukkanen, Mustafa K M Fahmi, Mai H Elamin, Hiba A Ali
Decoctions and macerations of the stem bark and wood of Terminalia brownii Fresen. are used in traditional medicine for fungal infections and as fungicides on field crops and in traditional granaries in Sudan. In addition, T. brownii water extracts are commonly used as sprays for protecting wooden houses and furniture. Therefore, using agar disc diffusion and macrodilution methods, eight extracts of various polarities from the stem wood and bark were screened for their growth-inhibitory effects against filamentous fungi commonly causing fruit, vegetable, grain and wood decay, as well as infections in the immunocompromised host...
December 13, 2017: Antibiotics
https://www.readbyqxmd.com/read/29236057/development-of-houttuynia-cordata-extract-loaded-solid-lipid-nanoparticles-for-oral-delivery-high-drug-loading-efficiency-and-controlled-release
#8
Ju-Heon Kim, Jong-Suep Baek, Jin-Kyu Park, Bong-Joo Lee, Min-Soo Kim, Sung-Joo Hwang, Jae-Young Lee, Cheong-Weon Cho
Houttuynia cordata (H. cordata) has been used for diuresis and detoxification in folk medicine as well as a herbal medicine with antiviral and antibacterial activities. H. cordata extract-loaded solid lipid nanoparticles (H-SLNs) were prepared with various concentration of poloxamer 188 or poloxamer 407 by a hot homogenization and ultrasonication method. H-SLNs dispersion was freeze-dried with or without trehalose as a cryoprotectant. The physicochemical characteristics of H-SLNs were evaluated by dynamic laser scattering (DLS), differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FT-IR), and scanning electron microscopy (SEM)...
December 13, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29236047/hasc-and-dfat-multipotent-stem-cells-for-regenerative-medicine-a-comparison-of-their-potential-differentiation-in-vitro
#9
Marco Saler, Laura Caliogna, Laura Botta, Francesco Benazzo, Federica Riva, Giulia Gastaldi
Adipose tissue comprises both adipose and non-adipose cells such as mesenchymal stem cells. These cells show a surface antigenic profile similar to that of bone-marrow-derived MSC. The cells derived from the dedifferentiation of mature adipocytes (DFAT) are another cell population with characteristics of stemness. The aim of this study is to provide evidence of the stemness, proliferation, and differentiation of human adipose stem cells (hASC) and DFAT obtained from human subcutaneous AT and evaluate their potential use in regenerative medicine...
December 13, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29236046/advances-in-proteomic-techniques-for-cytokine-analysis-focus-on-melanoma-research
#10
REVIEW
Helena Kupcova Skalnikova, Jana Cizkova, Jakub Cervenka, Petr Vodicka
Melanoma is a skin cancer with permanently increasing incidence and resistance to therapies in advanced stages. Reports of spontaneous regression and tumour infiltration with T-lymphocytes makes melanoma candidate for immunotherapies. Cytokines are key factors regulating immune response and intercellular communication in tumour microenvironment. Cytokines may be used in therapy of melanoma to modulate immune response. Cytokines also possess diagnostic and prognostic potential and cytokine production may reflect effects of immunotherapies...
December 13, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29235944/experience-of-touch-in-health-care-a-meta-ethnography-across-the-health-care-professions
#11
Martina Ann Kelly, Lara Nixon, Caitlin McClurg, Albert Scherpbier, Nigel King, Tim Dornan
Touch mediates health professionals' interactions with patients. Different professionals have reported their practices but what is currently lacking is a well-theorized, interprofessional synthesis. We systematically searched eight databases, identified 41 studies in seven professions-nursing (27), medicine (4), physiotherapy (5), osteopathy (1), counseling (2), psychotherapy (1), dentistry (1)-and completed a meta-ethnographic line-of-argument synthesis. This found that touch is caring, exercises power, and demands safe space...
January 2018: Qualitative Health Research
https://www.readbyqxmd.com/read/29235909/the-role-of-balint-group-training-in-the-professional-and-personal-development-of-family-medicine-residents
#12
Marty Player, John R Freedy, Vanessa Diaz, Clive Brock, Alexander Chessman, Carolyn Thiedke, Alan Johnson
This paper presents a study based on the participation of PGY2 and PGY3 family medicine residents in Balint seminars that occurred twice monthly for 24 months. Balint groups were cofacilitated by leader pairs experienced with the Balint method. Prior to residency graduation, 18 of 19 eligible resident physicians (94.5%) completed 30- to 60-min semistructured interviews conducted by a research assistant. Resident physicians were told that these individual interviews concerned "…how we teach communication in residency...
January 1, 2017: International Journal of Psychiatry in Medicine
https://www.readbyqxmd.com/read/29235885/is-there-a-relation-between-the-manipulative-activity-of-toxoplasma-and-personalized-medicine
#13
Jaroslav Flegr
No abstract text is available yet for this article.
December 13, 2017: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/29235859/the-rise-and-fall-of-a-scaffold-a-trend-analysis-of-scaffolds-in-the-medicinal-chemistry-literature
#14
Barbara Zdrazil, Rajarshi Guha
Scaffolds are a core concept in medicinal chemistry and they can be the focus of multiple independent development efforts, over an extended period. Thus, scaffold associated properties can vary over time, possibly showing consistently increasing or decreasing trends. We posit that such trends characterize the attention that the community pays to a scaffold. In this study, we employed data from ChEMBL20 to examine the evolution of scaffold features, such as enumerated compounds, biological activity and liabilities, over 17 years...
December 13, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29235741/a-picture-is-worth-a-thousand-words-art-and-medicine
#15
REVIEW
Shani Dahan, Yehuda Shoenfeld
Medical practice is a form of art, with each complex detail essential to the welfare of the individuals in the care of the physician. Art and medicine have shared a close relationship in a variety of ways for centuries, as demonstrated by anatomical drawings and textbooks from the 16th century. Leonardo da Vinci, driven by his fascination with the details of the human body and how it functioned, succeeded in creating an anatomical model of the cerebral ventricles and the aorta using molten wax and a glass structure, respectively (Heart and Its Blood Vessels)...
December 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/29235704/industry-academia-partnership-the-synthesis-and-solid-state-pharmaceutical-centre-sspc-as-a-collaborative-approach-from-molecule-to-medicine
#16
Gerard P McGlacken, Sarah Hayes, Anita R Maguire, Jon O'Halloran, Kieran Hodnett
A marriage made in Ireland! The Synthesis and Solid-State Pharmaceutical Centre (SSPC) transcends company and academic boundaries and is one of the largest research collaborations of its type globally. Trust, a culture of inclusivity and commitment to mutual benefit are just some of the factors that have led to the success of the SSPC. Fostering these ideals within its industry-academia, and inter-company collaborations remains crucial to further development.
December 13, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29235676/guideline-for-diagnostic-criteria-severity-classification-and-treatment-of-eosinophilic-fasciitis
#17
Masatoshi Jinnin, Toshiyuki Yamamoto, Yoshihide Asano, Osamu Ishikawa, Shinichi Sato, Kazuhiko Takehara, Minoru Hasegawa, Manabu Fujimoto, Hironobu Ihn
We established diagnostic criteria and severity classification of eosinophilic fasciitis because there is no established diagnostic criteria or widely accepted severity classification of the disease. Also, there has been no clinical guideline for eosinophilic fasciitis, so we established its clinical guideline ahead of all over the world. In particular, the clinical guideline was established by clinical questions based on evidence-based medicine according to the New Minds Clinical Practice Guideline Creation Manual (version 1...
December 13, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/29235449/evaluation-of-skin-absorbed-doses-during-manipulation-of-radioactive-sources-a-comparison-between-varskin-code-and-monte-carlo-simulations
#18
Ernesto Amato, Antonio Italiano
The evaluation of skin doses during manipulation of radioactive sources can be a critical issue, worth using the most accurate calculation strategies available. The aim of this work was to compare the results of the analytical approach used in VARSKIN with the simulation of radiation transport and interaction by Monte Carlo calculations in GAMOS (GEANT4-based Architecture for Medicine-Oriented Simulations), and to provide an accurate and versatile tool for the evaluation of skin doses from radionuclide sources of any realistic shape (e...
December 13, 2017: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
https://www.readbyqxmd.com/read/29235444/contact-guidance-for-cardiac-tissue-engineering-using-3d-bioprinted-gelatin-patterned-hydrogel
#19
Ajay Tijore, Scott Alexander Irvine, Udi Sarig, Priyadarshini Mhaisalkar, Vrushali Baisane, Subbu S Venkatraman
Here, we have developed a 3D bioprinted microchanneled gelatin hydrogel that promotes human mesenchymal stem cell (hMSC) myocardial commitment and supports native cardiomyocytes (CMs) contractile functionality. Firstly, we studied the effect of bioprinted microchanneled hydrogel on the alignment, elongation, and differentiation of hMSC. Notably, the cells displayed well defined F-actin anisotropy and elongated morphology on the microchanneled hydrogel, hence showing the effects of topographical control over cell behavior...
December 13, 2017: Biofabrication
https://www.readbyqxmd.com/read/29235408/balint-work-and-the-creation-of-medical-knowledge
#20
John Muench
Michael Balint's pioneering work in primary care was not simply the application of psychodynamic theory to the complex problems and relationships encountered by clinicians. Rather, Balint's work was part of a wider conversation in Western epistemology that had already begun to break down the enlightenment rationalist agenda. Since the time of Descartes, we sought to find certain truth through decontextualizing and abstracting problems, and through separation of the observer from the thing observed, with a focus on finding universal timeless laws that could be generalized...
January 1, 2017: International Journal of Psychiatry in Medicine
keyword
keyword
84127
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"