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https://www.readbyqxmd.com/read/29906747/anti-tumor-and-anti-metastasis-activities-of-honey-bee-larvae-powder-by-suppressing-the-expression-of-ezh2
#1
Masakatsu Kageyama, Kejuan Li, Shuang Sun, Guoqing Xing, Ran Gao, Zhongfang Lei, Zhenya Zhang
Honey bee larvae products have been widely used as traditional daily supplements and complementary medicine for health promotion. However, there is little scientific evidence about their bioactivities. This study was designed to examine the anti-tumor and anti-metastasis effects of honey bee larvae powder (HLP) and explore the underlying mechanism. A subcutaneous transplantation model (murine breast cancer cell 4T1-LUC) and lung metastasis model (murine melanoma cell B16-F10) were established to evaluate the anti-tumor and anti-metastasis effects of HLP...
June 12, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29906743/costunolide-ameliorates-lipoteichoic-acid-induced-acute-lung-injury-via-attenuating-mapk-signaling-pathway
#2
Zhengxu Chen, Dan Zhang, Man Li, Baolong Wang
Lipoteichoic acid (LTA)-induced acute lung injury (ALI) is an experimental model for mimicking Gram-positive bacteria-induced pneumonia that is a refractory disease with lack of effective medicines. Here, we reported that costunolide, a sesquiterpene lactone, ameliorated LTA-induced ALI. Costunolide treatment reduced LTA-induced neutrophil lung infiltration, cytokine and chemokine production (TNF-α, IL-6 and KC), and pulmonary edema. In response to LTA challenge, treatment with costunolide resulted less iNOS expression and produced less inflammatory cytokines in bone marrow derived macrophages (BMDMs)...
June 12, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29906571/ebola-2018-implications-for-travel-health-advice-and-relevance-for-travel-medicine
#3
EDITORIAL
Martin P Grobusch, Frieder Schaumburg, Thomas Weitzel, Camilla Rothe, Thomas Hanscheid, Abraham Goorhuis
No abstract text is available yet for this article.
June 12, 2018: Travel Medicine and Infectious Disease
https://www.readbyqxmd.com/read/29906514/pragmatic-clinical-trials-ethical-imperatives-and-opportunities
#4
EDITORIAL
Shona Kalkman, Ghislaine J M W van Thiel, Diederick E Grobbee, Johannes J M van Delden
Pragmatic clinical trials generate robust real-world evidence that holds great potential to better inform decision making regarding new medicines. For clinicians, patients and regulators, this evidence would preferably be available sooner rather than later. This means that, ideally, market authorization of any given medicine is accompanied by evidence obtained from a pragmatic trial. Given the operational and regulatory complexities of pragmatic trials in general, stakeholders tend to be hesitant to employ more pragmatism at the time of market approval...
June 12, 2018: Drug Discovery Today
https://www.readbyqxmd.com/read/29906471/self-selection-of-plant-bioactive-compounds-by-sheep-in-response-to-challenge-infection-with-haemonchus-contortus
#5
Cesar H E C Poli, Kara J Thornton-Kurth, Jerrad F Legako, Carolina Bremm, Viviane S Hampel, Jeffery Hall, Ignacio R Ipharraguerre, Juan J Villalba
Plant bioactives can potentially benefit herbivores through their effects on health and nutrition. The objective of this study was to determine the importance of polyphenols and terpenes on the ability of lambs to self-select these compounds when challenged by a parasitic infection and the subsequent impact on their health and productivity. Thirty-five lambs were housed in individual pens and assigned to five treatment groups (7 animals/group), where they received: 1) A basal diet of beet pulp:soybean meal (90:10) (CONTROL); 2) The same diet, but containing 0...
June 12, 2018: Physiology & Behavior
https://www.readbyqxmd.com/read/29906445/common-disease-is-more-complex-than-implied-by-the-core-gene-omnigenic-model
#6
REVIEW
Naomi R Wray, Cisca Wijmenga, Patrick F Sullivan, Jian Yang, Peter M Visscher
The evidence that most adult-onset common diseases have a polygenic genetic architecture fully consistent with robust biological systems supported by multiple back-up mechanisms is now overwhelming. In this context, we consider the recent "omnigenic" or "core genes" model. A key assumption of the model is that there is a relatively small number of core genes relevant to any disease. While intuitively appealing, this model may underestimate the biological complexity of common disease, and therefore, the goal to discover core genes should not guide experimental design...
June 14, 2018: Cell
https://www.readbyqxmd.com/read/29906381/points-pearls-management-of-multiply-injured-pediatric-trauma-patients-in-the-emergency-department
#7
Andria Tatem, Rupa Kapoor, Bryan Wilson
Management of the child with multiple traumatic injuries can be challenging, and important injuries may not be readily recognized. Early recognition of serious injuries, initiation of appropriate diagnostic studies, and rapid stabilization of injuries are key to decreasing morbidity and mortality in the multiply injured pediatric trauma patient. The differential diagnosis for these patients is wide, and treatment is targeted to the specific injuries. In this issue, a systematic approach to the multiply injured pediatric patient will be reviewed, with specific attention to commonly missed injuries and those injuries that may cause significant morbidity or mortality...
June 1, 2018: Pediatric Emergency Medicine Practice
https://www.readbyqxmd.com/read/29906380/points-pearls-managing-shoulder-injuries-in-the-emergency-department-fracture-dislocation-and-overuse
#8
Richard Pescatore, Andrew Nyce, Nachi Gupta, Jeffrey Nusbaum
The complex structures of the shoulder can be injured by fracture, dislocation, and overuse, and correctly identifying and classifying injury is essential to avoiding pain, disability, and life- and limb-threatening complications. This issue presents a systematic approach to classifying shoulder injuries based on the mechanism of injury and clinical presentation, choosing appropriate imaging, and determining the best strategies for treatment, including reduction, surgical consultation, or outpatient referral...
June 1, 2018: Emergency Medicine Practice
https://www.readbyqxmd.com/read/29906342/how-to-teach-medicine-in-the-present-times-to-kids-who-are-online-all-the-time
#9
John Henderson
No abstract text is available yet for this article.
June 2018: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29906333/large-scale-geographical-mapping-of-essential-oil-volatiles-in-heracleum-apiaceae-identification-of-novel-compounds-and-unraveling-cryptic-variation
#10
Mohsen Falahati-Anbaran, Mitra Mohammadi Bazargani, Jens Rohloff
Conspecific populations of plants in their native range are expected to show considerable variation due to long-term ecological and evolutionary factors. We investigated the levels of secondary metabolites in Heracleum including H. persicum a valuable medicinal plant to depict the magnitude of cryptic variation and the potential significance of novel chemical traits. The essential oil volatiles from fruits of 34 populations from different species of Heracleum in Iranian distribution range and a native and invasive population of H...
June 15, 2018: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/29906324/electroacupuncture-treatments-for-gut-motility-disorders
#11
REVIEW
J D Z Chen, M Ni, J Yin
Functional gastrointestinal (GI) diseases are common and there are patients who are refractory to medical therapies as not all treatments work in all patients. Consequently, a large number of patients with functional GI diseases use complementary and alternative medicine, such as acupuncture or electroacupuncture (EA). In this issue, Zheng et al. reported interesting results of a multi-center placebo-controlled clinical study on the use of EA for treating refractory functional dyspepsia; another study reported a multi-center clinical trial on EA for chronic functional constipation; Liang et al...
July 2018: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/29906314/gromwell-lithospermum-erythrorhizon-root-extract-protects-against-glycation-and-related-inflammatory-and-oxidative-stress-while-offering-uv-absorption-capability
#12
Kelly M Glynn, Penny Anderson, David J Fast, James Koedam, John F Rebhun, Rodney A Velliquette
Glycation and advanced glycation endproducts (AGE) damage skin which is compounded by AGE-induced oxidative stress and inflammation. Lip and facial skin could be susceptible to glycation damage as they are chronically stressed. As Gromwell (Lithospermum erythrorhizon) root (GR) has an extensive traditional medicine history that includes providing multiple skin benefits, our objective was to determine if GR extract and its base naphthoquinone, shikonin, might protect skin by inhibiting glycation, increasing oxidative defenses, suppressing inflammatory responses, and offering ultraviolet (UV) absorptive potential in lip and facial cosmetic matrices...
June 15, 2018: Experimental Dermatology
https://www.readbyqxmd.com/read/29906268/combined-international-external-quality-assessment-results-of-medical-laboratory-performance-and-reporting-of-samples-with-known-antimicrobial-resistance
#13
Michael A Noble, Robert Rennie
BACKGROUND: Reporting on the presence of antimicrobial resistance is of considerable concern both for individual patient care and for understanding the underlying health status within the community at large. Antimicrobial resistance is solely dependent upon clinical laboratory detection and thus can be impacted upon by the quality and competence of medical laboratories. Proficiency testing or external quality assessment (PT/EQA) is the international standard for the direct measurement of medical laboratory performance on critical testing...
June 15, 2018: Diagnosis
https://www.readbyqxmd.com/read/29906001/moonlighting-in-residency-a-dermatology-perspective
#14
Jaclyn Chesner, Lauren M Ogrich, Carrie Ann Cusack, John R Durkin
BACKGROUND: Moonlighting refers to the practice of medicine outside one's training institution in exchange for financial compensation. High medical debt-to-income ratios drive residents to seek additional compensation during residency. OBJECTIVE: To gather information to establish the current practices of moonlighting and to better understand the thoughts and experiences of dermatology residency program directors regarding moonlighting. METHODS: All allopathic and osteopathic dermatology residency program directors in the United States and Puerto Rico received a blinded survey between February 1, 2017 and April 1, 2017 through an email link...
April 15, 2018: Dermatology Online Journal
https://www.readbyqxmd.com/read/29905986/bibliometric-analysis-of-100-most-cited-articles-on-oral-submucous-fibrosis
#15
Shailesh M Gondivkar, Sachin C Sarode, Amol R Gadbail, Rima S Gondivkar, Revant Chole, Gargi S Sarode
BACKGROUND: Citation analysis reflects the scientific recognition and influential performance of an article in the scientific community. The objective of this study was to identify and characterize the 100 most cited articles on oral submucous fibrosis (OSF). METHODS: A list of 100 most cited articles related to OSF was retrieved from the Science Citation Index-Expanded tool of Scopus database in May 2018.The articles were further reviewed, and basic information was recorded including the number of citations, citation density, journals, with its impact factor, category and quartile, publication year, authors, institution and country of origin, article type and level of evidence...
June 15, 2018: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/29905985/copper-mediated-trifluoromethylation-of-benzylic-csp3-h-bonds
#16
Matthew Paeth, William Carson, Jheng-Hua Luo, David L Tierney, Mu-Jeng Cheng, Zhi Cao, Wei Liu
Trifluoromethyl-containing compounds play a significant role in medicinal chemistry, materials and fine chemistry. Although direct C-H trifluoromethylation has been achieved on Csp2-H bonds, direct conversion of Csp3-H bonds to Csp3-CF3 remains challenging. We report herein an efficient protocol for the selective trifluoromethylation of benzylic C-H bonds. This process is mediated by a combination CuIII-CF3 species and persulfate salts. A wide range of methylarenes can be selectively trifluoromethylated at the benzylic positions...
June 15, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29905969/vitamin-d-supplementation-in-elderly-black-women-does-not-prevent-bone-loss-a-randomized-controlled-trial
#17
John F Aloia, Melissa Fazzari, Shahidul Islam, Mageda Mikhail, Subhashini Katumuluwa, Ruban Dhaliwal, Alexandra Stolberg, Gianina Usera, Louis Ragolia
Black Americans have lower levels of serum 25(OH)D but superior bone health compared to white Americans. There is controversy over whether they should be screened for vitamin D deficiency and have higher vitamin D requirements than recommended by the Institute of Medicine (IOM). The purpose of this trial was to determine whether Vitamin D supplementation in elderly black women prevents bone loss. 260 healthy black American women, 60 years of age and older were recruited to take part in a two arm, double-dummy 3 year RCT of vitamin D3 vs...
June 15, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29905758/short-stay-unit-hospitalisation-vs-standard-care-outcomes-in-older-internal-medicine-patients-a-randomised-clinical-trial
#18
Camilla Strøm, Lars Simon Rasmussen, Anne-Sophie Löwe, Anne Kathrine Lorentzen, Nicolai Lohse, Kim Hvid Benn Madsen, Søren Wistisen Rasmussen, Thomas Andersen Schmidt
Background: the effect of hospitalisation in emergency department-based short-stay units (SSUs) has not been studied in older patients. We compared SSU hospitalisation with standard care at an Internal Medicine Department (IMD) in acutely admitted older internal medicine patients. Methods: pragmatic randomised clinical trial. We randomly assigned patients aged 75 years or older, acutely admitted for an internal medicine disease and assessed to be suitable for SSU hospitalisation to SSU hospitalisation or IMD hospitalisation...
June 13, 2018: Age and Ageing
https://www.readbyqxmd.com/read/29905547/calcium-hydroxylapatite-microspheres-biocompatibility-and-clinical-effects
#19
U Wollina, C Wiegand, U-C Hipler
Soft tissue fillers are used in aesthetic medicine for volumizing and for contouring. Calcium hydroxylapatite (CaHA) is a fully biodegradable biostimulatory filler. The study presents results of in vitro biocompatibility and cytotoxicity investigations performed on CaHA and illustrates its clinical effects. We used a human cell culture model for in vitro studies with HaCaT keratinocytes and human dermal fibroblasts, known to be a sensitive cell type for biocompatibility and cytotoxicity. Cells were exposed to different concentrations of CaHA (Radiesse®)...
May 2018: Georgian Medical News
https://www.readbyqxmd.com/read/29905541/use-of-perfusion-mri-for-determination-of-irradiation-volumes-in-radiotherapy-of-patients-with-brain-glioma
#20
K Mardaleishvili, G Orkodashvili
Objective - to assess how rCBV maps correlate with irradiation treatment plans in patients with recurrent tumor in order to identify potential differences and optimize treatment planning. 11 patients with brain HGG have taken participation in this study. Study was conducted in Radiation Medicine Center and Scientific Research Institute of Clinical Medicine. All patients underwent DSC-MRI and routine MRI imaging prior to re-irradiation treatment planning, and underwent treatment as per routine clinical protocol...
May 2018: Georgian Medical News
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