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journal of antimicrobial chemotherapy

Emma Suggett, John Marriott
BACKGROUND: A number of methods exist for the risk assessment of hospital inpatients to determine the likelihood of patients experiencing drug-related problems (DRPs), including manual review of a patient's medication (medication reviews) and more complex electronic assessment using decision support alerts in electronic prescribing systems. A systematic review was conducted to determine the evidence base for potential risks associated with adult hospital inpatients that could not only lead to medication-related issues but might also be directly associated with pharmacist intervention...
September 2016: Drugs—Real World Outcomes
Waleed M Sweileh, Naser Y Shraim, Samah W Al-Jabi, Ansam F Sawalha, Adham S AbuTaha, Sa'ed H Zyoud
BACKGROUND: Antimicrobial resistance is a global public health challenge and carbapenem resistance, in particular, is considered an urgent global health threat. This study was carried out to give a bibliometric overview of literature on carbapenem resistance. In specific, number of publications, top productive countries and institutes, highly cited articles, citation analysis, co-authorships, international collaboration, top active authors, and journals publishing articles on carbapenem resistance were analyzed and discussed...
2016: Annals of Clinical Microbiology and Antimicrobials
Stefan Schwarz, Virve I Enne, Engeline van Duijkeren
This review, for the occasion of the 40th anniversary of the Journal of Antimicrobial Chemotherapy (JAC), gives an overview of the manuscripts related to veterinary bacteriology published in the journal in the past 40 years with a focus on 'One Health' aspects. From 1975 to 2000 the number of manuscripts related to veterinary medicine was limited, but thereafter, the number steadily increased. Most manuscripts published were related to food-producing animals, but companion animals and minor species were also covered...
October 2016: Journal of Antimicrobial Chemotherapy
Áine T De Baróid, Colin P McCoy, Rebecca A Craig, Louise Carson, Gavin P Andrews, David S Jones, Sean P Gorman
Photodynamic therapy and photodynamic antimicrobial chemotherapy are widely used, but despite this, the relationships between fluence, wavelength of irradiation and singlet oxygen ((1) O2 ) production are poorly understood. To establish the relationships between these factors in medically relevant materials, the effect of fluence on (1) O2 production from a tetrakis(4-N-methylpyridyl)porphyrin (TMPyP)-incorporated 2-hydroxyethyl methacrylate: methyl methacrylate: methacrylic acid (HEMA: MMA:MAA) copolymer, a total energy of 50...
October 27, 2015: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Bryan Ericksen
The virtual colony count (VCC) microbiological assay has been utilized for over a decade to measure the antimicrobial activity of peptides such as defensins and LL-37 against biosafety level (BSL)-1 and BSL-2 bacteria including Escherichia coli, Staphylococcus aureus, Bacillus cereus, and Enterobacter aerogenes.  In addition, a modified pipetting technique was presented in a 2011 study of defensin activity against the BSL-3 pathogen Bacillus anthracis.  Both studies were published in the journal Antimicrobial Agents and Chemotherapy...
2014: F1000Research
J Peter Donnelly
No abstract text is available yet for this article.
January 2015: Journal of Antimicrobial Chemotherapy
Matthew Dryden
This Supplement in the Journal of Antimicrobial Chemotherapy comprises a series of papers reporting on 'real-life' clinical experience with tigecycline. The data reported are derived from five European observational studies on the use of tigecycline, either as monotherapy or in combination with other antibiotics, for the treatment of complicated skin and soft-tissue infections or complicated intra-abdominal infections. Taken together, this collection of articles gives clinical insight into the use of tigecycline for the treatment of complicated infections...
July 2013: Journal of Antimicrobial Chemotherapy
Benjamin Michels
SESSION TYPE: Pleural Case Report PostersPRESENTED ON: Tuesday, October 23, 2012 at 01:30 PM - 02:30 PMINTRODUCTION: Kaposi Sarcoma(KS) and Gorham syndrome are both established but unusual causes of pleural effusion. While there is no known association, the pathogenesis of both is based on abnormal vascular proliferation. We describe a patient with both KS and Gorham syndrome who presented with recurrent pleural effusion related to pleural KS.CASE PRESENTATION: A 49 year old male presented with recurrent, symptomatic right pleural effusion...
October 1, 2012: Chest
Mona R Loutfy, Shari Margolese, Deborah M Money, Mathias Gysler, Scot Hamilton, Mark H Yudin
OBJECTIVE: Four main clinical issues need to be considered for HIV-positive individuals and couples with respect to pregnancy planning and counselling: (1) pre-conceptional health; (2) transmission from mother to infant, which has been significantly reduced by combined antiretroviral therapy; (3) transmission between partners during conception, which requires different prevention and treatment strategies depending on the status and needs of those involved; and (4) management of infertility issues...
October 2012: International Journal of Gynaecology and Obstetrics
Mona R Loutfy, Shari Margolese, Deborah M Money, Mathias Gysler, Scot Hamilton, Mark H Yudin
OBJECTIVE: Four main clinical issues need to be considered for HIV-positive individuals and couples with respect to pregnancy planning and counselling: (1) pre-conceptional health; (2) transmission from mother to infant, which has been significantly reduced by combined antiretroviral therapy; (3) transmission between partners during conception, which requires different prevention and treatment strategies depending on the status and needs of those involved; and (4) management of infertility issues...
June 2012: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
Alessandro Montedori, Maria Isabella Bonacini, Giovanni Casazza, Maria Laura Luchetta, Piergiorgio Duca, Francesco Cozzolino, Iosief Abraha
BACKGROUND: Randomized controlled trials (RCTs) that use the modified intention-to-treat (mITT) approach are increasingly being published. Such trials have a preponderance of post-randomization exclusions, industry sponsorship, and favourable findings, and little is known whether in terms of these items mITT trials are different with respect to trials that report a standard intention-to-treat. METHODS: To determine differences in the methodological quality, sponsorship, authors' conflicts of interest, and findings among trials with different "types" of intention-to-treat, we undertook a cross-sectional study of RCTs published in 2006 in three general medical journals (the Journal of the American Medical Association, the New England Journal of Medicine and the Lancet) and three specialty journals (Antimicrobial Agents and Chemotherapy, the American Heart Journal and the Journal of Clinical Oncology)...
2011: Trials
Padavala Ajay Babu, Palakeerthi Srinivas Kumar, Polumati Padmaja, T Khageswara Roa, Sashikanth Chitti
We describe a database named MIC database containing 2-dimensional structures of synthesized compounds/antibiotics, IUPAC name, smiles notation and the MIC values / zone of inhibition against a particular organism, strain and culture conditions. The data was collected from various literature sources such as Arkivoc, Bioorganic Medicinal Chemistry Letters, Antimicrobial Agents and Chemotherapy, Journal of Clinical Microbiology and Journal of Bacteriology. MIC Database can be accessed at
2009: Bioinformation
Mercedes Catalán-González, Juan Carlos Montejo-González
BACKGROUND: Invasive fungal infections are a significant cause of morbidity and mortality among immunocompromised patients. Although several new antifungal agents have been developed in the past few years, the management of serious fungal infections continues to be problematic. AIMS: To review the pharmacodynamics and pharmacokinetics of a new antifungal agent: micafungin. METHODS: A systematic review of biomedic databases (EBSCO Open Journals, Ovid Online, Proquest Medical Library, PubMed/Medline, Science Direct, Springer Links and Wiley Interscience) has been performed...
March 31, 2009: Revista Iberoamericana de Micología
Naomi Rahman, Seamus Rogers, David Ryan, Claire Healy, Stephen Flint
The latest guidelines from the American Heart Association (AHA) 2007, the Journal of the American Dental Association (JADA) 2008, the Australian Prevention of Endocarditis Guidelines 2008, the British Society for Antimicrobial Chemotherapy (BSAC) 2006, and the National Institute for Clinical Excellence (NICE) 2008 were reviewed for this article. As a result of recent literature reviews by the AHA and NICE committees, both groups made recommendations regarding antibiotic prophylaxis for dental treatment. While both agree that the benefit of prophylaxis for dental treatment is unproven, the NICE committee has recommended no antibiotic cover for any patients previously classified as 'at risk' of infective endocarditis (IE), while the AHA has recommended cover only for patients deemed to be at high risk of developing IE and with the poorest outcome in the event of IE development...
December 2008: Journal of the Irish Dental Association
Leonard Leibovici, Colin Drummond, Alan Johnson
The Journal of Antimicrobial Chemotherapy welcomes submissions of well-reported randomized controlled trials (RCTs) with solid methodology based on the CONSORT statement ( The Journal would be especially happy to publish RCTs in the area of antimicrobial chemotherapy if they address significant problems and look at measurable outcomes that matter to patients.
August 2008: Journal of Antimicrobial Chemotherapy
Leonard Leibovici, Mical Paul
Randomized controlled trials failed to show an advantage of the addition of aminoglycosides to broad-spectrum beta-lactams. In the present issue of the Journal of Antimicrobial Chemotherapy, an analysis of a large series of bacteraemic patients from Denmark, treated either with a narrow-spectrum beta-lactam or with a combination of a beta-lactam and an aminoglycoside, shows comparable outcomes in the two groups. In locations where broad-spectrum beta-lactams are in common use, the addition of an aminoglycoside does not improve efficacy and adds side effects...
November 2007: Journal of Antimicrobial Chemotherapy
Saye Khoo
Saye Khoo is Reader in the Department of Pharmacology at the University of Liverpool (UK), having graduated from the University of London in 1985. He is Honorary Consultant in Infectious Diseases, and is lead clinician for the Royal Liverpool University Hospital, and the Mersey, Cheshire & North Wales HIV Managed Care Network. Khoo has also served in the BHIVA Treatment Guidelines Writing committee, PENTA Pharmacology committee, and as an editor for the Journal of Antimicrobial Chemotherapy. Research interests include assessment of intracellular accumulation of HIV drugs, role of drug transporters, evolution of HIV resistance within drug sanctuary sites, drug-drug interactions, therapeutic drug monitoring and pharmacogenomics of HIV therapy...
January 2007: Pharmacogenomics
Peter Davey
Prudent antibiotic prescribing is a cornerstone of efforts to control the emergence and spread of antimicrobial resistance and to reduce the occurrence of Clostridium difficile associated diarrhoea, and is also currently the subject of a joint Working Party of the British Society for Antimicrobial Chemotherapy and the Hospital Infection Society. An article in this issue of the Journal describes a cluster randomized trial of an intervention to improve antibiotic prescribing using TREAT, a computerized decision support system...
December 2006: Journal of Antimicrobial Chemotherapy
Abigail Fraser, Leonard Leibovici, David S Reeves, Alan P Johnson
Good epidemiological methods and appropriate statistical analysis are cornerstones of any valid, reliable and publishable epidemiological study. This editorial summarizes epidemiological studies published in the Journal of Antimicrobial Chemotherapy (12 issues, May 2005--April 2006) with respect to study objective, type and design. A significant proportion of these studies started off with a single study group. Drawing on this finding, various methodological aspects of choosing a sampling frame and of sampling methods are reviewed...
September 2006: Journal of Antimicrobial Chemotherapy
Dilip Nathwani, et al.
This guidance document on prudent use of antibiotics and other antimicrobial drugs has been produced for NHSScotland by the Scottish Medicines Consortium (SMC). It fulfils one of the requirements set out in the Antimicrobial Resistance Strategy and Scottish Action Plan (Scottish Executive Health Department 2002) and forms part of the Healthcare Associated Infection (HAI) Action Plan work programme overseen by the Ministerial HAI Task Force. The objective was the development of a set of Good Practice Recommendations for Antimicrobial Prescribing in Hospitals to be implemented at the national or local level...
June 2006: Journal of Antimicrobial Chemotherapy
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